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PA2G4 Gene

protein-coding   GIFtS: 63
GCID: GC12P056498

Proliferation-Associated 2G4, 38kDa

(Previous names: proliferation-associated 2G4, 38kD)
Microbiology & Infectious Diseases Congress
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at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Proliferation-Associated 2G4, 38kDa1 2     ErbB-3 Binding Protein 12
Cell Cycle Protein P38-2G4 Homolog2 3     ErbB3-Binding Protein Ebp12
ErbB3-Binding Protein 12 3     p38-2G42
EBP12 3     Proliferation-Associated Protein 2G42
Proliferation-Associated 2G4, 38kD1     hG4-13
HG4-12     

External Ids:    HGNC: 85501   Entrez Gene: 50362   Ensembl: ENSG000001705157   OMIM: 6021455   UniProtKB: Q9UQ803   

Export aliases for PA2G4 gene to outside databases

Previous GC identifers: GC12M056378 GC12M056832 GC12P056215 GC12P054784 GC12P053543


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for PA2G4 Gene:
This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in
pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of
intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the
ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a
transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through
its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the
induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and
X, have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for PA2G4 Gene:
PA2G4 (proliferation-associated 2G4, 38kDa) is a protein-coding gene. Diseases associated with PA2G4 include adenoid cystic carcinoma, and adenoiditis. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and ubiquitin protein ligase binding. An important paralog of this gene is ENSG00000257411.

UniProtKB/Swiss-Prot: PA2G4_HUMAN, Q9UQ80
Function: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth
regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand
neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting
histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA
precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of
rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral
IRESs (internal ribosomal entry site) (By similarity)

Gene Wiki entry for PA2G4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the PA2G4 gene promoter:
         AP-1   Tal-1beta   Egr-4   Egr-2   CREB   HOXA5   deltaCREB   SEF-1 (1)   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): PA2G4 promoter sequence
   Search Chromatin IP Primers for PA2G4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat PA2G4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.2

PA2G4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PA2G4 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056498:  view genomic region     (about GC identifiers)

Start:
56,498,103 bp from pter      End:
56,507,694 bp from pter
Size:
9,592 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PA2G4_HUMAN, Q9UQ80 (See protein sequence)
Recommended Name: Proliferation-associated protein 2G4  
Size: 394 amino acids; 43787 Da
Subunit: Interacts with the cytoplasmic domain of non-phosphorylated ERBB3; the interaction requires PKC activity.
Interacts with AR. Treatment with HRG leads to dissociation from ERBB3 and increases association with AR.
Interacts with NCL/nucleolin. Component of a ribonucleoprotein complex containing at least PA2G4, NCL, TOP1,
PABPC2, RPLP0, acetylated histone H1 (HIST1H1A or H1F1), histone H1 2/4, RPL4, RPL8, RPL15, RPL18, RPL18A, RPL21,
RPL11, RPL12, RPL28, RPL27, RPLP2 and RPL24. Interacts with HDAC2. Interacts with RB1; the interaction is
enhanced upon PA2G4 dephosphorylation
Caution: Although it belongs to the peptidase M24 family, it does not contain metal cofactors and lacks
aminopeptidase activity
Sequence caution: Sequence=AAD00646.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for PA2G4:
2Q8K (3D)        3J2I (3D)    
Secondary accessions: O43846 Q9UM59

Explore the universe of human proteins at neXtProt for PA2G4: NX_Q9UQ80

Explore proteomics data for PA2G4 at MOPED

Post-translational modifications: 

  • Phosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal
    phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent1
  • Ubiquitination2 at Lys20, Lys158, Lys172, Lys253, Lys344, Lys376
  • Modification sites at PhosphoSitePlus

  • See PA2G4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006182.2  
    ENSEMBL proteins: 
     ENSP00000302886   ENSP00000448557   ENSP00000447615   ENSP00000447389  

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    PA2G4 Assay Products:

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    Cloud-Clone Corp. CLIAs for PA2G4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR004545 Pap_1
     IPR000994 Pept_M24_structural-domain
     IPR018349 Pept_M24A_MAP2_BS
     IPR011991 WHTH_DNA-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q9UQ80

    ProtoNet protein and cluster: Q9UQ80

    UniProtKB/Swiss-Prot: PA2G4_HUMAN, Q9UQ80
    Similarity: Belongs to the peptidase M24 family


