V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

PABPC1 Gene

protein-coding GIFtS: 63

GC08M101784

poly(A) binding protein, cytoplasmic 1
(Previous names: poly(A)-binding protein, cytoplasmic 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: PAB1, PABPC2)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
PAB1 ^², ³, ⁵
PABP ^², ⁵
PABP1 ^¹, ², ³, ⁵
PABPC2 ^², ³
PABPL1 ^¹, ²

Descriptions
PABP 1 ^³
Poly(A)-binding protein 1 ^³
poly(A) binding protein, cytoplasmic 1 ^²
poly(A) binding protein, cytoplasmic 2 ^²
poly(A)-binding protein, cytoplasmic 2 ^¹

External Ids
HGNC: 8554¹
Entrez Gene: 26986²
UniProtKB: P11940³
Ensembl: ENSG00000070756⁷

Search outside databases for aliases for PABPC1 gene

Previous GC identifers: GC08M100720 GC08M101785 GC08M101383 GC08M101671

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for PABPC1:

The poly(A)-binding protein (PABP), which is found complexed to the 3-prime poly(A) tail of

eukaryotic mRNA, is required for poly(A) shortening and translation initiation. In humans, the

PABPs comprise a small nuclear isoform and a conserved gene family that displays at least 3

functional proteins: PABP1 (PABPC1), inducible PABP (iPABP, or PABPC4; MIM 603407), and PABP3

(PABPC3; MIM 604680). In addition, there are at least 4 pseudogenes, PABPCP1 to PABPCP4.[supplied

by OMIM]

UniProtKB/Swiss-Prot: PABP1_HUMAN, P11940

Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of

mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can

either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences

other than poly(A) in vivo. May be involved in translationally coupled mRNA turnover. Implicated

with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay

of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain

Gene Wiki entry for PABPC1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the PABPC1 gene

Entrez Gene cytogenetic band: 8q22.2-q23 Ensembl cytogenetic band: 8q22.3 HGNC cytogenetic band: 8q22.2-q23

PABPC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M101784: (about GC identifiers)

Start:	101,784,320 bp from pter
End:	101,803,491 bp from pter
Size:	19,172 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_008046.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: PABP1_HUMAN, P11940 (See protein sequence)

Recommended Name: Polyadenylate-binding protein 1

Size: 636 amino acids; 70671 Da

Subunit: Component of a multi subunit autoregulatory ribonucleoprotein complex (ARC), at least

composed of IGF2BP1, PABPC1 and CSDE1. Interacts with IGF2BP1. Part of a complex associated with

the FOS mCRD domain and consisting of HNRPD, SYNCRIP, PAIP1 and CSDE1/UNR. Interacts with the

PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1 and PAIP2. Interacts with PAIP1 with a

1:1 stoichiometry and with PAIP2 with a 1:2 stoichiometry. The interaction with CSDE1 is direct

and RNA-independent. Found in a mRNP complex with YBX2. Interacts with PAPD4/GLD2. Identified in

the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1,

DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1,

HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH,

MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22,

RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB,

SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11,

THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. Interacts with PIWIL1 (By similarity). Interacts with NFX1

Subcellular location: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus.

Relocalizes to the nucleus upon rotavirus A infection

Caution: Was originally (Ref.4) termed polyadenylate binding protein II

PDB structures from and Proteopedia :

1CVJ (3D)

1G9L (3D)

1JGN (3D)

1JH4 (3D)

Secondary accessions: Q15097 Q93004

Alternative splicing: 2 isoforms: P11940-1 P11940-2

Post-translational modifications:

Methylated by CARM1¹

Arg-493 is dimethylated, probably to asymmetric dimethylarginine¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002559.2

ENSEMBL proteins:

ENSP00000174661 ENSP00000313007

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (PABP)
	Human Recombinant Proteins from Abnova (PABPC1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005681	spliceosome	IEA	--
GO:0005737	cytoplasm	TAS	9582337
GO:0005829	cytosol	EXP	12588972

About this table

Antibodies for PABPC1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of PABPC1
	Sigma-Aldrich Antibody Arrays and Antibodies for PABPC1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for PABPC1 (PABP1)
	Antibodies from Abcam (PABP), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibody for PABPC1

Assays for PABPC1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P11940

ProtoNet protein and cluster: P11940

2 Blocks protein families:

IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

IPB002004 Polyadenylate-binding protein/HECT-associated

UniProtKB/Swiss-Prot: PABP1_HUMAN, P11940

Domain: The RNA-binding domains RRM1 and RRM2 and the C-terminus (last 138 amino acids) regions

interact with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP1, respectively

