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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

P2RY8 Gene

protein-coding   GIFtS: 51
GCID: GC0XM001625

Purinergic Receptor P2Y, G-Protein Coupled, 8

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Purinergic Receptor P2Y, G-Protein Coupled, 81 2
P2Y82 3
G-Protein Coupled Purinergic Receptor P2Y82
P2Y Purinoceptor 82

External Ids:    HGNC: 155241   Entrez Gene: 2865302   Ensembl: ENSG000001821627   OMIM: 3005255   UniProtKB: Q86VZ13   

Export aliases for P2RY8 gene to outside databases

Previous GC identifers: GC00U990860 GC0XM001162 GC0XM001226 GC0YM001625


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for P2RY8 Gene:
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially
activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells,
and is located on both chromosomes X and Y. (provided by RefSeq, Jul 2008)

GeneCards Summary for P2RY8 Gene: 
P2RY8 (purinergic receptor P2Y, G-protein coupled, 8) is a protein-coding gene. Diseases associated with P2RY8 include follicular lymphoma, and acute lymphoblastic leukemia, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors). GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is FFAR3.

UniProtKB/Swiss-Prot: P2RY8_HUMAN, Q86VZ1
Function: Probable receptor for purines coupled to G-proteins

summary for P2RY8 Gene:
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine
nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13
and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10
receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4
receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13
and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades
including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They
have diverse physiological roles including regulation of platelet aggregation, muscle contraction,
neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NT_167196.1  NC_000024.9  NT_167204.1  NC_018934.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the P2RY8 gene promoter:
         CREB   POU3F1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidP2RY8 promoter sequence
   Search SABiosciences Chromatin IP Primers for P2RY8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat P2RY8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.33; Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.33 and Yp11.3

P2RY8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P2RY8 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM001625:  view genomic region     (about GC identifiers)

Start:
1,581,465 bp from pter      End:
1,656,037 bp from pter
Size:
74,573 bases      Orientation:
minus strand

1 alternative location:
ChrY- 1,531,465-1,606,037     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: P2RY8_HUMAN, Q86VZ1 (See protein sequence)
Recommended Name: P2Y purinoceptor 8  
Size: 359 amino acids; 40635 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes

Explore the universe of human proteins at neXtProt for P2RY8: NX_Q86VZ1

Explore proteomics data for P2RY8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86VZ1

  • P2RY8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    P2RY8 Protein Expression
    REFSEQ proteins: NP_835230.1  
    ENSEMBL proteins: 
     ENSP00000370697  

    Human Recombinant Protein Products for P2RY8: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for P2RY8 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral to membrane IEA--

    P2RY8 for ontologies           About GeneDecksing



    P2RY8 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    P2R: Purinergic receptors
    P2RY: GPCR / Class A : Purinergic receptors, P2Y
    PAR1: Pseudoautosomal regions / PAR1

    IUPHAR Guide to PHARMACOLOGY protein family classification: P2RY8 
    Class A Orphans

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002286 purinergic_P2Y_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q86VZ1

    ProtoNet protein and cluster: Q86VZ1

    UniProtKB/Swiss-Prot: P2RY8_HUMAN, Q86VZ1
    Similarity: Belongs to the G-protein coupled receptor 1 family


    P2RY8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P2RY8_HUMAN, Q86VZ1
    Function: Probable receptor for purines coupled to G-proteins
    Induction: Down-regulated during granulocytic regulation

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0045028G-protein coupled purinergic nucleotide receptor activity IEA--
         
    P2RY8 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for P2RY8:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for P2RY8 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for P2RY8 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Neuroactive ligand-receptor interaction0.37

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1         Kegg Pathway  (Kegg details for P2RY8):
        Neuroactive ligand-receptor interaction


    P2RY8 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for P2RY8

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    P2RY8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for P2RY8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MRS 2365Highly potent and selective P2Y1 agonist[436847-09-5]
    alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist[7292-42-4]
    UTPgammaS trisodium saltSelective P2Y2/4 agonist[1266569-94-1]
    MRS 2500 tetraammonium saltExtremely potent and selective P2Y1 antagonist[630103-23-0]
    MRS 2179 tetrasodium saltSelective P2Y1 antagonist[101204-49-3]

    Search CenterWatch for drugs/clinical trials and news about P2RY8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for P2RY8 gene: 
    NM_178129.4  

    Unigene Cluster for P2RY8:

    Purinergic receptor P2Y, G-protein coupled, 8
    Hs.111377  [show with all ESTs]
    Unigene Representative Sequence: NM_178129
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381297(uc004cpz.2) ENST00000460672
    miRNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat P2RY8
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    Additional mRNA sequence: 

