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Aliases for PABPN1L Gene

Aliases for PABPN1L Gene

  • Poly(A) Binding Protein, Nuclear 1-Like (Cytoplasmic) 2 3
  • Embryonic Poly(A)-Binding Protein Type II 3 4
  • Poly(A)-Binding Protein Nuclear-Like 1 3 4
  • Embryonic Poly(A) Binding Protein 2 2 3
  • Embryonic Poly(A)-Binding Protein 2 3 4
  • PABPNL1 3 4
  • EPABP-2 3 4
  • EPABP2 3 4

External Ids for PABPN1L Gene

Previous GeneCards Identifiers for PABPN1L Gene

  • GC16M087456
  • GC16M088928
  • GC16M074625

Summaries for PABPN1L Gene

GeneCards Summary for PABPN1L Gene

PABPN1L (Poly(A) Binding Protein, Nuclear 1-Like (Cytoplasmic)) is a Protein Coding gene. Among its related pathways are Influenza A and mRNA surveillance pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPN1.

UniProtKB/Swiss-Prot for PABPN1L Gene

  • Binds the poly(A) tail of mRNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPN1L Gene

Genomics for PABPN1L Gene

Genomic Location for PABPN1L Gene

88,862,623 bp from pter
88,870,156 bp from pter
7,534 bases
Minus strand

Genomic View for PABPN1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PABPN1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPN1L Gene

No data available for Regulatory Elements for PABPN1L Gene

Proteins for PABPN1L Gene

  • Protein details for PABPN1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Embryonic polyadenylate-binding protein 2
    Protein Accession:
    Secondary Accessions:
    • A1L3B3
    • A2VDI2

    Protein attributes for PABPN1L Gene

    278 amino acids
    Molecular mass:
    30386 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PABPN1L Gene


neXtProt entry for PABPN1L Gene

Proteomics data for PABPN1L Gene at MOPED

Post-translational modifications for PABPN1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PABPN1L Gene

No data available for DME Specific Peptides for PABPN1L Gene

Domains & Families for PABPN1L Gene

Gene Families for PABPN1L Gene

Protein Domains for PABPN1L Gene


Suggested Antigen Peptide Sequences for PABPN1L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 RRM (RNA recognition motif) domain.
  • Contains 1 RRM (RNA recognition motif) domain.
genes like me logo Genes that share domains with PABPN1L: view

Function for PABPN1L Gene

Molecular function for PABPN1L Gene

UniProtKB/Swiss-Prot Function:
Binds the poly(A) tail of mRNA.

Gene Ontology (GO) - Molecular Function for PABPN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with PABPN1L: view

Phenotypes for PABPN1L Gene

MGI mutant phenotypes for PABPN1L:
inferred from 1 alleles
GenomeRNAi human phenotypes for PABPN1L:
genes like me logo Genes that share phenotypes with PABPN1L: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PABPN1L Gene

Localization for PABPN1L Gene

Subcellular locations from UniProtKB/Swiss-Prot for PABPN1L Gene


Gene Ontology (GO) - Cellular Components for PABPN1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PABPN1L: view

No data available for Subcellular locations from COMPARTMENTS for PABPN1L Gene

Pathways & Interactions for PABPN1L Gene

SuperPathways for PABPN1L Gene

genes like me logo Genes that share pathways with PABPN1L: view

Pathways by source for PABPN1L Gene

2 KEGG pathways for PABPN1L Gene

Interacting Proteins for PABPN1L Gene

Gene Ontology (GO) - Biological Process for PABPN1L Gene


No data available for SIGNOR curated interactions for PABPN1L Gene

Drugs & Compounds for PABPN1L Gene

No Compound Related Data Available

Transcripts for PABPN1L Gene

mRNA/cDNA for PABPN1L Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPN1L Gene

Poly(A) binding protein, nuclear 1-like (cytoplasmic):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PABPN1L Gene

No ASD Table

Relevant External Links for PABPN1L Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PABPN1L Gene

mRNA expression in normal human tissues for PABPN1L Gene

mRNA differential expression in normal tissues according to GTEx for PABPN1L Gene

This gene is overexpressed in Brain - Cerebellum (x8.5), Brain - Cerebellar Hemisphere (x6.5), and Adrenal Gland (x5.6).

