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Aliases for PABPC1L2A Gene

Aliases for PABPC1L2A Gene

  • Poly(A) Binding Protein, Cytoplasmic 1-Like 2A 2 3
  • RNA Binding Motif Protein 32A 2 3
  • RNA-Binding Motif Protein 32 3 4
  • RNA-Binding Protein 32 3 4
  • RBM32A 3 4
  • Polyadenylate-Binding Protein 1-Like 2 3
  • PABPC1L2A PABPC1L2B 4
  • PABPC1L2 4
  • RBM32B 4

External Ids for PABPC1L2A Gene

Previous Symbols for PABPC1L2A Gene

  • RBM32A

Summaries for PABPC1L2A Gene

GeneCards Summary for PABPC1L2A Gene

PABPC1L2A (Poly(A) Binding Protein, Cytoplasmic 1-Like 2A) is a Protein Coding gene. Among its related pathways are RNA transport and Deadenylation-dependent mRNA decay. An important paralog of this gene is PUF60.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC1L2A Gene

Genomics for PABPC1L2A Gene

Genomic Location for PABPC1L2A Gene

Start:
73,077,276 bp from pter
End:
73,079,512 bp from pter
Size:
2,237 bases
Orientation:
Minus strand

Genomic View for PABPC1L2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PABPC1L2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC1L2A Gene

Regulatory Elements for PABPC1L2A Gene

Proteins for PABPC1L2A Gene

  • Protein details for PABPC1L2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JQF8-PAP1M_HUMAN
    Recommended name:
    Polyadenylate-binding protein 1-like 2
    Protein Accession:
    Q5JQF8
    Secondary Accessions:
    • B2RMV9
    • Q8IVU8

    Protein attributes for PABPC1L2A Gene

    Size:
    200 amino acids
    Molecular mass:
    22799 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May be not functional as it lacks the poly(A)-binding protein C-terminal (PABC) domain implicated in the mRNA stability and translation regulation
    SequenceCaution:
    • Sequence=AAH41956.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PABPC1L2A Gene

Proteomics data for PABPC1L2A Gene at MOPED

Post-translational modifications for PABPC1L2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PABPC1L2A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PABPC1L2A Gene

Domains for PABPC1L2A Gene

Gene Families for PABPC1L2A Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for PABPC1L2A Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5JQF8

UniProtKB/Swiss-Prot:

PAP1M_HUMAN
Domain:
  • Contains 2 RRM (RNA recognition motif) domains.:
    • Q5JQF8
genes like me logo Genes that share domains with PABPC1L2A: view

No data available for Suggested Antigen Peptide Sequences for PABPC1L2A Gene

Function for PABPC1L2A Gene

Gene Ontology (GO) - Molecular Function for PABPC1L2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with PABPC1L2A: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PABPC1L2A Gene

Localization for PABPC1L2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PABPC1L2A Gene COMPARTMENTS Subcellular localization image for PABPC1L2A gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PABPC1L2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with PABPC1L2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PABPC1L2A Gene

Pathways for PABPC1L2A Gene

genes like me logo Genes that share pathways with PABPC1L2A: view

Pathways by source for PABPC1L2A Gene

3 KEGG pathways for PABPC1L2A Gene

Interacting Proteins for PABPC1L2A Gene

Gene Ontology (GO) - Biological Process for PABPC1L2A Gene

None

Transcripts for PABPC1L2A Gene

mRNA/cDNA for PABPC1L2A Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPC1L2A Gene

Poly(A) binding protein, cytoplasmic 1-like 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC1L2A Gene

No ASD Table

Relevant External Links for PABPC1L2A Gene

GeneLoc Exon Structure for
PABPC1L2A
ECgene alternative splicing isoforms for
PABPC1L2A

Expression for PABPC1L2A Gene

mRNA expression in normal human tissues for PABPC1L2A Gene

mRNA differential expression in normal tissues according to GTEx for PABPC1L2A Gene

This gene is overexpressed in Brain - Hypothalamus (6.6), Brain - Frontal Cortex (BA9) (5.7), Brain - Anterior cingulate cortex (BA24) (5.3), and Brain - Cortex (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PABPC1L2A Gene

SOURCE GeneReport for Unigene cluster for PABPC1L2A Gene Hs.450320

genes like me logo Genes that share expressions with PABPC1L2A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PABPC1L2A Gene

Orthologs for PABPC1L2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PABPC1L2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 96 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 36
  • 99 (a)
ManyToMany
-- 36
  • 99 (a)
ManyToMany
PABPC1L2A 35
  • 95.17 (n)
  • 99 (a)
mouse
(Mus musculus)
Mammalia Pabpc1l2b-ps 35
  • 91.46 (n)
  • 93.97 (a)
Pabpc1l2b-ps 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 21 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Pabpc1l2a 35
  • 91.29 (n)
  • 93.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HSH49 36
  • 21 (a)
OneToMany
Species with no ortholog for PABPC1L2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PABPC1L2A Gene

ENSEMBL:
Gene Tree for PABPC1L2A (if available)
TreeFam:
Gene Tree for PABPC1L2A (if available)

Paralogs for PABPC1L2A Gene

Paralogs for PABPC1L2A Gene

Selected SIMAP similar genes for PABPC1L2A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with PABPC1L2A: view

Variants for PABPC1L2A Gene

Sequence variations from dbSNP and Humsavar for PABPC1L2A Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs3117680 -- 73,077,789(+) AGGAG(A/G)CTATG utr-variant-3-prime
rs11093406 -- 73,077,578(+) TTTTC(C/T)TGCAA utr-variant-3-prime
rs11093407 -- 73,077,702(+) CTTTG(C/T)AGCCC utr-variant-3-prime
rs141350054 -- 73,077,754(+) ACACG(A/C)ACGCA utr-variant-3-prime
rs150942695 -- 73,077,491(+) ATGTT(C/T)CTGGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for PABPC1L2A Gene

Variant ID Type Subtype PubMed ID
nsv7451 OTHER Inversion 18451855
nsv499562 OTHER Inversion 21111241
nsv829380 CNV Gain 20364138

Relevant External Links for PABPC1L2A Gene

HapMap Linkage Disequilibrium report
PABPC1L2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPC1L2A Gene

Disorders for PABPC1L2A Gene

No disorders were found for PABPC1L2A Gene.

No data available for UniProtKB/Swiss-Prot for PABPC1L2A Gene

Publications for PABPC1L2A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S. … Drake R.R. (Proteomics 2013) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4

Products for PABPC1L2A Gene

Sources for PABPC1L2A Gene

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