Aliases for P4HA3 Gene
- Prolyl 4-Hydroxylase Subunit Alpha 3 2 3
- Prolyl 4-Hydroxylase, Alpha Polypeptide III 2 5
- EC 22.214.171.124 4 63
- Procollagen-Proline, 2-Oxoglutarate 4-Dioxygenase (Proline 4-Hydroxylase), Alpha Polypeptide III 2
- Procollagen-Proline,2-Oxoglutarate-4-Dioxygenase Subunit Alpha-3 4
- Collagen Prolyl 4-Hydroxylase Alpha(III) 2
- 4-PH Alpha-3 4
External Ids for P4HA3 Gene
Previous GeneCards Identifiers for P4HA3 Gene
This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed of two identical alpha subunits and two beta subunits. The encoded protein is one of several different types of alpha subunits and provides the major part of the catalytic site of the active enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of 4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized procollagen chains. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
GeneCards Summary for P4HA3 Gene
P4HA3 (Prolyl 4-Hydroxylase Subunit Alpha 3) is a Protein Coding gene. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include oxidoreductase activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is P4HA2.
UniProtKB/Swiss-Prot for P4HA3 Gene
Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.