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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PABPC4L Gene

protein-coding   GIFtS: 44
GCID: GC04M135117

Poly(A) Binding Protein, Cytoplasmic 4-Like

  Search for PABPC4L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Poly(A) Binding Protein, Cytoplasmic 4-Like1 2
PABP-4-like2 3
Polyadenylate-Binding Protein 4-Like2
Poly(A)-Binding Protein 4-Like3

External Ids:    HGNC: 319551   Entrez Gene: 1324302   Ensembl: ENSG000002545357   UniProtKB: P0CB383   

Export aliases for PABPC4L gene to outside databases

Previous GC identifers: GC00U921646 GC04M135336 GC04M130845


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for PABPC4L Gene: 
PABPC4L (poly(A) binding protein, cytoplasmic 4-like) is a protein-coding gene. Among its related super-pathways are Deadenylation-dependent mRNA decay. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is PABPC1L.

UniProtKB/Swiss-Prot: PAB4L_HUMAN, P0CB38
Function: May bind RNA (Potential)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PABPC4L gene promoter:
         AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   STAT5A   Nkx2-5   POU3F2   C/EBPalpha   CHOP-10   E2F-1   E2F   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PABPC4L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PABPC4L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28.3   Ensembl cytogenetic band:  4q28.3   HGNC cytogenetic band: 4q28.3

PABPC4L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PABPC4L gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M135117:  view genomic region     (about GC identifiers)

Start:
135,117,488 bp from pter      End:
135,122,903 bp from pter
Size:
5,416 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: PAB4L_HUMAN, P0CB38 (See protein sequence)
Recommended Name: Polyadenylate-binding protein 4-like  
Size: 370 amino acids; 41854 Da

Explore the universe of human proteins at neXtProt for PABPC4L: NX_P0CB38

Explore proteomics data for PABPC4L at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0CB38

  • PABPC4L Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    PABPC4L Protein Expression
    REFSEQ proteins: NP_001108206.2  
    ENSEMBL proteins: 
     ENSP00000463233   ENSP00000462986  

    Human Recombinant Protein Products for PABPC4L: 
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    Cloud-Clone Corp. Proteins for PABPC4L 


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom
     IPR006515 PABP_1234

    Graphical View of Domain Structure for InterPro Entry P0CB38

    ProtoNet protein and cluster: P0CB38

    UniProtKB/Swiss-Prot: PAB4L_HUMAN, P0CB38
    Similarity: Belongs to the polyadenylate-binding protein type-1 family
    Similarity: Contains 4 RRM (RNA recognition motif) domains


    PABPC4L for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PAB4L_HUMAN, P0CB38
    Function: May bind RNA (Potential)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
         
    PABPC4L for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for PABPC4L:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for PABPC4L 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for PABPC4L

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PABPC4L 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for PABPC4L 

    miRNA
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    Inhib. RNA
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    Gene Editing
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for PABPC4L About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.49
    2mRNA surveillance pathway
    mRNA surveillance pathway
    3RNA transport
    RNA transport

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3         Kegg Pathways  (Kegg details for PABPC4L):
        RNA transport
    mRNA surveillance pathway
    RNA degradation


    PABPC4L for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PABPC4L

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PABPC4L (PAB4L)

    Search CenterWatch for drugs/clinical trials and news about PABPC4L / PAB4L

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for PABPC4L gene: 
    NM_001114734.1  

    Unigene Cluster for PABPC4L:

    Poly(A) binding protein, cytoplasmic 4-like
    Hs.49889  [show with all ESTs]
    Unigene Representative Sequence: NM_001114734
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421491 ENST00000529122(uc010ioe.3)
    miRNA
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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate PABPC4L (see all 20):
    hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-137 hsa-miR-3942-5p hsa-miR-4305 hsa-miR-944 hsa-miR-124 hsa-miR-9
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for PABPC4L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PABPC4L
    Clone
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    GenScript: all cDNA clones in your preferred vector: PABPC4L (NM_001114734)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat PABPC4L
    Sirion Biotech Customized lentivirus for stable overexpression of PABPC4L 
                         Customized lentivirus expression plasmids for stable overexpression of PABPC4L 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PABPC4L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PABPC4L

    Additional mRNA sequence: 

    AY672099.1 BX648831.1 

    2 DOTS entries:

    DT.206747  DT.121269272 

    13 AceView cDNA sequences:

    BX648831 BU681868 N70553 AI445657 AI822078 AI822134 BX119056 W05423 
    BU154086 AW195490 BF239151 AA342991 BE564206 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PABPC4L expression in normal human tissues (normalized intensities)      PABPC4L embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTCTCAATAT
    PABPC4L Expression
    About this image


    PABPC4L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/9 selected tissues (see all 9) fully expand
     
     Blood Brain Barrier (Nervous System)
             Postnatal Endothelial Cells Blood Brain Barrier
     
