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P2RY8 Gene

protein-coding   GIFtS: 49

GC0XM001625
purinergic receptor P2Y, G-protein coupled, 8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for P2RY8

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
MGC50878 2
OTTHUMP00000022830 2
P2Y8 1, 2, 3
Descriptions
G-protein coupled purinergic receptor P2Y8 2
purinergic receptor P2Y, G-protein coupled, 8 2
External Ids
HGNC: 155241
Entrez Gene: 2865302
UniProtKB: Q86VZ13
Ensembl: ENSG000001821627
Search outside databases for aliases for P2RY8 gene

Previous GC identifers: GC00U990860 GC0XM001162 GC0XM001226 GC0YM001625

Summaries
for P2RY8

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for P2RY8:
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are
preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed
in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq]

UniProtKB/Swiss-Prot: P2RY8_HUMAN, Q86VZ1
Function: Probable receptor for purines coupled to G-proteins

Gene Wiki entry for P2RY8

Genomic Location
for P2RY8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the P2RY8 gene  

Entrez Gene cytogenetic band: Xp22.33; Yp11.3   Ensembl cytogenetic band:  Xp22.33   HGNC cytogenetic band: Xp22.33 and Yp11.3

P2RY8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM001625:     (about GC identifiers)

Start:
 1,541,465 bp from pter
End:
 1,616,000 bp from pter
Size:
 74,536 bases
Orientation:
 minus strand

1 alternative location:
ChrY- 1,541,465-1,616,000     
RefSeq DNA sequence:
NC_000023.9  NC_000024.8  NT_033330.7  NT_113972.1  

Proteins
for P2RY8

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: P2RY8_HUMAN, Q86VZ1 (See protein sequence)
Recommended Name: P2Y purinoceptor 8  
Size: 359 amino acids; 40635 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: The gene encoding for this protein is located in the pseudoautosomal region 1 (PAR1)
of X and Y chromosomes

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_835230.1  

    ENSEMBL proteins: 
    ENSP00000370697 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (P2Y8)
    Human Recombinant Proteins from Abnova (P2RY8)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for P2RY8: 
    Browse Antibodies Central at Invitrogen
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    Sigma-Aldrich Antibodies for P2RY8
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    Antibodies from Abcam (P2Y8), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (P2RY8)
    Novus Biologicals Antibody for P2RY8

    Assays for P2RY8: 
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    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for P2RY8

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_supfam
     IPR000276 7TM_GPCR_Rhodpsn
     IPR002286 P2_purnocptor


       GeneDecks  P2RY8 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q86VZ1

    ProtoNet protein and cluster: Q86VZ1

    UniProtKB/Swiss-Prot: P2RY8_HUMAN, Q86VZ1
    Similarity: Belongs to the G-protein coupled receptor 1 family

    Gene Function
    for P2RY8

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (P2RY8)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (P2RY8)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178129

                  Applied Biosystems Silencer® siRNAs for P2RY8

                  Sigma-Aldrich siRNA and siRNA Panels for P2RY8  
                         Sigma-Aldrich shRNA Panels and shRNA for P2RY8  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for P2RY8
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_178129
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_178129
                                     untagged cDNA clone in CMV expression vector: NM_178129 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_178129

    UniProtKB/Swiss-Prot: P2RY8_HUMAN, Q86VZ1
    Function: Probable receptor for purines coupled to G-proteins
    Induction: Down-regulated during granulocytic regulation

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0004930 G-protein coupled receptor activity IEA--
    GO:0045028 purinergic nucleotide receptor activity, G-protein coupled IEA--
    About this table

    Pathways & Interactions
    for P2RY8

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Kegg Pathway  (Kegg details for P2RY8):
     hsa04080 Neuroactive ligand-receptor interaction

       GeneDecks  P2RY8 for the pathways selected above  
    About GeneDecksing

    1 Interacting protein for P2RY8 (ENSP000003706973) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KIAA2022ENSP000003625673STRING (score=.948)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165 signal transduction IEA--
    GO:0007186 G-protein coupled receptor protein signaling pathway IEA--
    About this table

    Drugs & Compounds
    for P2RY8

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Sigma-Aldrich Small Molecules for P2RY8:
    Antagonist Agonist

