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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

P4HTM Gene

protein-coding   GIFtS: 49
GCID: GC03P049027

Prolyl 4-Hydroxylase, Transmembrane (Endoplasmic Reticulum)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Prolyl 4-Hydroxylase, Transmembrane (Endoplasmic Reticulum)1 2     EGLN42
Hypoxia Inducible Factor Prolyl 4 Hydroxylase1 2     HIFPH42
Prolyl Hydroxlase Domain-Containing 41 2     PH-42
Hypoxia-Inducible Factor Prolyl Hydroxylase 42 3     PHD42
HIF-PH42 3     Hypoxia-Inducible Factor Prolyl 4-Hydroxylase2
HPH-42 3     P4H With Transmembrane Domain2
P4H-TM2 3     Proline 4-Hydroxylase2
PH42 3     Transmembrane Prolyl 4-Hydroxylase2
HIF-Prolyl Hydroxylase 42 3     EC 1.14.11.-3

External Ids:    HGNC: 288581   Entrez Gene: 546812   Ensembl: ENSG000001784677   OMIM: 6145845   UniProtKB: Q9NXG63   

Export aliases for P4HTM gene to outside databases

Previous GC identifer: GC03P049004


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for P4HTM Gene:
The product of this gene belongs to the family of prolyl 4-hydroxylases. This protein is a prolyl hydroxylase that
may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. It plays a role in
adaptation to hypoxia and may be related to cellular oxygen sensing. Alternatively spliced variants encoding
different isoforms have been identified. (provided by RefSeq, Jul 2008)

GeneCards Summary for P4HTM Gene: 
P4HTM (prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)) is a protein-coding gene. Diseases associated with P4HTM include laryngotracheitis, and farber lipogranulomatosis. GO annotations related to this gene include oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen and calcium ion binding.

UniProtKB/Swiss-Prot: P4HTM_HUMAN, Q9NXG6
Function: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha
proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under
normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von
Hippel-Lindau ubiquitination complex




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the P4HTM gene promoter:
         NF-1   AML1a   STAT5A   Evi-1   HEN1   POU2F1   POU2F1a   c-Myb   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidP4HTM promoter sequence
   Search SABiosciences Chromatin IP Primers for P4HTM

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat P4HTM


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31|3p21.3   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

P4HTM Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P4HTM gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P049027:  view genomic region     (about GC identifiers)

Start:
49,027,319 bp from pter      End:
49,044,587 bp from pter
Size:
17,269 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: P4HTM_HUMAN, Q9NXG6 (See protein sequence)
Recommended Name: Transmembrane prolyl 4-hydroxylase  
Size: 502 amino acids; 56661 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Cofactor: Ascorbate (By similarity)
Subunit: Homodimer
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein
Sequence caution: Sequence=AAH60321.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAA91045.1;
Type=Erroneous initiation; Sequence=CAD28518.2; Type=Miscellaneous discrepancy; Note=Intron retention;
Secondary accessions: Q6PAG6 Q8TCJ9 Q8WV55 Q96F22 Q9BW77
Alternative splicing: 3 isoforms:  Q9NXG6-1   Q9NXG6-2   Q9NXG6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for P4HTM: NX_Q9NXG6

Explore proteomics data for P4HTM at MOPED 

Post-translational modifications:

  • UniProtKB: Glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NXG6

  • P4HTM Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    P4HTM Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_808807.2  NP_808808.1  

    ENSEMBL proteins: 
     ENSP00000373235   ENSP00000341422   ENSP00000398554  

    Human Recombinant Protein Products for P4HTM: 
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    Cloud-Clone Corp. Proteins for P4HTM 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    P4HTM for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR006620 Pro_4_hyd_alph
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS
     IPR005123 Oxoglu/Fe-dep_dioxygenase

    Graphical View of Domain Structure for InterPro Entry Q9NXG6

    ProtoNet protein and cluster: Q9NXG6

    UniProtKB/Swiss-Prot: P4HTM_HUMAN, Q9NXG6
    Similarity: Contains 2 EF-hand domains
    Similarity: Contains 1 Fe2OG dioxygenase domain


