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Aliases for PABPC3 Gene

Aliases for PABPC3 Gene

  • Poly(A) Binding Protein Cytoplasmic 3 2 3
  • Poly(A) Binding Protein, Cytoplasmic 3 3 5
  • Poly(A)-Binding Protein 3 3 4
  • Testis PABP 2 3
  • PABPL3 3 4
  • PABP-3 3 4
  • PABP3 3 4
  • Testis-Specific Poly(A)-Binding Protein (PABP) 3
  • Testis-Specific Poly(A)-Binding Protein 3 3
  • Testis-Specific Poly(A)-Binding Protein 4
  • Poly(A)-Binding Protein, Cytoplasmic 3 2
  • Poly(A)-Binding Protein-Like 3 3
  • TPABP 3

External Ids for PABPC3 Gene

Previous HGNC Symbols for PABPC3 Gene

  • PABPL3

Previous GeneCards Identifiers for PABPC3 Gene

  • GC13P023650
  • GC13P019650
  • GC13P024600
  • GC13P023468
  • GC13P024568
  • GC13P025670
  • GC13P006483

Summaries for PABPC3 Gene

Entrez Gene Summary for PABPC3 Gene

  • Messenger RNA stability and translation initiation are extensively under the control of poly(A)-binding proteins (PABP). See PABPC1 (MIM 604679) for background information.[supplied by OMIM, Jul 2002]

GeneCards Summary for PABPC3 Gene

PABPC3 (Poly(A) Binding Protein Cytoplasmic 3) is a Protein Coding gene. Among its related pathways are mRNA surveillance pathway and Deadenylation-dependent mRNA decay. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC1L2A.

UniProtKB/Swiss-Prot for PABPC3 Gene

  • Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.

Gene Wiki entry for PABPC3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC3 Gene

Genomics for PABPC3 Gene

Regulatory Elements for PABPC3 Gene

Enhancers for PABPC3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PABPC3 on UCSC Golden Path with GeneCards custom track

Promoters for PABPC3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PABPC3 on UCSC Golden Path with GeneCards custom track

Genomic Location for PABPC3 Gene

Chromosome:
13
Start:
25,095,868 bp from pter
End:
25,099,254 bp from pter
Size:
3,387 bases
Orientation:
Plus strand

Genomic View for PABPC3 Gene

Genes around PABPC3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PABPC3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PABPC3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC3 Gene

Proteins for PABPC3 Gene

  • Protein details for PABPC3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H361-PABP3_HUMAN
    Recommended name:
    Polyadenylate-binding protein 3
    Protein Accession:
    Q9H361
    Secondary Accessions:
    • Q8NHV0
    • Q9H086

    Protein attributes for PABPC3 Gene

    Size:
    631 amino acids
    Molecular mass:
    70031 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for PABPC3 Gene

neXtProt entry for PABPC3 Gene

Proteomics data for PABPC3 Gene at MOPED

Post-translational modifications for PABPC3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PABPC3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for PABPC3 Gene

Domains & Families for PABPC3 Gene

Gene Families for PABPC3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H361

UniProtKB/Swiss-Prot:

PABP3_HUMAN :
  • Contains 1 PABC domain.
  • Belongs to the polyadenylate-binding protein type-1 family.
Domain:
  • Contains 1 PABC domain.
  • Contains 4 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the polyadenylate-binding protein type-1 family.
genes like me logo Genes that share domains with PABPC3: view

Function for PABPC3 Gene

Molecular function for PABPC3 Gene

GENATLAS Biochemistry:
poly(A) binding protein,cytoplasmic 3
UniProtKB/Swiss-Prot Function:
Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Binds poly(A) with a slightly lower affinity as compared to PABPC1.

