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PABPC1 Gene

protein-coding   GIFtS: 63
GCID: GC08M101715

Poly(A) Binding Protein, Cytoplasmic 1

(Previous names: poly(A)-binding protein, cytoplasmic 2)
(Previous symbols: PAB1, PABPC2)
  See PABPC1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Poly(A) Binding Protein, Cytoplasmic 11 2     PABPL12
PAB11 2 3 5     Poly(A) Binding Protein, Cytoplasmic 22
PABPC21 2 3     Polyadenylate-Binding Protein 12
PABP12 3 5     PABP-13
PABP2 5     Poly(A)-Binding Protein 13
Poly(A)-Binding Protein, Cytoplasmic 21     

External Ids:    HGNC: 85541   Entrez Gene: 269862   Ensembl: ENSG000000707567   OMIM: 6046795   UniProtKB: P119403   

Export aliases for PABPC1 gene to outside databases

Previous GC identifers: GC08M100720 GC08M101785 GC08M101383 GC08M101671 GC08M101784 GC08M096913


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PABPC1 Gene:
This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to
the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to
poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening
which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding
genes and several pseudogenes.(provided by RefSeq, Aug 2010)

GeneCards Summary for PABPC1 Gene:
PABPC1 (poly(A) binding protein, cytoplasmic 1) is a protein-coding gene. Diseases associated with PABPC1 include rift valley fever. GO annotations related to this gene include poly(A) binding and nucleotide binding. An important paralog of this gene is PABPC1L.

UniProtKB/Swiss-Prot: PABP1_HUMAN, P11940
Function: Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic
regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation
regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences
other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding
proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major
coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD)
of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and
initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is
proposed

Gene Wiki entry for PABPC1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the PABPC1 gene promoter:
         TBP   Elk-1   Pax-5   Brachyury   AP-2gamma   E47   HFH-1   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidPABPC1 promoter sequence
   Search Chromatin IP Primers for PABPC1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PABPC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.2-q23   Ensembl cytogenetic band:  8q22.3   HGNC cytogenetic band: 8q22.2-q23

PABPC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PABPC1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M101715:  view genomic region     (about GC identifiers)

Start:
101,698,044 bp from pter      End:
101,735,037 bp from pter
Size:
36,994 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: PABP1_HUMAN, P11940 (See protein sequence)
Recommended Name: Polyadenylate-binding protein 1  
Size: 636 amino acids; 70671 Da
Subunit: May form homodimers. Component of a multisubunit autoregulatory ribonucleoprotein complex (ARC), at least
composed of IGF2BP1, PABPC1 and CSDE1. Directly interacts with IGF2BP1. Part of a complex associated with the FOS
mCRD domain and consisting of HNRPD, SYNCRIP, PAIP1 and CSDE1/UNR. Interacts with the PABPC1-interacting motif-1
(PAM1) and -2 (PAM2) of PAIP1 and PAIP2. Interacts with PAIP1 with a 1:1 stoichiometry and with PAIP2 with a 1:2
stoichiometry. The interaction with CSDE1 is direct and RNA-independent. Found in a mRNP complex with YBX2.
Interacts with PAPD4/GLD2. Identified in the spliceosome C complex. Identified in a mRNP complex, at least
composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1.
Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with NFX1.
Interacts with PIWIL1. Interacts with AGO1, AGO2, GSPT1 and GSPT2. Interacts with human cytomegalovirus/HHV-5
protein UL69. Interacts with LARP4B
Miscellaneous: Many viruses shutoff host mRNA translational machinery by inhibiting cellular PABPC1 activity using
different mechanisms. Picornaviruses, caliciviruses or lentiviruses encode proteases that cleave PABPC1 at
several defined sites in the proline-rich linker region between RRMs and the C-terminal domain. Rotaviruses,
gammherpesviruses and bunyamwera virus relocalize PABPC1 from the cytoplasm to the nucleus thus altering its
function. Many of these viruses translate their mRNA in a PABPC1-independent manner and are unaffected by host
PABPC1 inhibition
Caution: Was termed (Ref.5) polyadenylate binding protein II
Selected PDB 3D structures from and Proteopedia for PABPC1 (see all 20):
1CVJ (3D)        1G9L (3D)        1JGN (3D)        1JH4 (3D)        2K8G (3D)        2RQG (3D)    
Secondary accessions: Q15097 Q93004
Alternative splicing: 2 isoforms:  P11940-1   P11940-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for PABPC1: NX_P11940

