PACRG Gene
protein-coding GIFtS: 51
GCID: GC06P163118
|
|
PARK2 co-regulated
| |
Aliases
for PACRG gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| PARK2 Co-Regulated1 2 | | Glup1 | | HAK0057711 2 | | RP3-495O10.22 | | PARK2CRG1 2 | | Parkin Co-Regulated Gene Protein2 | | Molecular Chaperone/Chaperonin-Binding Protein2 3 | | Parkin Coregulated Gene Protein2 | | GLUP2 3 | | PARK2 Coregulated Gene Protein3 | | FLJ327241 | | |
Export aliases for PACRG gene to outside databasesPrevious GC identifers: GC06P162502 GC06P163021 GC06P163057 GC06P160600 |
Summaries
for PACRG gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PACRG:
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-headarrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease.These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associatedwith susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones,including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies inParkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multipletranscript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: PACRG_HUMAN, Q96M98Function: Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin).Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules anditself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection ofdopaminergic neurons against Parkinson disease
Gene Wiki entry for PACRG
|
Genomic Views
for PACRG gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_025741.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PACRG gene promoter:
GR GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for PACRG
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PACRG |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q26 Ensembl cytogenetic band: 6q26 HGNC cytogenetic band: 6q26PACRG Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P163118: view genomic region
(about GC identifiers)
Start:
|
163,148,164 bp from pter |
End:
|
163,736,524 bp from pter |
Size:
|
588,361 bases |
Orientation:
|
plus strand |
|
Proteins
for PACRG gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PACRG_HUMAN, Q96M98 (See
protein sequence)Recommended Name: Parkin coregulated gene protein Size: 296 amino acids; 33342 Da
Subunit: Forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components.Interacts with STIP1, PARK2, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8. Interacts with MEIG1(By similarity)
Miscellaneous: Linked to PARK2 in a head-to-head arrangement on opposite DNA strands and share a common 5'-flankingpromoter region
Secondary accessions: E1P5B5 Q6IMB8 Q8IZM1 Q8NHP5 Q9H1V9Alternative splicing: 2 isoforms: Q96M98-1 Q96M98-2 (May be due to exon skipping)Explore the universe of human proteins at neXtProt for PACRG: NX_Q96M98
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96M98
PACRG Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001073847.1 NP_001073848.1 NP_689623.2
ENSEMBL proteins: ENSP00000337946 ENSP00000355855 ENSP00000355854 ENSP00000440706 ENSP00000442879 ENSP00000438242
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
PACRG for ontologies About GeneDecksing
PACRG Antibody Products:
Assay Products for PACRG: |
Protein
Domains /
Families
for PACRG gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PACRG for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96M98ProtoNet protein and cluster: Q96M98 |
Function
for PACRG gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PACRG_HUMAN, Q96M98Function: Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin).Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules anditself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection ofdopaminergic neurons against Parkinson disease
Clone
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACRG |
|
Pathways & Interactions
for PACRG gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PACRG
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for PACRG (ENSP000003379464) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007286 | spermatid development |
IEA | -- |
PACRG for ontologies About GeneDecksing
|
Drugs & Compounds
for PACRG gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PACRG
Search CenterWatch for drugs/clinical trials and news about PACRG
|
Transcripts
for PACRG gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PACRG gene (3 alternative transcripts): NM_001080378.1 NM_001080379.1 NM_152410.2 Unigene Cluster for PACRG: PARK2 co-regulated Hs.25791 [show with all ESTs]Unigene Representative Sequence: NM_1524109 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000337019(uc003qua.3) ENST00000366889(uc003qub.3) ENST00000366888(uc003quc.3)
ENST00000542669 ENST00000544266 ENST00000541974 ENST00000534958 ENST00000545186
ENST00000542936
Clone
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OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Additional cDNA sequence: AF546872.1 AK057286.1 BC030642.2 BC044227.1 6 DOTS entries: DT.97840033 DT.100749673 DT.99943065 DT.86846739 DT.95266722 DT.91898239 24/64 AceView cDNA sequences (see all 64): AW205586 BU624957 AA398695 BK001670 BM980788 AF546872 AA776722 BC044227 BM708518 BE501088 BX282726 AI188068 BG221533 BC030642 AA916760 NM_152410 AI347899 BM552762 AI830880 BE672396 AA393483 AA932585 BI599952 BI912716
