Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PABPC1L Gene

Aliases for PABPC1L Gene

  • Poly(A) Binding Protein Cytoplasmic 1 Like 2 3
  • Poly(A) Binding Protein, Cytoplasmic 1-Like 2 3 5
  • C20orf119 3 4
  • Chromosome 20 Open Reading Frame 119 2
  • Embryonic Poly(A) Binding Protein 3
  • DJ1069P2.3 3
  • PABPC1L1 3
  • EPAB 3

External Ids for PABPC1L Gene

Previous HGNC Symbols for PABPC1L Gene

  • C20orf119

Previous GeneCards Identifiers for PABPC1L Gene

  • GC20P042973
  • GC20P043538
  • GC20P040280

Summaries for PABPC1L Gene

GeneCards Summary for PABPC1L Gene

PABPC1L (Poly(A) Binding Protein Cytoplasmic 1 Like) is a Protein Coding gene. Among its related pathways are RNA transport and mRNA surveillance pathway. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is PABPC1L2A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC1L Gene

Genomics for PABPC1L Gene

Regulatory Elements for PABPC1L Gene

Promoters for PABPC1L Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PABPC1L on UCSC Golden Path with GeneCards custom track

Genomic Location for PABPC1L Gene

Chromosome:
20
Start:
44,910,058 bp from pter
End:
44,959,035 bp from pter
Size:
48,978 bases
Orientation:
Plus strand

Genomic View for PABPC1L Gene

Genes around PABPC1L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PABPC1L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PABPC1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC1L Gene

Proteins for PABPC1L Gene

  • Protein details for PABPC1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VXU2-PAP1L_HUMAN
    Recommended name:
    Polyadenylate-binding protein 1-like
    Protein Accession:
    Q4VXU2
    Secondary Accessions:
    • Q4VY17

    Protein attributes for PABPC1L Gene

    Size:
    614 amino acids
    Molecular mass:
    68392 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PABPC1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PABPC1L Gene

Proteomics data for PABPC1L Gene at MOPED

Post-translational modifications for PABPC1L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PABPC1L Gene

Domains & Families for PABPC1L Gene

Gene Families for PABPC1L Gene

Protein Domains for PABPC1L Gene

Graphical View of Domain Structure for InterPro Entry

Q4VXU2

UniProtKB/Swiss-Prot:

PAP1L_HUMAN :
  • Contains 1 PABC domain.
  • Belongs to the polyadenylate-binding protein type-1 family.
Domain:
  • Contains 1 PABC domain.
  • Contains 4 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the polyadenylate-binding protein type-1 family.
genes like me logo Genes that share domains with PABPC1L: view

Function for PABPC1L Gene

Gene Ontology (GO) - Molecular Function for PABPC1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
genes like me logo Genes that share ontologies with PABPC1L: view

Phenotypes for PABPC1L Gene

genes like me logo Genes that share phenotypes with PABPC1L: view

Animal Models for PABPC1L Gene

MGI Knock Outs for PABPC1L:

Animal Model Products

CRISPR Products

miRNA for PABPC1L Gene

miRTarBase miRNAs that target PABPC1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PABPC1L Gene

Localization for PABPC1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PABPC1L Gene COMPARTMENTS Subcellular localization image for PABPC1L gene
Compartment Confidence
extracellular 5
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PABPC1L Gene

Pathways & Interactions for PABPC1L Gene

genes like me logo Genes that share pathways with PABPC1L: view

Pathways by source for PABPC1L Gene

3 KEGG pathways for PABPC1L Gene

Interacting Proteins for PABPC1L Gene

Gene Ontology (GO) - Biological Process for PABPC1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006378 mRNA polyadenylation IEA --
genes like me logo Genes that share ontologies with PABPC1L: view

No data available for SIGNOR curated interactions for PABPC1L Gene

Drugs & Compounds for PABPC1L Gene

No Compound Related Data Available

Transcripts for PABPC1L Gene

mRNA/cDNA for PABPC1L Gene

(7) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPC1L Gene

Poly(A) binding protein, cytoplasmic 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC1L Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6: -

Relevant External Links for PABPC1L Gene

GeneLoc Exon Structure for
PABPC1L
ECgene alternative splicing isoforms for
PABPC1L

Expression for PABPC1L Gene

mRNA expression in normal human tissues for PABPC1L Gene

mRNA differential expression in normal tissues according to GTEx for PABPC1L Gene

This gene is overexpressed in Liver (x4.0).

