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Aliases for PACRG Gene

Aliases for PACRG Gene

  • PARK2 Coregulated 2 3 5
  • Molecular Chaperone/Chaperonin-Binding Protein 3 4
  • GLUP 3 4
  • Parkin Co-Regulated Gene Protein 3
  • Parkin Coregulated Gene Protein 3
  • PARK2 Coregulated Gene Protein 4
  • PARK2 Co-Regulated 3
  • HAK005771 3
  • PARK2CRG 3

External Ids for PACRG Gene

Previous GeneCards Identifiers for PACRG Gene

  • GC06P162502
  • GC06P163021
  • GC06P163057
  • GC06P163118
  • GC06P160600

Summaries for PACRG Gene

Entrez Gene Summary for PACRG Gene

  • This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PACRG Gene

PACRG (PARK2 Coregulated) is a Protein Coding gene. Diseases associated with PACRG include Leprosy and Parkinson Disease, Juvenile, Type 2. GO annotations related to this gene include binding and ubiquitin protein ligase binding. An important paralog of this gene is PACRGL.

UniProtKB/Swiss-Prot for PACRG Gene

  • Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.

Gene Wiki entry for PACRG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PACRG Gene

Genomics for PACRG Gene

Regulatory Elements for PACRG Gene

Enhancers for PACRG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around PACRG on UCSC Golden Path with GeneCards custom track

Promoters for PACRG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PACRG on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the PACRG gene promoter:

Genomic Location for PACRG Gene

Chromosome:
6
Start:
162,727,084 bp from pter
End:
163,315,492 bp from pter
Size:
588,409 bases
Orientation:
Plus strand

Genomic View for PACRG Gene

Genes around PACRG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PACRG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PACRG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PACRG Gene

Proteins for PACRG Gene

  • Protein details for PACRG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96M98-PACRG_HUMAN
    Recommended name:
    Parkin coregulated gene protein
    Protein Accession:
    Q96M98
    Secondary Accessions:
    • E1P5B5
    • Q6IMB8
    • Q8IZM1
    • Q8NHP5
    • Q9H1V9

    Protein attributes for PACRG Gene

    Size:
    296 amino acids
    Molecular mass:
    33342 Da
    Quaternary structure:
    • Forms a large molecular chaperone complex containing heat shock proteins 70 and 90 and chaperonin components. Interacts with STIP1, PARK2, GPR37, HSPA8, TCP1/CCT1, CCT2, CCT3, CCT4, CCT5, CCT6A, CCT7, CCT8. Interacts with MEIG1 (By similarity).
    Miscellaneous:
    • Linked to PARK2 in a head-to-head arrangement on opposite DNA strands and share a common 5-flanking promoter region.

    Alternative splice isoforms for PACRG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PACRG Gene

Post-translational modifications for PACRG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PACRG Gene

Domains & Families for PACRG Gene

Protein Domains for PACRG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PACRG Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PACRG: view

No data available for Gene Families and UniProtKB/Swiss-Prot for PACRG Gene

Function for PACRG Gene

Molecular function for PACRG Gene

UniProtKB/Swiss-Prot Function:
Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited. May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease.

Gene Ontology (GO) - Molecular Function for PACRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IPI 14532270
GO:0003779 actin binding IDA 14532270
GO:0030544 Hsp70 protein binding IDA 14532270
GO:0031072 heat shock protein binding IPI 14532270
GO:0031625 ubiquitin protein ligase binding IPI 14532270
genes like me logo Genes that share ontologies with PACRG: view
genes like me logo Genes that share phenotypes with PACRG: view

Human Phenotype Ontology for PACRG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for PACRG Gene

miRTarBase miRNAs that target PACRG

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PACRG Gene

Localization for PACRG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PACRG Gene COMPARTMENTS Subcellular localization image for PACRG gene
Compartment Confidence
cytosol 5
nucleus 5
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PACRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005739 mitochondrion IEA --
GO:0005829 cytosol IDA 14532270
GO:0005929 cilium IEA --
GO:0031982 vesicle IDA 14532270
genes like me logo Genes that share ontologies with PACRG: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PACRG Gene

Pathways & Interactions for PACRG Gene

SuperPathways for PACRG Gene

No Data Available

Gene Ontology (GO) - Biological Process for PACRG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007286 spermatid development IEA --
GO:0034620 cellular response to unfolded protein TAS 14532270
GO:0060548 negative regulation of cell death IMP 14532270
genes like me logo Genes that share ontologies with PACRG: view

