Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PABPC4 Gene

Aliases for PABPC4 Gene

  • Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form) 2 3
  • PABP4 3 4 6
  • IPABP 3 4 6
  • APP1 3 4 6
  • Inducible Poly(A)-Binding Protein 3 4
  • Activated-Platelet Protein 1 3 4
  • Poly(A)-Binding Protein 4 3 4
  • PABP-4 3 4
  • APP-1 3 4
  • Poly(A)-Binding Protein, Cytoplasmic 4 (Inducible Form) 2
  • Polyadenylate-Binding Protein 4 3

External Ids for PABPC4 Gene

Summaries for PABPC4 Gene

Entrez Gene Summary for PABPC4 Gene

  • Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for PABPC4 Gene

PABPC4 (Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form)) is a Protein Coding gene. Among its related pathways are RNA transport and Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleotide binding and poly(U) RNA binding. An important paralog of this gene is PABPC1.

UniProtKB/Swiss-Prot for PABPC4 Gene

  • Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

Gene Wiki entry for PABPC4 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC4 Gene

Genomics for PABPC4 Gene

Genomic Location for PABPC4 Gene

Start:
39,560,813 bp from pter
End:
39,576,849 bp from pter
Size:
16,037 bases
Orientation:
Minus strand

Genomic View for PABPC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PABPC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC4 Gene

Regulatory Elements for PABPC4 Gene

Proteins for PABPC4 Gene

  • Protein details for PABPC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13310-PABP4_HUMAN
    Recommended name:
    Polyadenylate-binding protein 4
    Protein Accession:
    Q13310
    Secondary Accessions:
    • B1ANQ8
    • Q4VC03
    • Q6P0N3

    Protein attributes for PABPC4 Gene

    Size:
    644 amino acids
    Molecular mass:
    70783 Da
    Quaternary structure:
    • Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with NFX1.

    Alternative splice isoforms for PABPC4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PABPC4 Gene

Proteomics data for PABPC4 Gene at MOPED

Post-translational modifications for PABPC4 Gene

  • Arg-518 is dimethylated, probably to asymmetric dimethylarginine
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys78, Lys108, Lys113, Lys129, Lys157, Lys188, Lys196, Lys216, Lys299, Lys312, Lys333, Lys348, Lys361, and Lys375

No data available for DME Specific Peptides for PABPC4 Gene

Domains for PABPC4 Gene

Gene Families for PABPC4 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

UniProtKB/Swiss-Prot:

PABP4_HUMAN
Domain:
  • Contains 1 PABC domain.:
    • Q13310
  • Contains 4 RRM (RNA recognition motif) domains.:
    • Q13310
Family:
  • Belongs to the polyadenylate-binding protein type-1 family.:
    • Q13310
genes like me logo Genes that share domains with PABPC4: view

Function for PABPC4 Gene

Molecular function for PABPC4 Gene

GENATLAS Biochemistry: poly (A) binding nuclear protein,cytoplasmic 4,inducible,detected in activated human T cells and activated platelets,PABPC1 homolog
UniProtKB/Swiss-Prot Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity).

Gene Ontology (GO) - Molecular Function for PABPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0005515 protein binding IPI 11369516
GO:0008143 poly(A) binding IDA 8524242
genes like me logo Genes that share ontologies with PABPC4: view
genes like me logo Genes that share phenotypes with PABPC4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PABPC4 Gene

Localization for PABPC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PABPC4 Gene

Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PABPC4 Gene COMPARTMENTS Subcellular localization image for PABPC4 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for PABPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21940797
GO:0005737 cytoplasm IDA --
GO:0010494 cytoplasmic stress granule IDA 21940797
GO:0030529 ribonucleoprotein complex IDA 17289661
genes like me logo Genes that share ontologies with PABPC4: view

Pathways for PABPC4 Gene

genes like me logo Genes that share pathways with PABPC4: view

Pathways by source for PABPC4 Gene

3 KEGG pathways for PABPC4 Gene

Gene Ontology (GO) - Biological Process for PABPC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006396 RNA processing TAS 8524242
GO:0006401 RNA catabolic process TAS 8524242
GO:0006412 translation TAS 8524242
GO:0007596 blood coagulation TAS 9030741
genes like me logo Genes that share ontologies with PABPC4: view

Transcripts for PABPC4 Gene

Unigene Clusters for PABPC4 Gene

Poly(A) binding protein, cytoplasmic 4 (inducible form):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ·
SP1: - - - - -
SP2: - - - -
SP3: - - - -
SP4: -
SP5: -
SP6: - -
SP7: - -
SP8: -
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15: -