Protein differential expression in normal tissues from HIPED for PABPC1L Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PABPC1L Gene



SOURCE GeneReport for Unigene cluster for PABPC1L Gene Hs.641481

genes like me logo Genes that share expression patterns with PABPC1L: view

Protein tissue co-expression partners for PABPC1L Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PABPC1L Gene

Orthologs for PABPC1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PABPC1L Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PABPC1L 35
  • 88.45 (n)
  • 88.78 (a)
PABPC1L 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PABPC1L 35
  • 88.14 (n)
  • 88.3 (a)
PABPC1L 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pabpc1l 35
  • 81.57 (n)
  • 78.73 (a)
Pabpc1l 16
Pabpc1l 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PABPC1L 35
  • 99.57 (n)
  • 99.84 (a)
PABPC1L 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pabpc1l 35
  • 81.45 (n)
  • 78.9 (a)
oppossum
(Monodelphis domestica)
Mammalia PABPC1L 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PABPC1L 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves PABPC1L 35
  • 75.8 (n)
  • 78.41 (a)
PABPC1L 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PABPC1L 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pabpc1l 35
  • 67.05 (n)
  • 75.91 (a)
zebrafish
(Danio rerio)
Actinopterygii pabpc1l 35
  • 67.89 (n)
  • 71.71 (a)
pabpc1l 36
  • 70 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR122C 35
  • 60.48 (n)
  • 55.24 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C17600g 35
  • 56.62 (n)
  • 56.27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAB1 35
  • 55.15 (n)
  • 54.5 (a)
PRP24 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PAB4 35
  • 51.31 (n)
  • 46.25 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04799 35
  • 57.34 (n)
  • 50.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pabp 35
  • 54.52 (n)
  • 53.14 (a)
Species with no ortholog for PABPC1L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PABPC1L Gene

ENSEMBL:
Gene Tree for PABPC1L (if available)
TreeFam:
Gene Tree for PABPC1L (if available)

Paralogs for PABPC1L Gene

genes like me logo Genes that share paralogs with PABPC1L: view

Variants for PABPC1L Gene

Sequence variations from dbSNP and Humsavar for PABPC1L Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs2075960 - 44,919,036(+) TCTTC(A/G/T)CCCAG reference, missense
rs6513956 - 44,935,420(+) GACCC(A/G)GTGGG reference, missense, utr-variant-3-prime
rs11780 -- 44,938,146(+) AACTC(A/G)GAGCT reference, synonymous-codon, utr-variant-3-prime
rs12031 -- 44,933,019(+) ACTCC(A/G)TCCAA intron-variant
rs12798 -- 44,933,013(+) CCCAC(C/T)ACTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PABPC1L Gene

Variant ID Type Subtype PubMed ID
nsv518547 CNV Gain 19592680

Variation tolerance for PABPC1L Gene

Residual Variation Intolerance Score: 73.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.86; 83.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PABPC1L Gene

HapMap Linkage Disequilibrium report
PABPC1L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPC1L Gene

Disorders for PABPC1L Gene

Relevant External Links for PABPC1L

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PABPC1L

No disorders were found for PABPC1L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PABPC1L Gene

Publications for PABPC1L Gene

  1. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4 67
  2. A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. (PMID: 11549316) Fossey S.C. … Bowden D.W. (Genomics 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells. (PMID: 24968937) Maldarelli F. … Hughes S.H. (Science 2014) 3
  5. HIV/AIDS. Persistence by proliferation? (PMID: 25013050) Margolis D. … Bushman F. (Science 2014) 3

Products for PABPC1L Gene

Sources for PABPC1L Gene

Back to Top

Content