    P4HTM for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P4HTM_HUMAN, Q9NXG6
    Function: Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha
    proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under
    normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von
    Hippel-Lindau ubiquitination complex
    Catalytic activity: An HIF alpha chain L-proline + 2-oxoglutarate + O(2) = An HIF alpha chain
    trans-4-hydroxy-L-proline + succinate + CO(2)
    Induction: By hypoxia in many cultured cell lines

         Enzyme Number (IUBMB): EC 1.14.11.-1

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding IEA--
    GO:0005509calcium ion binding IEA--
    GO:0016491oxidoreductase activity ----
    GO:0016702oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ----
    GO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ----
         
    P4HTM for ontologies           About GeneDecksing


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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for P4HTM

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for P4HTM (Q9NXG63 ENSP000003414224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CD1DP158133, ENSP000003571534I2D: score=1 STRING: ENSP00000357153
    CELA3AENSP000002901224STRING: ENSP00000290122
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0055114oxidation-reduction process ----

    P4HTM for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    P4HTM for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for P4HTM

    3 HMDB Compounds for P4HTM    About this table
    CompoundSynonyms CAS #PubMed Ids
    Ascorbic acid(+)-ascorbate (see all 140)50-81-7--
    Hydroxyproline(2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid (see all 21)51-35-4--
    L-Proline(-)-(S)-Proline (see all 16)147-85-3--

    1 DrugBank Compound for P4HTM    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Vitamin CAscorbate (see all 6)50-81-7target--17139284 17016423

    5 Novoseek inferred chemical compound relationships for P4HTM gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oddd 89.2 1 16885164 (1)
    proline 67.9 14 8546682 (4), 12163023 (2), 2165882 (2), 1314568 (2) (see all 8)
    procollagen 56.6 2 2165882 (1), 8789253 (1)
    hydroxyproline 44.8 1 9566669 (1)
    oxygen 2.55 2 12163023 (1), 17725546 (1)

    Search CenterWatch for drugs/clinical trials and news about P4HTM

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for P4HTM gene (3 alternative transcripts): 
    NM_177938.2  NM_177939.2  NM_017732.3  

    Unigene Cluster for P4HTM:

    Prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
    Hs.654944  [show with all ESTs]
    Unigene Representative Sequence: NM_177938
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000383729(uc003cvg.3) ENST00000343546(uc003cvh.3) ENST00000472301
    ENST00000484115 ENST00000475629 ENST00000444213 ENST00000468374 ENST00000486817
    ENST00000485210(uc010hkm.1) ENST00000491739 ENST00000472796
    miRNA
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    Additional mRNA sequence: 

    AK309082.1 AY198406.1 BC000580.1 BC011710.2 BC060321.1 

    24 DOTS entries:

    DT.95349477  DT.100802023  DT.97847888  DT.316345  DT.70104324  DT.100802029  DT.100704306  DT.95109644 
    DT.100844859  DT.120852521  DT.120852409  DT.95109635  DT.120852595  DT.120852492  DT.100640989  DT.100802035 
    DT.40127203  DT.120852692  DT.100802034  DT.432254  DT.75142172  DT.95184786  DT.120852661  DT.97847890 

    24/273 AceView cDNA sequences (see all 273):

    CF453908 NM_177938 CB120274 BE314764 BQ636800 BM978092 BM691715 AA985464 
    CA390089 CD672751 AI866020 BM699861 CB306798 BX101979 BU615872 BQ478529 
    BM974297 CF264953 BX343780 BQ005309 AW272627 BM981182 BM795062 CN478501 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for P4HTM (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:                    -           -                                               -                           
    SP2:                    -           -           -                                                               
    SP3:                    -     -     -                                                                           
    SP4:                                -                                                                           
    SP5:                                                                                                            


    ECgene alternative splicing isoforms for P4HTM

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    P4HTM expression in normal human tissues (normalized intensities)      P4HTM embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATTTATTG
    P4HTM Expression
    About this image