Domain: The RNA-binding domains RRM2 and RRM3 and the C-terminus (last 138 amino acids) regions

interact with the PABPC1-interacting motif-1 (PAM1) and -2 (PAM2) of PAIP2, respectively

Similarity: Belongs to the polyadenylate-binding protein type-1 family

Similarity: Contains 1 PABC domain

Similarity: Contains 4 RRM (RNA recognition motif) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PABPC1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PABPC1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002568

Applied Biosystems Silencer® siRNAs for PABPC1

Sigma-Aldrich siRNA for PABPC1

Sigma-Aldrich shRNA for PABPC1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for PABPC1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002568
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002568
untagged cDNA clone in CMV expression vector: NM_002568

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002568

UniProtKB/Swiss-Prot: PABP1_HUMAN, P11940

Function: Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of

mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can

either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences

other than poly(A) in vivo. May be involved in translationally coupled mRNA turnover. Implicated

with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay

of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain

Genatlas biochemistry entry for PABPC1:

poly (A) binding protein,cytoplasmic 1,ubiquitously expressed,major cytoplasmic RNA-binding

protein,70kDA,with a splicing variant (38kDa),involved in the regulation of translation

initiation,mRNA stability,regulation of poly(A) tail length,translationally controlled through a

cis-regulatory element composed of a cytidine residue at the cap site followed by an interrupted

stretch ol pyrimidines (5' - TOP motif)

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003723	RNA binding	IEA	--
GO:0008022	protein C-terminus binding	IPI	15663938
GO:0008143	poly(A) binding	TAS	2885805
GO:0008494	translation activator activity	TAS	11997512

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for PABPC1

5/383 Interacting proteins for PABPC1 (ENSP00000313007³ P11940^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 383 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ATXN2	Q99700¹	STRING (score=.98) EBI-81531, EBI-697691
EIF4A2	Q14240¹	STRING (score=.951) EBI-81531, EBI-73473
RPL13AP18	P40429²	STRING (score=.946) MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791
RPS15AP24	P62244²	STRING (score=.899) MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791
RPS26P20	P62854²	STRING (score=.899) MINT-6489539 MINT-6488590 MINT-6489355 MINT-6488791

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006378	mRNA polyadenylation	TAS	2885805
GO:0006397	mRNA processing	IEA	--
GO:0008380	RNA splicing	IEA	--
GO:0048255	mRNA stabilization	TAS	11997512

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for PABPC1
1 Novoseek chemical compound relationship for PABPC1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pabc	78.95	1	14685257 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (PABPC1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (PABPC1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002568

Sigma-Aldrich siRNA for PABPC1

Sigma-Aldrich shRNA for PABPC1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002568

REFSEQ mRNAs for PABPC1 gene:

NM_002568.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002568

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002568
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002568
                                 untagged cDNA clone in CMV expression vector: NM_002568

Additional cDNA sequence:

AK057080.1 AK130523.1 AK298990.1 AK303120.1 BC015958.2 BC023217.1 BC023520.2 Y00345.1

Z48501.1

24/107 DOTS entries (see all 107 ):

DT.95267608 DT.100700601 DT.92470838 DT.92470896 DT.100700595 DT.92470903 DT.91954612 DT.121466365

DT.100700590 DT.95267607 DT.91870787 DT.121466401 DT.100043224 DT.100700594 DT.121466463 DT.95267689

DT.91733252 DT.92359426 DT.97869208 DT.91661782 DT.100852698 DT.100700596 DT.91800129 DT.91801712

24/2559 AceView cDNA sequences (see all 2559 ):

BQ007757 AA988483 AI634445 CB851044 BU735637 CA420871 C03993 BM511956

BM843167 BE620321 BU845230 AI718601 BM708494 AA373063 BQ128124 AI076250

BM722633 BF035784 CB146292 AA860067 BM479486 BU169615 BU736366 BM990588

highest scoring ESTs for PABPC1:

Y00345 Z48501 AA156390 AA223634 AA311953 AA318103 AA319539 AA361702 AA361898 AA486626

Unigene Cluster for PABPC1:

Poly(A) binding protein, cytoplasmic 1

Hs.387804 [show with all ESTs]

Unigene Representative Sequence: NM_002568

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for PABPC1 (see all 12 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3a	·	3b	·	3c	·	3d	^	4a	·	4b	·	4c	^	5a	·	5b	·	5c	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9	^	10	^	11	^	12a	·	12b	·
SP1:																									-
SP2:																									-								-
SP3:																					-		-		-
SP4:																									-								-
SP5:							-		-		-		-		-										-

ExUns:	12c	^	13a	·	13b	^	14
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PABPC1

