V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

P4HA2 Gene

protein-coding GIFtS: 62

GC05M131556

prolyl 4-hydroxylase, alpha polypeptide II
(Previous names: procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
C-P4Halpha(II) ^¹, ²
EC 1.14.11.2 ^³
OTTHUMP00000065966 ^²
OTTHUMP00000065967 ^²
OTTHUMP00000065968 ^²
OTTHUMP00000065969 ^²

Descriptions
4-PH alpha 2 ^²
4-PH alpha-2 ^³
Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2 ^³
collagen prolyl 4-hydroxylase alpha(II) ^²
procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II ^¹, ²
prolyl 4-hydroxylase, alpha II subunit ^²
prolyl 4-hydroxylase, alpha polypeptide II ^²

External Ids
HGNC: 8547¹
Entrez Gene: 8974²
UniProtKB: O15460³
Ensembl: ENSG00000072682⁷

Search outside databases for aliases for P4HA2 gene

Previous GC identifers: GC05M131050 GC05M131975 GC05M131558 GC05M131604

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for P4HA2:

This gene encodes a component of prolyl 4-hydroxylase, a key enzyme in collagen synthesis composed

of two identical alpha subunits and two beta subunits. The encoded protein is one of several

different types of alpha subunits and provides the major part of the catalytic site of the active

enzyme. In collagen and related proteins, prolyl 4-hydroxylase catalyzes the formation of

4-hydroxyproline that is essential to the proper three-dimensional folding of newly synthesized

procollagen chains. Alternatively spliced transcript variants encoding different isoforms have

been described. [provided by RefSeq]

UniProtKB/Swiss-Prot: P4HA2_HUMAN, O15460

Function: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences

in collagens and other proteins

Gene Wiki entry for P4HA2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the P4HA2 gene

Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.1 HGNC cytogenetic band: 5q31

P4HA2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M131556: (about GC identifiers)

Start:	131,555,430 bp from pter
End:	131,591,455 bp from pter
Size:	36,026 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_034772.5

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: P4HA2_HUMAN, O15460 (See protein sequence)

Recommended Name: Prolyl 4-hydroxylase subunit alpha-2 precursor

Size: 535 amino acids; 60902 Da

Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)

Cofactor: Ascorbate (By similarity)

Subunit: Heterotetramer of two alpha-2 chains and two beta chains (the beta chain is the

multi-functional PDI)

Subcellular location: Endoplasmic reticulum lumen

Secondary accessions: Q8WWN0

Alternative splicing: 2 isoforms: O15460-1 O15460-2

REFSEQ proteins (5 alternative transcripts):

NP_001017973.1 NP_001017974.1 NP_001136070.1 NP_001136071.1 NP_004190.1

ENSEMBL proteins:

ENSP00000378593 ENSP00000166534 ENSP00000368379 ENSP00000384999 ENSP00000353772 ENSP00000368398

ENSP00000368394 ENSP00000351611

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (P4HA2)
	Human Recombinant Proteins from Abnova (P4HA2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005783	endoplasmic reticulum	IEA	--
GO:0005788	endoplasmic reticulum lumen	IEA	--

About this table

Antibodies for P4HA2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (P4HA2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for P4HA2

Assays for P4HA2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15460

ProtoNet protein and cluster: O15460

2 Blocks protein families:

IPB006620 Prolyl 4-hydroxylase

IPB013547 Prolyl 4-hydroxylase alpha-subunit

UniProtKB/Swiss-Prot: P4HA2_HUMAN, O15460

Similarity: Belongs to the P4HA family

Similarity: Contains 1 PKHD (prolyl/lysyl hydroxylase) domain

Similarity: Contains 1 TPR repeat

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P4HA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P4HA2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_004199

Applied Biosystems Silencer® siRNAs for P4HA2

Sigma-Aldrich siRNA and siRNA Panels for P4HA2

Sigma-Aldrich shRNA for P4HA2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for P4HA2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001017973
Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001017973
untagged cDNA clones in CMV expression vector (see all 5): NM_001017973

