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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

P4HTM Gene

protein-coding   GIFtS: 49
GCID: GC03P049027

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
 Explore 9 diseases affiliated with
P4HTM via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for P4HTM    

Aliases
for P4HTM gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Prolyl 4-Hydroxylase, Transmembrane (Endoplasmic Reticulum)1 2     HIF-Prolyl Hydroxylase 42 3
P4H-TM1 2 3     FLJ202621
PH41 2 3     Hypoxia Inducible Factor Prolyl 4 Hydroxylase2
EGLN41 2     Hypoxia-Inducible Factor Prolyl 4-Hydroxylase2
HIFPH41 2     P4H With Transmembrane Domain2
PH-41 2     Proline 4-Hydroxylase2
PHD41 2     Prolyl Hydroxlase Domain-Containing 42
Hypoxia-Inducible Factor Prolyl Hydroxylase 42 3     Transmembrane Prolyl 4-Hydroxylase2
HIF-PH42 3     EC 1.14.11.-3
HPH-42 3     

External Ids:    HGNC: 288581   Entrez Gene: 546812   Ensembl: ENSG000001784677   OMIM: 6145845   UniProtKB: Q9NXG63   

Export aliases for P4HTM gene to outside databases

Previous GC identifer: GC03P049004


Summaries
for P4HTM gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for P4HTM:
The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that may
be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in
adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding different
isoforms have been identified. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: P4HTM_HUMAN, Q9NXG6
Function: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha
proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic
conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau
ubiquitination complex




Genomic Views
for P4HTM gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the P4HTM gene promoter:
         NF-1   AML1a   STAT5A   Evi-1   HEN1   POU2F1   POU2F1a   c-Myb   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: P4HTM promoter sequence
   Search SABiosciences Chromatin IP Primers for P4HTM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat P4HTM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31|3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

P4HTM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P4HTM gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P049027:  view genomic region     (about GC identifiers)

Start:
 49,027,319 bp from pter      End:
 49,044,587 bp from pter
Size:
 17,269 bases      Orientation:
 plus strand

Proteins
for P4HTM gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: P4HTM_HUMAN, Q9NXG6 (See protein sequence)
Recommended Name: Transmembrane prolyl 4-hydroxylase  
Size: 502 amino acids; 56661 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Cofactor: Ascorbate (By similarity)
Subunit: Homodimer
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein
Sequence caution: Sequence=AAH60321.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAA91045.1;
Type=Erroneous initiation; Sequence=CAD28518.2; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: Q6PAG6 Q8TCJ9 Q8WV55 Q96F22 Q9BW77
Alternative splicing: 3 isoforms:  Q9NXG6-1   Q9NXG6-2   Q9NXG6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for P4HTM: NX_Q9NXG6

Post-translational modifications:

  • Glycosylated1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NXG6

    • P4HTM Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_808807.2  NP_808808.1  

    ENSEMBL proteins: 
     ENSP00000373235   ENSP00000341422   ENSP00000398554  

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    Uscn Proteins for P4HTM

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--


    P4HTM for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for P4HTM

    Protein Domains /
    Families
    for P4HTM gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    P4HTM for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR006620 Pro_4_hyd_alph
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR018247 EF_Hand_1_Ca_BS
     IPR005123 Oxoglu/Fe-dep_dioxygenase

    Graphical View of Domain Structure for InterPro Entry Q9NXG6

    ProtoNet protein and cluster: Q9NXG6

    UniProtKB/Swiss-Prot: P4HTM_HUMAN, Q9NXG6
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 1 Fe2OG dioxygenase domain


    Function
    for P4HTM gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: P4HTM_HUMAN, Q9NXG6
    Function: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha
    proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic
    conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau
    ubiquitination complex
    Catalytic activity: An HIF alpha chain L-proline + 2-oxoglutarate + O(2) = An HIF alpha chain trans-4-hydroxy-L-proline
    + succinate + CO(2)
    Induction: By hypoxia in many cultured cell lines

