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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

PABPC4L Gene

protein-coding   GIFtS: 41
GCID: GC04M135117

poly(A) binding protein, cytoplasmic 4-like
  Search for PABPC4L
in
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 Human Malady Compendium 
Biological research products
for PABPC4L    

Aliases
for PABPC4L gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Poly(A) Binding Protein, Cytoplasmic 4-Like1 2
PABP-4-Like1
Polyadenylate-Binding Protein 4-Like2
Poly(A)-Binding Protein 4-Like3

External Ids:    HGNC: 319551   Entrez Gene: 1324302   Ensembl: ENSG000002545357   UniProtKB: P0CB383   

Export aliases for PABPC4L gene to outside databases

Previous GC identifers: GC00U921646 GC04M135336 GC04M130845


Summaries
for PABPC4L gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: PAB4L_HUMAN, P0CB38
Function: May bind RNA (Potential)




Genomic Views
for PABPC4L gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PABPC4L gene promoter:
         AML1a   POU3F2 (N-Oct-5b)   POU3F2 (N-Oct-5a)   STAT5A   Nkx2-5   POU3F2   C/EBPalpha   CHOP-10   E2F-1   E2F   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for PABPC4L

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PABPC4L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q28.3   Ensembl cytogenetic band:  4q28.3   HGNC cytogenetic band: 4q28.3

PABPC4L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PABPC4L gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M135117:  view genomic region     (about GC identifiers)

Start:
 135,117,488 bp from pter      End:
 135,122,903 bp from pter
Size:
 5,416 bases      Orientation:
 minus strand

Proteins
for PABPC4L gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PAB4L_HUMAN, P0CB38 (See protein sequence)
Recommended Name: Polyadenylate-binding protein 4-like  
Size: 370 amino acids; 41854 Da

Explore the universe of human proteins at neXtProt for PABPC4L: NX_P0CB38

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P0CB38

    • PABPC4L Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001108206.2  
    ENSEMBL proteins: 
     ENSP00000463233   ENSP00000462986  

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    Protein Domains /
    Families
    for PABPC4L gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    PABPC4L for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom
     IPR006515 PABP_1234

    Graphical View of Domain Structure for InterPro Entry P0CB38

    ProtoNet protein and cluster: P0CB38

    UniProtKB/Swiss-Prot: PAB4L_HUMAN, P0CB38
    Similarity: Belongs to the polyadenylate-binding protein type-1 family
    Similarity: Contains 4 RRM (RNA recognition motif) domains


    Function
    for PABPC4L gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PAB4L_HUMAN, P0CB38
    Function: May bind RNA (Potential)

    miRNA
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    hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-137 hsa-miR-3942-5p hsa-miR-4305 hsa-miR-944 hsa-miR-124 hsa-miR-9
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003723RNA binding IEA--


    PABPC4L for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for PABPC4L:
     Synthetic lethal with Ras 


    Pathways & Interactions
    for PABPC4L gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1mRNA surveillance pathway
    		mRNA surveillance pathway1.00
    2RNA transport
    		RNA transport1.00
    3Deadenylation-dependent mRNA decay
    		RNA degradation0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    3         Kegg Pathways  (Kegg details for PABPC4L):
        RNA transport
    mRNA surveillance pathway
    RNA degradation


    PABPC4L for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PABPC4L

    Drugs & Compounds
    for PABPC4L gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PABPC4L
    Search CenterWatch for drugs/clinical trials and news about PABPC4L / PAB4L 

    Transcripts
    for PABPC4L gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for PABPC4L gene: 
    NM_001114734.1  

    Unigene Cluster for PABPC4L:

    Poly(A) binding protein, cytoplasmic 4-like
    Hs.49889  [show with all ESTs]
    Unigene Representative Sequence: NM_001114734
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000421491 ENST00000529122(uc010ioe.3)

    miRNA
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    8/20 QIAGEN miScript miRNA Assays for microRNAs that regulate PABPC4L (see all 20):
    hsa-miR-361-5p hsa-miR-3607-3p hsa-miR-137 hsa-miR-3942-5p hsa-miR-4305 hsa-miR-944 hsa-miR-124 hsa-miR-9
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PABPC4L (see all 7)
    OriGene shRNA RFP: PABPC4L
    OriGene siRNA: PABPC4L
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PABPC4L
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PABPC4L
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PABPC4L