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004199

UniProtKB/Swiss-Prot: P4HA2_HUMAN, O15460

Function: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences

in collagens and other proteins

Catalytic activity: Procollagen L-proline + 2-oxoglutarate + O(2) = procollagen

trans-4-hydroxy-L-proline + succinate + CO(2)

Enzyme Number (IUBMB): EC 1.14.11.2

Genatlas biochemistry entry for P4HA2:

procollagen-proline,2-oxoglutarate 4-dioxygenase (prolyl-4-hydroxylase),alpha polypeptide,isoform

2,component of the heterodimer (alpha 2) 2,beta 2,type II,enzyme non inhibited by poly (L-proline)

1 MGI phenotypic allele

for P4ha2 (no phenotypes)

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004656	procollagen-proline 4-dioxygenase activity	TAS	9211872
GO:0005506	iron ion binding	IEA	--
GO:0005515	protein binding	IPI	14667819
GO:0009055	electron carrier activity	TAS	9211872
GO:0016491	oxidoreductase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for P4HA2 (Your Favorite Gene powered by Ingenuity)

Arginine and Proline Metabolism

GeneDecks P4HA2 for the pathways selected above

About GeneDecksing

5/19 Interacting proteins for P4HA2 (ENSP00000351611³ O15460^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 19 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ENSG00000206318	P48634¹^,²	EBI-348033, EBI-347545 MINT-62798 MINT-62722 MINT-62624
ENSG00000206427	P48634¹^,²	EBI-348033, EBI-347545 MINT-62798 MINT-62722 MINT-62624
BAT2	P48634¹^,²	EBI-348033, EBI-347545 MINT-62798 MINT-62722 MINT-62624 EBI-348033, EBI-347545 MINT-62798 MINT-62722 MINT-62624
BAT2	P48634¹^,²	EBI-348033, EBI-347545 MINT-62798 MINT-62722 MINT-62624 EBI-348033, EBI-347545 MINT-62798 MINT-62722 MINT-62624
P4HB	ENSP00000327801³	STRING (score=.957)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline	IEA	--
GO:0019538	protein metabolic process	IEA	--
GO:0055114	oxidation reduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for P4HA2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P4HA2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P4HA2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 5): NM_004199

Sigma-Aldrich siRNA and siRNA Panels for P4HA2

Sigma-Aldrich shRNA for P4HA2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001017973 NM_001017974 NM_001142598 NM_001142599 NM_004199

REFSEQ mRNAs for P4HA2 gene (5 alternative transcripts):

NM_001017973.1 NM_001017974.1 NM_001142598.1 NM_001142599.1 NM_004199.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001017973 NM_001017974 NM_001142598 NM_001142599 NM_004199

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NM_001017973
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NM_001017973
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_001017973

Additional cDNA sequence:

AY358970.1 BC017062.1 BC025960.1 BC035813.1 BX647924.1 U90441.1

19 DOTS entries:

DT.217263 DT.40106425 DT.100811842 DT.101984633 DT.95069941 DT.100756949 DT.120834278 DT.120834223

DT.208457 DT.97846687 DT.92434008 DT.100811845 DT.120834286 DT.95069939 DT.120834215 DT.120834221

DT.95147380 DT.422196 DT.95106346

24/282 AceView cDNA sequences (see all 282 ):

AL709983 AW952029 CA447642 D11983 AA375513 BQ233400 BQ219610 CA432106

BE670401 AU122034 BX370420 BP372517 BP375206 BP362906 F10703 AL544836

BM704593 AW664288 AL711125 AU280794 AA569099 AI359372 BF447278 NM_004199

highest scoring ESTs for P4HA2:

AI752379 AL701939 AL709983 AL710717 AL710826 AU280794 AY358970 BC025960 BC035813 BG252333

Unigene Cluster for P4HA2:

Prolyl 4-hydroxylase, alpha polypeptide II

Hs.519568 [show with all ESTs]

Unigene Representative Sequence: NM_004199

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for P4HA2 (see all 9 )

