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PABPC4 Gene

protein-coding GIFtS: 65

GC01M039799

poly(A) binding protein, cytoplasmic 4 (inducible form)
(Previous names: poly(A)-binding protein, cytoplasmic 4 (inducible form) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
APP-1 ^¹, ², ³
APP1 ^², ³, ⁵
FLJ43938 ^²
IPABP ^⁵
OTTHUMP00000010668 ^²
PABP4 ^², ³, ⁵
iPABP ^¹, ², ³

Descriptions
Activated-platelet protein 1 ^³
Inducible poly(A)-binding protein ^², ³
PABP 4 ^³
Poly(A)-binding protein 4 ^³
poly A binding protein, cytoplasmic 4 ^²
poly(A) binding protein, cytoplasmic 4 (inducible form) ^²
poly(A)-binding protein, cytoplasmic 4 (inducible form) ^¹

External Ids
HGNC: 8557¹
Entrez Gene: 8761²
UniProtKB: Q13310³
Ensembl: ENSG00000090621⁷

Search outside databases for aliases for PABPC4 gene

Previous GC identifers: GC01M039944 GC01M039030 GC01M039490 GC01M039439 GC01M039422 GC01M039695

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for PABPC4:

Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most

eukaryotic mRNAs. PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell

mRNA encoding a protein. Activation of T cells increased PABPC4 mRNA levels in T cells

approximately 5-fold. PABPC4 contains 4 RNA-binding domains and proline-rich C terminus. PABPC4 is

localized primarily to the cytoplasm. It is suggested that PABPC4 might be necessary for

regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as

an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets.

PABPC4 may also be involved in the regulation of protein translation in platelets and

megakaryocytes or may participate in the binding or stabilization of polyadenylates in platelet

dense granules. Alternatively spliced transcript variants encoding different isoforms have been

found for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: PABP4_HUMAN, Q13310

Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of

mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By

similarity)

Gene Wiki entry for PABPC4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PABPC4 gene

Entrez Gene cytogenetic band: 1p32-p36 Ensembl cytogenetic band: 1p34.2 HGNC cytogenetic band: 1p34.2

PABPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M039799: (about GC identifiers)

Start:	39,799,075 bp from pter
End:	39,815,049 bp from pter
Size:	15,975 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PABP4_HUMAN, Q13310 (See protein sequence)

Recommended Name: Polyadenylate-binding protein 4

Size: 644 amino acids; 70783 Da

Subunit: Interacts with NFX1

Subcellular location: Cytoplasm

Secondary accessions: B1ANQ8 Q6P0N3

Alternative splicing: 2 isoforms: Q13310-1 Q13310-2

Post-translational modifications:

Arg-518 is dimethylated, probably to asymmetric dimethylarginine¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001129125.1 NP_001129126.1 NP_003810.1

ENSEMBL proteins:

ENSP00000361953 ENSP00000361949 ENSP00000361947 ENSP00000361948

Human Recombinant Proteins

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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PABPC4)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	8524242

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Antibodies for PABPC4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PABPC4
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	Antibodies from Abcam (PABPC4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (PABPC4)
	Novus Biologicals Antibodies for PABPC4

Assays for PABPC4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q13310

ProtoNet protein and cluster: Q13310

2 Blocks protein families:

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB002004 Polyadenylate-binding protein/HECT-associated

UniProtKB/Swiss-Prot: PABP4_HUMAN, Q13310

Similarity: Belongs to the polyadenylate-binding protein type-1 family

Similarity: Contains 1 PABC domain

Similarity: Contains 4 RRM (RNA recognition motif) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PABPC4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PABPC4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003819

Applied Biosystems Silencer® siRNAs for PABPC4

Sigma-Aldrich siRNA for PABPC4

Sigma-Aldrich shRNA for PABPC4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PABPC4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001135653
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001135653
untagged cDNA clones in CMV expression vector (see all 3): NM_001135653