    P4HTM expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
             bronchial epithelia   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             lung ; pneumocytes   

    See P4HTM Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for P4HTM

    SOURCE GeneReport for Unigene cluster: Hs.654944

    UniProtKB/Swiss-Prot: P4HTM_HUMAN, Q9NXG6
    Tissue specificity: Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain,
    placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P4HTM

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for P4HTM gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia P4htm1 , 5 prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)1, 5 86.32(n)1
    91.24(a)1
      9 (59.52 cM)5
    744431  NM_028944.31  NP_083220.31 
     1085788265 
    chicken
    (Gallus gallus)
    Aves LOC1008595831 transmembrane prolyl 4-hydroxylase-like 75.87(n)
    76.52(a)
      100859583  XM_003642013.1  XP_003642061.1 
    lizard
    (Anolis carolinensis)
    Reptilia P4HTM6
    Uncharacterized protein
    62(a)
    1 ↔ 1
    2(187767514-187813492)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7999301 transmembrane prolyl 4-hydroxylase-like 60.65(n)
    57.27(a)
      799930  XM_001340198.1  XP_001340234.1 


    ENSEMBL Gene Tree for P4HTM (if available)
    TreeFam Gene Tree for P4HTM (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/251 SNPs in P4HTM are shown (see all 251)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1476355281,2
    --49025542(+) GTGTAA/CGAATG 2 -- us2k10--------
    rs1828596091,2
    --49025582(+) CAGATA/TTTATG 2 -- us2k10--------
    rs1159318801,2
    C,F--49025625(+) GGGCCG/AGTCGC 2 -- us2k11Minor allele frequency- A:0.06NA 120
    rs1870780631,2
    --49025772(+) GGCACA/GTGCCT 2 -- us2k10--------
    rs1422418271,2
    C--49026037(+) TTGGTC/GTGGGT 2 -- us2k10--------
    rs1899802291,2
    --49026160(+) AAAAAC/TATAAA 2 -- us2k10--------
    rs1822604931,2
    --49026191(+) GGGCAC/TCTGTA 2 -- us2k10--------
    rs2012543691,2
    --49026332(+) AAAAA-/TTATAAT 2 -- us2k10--------
    rs2019172651,2
    C--49026333(+) AAATT-/AAAA  
            
    ATAAT
    2 -- us2k10--------
    rs126392861,2
    H--49026390(+) aattgC/Gcccgc 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for P4HTM (49027319 - 49044587 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for P4HTM:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv876764CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614584    OMIM disorders: --

    11 diseases for P4HTM:    About MalaCards
    laryngotracheitis    farber lipogranulomatosis    lipogranulomatosis    hypoxia
    hypertrophic scars    dermatofibrosarcoma protuberans    dermatofibrosarcoma    keloids
    kaposi's sarcoma    sarcoma    endotheliitis


    P4HTM for disorders           About GeneDecksing


    Export disorders for P4HTM gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for P4HTM gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with P4HTM)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors. (PubMed id 12163023)1, 2, 3, 9 Oehme F.... Flamme I. (2002)
    2. An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha. (PubMed id 17726031)1, 2, 3 Koivunen P.... Myllyharju J. (2007)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The Identification of Novel Proteins That Interact Wit h the GLP-1 Receptor and Restrain its Activity. (PubMed id 23864651)1 Huang X....Wheeler M.B. (2013)
    6. Why do cellular proteins linked to K63-polyubiquitin c hains not associate with proteasomes? (PubMed id 23314748)1 Nathan J.A....Goldberg A.L. (2013)
    7. Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins. (PubMed id 23284715)1 Kammula E.C....Willbold D. (2012)
    8. Human prolyl hydroxylase expression in uterine leiomyo ma during the menstrual cycle. (PubMed id 23241241)1 Iwahashi M....Ino K. (2012)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54681 HGNC: 28858 AceView: PH-4 Ensembl:ENSG00000178467 euGenes: HUgn54681
    ECgene: P4HTM H-InvDB: P4HTM

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for P4HTM Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for P4HTM gene:
    Search GeneIP for patents involving P4HTM

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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