Explore proteomics data for PABPC1 at MOPED

Post-translational modifications: 

  • Phosphorylated by MAPKAPK21
  • Methylated by CARM1. Arg-493 is dimethylated, probably to asymmetric dimethylarginine1
  • Ubiquitination2 at Lys78, Lys95, Lys104, Lys108, Lys113, Lys129, Lys138, Lys157, Lys188, Lys196,
                                 Lys208, Lys213, Lys231, Lys259, Lys284, Lys299, Lys312, Lys333, Lys348, Lys361 (see all 23)
  • Modification sites at PhosphoSitePlus

  • See PABPC1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002559.2  
    ENSEMBL proteins: 
     ENSP00000430716   ENSP00000428021   ENSP00000313007   ENSP00000429594   ENSP00000429395  
     ENSP00000428948   ENSP00000428030   ENSP00000428840   ENSP00000428190   ENSP00000427805  
     ENSP00000427914   ENSP00000429892   ENSP00000430159   ENSP00000429119   ENSP00000430012  
     ENSP00000429790   ENSP00000428937   ENSP00000428749   ENSP00000429032  
    Reactome Protein details: P11940

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    4 InterPro protein domains:
     IPR002004 PABP_HYD
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom
     IPR006515 PABP_1234

    Graphical View of Domain Structure for InterPro Entry P11940

    ProtoNet protein and cluster: P11940

    2 Blocks protein domains:
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB002004 Polyadenylate-binding protein/HECT-associated


    UniProtKB/Swiss-Prot: PABP1_HUMAN, P11940
    Domain: The RNA-binding domains RRM1 and RRM2 and the C-terminus (last 138 amino acids) regions interact with the
    PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1, respectively
    Domain: The RNA-binding domains RRM2 and RRM3 and the C-terminus (last 138 amino acids) regions interact with the
    PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP2, respectively
    Similarity: Belongs to the polyadenylate-binding protein type-1 family
    Similarity: Contains 1 PABC domain
    Similarity: Contains 4 RRM (RNA recognition motif) domains


    Find genes that share domains with PABPC1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PABP1_HUMAN, P11940
    Function: Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic
    regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation
    regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences
    other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding
    proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major
    coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD)
    of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and
    initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is
    proposed

         Genatlas biochemistry entry for PABPC1:
    poly (A) binding protein,cytoplasmic 1,ubiquitously expressed,major cytoplasmic RNA-binding protein,70kDA,with a
    splicing variant (38kDa),involved in the regulation of translation initiation,mRNA stability,regulation of
    poly(A) tail length,translationally controlled through a cis-regulatory element composed of a cytidine residue at
    the cap site followed by an interrupted stretch ol pyrimidines (5' - TOP motif)

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI11172725
    GO:0008022protein C-terminus binding IPI15663938
         
    Find genes that share ontologies with PABPC1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for PABPC1:
     Nucleolar pre-40S maturation d 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for PABPC1

    miRNA
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    miRTarBase miRNAs that target PABPC1:
    hsa-mir-10a-5p (MIRT047745), hsa-mir-193b-3p (MIRT041210), hsa-mir-149-5p (MIRT045519), hsa-mir-423-5p (MIRT038147), hsa-mir-423-3p (MIRT042479), hsa-mir-744-5p (MIRT037728), hsa-mir-1295a (MIRT035902), hsa-let-7b-5p (MIRT052261), hsa-mir-18a-3p (MIRT040841), hsa-mir-30a-5p (MIRT028502), hsa-mir-181a-5p (MIRT047328), hsa-mir-125b-5p (MIRT004993), hsa-mir-10b-5p (MIRT047501)

    Block miRNA regulation of human, mouse, rat PABPC1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate PABPC1 (see all 24):
    hsa-miR-502-5p hsa-miR-4307 hsa-miR-520d-5p hsa-miR-374a hsa-miR-3133 hsa-miR-507 hsa-miR-3692 hsa-miR-186
    SwitchGear 3'UTR luciferase reporter plasmidPABPC1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PABP1_HUMAN, P11940: Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated
    mRNAs. Shuttles between the cytoplasm and the nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4
    cytoskeleton1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm TAS9582337
    GO:0005829cytosol TAS--
    GO:0010494cytoplasmic stress granule IDA--
    GO:0030529ribonucleoprotein complex IDA17289661

