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P2RY8 Gene

protein-coding   GIFtS: 50
GCID: GC0XM001625

Purinergic Receptor P2Y, G-Protein Coupled, 8

  See P2RY8-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Purinergic Receptor P2Y, G-Protein Coupled, 81 2
P2Y82 3 5
G-Protein Coupled Purinergic Receptor P2Y82
P2Y Purinoceptor 82

External Ids:    HGNC: 155241   Entrez Gene: 2865302   Ensembl: ENSG000001821627   OMIM: 3005255   UniProtKB: Q86VZ13   

Export aliases for P2RY8 gene to outside databases

Previous GC identifers: GC00U990860 GC0XM001162 GC0XM001226 GC0YM001625


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for P2RY8 Gene:
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially
activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells,
and is located on both chromosomes X and Y. (provided by RefSeq, Jul 2008)

GeneCards Summary for P2RY8 Gene:
P2RY8 (purinergic receptor P2Y, G-protein coupled, 8) is a protein-coding gene. Diseases associated with P2RY8 include follicular lymphoma. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is FFAR3.

UniProtKB/Swiss-Prot: P2RY8_HUMAN, Q86VZ1
Function: Probable receptor for purines coupled to G-proteins

summary for P2RY8 Gene:
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine
nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13
and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10
receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4
receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13
and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades
including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They
have diverse physiological roles including regulation of platelet aggregation, muscle contraction,
neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000023.10  NT_187358.1  NC_000024.9  NT_167201.2  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the P2RY8 gene promoter:
         CREB   POU3F1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidP2RY8 promoter sequence
   Search Chromatin IP Primers for P2RY8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat P2RY8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp22.33; Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.33 and Yp11.3

P2RY8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P2RY8 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM001625:  view genomic region     (about GC identifiers)

Start:
1,581,465 bp from pter      End:
1,656,037 bp from pter
Size:
74,573 bases      Orientation:
minus strand

1 alternative location:
ChrY- 1,531,465-1,606,037     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: P2RY8_HUMAN, Q86VZ1 (See protein sequence)
Recommended Name: P2Y purinoceptor 8  
Size: 359 amino acids; 40635 Da
Miscellaneous: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y
chromosomes

Explore the universe of human proteins at neXtProt for P2RY8: NX_Q86VZ1

Explore proteomics data for P2RY8 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys132
  • Glycosylation2 at Asn5, Asn11
  • Modification sites at PhosphoSitePlus

  • See P2RY8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_835230.1  
    ENSEMBL proteins: 
     ENSP00000370697  

    P2RY8 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    P2R: Purinergic receptors
    P2RY: GPCR / Class A : Purinergic receptors, P2Y
    PAR1: Pseudoautosomal regions / PAR1

    IUPHAR Guide to PHARMACOLOGY protein family classification: P2RY8
    Class A Orphans

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR027669 P2Y8_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q86VZ1

    ProtoNet protein and cluster: Q86VZ1

    UniProtKB/Swiss-Prot: P2RY8_HUMAN, Q86VZ1
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with P2RY8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P2RY8_HUMAN, Q86VZ1
    Function: Probable receptor for purines coupled to G-proteins
    Induction: Down-regulated during granulocytic regulation

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0045028G-protein coupled purinergic nucleotide receptor activity IEA--
         
    Find genes that share ontologies with P2RY8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for P2RY8:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for P2RY8
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P2RY8_HUMAN, Q86VZ1: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with P2RY8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for P2RY8 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36


    Find genes that share SuperPaths with P2RY8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for P2RY8):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY8: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for P2RY8

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with P2RY8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Compounds for P2RY8 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MRS 2365Highly potent and selective P2Y1 agonist[436847-09-5]
    alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist[7292-42-4]
    UTPgammaS trisodium saltSelective P2Y2/4 agonist[1266569-94-1]
    MRS 2500 tetraammonium saltExtremely potent and selective P2Y1 antagonist[630103-23-0]
    MRS 2179 tetrasodium saltSelective P2Y1 antagonist[101204-49-3]



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for P2RY8 gene: 
    NM_178129.4  

    Unigene Cluster for P2RY8:

    Purinergic receptor P2Y, G-protein coupled, 8
    Hs.111377  [show with all ESTs]
    Unigene Representative Sequence: NM_178129
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000381297(uc004cpz.2) ENST00000460672
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      QuantiFast Probe-based Assays in human, mouse, rat P2RY8

    Additional mRNA sequence: 

