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Aliases for PABPC3 Gene

Aliases for PABPC3 Gene

  • Poly(A) Binding Protein Cytoplasmic 3 2 3 5
  • Poly(A)-Binding Protein 3 3 4
  • Testis PABP 2 3
  • PABPL3 3 4
  • PABP-3 3 4
  • PABP3 3 4
  • Testis-Specific Poly(A)-Binding Protein (PABP) 3
  • Testis-Specific Poly(A)-Binding Protein 3 3
  • Testis-Specific Poly(A)-Binding Protein 4
  • Poly(A)-Binding Protein, Cytoplasmic 3 2
  • Polyadenylate-Binding Protein 3 3
  • Poly(A)-Binding Protein-Like 3 3
  • TPABP 3

External Ids for PABPC3 Gene

Previous HGNC Symbols for PABPC3 Gene

  • PABPL3

Previous GeneCards Identifiers for PABPC3 Gene

  • GC13P023650
  • GC13P019650
  • GC13P024600
  • GC13P023468
  • GC13P024568
  • GC13P025670
  • GC13P006483

Summaries for PABPC3 Gene

Entrez Gene Summary for PABPC3 Gene

  • Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002]

GeneCards Summary for PABPC3 Gene

PABPC3 (Poly(A) Binding Protein Cytoplasmic 3) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is MIR7705.

UniProtKB/Swiss-Prot for PABPC3 Gene

  • Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.

Gene Wiki entry for PABPC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC3 Gene

Genomics for PABPC3 Gene

Regulatory Elements for PABPC3 Gene

Enhancers for PABPC3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13F025871 1 Ensembl ENCODE 6.2 +778.0 777979 4.1 MAX BCL6 RAD21 MYC PABPC3 GC13P025866 PIR50437 RN7SL741P
GH13F026048 0.4 ENCODE 5 +955.1 955102 4.3 CBX3 ZNF133 SIN3A FEZF1 GLIS2 SCRT2 REST ZFP69B SMARCA4 GLIS1 SHISA2 PABPC3 LINC00415 PIR56473
GH13F024910 1.2 FANTOM5 Ensembl ENCODE 1.3 -184.6 -184563 1.4 PKNOX1 JUN MAX BACH1 CHAMP1 ZNF316 CTBP1 STAT2 NFE2 FOS NUP58 MTMR6 PARP4 PABPC3 CENPJ PIR31198 GC13P024781
GH13F025115 1.2 FANTOM5 ENCODE 0.3 +20.9 20893 2.5 ZNF687 CEBPG DPF2 ZNF592 CTBP1 ATF4 GATA3 CEBPA TCF7L2 AMER2 LINC00463 LINC01053 PABPC3 ENSG00000279695
GH13F025113 1 ENCODE 0.3 +18.7 18695 1.5 CTCF ZNF654 PKNOX1 TRIM22 REST KLF4 RAD21 GATA3 SMARCA4 TARDBP AMER2 LINC00463 LINC01053 PABPC3 ENSG00000279695
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around PABPC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PABPC3 Gene

Chromosome:
13
Start:
25,095,868 bp from pter
End:
25,099,254 bp from pter
Size:
3,387 bases
Orientation:
Plus strand

Genomic View for PABPC3 Gene

Genes around PABPC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PABPC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PABPC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC3 Gene

Proteins for PABPC3 Gene

  • Protein details for PABPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H361-PABP3_HUMAN
    Recommended name:
    Polyadenylate-binding protein 3
    Protein Accession:
    Q9H361
    Secondary Accessions:
    • Q8NHV0
    • Q9H086

    Protein attributes for PABPC3 Gene

    Size:
    631 amino acids
    Molecular mass:
    70031 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PABPC3 Gene

neXtProt entry for PABPC3 Gene

Post-translational modifications for PABPC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PABPC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for PABPC3
  • Santa Cruz Biotechnology (SCBT) Antibodies for PABPC3

No data available for DME Specific Peptides for PABPC3 Gene

Domains & Families for PABPC3 Gene

Gene Families for PABPC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H361

UniProtKB/Swiss-Prot:

PABP3_HUMAN :
  • Contains 1 PABC domain.
  • Belongs to the polyadenylate-binding protein type-1 family.
Domain:
  • Contains 1 PABC domain.
  • Contains 4 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the polyadenylate-binding protein type-1 family.
genes like me logo Genes that share domains with PABPC3: view

Function for PABPC3 Gene

Molecular function for PABPC3 Gene

GENATLAS Biochemistry:
poly(A) binding protein,cytoplasmic 3
UniProtKB/Swiss-Prot Function:
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.

