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Aliases for PAAF1 Gene

Aliases for PAAF1 Gene

  • Proteasomal ATPase Associated Factor 1 2 3 5
  • WD Repeat-Containing Protein 71 3 4
  • WD Repeat Domain 71 2 3
  • WDR71 3 4
  • Protein G-16 4
  • Rpn14 3
  • PAAF 3

External Ids for PAAF1 Gene

Previous HGNC Symbols for PAAF1 Gene

  • WDR71

Previous GeneCards Identifiers for PAAF1 Gene

  • GC11P073267
  • GC11P073588
  • GC11P069884

Summaries for PAAF1 Gene

Entrez Gene Summary for PAAF1 Gene

  • This gene encodes a WD repeat-containing protein involved in regulation of association of proteasome components. During HIV infection, the encoded protein is thought to promote provirus transcription through recruitment of the 19S regulatory complex. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2012]

GeneCards Summary for PAAF1 Gene

PAAF1 (Proteasomal ATPase Associated Factor 1) is a Protein Coding gene. Diseases associated with PAAF1 include bladder leiomyoma and bladder benign neoplasm.

UniProtKB/Swiss-Prot for PAAF1 Gene

  • Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation.

Gene Wiki entry for PAAF1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PAAF1 Gene

Genomics for PAAF1 Gene

Regulatory Elements for PAAF1 Gene

Promoters for PAAF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PAAF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PAAF1 Gene

Chromosome:
11
Start:
73,876,699 bp from pter
End:
73,931,124 bp from pter
Size:
54,426 bases
Orientation:
Plus strand

Genomic View for PAAF1 Gene

Genes around PAAF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PAAF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PAAF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PAAF1 Gene

Proteins for PAAF1 Gene

  • Protein details for PAAF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRP4-PAAF1_HUMAN
    Recommended name:
    Proteasomal ATPase-associated factor 1
    Protein Accession:
    Q9BRP4
    Secondary Accessions:
    • A6NDR5
    • B4DPB0
    • B7ZAS9
    • Q4G165
    • Q53HS9
    • Q7Z500
    • Q8TBU6
    • Q9HAB6

    Protein attributes for PAAF1 Gene

    Size:
    392 amino acids
    Molecular mass:
    42190 Da
    Quaternary structure:
    • Interacts with PSMC1, PSMC2, PSMC3, PSMC4, PSMC5 and PSMC6. Interacts with HIV-1 Tat. Interacts with SUPT6H.

    Alternative splice isoforms for PAAF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PAAF1 Gene

Proteomics data for PAAF1 Gene at MOPED

Post-translational modifications for PAAF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for PAAF1 Gene

Domains & Families for PAAF1 Gene

Gene Families for PAAF1 Gene

Suggested Antigen Peptide Sequences for PAAF1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BRP4

UniProtKB/Swiss-Prot:

PAAF1_HUMAN :
  • Belongs to the WD repeat PAAF1/RPN14 family.
  • Contains 7 WD repeats.
Family:
  • Belongs to the WD repeat PAAF1/RPN14 family.
Similarity:
  • Contains 7 WD repeats.
genes like me logo Genes that share domains with PAAF1: view

Function for PAAF1 Gene

Molecular function for PAAF1 Gene

UniProtKB/Swiss-Prot Function:
Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation.

Phenotypes for PAAF1 Gene

GenomeRNAi human phenotypes for PAAF1:
genes like me logo Genes that share phenotypes with PAAF1: view

Animal Model Products

CRISPR Products

miRNA for PAAF1 Gene

miRTarBase miRNAs that target PAAF1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PAAF1 Gene

Localization for PAAF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PAAF1 Gene COMPARTMENTS Subcellular localization image for PAAF1 gene
Compartment Confidence
cytosol 2
nucleus 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PAAF1 Gene

Pathways & Interactions for PAAF1 Gene

SuperPathways for PAAF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PAAF1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PAAF1 Gene

Drugs & Compounds for PAAF1 Gene

No Compound Related Data Available

Transcripts for PAAF1 Gene

Unigene Clusters for PAAF1 Gene

Proteasomal ATPase-associated factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PAAF1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: - - - -
SP5:
SP6: -

