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Aliases for PABPC5 Gene

Aliases for PABPC5 Gene

  • Poly(A) Binding Protein, Cytoplasmic 5 2 3
  • PABP5 3 4
  • Poly(A)-Binding Protein, Cytoplasmic 5 2
  • Poly(A)-Binding Protein 5 4
  • PABP-5 4

External Ids for PABPC5 Gene

Previous GeneCards Identifiers for PABPC5 Gene

  • GC0XP085962
  • GC0XP087658
  • GC0XP088725
  • GC0XP089461
  • GC0XP090495
  • GC0XP090576
  • GC0XP090689

Summaries for PABPC5 Gene

Entrez Gene Summary for PABPC5 Gene

  • This gene encodes a protein that binds to the polyA tail found at the 3' end of most eukaryotic mRNAs. It is thought to play a role in the regulation of mRNA metabolic processes in the cytoplasm. This gene is located in a gene-poor region within the X-specific 13d-sY43 subinterval of the chromosome Xq21.3/Yp11.2 homology block. It is located close to translocation breakpoints associated with premature ovarian failure, and is therefore a potential candidate gene for this disorder. [provided by RefSeq, May 2010]

GeneCards Summary for PABPC5 Gene

PABPC5 (Poly(A) Binding Protein, Cytoplasmic 5) is a Protein Coding gene. Diseases associated with PABPC5 include ovary serous adenocarcinoma and ovarian cystadenocarcinoma. Among its related pathways are RNA transport and Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC1.

UniProtKB/Swiss-Prot for PABPC5 Gene

  • Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC5 Gene

Genomics for PABPC5 Gene

Regulatory Elements for PABPC5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PABPC5 Gene

Chromosome:
X
Start:
91,434,595 bp from pter
End:
91,438,584 bp from pter
Size:
3,990 bases
Orientation:
Plus strand

Genomic View for PABPC5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PABPC5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC5 Gene

Proteins for PABPC5 Gene

  • Protein details for PABPC5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DU9-PABP5_HUMAN
    Recommended name:
    Polyadenylate-binding protein 5
    Protein Accession:
    Q96DU9
    Secondary Accessions:
    • A8K240
    • Q5JQF4
    • Q6P529
    • Q9UFE5

    Protein attributes for PABPC5 Gene

    Size:
    382 amino acids
    Molecular mass:
    43331 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PABPC5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PABPC5 Gene

Proteomics data for PABPC5 Gene at MOPED

Post-translational modifications for PABPC5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PABPC5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PABPC5 Gene

Domains & Families for PABPC5 Gene

Gene Families for PABPC5 Gene

Protein Domains for PABPC5 Gene

Suggested Antigen Peptide Sequences for PABPC5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DU9

UniProtKB/Swiss-Prot:

PABP5_HUMAN :
  • Contains 4 RRM (RNA recognition motif) domains.
Domain:
  • Contains 4 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with PABPC5: view

Function for PABPC5 Gene

Molecular function for PABPC5 Gene

UniProtKB/Swiss-Prot Function:
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

Gene Ontology (GO) - Molecular Function for PABPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with PABPC5: view

Phenotypes for PABPC5 Gene

GenomeRNAi human phenotypes for PABPC5:
genes like me logo Genes that share phenotypes with PABPC5: view

Animal Model Products

miRNA for PABPC5 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PABPC5 Gene

Localization for PABPC5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PABPC5 Gene

Cytoplasm.
Isoform 2: Mitochondrion matrix. Note=Co-fractionates with mtDNA and co-immunoprecipitates with the mitochondrial poly(A) polymerase.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PABPC5 Gene COMPARTMENTS Subcellular localization image for PABPC5 gene
Compartment Confidence
mitochondrion 3

Gene Ontology (GO) - Cellular Components for PABPC5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with PABPC5: view

Pathways & Interactions for PABPC5 Gene

genes like me logo Genes that share pathways with PABPC5: view

Pathways by source for PABPC5 Gene

3 KEGG pathways for PABPC5 Gene

Gene Ontology (GO) - Biological Process for PABPC5 Gene

None

No data available for SIGNOR curated interactions for PABPC5 Gene

Drugs & Compounds for PABPC5 Gene

No Compound Related Data Available

Transcripts for PABPC5 Gene

mRNA/cDNA for PABPC5 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPC5 Gene

