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Aliases for PABPC5 Gene

Aliases for PABPC5 Gene

  • Poly(A) Binding Protein, Cytoplasmic 5 2 3
  • PABP5 3 4 6
  • Poly(A)-Binding Protein, Cytoplasmic 5 2
  • Polyadenylate-Binding Protein 5 3
  • Poly(A)-Binding Protein 5 4
  • PABP-5 4

External Ids for PABPC5 Gene

Summaries for PABPC5 Gene

Entrez Gene Summary for PABPC5 Gene

  • This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010]

GeneCards Summary for PABPC5 Gene

PABPC5 (Poly(A) Binding Protein, Cytoplasmic 5) is a Protein Coding gene. Among its related pathways are RNA transport and Deadenylation-dependent mRNA decay. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is PABPC1.

UniProtKB/Swiss-Prot for PABPC5 Gene

  • Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC5 Gene

Genomics for PABPC5 Gene

Genomic Location for PABPC5 Gene

Start:
91,434,595 bp from pter
End:
91,438,584 bp from pter
Size:
3,990 bases
Orientation:
Plus strand

Genomic View for PABPC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PABPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC5 Gene

Regulatory Elements for PABPC5 Gene

Proteins for PABPC5 Gene

  • Protein details for PABPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DU9-PABP5_HUMAN
    Recommended name:
    Polyadenylate-binding protein 5
    Protein Accession:
    Q96DU9
    Secondary Accessions:
    • A8K240
    • Q5JQF4
    • Q6P529
    • Q9UFE5

    Protein attributes for PABPC5 Gene

    Size:
    382 amino acids
    Molecular mass:
    43331 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PABPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PABPC5 Gene

Proteomics data for PABPC5 Gene at MOPED

Post-translational modifications for PABPC5 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys102 and Lys111

Other Protein References for PABPC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PABPC5 Gene

Domains for PABPC5 Gene

Gene Families for PABPC5 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for PABPC5 Gene

UniProtKB/Swiss-Prot:

PABP5_HUMAN
Domain:
  • Contains 4 RRM (RNA recognition motif) domains.:
    • Q96DU9
genes like me logo Genes that share domains with PABPC5: view

Function for PABPC5 Gene

Molecular function for PABPC5 Gene

UniProtKB/Swiss-Prot Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

Gene Ontology (GO) - Molecular Function for PABPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with PABPC5: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PABPC5 Gene

Localization for PABPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PABPC5 Gene

Cytoplasm.
Isoform 2: Mitochondrion matrix. Note=Co-fractionates with mtDNA and co-immunoprecipitates with the mitochondrial poly(A) polymerase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PABPC5 Gene COMPARTMENTS Subcellular localization image for PABPC5 gene
Compartment Confidence
nucleus 3
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PABPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with PABPC5: view

Pathways for PABPC5 Gene

genes like me logo Genes that share pathways with PABPC5: view

Pathways by source for PABPC5 Gene

3 KEGG pathways for PABPC5 Gene

Gene Ontology (GO) - Biological Process for PABPC5 Gene

None

Transcripts for PABPC5 Gene

mRNA/cDNA for PABPC5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPC5 Gene

Poly(A) binding protein, cytoplasmic 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC5 Gene

No ASD Table

Relevant External Links for PABPC5 Gene

GeneLoc Exon Structure for
PABPC5
ECgene alternative splicing isoforms for
PABPC5

Expression for PABPC5 Gene

mRNA expression in normal human tissues for PABPC5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PABPC5 Gene

SOURCE GeneReport for Unigene cluster for PABPC5 Gene Hs.246590

mRNA Expression by UniProt/SwissProt for PABPC5 Gene

Q96DU9-PABP5_HUMAN
Tissue specificity: Expressed in fetal brain and in a range of adult tissues
genes like me logo Genes that share expressions with PABPC5: view

Orthologs for PABPC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PABPC5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PABPC5 36
  • 99.91 (n)
  • 100 (a)
PABPC5 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC511286 36
  • 91.95 (n)
  • 96.85 (a)
PABPC5 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PABPC5 36
  • 92.65 (n)
  • 96.85 (a)
PABPC5 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pabpc5 36
  • 88.74 (n)
  • 95.51 (a)
Pabpc5 16
Pabpc5 37
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 53 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pabpc5 36
  • 89.24 (n)
  • 95.54 (a)
zebrafish
(Danio rerio)
Actinopterygii pabpc4 37
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4612 38
  • 44 (a)
Species with no ortholog for PABPC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PABPC5 Gene

ENSEMBL:
Gene Tree for PABPC5 (if available)
TreeFam:
Gene Tree for PABPC5 (if available)

Paralogs for PABPC5 Gene

Selected SIMAP similar genes for PABPC5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PABPC5: view

Variants for PABPC5 Gene

Sequence variations from dbSNP and Humsavar for PABPC5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4609354 -- 91,438,459(+) TCATA(A/T)TTTTT utr-variant-3-prime
rs5940963 -- 91,438,902(+) ATTTT(A/T)CTGAG downstream-variant-500B
rs5941912 -- 91,438,664(+) AATTT(A/G)TATGA downstream-variant-500B
rs36010332 -- 91,438,243(+) ATAAA(-/G)ATAAT utr-variant-3-prime
rs41312558 -- 91,438,247(+) AAATA(A/T)TGACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PABPC5 Gene

Variant ID Type Subtype PubMed ID
nsv528258 CNV Gain 19592680
nsv521121 CNV Gain 19592680
nsv526620 CNV Gain 19592680
nsv516611 CNV Gain 19592680

Relevant External Links for PABPC5 Gene

HapMap Linkage Disequilibrium report
PABPC5
Locus Specific Mutation Databases (LSDB)
PABPC5

Disorders for PABPC5 Gene

(1) University of Copenhagen DISEASES for PABPC5 Gene

genes like me logo Genes that share disorders with PABPC5: view

No data available for UniProtKB/Swiss-Prot for PABPC5 Gene

Publications for PABPC5 Gene

  1. A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21.3/Yp11.2 homology block of the human sex chromosomes. (PMID: 11374897) Blanco P. … Affara N.A. (Genomics 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. HIV- 1 protease inhibits Cap- and poly(A)-dependent translation upon eIF4GI and PABP cleavage. (PMID: 19956697) CastellA^ A. … Carrasco L. (PLoS ONE 2009) 3

Products for PABPC5 Gene

Sources for PABPC5 Gene

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