     Umbilical Cord (Extraembryonic Tissues)
             Umbilical cord blood-derived mesenchymal stem cells
     
     Endothelium (Cardiovascular System)
             Postnatal Endothelial Cells Blood Brain Barrier
     
     Placenta (Extraembryonic Tissues)
             Placenta Pericyte   
     
     Blood (Hematopoietic System)
             Umbilical cord blood-derived mesenchymal stem cells

    See PABPC4L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PABPC4L

    SOURCE GeneReport for Unigene cluster: Hs.49889
        SABiosciences Custom PCR Arrays for PABPC4L
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PABPC4L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for PABPC4L gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pabpc4l1 , 5 poly(A) binding protein, cytoplasmic 4-like1, 5 81.26(n)1
    81.35(a)1
      3 (20.74 cM)5
    2419891  NM_001101479.11  NP_001094949.11 
     464421975 
    fruit fly
    (Drosophila melanogaster)
    Insecta pAbp6
    polyA-binding protein
    36(a)
    1 → many
    2R(14027583-14034696)
    worm
    (Caenorhabditis elegans)
    Secernentea pab-16
    pab-26
    Protein PAB-2, isoform a
    33(a)
    30(a)
    many ↔ many
    many ↔ many
    I(10432815-10435876)
    X(13522849-13527415)


    ENSEMBL Gene Tree for PABPC4L (if available)
    TreeFam Gene Tree for PABPC4L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PABPC4L gene
    PABPC1L2  PABPC52  PABPC42  ELAVL12  ELAVL42  RBMS12  ELAVL32  RBMS32  
    PABPC32  PABPC1L2B2  ELAVL22  PABPC1L2A2  RBMS22  PABPC12  
    14 SIMAP similar genes for PABPC4L using alignment to 3 protein entries:     PAB4L_HUMAN (see all proteins):
    PABPC4    PABPC3    PABPC1L    PABPC1    PABPC1L2A    PABPC1L2B
    PABPC5    RBMY1A1    ELAVL2    MYEF2    SF3B4    RBMS1
    HNRNPA1    TIAL1

    PABPC4L for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/117 SNPs in PABPC4L are shown (see all 117)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1869079831,2
    --135117217(+) GACAGG/TTTAGT 1 -- ds50010--------
    rs352947751,2
    C,F--135117398(+) AAAAAC/TACAAG 1 -- ds50012Minor allele frequency- T:0.50NA 4
    rs1145529051,2
    C,F--135117802(+) TTCTAC/TTTATT 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs1440121051,2
    C--135117818(+) AGGCAA/CTTGGG 1 -- ut310--------
    rs778900871,2
    C,F--135117860(+) ATCTCT/GATTTT 1 -- ut311Minor allele frequency- G:0.04WA 118
    rs119380531,2
    C,F,H--135117888(+) TATTAA/TCACGC 1 -- ut3110Minor allele frequency- T:0.39NA WA CSA EA 373
    rs1903132501,2
    --135117893(+) TCACGC/TACCAA 1 -- ut310--------
    rs2012085241,2
    --135117960(+) TGTAA-/ACTG  
            
    ACTGT
    1 -- ut310--------
    rs613486241,2
    C--135117970(+) CTGTC-/TTTTTT 1 -- ut310--------
    rs784169061,2
    C,F--135118097(+) ACATAC/TATGAA 1 -- ut311Minor allele frequency- T:0.05EA 120

    HapMap Linkage Disequilibrium report for PABPC4L (135117488 - 135122903 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for PABPC4L:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv880073CNV Loss21882294
    nsv520680CNV Loss19592680
    nsv880056CNV Loss21882294
    dgv5747n71CNV Loss21882294
    nsv880075CNV Loss21882294
    nsv461648CNV Loss19166990
    nsv880074CNV Loss21882294
    dgv5746n71CNV Loss21882294
    dgv5745n71CNV Loss21882294
    nsv880079CNV Gain21882294


    Human Gene Mutation Database (HGMD): PABPC4L
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing PABPC4L
    DNA2.0 Custom Variant and Variant Library Synthesis for PABPC4L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PABPC4L for disorders           About MalaCards

    PABPC4L for disorders           About GeneDecksing

    Genetic Association Database (GAD): PABPC4L

    Export disorders for PABPC4L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PABPC4L gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PABPC4L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    2. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    3. Genome-wide association study of coronary heart disea se and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PubMed id 21347282)4 Lettre G....Boerwinkle E. (2011)
    4. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    5. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    6. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (2007)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    9. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 132430 HGNC: 31955 AceView: LOC132430 Ensembl:ENSG00000254535 euGenes: HUgn132430
    ECgene: PABPC4L Kegg: 132430 H-InvDB: PABPC4L

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PABPC4L Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for PABPC4L gene:
    Search GeneIP for patents involving PABPC4L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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