    PA2G4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PA2G4_HUMAN, Q9UQ80
    Function: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth
    regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand
    neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting
    histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA
    precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of
    rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral
    IRESs (internal ribosomal entry site) (By similarity)

         Genatlas biochemistry entry for PA2G4:
    murine cell-cycle P38-2G4 homolog,confined to the nucleus during interphase and cytoplasmic from metaphase through
    to telophase,widely expressed

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA15073182
    GO:0003700sequence-specific DNA binding transcription factor activity IDA15073182
    GO:0003723RNA binding ----
    GO:0005515protein binding IPI11268000
    GO:0016787hydrolase activity ----
         
    PA2G4 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Pa2g4):
     cellular  growth/size/body  limbs/digits/tail  reproductive system 

    PA2G4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for PA2G4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for PA2G4
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    miRNA
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    miRTarBase miRNAs that target PA2G4:
    hsa-mir-24-3p (MIRT030585), hsa-mir-146a-5p (MIRT004018), hsa-mir-423-5p (MIRT038112), hsa-let-7b-5p (MIRT052072), hsa-mir-92b-3p (MIRT040635), hsa-mir-615-3p (MIRT039663), hsa-mir-324-5p (MIRT043048), hsa-mir-92a-3p (MIRT049779), hsa-mir-16-5p (MIRT031824), hsa-mir-744-5p (MIRT037677), hsa-mir-484 (MIRT041942), hsa-let-7e-5p (MIRT051631), hsa-mir-342-3p (MIRT043721)

    Block miRNA regulation of human, mouse, rat PA2G4 using miScript Target Protectors
    7 qRT-PCR Assays for microRNAs that regulate PA2G4:
    hsa-miR-548d-3p hsa-miR-3184 hsa-miR-29a* hsa-miR-1827 hsa-miR-3175 hsa-miR-583 hsa-miR-423-5p
    SwitchGear 3'UTR luciferase reporter plasmidPA2G4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat PA2G4

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    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PA2G4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    PA2G4_HUMAN, Q9UQ80: Cytoplasm. Nucleus, nucleolus. Note=Tranlocates to the nucleus upon treatment with HRG
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA15073182
    GO:0005730nucleolus IDA19037095
    GO:0005737cytoplasm IDA19037095
    GO:0030529ribonucleoprotein complex IEA--
    GO:0070062extracellular vesicular exosome IDA--

    PA2G4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for PA2G4 About    
    See pathways by source

    SuperPathContained pathways About
    1Coregulation of Androgen receptor activity
    Coregulation of Androgen receptor activity


    1 BioSystems Pathway for PA2G4
        Coregulation of Androgen receptor activity



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for PA2G4
    Interactions:

        GeneGlobe Interaction Network for PA2G4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for PA2G4 (Q9UQ801, 2, 3 ENSP000003028864) via UniProtKB, MINT, STRING, and/or I2D (see all 265)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCLP193381, 3, ENSP000003181954EBI-924893,EBI-346967 I2D: score=2 STRING: ENSP00000318195
    RB1P064001, 3, ENSP000002671634EBI-924893,EBI-491274 I2D: score=4 STRING: ENSP00000267163
    SIN3AQ96ST31, 3, ENSP000003536224EBI-924893,EBI-347218 I2D: score=3 STRING: ENSP00000353622
    ERBB3P218603, ENSP000002671014I2D: score=4 STRING: ENSP00000267101
    HDAC2Q927693, ENSP000003813314I2D: score=4 STRING: ENSP00000381331
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006364rRNA processing IEA--
    GO:0006417regulation of translation IEA--
    GO:0007050cell cycle arrest TAS7556453
    GO:0008283cell proliferation TAS7556453

    PA2G4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for PA2G4

    1 Novoseek inferred chemical compound relationship for PA2G4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 32.1 9 15583694 (3), 12165860 (2), 18852121 (2), 19025630 (1)



    PA2G4 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for PA2G4 gene: 
    NM_006191.2  

    Unigene Cluster for PA2G4:

    Proliferation-associated 2G4, 38kDa
    Hs.524498  [show with all ESTs]
    Unigene Representative Sequence: NM_006191
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303305(uc001sjm.3) ENST00000552766 ENST00000553057 ENST00000551061
    ENST00000550166 ENST00000552528 ENST00000552266
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    7 qRT-PCR Assays for microRNAs that regulate PA2G4:
    hsa-miR-548d-3p hsa-miR-3184 hsa-miR-29a* hsa-miR-1827 hsa-miR-3175 hsa-miR-583 hsa-miR-423-5p
    SwitchGear 3'UTR luciferase reporter plasmidPA2G4 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat PA2G4
      QuantiFast Probe-based Assays in human, mouse, rat PA2G4

    Additional mRNA sequence: 

    AK291796.1 BC001951.1 BC007561.1 BC019222.1 BC032111.2 BC069786.1 BC072007.1 U59435.1 
    U87954.1 

    Selected DOTS entries (see all 44):

    DT.91774612  DT.100034293  DT.86995864  DT.100865789  DT.92363174  DT.97867576  DT.100687060  DT.100687071 
    DT.100687069  DT.91670398  DT.97864060  DT.91774599  DT.91774615  DT.100687065  DT.419579  DT.91763237 
    DT.95340993  DT.100845158  DT.100687059  DT.100759294  DT.100877072  DT.121158859  DT.455557  DT.75171491 

    Selected AceView cDNA sequences (see all 780):

    BM928210 CD742771 BQ017921 BG388407 BQ681020 AA928500 BX462472 CA413579 
    BM792772 CR624134 AU143085 BQ690303 BI063730 BQ774649 CR599146 BU630396 
    BX416050 BQ877604 BM772009 AU142335 AA308544 BU176658 BP379334 BM842687 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for PA2G4    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13
    SP1:                    -                                                                                       
    SP2:              -     -                                                                                       
    SP3:                                                                                                            
    SP4:                                                                                                            


    ECgene alternative splicing isoforms for PA2G4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    PA2G4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGATAACCA
    PA2G4 Expression
    About this image


    PA2G4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    PA2G4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    PA2G4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524498

    UniProtKB/Swiss-Prot: PA2G4_HUMAN, Q9UQ80
    Tissue specificity: Expressed in several cell lines tested, including primary and transformed cell lines

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for PA2G4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for PA2G4 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Pa2g41 , 5 proliferation-associated 2G41, 5 92.13(n)1
    98.98(a)1
      10 (77.09 cM)5
    188131  NM_011119.31  NP_035249.11 
     1285577665 
    chicken
    (Gallus gallus)
    Aves PA2G41 proliferation-associated 2G4, 38kDa 81.32(n)
    92.31(a)
      425279  XM_423059.4  XP_423059.4 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    89(a)
    1 → many
    GL343198.1(3724970-3740819)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.89072 Xenopus laevis, Similar to proliferation-associated more 82.1(n)    BC044287.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb37h042 Danio rerio proliferation-associated protein 1, mRNA more 79.25(n)    BC056591.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG105761 , 3 methionyl aminopeptidase3
    CG105761
    56(a)3
    58.26(n)1
    56.3(a)1
      64E63
    386451  NM_139727.31  NP_647984.11 
    worm
    (Caenorhabditis elegans)
    Secernentea W08E12.71 , 3 peptidase3
    W08E12.71
    50(a)3
    54.22(n)1
    49.58(a)1
      IV(3295147-3296523)3
    1770971  NM_067910.61  NP_500311.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARX1(YDR101C)4 Shuttling pre-60S factor; involved in the biogenesis more   --   4(657467-655686) 851678  NP_010386.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ATG21 ATG2 58.14(n)
    52.59(a)
      824343  NM_001203131.1  NP_001190060.1 
    rice
    (Oryza sativa)
    Liliopsida Os05g03505001 Os05g0350500 57.9(n)
    52.29(a)
      4338500  NM_001061809.1  NP_001055274.1 


    ENSEMBL Gene Tree for PA2G4 (if available)
    TreeFam Gene Tree for PA2G4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for PA2G4 gene
    ENSG000002574112  METAP22  
    1 SIMAP similar gene for PA2G4 using alignment to 6 protein entries:     PA2G4_HUMAN (see all proteins):
    METAP2

    PA2G4 for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for PA2G4 (see all 6)
    PGOHUM00000261251 PGOHUM00000247594 PGOHUM00000237834 PGOHUM00000243332 PGOHUM00000236689


