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PABPC1L2A Gene

protein-coding   GIFtS: 37

GC0XM072216
poly(A) binding protein, cytoplasmic 1-like 2A
(Previous name: RNA binding motif protein 32A )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RBM32A)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
MGC168104 2
OTTHUMP00000023563 2
PABPC1L2 3
RBM32A 2, 3
RBM32B 3
Descriptions
RNA binding motif protein 32A 1, 2
RNA-binding motif protein 32 3
RNA-binding protein 32 3
poly(A) binding protein, cytoplasmic 1-like 2A 2
External Ids
HGNC: 279891
Entrez Gene: 3405292
UniProtKB: Q5JQF83
Ensembl: ENSG000001862887
Search outside databases for aliases for PABPC1L2A gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.2   Ensembl cytogenetic band:  Xq13.2   HGNC cytogenetic band: Xq13.2

PABPC1L2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM072216:     (about GC identifiers)

Start:
72,213,840 bp from pter
End:
72,216,076 bp from pter
Size:
2,237 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000023.9  NT_011669.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PAP1M_HUMAN, Q5JQF8 (See protein sequence)
Recommended Name: Polyadenylate-binding protein 1-like 2  
Size: 200 amino acids; 22799 Da
Miscellaneous: May be not functional as it lacks the poly(A)-binding protein C-terminal (PABC)
domain implicated in the mRNA stability and translation regulation
Secondary accessions: B2RMV9 Q8IVU8

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_001012995.1  

    ENSEMBL proteins: 
    ENSP00000362618 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (RP11-493K23.2)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for PABPC1L2A: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Monoclonal and Polyclonal Antibodies from Abnova (RP11-493K23.2)
    Novus Biologicals Antibody for PABPC1L2A

    Assays for PABPC1L2A: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    2 InterPro domains/families:
     IPR000504 RRM_RNP1
     IPR012677 a_b_plait_nuc_bd


       GeneDecks  PABPC1L2A for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q5JQF8

    ProtoNet protein and cluster: Q5JQF8

    UniProtKB/Swiss-Prot: PAP1M_HUMAN, Q5JQF8
    Similarity: Contains 2 RRM (RNA recognition motif) domains

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (PABPC1L2A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RP11-493K23.2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_291328

                  Applied Biosystems Silencer® siRNAs for PABPC1L2A

                  Sigma-Aldrich siRNA for PABPC1L2A  
                         Sigma-Aldrich shRNA for PABPC1L2A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for PABPC1L2A
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001012977
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001012977
                                     untagged cDNA clone in CMV expression vector: NM_001012977 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001012977

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


      --
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for PABPC1L2A

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (PABPC1L2A)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (RP11-493K23.2)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): XM_291328

                  Sigma-Aldrich siRNA for PABPC1L2A  
                         Sigma-Aldrich shRNA for PABPC1L2A  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001012977  

    REFSEQ mRNAs for PABPC1L2A gene: 

    NM_001012977.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001012977  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_001012977
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_001012977
                                     untagged cDNA clone in CMV expression vector: NM_001012977 

    Additional cDNA sequence: AY730282.1 

    2 DOTS entries:

    DT.40272099  DT.95305166 

    4 AceView cDNA sequences:

    BC041956 BI599244 AA322840 AV726960 

    Unigene Cluster for PABPC1L2A:

    Poly(A) binding protein, cytoplasmic 1-like 2A
    Hs.450320  [show with all ESTs]
    Unigene Representative Sequence: NM_001012977


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000373519  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    PABPC1L2A expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for PABPC1L2A

    1Data from GNF BioGPS
        About these images

    About these images

    CGAP SAGE TAG: CACACCTCTC

    SOURCE GeneReport for Unigene cluster: Hs.450320
    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for PABPC1L2A gene from 3 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    cow
    (Bos taurus)
    LOC7844381   -- similar to PABPC1L2B protein 95(n)
    98.5(a)
    784438  XM_001252745.1  XP_001252746.1 
    rat
    (Rattus norvegicus)
    Pabpc1l2b1   -- poly(A) binding protein, cytoplasmic 1-like 2B 91.29(n)
    93.47(a)
    302405  XM_228576.3  XP_228576.2 
    mouse
    (Mus musculus)
    Pabpc1l2a1   -- poly(A) binding protein, cytoplasmic 1-like 2A 91.45(n)
    94.36(a)
    245545  XM_141989.6  XP_141989.4 
    About this table        Species with no ortholog for PABPC1L2A

    ENSEMBL Gene Tree for PABPC1L2A
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for PABPC1L2A gene
    PABPC1L2B1 2  PABPC1L2  PABPC32  PABPC52  PABPCP52  PABPCP22  PABPC42  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    5 NCBI SNPs in PABPC1L2A are shown
    (Click for Applied Biosystems TaqMan ® Genotyping Assay) (only AB snps)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs110934061,2
    A,F,H72214142(+) TTTTCT/CTGCAA 1 -- ut31 ese3 trp34Minor allele frequency- C:0.19EU EA WA 388
    --
    rs110934071,2
    A,C72214266(+) CTTTGC/TAGCCC 1 -- ut31 ese30--------
    --
    rs31176801,2
    O72214353(+) AGGAGA/GCTATG 1 -- ut31 ese30--------
    --
    rs48925341,2
    C72214624(+) TGTCCA/GACAAT 1 -- ut310--------
    --
    rs721725101,2
    --72214317(+) ACACG-/ACCACGC 1 -- ut310--------
    About this table
    The following additional 6 SNP(s) have been found in Applied Biosystems data source:
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)


     rs3130873 rs4466574 rs5937924 rs3130872 rs3130866 rs17265553

    HapMap Linkage Disequilibrium images for PABPC1L2A (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    3 PubMed articles for PABPC1L2A gene:
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 340529 HGNC: 27989 AceView: LOC340529 Ensembl:ENSG00000186288 euGenes: HUgn340529
    ECgene: PABPC1L2A H-InvDB: PABPC1L2A
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for PABPC1L2A:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for PABPC1L2A-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for PABPC1L2A Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for PABPC1L2A Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

     Recombinant Proteins (RP11-493K23.2)
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     Chimera RNAi (RP11-493K23.2)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
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     Antibodies for PABPC1L2A

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