PABPC1 Gene
protein-coding GIFtS: 61
GCID: GC08M101715
|
|
poly(A) binding protein, cytoplasmic 1(Previous names: poly(A)-binding protein, cytoplasmic 2 )
(Previous symbols: PAB1, PABPC2)
| |
Aliases
for PABPC1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Poly(A) Binding Protein, Cytoplasmic 11 2 | | Poly(A)-Binding Protein, Cytoplasmic 21 | | PAB11 2 3 5 | | Poly(A) Binding Protein, Cytoplasmic 22 | | PABP11 2 3 5 | | Polyadenylate-Binding Protein 12 | | PABPC21 2 3 | | PABP-13 | | PABPL11 2 | | Poly(A)-Binding Protein 13 | | PABP2 5 | | |
Export aliases for PABPC1 gene to outside databasesPrevious GC identifers: GC08M100720 GC08M101785 GC08M101383 GC08M101671 GC08M101784 GC08M096913 |
Summaries
for PABPC1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PABPC1:
This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3'poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotesribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step inmRNA decay. The gene is part of a small gene family including three protein-coding genes and severalpseudogenes.(provided by RefSeq, Aug 2010)
UniProtKB/Swiss-Prot: PABP1_HUMAN, P11940Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism suchas pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressedby PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationallycoupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational anddecay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involvedin regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition ofpremature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with theribosome-bound release factors is proposed
Gene Wiki entry for PABPC1
|
Genomic Views
for PABPC1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000008.10 NC_018919.1 NT_008046.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PABPC1 gene promoter:
TBP Elk-1 Pax-5 Brachyury AP-2gamma E47 HFH-1 AP-2beta AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for PABPC1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PABPC1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 8q22.2-q23 Ensembl cytogenetic band: 8q22.3 HGNC cytogenetic band: 8q22.2-q23PABPC1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 8 GeneLoc Exon Structure GeneLoc location for GC08M101715: view genomic region
(about GC identifiers)
Start:
|
101,698,044 bp from pter |
End:
|
101,735,037 bp from pter |
Size:
|
36,994 bases |
Orientation:
|
minus strand |
|
Proteins
for PABPC1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: PABP1_HUMAN, P11940 (See
protein sequence)Recommended Name: Polyadenylate-binding protein 1 Size: 636 amino acids; 70671 Da
Subunit: Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1,PABPC1 and CSDE1. Interacts with IGF2BP1. Part of a complex associated with the FOS mCRD domain and consisting ofHNRPD, SYNCRIP, PAIP1 and CSDE1/UNR. Interacts with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1 andPAIP2. Interacts with PAIP1 with a 1:1 stoichiometry and with PAIP2 with a 1:2 stoichiometry. The interaction withCSDE1 is direct and RNA-independent. Found in a mRNP complex with YBX2. Interacts with PAPD4/GLD2. Identified in thespliceosome C complex. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3,PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed of ACTB,ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3,NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslatedmRNAs. Interacts with IGF2BP1 and NFX1. Interacts with PIWIL1 (By similarity). Interacts with EIF2C1, EIF2C2, GSPT1and GSPT2. Interacts with human cytomegalovirus/HHV-5 protein UL69. Interacts with LARP4B
Subcellular location: Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.Shuttles between the cytoplasm and the nucleus
Miscellaneous: Many viruses shutoff host mRNA translational machinery by inhibiting cellular PABPC1 activity usingdifferent mechanisms. Picornaviruses, caliciviruses or lentiviruses encode proteases that cleave PABPC1 at severaldefined sites in the proline-rich linker region between RRMs and the C-terminal domain. Rotaviruses, gammherpesvirusesand bunyamwera virus relocalize PABPC1 from the cytoplasm to the nucleus thus altering its function. Many of theseviruses translate their mRNA in a PABPC1-independent manner and are unaffected by host PABPC1 inhibition
Caution: Was termed (Ref.5) polyadenylate binding protein II
6/20 PDB 3D structures from  and Proteopedia  for PABPC1 (see all 20):1CVJ (3D)
1G9L (3D)
1JGN (3D)
1JH4 (3D)
2K8G (3D)
2RQG (3D)
Secondary accessions: Q15097 Q93004Alternative splicing: 2 isoforms: P11940-1 P11940-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for PABPC1: NX_P11940
