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Aliases & Descriptions for PABPC3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| PABP3 1, 2, 3, 5 | | PABPL3 2, 3, 5 |
| | | Descriptions |
|---|
| PABP 3 3 | | Poly(A)-binding protein 3 3 | | Testis-specific poly(A)-binding protein 3 | | poly(A) binding protein, cytoplasmic 3 2 | | poly(A)-binding protein, cytoplasmic 3 1 | | poly(A)-binding protein-like 3 2 | | testis-specific poly(A)-binding protein (PABP) 2 | | testis-specific poly(A)-binding protein 3 2 |
|
| | Search outside databases for aliases for PABPC3 genePrevious GC identifers: GC13P023650 GC13P019650 GC13P024600 GC13P023468 |
Summaries for PABPC3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for PABPC3: Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM] UniProtKB/Swiss-Prot: PABP3_HUMAN, Q9H361Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1Gene Wiki entry for PABPC3 |
Genomic Location for PABPC3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the PABPC3 gene 
Entrez Gene cytogenetic band: 13q12-q13 Ensembl cytogenetic band: 13q12.13 HGNC cytogenetic band: 13q12-q13PABPC3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P024568:
(about GC identifiers)
Start:
|
24,568,276 bp from pter |
End:
|
24,570,705 bp from pter |
Size:
|
2,430 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000013.9 NT_024524.13
| Proteins for PABPC3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: PABP3_HUMAN, Q9H361 (See
protein sequence)Recommended Name: Polyadenylate-binding protein 3 Size: 631 amino acids; 70031 Da
Subcellular location: Cytoplasm (By similarity)
PDB structures from and Proteopedia :2D9P (3D)
 
Secondary accessions: Q8NHV0 Q9H086Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_112241.2
ENSEMBL proteins: ENSP00000281589
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
1 Gene Ontology (GO) cellular component term (links to tree view): About this table
Antibodies for PABPC3: Assays for PABPC3: | Protein
Domains/ Families for PABPC3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9H361
ProtoNet protein and cluster: Q9H361 2 Blocks protein families: IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB002004 Polyadenylate-binding protein/HECT-associated
UniProtKB/Swiss-Prot: PABP3_HUMAN, Q9H361Similarity: Belongs to the polyadenylate-binding protein type-1 familySimilarity: Contains 1 PABC domainSimilarity: Contains 4 RRM (RNA recognition motif) domains | Gene Function for PABPC3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_030979
Applied Biosystems Silencer® siRNAs for PABPC3
Sigma-Aldrich siRNA for PABPC3  Sigma-Aldrich shRNA for PABPC3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_030979                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_030979                                  untagged cDNA clone in CMV expression vector: NM_030979 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_030979
UniProtKB/Swiss-Prot: PABP3_HUMAN, Q9H361Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1Genatlas biochemistry entry for PABPC3:poly(A) binding protein,cytoplasmic 33 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for PABPC3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/234 Interacting proteins for PABPC3 (Q9H3612) via UniProtKB, MINT, and/or STRING (see all 234
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): About this table
|
Drugs & Compounds for PABPC3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for PABPC3
|
Transcripts for PABPC3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_030979
Sigma-Aldrich siRNA for PABPC3  Sigma-Aldrich shRNA for PABPC3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_030979 REFSEQ mRNAs for PABPC3 gene: NM_030979.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_030979               OriGene GFP tagged cDNA clone in CMV expression vector: NM_030979                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_030979                                  untagged cDNA clone in CMV expression vector: NM_030979  Additional cDNA sequence: AF132026.1 AK313336.1 AL136900.1 BC027617.2 BC045608.1 24/30 DOTS entries (see all 30
): DT.91661782 DT.95267608 DT.100700595 DT.92470838 DT.91954612 DT.92470896 DT.100700601 DT.91870787 DT.121466365 DT.92470903 DT.95267689 DT.100700590 DT.100700596 DT.120762244 DT.121466486 DT.91801712 DT.92359426 DT.95267669 DT.95267672 DT.100060609 DT.120762238 DT.120762240 DT.121466401 DT.121466465 24/32 AceView cDNA sequences (see all 32
):AL040749 BC027617 AA954581 AL136900 CD243801 NM_030979 BI460001 AF132026 BG717008 AL040794 BU567424 BI825788 CD358574 AL040750 BG718483 AI025825 BI464014 CD358948 AL046737 BG723981 AA382298 CD358457 BE091857 BF349176
highest scoring ESTs for PABPC3:AA954581 AF132026 AI025825 AL040750 AL040794 AL136900 BC027617 BG717008 BG718483 BG723981 Unigene Cluster for PABPC3: Poly(A) binding protein, cytoplasmic 3 Hs.458280 [show with all ESTs]Unigene Representative Sequence: BC045608
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000281589
|
Expression for PABPC3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| PABPC3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for PABPC3
1 / 2 / 3 3 probe-sets matching PABPC3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTGTTGGAGA
SOURCE GeneReport for Unigene cluster: Hs.458280 UniProtKB/Swiss-Prot: PABP3_HUMAN, Q9H361Tissue specificity: Testis specific |
Orthologs for PABPC3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PABPC3 gene from 3 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
chimpanzee (Pan troglodytes) |
PABPC31 |
-- |
poly(A) binding protein, cytoplasmic 3 |
99(n) 97.78(a) |
452494 XM_001154541.1 XP_001154541.1 |
fruit fly (Drosophila melanogaster) |
pAbp3 |
55B8--9 |
RNA binding |
54(a) (best of 2) |
-- |
worm (Caenorhabditis elegans) |
pab-23 |
X(13557928-13561043) |
RNA recognition motif. (aka RRM, RBD, or RNP domain) more |
54(a) (best of 2) |
-- |
About this table Species with no ortholog for PABPC3
ENSEMBL Gene Tree for PABPC3 | Paralogs for PABPC3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for PABPC3 gene
- PABPC1L2 PABPC52 PABPC1L2B2 PABPCP52 PABPCP22 PABPC42 PABPC1L2A2
|
SNPs/Variants for PABPC3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for PABPC3 (up to first 250kb)
|
Disorders & Mutations for PABPC3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604680
|
Medical News for PABPC3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for PABPC3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for PABPC3 gene:- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)3, 4 Wiemann S.... Poustka A. (2001)
- Human testis expresses a specific poly(A)-binding protein. (PubMed id 11328870)3, 4 Feral C.... Pawlak A. (2001)
- Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes. (PubMed id 10543404)2, 3 Feral C....Guellaen G. (1999)
- Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization. (PubMed id 8432538)2, 3 Morris C.M. and Bodger M.P. (1993)
- Emergence of young human genes after a burst of retroposition in primates. (PubMed id 16201836)3 Marques A.C.... Kaessmann H. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- The eukaryotic polypeptide chain releasing factor (eRF3/GSPT) carrying the translation termination signal to the 3'-Poly(A) tail of mRNA. Direct association of erf3/GSPT with polyadenylate-binding protein. (PubMed id 10358005)3 Hoshino S....Katada T. (1999)
|
Search for PABPC3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing PABPC3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing PABPC3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PABPC3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for PABPC3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for PABPC3:

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Incremental update: 13 Oct 2009
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