ExUns:	1	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18a	·	18b	^	19a	·
SP1:			-		-		-		-		-		-																												-		-				-
SP2:									-		-		-																												-		-				-
SP3:																																							-				-				-
SP4:			-		-						-		-
SP5:					-				-		-		-

ExUns:	19b	·	19c	·	19d
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for P4HA2

8 Ensembl transcripts including schematic representations:

ENST00000395164 ENST00000166534 ENST00000379086 ENST00000401867 ENST00000360568 ENST00000379104

ENST00000379100 ENST00000358760

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

P4HA2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for P4HA2

¹ / ² / ³

4 probe-sets matching P4HA2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
75910_at²^{, 3}	U95-E	1	1.00	1.00	0.94	0.99	AA142891	0.40	1.00	0.76	1
34390_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.01	U90441	0.80	1.00	0.91	1
202733_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004199	0.60	1.00	0.82	1
202733_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks P4HA2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTGTTTTTA

SOURCE GeneReport for Unigene cluster: Hs.519568
Expression variation in blood from EXPOLDB for P4HA2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for P4HA2 gene from 5/11 species (see all 11 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	P4HA2¹	--	prolyl 4-hydroxylase, alpha polypeptide II	89.99(n) 93.62(a)	474672 XM_855544.1 XP_860637.1
chimpanzee (Pan troglodytes)	P4HA2¹	--	prolyl 4-hydroxylase, alpha polypeptide II	97.56(n) 97.75(a)	462047 XM_001162222.1 XP_001162222.1
cow (Bos taurus)	P4HA2¹	--	prolyl 4-hydroxylase, alpha polypeptide II	89.94(n) 93.63(a)	507327 NM_001034293.1 NP_001029465.1
rat (Rattus norvegicus)	P4ha2¹	--	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline more	84.8(n) 91.56(a)	360526 XM_340798.3 XP_340799.3
mouse (Mus musculus)	P4ha2^{1, 5}	11 (29.20 cM)⁵	procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline more^{1, 5}	85.55(n)¹ 90.81(a)¹	18452¹ NM_011031.1¹ NP_035161.1¹ AA407196⁵ AJ314858⁵ (see all 17)

About this table Species with no ortholog for P4HA2

ENSEMBL Gene Tree for P4HA2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for P4HA2 gene

P4HA1² P4HA3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/169 NCBI SNPs in P4HA2 are shown (see all 169 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 82)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs246108^1,2	A,C,F	131591582(+)	`TCGCCG/ATCCTC`	3	--	ng3¹		1	EA	200
	rs157577^1,2	A,C,F	131591470(+)	`GCCTCC/GGGCCG`	3	--	ng3¹ ese³		2	EA	350
	rs3805685^1,2	C,F,H	131556052(-)	`TCAACA/CCTTGT`	3	--	ng5¹ ese³		9	EA EU WA NA	2224
	rs7702160^1,2	F,H	131555747(+)	`tctccA/Gaagtg`	3	--	ng5¹		4	EU EA WA	418
	rs3805684^1,2	F,H	131556135(-)	`ATCACC/ATTCAT`	3	--	ng5¹		5	EA EU WA	1904
--	rs17165772^1,2	F	131592211(-)	`ACCCAG/TTGTGC`	3	--	ng3¹		2	MN EA	356
	rs128738^1,2	A,C,F,H,O	131568774(+)	`ATCCTG/TTGGAA`	3	--	int¹		1	WA	120
	rs157578^1,2	A,C,F,H,O	131589221(+)	`GCCTCG/CGCCAC`	3	--	int¹		13	EA NA EU WA	1162
	rs156029^1,2	A,C,F,H,O	131560533(-)	`GTCTCC/TCTTGT`	3	--	int¹		12	EU EA WA NA	1056
	rs246107^1,2	A,C,F,H	131574567(+)	`ACTCTA/GAGGAA`	3	--	int¹ trp³		5	EA EU WA	1890

About this table

HapMap Linkage Disequilibrium images for P4HA2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600608

Human Genome Epidemiology Navigator: P4HA2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/17 PubMed articles for P4HA2 gene (see all 17 ):

