Aliases for PACRG Gene
External Ids for PACRG Gene
Previous GeneCards Identifiers for PACRG Gene
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for PACRG Gene
PACRG (PARK2 Co-Regulated) is a Protein Coding gene. Diseases associated with PACRG include Leprosy and Parkinson Disease, Juvenile, Type 2. GO annotations related to this gene include binding and ubiquitin protein ligase binding. An important paralog of this gene is PACRGL.
UniProtKB/Swiss-Prot for PACRG Gene
Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.