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Aliases for PABPC1L2A Gene

Aliases for PABPC1L2A Gene

  • Poly(A) Binding Protein Cytoplasmic 1 Like 2A 2 3
  • Poly(A) Binding Protein, Cytoplasmic 1-Like 2A 2 3 5
  • RNA Binding Motif Protein 32A 2 3
  • RNA-Binding Motif Protein 32 3 4
  • RNA-Binding Protein 32 3 4
  • RBM32A 3 4
  • PABPC1L2A PABPC1L2B 4
  • PABPC1L2 4
  • RBM32B 4

External Ids for PABPC1L2A Gene

Previous HGNC Symbols for PABPC1L2A Gene

  • RBM32A

Previous GeneCards Identifiers for PABPC1L2A Gene

  • GC0XM072216
  • GC0XM072297
  • GC0XM065931

Summaries for PABPC1L2A Gene

GeneCards Summary for PABPC1L2A Gene

PABPC1L2A (Poly(A) Binding Protein Cytoplasmic 1 Like 2A) is a Protein Coding gene. Among its related pathways are RNA transport and mRNA surveillance pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC1L2A Gene

Genomics for PABPC1L2A Gene

Regulatory Elements for PABPC1L2A Gene

Genomic Location for PABPC1L2A Gene

Chromosome:
X
Start:
73,077,276 bp from pter
End:
73,079,512 bp from pter
Size:
2,237 bases
Orientation:
Minus strand

Genomic View for PABPC1L2A Gene

Genes around PABPC1L2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PABPC1L2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PABPC1L2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC1L2A Gene

Proteins for PABPC1L2A Gene

  • Protein details for PABPC1L2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JQF8-PAP1M_HUMAN
    Recommended name:
    Polyadenylate-binding protein 1-like 2
    Protein Accession:
    Q5JQF8
    Secondary Accessions:
    • B2RMV9
    • Q8IVU8

    Protein attributes for PABPC1L2A Gene

    Size:
    200 amino acids
    Molecular mass:
    22799 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May be not functional as it lacks the poly(A)-binding protein C-terminal (PABC) domain implicated in the mRNA stability and translation regulation.
    SequenceCaution:
    • Sequence=AAH41956.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PABPC1L2A Gene

Proteomics data for PABPC1L2A Gene at MOPED

Post-translational modifications for PABPC1L2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PABPC1L2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PABPC1L2A

No data available for DME Specific Peptides for PABPC1L2A Gene

Domains & Families for PABPC1L2A Gene

Gene Families for PABPC1L2A Gene

Protein Domains for PABPC1L2A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5JQF8

UniProtKB/Swiss-Prot:

PAP1M_HUMAN :
  • Contains 2 RRM (RNA recognition motif) domains.
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.
genes like me logo Genes that share domains with PABPC1L2A: view

No data available for Suggested Antigen Peptide Sequences for PABPC1L2A Gene

Function for PABPC1L2A Gene

Gene Ontology (GO) - Molecular Function for PABPC1L2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding IEA --
genes like me logo Genes that share ontologies with PABPC1L2A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PABPC1L2A Gene

Localization for PABPC1L2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PABPC1L2A Gene COMPARTMENTS Subcellular localization image for PABPC1L2A gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PABPC1L2A Gene

Pathways & Interactions for PABPC1L2A Gene

genes like me logo Genes that share pathways with PABPC1L2A: view

Pathways by source for PABPC1L2A Gene

3 KEGG pathways for PABPC1L2A Gene

Interacting Proteins for PABPC1L2A Gene

Gene Ontology (GO) - Biological Process for PABPC1L2A Gene

None

No data available for SIGNOR curated interactions for PABPC1L2A Gene

Drugs & Compounds for PABPC1L2A Gene

No Compound Related Data Available

Transcripts for PABPC1L2A Gene

mRNA/cDNA for PABPC1L2A Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPC1L2A Gene

Poly(A) binding protein, cytoplasmic 1-like 2A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC1L2A Gene

No ASD Table

Relevant External Links for PABPC1L2A Gene

GeneLoc Exon Structure for
PABPC1L2A
ECgene alternative splicing isoforms for
PABPC1L2A

Expression for PABPC1L2A Gene

mRNA expression in normal human tissues for PABPC1L2A Gene

mRNA differential expression in normal tissues according to GTEx for PABPC1L2A Gene

This gene is overexpressed in Brain - Hypothalamus (x6.6), Brain - Frontal Cortex (BA9) (x5.7), Brain - Anterior cingulate cortex (BA24) (x5.3), and Brain - Cortex (x4.6).

Protein differential expression in normal tissues from HIPED for PABPC1L2A Gene

This gene is overexpressed in Tlymphocyte (28.5), Heart (18.4), Brain (12.4), and Frontal cortex (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PABPC1L2A Gene



SOURCE GeneReport for Unigene cluster for PABPC1L2A Gene Hs.450320

genes like me logo Genes that share expression patterns with PABPC1L2A: view

Protein tissue co-expression partners for PABPC1L2A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PABPC1L2A Gene

Orthologs for PABPC1L2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PABPC1L2A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PABPC1L2A 35
  • 95.17 (n)
  • 99 (a)
-- 36
  • 99 (a)
ManyToMany
-- 36
  • 99 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Pabpc1l2b-ps 35
  • 91.46 (n)
  • 93.97 (a)
Pabpc1l2b-ps 16
rat
(Rattus norvegicus)
Mammalia Pabpc1l2a 35
  • 91.29 (n)
  • 93.47 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 21 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 96 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSH49 36
  • 21 (a)
OneToMany
Species with no ortholog for PABPC1L2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PABPC1L2A Gene

ENSEMBL:
Gene Tree for PABPC1L2A (if available)
TreeFam:
Gene Tree for PABPC1L2A (if available)

Paralogs for PABPC1L2A Gene

(11) SIMAP similar genes for PABPC1L2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PABPC1L2A: view

Variants for PABPC1L2A Gene

Sequence variations from dbSNP and Humsavar for PABPC1L2A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs3117680 -- 73,077,789(+) AGGAG(A/G)CTATG utr-variant-3-prime
rs11093406 -- 73,077,578(+) TTTTC(C/T)TGCAA utr-variant-3-prime
rs11093407 -- 73,077,702(+) CTTTG(C/T)AGCCC utr-variant-3-prime
rs141350054 -- 73,077,754(+) ACACG(A/C)ACGCA utr-variant-3-prime
rs150942695 -- 73,077,491(+) ATGTT(C/T)CTGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PABPC1L2A Gene

Variant ID Type Subtype PubMed ID
nsv7451 OTHER Inversion 18451855
nsv499562 OTHER Inversion 21111241
nsv829380 CNV Gain 20364138

Relevant External Links for PABPC1L2A Gene

HapMap Linkage Disequilibrium report
PABPC1L2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for PABPC1L2A Gene

Disorders for PABPC1L2A Gene

Relevant External Links for PABPC1L2A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PABPC1L2A

No disorders were found for PABPC1L2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PABPC1L2A Gene

Publications for PABPC1L2A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3

Products for PABPC1L2A Gene

Sources for PABPC1L2A Gene

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