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PABPC4 Gene

protein-coding   GIFtS: 65
GCID: GC01M040026

Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form)

(Previous names: poly(A)-binding protein, cytoplasmic 4 (inducible form))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Poly(A) Binding Protein, Cytoplasmic 4 (Inducible Form)1 2     APP-12 3
APP12 3 5     PABP-42 3
PABP42 3 5     iPABP2 3
Activated-Platelet Protein 12 3     Poly(A)-Binding Protein, Cytoplasmic 4 (Inducible Form)1
Inducible Poly(A)-Binding Protein2 3     Polyadenylate-Binding Protein 42
Poly(A)-Binding Protein 42 3     IPABP5

External Ids:    HGNC: 85571   Entrez Gene: 87612   Ensembl: ENSG000000906217   OMIM: 6034075   UniProtKB: Q133103   

Export aliases for PABPC4 gene to outside databases

Previous GC identifers: GC01M039944 GC01M039030 GC01M039490 GC01M039439 GC01M039422 GC01M039695 GC01M039799 GC01M038145


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PABPC4 Gene:
Poly(A)-binding proteins (PABPs) bind to the poly(A) tail present at the 3-prime ends of most eukaryotic mRNAs.
PABPC4 or IPABP (inducible PABP) was isolated as an activation-induced T-cell mRNA encoding a protein. Activation
of T cells increased PABPC4 mRNA levels in T cells approximately 5-fold. PABPC4 contains 4 RNA-binding domains
and proline-rich C terminus. PABPC4 is localized primarily to the cytoplasm. It is suggested that PABPC4 might be
necessary for regulation of stability of labile mRNA species in activated T cells. PABPC4 was also identified as
an antigen, APP1 (activated-platelet protein-1), expressed on thrombin-activated rabbit platelets. PABPC4 may
also be involved in the regulation of protein translation in platelets and megakaryocytes or may participate in
the binding or stabilization of polyadenylates in platelet dense granules. Alternatively spliced transcript
variants encoding different isoforms have been found for this gene. (provided by RefSeq, Oct 2008)

GeneCards Summary for PABPC4 Gene:
PABPC4 (poly(A) binding protein, cytoplasmic 4 (inducible form)) is a protein-coding gene. GO annotations related to this gene include poly(U) RNA binding and nucleotide binding. An important paralog of this gene is PABPC1L.

UniProtKB/Swiss-Prot: PABP4_HUMAN, Q13310
Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism.
Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity)

Gene Wiki entry for PABPC4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the PABPC4 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for PABPC4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PABPC4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.3   HGNC cytogenetic band: 1p34.2

PABPC4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PABPC4 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M040026:  view genomic region     (about GC identifiers)

Start:
40,026,485 bp from pter      End:
40,042,521 bp from pter
Size:
16,037 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PABP4_HUMAN, Q13310 (See protein sequence)
Recommended Name: Polyadenylate-binding protein 4  
Size: 644 amino acids; 70783 Da
Subunit: Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with NFX1
Secondary accessions: B1ANQ8 Q4VC03 Q6P0N3
Alternative splicing: 3 isoforms:  Q13310-1   Q13310-2   Q13310-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PABPC4: NX_Q13310

Explore proteomics data for PABPC4 at MOPED

Post-translational modifications: 

  • Arg-518 is dimethylated, probably to asymmetric dimethylarginine1
  • Ubiquitination2 at Lys78, Lys108, Lys113, Lys129, Lys157, Lys188, Lys196, Lys216, Lys299, Lys312,
                                 Lys333, Lys348, Lys361, Lys375
  • Modification sites at PhosphoSitePlus

  • See PABPC4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001129125.1  NP_001129126.1  NP_003810.1  

    ENSEMBL proteins: 
     ENSP00000408559   ENSP00000361953   ENSP00000361949   ENSP00000361948   ENSP00000361947  
     ENSP00000436407   ENSP00000398267   ENSP00000436566   ENSP00000436391   ENSP00000431383  
     ENSP00000406675   ENSP00000436698  

