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Aliases for P2RY8 Gene

Aliases for P2RY8 Gene

  • Purinergic Receptor P2Y8 2 3 5
  • Purinergic Receptor P2Y, G-Protein Coupled, 8 2 3
  • P2Y8 3 4
  • G-Protein Coupled Purinergic Receptor P2Y8 3
  • P2Y Purinoceptor 8 3

External Ids for P2RY8 Gene

Previous GeneCards Identifiers for P2RY8 Gene

  • GC00U990860
  • GC0XM001162
  • GC0XM001226
  • GC0YM001625
  • GC0XM001625

Summaries for P2RY8 Gene

Entrez Gene Summary for P2RY8 Gene

  • The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene is moderately expressed in undifferentiated HL60 cells, and is located on both chromosomes X and Y. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY8 Gene

P2RY8 (Purinergic Receptor P2Y8) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is F2RL1.

UniProtKB/Swiss-Prot for P2RY8 Gene

  • Probable receptor for purines coupled to G-proteins.

Tocris Summary for P2RY8 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY8 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY8 Gene

Genomics for P2RY8 Gene

Regulatory Elements for P2RY8 Gene

Enhancers for P2RY8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF001470 1.2 FANTOM5 Ensembl 22.5 +66.0 66005 1.8 HDGF ATF1 ARID4B DMAP1 YY1 GLIS2 CREM SP3 CBFB CEBPB P2RY8 AKAP17A ASMTL ASMT CSF2RA
GH0XF001500 1.3 FANTOM5 Ensembl 16.3 +34.2 34206 5.4 HDGF PKNOX1 ATF1 CREB3L1 ZNF48 ZNF121 ELK1 GATA2 ZNF207 TBX21 P2RY8 AKAP17A CSF2RA IL3RA ASMTL ASMT CRLF2 SLC25A6
GH0XF001491 0.9 FANTOM5 16.2 +45.4 45358 0.3 HDGF TBP ESRRA MXI1 PKNOX1 NFRKB SIN3A IRF3 RFX5 POLR2A P2RY8 ASMTL AKAP17A ASMT
GH0XF001525 0.5 FANTOM5 28.2 +11.9 11945 0.2 ZNF366 TARDBP IKZF1 ZNF24 P2RY8 ASMTL AKAP17A ASMT CSF2RA
GH0XF001493 0.7 Ensembl 14.2 +43.4 43420 1.4 HDGF TBP PKNOX1 TRIM22 EBF1 RELA ZNF366 SMARCA4 POLR2A ZNF512 P2RY8 ASMTL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around P2RY8 on UCSC Golden Path with GeneCards custom track

Promoters for P2RY8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001555738 1306 3201 HDGF PKNOX1 ATF1 WRNIP1 ZFP64 SIN3A ARID4B MCM3 JUNB REST

Genomic Location for P2RY8 Gene

Chromosome:
X
Start:
1,462,572 bp from pter
End:
1,537,506 bp from pter
Size:
74,935 bases
Orientation:
Minus strand

Genomic View for P2RY8 Gene

Genes around P2RY8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY8 Gene

Proteins for P2RY8 Gene

  • Protein details for P2RY8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VZ1-P2RY8_HUMAN
    Recommended name:
    P2Y purinoceptor 8
    Protein Accession:
    Q86VZ1

    Protein attributes for P2RY8 Gene

    Size:
    359 amino acids
    Molecular mass:
    40635 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

neXtProt entry for P2RY8 Gene

Post-translational modifications for P2RY8 Gene

  • Ubiquitination at Lys 132
  • Glycosylation at Asn 5 and Asn 11
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for P2RY8 Gene

Domains & Families for P2RY8 Gene

Protein Domains for P2RY8 Gene

Suggested Antigen Peptide Sequences for P2RY8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VZ1

UniProtKB/Swiss-Prot:

P2RY8_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY8: view

Function for P2RY8 Gene

Molecular function for P2RY8 Gene

UniProtKB/Swiss-Prot Function:
Probable receptor for purines coupled to G-proteins.
UniProtKB/Swiss-Prot Induction:
Down-regulated during granulocytic regulation.