Post-translational modifications:
Phosphorylated by MAPKAPK21
Methylated by CARM1. Arg-493 is dimethylated, probably to asymmetric dimethylarginine1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P11940
PABPC1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_002559.2
ENSEMBL proteins: ENSP00000430716 ENSP00000428021 ENSP00000313007 ENSP00000429594 ENSP00000429395 ENSP00000428948 ENSP00000428030 ENSP00000428840 ENSP00000428190 ENSP00000430068 ENSP00000427805 ENSP00000427914 ENSP00000429892 ENSP00000430159 ENSP00000429119 ENSP00000430012 ENSP00000429790 ENSP00000428937 ENSP00000428749 ENSP00000429032 Reactome Protein details: P11940
Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
PABPC1 for ontologies About GeneDecksing
PABPC1 Antibody Products:
Assay Products for PABPC1: |
Protein
Domains /
Families
for PABPC1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PABPC1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P11940ProtoNet protein and cluster: P11940 2 Blocks protein families: IPB000504 RNA-binding region RNP-1 (RNA recognition motif) IPB002004 Polyadenylate-binding protein/HECT-associated
UniProtKB/Swiss-Prot: PABP1_HUMAN, P11940Domain: The RNA-binding domains RRM1 and RRM2 and the C-terminus (last 138 amino acids) regions interact with thePABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1, respectivelyDomain: The RNA-binding domains RRM2 and RRM3 and the C-terminus (last 138 amino acids) regions interact with thePABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP2, respectivelySimilarity: Belongs to the polyadenylate-binding protein type-1 familySimilarity: Contains 1 PABC domainSimilarity: Contains 4 RRM (RNA recognition motif) domains |
Function
for PABPC1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: PABP1_HUMAN, P11940Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism suchas pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressedby PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationallycoupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational anddecay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involvedin regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition ofpremature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with theribosome-bound release factors is proposed Genatlas biochemistry entry for PABPC1:poly (A) binding protein,cytoplasmic 1,ubiquitously expressed,major cytoplasmic RNA-binding protein,70kDA,with asplicing variant (38kDa),involved in the regulation of translation initiation,mRNA stability,regulation of poly(A)tail length,translationally controlled through a cis-regulatory element composed of a cytidine residue at the cap sitefollowed by an interrupted stretch ol pyrimidines (5' - TOP motif)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PABPC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PABPC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for PABPC1 | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PABPC1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PABPC1 |
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
PABPC1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for PABPC1:
|
Pathways & Interactions
for PABPC1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Synthesis of PB1-F2 | | | 2 | Deadenylation-dependent mRNA decay | | | 3 | Metabolism of mRNA | | | 4 | Translation initiation complex formation | | | 5 | Ubiquitinated Orc1 is degraded by the proteasome | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for PABPC1
1 
Cell Signaling Technology (CST) Pathway for PABPC1
1  BioSystems Pathway for PABPC1
5/22 
Reactome Pathways for PABPC1 (see all 22)
3 
Kegg Pathways (Kegg details for PABPC1):
PABPC1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PABPC1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/967 Interacting proteins for PABPC1 (P119401, 2, 3 ENSP000003130074) via UniProtKB, MINT, STRING, and/or I2D (see all 967)About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
TAS | -- | | GO:0000288 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
TAS | -- | | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening |
TAS | -- | | GO:0000398 | mRNA splicing, via spliceosome |
IC | 11991638 | | GO:0006378 | mRNA polyadenylation |
TAS | 2885805 |
PABPC1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PABPC1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
PABPC1 for compounds About GeneDecksing
 Browse Tocris compounds for PABPC1
2 Novoseek chemical compound relationships for PABPC1 gene About this table