2 Ensembl transcripts including schematic representations:

ENST00000347137 ENST00000318607

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

PABPC1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for PABPC1

¹ / ² / ³

10 probe-sets matching PABPC1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31950_at²^{, 3}	U95-A	3	1.00	0.62	0.93	0.95	Y00345	1.00	1.00	1.00	1
31951_s_at²^{, 3}	U95-A	7	1.00	0.30	0.98	0.91	Z48501	1.00	0.87	0.94	1
59809_f_at²^{, 3}	U95-C	2	0.81	0.92	0.99	1.14	AW020548	0.40	1.00	0.76	1
208113_x_at²	U133-A	6	0.91	0.34	--	--	--	--	--	--	--
215157_x_at²^{, 3}	U133-A	7	0.91	0.24	--	--	AI734929	0.40	1.00	0.76	1
215823_x_at²	U133-A	6	0.73	0.26	--	--	--	--	--	--	--
208113_x_at²	U133Plus2	6	0.91	0.34	--	--	--	--	--	--	--
215157_x_at²	U133Plus2	7	0.91	0.24	--	--	--	--	--	--	--
215823_x_at²	U133Plus2	6	0.73	0.26	--	--	--	--	--	--	--
1560770_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AAAAGAAACT

SOURCE GeneReport for Unigene cluster: Hs.387804
UniProtKB/Swiss-Prot: PABP1_HUMAN, P11940
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PABPC1 gene from 5/25 species (see all 25 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PABPC1¹	--	poly(A) binding protein, cytoplasmic 1	96.28(n) 99.21(a)	612751 XM_851497.1 XP_856590.1
rat (Rattus norvegicus)	Pabpc1¹	--	poly(A) binding protein, cytoplasmic 1	94.97(n) 99.53(a)	171350 NM_134353.2 NP_599180.1
mouse (Mus musculus)	Pabpc1^{1, 5}	15⁵	poly(A) binding protein, cytoplasmic 1⁵ poly A binding protein, cytoplasmic 1¹	95.18(n)¹ 99.69(a)¹	18458¹ NM_008774.2¹ NP_032800.2¹ AJ279847⁵ AK005009⁵ (see all 29)
chicken (Gallus gallus)	RCJMB04_7l20¹	--	poly(A) binding protein, cytoplasmic 1	88.1(n) 97.96(a)	430997 NM_001031597.1 NP_001026768.1
zebrafish (Danio rerio)	pabpc1²	--	poly A binding protein, cytoplasmic 1	78.97(n)	324517 BC059662.1

About this table Species with no ortholog for PABPC1

ENSEMBL Gene Tree for PABPC1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PABPC1 gene

PABPC1L² PABPC3² PABPC5² PABPC1L2B² PABPCP2² PABPC4² PABPC1L2A²

Pseudogenes

3 related pseudogenes

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/155 NCBI SNPs in PABPC1 are shown (see all 155 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 72)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs1693548^1,2	A,C,F	101783975(+)	`GAATTC/TGAGAC`	1	--	ng5¹		1	MN	184
--	rs7837110^1,2	A,C,F	101783956(+)	`TGCTTA/GTGCTT`	1	--	ng5¹		3	NA	142
	rs10092603^1,2	H	101784016(+)	`ctaccC/Tgcaaa`	1	--	ng5¹		3	EU EA	300
	rs11146^1,2	H	101794061(-)	`CCAGAT/CACCAG`	1	H/Y	mis¹		4	EU EA WA	406
--	rs3202310^1,2	H	101784408(-)	`CAGTTC/TTGTTT`	1	--	ut3¹		1	WA	102
--	rs16898715^1,2	F	101804386(-)	`GTCCAG/ATGAAG`	1	--	ng3¹		2	MN EA	356
	rs1064427^1,2	H	101790911(-)	`AACCCC/TTACCA`	1	P/P	syn¹ ese³		4	EU EA WA	416
	rs3133575^1,2	A,C,F,H,O	101794427(+)	`ACATAC/GACTTC`	1	--	int¹		12	EA NA EU WA	1052
	rs7829465^1,2	A,C,F,H	101794270(+)	`AAGACA/GAATTT`	1	--	int¹		4	EU EA WA	412
	rs2132853^1,2	A,C,F,H	101801524(+)	`TCATAT/GTTCGA`	1	--	int¹		8	EU EA WA	832

About this table

HapMap Linkage Disequilibrium images for PABPC1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 604679

5 Novoseek disease relationships for PABPC1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
erythroleukemia	23.54	1	10373504 (1)
neurodegeneration	11.40	1	18271626 (1)
tumors	1.20	1	15353001 (1)
shock	0.00	7	19087191 (4), 10477262 (1)
immunodeficiency	0.00	1	16594896 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/155 PubMed articles for PABPC1 gene (see all 155 ):