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001135653

UniProtKB/Swiss-Prot: PABP4_HUMAN, Q13310

Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of

mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By

poly (A) binding nuclear protein,cytoplasmic 4,inducible,detected in activated human T cells and

activated platelets,PABPC1 homolog

5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003723	RNA binding	IEA	--
GO:0005515	protein binding	IPI	11369516 15231747 17353931
GO:0008143	poly(A) binding	IDA	8524242
GO:0008266	poly(U) binding	IDA	8524242

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for PABPC4 (Your Favorite Gene powered by Ingenuity)

Cellular Effects of Sildenafil (Viagra)

GeneDecks PABPC4 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for PABPC4

5/17 Interacting proteins for PABPC4 (ENSP00000361949³ Q13310^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ARF6	P62330¹	STRING (score=.704) EBI-372844, EBI-638181
YWHAZ	P63104¹^,²	EBI-372844, EBI-347088 MINT-3297322 EBI-372844, EBI-347088 MINT-3297322
HNF4A	P41235¹	EBI-372844, EBI-1049011
PHLDA1	Q8WV24¹	EBI-372844, EBI-738731
PINX1	Q96BK5¹	EBI-372844, EBI-721782

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006396	RNA processing	TAS	8524242
GO:0006401	RNA catabolic process	TAS	8524242
GO:0006412	translation	TAS	8524242
GO:0007596	blood coagulation	TAS	9030741

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PABPC4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PABPC4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PABPC4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003819

Sigma-Aldrich siRNA for PABPC4

Sigma-Aldrich shRNA for PABPC4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001135653 NM_001135654 NM_003819

REFSEQ mRNAs for PABPC4 gene (3 alternative transcripts):

NM_001135653.1 NM_001135654.1 NM_003819.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001135653 NM_001135654 NM_003819

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001135653
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001135653
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001135653

Additional cDNA sequence:

AB208962.1 AK222917.1 BC029969.1 BC065540.1 BC071591.1 BC094755.1 BC106908.1 BC118568.1

D12799.1 U33818.1 U75686.1

21 DOTS entries:

DT.100793433 DT.452920 DT.95165214 DT.92452279 DT.121422045 DT.95092742 DT.87079355 DT.92452278

DT.91937758 DT.100793435 DT.121422017 DT.92452282 DT.121422044 DT.99965099 DT.100725447 DT.121422006

DT.121061885 DT.87046059 DT.100793434 DT.100793436 DT.97855439

24/533 AceView cDNA sequences (see all 533 ):

AA194566 BM773073 BQ422891 AW778734 BQ681178 AA486221 AA399466 AI290918

AL702415 BE894365 BU165738 BI858827 BQ683329 AK125926 BX363405 BG315215

BQ064750 BP368719 R94184 BU501748 BG761844 AA675896 BG768456 BQ433743

highest scoring ESTs for PABPC4:

U75686 AA375867 AI126722 AL135636 AL559789 AW139446 AW249202 BE272151 BE379299 BE386964

Unigene Cluster for PABPC4:

Poly(A) binding protein, cytoplasmic 4 (inducible form)

Hs.169900 [show with all ESTs]

Unigene Representative Sequence: NM_001135653

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for PABPC4 (see all 15 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	·	10c	^	11a	·	11b	^	12a	·	12b	·	12c	·
SP1:															-		-						-				-																								-
SP2:															-		-						-				-
SP3:															-		-						-				-
SP4:																																													-
SP5:																																													-

ExUns:	12d	·	12e	^	13a	·	13b	^	14a	·	14b	^	15a	·	15b	^	16	^	17	^	18a	·	18b
SP1:	-		-		-						-
SP2:	-		-		-						-
SP3:	-		-		-		-				-
SP4:
SP5:	-		-		-		-

About this scheme

ECgene alternative splicing isoforms for PABPC4

4 Ensembl transcripts including schematic representations:

ENST00000372862 ENST00000372858 ENST00000372856 ENST00000372857

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PABPC4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PABPC4