No data available for Pathways by source and SIGNOR curated interactions for PACRG Gene

Drugs & Compounds for PACRG Gene

No Compound Related Data Available

Transcripts for PACRG Gene

Unigene Clusters for PACRG Gene

PARK2 co-regulated:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PACRG Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2: - -
SP3: -

Relevant External Links for PACRG Gene

GeneLoc Exon Structure for
PACRG
ECgene alternative splicing isoforms for
PACRG

Expression for PACRG Gene

mRNA expression in normal human tissues for PACRG Gene

mRNA differential expression in normal tissues according to GTEx for PACRG Gene

This gene is overexpressed in Testis (x6.3) and Pituitary (x5.6).

Protein differential expression in normal tissues from HIPED for PACRG Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PACRG Gene



Protein tissue co-expression partners for PACRG Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PACRG Gene:

PACRG

SOURCE GeneReport for Unigene cluster for PACRG Gene:

Hs.25791

mRNA Expression by UniProt/SwissProt for PACRG Gene:

Q96M98-PACRG_HUMAN
Tissue specificity: Expressed in all immune tissues, spleen, lymph nodes, thymus, tonsils, leukocyte and bone marrow. Expressed also in heart, brain, skeletal muscle, kidney, lung and pancreas. Expressed in primary Schwann cells and very weakly by monocyte-derived macrophages the primary host cells of Mycobacterium leprae, the causative agent of leprosy. Component of Lewy bodies, intraneuronal inclusions found in the brain of Parkinson disease patients.
genes like me logo Genes that share expression patterns with PACRG: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PACRG Gene

Orthologs for PACRG Gene

This gene was present in the common ancestor of animals.

Orthologs for PACRG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PACRG 34
  • 86.03 (n)
  • 90.44 (a)
PACRG 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PACRG 34
  • 93.77 (n)
  • 97.67 (a)
PACRG 35
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pacrg 34
  • 88.8 (n)
  • 92.12 (a)
Pacrg 16
Pacrg 35
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PACRG 34
  • 99.44 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia LOC100912128 34
  • 90.66 (n)
  • 96.11 (a)
oppossum
(Monodelphis domestica)
Mammalia PACRG 35
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PACRG 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves PACRG 34
  • 81.9 (n)
  • 88.36 (a)
PACRG 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PACRG 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100127543 34
  • 80.82 (n)
  • 91.32 (a)
Str.16455 34
zebrafish
(Danio rerio)
Actinopterygii Dr.9081 34
pacrg 34
  • 76.13 (n)
  • 89.19 (a)
pacrg 35
  • 84 (a)
OneToMany
PACRG (2 of 2) 35
  • 91 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1100 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011313 34
  • 62.79 (n)
  • 61.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15120 34
  • 61.63 (n)
  • 59.9 (a)
CG15120 35
  • 40 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10208 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4180 35
  • 76 (a)
OneToOne
Species where no ortholog for PACRG was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PACRG Gene

ENSEMBL:
Gene Tree for PACRG (if available)
TreeFam:
Gene Tree for PACRG (if available)

Paralogs for PACRG Gene

Paralogs for PACRG Gene

(7) SIMAP similar genes for PACRG Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PACRG: view

Variants for PACRG Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for PACRG Gene

PACRG_HUMAN-Q96M98
Involved in susceptibility to leprosy (LPRS2) [MIM:607572]. LPRS2 is associated with polymorphisms in the 5-regulatory region shared by the PARK2 gene.

Sequence variations from dbSNP and Humsavar for PACRG Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs867054 -- 162,829,736(-) TCCTA(C/G/T)ACCCG intron-variant
rs868708 -- 162,838,228(-) gatgg(C/T)cttac intron-variant
rs874292 -- 163,178,028(-) CACTC(A/C)TTGTT intron-variant
rs908018 -- 162,898,076(+) GAAAG(A/G)GAGTG intron-variant
rs915013 -- 162,903,810(-) CTCAC(A/G)ATCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PACRG Gene

