 |
 | Services
| |
 |
Aliases & Descriptions for PABPC5
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| OTTHUMP00000023637 2 | | PABP5 1, 2, 3, 5 |
| | | Descriptions |
|---|
| PABP 5 3 | | Poly(A)-binding protein 5 3 | | poly(A) binding protein, cytoplasmic 5 2 | | poly(A)-binding protein, cytoplasmic 5 1 |
|
| | Search outside databases for aliases for PABPC5 genePrevious GC identifers: GC0XP085962 GC0XP087658 GC0XP088725 GC0XP089461 GC0XP090495 |
Summaries for PABPC5(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: PABP5_HUMAN, Q96DU9Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity) |
Genomic Location for PABPC5
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PABPC5 gene 
Entrez Gene cytogenetic band: Xq21.3 Ensembl cytogenetic band: Xq21.31 HGNC cytogenetic band: Xq21.3PABPC5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP090576:
(about GC identifiers)
Start:
|
90,576,250 bp from pter |
End:
|
90,580,239 bp from pter |
Size:
|
3,990 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000023.9 NT_011651.16
| Proteins for PABPC5
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PABP5_HUMAN, Q96DU9 (See
protein sequence)Recommended Name: Polyadenylate-binding protein 5 Size: 382 amino acids; 43331 Da
Subcellular location: Cytoplasm (By similarity)
Secondary accessions: Q5JQF4 Q6P529 Q9UFE5REFSEQ proteins: NP_543022.1
ENSEMBL proteins: ENSP00000362197 ENSP00000308012 ENSP00000385644
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- | About this table
Antibodies for PABPC5: Assays for PABPC5: | Protein
Domains/ Families for PABPC5(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q96DU9
ProtoNet protein and cluster: Q96DU9 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: PABP5_HUMAN, Q96DU9Similarity: Contains 4 RRM (RNA recognition motif) domains | Gene Function for PABPC5
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080832
Applied Biosystems Silencer® siRNAs for PABPC5
Sigma-Aldrich siRNA for PABPC5  Sigma-Aldrich shRNA for PABPC5  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_080832                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_080832                                  untagged cDNA clone in CMV expression vector: NM_080832 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_080832
UniProtKB/Swiss-Prot: PABP5_HUMAN, Q96DU9Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity)2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000166 | nucleotide binding |
IEA | -- | | GO:0003723 | RNA binding |
IEA | -- | About this table | Pathways & Interactions for PABPC5
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for PABPC5 (ENSP000003080123) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds for PABPC5(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for PABPC5
|
Transcripts for PABPC5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_080832
Sigma-Aldrich siRNA for PABPC5  Sigma-Aldrich shRNA for PABPC5  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_080832 REFSEQ mRNAs for PABPC5 gene: NM_080832.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_080832               OriGene GFP tagged cDNA clone in CMV expression vector: NM_080832                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_080832                                  untagged cDNA clone in CMV expression vector: NM_080832  Additional cDNA sequence: AK290105.1 AK297327.1 AL122118.1 BC063113.1 CR602574.1 2 DOTS entries: DT.404965 DT.91685474 14 AceView cDNA sequences:BX324644 AA927586 CR602574 AL122118 BX105503 NM_080832 BC063113 CD657700 AA670223 AW088092 BG570501 BU596402 BX324643 BG210271
highest scoring ESTs for PABPC5:AA670223 AL122118 BC063113 BG570501 BX105503 AA927586 AW088092 BG210271 BU596402 BX324643 Unigene Cluster for PABPC5: Poly(A) binding protein, cytoplasmic 5 Hs.246590 [show with all ESTs]Unigene Representative Sequence: NM_080832
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations: ENST00000373105
ENST00000312600
ENST00000402906
|
Expression for PABPC5
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PABPC5 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PABPC5
1 / 2 / 3 3 probe-sets matching PABPC5 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CTCATTGTAA
SOURCE GeneReport for Unigene cluster: Hs.246590 UniProtKB/Swiss-Prot: PABP5_HUMAN, Q96DU9Tissue specificity: Expressed in fetal brain and in a range of adult tissues |
Orthologs for PABPC5
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PABPC5 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for PABPC5
ENSEMBL Gene Tree for PABPC5 | Paralogs for PABPC5(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for PABPC5 gene
- PABPC1L2 PABPC32 PABPC1L2B2 PABPCP52 PABPCP22 PABPC42 PABPC1L2A2
|
SNPs/Variants for PABPC5(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PABPC5 (up to first 250kb)
|
Disorders & Mutations for PABPC5
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 300407
|
Medical News for PABPC5(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PABPC5 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 5 PubMed articles for PABPC5 gene: |
Search for PABPC5
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PABPC5
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PABPC5
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PABPC5(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PABPC5(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for PABPC5:

 | |
 | | | | |
|
 |  |  |
| | | | Search Tocris compounds for PABPC5 |
|
 |
 | | | |
GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
|