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PABPC1L Gene

protein-coding GIFtS: 38

GC20P042973

poly(A) binding protein, cytoplasmic 1-like
(Previous name: chromosome 20 open reading frame 119 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C20orf119)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
C20orf119 ^², ³
FLJ11840 ^²
FLJ30809 ^²
FLJ42053 ^²
OTTHUMP00000063224 ^²
PABPC1L1 ^¹, ²
dJ1069P2.3 ^¹, ²
ePAB ^²

Descriptions
chromosome 20 open reading frame 119 ^¹
poly(A) binding protein, cytoplasmic 1-like ^²
poly(A)-binding protein, cytoplasmic 1-like ^²

External Ids
HGNC: 15797¹
Entrez Gene: 80336²
UniProtKB: Q4VXU2³
Ensembl: ENSG00000101104⁷

Search outside databases for aliases for PABPC1L gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Ensembl cytogenetic band: 20q13.12 HGNC cytogenetic band: 20q12-q13.1

PABPC1L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P042973: (about GC identifiers)

Start:	42,972,117 bp from pter
End:	43,021,090 bp from pter
Size:	48,974 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: PAP1L_HUMAN, Q4VXU2 (See protein sequence)

Recommended Name: Polyadenylate-binding protein 1-like

Size: 614 amino acids; 68392 Da

REFSEQ proteins: NP_001118228.1

ENSEMBL proteins:

ENSP00000361909 ENSP00000361911 ENSP00000361913 ENSP00000217075 ENSP00000361908 ENSP00000217074

ENSP00000217073 ENSP00000361906 ENSP00000255136

Human Recombinant Proteins

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Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for PABPC1L:

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	Search Novus for antibodies for PABPC1L

Assays for PABPC1L:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q4VXU2

ProtoNet protein and cluster: Q4VXU2

1 Blocks protein family: IPB002004 Polyadenylate-binding protein/HECT-associated

UniProtKB/Swiss-Prot: PAP1L_HUMAN, Q4VXU2

Similarity: Belongs to the polyadenylate-binding protein type-1 family

Similarity: Contains 1 PABC domain

Similarity: Contains 4 RRM (RNA recognition motif) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001124756

Applied Biosystems Silencer® siRNAs for PABPC1L

Browse siRNA at Sigma-Aldrich

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001124756
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001124756
untagged cDNA clones in CMV expression vector (see all 2): NM_001124756

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001124756

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003723	RNA binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Interacting protein for PABPC1L (ENSP00000217073³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AP3B2	ENSP00000261722³	STRING (score=.708)

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PABPC1L

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Browse Invitrogen for RNAi
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001124756

Browse siRNA at Sigma-Aldrich

Browse shRNA at Sigma-Aldrich

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001124756

REFSEQ mRNAs for PABPC1L gene:

NM_001124756.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001124756

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001124756
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001124756
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001124756

Additional cDNA sequence:

AK021902.1 AK026760.1 AK055371.2 AK124047.1 BC039151.1 BC068104.1 EU190483.1

15 DOTS entries:

DT.40121548 DT.75150161 DT.455433 DT.92072019 DT.95167259 DT.100735485 DT.100810993 DT.100693076

DT.120828515 DT.86854580 DT.91931313 DT.92426513 DT.97842630 DT.431772 DT.91849504

Unigene Cluster for PABPC1L:

Poly(A) binding protein, cytoplasmic 1-like

Hs.641481 [show with all ESTs]

Unigene Representative Sequence: AK124047

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PABPC1L (see all 6 )

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5a	·	5b	^	6a	·	6b	·	6c	^	7	^	8a	·	8b	^	9a	·	9b	^	10
SP1:																									-		-		-
SP2:																									-				-
SP3:													-		-
SP4:																									-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for PABPC1L

9 Ensembl transcripts including schematic representations:

ENST00000372822 ENST00000372824 ENST00000372826 ENST00000217075 ENST00000372821 ENST00000217074

ENST00000217073 ENST00000372819 ENST00000255136

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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PABPC1L expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PABPC1L

¹ / ²

12 probe-sets matching PABPC1L gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
44777_at²	U95-B	1	1.00	1.00	0.96	0.83	--	--	--	--	--
59293_at²	U95-C	1	1.00	1.00	0.98	1.06	--	--	--	--	--
76041_g_at²	U95-E	1	1.00	1.00	0.99	1.25	--	--	--	--	--
76038_at²	U95-E	1	1.00	1.00	0.98	0.99	--	--	--	--	--
44778_g_at²	U95-B	1	1.00	1.00	0.96	1.14	--	--	--	--	--
79405_at²	U95-E	1	0.50	1.00	0.96	0.74	--	--	--	--	--
226670_s_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
231838_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
233104_at²	U133-B	1	1.00	1.00	--	--	--	--	--	--	--
226670_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
231838_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
233104_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks PABPC1L for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCTGCCAAAA

SOURCE GeneReport for Unigene cluster: Hs.641481

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for PABPC1L gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PABPC1L¹	--	poly(A) binding protein, cytoplasmic 1-like	88.14(n) 88.3(a)	477238 XM_534430.2 XP_534430.2
chimpanzee (Pan troglodytes)	PABPC1L¹	--	poly(A) binding protein, cytoplasmic 1-like	99.57(n) 99.84(a)	458273 XM_514668.2 XP_514668.2
cow (Bos taurus)	PABPC1L¹	--	poly(A) binding protein, cytoplasmic 1-like	88.48(n) 88.93(a)	509864 XM_877205.2 XP_882298.2
mouse (Mus musculus)	Pabpc1l⁵	2	poly(A) binding protein, cytoplasmic 1-like	--	EU669908
chicken (Gallus gallus)	PABPC1L¹	--	poly(A) binding protein, cytoplasmic 1-like	75.8(n) 78.41(a)	419189 XM_417367.2 XP_417367.2

