PABPC3 Gene
protein-coding GIFtS: 54
GCID: GC13P025670
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poly(A) binding protein, cytoplasmic 3(Previous names: poly(A)-binding protein, cytoplasmic 3 )
(Previous symbol: PABPL3)
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Aliases
for PABPC3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Poly(A) Binding Protein, Cytoplasmic 31 2 | | Poly(A)-Binding Protein-Like 32 | | PABP31 2 3 5 | | Polyadenylate-Binding Protein 32 | | PABPL31 2 3 5 | | Testis PABP2 | | TPABP1 | | Testis-Specific Poly(A)-Binding Protein (PABP)2 | | Poly(A)-Binding Protein 32 3 | | Testis-Specific Poly(A)-Binding Protein 32 | | PABP-32 3 | | Testis-Specific Poly(A)-Binding Protein3 | | Poly(A)-Binding Protein, Cytoplasmic 31 | | |
Export aliases for PABPC3 gene to outside databasesPrevious GC identifers: GC13P023650 GC13P019650 GC13P024600 GC13P023468 GC13P024568 GC13P006483 |
Summaries
for PABPC3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PABPC3:
Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins(PABP). See PABPC1 (MIM 604679) for background information.(supplied by OMIM, Jul 2002)
UniProtKB/Swiss-Prot: PABP3_HUMAN, Q9H361Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Bindspoly(A) with a slightly lower affinity as compared to PABPC1
Gene Wiki entry for PABPC3
|
Genomic Views
for PABPC3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PABPC3 gene promoter:
TBP Elk-1 p53 CUTL1 AP-4 POU3F2 GATA-2 E47 AREB6 ARP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PABPC3
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PABPC3 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q12-q13 Ensembl cytogenetic band: 13q12.13 HGNC cytogenetic band: 13q12-q13PABPC3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P025670: view genomic region
(about GC identifiers)
Start:
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25,670,006 bp from pter |
End:
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25,673,392 bp from pter |
Size:
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3,387 bases |
Orientation:
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plus strand |
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Proteins
for PABPC3 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PABP3_HUMAN, Q9H361 (See
protein sequence)Recommended Name: Polyadenylate-binding protein 3 Size: 631 amino acids; 70031 Da
Subcellular location: Cytoplasm (By similarity)
2 PDB 3D structures from  and Proteopedia  for PABPC3:2D9P (3D)
4IVE (3D)
Secondary accessions: Q8NHV0 Q9H086Explore the universe of human proteins at neXtProt for PABPC3: NX_Q9H361
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H361
PABPC3 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_112241.2
ENSEMBL proteins: ENSP00000455059 ENSP00000455333 ENSP00000281589
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table
PABPC3 for ontologies About GeneDecksing
PABPC3 Antibody Products:
Assay Products for PABPC3: |
Protein
Domains /
Families
for PABPC3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PABPC3 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9H361ProtoNet protein and cluster: Q9H361 2 Blocks protein families: IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB002004 Polyadenylate-binding protein/HECT-associated
UniProtKB/Swiss-Prot: PABP3_HUMAN, Q9H361Similarity: Belongs to the polyadenylate-binding protein type-1 familySimilarity: Contains 1 PABC domainSimilarity: Contains 4 RRM (RNA recognition motif) domains |
Function
for PABPC3 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PABP3_HUMAN, Q9H361Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Bindspoly(A) with a slightly lower affinity as compared to PABPC1 Genatlas biochemistry entry for PABPC3:poly(A) binding protein,cytoplasmic 3
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PABPC3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PABPC3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for PABPC3 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PABPC3 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PABPC3 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
PABPC3 for ontologies About GeneDecksing
|
Pathways & Interactions
for PABPC3 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | mRNA surveillance pathway | | | 2 | RNA transport | | | 3 | Deadenylation-dependent mRNA decay | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Kegg Pathways (Kegg details for PABPC3):
PABPC3 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PABPC3
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/122 Interacting proteins for PABPC3 (Q9H3612, 3 ENSP000002815894) via UniProtKB, MINT, STRING, and/or I2D (see all 122)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
PABPC3 for ontologies About GeneDecksing
|
Drugs & Compounds
for PABPC3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for PABPC3
Search CenterWatch for drugs/clinical trials and news about PABPC3 / PABP3
|
Transcripts
for PABPC3 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PABPC3 gene: NM_030979.2 Unigene Cluster for PABPC3: Poly(A) binding protein, cytoplasmic 3 Hs.458280 [show with all ESTs]Unigene Representative Sequence: BC0456083 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000569397 ENST00000562709(uc001upy.3) ENST00000281589
