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Aliases for PABPC1 Gene

Aliases for PABPC1 Gene

  • Poly(A) Binding Protein, Cytoplasmic 1 2 3
  • PABP1 3 4 6
  • PAB1 3 4 6
  • PABPC2 3 4
  • PABP 3 6
  • Poly(A)-Binding Protein, Cytoplasmic 2 2
  • Poly(A) Binding Protein, Cytoplasmic 2 3
  • Polyadenylate-Binding Protein 1 3
  • Poly(A)-Binding Protein 1 4
  • PABPL1 3
  • PABP-1 4

External Ids for PABPC1 Gene

Previous HGNC Symbols for PABPC1 Gene

  • PAB1
  • PABPC2

Previous GeneCards Identifiers for PABPC1 Gene

  • GC08M100720
  • GC08M101785
  • GC08M101383
  • GC08M101671
  • GC08M101784
  • GC08M101715
  • GC08M096913

Summaries for PABPC1 Gene

Entrez Gene Summary for PABPC1 Gene

  • This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.[provided by RefSeq, Aug 2010]

GeneCards Summary for PABPC1 Gene

PABPC1 (Poly(A) Binding Protein, Cytoplasmic 1) is a Protein Coding gene. Diseases associated with PABPC1 include myotonic dystrophy 2 and rift valley fever. Among its related pathways are TGF-Beta Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include nucleotide binding and poly(A) binding. An important paralog of this gene is PABPC5.

UniProtKB/Swiss-Prot for PABPC1 Gene

  • Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.

Gene Wiki entry for PABPC1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PABPC1 Gene

Genomics for PABPC1 Gene

Regulatory Elements for PABPC1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PABPC1 Gene

Start:
100,685,816 bp from pter
End:
100,722,809 bp from pter
Size:
36,994 bases
Orientation:
Minus strand

Genomic View for PABPC1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PABPC1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PABPC1 Gene

Proteins for PABPC1 Gene

  • Protein details for PABPC1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11940-PABP1_HUMAN
    Recommended name:
    Polyadenylate-binding protein 1
    Protein Accession:
    P11940
    Secondary Accessions:
    • Q15097
    • Q93004

    Protein attributes for PABPC1 Gene

    Size:
    636 amino acids
    Molecular mass:
    70671 Da
    Quaternary structure:
    • May interact with SETX (PubMed:21700224). May form homodimers. Component of a multisubunit autoregulatory ribonucleoprotein complex (ARC), at least composed of IGF2BP1, PABPC1 and CSDE1. Directly interacts with IGF2BP1. Part of a complex associated with the FOS mCRD domain and consisting of HNRPD, SYNCRIP, PAIP1 and CSDE1/UNR. Interacts with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1 and PAIP2. Interacts with PAIP1 with a 1:1 stoichiometry and with PAIP2 with a 1:2 stoichiometry. The interaction with CSDE1 is direct and RNA-independent. Found in a mRNP complex with YBX2. Interacts with PAPD4/GLD2. Identified in the spliceosome C complex. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with NFX1. Interacts with PIWIL1. Interacts with AGO1, AGO2, GSPT1 and GSPT2. Interacts with human cytomegalovirus/HHV-5 protein UL69. Interacts with LARP1 and LARP4B. Interacts (via the second and third RRM domains and the C-terminus) with PAIP2B (via central acidic portion and C-terminus).
    Miscellaneous:
    • Many viruses shutoff host mRNA translational machinery by inhibiting cellular PABPC1 activity using different mechanisms. Picornaviruses, caliciviruses or lentiviruses encode proteases that cleave PABPC1 at several defined sites in the proline-rich linker region between RRMs and the C-terminal domain. Rotaviruses, gammherpesviruses and bunyamwera virus relocalize PABPC1 from the cytoplasm to the nucleus thus altering its function. Many of these viruses translate their mRNA in a PABPC1-independent manner and are unaffected by host PABPC1 inhibition

    Three dimensional structures from OCA and Proteopedia for PABPC1 Gene

    Alternative splice isoforms for PABPC1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PABPC1 Gene