    Enzyme Number (IUBMB): EC 1.14.11.-1

    miRNA
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    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0005509calcium ion binding IEA--
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen IEA--
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA--
    GO:0031418L-ascorbic acid binding IEA--


    P4HTM for ontologies           About GeneDecksing



    Pathways & Interactions
    for P4HTM gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for P4HTM

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for P4HTM (Q9NXG63 ENSP000003414224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD1DP158133, ENSP000003571534I2D: score=1 STRING: ENSP00000357153
    CELA3AENSP000002901224STRING: ENSP00000290122
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Drugs & Compounds
    for P4HTM gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    P4HTM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for P4HTM

    3 HMDB Compounds for P4HTM    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ascorbic acid(+)-ascorbate (see all 140)50-81-7--
    Hydroxyproline(2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid (see all 21)51-35-4--
    L-Proline(-)-(S)-Proline (see all 16)147-85-3--

    1 DrugBank Compound for P4HTM    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin CAscorbate (see all 6)50-81-7target--17139284 17016423

    5 Novoseek chemical compound relationships for P4HTM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oddd 89.2 1 16885164 (1)
    proline 67.9 14 8546682 (4), 12163023 (2), 2165882 (2), 1314568 (2) (see all 8)
    procollagen 56.6 2 2165882 (1), 8789253 (1)
    hydroxyproline 44.8 1 9566669 (1)
    oxygen 2.55 2 12163023 (1), 17725546 (1)

    Search CenterWatch for drugs/clinical trials and news about P4HTM 

    Transcripts
    for P4HTM gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for P4HTM gene (3 alternative transcripts): 
    NM_177938.2  NM_177939.2  NM_017732.3  

    Unigene Cluster for P4HTM:

    Prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
    Hs.654944  [show with all ESTs]
    Unigene Representative Sequence: NM_177938
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383729(uc003cvg.3) ENST00000343546(uc003cvh.3) ENST00000472301
    ENST00000484115 ENST00000475629 ENST00000444213 ENST00000468374 ENST00000486817
    ENST00000485210(uc010hkm.1) ENST00000491739 ENST00000472796

    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate P4HTM:
    hsa-miR-31
    SwitchGear 3'UTR luciferase reporter plasmid: P4HTM 3' UTR sequence
    Inhib. RNA
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK309082.1 AY198406.1 BC000580.1 BC011710.2 BC060321.1 

    24 DOTS entries:

    DT.95349477  DT.100802023  DT.97847888  DT.316345  DT.70104324  DT.100802029  DT.100704306  DT.95109644 
    DT.100844859  DT.120852521  DT.120852409  DT.95109635  DT.120852595  DT.120852492  DT.100640989  DT.100802035 
    DT.40127203  DT.120852692  DT.100802034  DT.432254  DT.75142172  DT.95184786  DT.120852661  DT.97847890 

    24/273 AceView cDNA sequences (see all 273):

    BU615872 AL535337 BM504103 BC011710 AW272627 BU625064 AI866020 AI254744 
    BM830210 CA313643 BQ005309 NM_177938 BQ575905 BM795062 CA422213 BU738220 
    CA776096 CK905458 AI075797 BM981182 CD518946 BX343780 BX101979 CN478501 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for P4HTM (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                    -           -                                               -                           
    SP2:                    -           -           -                                                               
    SP3:                    -     -     -                                                                           
    SP4:                                -                                                                           
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for P4HTM

    Expression
    for P4HTM gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    P4HTM expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTATTTATTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See P4HTM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for P4HTM

    SOURCE GeneReport for Unigene cluster: Hs.654944

    UniProtKB/Swiss-Prot: P4HTM_HUMAN, Q9NXG6
    Tissue specificity: Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta,
    kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts

        SABiosciences Custom PCR Arrays for P4HTM
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    In Situ
    Assay Products:     
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    Orthologs
    for P4HTM gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for P4HTM gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia P4htm1 , 5 prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)1, 5 86.32(n)1
    91.24(a)1    		   9 (59.52 cM)5
    744431  NM_028944.31  NP_083220.31 
     1085788265 
    chicken
    (Gallus gallus)    		 Aves LOC1008595831 transmembrane prolyl 4-hydroxylase-like 75.87(n)
    76.52(a)    		   100859583  XM_003642013.1  XP_003642061.1 
    lizard
    (Anolis carolinensis)    		 Reptilia P4HTM6
    		 --
    		 63(a)
    		 1 ↔ 1
    		 2(187767618-187813422)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7999301 transmembrane prolyl 4-hydroxylase-like 60.65(n)
    57.27(a)    		   799930  XM_001340198.1  XP_001340234.1 


    ENSEMBL Gene Tree for P4HTM (if available)
    TreeFam Gene Tree for P4HTM (if available) 

    Paralogs
    for P4HTM gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for P4HTM gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/196 NCBI SNPs in P4HTM are shown (see all 196)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1476355281,2
    		--49025542(+) GTGTAA/CGAATG 2 -- us2k10--------
    rs1828596091,2
    		--49025582(+) CAGATA/TTTATG 2 -- us2k10--------
    rs1159318801,2
    		F,--49025625(+) GGGCCG/AGTCGC 2 -- us2k11Minor allele frequency- A:0.06NA 120
    rs1870780631,2
    		--49025772(+) GGCACA/GTGCCT 2 -- us2k10--------
    rs1422418271,2
    		--49026037(+) TTGGTC/GTGGGT 2 -- us2k10--------
    rs1899802291,2
    		--49026160(+) AAAAAC/TATAAA 2 -- us2k10--------
    rs1822604931,2
    		--49026191(+) GGGCAC/TCTGTA 2 -- us2k10--------
    rs2012543691,2
    		--49026332(+) AAAAA-/TTATAAT 2 -- us2k10--------
    rs2019172651,2
    		--49026333(+) AAATT-/AAAA  
                ATAAT     		2 -- us2k10--------
    rs719792421,2
    		C--49026334(+) AATTA-/AAAA  
                TAATT     		2 -- us2k10--------

    HapMap Linkage Disequilibrium report for P4HTM (49027319 - 49044587 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for P4HTM: --

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for P4HTM gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    P4HTM for disorders           About GeneDecksing

    OMIM gene information: 614584    OMIM disorders: --

    9 diseases for P4HTM:    About MalaCards
    hypoxia    farber lipogranulomatosis    dermatofibrosarcoma protuberans    dermatofibrosarcoma
    lipogranulomatosis    laryngotracheitis    kaposi's sarcoma    keloids
    sarcoma

    1 disease from the University of Copenhagen DISEASES database for P4HTM:
    Laryngotracheitis

    Export disorders for P4HTM gene to outside databases

    Publications
    for P4HTM gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for P4HTM gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with P4HTM)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors. (PubMed id 12163023)1, 2, 3, 9 Oehme F.... Flamme I. (2002)
    2. An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha. (PubMed id 17726031)1, 2, 3 Koivunen P.... Myllyharju J. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    6. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    7. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)
    8. How many drug targets are there? (PubMed id 17139284)7 Overington J.P....Hopkins A.L. (2006)
    9. Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. (PubMed id 16154531)1 Hirota K. and Semenza G.L. (2005)
    10. The peptide-substrate-binding domain of collagen prolyl 4- hydroxylases is a tetratricopeptide repeat domain with functional aromatic residues. (PubMed id 15456751)1 Pekkala M....Myllyharju J. (2004)

    External Searches for P4HTM gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing P4HTM gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54681 HGNC: 28858 AceView: PH-4 Ensembl:ENSG00000178467 euGenes: HUgn54681
    ECgene: P4HTM H-InvDB: P4HTM

    Other Databases showing P4HTM gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing P4HTM gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for P4HTM Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for P4HTM gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for P4HTM gene:
    Search GeneIP for patents involving P4HTM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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