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Aliases for PACERR Gene

Subcategory (RNA class) for PACERR Gene

non-coding RNA

Quality Score for this RNA gene is

3

Aliases for PACERR Gene

  • PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA 2 3 5
  • PTGS2 Antisense RNA 1 (Head To Head) 2 3
  • P50-Associated COX-2 Extragenic RNA 2 3
  • PTGS2-AS1 3
  • PTGS2AS1 3
  • PACER 3

External Ids for PACERR Gene

Summaries for PACERR Gene

Entrez Gene Summary for PACERR Gene

  • This gene represents transcription of a long non-coding RNA produced in antisense to the prostaglandin-endoperoxide synthase 2 (PTGS2) gene. This transcript interacts with NF-kB transcriptional regulators to promote expression of PTGS2. [provided by RefSeq, Feb 2015]

GeneCards Summary for PACERR Gene

PACERR (PTGS2 Antisense NFKB1 Complex-Mediated Expression Regulator RNA) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with PACERR include Central Hypoventilation Syndrome, Congenital and Vertebral Artery Occlusion.

Additional gene information for PACERR Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PACERR Gene

Genomics for PACERR Gene

Regulatory Elements for PACERR Gene

Enhancers for PACERR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H186617 1.5 FANTOM5 Ensembl ENCODE 6.6 -62.1 -62122 1 TBP CTCF MAX RAD21 BATF POLR3A POLR2A EED SMC3 ATF7 PTGS2 C1orf27 PACERR PLA2G4A GC01P186627 GC01P186626 LOC100131939
GH01H186678 1.2 ENCODE dbSUPER 8.2 +0.3 292 4 TBP SIN3A BRCA1 RAD21 RFX5 GLIS2 ELK1 ZNF366 ZNF143 RCOR1 PACERR LOC102724919 ENSG00000228238 PLA2G4A
GH01H186212 1.2 Ensembl ENCODE 4.4 -467.9 -467883 0 HDGF PKNOX1 FOXA2 RB1 NFIB ARNT SIN3A RAD21 RFX5 GATA2 TPR OCLM PACERR LOC105371654 ENSG00000224691
GH01H186762 0.7 ENCODE 7 +82.6 82635 2 CTCF PKNOX1 FOXA2 JUN JUNB RAD21 BATF EP300 STAT3 FOS PACERR PLA2G4A
GH01H186739 0.6 FANTOM5 7.1 +58.4 58366 0 JUNB RUNX3 BATF CREM SPI1 PTGS2 PLA2G4A PACERR C1orf27
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PACERR on UCSC Golden Path with GeneCards custom track

Promoters for PACERR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000017269 -22 2401 TBP SIN3A BRCA1 RAD21 RFX5 GLIS2 ZNF366 ELK1 ZNF143 RCOR1

Genomic Location for PACERR Gene

Chromosome:
1
Start:
186,680,622 bp from pter
End:
186,681,446 bp from pter
Size:
825 bases
Orientation:
Plus strand

Genomic View for PACERR Gene

Genes around PACERR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PACERR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PACERR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PACERR Gene

Proteins for PACERR Gene

Post-translational modifications for PACERR Gene

No Post-translational modifications

No data available for DME Specific Peptides for PACERR Gene

Domains & Families for PACERR Gene

Gene Families for PACERR Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PACERR: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for PACERR Gene

Function for PACERR Gene

Phenotypes From GWAS Catalog for PACERR Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PACERR Gene

Localization for PACERR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PACERR gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PACERR Gene

Pathways & Interactions for PACERR Gene

SuperPathways for PACERR Gene

No Data Available

Interacting Proteins for PACERR Gene

Gene Ontology (GO) - Biological Process for PACERR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PACERR Gene

Drugs & Compounds for PACERR Gene

No Compound Related Data Available

Transcripts for PACERR Gene

mRNA/cDNA for PACERR Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for PACERR Gene

No ASD Table

Relevant External Links for PACERR Gene

GeneLoc Exon Structure for
PACERR
ECgene alternative splicing isoforms for
PACERR

Expression for PACERR Gene

NURSA nuclear receptor signaling pathways regulating expression of PACERR Gene:

PACERR

Evidence on tissue expression from TISSUES for PACERR Gene

  • Heart(2.2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PACERR Gene

Orthologs for PACERR Gene

Evolution for PACERR Gene

ENSEMBL:
Gene Tree for PACERR (if available)
TreeFam:
Gene Tree for PACERR (if available)

No data available for Orthologs for PACERR Gene

Paralogs for PACERR Gene

No data available for Paralogs for PACERR Gene

Variants for PACERR Gene

Sequence variations from dbSNP and Humsavar for PACERR Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000395206 -- 186,679,521(+) ATCAA(C/T)TTTAC intron-variant, upstream-variant-2KB
rs1000781846 -- 186,680,425(+) AATTG(A/G)TCGCT upstream-variant-2KB, utr-variant-5-prime
rs1003511546 -- 186,681,943(+) CACAT(C/G)TGATT downstream-variant-500B, upstream-variant-2KB
rs1005230348 -- 186,680,592(+) GAAAT(A/G)AGAAA upstream-variant-2KB
rs1005305037 -- 186,681,095(+) GTACA(C/T)AGCTG nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PACERR Gene

Variant ID Type Subtype PubMed ID
esv2762854 CNV gain 21179565
nsv470750 CNV loss 18288195
nsv548403 CNV loss 21841781

Relevant External Links for PACERR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PACERR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PACERR Gene

Disorders for PACERR Gene

MalaCards: The human disease database

(2) MalaCards diseases for PACERR Gene - From: DISEASES

Disorder Aliases PubMed IDs
central hypoventilation syndrome, congenital
  • central hypoventilation syndrome, congenital, with or without hirschsprung disease
vertebral artery occlusion
  • occlusion and stenosis of vertebral artery
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for PACERR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PACERR
genes like me logo Genes that share disorders with PACERR: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PACERR Gene

Publications for PACERR Gene

  1. p50-associated COX-2 extragenic RNA (PACER) activates COX-2 gene expression by occluding repressive NF-κB complexes. (PMID: 24843008) Krawczyk M … Emerson BM (eLife 2014) 2 3 60
  2. P50-associated COX-2 extragenic RNA (PACER) overexpression promotes proliferation and metastasis of osteosarcoma cells by activating COX-2 gene. (PMID: 26476537) Qian M … Xiao J (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 3 60
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 60

Products for PACERR Gene

Sources for PACERR Gene

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