Proteomics data for PABPC1 Gene at MOPED

Post-translational modifications for PABPC1 Gene

  • Methylated by CARM1. Arg-493 is dimethylated, probably to asymmetric dimethylarginine.
  • Phosphorylated by MAPKAPK2.
  • Ubiquitination at Lys78, Lys95, Lys104, Lys108, Lys113, Lys129, Lys138, Lys157, Lys188, Lys196, Lys208, Lys213, Lys231, Lys259, Lys284, Lys299, Lys312, Lys333, Lys348, Lys361, Lys512, Lys620, and Lys625
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PABPC1 (PABP 1)

No data available for DME Specific Peptides for PABPC1 Gene

Domains for PABPC1 Gene

Gene Families for PABPC1 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Suggested Antigen Peptide Sequences for PABPC1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11940

UniProtKB/Swiss-Prot:

PABP1_HUMAN :
  • P11940
Domain:
  • The RNA-binding domains RRM1 and RRM2 and the C-terminus (last 138 amino acids) regions interact with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1, respectively
  • The RNA-binding domains RRM2 and RRM3 and the C-terminus (last 138 amino acids) regions interact with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP2, respectively
  • Contains 1 PABC domain.
  • Contains 4 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the polyadenylate-binding protein type-1 family.
genes like me logo Genes that share domains with PABPC1: view

Function for PABPC1 Gene

Molecular function for PABPC1 Gene

GENATLAS Biochemistry: poly (A) binding protein,cytoplasmic 1,ubiquitously expressed,major cytoplasmic RNA-binding protein,70kDA,with a splicing variant (38kDa),involved in the regulation of translation initiation,mRNA stability,regulation of poly(A) tail length,translationally controlled through a cis-regulatory element composed of a cytidine residue at the cap site followed by an interrupted stretch ol pyrimidines (5 - TOP motif)
UniProtKB/Swiss-Prot Function: Binds the poly(A) tail of mRNA, including that of its own transcript. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.

Gene Ontology (GO) - Molecular Function for PABPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding --
GO:0003729 mRNA binding IEA --
GO:0005515 protein binding IPI 11172725
genes like me logo Genes that share ontologies with PABPC1: view

Phenotypes for PABPC1 Gene

GenomeRNAi human phenotypes for PABPC1:
genes like me logo Genes that share phenotypes with PABPC1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PABPC1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PABPC1 Gene

Localization for PABPC1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PABPC1 Gene

Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the cytoplasm and the nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PABPC1 Gene COMPARTMENTS Subcellular localization image for PABPC1 gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PABPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21940797
GO:0005737 cytoplasm TAS 9582337
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0010494 cytoplasmic stress granule IDA 21883093
genes like me logo Genes that share ontologies with PABPC1: view

Pathways for PABPC1 Gene

genes like me logo Genes that share pathways with PABPC1: view

Pathways by source for PABPC1 Gene

2 Qiagen pathways for PABPC1 Gene
1 Cell Signaling Technology pathway for PABPC1 Gene
1 BioSystems pathway for PABPC1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PABPC1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay TAS --
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening TAS --
GO:0000398 mRNA splicing, via spliceosome IC 11991638
GO:0006378 mRNA polyadenylation TAS 2885805
genes like me logo Genes that share ontologies with PABPC1: view

Compounds for PABPC1 Gene

(2) Novoseek inferred chemical compound relationships for PABPC1 Gene

Compound -log(P) Hits PubMed IDs
pabc 88.3 4
adenylate 79.7 95
genes like me logo Genes that share compounds with PABPC1: view

Transcripts for PABPC1 Gene

Unigene Clusters for PABPC1 Gene

Poly(A) binding protein, cytoplasmic 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PABPC1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PABPC1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ·
SP1: -
SP2: - -
SP3: - - -
SP4: - -
SP5: - - - - - -
SP6: -
SP7: -
SP8:
SP9: - -
SP10:
SP11: -
SP12: -

ExUns: 12c ^ 13a · 13b ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for PABPC1 Gene

GeneLoc Exon Structure for
PABPC1
ECgene alternative splicing isoforms for
PABPC1

Expression for PABPC1 Gene

mRNA expression in normal human tissues for PABPC1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PABPC1 Gene

SOURCE GeneReport for Unigene cluster for PABPC1 Gene Hs.387804

mRNA Expression by UniProt/SwissProt for PABPC1 Gene

P11940-PABP1_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with PABPC1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for PABPC1 Gene