Search CenterWatch for drugs/clinical trials and news about PABPC1 / PABP1
|
Transcripts
for PABPC1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for PABPC1 gene: NM_002568.3 Unigene Cluster for PABPC1: Poly(A) binding protein, cytoplasmic 1 Hs.387804 [show with all ESTs]Unigene Representative Sequence: NM_00256818/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23): ENST00000518293 ENST00000520868 ENST00000318607(uc003yju.2 uc011lhc.1 uc003yjs.1 uc011lhd.1 uc003yjt.1)
ENST00000519004 ENST00000522387 ENST00000523636 ENST00000517990 ENST00000522658
ENST00000519848 ENST00000517403 ENST00000519596 ENST00000518716 ENST00000519622
ENST00000519100 ENST00000517921 ENST00000523555 ENST00000518196 ENST00000521865
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PABPC1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PABPC1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for PABPC1 | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for PABPC1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PABPC1 |
Additional cDNA sequence: AK057080.1 AK130523.1 AK298990.1 AK303120.1 BC015958.2 BC023217.1 BC023520.2 Y00345.1 Z48501.1 24/120 DOTS entries (see all 120): DT.95267608 DT.100700601 DT.92470838 DT.92470903 DT.92470896 DT.100700595 DT.121466365 DT.100700590 DT.91954612 DT.95267607 DT.91870787 DT.100043224 DT.95267689 DT.92359426 DT.97869208 DT.91661782 DT.100852698 DT.121466401 DT.100700596 DT.91801712 DT.100700594 DT.91800129 DT.95267673 DT.91847189 24/2559 AceView cDNA sequences (see all 2559): BM915967 CA334985 BM802601 BM475752 AA382633 AA860067 BU508576 BQ084301 BQ775300 CA446268 AI755004 BI870510 CB161919 BM474996 F07481 BM823460 CB120256 BI861286 BQ424443 F02746 BQ437127 BM467934 BM786815 BU683070
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PABPC1 (see all 12) About this scheme
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 12c | ^ | 13a | · | 13b | ^ | 14 |
|---|
|
| SP1: | | | | | | | | | |
| SP2: | | | | | | | | | |
| SP3: | | | | | | | | | |
| SP4: | | | | | | | | | |
| SP5: | | | | | | | | |
ECgene alternative splicing isoforms for PABPC1
|
Expression
for PABPC1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| PABPC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAAGAAACT
About this image
See PABPC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for PABPC1
SOURCE GeneReport for Unigene cluster: Hs.387804
UniProtKB/Swiss-Prot: PABP1_HUMAN, P11940Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Array including PABPC1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PABPC1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat PABPC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PABPC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PABPC1 |
Orthologs
for PABPC1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for PABPC1 gene from 9/38 species (see all 38) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
PABPC11 |
poly(A) binding protein, cytoplasmic 1 |
88.1(n)
97.96(a) |
|
430997 NM_001031597.1 NP_001026768.1 |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
98(a) |
1 → many |
GL343394.1(21981-39533) |
African clawed frog
(Xenopus laevis) |
Amphibia |
pabpc1-prov2 |
poly(A) binding protein, cytoplasmic 1 |
81.77(n) |
|
M27072.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
pabpc12 |
poly A binding protein, cytoplasmic 1 |
78.97(n) |
|
324517 BC059662.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
pAbp3 |
RNA binding |
57(a)
(best of 2) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
pab-23 |
RNA recognition motif. (aka RRM, RBD, or RNP
domain) more |
60(a)
(best of 2) |
|
X(13557928-13561043) -- |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
MIP6(YHR015W)4
PAB11 |
Putative RNA-binding protein, interacts with Mex67p, more4
Pab1p1 |
57.73(n)1
57.18(a)1 |
|
8(134554-136533)4
8569121 NP_011092.11 8564084
NP_011879.14 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
PAB81 |
poly(A) binding protein 8 |
55.84(n)
52.38(a) |
|
841399 NM_001198255.1 NP_001185184.1 |
rice
(Oryza sativa) |
Liliopsida |
Os08g03148001 |
hypothetical protein |
54.79(n)
50.59(a) |
|
4345242 NM_001068050.1 NP_001061515.1 |
ENSEMBL Gene Tree for PABPC1 (if available)
TreeFam Gene Tree for PABPC1 (if available) |
Paralogs
for PABPC1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for PABPC1 gene
- PABPC1L2 PABPC52 PABPC42 PABPC4L2 ELAVL12 RBMS12 ELAVL42 ELAVL32
- RBMS32 PABPC32 ELAVL22 PABPC1L2B2 PABPC1L2A2 PUF602 RBMS22
18/31 SIMAP similar genes for PABPC1 using alignment to 20 protein entries: PABP1_HUMAN (see all proteins)
(see all similar genes):PABPC3 PABPC1L2A PABPC1L2B PABPC4L PABPC4 PABPC5