Gene Ontology (GO) - Molecular Function for PABPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IEA --
GO:0008143 poly(A) binding IDA 11328870
genes like me logo Genes that share ontologies with PABPC3: view

Phenotypes for PABPC3 Gene

GenomeRNAi human phenotypes for PABPC3:
genes like me logo Genes that share phenotypes with PABPC3: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PABPC3 Gene

Localization for PABPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PABPC3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PABPC3 Gene COMPARTMENTS Subcellular localization image for PABPC3 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for PABPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11328870
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with PABPC3: view

Pathways & Interactions for PABPC3 Gene

genes like me logo Genes that share pathways with PABPC3: view

Pathways by source for PABPC3 Gene

3 KEGG pathways for PABPC3 Gene

Gene Ontology (GO) - Biological Process for PABPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016071 mRNA metabolic process NAS 11328870
genes like me logo Genes that share ontologies with PABPC3: view

No data available for SIGNOR curated interactions for PABPC3 Gene

Transcripts for PABPC3 Gene

mRNA/cDNA for PABPC3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPC3 Gene

Poly(A) binding protein, cytoplasmic 3:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC3 Gene

No ASD Table

Relevant External Links for PABPC3 Gene

GeneLoc Exon Structure for
PABPC3
ECgene alternative splicing isoforms for
PABPC3

Expression for PABPC3 Gene

mRNA expression in normal human tissues for PABPC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PABPC3 Gene

This gene is overexpressed in Testis (x43.9).

Protein differential expression in normal tissues from HIPED for PABPC3 Gene

This gene is overexpressed in Brain (58.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PABPC3 Gene



Protein tissue co-expression partners for PABPC3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PABPC3 Gene:

PABPC3

SOURCE GeneReport for Unigene cluster for PABPC3 Gene:

Hs.458280

mRNA Expression by UniProt/SwissProt for PABPC3 Gene:

Q9H361-PABP3_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with PABPC3: view

Primer Products

Orthologs for PABPC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PABPC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PABPC3 34 35
  • 99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 92 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 84 (a)
ManyToMany
-- 35
  • 83 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Pabpc2 35
  • 75 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PABPC1 35
  • 91 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 86 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pabpc1a 34 35
  • 73.75 (n)
fruit fly
(Drosophila melanogaster)
Insecta pAbp 36
  • 54 (a)
CG4612 36
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea pab-2 36
  • 54 (a)
pab-1 36
  • 50 (a)
Species where no ortholog for PABPC3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PABPC3 Gene

ENSEMBL:
Gene Tree for PABPC3 (if available)
TreeFam:
Gene Tree for PABPC3 (if available)

Paralogs for PABPC3 Gene

(15) SIMAP similar genes for PABPC3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PABPC3 Gene

genes like me logo Genes that share paralogs with PABPC3: view

Variants for PABPC3 Gene

Sequence variations from dbSNP and Humsavar for PABPC3 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs112107735 -- 25,096,739(+) GAGAA(A/G)CTGAA intron-variant, reference, missense
rs112394373 -- 25,098,115(+) ACGAA(A/C)AGAAA intron-variant, utr-variant-3-prime
rs112901832 -- 25,097,541(+) TGCTA(C/T)CCGCC intron-variant, reference, missense
rs112907672 -- 25,096,962(+) AAAGG(A/G)GCTCA intron-variant, reference, missense
rs113301206 -- 25,097,648(+) AGACA(A/G)TGGGT intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PABPC3 Gene

Variant ID Type Subtype PubMed ID
dgv7e24 CNV loss 17666407
esv2659512 CNV deletion 23128226
esv2747161 CNV deletion 23290073
nsv1047876 CNV gain 25217958
nsv435952 OTHER inversion 17901297
nsv983566 CNV duplication 23825009

Variation tolerance for PABPC3 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.73; 89.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PABPC3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PABPC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPC3 Gene

Disorders for PABPC3 Gene

Relevant External Links for PABPC3

Genetic Association Database (GAD)
PABPC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PABPC3

No disorders were found for PABPC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PABPC3 Gene

Publications for PABPC3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  3. Human testis expresses a specific poly(A)-binding protein. (PMID: 11328870) Feral C. … Pawlak A. (Nucleic Acids Res. 2001) 3 4 64
  4. Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes. (PMID: 10543404) FAcral C. … GuellaAn G. (Hum. Genet. 1999) 2 3 64
  5. Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization. (PMID: 8432538) Morris C.M. … Bodger M.P. (Genomics 1993) 2 3 64

Products for PABPC3 Gene

Sources for PABPC3 Gene

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