About this table Species with no ortholog for PABPC1L

ENSEMBL Gene Tree for PABPC1L

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PABPC1L gene

PABPC3² PABPC5² PABPC1L2B² PABPCP5² PABPCP2² PABPC4² PABPC1L2A²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/18 NCBI SNPs in PABPC1L are shown (see all 18 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 133)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs11540856^1,2	C,F,H	43001219(-)	`AAACAC/GTGTCC`	1	--	ut3¹ ese³		8	EU EA WA	804
	rs2075960^1,2	C,F,H	42981091(+)	`TCTTCT/GCCCAG`	1	A/S	mis¹ ese³ trp³		17	EA NA EU WA	2072
	rs6513956^1,2	A,C,H	42997475(+)	`GACCCA/GGTGGG`	1	S/G	mis¹ ese³		4	EU EA WA	418
	rs2072727^1,2	C,F	42972147(+)	`GGGGCT/CGCTGG`	1	--	ut5¹ ese³		3	EA NA	60
	rs2664552^1,2	H	43001231(-)	`GCTGAG/AAGCCA`	1	--	ut3¹ ese³		4	EU EA WA	420
	rs2664530^1,2	H	43001225(-)	`AGCCAG/AAAACA`	1	--	ut3¹ ese³		4	EU EA WA	406
--	rs11780^1,2	A,C,F,H	43000201(+)	`AACTCA/GGAGCT`	1	S/S	syn¹ ese³		18	MN EA NA EU WA	2990
	rs3827098^1,2	C,F,H	42983660(+)	`GTCCAT/CATGAA`	1	H/H	syn¹ ese³		8	EA NA EU WA	2056
	rs3746581^1,2	H	42992613(+)	`CGCATC/TGTGGG`	1	I/I	syn¹ ese³		4	EU EA WA	418
	rs6031865^1,2	H	42972363(+)	`TACGCC/TTACAT`	1	A/A	syn¹ ese³		4	EU EA WA	408

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HapMap Linkage Disequilibrium images for PABPC1L (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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5 PubMed articles for PABPC1L gene:

The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. (PubMed id 11549316)^{2, 3} Fossey S.C....Bowden D.W. (2001)
Identification and characterization of human embryonic poly(A) binding protein (EPAB). (PubMed id 18716053)³ Guzeloglu-Kayisli O....Seli E. (2008)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)³ Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 80336	HGNC: 15797	Ensembl:ENSG00000101104	euGenes: HUgn80336	ECgene: PABPC1L
H-InvDB: PABPC1L

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for PABPC1L
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for PABPC1L:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PABPC1L-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Browse siRNAs at Sigma-Aldrich		Browse antibodies at Sigma-Aldrich
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	Recombinant & Natural Proteins

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PABPC1L Gene

protein-coding GIFtS: 38

Aliases &
Descriptions
for PABPC1L

Summaries
for PABPC1L

Genomic Location
for PABPC1L

Proteins
for PABPC1L

Protein Domains/
Families
for PABPC1L

Gene Function
for PABPC1L

Pathways & Interactions
for PABPC1L

Drugs & Compounds
for PABPC1L

Transcripts
for PABPC1L

Expression
for PABPC1L

Orthologs
for PABPC1L

Paralogs
for PABPC1L

SNPs/Variants
for PABPC1L

Disorders & Mutations
for PABPC1L

Medical News
for PABPC1L

Publications
for PABPC1L

Search for PABPC1L

Genome Databases showing PABPC1L

Other Databases showing PABPC1L

Specialized Databases showing PABPC1L

Licensable Technologies
for PABPC1L

Services
for PABPC1L

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PABPC1L Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor PABPC1L

Summariesfor PABPC1L

Genomic Locationfor PABPC1L

Proteinsfor PABPC1L

Protein Domains/Familiesfor PABPC1L

Gene Functionfor PABPC1L

Pathways & Interactionsfor PABPC1L

Drugs & Compoundsfor PABPC1L

Transcriptsfor PABPC1L

Expression for PABPC1L

Orthologsfor PABPC1L

Paralogsfor PABPC1L

SNPs/Variantsfor PABPC1L

Disorders & Mutationsfor PABPC1L

Medical Newsfor PABPC1L

Publicationsfor PABPC1L

Search for PABPC1L

Genome Databases showing PABPC1L

Other Databases showing PABPC1L

Specialized Databases showing PABPC1L

Licensable Technologiesfor PABPC1L

Servicesfor PABPC1L

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PABPC1L

Summaries
for PABPC1L

Genomic Location
for PABPC1L

Proteins
for PABPC1L

Protein Domains/
Families
for PABPC1L

Gene Function
for PABPC1L

Pathways & Interactions
for PABPC1L

Drugs & Compounds
for PABPC1L

Transcripts
for PABPC1L

Expression
for PABPC1L

Orthologs
for PABPC1L

Paralogs
for PABPC1L

SNPs/Variants
for PABPC1L

Disorders & Mutations
for PABPC1L

Medical News
for PABPC1L

Publications
for PABPC1L

Licensable Technologies
for PABPC1L

Services
for PABPC1L