Relevant External Links for PAAF1 Gene

GeneLoc Exon Structure for
PAAF1
ECgene alternative splicing isoforms for
PAAF1

Expression for PAAF1 Gene

mRNA expression in normal human tissues for PAAF1 Gene

Protein differential expression in normal tissues from HIPED for PAAF1 Gene

This gene is overexpressed in Ovary (11.3) and Peripheral blood mononuclear cells (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PAAF1 Gene



SOURCE GeneReport for Unigene cluster for PAAF1 Gene Hs.525017

mRNA Expression by UniProt/SwissProt for PAAF1 Gene

Q9BRP4-PAAF1_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in kidney, brain and testis.
genes like me logo Genes that share expression patterns with PAAF1: view

Protein tissue co-expression partners for PAAF1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PAAF1 Gene

Orthologs for PAAF1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PAAF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PAAF1 35
  • 93.96 (n)
  • 95.41 (a)
-- 36
  • 83 (a)
OneToMany
PAAF1 36
  • 95 (a)
OneToMany
dog
(Canis familiaris)
Mammalia PAAF1 35
  • 93.28 (n)
  • 95.41 (a)
PAAF1 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PAAF1 35
  • 99.49 (n)
  • 98.72 (a)
PAAF1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PAAF1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PAAF1 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves PAAF1 35
  • 76.45 (n)
  • 82.14 (a)
PAAF1 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PAAF1 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia thul16 35
  • 64.62 (n)
  • 67.01 (a)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y39G10AR.9 35
  • 42.15 (n)
  • 28.37 (a)
Y39G10AR.9 36
  • 23 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RPN14 36
  • 24 (a)
OneToOne
RPN14 38
Species with no ortholog for PAAF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for PAAF1 Gene

ENSEMBL:
Gene Tree for PAAF1 (if available)
TreeFam:
Gene Tree for PAAF1 (if available)

Paralogs for PAAF1 Gene

Pseudogenes.org Pseudogenes for PAAF1 Gene

genes like me logo Genes that share paralogs with PAAF1: view

No data available for Paralogs for PAAF1 Gene

Variants for PAAF1 Gene

Sequence variations from dbSNP and Humsavar for PAAF1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs17850051 - 73,887,423(+) TACAG(C/T)TTCAG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs3741138 - 73,909,492(-) AGCAG(C/G)CTGAG nc-transcript-variant, reference, missense
rs2067912 - 73,900,304(+) GAATT(C/G)TTGCA intron-variant, nc-transcript-variant, reference, missense
rs635962 -- 73,917,824(+) cgaga(A/C)catgc intron-variant
rs1132819 -- 73,880,566(+) CCTGT(A/G)GTCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PAAF1 Gene

Variant ID Type Subtype PubMed ID
nsv510946 CNV Complex 20534489

Variation tolerance for PAAF1 Gene

Residual Variation Intolerance Score: 46.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.12; 84.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PAAF1 Gene

HapMap Linkage Disequilibrium report
PAAF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PAAF1 Gene

Disorders for PAAF1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PAAF1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
bladder leiomyoma
  • leiomyoma of the urinary bladder
bladder benign neoplasm
hiv-1
  • aids, slow progression to
- elite association - COSMIC cancer census association via MalaCards
Search PAAF1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PAAF1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PAAF1
genes like me logo Genes that share disorders with PAAF1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PAAF1 Gene

Publications for PAAF1 Gene

  1. Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PMID: 15831487) Park Y. … Yoon J.-B. (Mol. Cell. Biol. 2005) 2 3 4 23 67
  2. The proteasome regulates HIV-1 transcription by both proteolytic and nonproteolytic mechanisms. (PMID: 17289585) Lassot I. … Kiernan R.E. (Mol. Cell 2007) 2 3
  3. Lower expression of catalytic and structural subunits of the proteasome contributes to decreased proteolysis in peripheral blood T lymphocytes during aging. (PMID: 17317272) Ponnappan S. … Ponnappan U. (Int. J. Biochem. Cell Biol. 2007) 2 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for PAAF1 Gene

Sources for PAAF1 Gene

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