PABPC1L UBR5 RBFOX1 BOLL ELAVL2 RBM7
RBMY1A1 RBMY1C RBMY1E U2SURP RBMY1J HNRNPA1
PABPC1 for paralogs About GeneDecksing
5/13 Pseudogenes.org Pseudogenes for PABPC1 (see all 13)
PGOHUM00000238427 PGOHUM00000238742 PGOHUM00000239830 PGOHUM00000247279 PGOHUM00000256774
|
Genomic Variants
for PABPC1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 8 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for PABPC1 (101698044 - 101735037 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for PABPC1
1 CNV: 44322
1 Indel: 41111
Human Gene Mutation Database (HGMD): PABPC1
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PABPC1 |
|
Disorders
/ Diseases
for PABPC1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PABPC1 for disorders About GeneDecksing
OMIM gene information: 604679
OMIM disorders: --
18  diseases for PABPC1: About MalaCardsmyotonic dystrophy cytomegalovirus infection motor neuron disease herpes simplex
kaposi's sarcoma rubella neurodegeneration sarcoma
hepatocellular carcinoma esophageal cancer esophagitis influenza
immunodeficiency prostate cancer prostatitis neuronitis
carcinoma malaria
5 Novoseek disease relationships for PABPC1 gene About this table
Export disorders for PABPC1 gene to outside databases
|
Publications
for PABPC1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for PABPC1 gene, integrated from 9 sources (see all 245):
(articles sorted by number of sources associating them with PABPC1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif. (PubMed id 2885805)1, 2, 3 Grange T.... Pictet R. (1987)
- The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm. (PubMed id 9582337)1, 2, 9 Afonina E.... Pavlakis G.N. (1998)
- Dual interactions of the translational repressor Paip2 with poly(A) binding protein. (PubMed id 11438674)1, 2, 9 Khaleghpour K.... Sonenberg N. (2001)
- Paip1 interacts with poly(A) binding protein through two independent binding motifs. (PubMed id 11997512)1, 2, 9 Roy G.... Sonenberg N. (2002)
- Translational repression by a novel partner of human poly(A) binding protein, Paip2. (PubMed id 11172725)1, 2, 9 Khaleghpour K.... Sonenberg N. (2001)
- Molecular determinants of PAM2 recognition by the MLL E domain of poly(A)-binding protein. (PubMed id 20096703)1, 2, 9 Kozlov G....Gehring K. (2010)
- A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. (PubMed id 18447585)1, 2, 9 Singh G....Lykke-Andersen J. (2008)
- PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. (PubMed id 11850402)1, 2, 9 Lee J. and Bedford M.T. (2002)
- The mRNA poly(A)-binding protein: localization, abundance, and RNA- binding specificity. (PubMed id 7908267)1, 2, 9 Goerlach M.... Dreyfuss G. (1994)
- Recognition of polyadenylate RNA by the poly(A)-binding protein. (PubMed id 10499800)1, 2, 9 Deo R.C.... Burley S.K. (1999)
|
External Searches for PABPC1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PABPC1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PABPC1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PABPC1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for PABPC1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for PABPC1 gene:
Search GeneIP for patents involving PABPC1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PABPC1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for PABPC1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for PABPC1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for PABPC1 | | | OriGene Protein Over-expression Lysate for PABPC1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for PABPC1 | | OriGene 3'-UTR Clone for PABPC1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for PABPC1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for PABPC1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for PABPC1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for PABPC1 | | OriGene Custom Protein Services for PABPC1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat PABPC1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing PABPC1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat PABPC1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat PABPC1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat PABPC1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat PABPC1 |
| |
 |  |  |  | |
| | Antibodies & Assays for PABPC1
(PABP 1) |
| | | | Search Tocris compounds for PABPC1 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | PABPC1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | ThermoFisher Antibodies for PABPC1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat PABPC1 |
|
|
|
|