    Additional cDNA sequence: 

    AY672099.1 BX648831.1 

    2 DOTS entries:

    DT.206747  DT.121269272 

    13 AceView cDNA sequences:

    AI445657 N70553 BU681868 BX648831 AI822134 W05423 AI822078 BU154086 
    BX119056 AW195490 AA342991 BF239151 BE564206 

    GeneLoc Exon Structure


    Expression
    for PABPC4L gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    PABPC4L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCTCAATAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    PABPC4L expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor E44 (Embryonic Progenitor Cell)
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See PABPC4L Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for PABPC4L

    SOURCE GeneReport for Unigene cluster: Hs.49889
        SABiosciences Custom PCR Arrays for PABPC4L
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PABPC4L

    Orthologs
    for PABPC4L gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PABPC4L gene from 5/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves --
    		 Uncharacterized protein
    		 31(a)
    		 1 → many
    		 2(133697091-133738561)
    fruit fly
    (Drosophila melanogaster)    		 Insecta pAbp6
    CG46126
    		 --
    		 36(a)
    30(a)
    		 1 ↔ many
    possible ortholog
    		 2R(14027583-14034696)
    2R(20409397-20413612)
    worm
    (Caenorhabditis elegans)    		 Secernentea pab-16
    pab-26
    		 PolyA Binding protein family member (pab-2)
    		 33(a)
    30(a)
    		 many ↔ many
    many ↔ many
    		 I(10432806-10435867)
    X(13522779-13527345)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons PAB16
    PAB86
    (see all 6)    		 poly(A) binding protein 8
    (see all 6)    		 33(a)
    28(a)
    (see all 6)    		 possible ortholog
    possible ortholog
    (see all 6)    		 1(12433356-12434735)
    1(18416474-18420083)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 polyadenylate-binding protein, putative, expressed...
    polyadenylate-binding protein, putative, expressed...
    (see all 4)    		 28(a)
    27(a)
    (see all 4)    		 possible ortholog
    possible ortholog
    (see all 4)    		 8(13469297-13476757)
    6(23134706-23140106)


    ENSEMBL Gene Tree for PABPC4L (if available)
    TreeFam Gene Tree for PABPC4L (if available) 

    Paralogs
    for PABPC4L gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for PABPC4L gene
    PABPC1L2  PABPC52  PABPC42  ELAVL12  RBMS12  ELAVL42  ELAVL32  RBMS32  
    PABPC32  ELAVL22  PABPC1L2B2  PABPC1L2A2  PUF602  RBMS22  PABPC12  
    15 SIMAP similar genes for PABPC4L using alignment to 3 protein entries:     PAB4L_HUMAN (see all proteins):
    PABPC4    PABPC3    PABPC1L    PABPC1    PABPC1L2A    PABPC1L2B
    PABPC5    RBMY1A1    ELAVL2    MYEF2    SF3B4    RBMS1
    HNRNPA1    TIAL1    HNRNPD

    PABPC4L for paralogs           About GeneDecksing



    Genomic Variants
    for PABPC4L gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PABPC4L
         1 CNV: 34621
    Human Gene Mutation Database (HGMD): PABPC4L
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PABPC4L
    DNA2.0 Custom Variant and Variant Library Synthesis for PABPC4L

    Disorders / Diseases
    for PABPC4L gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    PABPC4L for disorders           About MalaCards

    PABPC4L for disorders           About GeneDecksing


    Export disorders for PABPC4L gene to outside databases

    Publications
    for PABPC4L gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for PABPC4L gene integrated from 9 sources:
    (articles sorted by number of sources associating them with PABPC4L)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    2. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    5. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

    External Searches for PABPC4L gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing PABPC4L gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 132430 HGNC: 31955 AceView: LOC132430 Ensembl:ENSG00000254535 euGenes: HUgn132430
    ECgene: PABPC4L Kegg: 132430 H-InvDB: PABPC4L

    Other Databases showing PABPC4L gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing PABPC4L gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for PABPC4L Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for PABPC4L gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for PABPC4L gene:
    Search GeneIP for patents involving PABPC4L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for PABPC4L gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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    Advanced Cell Diagnostics
    About This Section

     
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