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Aliases for PABPC1L Gene

Aliases for PABPC1L Gene

  • Poly(A) Binding Protein, Cytoplasmic 1-Like 2 3
  • C20orf119 3 4
  • Chromosome 20 Open Reading Frame 119 2
  • Polyadenylate-Binding Protein 1-Like 3
  • DJ1069P2.3 3
  • PABPC1L1 3
  • EPAB 3

External Ids for PABPC1L Gene

Previous Symbols for PABPC1L Gene

  • C20orf119

Summaries for PABPC1L Gene

GeneCards Summary for PABPC1L Gene

PABPC1L (Poly(A) Binding Protein, Cytoplasmic 1-Like) is a Protein Coding gene. Among its related pathways are RNA transport and Deadenylation-dependent mRNA decay. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is PABPC1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC1L Gene

Genomics for PABPC1L Gene

Genomic Location for PABPC1L Gene

Start:
44,910,060 bp from pter
End:
44,959,035 bp from pter
Size:
48,976 bases
Orientation:
Plus strand

Genomic View for PABPC1L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PABPC1L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC1L Gene

Regulatory Elements for PABPC1L Gene

Proteins for PABPC1L Gene

  • Protein details for PABPC1L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4VXU2-PAP1L_HUMAN
    Recommended name:
    Polyadenylate-binding protein 1-like
    Protein Accession:
    Q4VXU2
    Secondary Accessions:
    • Q4VY17

    Protein attributes for PABPC1L Gene

    Size:
    614 amino acids
    Molecular mass:
    68392 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PABPC1L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PABPC1L Gene

Proteomics data for PABPC1L Gene at MOPED

Post-translational modifications for PABPC1L Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys95, Lys284, Lys333, and Lys348

No data available for DME Specific Peptides for PABPC1L Gene

Domains for PABPC1L Gene

Gene Families for PABPC1L Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for PABPC1L Gene

UniProtKB/Swiss-Prot:

PAP1L_HUMAN
Domain:
  • Contains 1 PABC domain.:
    • Q4VXU2
  • Contains 4 RRM (RNA recognition motif) domains.:
    • Q4VXU2
Family:
  • Belongs to the polyadenylate-binding protein type-1 family.:
    • Q4VXU2
genes like me logo Genes that share domains with PABPC1L: view

Function for PABPC1L Gene

Gene Ontology (GO) - Molecular Function for PABPC1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with PABPC1L: view
genes like me logo Genes that share phenotypes with PABPC1L: view

Animal Models for PABPC1L Gene

MGI Knock Outs for PABPC1L:

miRNA for PABPC1L Gene

miRTarBase miRNAs that target PABPC1L

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PABPC1L Gene

Localization for PABPC1L Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PABPC1L Gene COMPARTMENTS Subcellular localization image for PABPC1L gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PABPC1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with PABPC1L: view

Pathways for PABPC1L Gene

genes like me logo Genes that share pathways with PABPC1L: view

Pathways by source for PABPC1L Gene

3 KEGG pathways for PABPC1L Gene

Interacting Proteins for PABPC1L Gene

Gene Ontology (GO) - Biological Process for PABPC1L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001556 oocyte maturation IEA --
GO:0006378 mRNA polyadenylation IEA --
genes like me logo Genes that share ontologies with PABPC1L: view

Transcripts for PABPC1L Gene

mRNA/cDNA for PABPC1L Gene

(7) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PABPC1L Gene

Poly(A) binding protein, cytoplasmic 1-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC1L Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10
SP1: - - -
SP2: - -
SP3: - -
SP4: - -
SP5:
SP6: -

Relevant External Links for PABPC1L Gene

GeneLoc Exon Structure for
PABPC1L
ECgene alternative splicing isoforms for
PABPC1L

Expression for PABPC1L Gene

mRNA expression in normal human tissues for PABPC1L Gene

mRNA differential expression in normal tissues according to GTEx for PABPC1L Gene

This gene is overexpressed in Liver (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PABPC1L Gene

SOURCE GeneReport for Unigene cluster for PABPC1L Gene Hs.641481

genes like me logo Genes that share expressions with PABPC1L: view

Orthologs for PABPC1L Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PABPC1L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PABPC1L 36
  • 99.57 (n)
  • 99.84 (a)
PABPC1L 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PABPC1L 36
  • 88.45 (n)
  • 88.78 (a)
PABPC1L 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PABPC1L 36
  • 88.14 (n)
  • 88.3 (a)
PABPC1L 37
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pabpc1l 36
  • 81.57 (n)
  • 78.73 (a)
Pabpc1l 16
Pabpc1l 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PABPC1L 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PABPC1L 37
  • 63 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Pabpc1l 36
  • 81.45 (n)
  • 78.9 (a)
chicken
(Gallus gallus)
Aves PABPC1L 36
  • 75.8 (n)
  • 78.41 (a)
PABPC1L 37
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PABPC1L 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pabpc1l 36
  • 67.05 (n)
  • 75.91 (a)
zebrafish
(Danio rerio)
Actinopterygii pabpc1l 36
  • 67.89 (n)
  • 71.71 (a)
pabpc1l 37
  • 70 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR122C 36
  • 60.48 (n)
  • 55.24 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PAB1 36
  • 55.15 (n)
  • 54.5 (a)
PRP24 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C17600g 36
  • 56.62 (n)
  • 56.27 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PAB4 36
  • 51.31 (n)
  • 46.25 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04799 36
  • 57.34 (n)
  • 50.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pabp 36
  • 54.52 (n)
  • 53.14 (a)
Species with no ortholog for PABPC1L:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PABPC1L Gene

ENSEMBL:
Gene Tree for PABPC1L (if available)
TreeFam:
Gene Tree for PABPC1L (if available)

Paralogs for PABPC1L Gene

genes like me logo Genes that share paralogs with PABPC1L: view

Variants for PABPC1L Gene

Sequence variations from dbSNP and Humsavar for PABPC1L Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs11780 -- 44,938,146(+) AACTC(A/G)GAGCT reference, synonymous-codon, nc-transcript-variant
rs12031 -- 44,933,019(+) ACTCC(A/G)TCCAA intron-variant
rs12798 -- 44,933,013(+) CCCAC(C/T)ACTCC intron-variant
rs1132864 -- 44,938,152(+) GAGCT(G/T)TTGCT reference, synonymous-codon, nc-transcript-variant
rs1998033 -- 44,930,268(-) TTAGC(A/G)AGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PABPC1L Gene

Variant ID Type Subtype PubMed ID
nsv518547 CNV Gain 19592680

Relevant External Links for PABPC1L Gene

HapMap Linkage Disequilibrium report
PABPC1L

Disorders for PABPC1L Gene

No disorders were found for PABPC1L Gene.

No data available for UniProtKB/Swiss-Prot for PABPC1L Gene

Publications for PABPC1L Gene

  1. A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20. (PMID: 11549316) Fossey S.C. … Bowden D.W. (Genomics 2001) 2 3
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. Isolation of the human ePAB and ePABP2 cDNAs and analysis of the expression patterns. (PMID: 18483763) Sakugawa N. … Sengoku K. (J. Assist. Reprod. Genet. 2008) 3

Products for PABPC1L Gene

Sources for PABPC1L Gene

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