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Aliases for PABPC1L2B Gene

Aliases for PABPC1L2B Gene

  • Poly(A) Binding Protein, Cytoplasmic 1-Like 2B 2 3
  • RNA Binding Motif Protein 32B 2 3
  • RNA-Binding Motif Protein 32 3 4
  • RNA-Binding Protein 32 3 4
  • RBM32B 3 4
  • Polyadenylate-Binding Protein 1-Like 2 3
  • PABPC1L2A PABPC1L2B 4
  • PABPC1L2 4
  • RBM32A 4

External Ids for PABPC1L2B Gene

Previous HGNC Symbols for PABPC1L2B Gene

  • RBM32B

Previous GeneCards Identifiers for PABPC1L2B Gene

  • GC0XP072139
  • GC0XP072223
  • GC0XP065860

Summaries for PABPC1L2B Gene

GeneCards Summary for PABPC1L2B Gene

PABPC1L2B (Poly(A) Binding Protein, Cytoplasmic 1-Like 2B) is a Protein Coding gene. Among its related pathways are RNA transport and Deadenylation-dependent mRNA decay. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is PABPC1L2A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC1L2B Gene

Genomics for PABPC1L2B Gene

Regulatory Elements for PABPC1L2B Gene

Genomic Location for PABPC1L2B Gene

Start:
73,003,513 bp from pter
End:
73,005,713 bp from pter
Size:
2,201 bases
Orientation:
Plus strand

Genomic View for PABPC1L2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PABPC1L2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC1L2B Gene

Proteins for PABPC1L2B Gene

  • Protein details for PABPC1L2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JQF8-PAP1M_HUMAN
    Recommended name:
    Polyadenylate-binding protein 1-like 2
    Protein Accession:
    Q5JQF8
    Secondary Accessions:
    • B2RMV9
    • Q8IVU8

    Protein attributes for PABPC1L2B Gene

    Size:
    200 amino acids
    Molecular mass:
    22799 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May be not functional as it lacks the poly(A)-binding protein C-terminal (PABC) domain implicated in the mRNA stability and translation regulation
    SequenceCaution:
    • Sequence=AAH41956.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PABPC1L2B Gene

Proteomics data for PABPC1L2B Gene at MOPED

Post-translational modifications for PABPC1L2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PABPC1L2B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PABPC1L2B Gene

Domains for PABPC1L2B Gene

Gene Families for PABPC1L2B Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for PABPC1L2B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PABPC1L2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5JQF8

UniProtKB/Swiss-Prot:

PAP1M_HUMAN :
  • Q5JQF8
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with PABPC1L2B: view

Function for PABPC1L2B Gene

Gene Ontology (GO) - Molecular Function for PABPC1L2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with PABPC1L2B: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PABPC1L2B Gene

Localization for PABPC1L2B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PABPC1L2B Gene COMPARTMENTS Subcellular localization image for PABPC1L2B gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PABPC1L2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with PABPC1L2B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PABPC1L2B Gene

Pathways for PABPC1L2B Gene

genes like me logo Genes that share pathways with PABPC1L2B: view

Pathways by source for PABPC1L2B Gene

3 KEGG pathways for PABPC1L2B Gene

Interacting Proteins for PABPC1L2B Gene

Gene Ontology (GO) - Biological Process for PABPC1L2B Gene

None

Transcripts for PABPC1L2B Gene

mRNA/cDNA for PABPC1L2B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPC1L2B Gene

Poly(A) binding protein, cytoplasmic 1-like 2B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC1L2B Gene

No ASD Table

Relevant External Links for PABPC1L2B Gene

GeneLoc Exon Structure for
PABPC1L2B
ECgene alternative splicing isoforms for
PABPC1L2B

Expression for PABPC1L2B Gene

mRNA expression in normal human tissues for PABPC1L2B Gene

mRNA differential expression in normal tissues according to GTEx for PABPC1L2B Gene

This gene is overexpressed in Brain - Hypothalamus (7.1), Brain - Frontal Cortex (BA9) (6.4), Brain - Anterior cingulate cortex (BA24) (5.7), and Brain - Cortex (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PABPC1L2B Gene

SOURCE GeneReport for Unigene cluster for PABPC1L2B Gene Hs.567854

genes like me logo Genes that share expressions with PABPC1L2B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PABPC1L2B Gene

Orthologs for PABPC1L2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PABPC1L2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 96 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 99 (a)
ManyToMany
-- 36
  • 99 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSH49 36
  • 21 (a)
OneToMany
Species with no ortholog for PABPC1L2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PABPC1L2B Gene

ENSEMBL:
Gene Tree for PABPC1L2B (if available)
TreeFam:
Gene Tree for PABPC1L2B (if available)

Paralogs for PABPC1L2B Gene

Paralogs for PABPC1L2B Gene

Selected SIMAP similar genes for PABPC1L2B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PABPC1L2B: view

Variants for PABPC1L2B Gene

Sequence variations from dbSNP and Humsavar for PABPC1L2B Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs4892374 -- 73,005,754(+) GGCTT(C/G)ATAGA downstream-variant-500B
rs35495242 -- 73,005,349(-) CAGGG(-/G)AAACA utr-variant-3-prime
rs35870611 -- 73,005,722(-) AACAT(-/G)CCATG downstream-variant-500B
rs139776847 -- 73,005,391(+) TTTAT(G/T)ACCCC utr-variant-3-prime
rs141974740 -- 73,005,351(+) GTTTC(C/G)CTGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PABPC1L2B Gene

Variant ID Type Subtype PubMed ID
nsv7451 OTHER Inversion 18451855
dgv1253n67 CNV Gain 20364138
nsv508782 CNV Insertion 20534489
nsv499562 OTHER Inversion 21111241
nsv829379 CNV Gain 20364138

Relevant External Links for PABPC1L2B Gene

HapMap Linkage Disequilibrium report
PABPC1L2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPC1L2B Gene

Disorders for PABPC1L2B Gene

No disorders were found for PABPC1L2B Gene.

No data available for UniProtKB/Swiss-Prot for PABPC1L2B Gene

Publications for PABPC1L2B Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4

Products for PABPC1L2B Gene

Sources for PABPC1L2B Gene

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