PACRGL Gene
protein-coding GIFtS: 38
GCID: GC04P020697
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PARK2 co-regulated-like(Previous name: chromosome 4 open reading frame 28 )
(Previous symbol: C4orf28)
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Aliases
for PACRGL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| PARK2 Co-Regulated-Like1 2 | | C4orf281 2 3 | | MGC298981 | | Chromosome 4 Open Reading Frame 281 | | PACRG-Like Protein2 |
Export aliases for PACRGL gene to outside databasesPrevious GC identifers: GC04P020311 GC04P020050 |
Summaries
for PACRGL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for PACRGL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_006316.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PACRGL gene promoter:
COUP-TF1 COUP HNF-4alpha2 E4BP4 HNF-3beta Ik-3 HNF-4alpha1 Nkx6-1 COUP-TF HSF2
Other transcription factors
Search SABiosciences Chromatin IP Primers for PACRGL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PACRGL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p15.31 Ensembl cytogenetic band: 4p15.31 HGNC cytogenetic band: 4p15.31PACRGL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P020697: view genomic region
(about GC identifiers)
Start:
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20,697,905 bp from pter |
End:
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20,754,530 bp from pter |
Size:
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56,626 bases |
Orientation:
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plus strand |
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Proteins
for PACRGL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PACRL_HUMAN, Q8N7B6 (See
protein sequence)Recommended Name: PACRG-like protein Size: 248 amino acids; 27152 Da
Secondary accessions: B2RDB9 B4DFF8 B4DMN7 Q8TBA8Alternative splicing: 4 isoforms: Q8N7B6-1 Q8N7B6-2 Q8N7B6-3 Q8N7B6-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PACRGL: NX_Q8N7B6
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N7B6
PACRGL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001124199.1 NP_001245274.1 NP_001245275.1 NP_659485.1
ENSEMBL proteins: ENSP00000423914 ENSP00000423499 ENSP00000423881 ENSP00000354171 ENSP00000295290 ENSP00000426643 ENSP00000415832 ENSP00000423105 ENSP00000424391 ENSP00000421570 ENSP00000422962 ENSP00000426833 ENSP00000422394 ENSP00000425102 ENSP00000425461 ENSP00000421703 ENSP00000420948 ENSP00000422425 ENSP00000424898 ENSP00000424950 ENSP00000423536 ENSP00000427064 ENSP00000423523 ENSP00000422142 ENSP00000425938 ENSP00000422499 ENSP00000426286 ENSP00000423477 ENSP00000421687 ENSP00000426399 ENSP00000438269
Human Recombinant Protein Products:
PACRGL Antibody Products:
Assay Products for PACRGL: |
Protein
Domains /
Families
for PACRGL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PACRGL for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N7B6ProtoNet protein and cluster: Q8N7B6 |
Function
for PACRGL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PACRGL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PACRGL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): PACRGL (NM_001130727) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PACRGL | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PACRGL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACRGL |
|
Pathways & Interactions
for PACRGL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PACRGL
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for PACRGL (ENSP000002952904) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for PACRGL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PACRGL
Search CenterWatch for drugs/clinical trials and news about PACRGL / PACRL
|
Transcripts
for PACRGL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PACRGL gene (4 alternative transcripts): NM_001130727.1 NM_001258345.1 NM_001258346.1 NM_145048.3 Unigene Cluster for PACRGL: PARK2 co-regulated-like Hs.479298 [show with all ESTs]Unigene Representative Sequence: NM_00125834518/34 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 34): ENST00000471979(uc003gpu.3) ENST00000510051(uc010iei.1) ENST00000503585
ENST00000360916(uc003gpz.3 uc011bxm.2 uc003gqa.3 uc010iek.3 uc011bxn.2)
ENST00000295290 ENST00000514485 ENST00000444671 ENST00000508753 ENST00000510700
ENST00000506745 ENST00000514663 ENST00000509469 ENST00000515339 ENST00000513861
ENST00000508952 ENST00000502374 ENST00000511160 ENST00000504630
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PACRGL (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PACRGL (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): PACRGL (NM_001130727) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PACRGL | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PACRGL |
Additional cDNA sequence: AK098692.1 AK291544.1 AK294077.1 AK297556.1 AK307092.1 AK307355.1 AK307786.1 AK315482.1 BC023002.2 NR_047661.1 20 DOTS entries: DT.410002 DT.100802346 DT.97840636 DT.100802347 DT.99956683 DT.100842225 DT.99927266 DT.121236115 DT.121236138 DT.95163352 DT.40308082 DT.92427323 DT.100701196 DT.121236168 DT.95108101 DT.95179462 DT.121236120 DT.400125 DT.99958386 DT.99999992 24/103 AceView cDNA sequences (see all 103): CD742776 BQ286009 AI263607 CR621781 CR596178 CR593547 BM669830 CR625835 CD724068 AW140003 AA744135 BM669831 AW050492 CR610222 BI757170 AA709033 BG741791 BF111800 BX117992 BF111663 BI757123 AL040761 BI753408 AA905347
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for PACRGL About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 |
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| SP1: | | | - | | | | | | | | | | | | - | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | | | | |
ECgene alternative splicing isoforms for PACRGL
|
Expression
for PACRGL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PACRGL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See PACRGL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PACRGL
SOURCE GeneReport for Unigene cluster: Hs.479298
SABiosciences Custom PCR Arrays for PACRGL
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PACRGL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PACRGL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PACRGL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACRGL |
Orthologs
for PACRGL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PACRGL gene from 6/16 species (see all 16) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Pacrgl1 , 5 |
PARK2 co-regulated-like1, 5 |
84.77(n)1
87.78(a)1 |
|
5 (26.25 cM)5
667681 NM_025755.31 NP_080031.11
483723925 |
chicken
(Gallus gallus) |
Aves |
PACRGL1 |
PARK2 co-regulated-like |
74.96(n)
76.14(a) |
|
422818 XM_420764.3 XP_420764.1 |
lizard
(Anolis carolinensis) |
Reptilia |
PACRGL6 |
-- |
66(a) |
1 ↔ 1 |
5(75588187-75599956) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.80472 |
Xenopus laevis transcribed sequence with weak similarity to protein refNP_495496.1 (C.elegans) E04F6.2.p [Caenorhabditis elegans] less |
79.46(n) |
|
BX849436.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG173496 |
-- |
16(a) |
1 ↔ 1 |
2L(19370478-19372711) |
worm
(Caenorhabditis elegans) |
Secernentea |
E04F6.26 |
Protein E04F6.2 |
17(a) |
1 ↔ 1 |
II(7200570-7201839) |
ENSEMBL Gene Tree for PACRGL (if available)
TreeFam Gene Tree for PACRGL (if available) |
Paralogs
for PACRGL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PACRGL gene
- PACRG2
PACRGL for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for PACRGL
PGOHUM00000251092
|
Genomic Variants
for PACRGL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PACRGL |
|
Disorders
/ Diseases
for PACRGL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for PACRGL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PACRGL gene integrated from 9 sources:
(articles sorted by number of sources associating them with PACRGL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for PACRGL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing PACRGL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PACRGL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PACRGL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PACRGL | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PACRGL gene:
Search GeneIP for patents involving PACRGL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PACRGL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 |
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PACRGL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PACRGL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PACRGL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PACRGL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PACRGL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PACRGL |
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 | | | PACRGL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACRGL |
|  |  |  | | | | Search ThermoFisher Antibodies for PACRGL |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PACRGL |
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