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for PA2G4 (see all 215)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37590941,2
    C,F,A,H--56497903(+) TTCGCC/TAGCCG 1 -- us2k112Minor allele frequency- T:0.32EA NA WA 1424
    rs37590951,2
    C,F,H--56497938(+) ACCCAG/CCCTCC 1 -- us2k14Minor allele frequency- C:0.00NS EA 404
    rs348926451,2
    C--56497942(+) AGCCTA/CCCCGA 1 -- us2k10--------
    rs1122378541,2
    C,F--56498018(+) AAACCC/TATTTC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs800119491,2
    C--56498022(+) CTATTC/TCCCCG 1 -- us2k10--------
    rs756021841,2
    C--56498039(+) CTCCGC/TCCCTC 1 -- us2k10--------
    rs7731211,2
    C,F,H--56498241(-) CGCTCC/TTAAGC 1 -- ut5120Minor allele frequency- T:0.11MN NS EA NA WA CSA 2239
    rs1161603991,2
    C,F--56498289(+) GAGAGC/AGGCTA 1 -- ut511Minor allele frequency- A:0.03WA 118
    rs776623191,2
    C,F--56498307(+) GCGGCC/GGAGAG 1 -- ut513Minor allele frequency- G:0.22CSA WA 121
    rs746715561,2
    --56498312(+) CGAGAA/GGACTA 1 -- ut510--------

    HapMap Linkage Disequilibrium report for PA2G4 (56498103 - 56507694 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for PA2G4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832427CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing PA2G4
    DNA2.0 Custom Variant and Variant Library Synthesis for PA2G4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602145    OMIM disorders: --

    18 diseases for PA2G4:    
    About MalaCards
    adenoid cystic carcinoma    adenoiditis    retinoblastoma    oral squamous cell carcinoma
    vitiligo    influenza    prostate cancer    tonsillitis
    prostatitis    squamous cell carcinoma    breast cancer    neuroblastoma
    hiv-1    malaria    thyroiditis    cerebritis
    neuronitis    endotheliitis


    PA2G4 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for PA2G4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 41.3 19 18852121 (4), 15583694 (2), 12682367 (1), 19937055 (1) (see all 6)
    retinoblastoma 34.7 2 12682367 (1)
    breast cancer 24.9 24 18283314 (5), 11268000 (3), 18355957 (3), 10797306 (2) (see all 5)
    tumors 0 4 12682367 (1), 17266032 (1), 19937055 (1)


    Export disorders for PA2G4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for PA2G4 gene, integrated from 10 sources (see all 95):
    (articles sorted by number of sources associating them with PA2G4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and mapping of a human cDNA (PA2G4) that encodes a protein highly homologous to the mouse cell cycle protein p38-2G4. (PubMed id 9345902)1, 2, 3, 9 Lamartine J.... Sylla B.S. (Cytogenet. Cell Genet. 1997)
    2. Ebp1, an ErbB-3 binding protein, interacts with Rb and affects Rb transcriptional regulation. (PubMed id 11268000)1, 2, 9 Xia X.... Hamburger A.W. (J. Cell. Physiol. 2001)
    3. Interaction of the PA2G4 (EBP1) protein with ErbB-3 and regulation of this binding by heregulin. (PubMed id 10682683)1, 2, 9 Yoo J.Y....Hamburger A.W. (Br. J. Cancer 2000)
    4. Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling. (PubMed id 15583694)1, 2, 9 Zhang Y. and Hamburger A.W. (Br. J. Cancer 2005)
    5. Repression of E2F1-mediated transcription by the ErbB3 binding protein Ebp1 involves histone deacetylases. (PubMed id 12682367)1, 2, 9 Zhang Y.... Hamburger A.W. (Nucleic Acids Res. 2003)
    6. The crystal structure of Ebp1 reveals a methionine aminopeptidase fold as binding platform for multiple interactions. (PubMed id 17765895)1, 2, 9 Kowalinski E.... Sinning I. (FEBS Lett. 2007)
    7. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. EBP1 is a nucleolar growth-regulating protein that is part of pre- ribosomal ribonucleoprotein complexes. (PubMed id 15064750)1, 2 Squatrito M.... Draetta G.F. (Oncogene 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5036 HGNC: 8550 AceView: PA2G4 Ensembl:ENSG00000170515 euGenes: HUgn5036
    ECgene: PA2G4 H-InvDB: PA2G4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for PA2G4 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for PA2G4 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for PA2G4 gene:
    Search GeneIP for patents involving PA2G4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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