    Compounds for P2RY8 available from Tocris Bioscience
    CompoundAction CAS number
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    2-Methylthioadenosine triphosphate tetrasodium saltP2 purinergic agonist[43170-89-4]
    PPADS tetrasodium saltP2 purinergic antagonist[149017-66-3]
    About this table



    Transcripts
    for P2RY8

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (P2RY8)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (P2RY8)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_178129

                  Sigma-Aldrich siRNA and siRNA Panels for P2RY8  
                         Sigma-Aldrich shRNA Panels and shRNA for P2RY8  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_178129  

    REFSEQ mRNAs for P2RY8 gene: 

    NM_178129.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_178129  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_178129
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_178129
                                     untagged cDNA clone in CMV expression vector: NM_178129 

    Additional cDNA sequence: 

    AK092956.1 AK126147.1 AL833184.1 BC012792.2 BC043610.1 BX647292.1 

    6 DOTS entries:

    DT.443483  DT.86851724  DT.100000159  DT.121277632  DT.121277638  DT.86859088 

    24/65 AceView cDNA sequences (see all 65 ):

    BC012792 AA767124 BF878641 AA631604 NM_178129 CF136189 BQ066374 BQ708284 
    BX110844 BX342547 AA259034 AI936272 BC043610 AW503945 AA280155 AW512198 
    BG057809 AA262104 BQ058381 AW589281 AK092956 AW515841 AA742612 AA258128 

    highest scoring ESTs for P2RY8:

    AA259034 AA262104 AA280155 AA742612 AA767124 AA804402 AA804531 AI436587 AI796395 AI936272 

    Unigene Cluster for P2RY8:

    Purinergic receptor P2Y, G-protein coupled, 8
    Hs.111377  [show with all ESTs]
    Unigene Representative Sequence: NM_178129


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000381297  

    Expression
    for P2RY8

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    P2RY8 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for P2RY8

    1 / 2 / 3

    3 probe-sets matching P2RY8 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    56976_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI436587 0.80 1.00 0.91 1

    		229686_at2, 3 U133-B 1 1.00 1.00 -- -- AI436587 0.80 1.00 0.91 1

    		229686_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  P2RY8 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.111377

    UniProtKB/Swiss-Prot: P2RY8_HUMAN, Q86VZ1
    Tissue specificity: Barely detectable in normal blood leukocytes. Weaker expression was seen in
    heart, kidney and lung. Not detected in brain

    Orthologs
    for P2RY8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for P2RY8 gene from 4 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 P2RY81   -- purinergic receptor P2Y, G-protein coupled, 8 81.22(n)
    78.87(a)    		 491711  XM_548831.2  XP_548831.2 
    chimpanzee
    (Pan troglodytes)    		 P2RY81   -- purinergic receptor P2Y, G-protein coupled, 8 99.26(n)
    99.16(a)    		 751053  XM_001175457.1  XP_001175457.1 
    chicken
    (Gallus gallus)    		 P2RY81   -- purinergic receptor P2Y, G-protein coupled, 8 61.61(n)
    60.11(a)    		 418665  NM_001008679.1  NP_001008679.1 
    zebrafish
    (Danio rerio)    		 LOC5664971   -- similar to novel 7 transmembrane receptor (rhodopsin more 58.1(n)
    52.98(a)    		 566497  XM_689767.2  XP_694859.2 
    About this table        Species with no ortholog for P2RY8

    ENSEMBL Gene Tree for P2RY8

    Paralogs
    for P2RY8

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for P2RY8 gene
    GPR182  F2RL12  F2RL32  F2R2  F2RL22  

    SNPs/Variants
    for P2RY8

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

    		  --

    Disorders & Mutations
    for P2RY8

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 300525

    Medical News
    for P2RY8

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for P2RY8

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		8 PubMed articles for P2RY8 gene:

    Search for P2RY8

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing P2RY8

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 286530 HGNC: 15524 AceView: P2RY8 Ensembl:ENSG00000182162 euGenes: HUgn286530
    ECgene: P2RY8 H-InvDB: P2RY8

    Other Databases showing P2RY8

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing P2RY8

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for P2RY8

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for P2RY8

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for P2RY8:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



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     Predesigned and custom siRNAs for P2RY8 Antibodies for P2RY8
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for P2RY8 Small molecules for P2RY8
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Recombinant Proteins
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     Search OriGene for P2RY8
     Tocris compounds for P2RY8




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for P2RY8

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