    PABPC4 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR002004 PABP_HYD
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom
     IPR006515 PABP_1234

    Graphical View of Domain Structure for InterPro Entry Q13310

    ProtoNet protein and cluster: Q13310

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB002004 Polyadenylate-binding protein/HECT-associated


    UniProtKB/Swiss-Prot: PABP4_HUMAN, Q13310
    Similarity: Belongs to the polyadenylate-binding protein type-1 family
    Similarity: Contains 1 PABC domain
    Similarity: Contains 4 RRM (RNA recognition motif) domains


    Find genes that share domains with PABPC4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PABP4_HUMAN, Q13310
    Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism.
    Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity)

         Genatlas biochemistry entry for PABPC4:
    poly (A) binding nuclear protein,cytoplasmic 4,inducible,detected in activated human T cells and activated
    platelets,PABPC1 homolog

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI11369516
    GO:0008143poly(A) binding IDA8524242
         
    Find genes that share ontologies with PABPC4           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for PABPC4:
     Decreased viability after Chla  Increased gamma-H2AX phosphory 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PABPC4

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    miRTarBase miRNAs that target PABPC4:
    hsa-mir-186-5p (MIRT044975), hsa-mir-192-5p (MIRT026691), hsa-mir-124-3p (MIRT022926), hsa-mir-16-5p (MIRT031882), hsa-mir-98-5p (MIRT027746), hsa-mir-215-5p (MIRT024565), hsa-mir-125b-5p (MIRT046051), hsa-mir-615-3p (MIRT039627)

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    8 qRT-PCR Assays for microRNAs that regulate PABPC4:
    hsa-miR-3671 hsa-miR-3140-3p hsa-miR-499-3p hsa-miR-3662 hsa-miR-3119 hsa-miR-215 hsa-miR-548aa hsa-miR-192
    SwitchGear 3'UTR luciferase reporter plasmidPABPC4 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PABP4_HUMAN, Q13310: Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0010494cytoplasmic stress granule IDA--
    GO:0030529ribonucleoprotein complex IDA17289661

    Find genes that share ontologies with PABPC4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PABPC4 About    
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    RNA degradation0.48
    2RNA transport
    RNA transport
    3mRNA surveillance pathway
    mRNA surveillance pathway


    Find genes that share SuperPaths with PABPC4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Kegg Pathways  (Kegg details for PABPC4):
        RNA transport
    mRNA surveillance pathway
    RNA degradation

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PABPC4
    Interactions:

        GeneGlobe Interaction Network for PABPC4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PABPC4 (Q133101, 2, 3 ENSP000003619494) via UniProtKB, MINT, STRING, and/or I2D (see all 169)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3MINT-62105 I2D: score=2 
    PHLDA1Q8WV241, 3, ENSP000002666714EBI-372844,EBI-738731 I2D: score=2 STRING: ENSP00000266671
    YWHAZP631042, 3, ENSP000003095034MINT-3297322 I2D: score=3 STRING: ENSP00000309503
    XRN1Q8IZH23, ENSP000002649514I2D: score=3 STRING: ENSP00000264951
    PPM1BO756883, ENSP000002824124I2D: score=2 STRING: ENSP00000282412
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006396RNA processing TAS8524242
    GO:0006401RNA catabolic process TAS8524242
    GO:0006412translation TAS8524242
    GO:0007596blood coagulation TAS9030741

    Find genes that share ontologies with PABPC4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PABPC4 (PABP4)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PABPC4 gene (3 alternative transcripts): 
    NM_001135653.1  NM_001135654.1  NM_003819.3  

    Unigene Cluster for PABPC4:

    Poly(A) binding protein, cytoplasmic 4 (inducible form)
    Hs.169900  [show with all ESTs]
    Unigene Representative Sequence: NM_001135653
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000482028 ENST00000492468 ENST00000437136 ENST00000468476 ENST00000372862
    ENST00000372858 ENST00000372857(uc001cdl.2 uc010oiv.1) ENST00000372856(uc001cdm.2)
    ENST00000530186 ENST00000421687 ENST00000484555 ENST00000525045 ENST00000527718
    ENST00000477556 ENST00000461578 ENST00000483770 ENST00000525669 ENST00000470443

