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Aliases for P3H4 Gene

Aliases for P3H4 Gene

  • Prolyl 3-Hydroxylase Family Member 4 (Non-Enzymatic) 2 3 5
  • Nucleolar Autoantigen (55kD) 2 3
  • Nucleolar Autoantigen No55 3 4
  • Leprecan-Like Protein 4 3 4
  • Leprecan-Like 4 2 3
  • LEPREL4 3 4
  • NOL55 3 4
  • SC65 3 4
  • Prolyl 3-Hydroxylase Family Member 4 4
  • Rat Synaptonemal Complex Protein 2
  • Nucleolar Autoantigen, 55kDa 3
  • NO55 3

External Ids for P3H4 Gene

Previous HGNC Symbols for P3H4 Gene

  • LEPREL4

Summaries for P3H4 Gene

Entrez Gene Summary for P3H4 Gene

  • This nucleolar protein was first characterized because it was an autoantigen in cases on interstitial cystitis. The protein, with a predicted molecular weight of 50 kDa, appears to be localized in the particulate compartment of the interphase nucleolus, with a distribution distinct from that of nucleolar protein B23. During mitosis it is associated with chromosomes. [provided by RefSeq, Jul 2008]

GeneCards Summary for P3H4 Gene

P3H4 (Prolyl 3-Hydroxylase Family Member 4 (Non-Enzymatic)) is a Protein Coding gene. An important paralog of this gene is CRTAP.

Gene Wiki entry for P3H4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P3H4 Gene

Genomics for P3H4 Gene

Regulatory Elements for P3H4 Gene

Promoters for P3H4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around P3H4 on UCSC Golden Path with GeneCards custom track

Genomic Location for P3H4 Gene

Chromosome:
17
Start:
41,801,947 bp from pter
End:
41,812,616 bp from pter
Size:
10,670 bases
Orientation:
Minus strand

Genomic View for P3H4 Gene

Genes around P3H4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P3H4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P3H4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P3H4 Gene

Proteins for P3H4 Gene

  • Protein details for P3H4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92791-SC65_HUMAN
    Recommended name:
    Synaptonemal complex protein SC65
    Protein Accession:
    Q92791
    Secondary Accessions:
    • Q53GI6
    • Q9H4F6

    Protein attributes for P3H4 Gene

    Size:
    437 amino acids
    Molecular mass:
    50381 Da
    Quaternary structure:
    No Data Available

neXtProt entry for P3H4 Gene

Proteomics data for P3H4 Gene at MOPED

Post-translational modifications for P3H4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for P3H4 Gene

No data available for DME Specific Peptides for P3H4 Gene

Domains & Families for P3H4 Gene

Protein Domains for P3H4 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for P3H4 Gene

Graphical View of Domain Structure for InterPro Entry

Q92791

UniProtKB/Swiss-Prot:

SC65_HUMAN :
  • Belongs to the leprecan family.
Family:
  • Belongs to the leprecan family.
genes like me logo Genes that share domains with P3H4: view

No data available for Gene Families for P3H4 Gene

Function for P3H4 Gene

Phenotypes for P3H4 Gene

GenomeRNAi human phenotypes for P3H4:
genes like me logo Genes that share phenotypes with P3H4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for P3H4

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for P3H4 Gene

Localization for P3H4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P3H4 Gene

Nucleus, nucleolus. Chromosome. Note=Localized uniformly throughout the granular component of the nucleolus and on the surface of chromosomes during mitosis.

Gene Ontology (GO) - Cellular Components for P3H4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000795 synaptonemal complex IEA --
genes like me logo Genes that share ontologies with P3H4: view

No data available for Subcellular locations from COMPARTMENTS for P3H4 Gene

Pathways & Interactions for P3H4 Gene

SuperPathways for P3H4 Gene

No Data Available

Interacting Proteins for P3H4 Gene

Gene Ontology (GO) - Biological Process for P3H4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for P3H4 Gene

Drugs & Compounds for P3H4 Gene

No Compound Related Data Available

Transcripts for P3H4 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for P3H4 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10
SP1: - - - -
SP2: - - - -
SP3:
SP4:
SP5: - - -
SP6:

Relevant External Links for P3H4 Gene

GeneLoc Exon Structure for
P3H4
ECgene alternative splicing isoforms for
P3H4

Expression for P3H4 Gene

mRNA expression in normal human tissues for P3H4 Gene

Protein differential expression in normal tissues from HIPED for P3H4 Gene

This gene is overexpressed in Bone (50.1) and Fetal ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for P3H4 Gene



genes like me logo Genes that share expression patterns with P3H4: view

Protein tissue co-expression partners for P3H4 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for P3H4 Gene

Orthologs for P3H4 Gene

This gene was present in the common ancestor of animals.

Orthologs for P3H4 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LEPREL4 35
  • 90.21 (n)
  • 91.89 (a)
LEPREL4 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Leprel4 35
  • 88.03 (n)
  • 92.49 (a)
P3h4 16
Leprel4 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LEPREL4 35
  • 99.11 (n)
  • 98.67 (a)
LEPREL4 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Leprel4 35
  • 88.02 (n)
  • 91.15 (a)
cow
(Bos Taurus)
Mammalia LEPREL4 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LEPREL4 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LEPREL4 36
  • 60 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC430099 35
  • 73.74 (n)
  • 67.68 (a)
LEPREL4 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LEPREL4 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia leprel4 35
  • 64.7 (n)
  • 62.32 (a)
Str.16255 35
zebrafish
(Danio rerio)
Actinopterygii leprel4 35
  • 58.33 (n)
  • 56.25 (a)
leprel4 36
  • 53 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y73F8A.26 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToMany
Species with no ortholog for P3H4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for P3H4 Gene

ENSEMBL:
Gene Tree for P3H4 (if available)
TreeFam:
Gene Tree for P3H4 (if available)

Paralogs for P3H4 Gene

Paralogs for P3H4 Gene

genes like me logo Genes that share paralogs with P3H4: view

Variants for P3H4 Gene

Sequence variations from dbSNP and Humsavar for P3H4 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_020417 -
rs1061843 -- 41,802,092(-) TGGAC(A/G)AGGAG utr-variant-3-prime
rs1065029 -- 41,802,937(-) ACACC(C/G)CTCAA reference, missense, utr-variant-3-prime
rs2304493 -- 41,809,916(-) CAGAG(A/C/G)TTGGA intron-variant
rs2304494 -- 41,806,699(-) CCCCT(A/G)GTGGT intron-variant

Variation tolerance for P3H4 Gene

Residual Variation Intolerance Score: 31.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.98; 89.94% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P3H4 Gene

HapMap Linkage Disequilibrium report
P3H4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for P3H4 Gene

Disorders for P3H4 Gene

Relevant External Links for P3H4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
P3H4

No disorders were found for P3H4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for P3H4 Gene

Publications for P3H4 Gene

  1. cDNA cloning and characterization of a novel nucleolar protein. (PMID: 8862517) Ochs R.L. … Tan E.M. (Mol. Biol. Cell 1996) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Identification and characterization of a new autoimmune protein in membranous nephropathy by immunoscreening of a renal cDNA library. (PMID: 23144993) Cavazzini F. … Cappelli G. (PLoS ONE 2012) 3
  4. Proteomic and biochemical analysis of 14-3-3-binding proteins during C2-ceramide-induced apoptosis. (PMID: 20618440) Pozuelo-Rubio M. (FEBS J. 2010) 3
  5. Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC). (PMID: 16396496) Foster L.J. … Klip A. (J. Proteome Res. 2006) 3

Products for P3H4 Gene

Sources for P3H4 Gene

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