Cloning of the human prolyl 4-hydroxylase alpha subunit isoform alpha(II) and characterization of the type II enzyme tetramer. The alpha(I) and alpha(II) subunits do not form a mixed alpha(I)alpha(II)beta2 tetramer. (PubMed id 9211872)^{2, 3, 4} Annunen P....Kivirikko K.I. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Characterization of the human and mouse genes for the alpha subunit of type II prolyl 4-hydroxylase. Identification of a previously unknown alternatively spliced exon and its expression in various tissues. (PubMed id 11606192)^{3, 4} Nokelainen M.... Myllyharju J. (2001)
Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease. (PubMed id 17213842)^{1, 3} Silverberg M.S....Daly M.J. (2007)
Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster. (PubMed id 19131452)³ Forton J.T....Hull J. (2009)
p53-mediated inhibition of angiogenesis through up-regulation of a collagen prolyl hydroxylase. (PubMed id 16917063)³ Teodoro J.G....Green M.R. (2006)
Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels. (PubMed id 16877351)³ Grimmer C....Pfander D. (2006)
The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases. (PubMed id 16885164)³ Koivunen P....Myllyharju J. (2006)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)³ Kimura K.... Sugano S. (2006)
Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region. (PubMed id 14667819)³ Lehner B....Sanderson C.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8974	HGNC: 8547	AceView: P4HA2	Ensembl:ENSG00000072682	euGenes: HUgn8974
ECgene: P4HA2	H-InvDB: P4HA2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for P4HA2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for P4HA2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for P4HA2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for P4HA2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for P4HA2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (P4HA2)
	Search for Antibodies
	Chimera RNAi (P4HA2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (P4HA2)
	Antibodies (P4HA2)

Search OriGene for P4HA2

Search Tocris compounds for P4HA2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for P4HA2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
P4HA2 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

P4HA2 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for P4HA2

Summaries
for P4HA2

Genomic Location
for P4HA2

Proteins
for P4HA2

Protein Domains/
Families
for P4HA2

Gene Function
for P4HA2

Pathways & Interactions
for P4HA2

Drugs & Compounds
for P4HA2

Transcripts
for P4HA2

Expression
for P4HA2

Orthologs
for P4HA2

Paralogs
for P4HA2

SNPs/Variants
for P4HA2

Disorders & Mutations
for P4HA2

Medical News
for P4HA2

Publications
for P4HA2

Search for P4HA2

Genome Databases showing P4HA2

Other Databases showing P4HA2

Specialized Databases showing P4HA2

Licensable Technologies
for P4HA2

Services
for P4HA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

P4HA2 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor P4HA2

Summariesfor P4HA2

Genomic Locationfor P4HA2

Proteinsfor P4HA2

Protein Domains/Familiesfor P4HA2

Gene Functionfor P4HA2

Pathways & Interactionsfor P4HA2

Drugs & Compoundsfor P4HA2

Transcriptsfor P4HA2

Expression for P4HA2

Orthologsfor P4HA2

Paralogsfor P4HA2

SNPs/Variantsfor P4HA2

Disorders & Mutationsfor P4HA2

Medical Newsfor P4HA2

Publicationsfor P4HA2

Search for P4HA2

Genome Databases showing P4HA2

Other Databases showing P4HA2

Specialized Databases showing P4HA2

Licensable Technologiesfor P4HA2

Servicesfor P4HA2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for P4HA2

Summaries
for P4HA2

Genomic Location
for P4HA2

Proteins
for P4HA2

Protein Domains/
Families
for P4HA2

Gene Function
for P4HA2

Pathways & Interactions
for P4HA2

Drugs & Compounds
for P4HA2

Transcripts
for P4HA2

Expression
for P4HA2

Orthologs
for P4HA2

Paralogs
for P4HA2

SNPs/Variants
for P4HA2

Disorders & Mutations
for P4HA2

Medical News
for P4HA2

Publications
for P4HA2

Licensable Technologies
for P4HA2

Services
for P4HA2