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PABPC3
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PABPC3
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: PABPC3 (NM_030979) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PABPC3 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PABPC3 |
Additional cDNA sequence: AF132026.1 AK313336.1 AL136900.1 BC027617.2 BC045608.1 24/31 DOTS entries (see all 31): DT.91661782 DT.95267608 DT.100700595 DT.92470838 DT.91954612 DT.92470896 DT.100700601 DT.91870787 DT.121466365 DT.92470903 DT.95267689 DT.100700590 DT.100700596 DT.120762244 DT.121466486 DT.91801712 DT.92359426 DT.95267669 DT.95267672 DT.100060609 DT.120762238 DT.120762240 DT.121466401 DT.121466409 24/32 AceView cDNA sequences (see all 32): CD243801 AL040749 NM_030979 BC027617 AL136900 AA954581 AL046737 CD358574 BG717008 AF132026 BI825788 BG718483 BI460001 AI025825 BI464014 BU567424 AL040750 CD358948 AL040794 BG723981 CD358457 AA382298 BF349176 BE091857
GeneLoc Exon Structure
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Expression
for PABPC3 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PABPC3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTGTTGGAGA
About this image
See PABPC3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PABPC3
SOURCE GeneReport for Unigene cluster: Hs.458280
UniProtKB/Swiss-Prot: PABP3_HUMAN, Q9H361Tissue specificity: Testis specific
SABiosciences Custom PCR Arrays for PABPC3
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PABPC3
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat PABPC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PABPC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PABPC3 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PABPC3 |
Orthologs
for PABPC3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PABPC3 gene from 6/22 species (see all 22) About this table
ENSEMBL Gene Tree for PABPC3 (if available)
TreeFam Gene Tree for PABPC3 (if available) |
Paralogs
for PABPC3 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PABPC3 gene
- PABPC1L2 PABPC52 PABPC42 PABPC4L2 ELAVL12 RBMS12 ELAVL42 ELAVL32
- RBMS32 ELAVL22 PABPC1L2B2 PABPC1L2A2 PUF602 RBMS22 PABPC12
18/20 SIMAP similar genes for PABPC3 using alignment to 5 protein entries: PABP3_HUMAN (see all proteins)
(see all similar genes):PABPC1 PABPC1L2A PABPC1L2B PABPC4L PABPC4 PABPC1L
DKFZp547H118 PABPC5 RBMY1A1 RBM7 RBMX ELAVL2
SF3B4 HNRNPA1 RBMS1 TIA1 TIAL1 HNRNPD
PABPC3 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for PABPC3
PGOHUM00000240029 PGOHUM00000245501
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Genomic Variants
for PABPC3 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PABPC3 (25670006 - 25673392 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PABPC3
1 Inversion: 29491 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PABPC3 |
|
Disorders
/ Diseases
for PABPC3 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PABPC3 for disorders About GeneDecksing
OMIM gene information: 604680
OMIM disorders: --
1  disease for PABPC3: About MalaCardsmalaria
Export disorders for PABPC3 gene to outside databases
|
Publications
for PABPC3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PABPC3 gene, integrated from 9 sources (see all 16):
(articles sorted by number of sources associating them with PABPC3) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- Human testis expresses a specific poly(A)-binding protein. (PubMed id 11328870)1, 2 Feral C.... Pawlak A. (2001)
- Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes. (PubMed id 10543404)1, 3 Feral C....Guellaen G. (1999)
- Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization. (PubMed id 8432538)1, 3 Morris C.M. and Bodger M.P. (1993)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- HIV- 1 protease inhibits Cap- and poly(A)-dependent t ranslation upon eIF4GI and PABP cleavage. (PubMed id 19956697)1 CastellA^ A....Carrasco L. (2009)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
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External Searches for PABPC3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing PABPC3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PABPC3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PABPC3 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PABPC3 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PABPC3 gene:
Search GeneIP for patents involving PABPC3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PABPC3 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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variant library, vector shuttling | | | OriGene Custom Antibody Services for PABPC3 | | OriGene Custom Protein Services for PABPC3 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PABPC3 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PABPC3 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PABPC3 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PABPC3 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PABPC3 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PABPC3 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PABPC3 |
|  |  |  | | | | ThermoFisher Antibodies for PABPC3 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PABPC3 |
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