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Aliases for PABPC4L Gene

Aliases for PABPC4L Gene

  • Poly(A) Binding Protein Cytoplasmic 4 Like 2 3 5
  • PABP-4-Like 3 4
  • Poly(A) Binding Protein, Cytoplasmic 4-Like 2
  • Polyadenylate-Binding Protein 4-Like 3
  • Poly(A)-Binding Protein 4-Like 4

External Ids for PABPC4L Gene

Previous GeneCards Identifiers for PABPC4L Gene

  • GC00U921646
  • GC04M135336
  • GC04M135117
  • GC04M130845

Summaries for PABPC4L Gene

GeneCards Summary for PABPC4L Gene

PABPC4L (Poly(A) Binding Protein Cytoplasmic 4 Like) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC4.

UniProtKB/Swiss-Prot for PABPC4L Gene

  • May bind RNA.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC4L Gene

Genomics for PABPC4L Gene

Regulatory Elements for PABPC4L Gene

Enhancers for PABPC4L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F134200 0.7 ENCODE 6.6 +0.2 171 2.0 SOX13 L3MBTL2 CEBPB ZNF384 CEBPG THRB PPARG ZNF217 GATA3 ATF4 PABPC4L ENSG00000251388
GH04F134544 0.6 ENCODE 4.5 -342.7 -342733 0.2 PKNOX1 STAT1 SIN3A EP300 RAD21 HIC1 JUND STAT3 TRIM28 PABPC4L LOC105377436 LOC105377434
GH04F134552 0.4 ENCODE 4.5 -350.6 -350563 0.1 BCL11A POU5F1 PABPC4L LOC105377434 LOC105377436 GC04P134581
GH04F134198 0.2 Ensembl 0.8 +2.7 2748 0.8 PABPC4L ENSG00000251388
GH04F134078 0.6 Ensembl 0.1 +123.2 123248 0.6 ZNF143 JUNB MLLT1 TBX21 ZBTB40 ENSG00000251388 PABPC4L
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PABPC4L on UCSC Golden Path with GeneCards custom track

Promoters for PABPC4L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001249793 447 2199 SOX13 L3MBTL2 CEBPB ZNF384 THRB PPARG BCL6 ZNF24 RXRB

Genomic Location for PABPC4L Gene

Chromosome:
4
Start:
134,196,333 bp from pter
End:
134,201,748 bp from pter
Size:
5,416 bases
Orientation:
Minus strand

Genomic View for PABPC4L Gene

Genes around PABPC4L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PABPC4L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PABPC4L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC4L Gene

Proteins for PABPC4L Gene

  • Protein details for PABPC4L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CB38-PAB4L_HUMAN
    Recommended name:
    Polyadenylate-binding protein 4-like
    Protein Accession:
    P0CB38

    Protein attributes for PABPC4L Gene

    Size:
    370 amino acids
    Molecular mass:
    41854 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PABPC4L Gene

Post-translational modifications for PABPC4L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PABPC4L Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PABPC4L Gene

Domains & Families for PABPC4L Gene

Gene Families for PABPC4L Gene

Protein Domains for PABPC4L Gene

Suggested Antigen Peptide Sequences for PABPC4L Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CB38

UniProtKB/Swiss-Prot:

PAB4L_HUMAN :
  • Contains 4 RRM (RNA recognition motif) domains.
  • Belongs to the polyadenylate-binding protein type-1 family.
Domain:
  • Contains 4 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the polyadenylate-binding protein type-1 family.
genes like me logo Genes that share domains with PABPC4L: view

Function for PABPC4L Gene

Molecular function for PABPC4L Gene

UniProtKB/Swiss-Prot Function:
May bind RNA.

