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Aliases for PABPC4L Gene

Aliases for PABPC4L Gene

  • Poly(A) Binding Protein, Cytoplasmic 4-Like 2 3
  • PABP-4-Like 3 4
  • Polyadenylate-Binding Protein 4-Like 3
  • Poly(A)-Binding Protein 4-Like 4

External Ids for PABPC4L Gene

Previous GeneCards Identifiers for PABPC4L Gene

  • GC00U921646
  • GC04M135336
  • GC04M135117
  • GC04M130845

Summaries for PABPC4L Gene

GeneCards Summary for PABPC4L Gene

PABPC4L (Poly(A) Binding Protein, Cytoplasmic 4-Like) is a Protein Coding gene. Among its related pathways are RNA transport and Deadenylation-dependent mRNA decay. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is PABPC1.

UniProtKB/Swiss-Prot for PABPC4L Gene

  • May bind RNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC4L Gene

Genomics for PABPC4L Gene

Regulatory Elements for PABPC4L Gene

Genomic Location for PABPC4L Gene

Start:
134,196,333 bp from pter
End:
134,201,748 bp from pter
Size:
5,416 bases
Orientation:
Minus strand

Genomic View for PABPC4L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PABPC4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC4L Gene

Proteins for PABPC4L Gene

  • Protein details for PABPC4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CB38-PAB4L_HUMAN
    Recommended name:
    Polyadenylate-binding protein 4-like
    Protein Accession:
    P0CB38
    Secondary Accessions:

    Protein attributes for PABPC4L Gene

    Size:
    370 amino acids
    Molecular mass:
    41854 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PABPC4L Gene

Proteomics data for PABPC4L Gene at MOPED

Post-translational modifications for PABPC4L Gene

  • Ubiquitination at Lys107
  • Modification sites at PhosphoSitePlus

Other Protein References for PABPC4L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PABPC4L Gene

Domains for PABPC4L Gene

Gene Families for PABPC4L Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for PABPC4L Gene

Suggested Antigen Peptide Sequences for PABPC4L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CB38

UniProtKB/Swiss-Prot:

PAB4L_HUMAN :
  • P0CB38
Domain:
  • Contains 4 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the polyadenylate-binding protein type-1 family.
genes like me logo Genes that share domains with PABPC4L: view

Function for PABPC4L Gene

Molecular function for PABPC4L Gene

UniProtKB/Swiss-Prot Function: May bind RNA.

Gene Ontology (GO) - Molecular Function for PABPC4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with PABPC4L: view

Phenotypes for PABPC4L Gene

GenomeRNAi human phenotypes for PABPC4L:
genes like me logo Genes that share phenotypes with PABPC4L: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PABPC4L Gene

Localization for PABPC4L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PABPC4L Gene COMPARTMENTS Subcellular localization image for PABPC4L gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PABPC4L Gene

Pathways for PABPC4L Gene

genes like me logo Genes that share pathways with PABPC4L: view

Pathways by source for PABPC4L Gene

3 KEGG pathways for PABPC4L Gene

Interacting Proteins for PABPC4L Gene

Gene Ontology (GO) - Biological Process for PABPC4L Gene

None

Transcripts for PABPC4L Gene

mRNA/cDNA for PABPC4L Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPC4L Gene

Poly(A) binding protein, cytoplasmic 4-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC4L Gene

No ASD Table

Relevant External Links for PABPC4L Gene

GeneLoc Exon Structure for
PABPC4L
ECgene alternative splicing isoforms for
PABPC4L

Expression for PABPC4L Gene

mRNA expression in normal human tissues for PABPC4L Gene

mRNA differential expression in normal tissues according to GTEx for PABPC4L Gene

This gene is overexpressed in Heart - Atrial Appendage (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for PABPC4L Gene

SOURCE GeneReport for Unigene cluster for PABPC4L Gene Hs.49889

genes like me logo Genes that share expressions with PABPC4L: view

No data available for mRNA Expression by UniProt/SwissProt for PABPC4L Gene

Orthologs for PABPC4L Gene

This gene was present in the common ancestor of chordates.

Orthologs for PABPC4L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PABPC4L 35
  • 99.53 (n)
  • 99.53 (a)
cow
(Bos Taurus)
Mammalia LOC101908085 35
  • 88.35 (n)
  • 89.7 (a)
dog
(Canis familiaris)
Mammalia PABPC4L 35
  • 71.54 (n)
  • 73.98 (a)
mouse
(Mus musculus)
Mammalia Pabpc4l 35
  • 81.26 (n)
  • 81.35 (a)
Pabpc4l 16
Pabpc4l 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pabpc4l 35
  • 80.99 (n)
  • 81.89 (a)
zebrafish
(Danio rerio)
Actinopterygii pabpc4 36
  • 46 (a)
OneToMany
Species with no ortholog for PABPC4L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PABPC4L Gene

ENSEMBL:
Gene Tree for PABPC4L (if available)
TreeFam:
Gene Tree for PABPC4L (if available)

Paralogs for PABPC4L Gene

Selected SIMAP similar genes for PABPC4L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PABPC4L: view

Variants for PABPC4L Gene

Sequence variations from dbSNP and Humsavar for PABPC4L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1014107 -- 134,202,718(+) CAGTT(G/T)TACTT upstream-variant-2KB
rs2044116 -- 134,200,213(+) CGCTC(G/T)ACTTT synonymous-codon, reference
rs2421217 -- 134,199,509(+) TTTAG(G/T)TGTAA utr-variant-3-prime
rs2421218 -- 134,203,157(+) ACCCA(C/T)TGGGG upstream-variant-2KB
rs3930916 -- 134,203,260(+) TGGGA(A/C)TAAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for PABPC4L Gene

Variant ID Type Subtype PubMed ID
nsv880056 CNV Loss 21882294
dgv5745n71 CNV Loss 21882294
dgv5746n71 CNV Loss 21882294
nsv520680 CNV Loss 19592680
nsv880073 CNV Loss 21882294
nsv880074 CNV Loss 21882294
nsv880075 CNV Loss 21882294
dgv5747n71 CNV Loss 21882294
nsv461648 CNV Loss 19166990
nsv880079 CNV Gain 21882294

Relevant External Links for PABPC4L Gene

HapMap Linkage Disequilibrium report
PABPC4L
Human Gene Mutation Database (HGMD)
PABPC4L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPC4L Gene

Disorders for PABPC4L Gene

Relevant External Links for PABPC4L

Genetic Association Database (GAD)
PABPC4L
genes like me logo Genes that share disorders with PABPC4L: view

No data available for UniProtKB/Swiss-Prot for PABPC4L Gene

Publications for PABPC4L Gene

  1. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3
  2. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3

Products for PABPC4L Gene

Sources for PABPC4L Gene

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