Poly(A) binding protein, cytoplasmic 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC5 Gene

No ASD Table

Relevant External Links for PABPC5 Gene

GeneLoc Exon Structure for
PABPC5
ECgene alternative splicing isoforms for
PABPC5

Expression for PABPC5 Gene

mRNA expression in normal human tissues for PABPC5 Gene

Protein differential expression in normal tissues from HIPED for PABPC5 Gene

This gene is overexpressed in Ovary (68.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PABPC5 Gene



SOURCE GeneReport for Unigene cluster for PABPC5 Gene Hs.246590

mRNA Expression by UniProt/SwissProt for PABPC5 Gene

Q96DU9-PABP5_HUMAN
Tissue specificity: Expressed in fetal brain and in a range of adult tissues
genes like me logo Genes that share expression patterns with PABPC5: view

Protein tissue co-expression partners for PABPC5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PABPC5 Gene

Orthologs for PABPC5 Gene

This gene was present in the common ancestor of animals.

Orthologs for PABPC5 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC511286 35
  • 91.95 (n)
  • 96.85 (a)
PABPC5 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PABPC5 35
  • 92.65 (n)
  • 96.85 (a)
PABPC5 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pabpc5 35
  • 88.74 (n)
  • 95.51 (a)
Pabpc5 16
Pabpc5 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PABPC5 35
  • 99.91 (n)
  • 100 (a)
PABPC5 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pabpc5 35
  • 89.24 (n)
  • 95.54 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 53 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pabpc4 36
  • 40 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4612 37
  • 44 (a)
Species with no ortholog for PABPC5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PABPC5 Gene

ENSEMBL:
Gene Tree for PABPC5 (if available)
TreeFam:
Gene Tree for PABPC5 (if available)

Paralogs for PABPC5 Gene

(8) SIMAP similar genes for PABPC5 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PABPC5: view

Variants for PABPC5 Gene

Sequence variations from dbSNP and Humsavar for PABPC5 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4609354 -- 91,438,459(+) TCATA(A/T)TTTTT utr-variant-3-prime
rs5940963 -- 91,438,902(+) ATTTT(A/T)CTGAG downstream-variant-500B
rs5941912 -- 91,438,664(+) AATTT(A/G)TATGA downstream-variant-500B
rs36010332 -- 91,438,243(+) ATAAA(-/G)ATAAT utr-variant-3-prime
rs41312558 -- 91,438,247(+) AAATA(A/T)TGACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PABPC5 Gene

Variant ID Type Subtype PubMed ID
nsv528258 CNV Gain 19592680
nsv521121 CNV Gain 19592680
nsv526620 CNV Gain 19592680
nsv516611 CNV Gain 19592680

Variation tolerance for PABPC5 Gene

Residual Variation Intolerance Score: 24.56% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.86; 18.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PABPC5 Gene

HapMap Linkage Disequilibrium report
PABPC5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPC5 Gene

Disorders for PABPC5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for PABPC5 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ovary serous adenocarcinoma
  • malignant ovarian serous tumor
ovarian cystadenocarcinoma
  • cystadenocarcinoma of the ovary
- elite association

Relevant External Links for PABPC5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PABPC5
genes like me logo Genes that share disorders with PABPC5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PABPC5 Gene

Publications for PABPC5 Gene

  1. A novel poly(A)-binding protein gene (PABPC5) maps to an X-specific subinterval in the Xq21.3/Yp11.2 homology block of the human sex chromosomes. (PMID: 11374897) Blanco P. … Affara N.A. (Genomics 2001) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Alternative translation initiation augments the human mitochondrial proteome. (PMID: 23275553) Kazak L. … Holt I.J. (Nucleic Acids Res. 2013) 67
  4. Genetically distinct subsets within ANCA-associated vasculitis. (PMID: 22808956) Lyons P.A. … Smith K.G. (N. Engl. J. Med. 2012) 67
  5. Depletion of nuclear poly(A) binding protein PABPN1 produces a compensatory response by cytoplasmic PABP4 and PABP5 in cultured human cells. (PMID: 23300856) Bhattacharjee R.B. … Bag J. (PLoS ONE 2012) 67

Products for PABPC5 Gene

Sources for PABPC5 Gene

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