    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate PABPC4:
    hsa-miR-3671 hsa-miR-3140-3p hsa-miR-499-3p hsa-miR-3662 hsa-miR-3119 hsa-miR-215 hsa-miR-548aa hsa-miR-192
    SwitchGear 3'UTR luciferase reporter plasmidPABPC4 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB208962.1 AK222917.1 BC029969.1 BC065540.1 BC071591.1 BC094755.1 BC106908.1 BC118568.1 
    D12799.1 U33818.1 U75686.1 

    21 DOTS entries:

    DT.100793433  DT.452920  DT.95165214  DT.92452279  DT.121422045  DT.95092742  DT.87079355  DT.92452278 
    DT.91937758  DT.100793435  DT.121422017  DT.92452282  DT.121422044  DT.99965099  DT.100725447  DT.121422006 
    DT.121061885  DT.87046059  DT.100793434  DT.100793436  DT.97855439 

    Selected AceView cDNA sequences (see all 533):

    BI858827 AK091110 BI257297 BQ216472 BE872328 BQ433743 BU186472 AA836484 
    BX363406 BQ679082 R94184 AI887575 AA715804 BQ683267 BQ064750 BQ439065 
    BQ434838 T32143 BC065540 BQ683329 BU501748 T17055 BG761844 AW778734 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PABPC4 (see all 15)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c ·
    SP1:                                            -     -                 -           -                                                                       -   
    SP2:                                            -     -                 -           -                                                                           
    SP3:                                            -     -                 -           -                                                                           
    SP4:                                                                                                                                      -                     
    SP5:                                                                                                                                      -                     

    ExUns: 12d · 12e ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18a · 18b
    SP1:  -     -     -                 -                                       
    SP2:  -     -     -                 -                                       
    SP3:  -     -     -     -           -                                       
    SP4:                                                                        
    SP5:  -     -     -     -                                                   


    ECgene alternative splicing isoforms for PABPC4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PABPC4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCAAGAAAGA
    PABPC4 Expression
    About this image


    PABPC4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    PABPC4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PABPC4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.169900

    UniProtKB/Swiss-Prot: PABP4_HUMAN, Q13310
    Tissue specificity: Expressed at low levels in resting normal T cells; following T-cell activation, however, mRNA
    levels are rapidly up-regulated

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PABPC4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PABPC4 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pabpc41 , 5 poly(A) binding protein, cytoplasmic 41, 5 90.51(n)1
    97.88(a)1
      4 (57.42 cM)5
    2307211  NM_130881.21  NP_570951.21 
     1232623515 
    chicken
    (Gallus gallus)
    Aves PABPC41 poly(A) binding protein, cytoplasmic 4 (inducible form) 82.7(n)
    91.75(a)
      419674  XM_004947871.1  XP_004947928.1 
    lizard
    (Anolis carolinensis)
    Reptilia PABPC46
    poly(A) binding protein, cytoplasmic 4 (inducible ...
    90(a)
    1 ↔ 1
    GL343481.1(234483-244198)
    zebrafish
    (Danio rerio)
    Actinopterygii BC053126.12   -- 78.65(n)   321035  BC053126.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pAbp1 , 3 RNA binding3
    polyA-binding protein1
    59(a)
    (best of 2)3
    61.31(n)1
    62.38(a)1
      370701  NM_166264.31  NP_725749.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PAB51 PAB5 52.48(n)
    48.99(a)
      843507  NM_105835.2  NP_177322.2 
    rice
    (Oryza sativa)
    Liliopsida AK067210.12   -- 74.84(n)    AK067210.1 