Protein differential expression in normal tissues from HIPED for PABPN1L Gene

This gene is overexpressed in Liver (35.7) and Urine (33.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PABPN1L Gene

SOURCE GeneReport for Unigene cluster for PABPN1L Gene Hs.730522

mRNA Expression by UniProt/SwissProt for PABPN1L Gene

Tissue specificity: Expressed in various adult tissues.
genes like me logo Genes that share expression patterns with PABPN1L: view

Protein tissue co-expression partners for PABPN1L Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PABPN1L Gene

Orthologs for PABPN1L Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PABPN1L Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PABPN1L 35
  • 82.21 (n)
  • 73.88 (a)
  • 64 (a)
(Mus musculus)
Mammalia Pabpn1l 35
  • 73.41 (n)
  • 68.01 (a)
Pabpn1l 16
Pabpn1l 36
  • 62 (a)
(Pan troglodytes)
Mammalia PABPN1L 35
  • 99 (n)
  • 98.12 (a)
  • 87 (a)
(Rattus norvegicus)
Mammalia Pabpn1l 35
  • 75.5 (n)
  • 71.64 (a)
(Monodelphis domestica)
Mammalia PABPN1L 36
  • 53 (a)
(Ornithorhynchus anatinus)
Mammalia PABPN1L 36
  • 55 (a)
(Gallus gallus)
Aves PABPN1L 36
  • 47 (a)
(Anolis carolinensis)
Reptilia PABPN1L 36
  • 60 (a)
(Danio rerio)
Actinopterygii pabpn1l 36
  • 42 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pabp2 36
  • 40 (a)
(Caenorhabditis elegans)
Secernentea pabp-2 36
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SGN1 36
  • 19 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1647 36
  • 45 (a)
Species with no ortholog for PABPN1L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PABPN1L Gene

Gene Tree for PABPN1L (if available)
Gene Tree for PABPN1L (if available)

Paralogs for PABPN1L Gene

Paralogs for PABPN1L Gene

(1) SIMAP similar genes for PABPN1L Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PABPN1L: view

Variants for PABPN1L Gene

Sequence variations from dbSNP and Humsavar for PABPN1L Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs889753 -- 88,865,506(-) ACCAG(A/G)GGGTC intron-variant
rs3859021 -- 88,864,740(-) AGGCA(C/T)GGTGC intron-variant
rs3859022 -- 88,864,715(-) ACAGG(A/T)TGTGG intron-variant
rs7342794 -- 88,867,741(+) ACCCG(C/T)GTCCG upstream-variant-2KB, intron-variant
rs8047407 -- 88,868,498(+) atact(C/T)gggag upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PABPN1L Gene

Variant ID Type Subtype PubMed ID
nsv907226 CNV Loss 21882294
nsv907268 CNV Loss 21882294
dgv2979n71 CNV Loss 21882294
nsv907278 CNV Loss 21882294
dgv2989n71 CNV Gain 21882294
dgv2990n71 CNV Loss 21882294
dgv37n68 CNV Loss 17160897
dgv2992n71 CNV Loss 21882294
dgv2996n71 CNV Loss 21882294
nsv471115 CNV Loss 18288195
nsv521217 CNV Loss 19592680
nsv907352 CNV Loss 21882294
dgv2997n71 CNV Loss 21882294
dgv2998n71 CNV Loss 21882294
nsv907357 CNV Loss 21882294
nsv907358 CNV Loss 21882294
nsv907359 CNV Loss 21882294
esv2715064 CNV Deletion 23290073
esv2715066 CNV Deletion 23290073
nsv1928 CNV Insertion 18451855

Variation tolerance for PABPN1L Gene

Gene Damage Index Score: 3.20; 52.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PABPN1L Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPN1L Gene

Disorders for PABPN1L Gene

Relevant External Links for PABPN1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PABPN1L: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PABPN1L Gene

Publications for PABPN1L Gene

  1. Isolation of the human ePAB and ePABP2 cDNAs and analysis of the expression patterns. (PMID: 18483763) Sakugawa N. … Sengoku K. (J. Assist. Reprod. Genet. 2008) 2 67
  2. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 67
  3. Identification of a novel Xenopus laevis poly (A) binding protein. (PMID: 15380618) Cosson B. … Beverley Osborne H. (Biol. Cell 2004) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Xenopus embryonic poly(A) binding protein 2 (ePABP2) defines a new family of cytoplasmic poly(A) binding proteins expressed during the early stages of vertebrate development. (PMID: 15083517) Good P.J. … Sheets M.D. (Genesis 2004) 67

Products for PABPN1L Gene

Sources for PABPN1L Gene

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