    Find genes that share ontologies with PABPC1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PABPC1 About   (see all 12)  
    See pathways by source

    SuperPathContained pathways About
    1Deadenylation-dependent mRNA decay
    Deadenylation-dependent mRNA decay0.48
    Deadenylation of mRNA0.48
    RNA degradation0.48
    2Influenza Viral RNA Transcription and Replication
    Nonsense Mediated Decay Independent of the Exon Junction Complex0.94
    Nonsense-Mediated Decay0.89
    L13a-mediated translational silencing of Ceruloplasmin expression0.94
    Nonsense Mediated Decay Enhanced by the Exon Junction Complex0.89
    Cap-dependent Translation Initiation0.89
    Translation0.82
    Eukaryotic Translation Initiation0.89
    3Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
    Translation initiation complex formation0.91
    Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S0.90
    4CDK-mediated phosphorylation and removal of Cdc6
    Destabilization of mRNA by AUF1 (hnRNP D0)0.88
    Regulation of mRNA Stability by Proteins that Bind AU-rich Elements0.62
    5Apoptotic Pathways in Synovial Fibroblasts
    eIF2 Pathway0.60


    Find genes that share SuperPaths with PABPC1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for PABPC1
        eIF2 Pathway
    Regulation of eIF4 and p70S6K

    1 Cell Signaling Technology (CST) Pathway for PABPC1
        Translational Control

    1 BioSystems Pathway for PABPC1
        Translation Factors


    Selected Reactome Pathways for PABPC1 (see all 6)
        Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
    Deadenylation of mRNA
    L13a-mediated translational silencing of Ceruloplasmin expression
    AUF1 (hnRNP D0) destabilizes mRNA
    Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


    3 Kegg Pathways  (Kegg details for PABPC1):
        RNA transport
    mRNA surveillance pathway
    RNA degradation

        Pathway & Disease-focused RT2 Profiler PCR Array including PABPC1: 
              PI3K-AKT Signaling Pathway in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for PABPC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PABPC1 (P119401, 2, 3 ENSP000003130074) via UniProtKB, MINT, STRING, and/or I2D (see all 1078)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000184nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS--
    GO:0000288nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS--
    GO:0000289nuclear-transcribed mRNA poly(A) tail shortening TAS--
    GO:0000398mRNA splicing, via spliceosome IC11991638
    GO:0006378mRNA polyadenylation TAS2885805

    Find genes that share ontologies with PABPC1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    2 Novoseek inferred chemical compound relationships for PABPC1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pabc 88.3 4 20418951 (1), 14685257 (1), 20098421 (1), 20096703 (1)
    adenylate 79.7 132 9245750 (6), 16834569 (5), 9195926 (4), 12952955 (4) (see all 52)



    Find genes that share compounds with PABPC1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for PABPC1 gene: 
    NM_002568.3  

    Unigene Cluster for PABPC1:

    Poly(A) binding protein, cytoplasmic 1
    Hs.387804  [show with all ESTs]
    Unigene Representative Sequence: NM_002568
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
    ENST00000518293 ENST00000520868 ENST00000318607(uc003yju.2 uc011lhc.1 uc003yjs.1 uc011lhd.1 uc003yjt.1)
    ENST00000519004 ENST00000522387 ENST00000523636 ENST00000517990 ENST00000522658
    ENST00000519848 ENST00000517403 ENST00000519596 ENST00000518716 ENST00000519622
    ENST00000519100 ENST00000517921 ENST00000523555 ENST00000518196 ENST00000521865

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    Additional mRNA sequence: 

    AK057080.1 AK130523.1 AK298990.1 AK303120.1 BC015958.2 BC023217.1 BC023520.2 Y00345.1 
    Z48501.1 

    Selected DOTS entries (see all 118):

    DT.95267608  DT.100700601  DT.92470838  DT.92470903  DT.92470896  DT.100700595  DT.121466365  DT.100700590 
    DT.91954612  DT.95267607  DT.91870787  DT.100043224  DT.95267689  DT.92359426  DT.97869208  DT.91661782 
    DT.121466401  DT.100852698  DT.100700596  DT.100700594  DT.91800129  DT.95267673  DT.91801712  DT.91847189 