Variant ID Type Subtype PubMed ID
dgv11022n54 CNV loss 21841781
dgv3432n106 CNV tandem duplication 24896259
dgv3433n106 CNV deletion 24896259
dgv6176n100 CNV gain 25217958
esv1009462 CNV insertion 20482838
esv1529490 CNV insertion 17803354
esv1778979 CNV insertion 17803354
esv2657084 CNV deletion 23128226
esv2666520 CNV deletion 23128226
esv2733107 CNV deletion 23290073
esv2733108 CNV deletion 23290073
esv2733109 CNV deletion 23290073
esv2733110 CNV deletion 23290073
esv2733111 CNV deletion 23290073
esv275472 CNV loss 21479260
esv2759489 CNV gain 17122850
esv2762627 CNV loss 21179565
esv2762628 CNV gain 21179565
esv3303354 CNV mobile element insertion 20981092
esv3305998 CNV mobile element insertion 20981092
esv3348036 CNV insertion 20981092
esv3356099 CNV insertion 20981092
esv3378117 CNV duplication 20981092
esv3418427 CNV insertion 20981092
esv3437189 CNV insertion 20981092
esv3448928 CNV insertion 20981092
esv3540819 CNV deletion 23714750
esv3571505 CNV loss 25503493
esv3611566 CNV loss 21293372
esv3611567 CNV loss 21293372
esv3611568 CNV loss 21293372
esv3611569 CNV loss 21293372
esv3611570 CNV loss 21293372
esv3611571 CNV loss 21293372
esv3611572 CNV loss 21293372
esv3611574 CNV loss 21293372
esv3611575 CNV loss 21293372
esv3890992 CNV loss 25118596
nsv1015507 CNV gain 25217958
nsv1018573 CNV loss 25217958
nsv1021433 CNV loss 25217958
nsv1024624 CNV loss 25217958
nsv1025098 CNV loss 25217958
nsv1026490 CNV gain 25217958
nsv1030116 CNV gain 25217958
nsv1137174 CNV deletion 24896259
nsv1139877 CNV duplication 24896259
nsv1145801 CNV insertion 26484159
nsv1146089 CNV duplication 26484159
nsv349311 CNV insertion 16902084
nsv349630 CNV insertion 16902084
nsv464126 CNV loss 19166990
nsv477392 CNV novel sequence insertion 20440878
nsv509165 CNV insertion 20534489
nsv517562 CNV gain+loss 19592680
nsv520096 CNV loss 19592680
nsv521563 CNV gain 19592680
nsv522316 CNV loss 19592680
nsv605159 CNV loss 21841781
nsv605180 CNV loss 21841781
nsv605181 CNV gain 21841781
nsv605182 CNV gain 21841781
nsv605185 CNV gain 21841781
nsv605186 CNV loss 21841781
nsv605187 CNV loss 21841781
nsv605188 CNV loss 21841781
nsv830857 CNV loss 17160897
nsv970191 CNV duplication 23825009

Variation tolerance for PACRG Gene

Residual Variation Intolerance Score: 42.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PACRG Gene

Human Gene Mutation Database (HGMD)
PACRG
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PACRG

Disorders for PACRG Gene

MalaCards: The human disease database

(3) MalaCards diseases for PACRG Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
leprosy
  • leprosy 2
parkinson disease, juvenile, type 2
  • autosomal recessive juvenile parkinson disease 2
parkinson disease, late-onset
  • parkinson disease
- elite association - COSMIC cancer census association via MalaCards
Search PACRG in MalaCards View complete list of genes associated with diseases

Relevant External Links for PACRG

Genetic Association Database (GAD)
PACRG
Human Genome Epidemiology (HuGE) Navigator
PACRG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PACRG
genes like me logo Genes that share disorders with PACRG: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PACRG Gene

Publications for PACRG Gene

  1. Identification of a novel gene linked to parkin via a bi-directional promoter. (PMID: 12547187) West A.B. … Farrer M.J. (J. Mol. Biol. 2003) 2 3 4 22 65
  2. Molecular analysis of the PArkin co-regulated gene and association with male infertility. (PMID: 19268936) Wilson G.R. … Lockhart P.J. (Fertil. Steril. 2010) 3 22 46 65
  3. Analysis of PArkin Co-Regulated Gene in a Taiwanese-ethnic Chinese cohort with early-onset Parkinson's disease. (PMID: 19196541) Taylor J.M. … Lockhart P.J. (Parkinsonism Relat. Disord. 2009) 3 22 46 65
  4. Genetic analysis of parkin co-regulated gene (PACRG) in patients with early-onset parkinsonism. (PMID: 15925106) Deng H. … Jankovic J. (Neurosci. Lett. 2005) 3 22 46 65
  5. Susceptibility to leprosy is associated with PARK2 and PACRG. (PMID: 14737177) Mira M.T. … Schurr E. (Nature 2004) 3 4 46 65

Products for PACRG Gene

Sources for PACRG Gene

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