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Aliases for PACRGL Gene

Aliases for PACRGL Gene

  • PARK2 Co-Regulated Like 2 3 5
  • PARK2 Co-Regulated-Like 2 3
  • C4orf28 3 4
  • Chromosome 4 Open Reading Frame 28 2

External Ids for PACRGL Gene

Previous HGNC Symbols for PACRGL Gene

  • C4orf28

Previous GeneCards Identifiers for PACRGL Gene

  • GC04P020311
  • GC04P020050

Summaries for PACRGL Gene

GeneCards Summary for PACRGL Gene

PACRGL (PARK2 Co-Regulated Like) is a Protein Coding gene. GO annotations related to this gene include binding. An important paralog of this gene is PACRG.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PACRGL Gene

Genomics for PACRGL Gene

Regulatory Elements for PACRGL Gene

Genomic Location for PACRGL Gene

Chromosome:
4
Start:
20,696,282 bp from pter
End:
20,766,315 bp from pter
Size:
70,034 bases
Orientation:
Plus strand

Genomic View for PACRGL Gene

Genes around PACRGL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PACRGL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PACRGL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PACRGL Gene

Proteins for PACRGL Gene

  • Protein details for PACRGL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7B6-PACRL_HUMAN
    Recommended name:
    PACRG-like protein
    Protein Accession:
    Q8N7B6
    Secondary Accessions:
    • B2RDB9
    • B4DFF8
    • B4DMN7
    • Q8TBA8

    Protein attributes for PACRGL Gene

    Size:
    248 amino acids
    Molecular mass:
    27152 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PACRGL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PACRGL Gene

Proteomics data for PACRGL Gene at MOPED

Post-translational modifications for PACRGL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PACRGL Gene

Domains & Families for PACRGL Gene

Protein Domains for PACRGL Gene

Suggested Antigen Peptide Sequences for PACRGL Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PACRGL: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PACRGL Gene

Function for PACRGL Gene

Phenotypes for PACRGL Gene

GenomeRNAi human phenotypes for PACRGL:
genes like me logo Genes that share phenotypes with PACRGL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PACRGL Gene

Localization for PACRGL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PACRGL Gene COMPARTMENTS Subcellular localization image for PACRGL gene
Compartment Confidence
nucleus 3
cytoskeleton 2
cytosol 2
plasma membrane 2
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PACRGL Gene

Pathways & Interactions for PACRGL Gene

SuperPathways for PACRGL Gene

No Data Available

Gene Ontology (GO) - Biological Process for PACRGL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PACRGL Gene

Drugs & Compounds for PACRGL Gene

No Compound Related Data Available

Transcripts for PACRGL Gene

Unigene Clusters for PACRGL Gene

PARK2 co-regulated-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PACRGL Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for PACRGL Gene

GeneLoc Exon Structure for
PACRGL
ECgene alternative splicing isoforms for
PACRGL

Expression for PACRGL Gene

mRNA expression in normal human tissues for PACRGL Gene

Protein differential expression in normal tissues from HIPED for PACRGL Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PACRGL Gene



SOURCE GeneReport for Unigene cluster for PACRGL Gene Hs.479298

genes like me logo Genes that share expression patterns with PACRGL: view

Protein tissue co-expression partners for PACRGL Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PACRGL Gene

Orthologs for PACRGL Gene

This gene was present in the common ancestor of animals.

Orthologs for PACRGL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PACRGL 35
  • 88.44 (n)
  • 89.11 (a)
PACRGL 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PACRGL 35
  • 87.07 (n)
  • 88.57 (a)
PACRGL 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pacrgl 35
  • 84.54 (n)
  • 88.71 (a)
Pacrgl 16
Pacrgl 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PACRGL 35
  • 99.6 (n)
  • 98.79 (a)
PACRGL 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pacrgl 35
  • 84.96 (n)
  • 89.02 (a)
oppossum
(Monodelphis domestica)
Mammalia PACRGL 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PACRGL 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves PACRGL 35
  • 74.96 (n)
  • 74.24 (a)
PACRGL 36
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PACRGL 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pacrgl 35
  • 66.67 (n)
  • 68 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8047 35
fruit fly
(Drosophila melanogaster)
Insecta CG17349 36
  • 19 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E04F6.2 36
  • 19 (a)
OneToOne
Species with no ortholog for PACRGL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PACRGL Gene

ENSEMBL:
Gene Tree for PACRGL (if available)
TreeFam:
Gene Tree for PACRGL (if available)

Paralogs for PACRGL Gene

Paralogs for PACRGL Gene

Pseudogenes.org Pseudogenes for PACRGL Gene

genes like me logo Genes that share paralogs with PACRGL: view

Variants for PACRGL Gene

Sequence variations from dbSNP and Humsavar for PACRGL Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs919141 -- 20,699,647(+) GTTAC(C/T)TAAGC intron-variant, upstream-variant-2KB
rs964019 -- 20,702,433(+) GTGGT(C/T)TCACT intron-variant, upstream-variant-2KB
rs964020 -- 20,702,460(+) CTGAA(A/G)AACAC intron-variant, upstream-variant-2KB
rs974726 -- 20,700,883(+) CTGGC(C/T)CTGGA intron-variant, upstream-variant-2KB
rs1061836 -- 20,728,066(+) ACAGG(C/T)GTGAG intron-variant, nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PACRGL Gene

Variant ID Type Subtype PubMed ID
nsv829876 CNV Gain 17160897

Variation tolerance for PACRGL Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PACRGL Gene

HapMap Linkage Disequilibrium report
PACRGL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PACRGL Gene

Disorders for PACRGL Gene

Relevant External Links for PACRGL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PACRGL

No disorders were found for PACRGL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PACRGL Gene

Publications for PACRGL Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for PACRGL Gene

Sources for PACRGL Gene

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