Gene Ontology (GO) - Molecular Function for PABPC4L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with PABPC4L: view

Phenotypes for PABPC4L Gene

GenomeRNAi human phenotypes for PABPC4L:
genes like me logo Genes that share phenotypes with PABPC4L: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PABPC4L Gene

Localization for PABPC4L Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for PABPC4L Gene

Pathways & Interactions for PABPC4L Gene

genes like me logo Genes that share pathways with PABPC4L: view

Pathways by source for PABPC4L Gene

3 KEGG pathways for PABPC4L Gene

Interacting Proteins for PABPC4L Gene

Selected Interacting proteins: P0CB38-PAB4L_HUMAN for PABPC4L Gene via IID

Gene Ontology (GO) - Biological Process for PABPC4L Gene

None

No data available for SIGNOR curated interactions for PABPC4L Gene

Transcripts for PABPC4L Gene

mRNA/cDNA for PABPC4L Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPC4L Gene

Poly(A) binding protein, cytoplasmic 4-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC4L Gene

No ASD Table

Relevant External Links for PABPC4L Gene

GeneLoc Exon Structure for
PABPC4L
ECgene alternative splicing isoforms for
PABPC4L

Expression for PABPC4L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PABPC4L Gene

mRNA differential expression in normal tissues according to GTEx for PABPC4L Gene

This gene is overexpressed in Heart - Atrial Appendage (x4.4).

Protein differential expression in normal tissues from HIPED for PABPC4L Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (56.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PABPC4L Gene



NURSA nuclear receptor signaling pathways regulating expression of PABPC4L Gene:

PABPC4L

SOURCE GeneReport for Unigene cluster for PABPC4L Gene:

Hs.49889
genes like me logo Genes that share expression patterns with PABPC4L: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PABPC4L Gene

Orthologs for PABPC4L Gene

This gene was present in the common ancestor of chordates.

Orthologs for PABPC4L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PABPC4L 34
  • 99.53 (n)
cow
(Bos Taurus)
Mammalia LOC101908085 34
  • 88.35 (n)
mouse
(Mus musculus)
Mammalia Pabpc4l 34 16 35
  • 81.26 (n)
rat
(Rattus norvegicus)
Mammalia Pabpc4l 34
  • 80.99 (n)
dog
(Canis familiaris)
Mammalia PABPC4L 34
  • 71.54 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pabpc4 35
  • 46 (a)
OneToMany
Species where no ortholog for PABPC4L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PABPC4L Gene

ENSEMBL:
Gene Tree for PABPC4L (if available)
TreeFam:
Gene Tree for PABPC4L (if available)

Paralogs for PABPC4L Gene

(14) SIMAP similar genes for PABPC4L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PABPC4L: view

Variants for PABPC4L Gene

Sequence variations from dbSNP and Humsavar for PABPC4L Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10000682 -- 133,951,554(+) gacag(A/G)atcaa intron-variant
rs10001760 -- 134,152,524(+) CCTCC(A/G)AAACC intron-variant
rs10001946 -- 134,122,676(+) TAAAA(G/T)GGAAC intron-variant
rs10002132 -- 133,957,009(+) tcaaa(C/T)catat intron-variant
rs10004749 -- 134,049,285(+) AATAG(C/T)AGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PABPC4L Gene

Variant ID Type Subtype PubMed ID
nsv595493 CNV loss 21841781
nsv520680 CNV loss 19592680
nsv461648 CNV loss 19166990
nsv1026397 CNV loss 25217958
esv3602304 CNV loss 21293372
esv3569699 CNV loss 25503493
esv3569696 CNV loss 25503493
dgv9277n54 CNV loss 21841781
dgv9276n54 CNV loss 21841781
dgv9275n54 CNV loss 21841781
dgv5397n100 CNV loss 25217958

Variation tolerance for PABPC4L Gene

Gene Damage Index Score: 2.17; 39.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PABPC4L Gene

Human Gene Mutation Database (HGMD)
PABPC4L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PABPC4L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPC4L Gene

Disorders for PABPC4L Gene

Relevant External Links for PABPC4L

Genetic Association Database (GAD)
PABPC4L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PABPC4L

No disorders were found for PABPC4L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PABPC4L Gene

Publications for PABPC4L Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  3. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. (PMID: 23754948) Randall J.C. … Heid I.M. (PLoS Genet. 2013) 3 64
  4. Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project. (PMID: 21347282) Lettre G. … Boerwinkle E. (PLoS Genet. 2011) 46 64
  5. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64

Products for PABPC4L Gene

Sources for PABPC4L Gene

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