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for PACRG About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for PACRG
|
Expression
for PACRG gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PACRG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTGGAACACG
About this image
See PACRG Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PACRG
SOURCE GeneReport for Unigene cluster: Hs.25791
UniProtKB/Swiss-Prot: PACRG_HUMAN, Q96M98Tissue specificity: Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow.Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells andvery weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent ofleprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients
SABiosciences Custom PCR Arrays for PACRG
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PACRG
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PACRG |
Orthologs
for PACRG gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for PACRG gene from 5/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PACRG1 |
PARK2 co-regulated |
81.9(n)
88.36(a) |
|
421576 XM_419614.3 XP_419614.2 |
lizard
(Anolis carolinensis) |
Reptilia |
PACRG6 |
-- |
89(a) |
1 ↔ 1 |
1(210426699-210435741) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.164552 |
Transcribed sequence with weak similarity to protein more |
81.24(n) |
|
BX699883.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.90812 |
Transcribed sequence with weak similarity to protein more |
79.75(n) |
|
57071368 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG151201 |
CG15120 |
61.63(n)
59.9(a) |
|
37248 NM_137584.2 NP_611428.1 |
ENSEMBL Gene Tree for PACRG (if available)
TreeFam Gene Tree for PACRG (if available) |
Paralogs
for PACRG gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PACRG gene
- PACRGL2
7 SIMAP similar genes for PACRG using alignment to 5 protein entries: PACRG_HUMAN (see all proteins):PFKFB3 TUBA1C NCKAP1L AURA2 COQ5 C21orf37
C12orf76
PACRG for paralogs About GeneDecksing
|
Genomic Variants
for PACRG gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
UniProtKB/Swiss-Prot: PACRG_HUMAN, Q96M98Polymorphism: Involved in susceptibility to leprosy (LPRS2) [MIM:607572]. LPRS2 is associated with polymorphisms in the5'-regulatory region shared by the PARK2 gene
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PACRG (163148164 - 163398164 bp, first 250kb of PACRG)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PACRG
2 CNVs: 2665 4515
Human Gene Mutation Database (HGMD): PACRG
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PACRG |
|
Disorders
/ Diseases
for PACRG gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PACRG for disorders About GeneDecksing
OMIM gene information: 608427
OMIM disorders: --
17  diseases for PACRG: About MalaCardsparkinson's disease autosomal recessive juvenile parkinson disease leprosy paratyphoid fever
male infertility acute lymphoblastic leukemia chronic myeloid leukemia lymphoblastic leukemia
neuronitis myeloid leukemia hydrocephalus pulmonary tuberculosis
infertility tonsillitis leukemia tuberculosis
hypertension
2 diseases from the University of Copenhagen DISEASES database for PACRG:Leprosy Parkinson's disease 2 Novoseek disease relationships for PACRG gene About this table
Genetic Association Database (GAD): PACRG
Human Genome Epidemiology (HuGE) Navigator: PACRG (8 documents)
Export disorders for PACRG gene to outside databases
|
Publications
for PACRG gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PACRG gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with PACRG) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a novel gene linked to parkin via a bi-directional promoter. (PubMed id 12547187)1, 2, 3, 9 West A.B.... Farrer M.J. (2003)
- Susceptibility to leprosy is associated with PARK2 and PACRG. (PubMed id 14737177)1, 2, 4 Mira M.T.... Schurr E. (2004)
- Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonism. (PubMed id 15925106)1, 4, 9 Deng H....Jankovic J. (2005)
- Association study of major risk single nucleotide polymorphisms in the common regulatory region of PARK2 and PACRG genes with leprosy in an Indian population. (PubMed id 16391553)1, 4 Malhotra D....Bamezai R.N. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death. (PubMed id 14532270)1, 2 Imai Y.... Takahashi R. (2003)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia. (PubMed id 16287063)1, 9 Agirre X....Prosper F. (2006)
- Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases. (PubMed id 17590346)1, 9 Taylor J.M....Lockhart P.J. (2007)
|
External Searches for PACRG gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PACRG gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PACRG gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PACRG gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PACRG | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PACRG gene:
Search GeneIP for patents involving PACRG
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PACRG gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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