    ENSEMBL Gene Tree for PABPC4 (if available)
    TreeFam Gene Tree for PABPC4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PABPC4 gene
    PABPC1L2  PABPC52  ELAVL12  PABPC4L2  ELAVL42  RBMS12  ELAVL32  RBMS32  
    PABPC32  ELAVL22  RBMS22  PABPC12  
    Selected SIMAP similar genes for PABPC4 using alignment to 12 protein entries:     PABP4_HUMAN (see all proteins) (see all similar genes):
    PABPC1L2A    PABPC1L2B    PABPC4L    PABPC1L    PABPC5    PABPC1
    RLIM    PABPC3    RBMY1A1    ELAVL2    BOLL    RBM7
    RBMY1C    RBMY1D    RBMY1E    RBMY1J    HNRNPA1    SF3B4

    Find genes that share paralogs with PABPC4           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for PABPC4
    PGOHUM00000239817 PGOHUM00000244749 PGOHUM00000243725 PGOHUM00000258297


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for PABPC4 (see all 338)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs127557431,2
    C,F,H--40027464(+) CCTGCG/AAGAAA 3 -- int122Minor allele frequency- A:0.06NS EA NA EU 3484
    rs1849127831,2
    C--40027503(+) GCTACG/TCCACC 3 -- int10--------
    rs1477134501,2
    --40027563(+) GATCCC/GTAGGC 3 -- int10--------
    rs1425576821,2
    --40027630(+) CATGAC/TGAGAG 3 -- int10--------
    rs2017823501,2
    --40027727(+) GCAGGG/TTCTGA 3 -- int10--------
    rs1897167051,2
    C--40027888(+) GAGGAC/TAGTTA 3 -- int10--------
    rs2012126051,2
    --40027890(+) GGATAA/GTTAAT 3 -- int10--------
    rs1823442511,2
    C--40027905(+) AAACAA/GATCAA 3 -- int10--------
    rs2019973831,2
    --40028017(+) TCCTGA/GGGGGG 6 P syn10--------
    rs2010901881,2
    --40028047(+) GCAGTC/GAGTGG 6 L syn10--------

    HapMap Linkage Disequilibrium report for PABPC4 (40026485 - 40042521 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for PABPC4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508160CNV Loss20534489
    nsv829649CNV Loss17160897
    nsv870829CNV Gain21882294
    nsv7177OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PABPC4
    DNA2.0 Custom Variant and Variant Library Synthesis for PABPC4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603407    OMIM disorders: --


    Find genes that share disorders with PABPC4           About GenesLikeMe

    Genetic Association Database (GAD): PABPC4
    Human Genome Epidemiology (HuGE) Navigator: PABPC4 (1 document)

    Export disorders for PABPC4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PABPC4 gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with PABPC4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and structure of activated-platelet protein-1, a protein with RNA-binding domain motifs that is expressed by activated platelets. (PubMed id 9030741)1, 2, 9 Houng A.K.... Reed G.L. (Eur. J. Biochem. 1997)
    2. iPABP, an inducible poly(A)-binding protein detected in activated human T cells. (PubMed id 8524242)1, 2, 9 Yang H.... Lindsten T. (Mol. Cell. Biol. 1995)
    3. Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes. (PubMed id 10543404)1, 3, 9 FAcral C....GuellaAn G. (Hum. Genet. 1999)
    4. Biological, clinical and population relevance of 95 loci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (Nature 2010)
    5. Molecular composition of IMP1 ribonucleoprotein granules. (PubMed id 17289661)1, 2 Joeson L.... Nielsen F.C. (Mol. Cell. Proteomics 2007)
    6. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A Proteomics Strategy for the Identification of FAT10-Modified Sites by Mass Spectrometry. (PubMed id 23862649)1 Leng L....Wang J. (J. Proteome Res. 2014)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8761 HGNC: 8557 AceView: PABPC4 Ensembl:ENSG00000090621 euGenes: HUgn8761
    ECgene: PABPC4 Kegg: 8761 H-InvDB: PABPC4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for PABPC4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for PABPC4 gene:
    Search GeneIP for patents involving PABPC4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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