    Selected AceView cDNA sequences (see all 2559):

    AI888636 BM668412 AA328751 BM693020 BU735422 AI753344 BE301772 BM462819 
    BU169615 BG284427 AA908460 BU737971 BM511956 BM998176 BG286918 AA676275 
    BM554286 BG291180 BU153312 CB135079 CB136177 BQ225994 BM825258 BG390566 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for PABPC1 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ·
    SP1:                                                                          -                                                                                 
    SP2:                                                                          -                       -                                                         
    SP3:                                                              -     -     -                                                                                 
    SP4:                                                                          -                       -                                                         
    SP5:                    -     -     -     -     -                             -                                                                                 

    ExUns: 12c ^ 13a · 13b ^ 14
    SP1:                        
    SP2:                        
    SP3:                        
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for PABPC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    PABPC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAAAGAAACT
    PABPC1 Expression
    About this image


    PABPC1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)
             Oviduct
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    PABPC1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PABPC1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.387804

    UniProtKB/Swiss-Prot: PABP1_HUMAN, P11940
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including PABPC1: 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PABPC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PABPC1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pabpc11 , 5 poly(A) binding protein, cytoplasmic 11, 5 95.18(n)1
    99.69(a)1
      15 (14.51 cM)5
    184581  NM_008774.31  NP_032800.21 
     365956615 
    chicken
    (Gallus gallus)
    Aves PABPC11 poly(A) binding protein, cytoplasmic 1 88.1(n)
    97.96(a)
      430997  NM_001031597.1  NP_001026768.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    93(a)
    1 → many
    GL343394.1(21981-42069)
    African clawed frog
    (Xenopus laevis)
    Amphibia pabpc1-prov2 poly(A) binding protein, cytoplasmic 1 81.77(n)    M27072.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pabpc12 poly A binding protein, cytoplasmic 1 78.97(n)   324517  BC059662.1 
    worm
    (Caenorhabditis elegans)
    Secernentea pab-23
    pab-11
    RNA recognition motif. (aka RRM, RBD,
    or RNP domain) more3
    pab-11
    60(a)
    (best of 2)3
    58.99(n)1
    59.83(a)1
      X(13557928-13561043)3
    1729201  NM_001026538.41  NP_001021709.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PAB81 PAB8 54.76(n)
    51.87(a)
      841399  NM_103863.2  NP_564554.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g03148001 Os08g0314800 55.11(n)
    51.01(a)
      4345242  NM_001068050.1  NP_001061515.1 


    ENSEMBL Gene Tree for PABPC1 (if available)
    TreeFam Gene Tree for PABPC1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PABPC1 gene
    PABPC1L2  PABPC52  PABPC42  ELAVL12  PABPC4L2  ELAVL42  RBMS12  ELAVL32  
    RBMS32  PABPC32  ELAVL22  RBMS22  
    Selected SIMAP similar genes for PABPC1 using alignment to 19 protein entries:     PABP1_HUMAN (see all proteins) (see all similar genes):
    RLIM    PABPC3    PABPC1L2A    PABPC1L2B    PABPC4L    PABPC4
    PABPC5    UBR5    PABPC1L    RBFOX1    BOLL    ELAVL2
    RBM7    RBMY1A1    RBMY1C    RBMY1E    U2SURP    RBMY1J

    Find genes that share paralogs with PABPC1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for PABPC1 (see all 13)
    PGOHUM00000238427 PGOHUM00000238742 PGOHUM00000239830 PGOHUM00000247279 PGOHUM00000256774


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PABPC1 (see all 637)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429854611,2
    C,Funtested1102008460(+) GGCTTC/ATTCTG 2 /E /* stg11Minor allele frequency- A:0.16EU 283
    rs341166241,2
    C--96914999(+) TCTCA-/A/AA  
            
