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Aliases for PACRGL Gene

Aliases for PACRGL Gene

  • Parkin Coregulated Like 2 3 5
  • PARK2 Coregulated Like 2 3
  • C4orf28 3 4
  • Chromosome 4 Open Reading Frame 28 2
  • PARK2 Co-Regulated Like 3
  • PACRG-Like Protein 3

External Ids for PACRGL Gene

Previous HGNC Symbols for PACRGL Gene

  • C4orf28

Previous GeneCards Identifiers for PACRGL Gene

  • GC04P020311
  • GC04P020050

Summaries for PACRGL Gene

GeneCards Summary for PACRGL Gene

PACRGL (Parkin Coregulated Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is PACRG.

Additional gene information for PACRGL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PACRGL Gene

Genomics for PACRGL Gene

GeneHancer (GH) Regulatory Elements for PACRGL Gene

Promoters and enhancers for PACRGL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I020699 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 577.9 +4.3 4264 2.2 PKNOX1 CLOCK ATF1 ARID4B SIN3A DMAP1 ZNF48 YY1 ETS1 GLIS2 PACRGL ENSG00000272995
GH04I020418 Enhancer 0.9 Ensembl ENCODE 11.2 -277.3 -277281 0.8 CTCF IRF2 RAD21 YY1 ZNF143 SMC3 SRF SMARCA5 ZNF654 CEBPB PACRGL SLIT2-IT1 GC04P020521 SLIT2
GH04I020629 Enhancer 0.6 Ensembl ENCODE 10.8 -66.7 -66716 1.1 SRF SPI1 PACRGL LOC105374515 GC04P020531
GH04I020625 Enhancer 0.6 FANTOM5 Ensembl 10.8 -70.7 -70657 0.6 SPI1 PACRGL LOC105374515 GC04P020531
GH04I020532 Enhancer 0.2 ENCODE 10.5 -163.1 -163121 2 PACRGL SLIT2 GC04P020531 LOC105374515
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PACRGL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PACRGL gene promoter:

Genomic Locations for PACRGL Gene

Genomic Locations for PACRGL Gene
chr4:20,696,282-20,766,315
(GRCh38/hg38)
Size:
70,034 bases
Orientation:
Plus strand
chr4:20,697,905-20,754,530
(GRCh37/hg19)

Genomic View for PACRGL Gene

Genes around PACRGL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PACRGL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PACRGL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PACRGL Gene

Proteins for PACRGL Gene

  • Protein details for PACRGL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7B6-PACRL_HUMAN
    Recommended name:
    PACRG-like protein
    Protein Accession:
    Q8N7B6
    Secondary Accessions:
    • B2RDB9
    • B4DFF8
    • B4DMN7
    • Q8TBA8

    Protein attributes for PACRGL Gene

    Size:
    248 amino acids
    Molecular mass:
    27152 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PACRGL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PACRGL Gene

Post-translational modifications for PACRGL Gene

No Post-translational modifications

No data available for DME Specific Peptides for PACRGL Gene

Domains & Families for PACRGL Gene

Gene Families for PACRGL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PACRGL Gene

Suggested Antigen Peptide Sequences for PACRGL Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PACRGL: view

No data available for UniProtKB/Swiss-Prot for PACRGL Gene

Function for PACRGL Gene

Gene Ontology (GO) - Molecular Function for PACRGL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PACRGL: view

Phenotypes for PACRGL Gene

GenomeRNAi human phenotypes for PACRGL:
genes like me logo Genes that share phenotypes with PACRGL: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PACRGL Gene

Localization for PACRGL Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PACRGL gene
Compartment Confidence
nucleus 3
plasma membrane 2
cytoskeleton 2
cytosol 2
extracellular 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PACRGL Gene

Pathways & Interactions for PACRGL Gene

SuperPathways for PACRGL Gene

No Data Available

Gene Ontology (GO) - Biological Process for PACRGL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PACRGL Gene

Drugs & Compounds for PACRGL Gene

No Compound Related Data Available

Transcripts for PACRGL Gene

Unigene Clusters for PACRGL Gene

PARK2 co-regulated-like:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PACRGL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for PACRGL Gene

GeneLoc Exon Structure for
PACRGL
ECgene alternative splicing isoforms for
PACRGL

Expression for PACRGL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PACRGL Gene

Protein differential expression in normal tissues from HIPED for PACRGL Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PACRGL Gene



Protein tissue co-expression partners for PACRGL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PACRGL Gene:

PACRGL

SOURCE GeneReport for Unigene cluster for PACRGL Gene:

Hs.479298

Evidence on tissue expression from TISSUES for PACRGL Gene

  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with PACRGL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PACRGL Gene

Orthologs for PACRGL Gene

This gene was present in the common ancestor of animals.

Orthologs for PACRGL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PACRGL 33 34
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia PACRGL 33 34
  • 88.44 (n)
dog
(Canis familiaris)
Mammalia PACRGL 33 34
  • 87.07 (n)
rat
(Rattus norvegicus)
Mammalia Pacrgl 33
  • 84.96 (n)
mouse
(Mus musculus)
Mammalia Pacrgl 33 16 34
  • 84.54 (n)
oppossum
(Monodelphis domestica)
Mammalia PACRGL 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PACRGL 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PACRGL 33 34
  • 74.96 (n)
lizard
(Anolis carolinensis)
Reptilia PACRGL 34
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pacrgl 33
  • 66.67 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8047 33
fruit fly
(Drosophila melanogaster)
Insecta CG17349 34
  • 19 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E04F6.2 34
  • 19 (a)
OneToOne
Species where no ortholog for PACRGL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PACRGL Gene

ENSEMBL:
Gene Tree for PACRGL (if available)
TreeFam:
Gene Tree for PACRGL (if available)

Paralogs for PACRGL Gene

Paralogs for PACRGL Gene

Pseudogenes.org Pseudogenes for PACRGL Gene

genes like me logo Genes that share paralogs with PACRGL: view

Variants for PACRGL Gene

Sequence variations from dbSNP and Humsavar for PACRGL Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000013014 -- 20,715,059(+) T/G intron_variant
rs1000030016 -- 20,738,937(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000057601 -- 20,733,288(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000076809 -- 20,723,160(+) A/C intron_variant
rs1000231471 -- 20,716,631(+) G/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PACRGL Gene

Variant ID Type Subtype PubMed ID
nsv829876 CNV gain 17160897

Variation tolerance for PACRGL Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PACRGL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PACRGL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PACRGL Gene

Disorders for PACRGL Gene

Additional Disease Information for PACRGL

No disorders were found for PACRGL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PACRGL Gene

Publications for PACRGL Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58

Products for PACRGL Gene

Sources for PACRGL Gene

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