Human mRNA polyadenylate binding protein: evolutionary conservation of a nucleic acid binding motif. (PubMed id 2885805)^{2, 3, 4} Grange T.... Pictet R. (1987)
The human poly(A)-binding protein 1 shuttles between the nucleus and the cytoplasm. (PubMed id 9582337)^{1, 3, 4} Afonina E.... Pavlakis G.N. (1998)
Dual interactions of the translational repressor Paip2 with poly(A) binding protein. (PubMed id 11438674)^{1, 3, 4} Khaleghpour K.... Sonenberg N. (2001)
Paip1 interacts with poly(A) binding protein through two independent binding motifs. (PubMed id 11997512)^{1, 3, 4} Roy G.... Sonenberg N. (2002)
Translational repression by a novel partner of human poly(A) binding protein, Paip2. (PubMed id 11172725)^{1, 3, 4} Khaleghpour K.... Sonenberg N. (2001)
PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. (PubMed id 11850402)^{1, 3, 4} Lee J. and Bedford M.T. (2002)
The mRNA poly(A)-binding protein: localization, abundance, and RNA- binding specificity. (PubMed id 7908267)^{1, 3, 4} Goerlach M.... Dreyfuss G. (1994)
Recognition of polyadenylate RNA by the poly(A)-binding protein. (PubMed id 10499800)^{1, 3, 4} Deo R.C.... Burley S.K. (1999)
UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. (PubMed id 15314026)^{1, 3, 4} Chang T.-C.... Shyu A.-B. (2004)
Interaction of polyadenylate-binding protein with the eIF4G homologue PAIP enhances translation. (PubMed id 9548260)^{1, 3, 4} Craig A.W.B.... Sonenberg N. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 26986	HGNC: 8554	AceView: PABPC1	Ensembl:ENSG00000070756	euGenes: HUgn26986
ECgene: PABPC1	H-InvDB: PABPC1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for PABPC1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for PABPC1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for PABPC1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PABPC1		Antibodies for PABPC1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PABPC1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (PABPC1)
	Search for Antibodies
	Chimera RNAi (PABPC1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for PABPC1 (PABP1)

	Recombinant Proteins (PABP)
	Antibodies (PABP)

Search OriGene for PABPC1

Search Tocris compounds for PABPC1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for PABPC1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
PABPC1 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

PABPC1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for PABPC1

Summaries
for PABPC1

Genomic Location
for PABPC1

Proteins
for PABPC1

Protein Domains/
Families
for PABPC1

Gene Function
for PABPC1

Pathways & Interactions
for PABPC1

Drugs & Compounds
for PABPC1

Transcripts
for PABPC1

Expression
for PABPC1

Orthologs
for PABPC1

Paralogs
for PABPC1

SNPs/Variants
for PABPC1

Disorders & Mutations
for PABPC1

Medical News
for PABPC1

Publications
for PABPC1

Search for PABPC1

Genome Databases showing PABPC1

Other Databases showing PABPC1

Specialized Databases showing PABPC1

Licensable Technologies
for PABPC1

Services
for PABPC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

PABPC1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor PABPC1

Summariesfor PABPC1

Genomic Locationfor PABPC1

Proteinsfor PABPC1

Protein Domains/Familiesfor PABPC1

Gene Functionfor PABPC1

Pathways & Interactionsfor PABPC1

Drugs & Compoundsfor PABPC1

Transcriptsfor PABPC1

Expression for PABPC1

Orthologsfor PABPC1

Paralogsfor PABPC1

SNPs/Variantsfor PABPC1

Disorders & Mutationsfor PABPC1

Medical Newsfor PABPC1

Publicationsfor PABPC1

Search for PABPC1

Genome Databases showing PABPC1

Other Databases showing PABPC1

Specialized Databases showing PABPC1

Licensable Technologiesfor PABPC1

Servicesfor PABPC1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for PABPC1

Summaries
for PABPC1

Genomic Location
for PABPC1

Proteins
for PABPC1

Protein Domains/
Families
for PABPC1

Gene Function
for PABPC1

Pathways & Interactions
for PABPC1

Drugs & Compounds
for PABPC1

Transcripts
for PABPC1

Expression
for PABPC1

Orthologs
for PABPC1

Paralogs
for PABPC1

SNPs/Variants
for PABPC1

Disorders & Mutations
for PABPC1

Medical News
for PABPC1

Publications
for PABPC1

Licensable Technologies
for PABPC1

Services
for PABPC1