    AAAAA
    1 -- int10--------
    rs681686581,2
    C,F--96923755(+) AAAAA-/AA/GA 
            
    AAAAA
    1 -- int12NA CSA 4
    rs342750301,2
    C--96924873(+) AAAAAA/-TTCTT 1 -- int12Minor allele frequency- -:0.00NA CSA 4
    rs1419962101,2
    C--96926096(+) CACAC-/ACACAC
    ACACACAT
    ATATA
    1 -- int10--------
    rs31335281,2
    C,F--96926109(+) ACACAT/CATATA 1 -- int14Minor allele frequency- C:0.43NA WA CSA 7
    rs576345161,2
    C--96926117(+) ATATAC/TCTCCA 1 -- int12Minor allele frequency- T:0.33WA CSA 3
    rs347951391,2
    C--96930339(+) CCTAG-/TTTTTTT 1 -- int10--------
    rs1471426961,2
    --96935019(+) GGTGAA/GTACAT 1 -- us2k10--------
    rs1125534971,2
    C,F--101716183(+) GAGGCT/CGAGGC 1 -- int11Minor allele frequency- C:0.00CSA 1

    HapMap Linkage Disequilibrium report for PABPC1 (101698044 - 101735037 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for PABPC1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2050419CNV Deletion18987734
    esv2737364CNV Deletion23290073
    esv2737361CNV Deletion23290073
    esv2737360CNV Deletion23290073
    esv2737365CNV Deletion23290073
    nsv824694CNV Gain20364138

    Human Gene Mutation Database (HGMD): PABPC1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PABPC1
    DNA2.0 Custom Variant and Variant Library Synthesis for PABPC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604679    OMIM disorders: --

    1 disease for PABPC1:    
    About MalaCards
    rift valley fever


    Find genes that share disorders with PABPC1           About GenesLikeMe

    5 Novoseek inferred disease relationships for PABPC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    erythroleukemia 21.2 1 10373504 (1)
    neurodegeneration 7.15 1 18271626 (1)
    tumors 2.24 2 15353001 (1), 20096703 (1)
    shock 0 9 19087191 (4), 20221403 (2), 10477262 (1)
    immunodeficiency 0 2 16594896 (1), 19956697 (1)


    Export disorders for PABPC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for PABPC1 gene, integrated from 10 sources (see all 275):
    (articles sorted by number of sources associating them with PABPC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif. (PubMed id 2885805)1, 2, 3 Grange T.... Pictet R. (Nucleic Acids Res. 1987)
    2. The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm. (PubMed id 9582337)1, 2, 9 Afonina E.... Pavlakis G.N. (J. Biol. Chem. 1998)
    3. IMP1 interacts with poly(A)-binding protein (PABP) and the autoregulatory translational control element of PABP-mRNA through the KH III-IV domain. (PubMed id 17212783)1, 2, 9 Patel G.P. and Bag J. (FEBS J. 2006)
    4. Dual interactions of the translational repressor Paip2 with poly(A) binding protein. (PubMed id 11438674)1, 2, 9 Khaleghpour K.... Sonenberg N. (Mol. Cell. Biol. 2001)
    5. Paip1 interacts with poly(A) binding protein through two independent binding motifs. (PubMed id 11997512)1, 2, 9 Roy G.... Sonenberg N. (Mol. Cell. Biol. 2002)
    6. Translational repression by a novel partner of human poly(A) binding protein, Paip2. (PubMed id 11172725)1, 2, 9 Khaleghpour K.... Sonenberg N. (Mol. Cell 2001)
    7. Molecular determinants of PAM2 recognition by the MLLE domain of poly(A)-binding protein. (PubMed id 20096703)1, 2, 9 Kozlov G.... Gehring K. (J. Mol. Biol. 2010)
    8. A competition between stimulators and antagonists of Upf complex recruitment governs human nonsense-mediated mRNA decay. (PubMed id 18447585)1, 2, 9 Singh G.... Lykke-Andersen J. (PLoS Biol. 2008)
    9. PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. (PubMed id 11850402)1, 2, 9 Lee J. and Bedford M.T. (EMBO Rep. 2002)
    10. The mRNA poly(A)-binding protein: localization, abundance, and RNA- binding specificity. (PubMed id 7908267)1, 2, 9 Goerlach M.... Dreyfuss G. (Exp. Cell Res. 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 26986 HGNC: 8554 AceView: PABPC1 Ensembl:ENSG00000070756 euGenes: HUgn26986
    ECgene: PABPC1 Kegg: 26986 H-InvDB: PABPC1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PABPC1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PABPC1 gene:
    Search GeneIP for patents involving PABPC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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