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Aliases for PABPN1L Gene

Aliases for PABPN1L Gene

  • Poly(A) Binding Protein Nuclear 1 Like, Cytoplasmic 2 3 5
  • Embryonic Poly(A)-Binding Protein Type II 3 4
  • Poly(A)-Binding Protein Nuclear-Like 1 3 4
  • Embryonic Poly(A)-Binding Protein 2 3 4
  • PABPNL1 3 4
  • EPABP-2 3 4
  • EPABP2 3 4
  • Poly(A) Binding Protein Nuclear 1 Like (Cytoplasmic) 2
  • Embryonic Polyadenylate-Binding Protein 2 3
  • Embryonic Poly(A) Binding Protein 2 2

External Ids for PABPN1L Gene

Previous GeneCards Identifiers for PABPN1L Gene

  • GC16M087456
  • GC16M088928
  • GC16M074625

Summaries for PABPN1L Gene

GeneCards Summary for PABPN1L Gene

PABPN1L (Poly(A) Binding Protein Nuclear 1 Like, Cytoplasmic) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Influenza A. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPN1.

UniProtKB/Swiss-Prot for PABPN1L Gene

  • Binds the poly(A) tail of mRNA.

Additional gene information for PABPN1L Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPN1L Gene

Genomics for PABPN1L Gene

Regulatory Elements for PABPN1L Gene

Enhancers for PABPN1L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H088967 1.9 FANTOM5 Ensembl ENCODE dbSUPER 14.3 -103.3 -103333 12 HDGF PKNOX1 ARNT SIN3A YBX1 ZNF766 CBX5 ZNF143 ZNF207 FOS ACSF3 PABPN1L LOC100129697 SNORD68 APRT ANKRD11 RPL13 ZNF778 ZC3H18 LOC101927863
GH16H089095 1.3 ENCODE dbSUPER 11.2 -229.5 -229459 8 PKNOX1 ATF1 ARNT SIN3A TCF12 ZNF121 ZNF766 CBX5 GATA2 ATF7 ACSF3 CDK10 CBFA2T3 LOC100129697 LINC02138 CDH15 PABPN1L SLC22A31 ENSG00000260279 PIR52081
GH16H088956 1.1 Ensembl ENCODE dbSUPER 11.7 -87.6 -87645 2 POLR2A ZMYM3 KDM1A RUNX3 ZNF7 SUPT5H PABPN1L CDK10 CBFA2T3 GALNS DEF8 PIR55515 PIR58575
GH16H089171 1.1 ENCODE dbSUPER 11.3 -303.8 -303752 4 HDAC1 HDGF PKNOX1 ARID4B GLIS2 EGR1 RCOR1 SP3 SP5 NFYC CDH15 ZNF778 ZC3H18 PABPN1L ACSF3 ENSG00000259877 ENSG00000260279 LINC00304 SLC22A31
GH16H088753 1 ENCODE dbSUPER 11.6 +115.1 115116 2 CTCF NFIB SIN3A RAD21 ZBTB40 E2F1 ZFHX2 CTBP1 GATA3 EGR1 PIEZO1 PABPN1L CDK10 SNAI3-AS1 GALNS LOC339059
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PABPN1L on UCSC Golden Path with GeneCards custom track

Genomic Location for PABPN1L Gene

Chromosome:
16
Start:
88,862,623 bp from pter
End:
88,870,156 bp from pter
Size:
7,534 bases
Orientation:
Minus strand

Genomic View for PABPN1L Gene

Genes around PABPN1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PABPN1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PABPN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPN1L Gene

Proteins for PABPN1L Gene

  • Protein details for PABPN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDY0-EPAB2_HUMAN
    Recommended name:
    Embryonic polyadenylate-binding protein 2
    Protein Accession:
    A6NDY0
    Secondary Accessions:
    • A1L3B3
    • A2VDI2

    Protein attributes for PABPN1L Gene

    Size:
    278 amino acids
    Molecular mass:
    30386 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PABPN1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PABPN1L Gene

Post-translational modifications for PABPN1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PABPN1L Gene

No data available for DME Specific Peptides for PABPN1L Gene

Domains & Families for PABPN1L Gene

Gene Families for PABPN1L Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PABPN1L Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PABPN1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PABPN1L: view

No data available for UniProtKB/Swiss-Prot for PABPN1L Gene

Function for PABPN1L Gene

Molecular function for PABPN1L Gene

UniProtKB/Swiss-Prot Function:
Binds the poly(A) tail of mRNA.