Gene Ontology (GO) - Molecular Function for PABPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0008143 poly(A) binding IDA 11328870
genes like me logo Genes that share ontologies with PABPC3: view

Phenotypes for PABPC3 Gene

GenomeRNAi human phenotypes for PABPC3:
genes like me logo Genes that share phenotypes with PABPC3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PABPC3 Gene

Localization for PABPC3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PABPC3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PABPC3 Gene COMPARTMENTS Subcellular localization image for PABPC3 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for PABPC3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm NAS 11328870
genes like me logo Genes that share ontologies with PABPC3: view

Pathways & Interactions for PABPC3 Gene

genes like me logo Genes that share pathways with PABPC3: view

Pathways by source for PABPC3 Gene

3 KEGG pathways for PABPC3 Gene

Gene Ontology (GO) - Biological Process for PABPC3 Gene

None

No data available for SIGNOR curated interactions for PABPC3 Gene

Drugs & Compounds for PABPC3 Gene

No Compound Related Data Available

Transcripts for PABPC3 Gene

mRNA/cDNA for PABPC3 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPC3 Gene

Poly(A) binding protein, cytoplasmic 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC3 Gene

No ASD Table

Relevant External Links for PABPC3 Gene

GeneLoc Exon Structure for
PABPC3
ECgene alternative splicing isoforms for
PABPC3

Expression for PABPC3 Gene

mRNA expression in normal human tissues for PABPC3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PABPC3 Gene

This gene is overexpressed in Testis (x43.9).

Protein differential expression in normal tissues from HIPED for PABPC3 Gene

This gene is overexpressed in Brain (58.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PABPC3 Gene



SOURCE GeneReport for Unigene cluster for PABPC3 Gene Hs.458280

mRNA Expression by UniProt/SwissProt for PABPC3 Gene

Q9H361-PABP3_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with PABPC3: view

Protein tissue co-expression partners for PABPC3 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PABPC3 Gene

This gene was present in the common ancestor of animals.

Orthologs for PABPC3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PABPC3 35
  • 99 (n)
  • 97.78 (a)
PABPC3 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
ManyToMany
-- 36
  • 83 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Pabpc2 36
  • 75 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves PABPC1 36
  • 91 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 86 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii pabpc1a 35
  • 73.75 (n)
  • 83.87 (a)
pabpc1a 36
  • 83 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4612 37
  • 48 (a)
pAbp 37
  • 54 (a)
worm
(Caenorhabditis elegans)
Secernentea pab-1 37
  • 50 (a)
pab-2 37
  • 54 (a)
Species with no ortholog for PABPC3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PABPC3 Gene

ENSEMBL:
Gene Tree for PABPC3 (if available)
TreeFam:
Gene Tree for PABPC3 (if available)

Paralogs for PABPC3 Gene

(15) SIMAP similar genes for PABPC3 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PABPC3 Gene

genes like me logo Genes that share paralogs with PABPC3: view

Variants for PABPC3 Gene

Structural Variations from Database of Genomic Variants (DGV) for PABPC3 Gene

Variant ID Type Subtype PubMed ID
nsv435952 OTHER Inversion 17901297
esv2747161 CNV Deletion 23290073
nsv899942 CNV Gain 21882294
dgv7e24 CNV Loss 17666407
esv2659512 CNV Deletion 23128226

Variation tolerance for PABPC3 Gene

Residual Variation Intolerance Score: 94.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.73; 89.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PABPC3 Gene

HapMap Linkage Disequilibrium report
PABPC3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PABPC3 Gene

Disorders for PABPC3 Gene

Relevant External Links for PABPC3

Genetic Association Database (GAD)
PABPC3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PABPC3

No disorders were found for PABPC3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PABPC3 Gene

Publications for PABPC3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Chromosomal localization of three human poly(A)-binding protein genes and four related pseudogenes. (PMID: 10543404) FAcral C. … GuellaAn G. (Hum. Genet. 1999) 2 3
  3. Localization of the human poly(A)-binding protein gene (PAB1) to chromosomal regions 3q22-q25, 12q13-q14, and 13q12-q13 by in situ hybridization. (PMID: 8432538) Morris C.M. … Bodger M.P. (Genomics 1993) 2 3
  4. DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. (PMID: 25756610) Papp S.J. … Lamia K.A. (Elife 2015) 3
  5. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for PABPC3 Gene

Sources for PABPC3 Gene

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