    AK092956.1 AK126147.1 AL833184.1 BC012792.2 BC043610.1 BX647292.1 

    6 DOTS entries:

    DT.443483  DT.86851724  DT.100000159  DT.121277632  DT.121277638  DT.86859088 

    Selected AceView cDNA sequences (see all 65):

    AA767124 AA631604 NM_178129 CF136189 BC012792 BQ066374 BF878641 AL833184 
    AA280154 BQ058381 AI476104 AW503945 AA804402 AK126147 BG057809 BQ054816 
    BF878601 BQ708284 CF137338 AW515841 BX110844 AW512198 BC043610 BX342547 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    P2RY8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    P2RY8 Expression
    About this image

    P2RY8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    P2RY8 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.111377

    UniProtKB/Swiss-Prot: P2RY8_HUMAN, Q86VZ1
    Tissue specificity: Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and
    lung. Not detected in brain

        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY8: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for P2RY8 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia P2RY81 purinergic receptor P2Y, G-protein coupled, 8 81.22(n)
    78.87(a)
      491711  XM_005642223.1  XP_005642280.1 
    chicken
    (Gallus gallus)
    Aves P2RY81 purinergic receptor P2Y, G-protein coupled, 8 61.7(n)
    60.11(a)
      418665  NM_001008679.1  NP_001008679.1 
    lizard
    (Anolis carolinensis)
    Reptilia P2RY86
    purinergic receptor P2Y, G-protein coupled, 8
    57(a)
    1 ↔ 1
    3(113295909-113296970)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004871941 P2Y purinoceptor 8-like 52.94(n)
    52.94(a)
      100487194  XM_002933616.2  XP_002933662.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5664971 novel 7 transmembrane receptor (rhodopsin family) domain more 58.1(n)
    52.98(a)
      566497  XM_689767.3  XP_694859.3 


    ENSEMBL Gene Tree for P2RY8 (if available)
    TreeFam Gene Tree for P2RY8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for P2RY8 gene
    FFAR32  GPR42  GPR682  GPR652  F2RL12  FFAR22  F2RL22  GPR1322  
    FFAR12  GPR422  F2RL32  F2R2  
    18 SIMAP similar genes for P2RY8 using alignment to 1 protein entry:     P2RY8_HUMAN:
    F2R    LPAR4    F2RL1    F2RL2    F2RL3    LPAR6
    FFAR2    CYSLTR1    GPR183    P2RY1    AGTR2    OXGR1
    FFAR3    GPR17    GPR174    CYSLTR2    KPG_011    P2RY10

    Find genes that share paralogs with P2RY8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for P2RY8 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1361e201CNV Deletion23290073
    esv2665018CNV Deletion23128226
    esv2667421CNV Deletion23128226
    esv2739728CNV Deletion23290073
    esv2660373CNV Deletion23128226
    esv2676182CNV Deletion23128226
    esv2739727CNV Deletion23290073
    esv2739721CNV Deletion23290073
    esv2739724CNV Deletion23290073
    esv2739731CNV Deletion23290073

    Locus Specific Mutation Databases (LSDB): P2RY8

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300525    OMIM disorders: --

    1 disease for P2RY8:    
    About MalaCards
    follicular lymphoma

    2 diseases from the University of Copenhagen DISEASES database for P2RY8:
    Down syndrome     Lymphoblastic leukemia

    Find genes that share disorders with P2RY8           About GenesLikeMe


    Export disorders for P2RY8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for P2RY8 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with P2RY8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PubMed id 11004484)1, 2, 3 Adrian K.... Ogilvie A. (Biochim. Biophys. Acta 2000)
    2. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males. (PubMed id 15466006)1, 2 Cantagrel V.... Villard L. (J. Med. Genet. 2004)
    5. Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening. (PubMed id 17487742)1, 9 Fujiwara S....Mano H. (amp 2007)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. Small sizes and indolent evolutionary dynamics challenge the potential role of P2RY8-CRLF2-harboring clones as main relapse-driving force in childhood ALL. (PubMed id 23091296)1 Morak M....Panzer-GrA1mayer R. (Blood 2012)
    8. Poor prognosis for P2RY8-CRLF2 fusion but not for CRLF2 over-expression in children with intermediate risk B-cell precursor acute lymphoblastic leukemia. (PubMed id 22484421)1 Palmi C....Te Kronnie G. (Leukemia 2012)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non-high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol. (PubMed id 20378752)1 Cario G....Stanulla M. (Blood 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 286530 HGNC: 15524 AceView: P2RY8 Ensembl:ENSG00000182162 euGenes: HUgn286530
    ECgene: P2RY8 Kegg: 286530 H-InvDB: P2RY8

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for P2RY8 Pharmacogenomics, SNPs, Pathways

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