    AK092956.1 AK126147.1 AL833184.1 BC012792.2 BC043610.1 BX647292.1 

    6 DOTS entries:

    DT.443483  DT.86851724  DT.100000159  DT.121277632  DT.121277638  DT.86859088 

    24/65 AceView cDNA sequences (see all 65):

    BQ066374 AA631604 NM_178129 AA767124 BC012792 BF878641 CF136189 BQ708284 
    AA280154 CF137338 AW589281 AI936272 BG057809 AA259034 AW503945 BX647292 
    AW512198 AA258128 BG106666 AA280155 AW515841 AA262104 BC043610 AI476104 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    P2RY8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    P2RY8 Expression
    About this image


    See P2RY8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for P2RY8

    SOURCE GeneReport for Unigene cluster: Hs.111377

    UniProtKB/Swiss-Prot: P2RY8_HUMAN, Q86VZ1
    Tissue specificity: Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and
    lung. Not detected in brain

        SABiosciences Expression via Pathway-Focused PCR Array including P2RY8: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for P2RY8 gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia P2RY81 purinergic receptor P2Y, G-protein coupled, 8 81.22(n)
    78.87(a)
      491711  XM_548831.3  XP_548831.3 
    chicken
    (Gallus gallus)
    Aves P2RY81 purinergic receptor P2Y, G-protein coupled, 8 61.61(n)
    60.11(a)
      418665  NM_001008679.1  NP_001008679.1 
    lizard
    (Anolis carolinensis)
    Reptilia P2RY86
    --
    Uncharacterized protein
    56(a)
    34(a)
    1 ↔ 1
    possible ortholog
    3(113295909-113296970)
    3(113323258-113324292)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5664971 novel 7 transmembrane receptor (rhodopsin family) domain more 58.1(n)
    52.98(a)
      566497  XM_689767.2  XP_694859.2 


    ENSEMBL Gene Tree for P2RY8 (if available)
    TreeFam Gene Tree for P2RY8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for P2RY8 gene
    FFAR32  GPR42  GPR682  GPR652  F2RL12  FFAR22  F2RL22  GPR1322  
    FFAR12  GPR422  F2RL32  F2R2  
    18/19 SIMAP similar genes for P2RY8 using alignment to 1 protein entry:     P2RY8_HUMAN(see all similar genes):
    F2R    LPAR4    F2RL1    F2RL2    F2RL3    LPAR6
    P2RY5    FFAR2    CYSLTR1    GPR183    P2RY1    AGTR2
    OXGR1    FFAR3    GPR17    GPR174    CYSLTR2    KPG_011

    P2RY8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 10/19 variations for P2RY8 (see all 19):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1361e201CNV Deletion23290073
    esv2665018CNV Deletion23128226
    esv2667421CNV Deletion23128226
    esv2739728CNV Deletion23290073
    esv2660373CNV Deletion23128226
    esv2676182CNV Deletion23128226
    esv2739727CNV Deletion23290073
    esv2739721CNV Deletion23290073
    esv2739724CNV Deletion23290073
    esv2739731CNV Deletion23290073


    Locus Specific Mutation Databases (LSDB): P2RY8
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for P2RY8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300525    OMIM disorders: --

    6 diseases for P2RY8:    About MalaCards
    follicular lymphoma    acute lymphoblastic leukemia    down syndrome    lymphoblastic leukemia
    mental retardation    leukemia

    2 diseases from the University of Copenhagen DISEASES database for P2RY8:
    Down syndrome     Lymphoblastic leukemia

    P2RY8 for disorders           About GeneDecksing


    Export disorders for P2RY8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for P2RY8 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with P2RY8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PubMed id 11004484)1, 2, 3 Adrian K.... Ogilvie A. (2000)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males. (PubMed id 15466006)1, 2 Cantagrel V.... Villard L. (2004)
    5. Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening. (PubMed id 17487742)1, 9 Fujiwara S....Mano H. (2007)
    6. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    7. Small sizes and indolent evolutionary dynamics challen ge the potential role of P2RY8-CRLF2-harboring clones as main relapse-driving fo rce in childhood ALL. (PubMed id 23091296)1 Morak M....Panzer-Grumayer R. (2012)
    8. Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF 2 over-expression in children with intermediate risk B-cell precursor acute lymp hoblastic leukemia. (PubMed id 22484421)1 Palmi C....Te Kronnie G. (2012)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Presence of the P2RY8-CRLF2 rearrangement is associat ed with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol. (PubMed id 20378752)1 Cario G....Stanulla M. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 286530 HGNC: 15524 AceView: P2RY8 Ensembl:ENSG00000182162 euGenes: HUgn286530
    ECgene: P2RY8 Kegg: 286530 H-InvDB: P2RY8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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