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PABPC5 Gene

protein-coding   GIFtS: 50

GC0XP090576
poly(A) binding protein, cytoplasmic 5
(Previous names: poly(A)-binding protein, cytoplasmic 5 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
OTTHUMP00000023637 2
PABP5 1, 2, 3, 5
Descriptions
PABP 5 3
Poly(A)-binding protein 5 3
poly(A) binding protein, cytoplasmic 5 2
poly(A)-binding protein, cytoplasmic 5 1
External Ids
HGNC: 136291
Entrez Gene: 1408862
UniProtKB: Q96DU93
Ensembl: ENSG000001747407
Search outside databases for aliases for PABPC5 gene

Previous GC identifers: GC0XP085962 GC0XP087658 GC0XP088725 GC0XP089461 GC0XP090495

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PABP5_HUMAN, Q96DU9
Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of
mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By
similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the PABPC5 gene  

Entrez Gene cytogenetic band: Xq21.3   Ensembl cytogenetic band:  Xq21.31   HGNC cytogenetic band: Xq21.3

PABPC5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP090576:     (about GC identifiers)

Start:
90,576,250 bp from pter
End:
90,580,239 bp from pter
Size:
3,990 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000023.9  NT_011651.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PABP5_HUMAN, Q96DU9 (See protein sequence)
Recommended Name: Polyadenylate-binding protein 5  
Size: 382 amino acids; 43331 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q5JQF4 Q6P529 Q9UFE5

REFSEQ proteins: NP_543022.1  

ENSEMBL proteins: 
ENSP00000362197 ENSP00000308012 ENSP00000385644 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (PABPC5)
Human Recombinant Proteins from Abnova (PABPC5)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

1 Gene Ontology (GO) cellular component term (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm IEA--
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Antibodies for PABPC5: 
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Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for PABPC5
Browse R&D Systems for Antibodies
Antibodies from Abcam (PABPC5), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (PABPC5)
Novus Biologicals Antibody for PABPC5

Assays for PABPC5: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro domains/families:
 IPR000504 RRM_RNP1
 IPR012677 a_b_plait_nuc_bd


   GeneDecks  PABPC5 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q96DU9

ProtoNet protein and cluster: Q96DU9

1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

UniProtKB/Swiss-Prot: PABP5_HUMAN, Q96DU9
Similarity: Contains 4 RRM (RNA recognition motif) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (PABPC5)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (PABPC5)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080832

              Applied Biosystems Silencer® siRNAs for PABPC5

              Sigma-Aldrich siRNA for PABPC5  
                     Sigma-Aldrich shRNA for PABPC5  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for PABPC5
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_080832
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_080832
                                 untagged cDNA clone in CMV expression vector: NM_080832 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_080832

UniProtKB/Swiss-Prot: PABP5_HUMAN, Q96DU9
Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of
mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By
similarity)

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0003723 RNA binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



4 Interacting proteins for PABPC5 (ENSP000003080123) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
TGIF2LYENSP000003725213STRING (score=.943)
TGIF2LXENSP000003551193STRING (score=.942)
PCDH11XENSP000003621863STRING (score=.932)
TGIF2ENSP000003629793STRING (score=.868)
About this table
(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PABPC5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (PABPC5)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (PABPC5)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080832

              Sigma-Aldrich siRNA for PABPC5  
                     Sigma-Aldrich shRNA for PABPC5  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_080832  

REFSEQ mRNAs for PABPC5 gene: 

NM_080832.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_080832  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_080832
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_080832
                                 untagged cDNA clone in CMV expression vector: NM_080832 

Additional cDNA sequence: 

AK290105.1 AK297327.1 AL122118.1 BC063113.1 CR602574.1 

2 DOTS entries:

DT.404965  DT.91685474 

14 AceView cDNA sequences:

BX324644 AA927586 CR602574 AL122118 BX105503 NM_080832 BC063113 CD657700 
AA670223 AW088092 BG570501 BU596402 BX324643 BG210271 

highest scoring ESTs for PABPC5:

AA670223 AL122118 BC063113 BG570501 BX105503 AA927586 AW088092 BG210271 BU596402 BX324643 

Unigene Cluster for PABPC5:

Poly(A) binding protein, cytoplasmic 5
Hs.246590  [show with all ESTs]
Unigene Representative Sequence: NM_080832


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:
ENST00000373105  ENST00000312600  ENST00000402906  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PABPC5 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for PABPC5

1 / 2 / 3

3 probe-sets matching PABPC5 gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

87791_at2, 3 U95-D 1 1.00 1.00 1.00 1.00 AA670223 0.80 1.00 0.91 1

233136_at2, 3 U133-B 2 1.00 0.95 -- -- AL122118 0.80 1.00 0.91 1

233136_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CTCATTGTAA

SOURCE GeneReport for Unigene cluster: Hs.246590

UniProtKB/Swiss-Prot: PABP5_HUMAN, Q96DU9
Tissue specificity: Expressed in fetal brain and in a range of adult tissues

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for PABPC5 gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
PABPC51   -- poly(A) binding protein, cytoplasmic 5 92.65(n)
96.85(a)
492002  XM_549122.2  XP_549122.2 
chimpanzee
(Pan troglodytes)
PABPC51   -- poly(A) binding protein, cytoplasmic 5 99.91(n)
100(a)
465742  XM_521163.2  XP_521163.2 
cow
(Bos taurus)
PABPC51   -- poly(A) binding protein, cytoplasmic 5 91.95(n)
96.85(a)
511286  XM_588593.3  XP_588593.2 
rat
(Rattus norvegicus)
LOC3027681   -- similar to poly A binding protein, cytoplasmic 5 89.24(n)
95.54(a)
302768  XM_229071.3  XP_229071.1 
mouse
(Mus musculus)
Pabpc51, 5 X5
poly(A) binding protein, cytoplasmic 55
poly A binding protein, cytoplasmic 51
88.74(n)1
95.51(a)1
937281  NM_053114.21  NP_444344.11 
 AJ2990845  AK0505515  (see all 9)
About this table        Species with no ortholog for PABPC5

ENSEMBL Gene Tree for PABPC5
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for PABPC5 gene
PABPC1L2  PABPC32  PABPC1L2B2  PABPCP52  PABPCP22  PABPC42  PABPC1L2A2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/27 NCBI SNPs in PABPC5 are shown (see all 27 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 30)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs70500771,2
A,C,F,H90578173(+) AATCAA/GTGATG 1 N/S mis18Minor allele frequency- G:0.01EU EA WA 628
--
rs59409631,2
C,F,H90580557(+) ATTTTT/ACTGAG 1 -- ng318Minor allele frequency- A:0.11EU EA WA 702
--
rs46093541,2
A,C,F90580114(+) TCATAT/ATTTTT 1 -- ut313Minor allele frequency- A:0.44NA 142
rs128357951,2
C,F,H90575010(+) GTAAAA/CCCCAT 1 -- ng518Minor allele frequency- C:0.03EU EA WA 628
--
rs120145831,2
A,F,H90574391(+) ctacaA/Gatgaa 1 -- ng514Minor allele frequency- G:0.42EU EA WA 420
rs128361631,2
C,F,H90575522(+) TCCTTC/TAAGGG 1 -- ng518Minor allele frequency- T:0.04EU EA WA 717
rs128575761,2
F,H90574532(+) tatgcC/Tatctg 1 -- ng514Minor allele frequency- T:0.01EU EA WA 400
rs48931521,2
A90575599(+) TTCATA/CTGTAA 1 -- ng51 tfbs30--------
--
rs59419121,2
A90580319(+) aatttA/Gtatga 1 -- ng310--------
rs44680811,2
A,C,F,H90576730(+) GGCTAG/CCCAGC 1 -- int17Minor allele frequency- C:0.48EU EA WA NA 531
About this table

HapMap Linkage Disequilibrium images for PABPC5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300407

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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5 PubMed articles for PABPC5 gene:
(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 140886 HGNC: 13629 AceView: PABPC5 Ensembl:ENSG00000174740 euGenes: HUgn140886
ECgene: PABPC5 H-InvDB: PABPC5
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for PABPC5:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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 Predesigned and custom siRNAs for PABPC5 Antibodies for PABPC5
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for PABPC5 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for PABPC5

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