¹ / ² / ³

3 probe-sets matching PABPC4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40506_s_at²^{, 3}	U95-A	3	1.00	0.80	1.00	1.00	U75686	1.00	0.90	0.95	1
201064_s_at²^{, 3}	U133-A	2	1.00	0.77	--	--	NM_003819	0.60	1.00	0.82	1
201064_s_at²	U133Plus2	2	1.00	0.77	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCAAGAAAGA

SOURCE GeneReport for Unigene cluster: Hs.169900
Expression variation in blood from EXPOLDB for PABPC4
UniProtKB/Swiss-Prot: PABP4_HUMAN, Q13310
Tissue specificity: Expressed at low levels in resting normal T cells; following T-cell activation,
however, mRNA levels are rapidly up-regulated

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PABPC4 gene from 5/14 species (see all 14 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PABPC4¹	--	poly(A) binding protein, cytoplasmic 4 (inducible form)	94.46(n) 99.22(a)	482464 XM_852327.1 XP_857420.1
chimpanzee (Pan troglodytes)	PABPC4¹	--	poly(A) binding protein, cytoplasmic 4 (inducible form)	99.79(n) 100(a)	456782 XM_001170937.1 XP_001170937.1
cow (Bos taurus)	PABPC4¹	--	poly(A) binding protein, cytoplasmic 4 (inducible form)	94(n) 99.07(a)	534576 XM_875610.2 XP_880703.1
rat (Rattus norvegicus)	Pabpc4¹	--	poly A binding protein, cytoplasmic 4	90.76(n) 98.11(a)	298510 XM_216517.4 XP_216517.3
mouse (Mus musculus)	Pabpc4^{1, 5}	4⁵	poly(A) binding protein, cytoplasmic 4⁵ poly A binding protein, cytoplasmic 4¹	90.42(n)¹ 97.98(a)¹	230721¹ NM_130881.2¹ NP_570951.2¹ AA068153⁵ AK016732⁵ (see all 17)

About this table Species with no ortholog for PABPC4

ENSEMBL Gene Tree for PABPC4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for PABPC4 gene

PABPC1L² PABPC3² PABPC1L2B² PABPCP5² PABPC5² PABPCP2² PABPC1L2A²

Pseudogenes

2 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/73 NCBI SNPs in PABPC4 are shown (see all 73 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 44)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs3768319^1,2	C,F,H	39798630(+)	`TTGCAG/TAATCT`	1	--	ng5¹		5	EA EU WA	1664
	rs9820^1,2	C,F,H	39803465(-)	`CCAGTA/TTATGC`	3	Y/F	mis¹ ese³		11	NA EA MN EU WA	1192
--	rs17855984^1,2	H	39810698(+)	`AAAGTG/ACCTTG`	3	V/A	mis¹ ese³		4	EU EA WA	420
	rs12127094^1,2	C,F,H	39803410(+)	`TGGAAC/TTGATT`	3	Q/Q	syn¹ ese³		5	NA EU EA WA	492
	rs2242500^1,2	A,C,F,H,O	39810489(+)	`TGGGTA/GTGGCC`	1	--	int¹		8	EA NA EU WA	2000
	rs3768320^1,2	A,C,F,H	39804826(+)	`TGTCAC/TTGTTT`	1	--	int¹		8	EA EU WA NA	2042
	rs2068473^1,2	C,F,H,O	39811184(-)	`CTCTTC/GTAAGT`	1	--	int¹		9	NA EU EA WA	738
	rs12028034^1,2	A,C,F,H	39812294(+)	`CCTCAG/AGACAA`	1	--	int¹		11	EU EA WA NA	968
	rs6680838^1,2	A,C,F,H	39813222(+)	`CATTCC/GTTCTC`	1	--	int¹		11	EU EA WA NA	980
--	rs11206343^1,2	A,C,F,H	39806238(+)	`tcggcC/Tggacg`	1	--	int¹		4	EU EA WA	418