ExUns: 12d · 12e ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - - - -
SP6:
SP7:
SP8: - - -
SP9:
SP10:
SP11: -
SP12:
SP13: - - -
SP14:
SP15:

Relevant External Links for PABPC4 Gene

GeneLoc Exon Structure for
PABPC4
ECgene alternative splicing isoforms for
PABPC4

Expression for PABPC4 Gene

mRNA expression in normal human tissues for PABPC4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PABPC4 Gene

This gene is overexpressed in Muscle - Skeletal (6.1) and Pancreas (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PABPC4 Gene

SOURCE GeneReport for Unigene cluster for PABPC4 Gene Hs.169900

mRNA Expression by UniProt/SwissProt for PABPC4 Gene

Q13310-PABP4_HUMAN
Tissue specificity: Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA levels are rapidly up-regulated
genes like me logo Genes that share expressions with PABPC4: view

Orthologs for PABPC4 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PABPC4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PABPC4 36
  • 99.8 (n)
  • 100 (a)
PABPC4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PABPC4 36
  • 93.63 (n)
  • 98.29 (a)
PABPC4 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PABPC4 36
  • 94.42 (n)
  • 99.08 (a)
PABPC4 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm10110 37
  • 98 (a)
OneToMany
Pabpc4 36
  • 90.51 (n)
  • 97.88 (a)
Pabpc4 16
Pabpc4 37
  • 98 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia PABPC4 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PABPC4 37
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pabpc4 36
  • 90.84 (n)
  • 97.98 (a)
chicken
(Gallus gallus)
Aves PABPC4 36
  • 82.7 (n)
  • 91.75 (a)
PABPC4 37
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PABPC4 37
  • 90 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii -- 36
pabpc4 36
  • 75.64 (n)
  • 86.31 (a)
pabpc4 37
  • 86 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011092 36
  • 62.97 (n)
  • 67.7 (a)
fruit fly
(Drosophila melanogaster)
Insecta pAbp 36
  • 61.31 (n)
  • 62.38 (a)
pAbp 38
  • 59 (a)
CG4612 38
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea pab-2 38
  • 60 (a)
pab-1 38
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PES4 39
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.291 36
thale cress
(Arabidopsis thaliana)
eudicotyledons PAB5 36
  • 52.48 (n)
  • 48.99 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.130 36
Species with no ortholog for PABPC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)

Evolution for PABPC4 Gene

ENSEMBL:
Gene Tree for PABPC4 (if available)
TreeFam:
Gene Tree for PABPC4 (if available)

Paralogs for PABPC4 Gene

Pseudogenes.org Pseudogenes for PABPC4 Gene

genes like me logo Genes that share paralogs with PABPC4: view

Variants for PABPC4 Gene

Sequence variations from dbSNP and Humsavar for PABPC4 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9820 - 39,565,206(+) CCAGT(A/T)TATGC reference, missense
rs1058524 -- 39,572,571(-) TTTGG(A/G)CACCA reference, missense
rs1358330 -- 39,574,504(+) CAAAA(A/G)TCAGT intron-variant
rs1804943 -- 39,561,712(-) TTGCT(A/G)CTGCT missense, reference
rs2068473 -- 39,572,925(-) CTCTT(C/G)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PABPC4 Gene

Variant ID Type Subtype PubMed ID
nsv870829 CNV Gain 21882294
nsv7177 OTHER Inversion 18451855
nsv508160 CNV Loss 20534489
nsv829649 CNV Loss 17160897

Relevant External Links for PABPC4 Gene

HapMap Linkage Disequilibrium report
PABPC4

Disorders for PABPC4 Gene

Relevant External Links for PABPC4

Genetic Association Database (GAD)
PABPC4
Human Genome Epidemiology (HuGE) Navigator
PABPC4
genes like me logo Genes that share disorders with PABPC4: view

No data available for UniProtKB/Swiss-Prot for PABPC4 Gene

Publications for PABPC4 Gene

  1. iPABP, an inducible poly(A)-binding protein detected in activated human T cells. (PMID: 8524242) Yang H. … Lindsten T. (Mol. Cell. Biol. 1995) 3 4 23
  2. Identification and structure of activated-platelet protein-1, a protein with RNA-binding domain motifs that is expressed by activated platelets. (PMID: 9030741) Houng A.K. … Reed G.L. (Eur. J. Biochem. 1997) 3 4 23
  3. Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes. (PMID: 10543404) FAcral C. … GuellaAn G. (Hum. Genet. 1999) 2 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4

Products for PABPC4 Gene

  • antibodies-online peptides for PABPC4
  • antibodies-online antibodies for PABPC4
  • antibodies-online kits for PABPC4

Sources for PABPC4 Gene

Back to Top

Content