Phenotypes From GWAS Catalog for PABPN1L Gene

Gene Ontology (GO) - Molecular Function for PABPN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with PABPN1L: view

Phenotypes for PABPN1L Gene

MGI mutant phenotypes for PABPN1L:
inferred from 1 alleles
GenomeRNAi human phenotypes for PABPN1L:
genes like me logo Genes that share phenotypes with PABPN1L: view

Animal Models for PABPN1L Gene

MGI Knock Outs for PABPN1L:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PABPN1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PABPN1L Gene

Localization for PABPN1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for PABPN1L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PABPN1L gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for PABPN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PABPN1L: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PABPN1L Gene

Pathways & Interactions for PABPN1L Gene

genes like me logo Genes that share pathways with PABPN1L: view

Pathways by source for PABPN1L Gene

2 KEGG pathways for PABPN1L Gene

Gene Ontology (GO) - Biological Process for PABPN1L Gene

None

No data available for SIGNOR curated interactions for PABPN1L Gene

Drugs & Compounds for PABPN1L Gene

No Compound Related Data Available

Transcripts for PABPN1L Gene

mRNA/cDNA for PABPN1L Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPN1L Gene

Poly(A) binding protein, nuclear 1-like (cytoplasmic):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for PABPN1L
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for PABPN1L Gene

No ASD Table

Relevant External Links for PABPN1L Gene

GeneLoc Exon Structure for
PABPN1L
ECgene alternative splicing isoforms for
PABPN1L

Expression for PABPN1L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PABPN1L Gene

mRNA differential expression in normal tissues according to GTEx for PABPN1L Gene

This gene is overexpressed in Brain - Cerebellum (x8.5), Brain - Cerebellar Hemisphere (x6.5), and Adrenal Gland (x5.6).

Protein differential expression in normal tissues from HIPED for PABPN1L Gene

This gene is overexpressed in Liver (35.7) and Urine (33.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PABPN1L Gene



Protein tissue co-expression partners for PABPN1L Gene

NURSA nuclear receptor signaling pathways regulating expression of PABPN1L Gene:

PABPN1L

SOURCE GeneReport for Unigene cluster for PABPN1L Gene:

Hs.730522

mRNA Expression by UniProt/SwissProt for PABPN1L Gene:

A6NDY0-EPAB2_HUMAN
Tissue specificity: Expressed in various adult tissues.
genes like me logo Genes that share expression patterns with PABPN1L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PABPN1L Gene

Orthologs for PABPN1L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PABPN1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PABPN1L 33 34
  • 99 (n)
cow
(Bos Taurus)
Mammalia PABPN1L 33 34
  • 82.21 (n)
rat
(Rattus norvegicus)
Mammalia Pabpn1l 33
  • 75.5 (n)
mouse
(Mus musculus)
Mammalia Pabpn1l 33 16 34
  • 73.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PABPN1L 34
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PABPN1L 34
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves PABPN1L 34
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PABPN1L 34
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii pabpn1l 34
  • 42 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Pabp2 34
  • 40 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea pabp-2 34
  • 42 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGN1 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1647 34
  • 45 (a)
OneToMany
Species where no ortholog for PABPN1L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PABPN1L Gene

ENSEMBL:
Gene Tree for PABPN1L (if available)
TreeFam:
Gene Tree for PABPN1L (if available)

Paralogs for PABPN1L Gene

Paralogs for PABPN1L Gene

(1) SIMAP similar genes for PABPN1L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PABPN1L: view

Variants for PABPN1L Gene

Sequence variations from dbSNP and Humsavar for PABPN1L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000012962 -- 88,869,959(+) CCAGC(A/G)CCCAG utr-variant-5-prime
rs1000340685 -- 88,866,871(+) TCTTC(C/T)GCTTC upstream-variant-2KB, utr-variant-5-prime
rs1000393007 -- 88,866,666(+) GCGTC(C/T)GCACC upstream-variant-2KB, utr-variant-5-prime
rs1000674599 -- 88,867,769(+) GCACC(G/T)GCCAC intron-variant, upstream-variant-2KB
rs1000724791 -- 88,867,613(+) ACGGC(A/G)TGAGT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PABPN1L Gene

Variant ID Type Subtype PubMed ID
dgv3065n100 CNV gain 25217958
dgv37n68 CNV loss 17160897
esv2715064 CNV deletion 23290073
esv2715066 CNV deletion 23290073
esv3639555 CNV gain 21293372
esv3639561 CNV gain 21293372
nsv1061256 CNV gain 25217958
nsv1063024 CNV gain 25217958
nsv1928 CNV insertion 18451855
nsv471115 CNV loss 18288195
nsv482951 CNV loss 15286789
nsv521217 CNV loss 19592680
nsv573674 CNV gain 21841781
nsv952071 CNV deletion 24416366

Variation tolerance for PABPN1L Gene

Gene Damage Index Score: 3.20; 52.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PABPN1L Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PABPN1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPN1L Gene

Disorders for PABPN1L Gene

Relevant External Links for PABPN1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PABPN1L

No disorders were found for PABPN1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PABPN1L Gene

Publications for PABPN1L Gene

  1. Isolation of the human ePAB and ePABP2 cDNAs and analysis of the expression patterns. (PMID: 18483763) Sakugawa N … Sengoku K (Journal of assisted reproduction and genetics 2008) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 60
  4. Identification of a novel Xenopus laevis poly (A) binding protein. (PMID: 15380618) Cosson B … Beverley Osborne H (Biology of the cell 2004) 3 60
  5. Xenopus embryonic poly(A) binding protein 2 (ePABP2) defines a new family of cytoplasmic poly(A) binding proteins expressed during the early stages of vertebrate development. (PMID: 15083517) Good PJ … Sheets MD (Genesis (New York, N.Y. : 2000) 2004) 3 60

Products for PABPN1L Gene

Sources for PABPN1L Gene

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