Orthologs for PABPC1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PABPC1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PABPC1 35
  • 95.96 (n)
  • 100 (a)
PABPC1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PABPC1 35
  • 97.01 (n)
  • 100 (a)
PABPC1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pabpc1 35
  • 95.18 (n)
  • 99.69 (a)
Pabpc1 16
Pabpc1 36
  • 100 (a)
OneToMany
Pabpc6 36
  • 81 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 100 (a)
ManyToMany
-- 36
  • 89 (a)
ManyToMany
-- 36
  • 69 (a)
ManyToMany
-- 36
  • 90 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Pabpc1 35
  • 94.97 (n)
  • 99.53 (a)
chicken
(Gallus gallus)
Aves PABPC1 35
  • 88.1 (n)
  • 97.96 (a)
PABPC1 36
  • 98 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia pabpc1-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia pabpc1 35
  • 82.38 (n)
  • 96.04 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8813 35
zebrafish
(Danio rerio)
Actinopterygii pabpc1 35
pabpc1b 35
  • 78.85 (n)
  • 92.41 (a)
pabpc1b 36
  • 92 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta pAbp 37
  • 57 (a)
CG4612 37
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea pab-1 35
  • 58.99 (n)
  • 59.83 (a)
pab-2 37
  • 60 (a)
pab-1 37
  • 53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MIP6 38
soybean
(Glycine max)
eudicotyledons Gma.16632 35
thale cress
(Arabidopsis thaliana)
eudicotyledons PAB8 35
  • 54.76 (n)
  • 51.87 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4189 35
rice
(Oryza sativa)
Liliopsida Os08g0314800 35
  • 55.11 (n)
  • 51.01 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.25019 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4802 35
Species with no ortholog for PABPC1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PABPC1 Gene

ENSEMBL:
Gene Tree for PABPC1 (if available)
TreeFam:
Gene Tree for PABPC1 (if available)

Paralogs for PABPC1 Gene

genes like me logo Genes that share paralogs with PABPC1: view

Variants for PABPC1 Gene

Sequence variations from dbSNP and Humsavar for PABPC1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs11146 -- 100,712,657(-) CCAGA(C/T)ACCAG missense, reference
rs1039153 -- 100,710,138(+) GATGC(C/T)TCACT intron-variant
rs1064427 -- 100,709,507(-) AACCC(C/T)TACCA reference, synonymous-codon
rs1693552 -- 100,705,461(+) GTACT(A/G)TCATA intron-variant
rs1693553 -- 100,706,124(+) ACATA(C/G)AGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PABPC1 Gene

Variant ID Type Subtype PubMed ID
esv2737360 CNV Deletion 23290073
esv2737361 CNV Deletion 23290073
esv2050419 CNV Deletion 18987734
esv2737364 CNV Deletion 23290073
esv2737365 CNV Deletion 23290073
nsv824694 CNV Gain 20364138

Relevant External Links for PABPC1 Gene

HapMap Linkage Disequilibrium report
PABPC1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PABPC1 Gene

Disorders for PABPC1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for PABPC1 Gene including...

Search for PABPC1 Gene in MalaCards »

(5) Novoseek inferred disease relationships for PABPC1 Gene

Disease -log(P) Hits PubMed IDs
erythroleukemia 21.2 1
neurodegeneration 7.15 1
tumors 2.24 2
shock 0 7
immunodeficiency 0 2
genes like me logo Genes that share disorders with PABPC1: view

No data available for UniProtKB/Swiss-Prot for PABPC1 Gene

Publications for PABPC1 Gene

  1. The mRNA poly(A)-binding protein: localization, abundance, and RNA- binding specificity. (PMID: 7908267) Goerlach M. … Dreyfuss G. (Exp. Cell Res. 1994) 3 4 23
  2. Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. (PMID: 9548260) Craig A.W.B. … Sonenberg N. (Nature 1998) 3 4 23
  3. The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm. (PMID: 9582337) Afonina E. … Pavlakis G.N. (J. Biol. Chem. 1998) 3 4 23
  4. A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. (PMID: 11051545) Grosset C. … Shyu A.-B. (Cell 2000) 3 4 23
  5. Translational repression by a novel partner of human poly(A) binding protein, Paip2. (PMID: 11172725) Khaleghpour K. … Sonenberg N. (Mol. Cell 2001) 3 4 23

Products for PABPC1 Gene

Sources for PABPC1 Gene

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