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HapMap Linkage Disequilibrium images for PABPC4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 603407

1 PharmGKB disease relationship for PABPC4 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12730115

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/21 PubMed articles for PABPC4 gene (see all 21 ):

Identification and structure of activated-platelet protein-1, a protein with RNA-binding domain motifs that is expressed by activated platelets. (PubMed id 9030741)^{1, 3, 4} Houng A.K.... Reed G.L. (1997)
iPABP, an inducible poly(A)-binding protein detected in activated human T cells. (PubMed id 8524242)^{1, 3, 4} Yang H.... Lindsten T. (1995)
Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes. (PubMed id 10543404)^{1, 2, 3} Feral C....Guellaen G. (1999)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{3, 4} Rush J.... Comb M.J. (2005)
Identifying and quantifying in vivo methylation sites by heavy methyl SILAC. (PubMed id 15782174)^{3, 4} Ong S.E.... Mann M. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)⁴ Dephoure N.... Gygi S.P. (2008)
NFX1-123 and poly(A) binding proteins synergistically augment activation of telomerase in human papillomavirus type 16 E6-expressing cells. (PubMed id 17267499)⁴ Katzenellenbogen R.A....Galloway D.A. (2007)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)³ Ewing R.M....Figeys D. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)⁴ Gregory S.G.... Bentley D.R. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 8761	HGNC: 8557	AceView: PABPC4	Ensembl:ENSG00000090621	euGenes: HUgn8761
ECgene: PABPC4	H-InvDB: PABPC4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for PABPC4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PABPC4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PABPC4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PABPC4		Antibodies for PABPC4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PABPC4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PABPC4 Gene at Home site.
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PABPC4 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for PABPC4

Summaries
for PABPC4

Genomic Location
for PABPC4

Proteins
for PABPC4

Protein Domains/
Families
for PABPC4

Gene Function
for PABPC4

Pathways & Interactions
for PABPC4

Drugs & Compounds
for PABPC4

Transcripts
for PABPC4

Expression
for PABPC4

Orthologs
for PABPC4

Paralogs
for PABPC4

SNPs/Variants
for PABPC4

Disorders & Mutations
for PABPC4

Medical News
for PABPC4

Publications
for PABPC4

Search for PABPC4

Genome Databases showing PABPC4

Other Databases showing PABPC4

Specialized Databases showing PABPC4

Licensable Technologies
for PABPC4

Services
for PABPC4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PABPC4 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor PABPC4

Summariesfor PABPC4

Genomic Locationfor PABPC4

Proteinsfor PABPC4

Protein Domains/Familiesfor PABPC4

Gene Functionfor PABPC4

Pathways & Interactionsfor PABPC4

Drugs & Compoundsfor PABPC4

Transcriptsfor PABPC4

Expression for PABPC4

Orthologsfor PABPC4

Paralogsfor PABPC4

SNPs/Variantsfor PABPC4

Disorders & Mutationsfor PABPC4

Medical Newsfor PABPC4

Publicationsfor PABPC4

Search for PABPC4

Genome Databases showing PABPC4

Other Databases showing PABPC4

Specialized Databases showing PABPC4

Licensable Technologiesfor PABPC4

Servicesfor PABPC4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PABPC4

Summaries
for PABPC4

Genomic Location
for PABPC4

Proteins
for PABPC4

Protein Domains/
Families
for PABPC4

Gene Function
for PABPC4

Pathways & Interactions
for PABPC4

Drugs & Compounds
for PABPC4

Transcripts
for PABPC4

Expression
for PABPC4

Orthologs
for PABPC4

Paralogs
for PABPC4

SNPs/Variants
for PABPC4

Disorders & Mutations
for PABPC4

Medical News
for PABPC4

Publications
for PABPC4

Licensable Technologies
for PABPC4

Services
for PABPC4