Gene Ontology (GO) - Molecular Function for P2RY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY8: view
genes like me logo Genes that share phenotypes with P2RY8: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for P2RY8

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for P2RY8 Gene

Localization for P2RY8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY8 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY8 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for P2RY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with P2RY8: view

Pathways & Interactions for P2RY8 Gene

genes like me logo Genes that share pathways with P2RY8: view

Pathways by source for P2RY8 Gene

1 KEGG pathway for P2RY8 Gene

Interacting Proteins for P2RY8 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000370697%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000370697 Q86VZ1-P2RY8_HUMAN for P2RY8 Gene via STRING IID

Gene Ontology (GO) - Biological Process for P2RY8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0035025 positive regulation of Rho protein signal transduction IBA --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA --
genes like me logo Genes that share ontologies with P2RY8: view

No data available for SIGNOR curated interactions for P2RY8 Gene

Drugs & Compounds for P2RY8 Gene

(3) Drugs for P2RY8 Gene - From: DGIdb and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MC-1 Investigational Pharma 0
2-Methylthioadenosine diphosphate trisodium salt Pharma Potent agonist for P2Y1, P2Y12 and P2Y13 0
MRS 2500 tetraammonium salt Pharma Extremely potent and selective P2Y1 antagonist 0

(3) Additional Compounds for P2RY8 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
AR-C 118925XX
216657-60-2
PPTN hydrochloride
SAR 216471 hydrochloride
1279829-64-9

(5) Tocris Compounds for P2RY8 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
AR-C 118925XX Selective, competitive P2Y2 receptor antagonist 216657-60-2
MRS 2500 tetraammonium salt Extremely potent and selective P2Y1 antagonist 630103-23-0
PPTN hydrochloride High affinity and selective P2Y14 antagonist
SAR 216471 hydrochloride Potent P2Y12 antagonist; orally available 1279829-64-9
genes like me logo Genes that share compounds with P2RY8: view

Transcripts for P2RY8 Gene

Unigene Clusters for P2RY8 Gene

Purinergic receptor P2Y, G-protein coupled, 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for P2RY8

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY8 Gene

No ASD Table

Relevant External Links for P2RY8 Gene

GeneLoc Exon Structure for
P2RY8
ECgene alternative splicing isoforms for
P2RY8

Expression for P2RY8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for P2RY8 Gene

mRNA differential expression in normal tissues according to GTEx for P2RY8 Gene

This gene is overexpressed in Whole Blood (x12.5) and Spleen (x4.5).

Protein differential expression in normal tissues from HIPED for P2RY8 Gene

This gene is overexpressed in Monocytes (27.4), CD8 Tcells (15.2), CD4 Tcells (12.3), and Blymphocyte (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for P2RY8 Gene



Protein tissue co-expression partners for P2RY8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of P2RY8 Gene:

P2RY8

SOURCE GeneReport for Unigene cluster for P2RY8 Gene:

Hs.111377

mRNA Expression by UniProt/SwissProt for P2RY8 Gene:

Q86VZ1-P2RY8_HUMAN
Tissue specificity: Barely detectable in normal blood leukocytes. Weaker expression was seen in heart, kidney and lung. Not detected in brain.
genes like me logo Genes that share expression patterns with P2RY8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for P2RY8 Gene

Orthologs for P2RY8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY8 34 35
  • 99.26 (n)
cow
(Bos Taurus)
Mammalia P2RY8 34 35
  • 82.57 (n)
dog
(Canis familiaris)
Mammalia P2RY8 34 35
  • 81.22 (n)
oppossum
(Monodelphis domestica)
Mammalia P2RY8 35
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia P2RY8 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves P2RY8 34 35
  • 61.7 (n)
lizard
(Anolis carolinensis)
Reptilia P2RY8 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100487194 34
  • 52.94 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC566497 34
  • 58.1 (n)
p2ry8 35
  • 50 (a)
OneToOne
Species where no ortholog for P2RY8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY8 Gene

ENSEMBL:
Gene Tree for P2RY8 (if available)
TreeFam:
Gene Tree for P2RY8 (if available)

Paralogs for P2RY8 Gene

Paralogs for P2RY8 Gene

(18) SIMAP similar genes for P2RY8 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with P2RY8: view

Variants for P2RY8 Gene

Sequence variations from dbSNP and Humsavar for P2RY8 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10552339 -- 1,480,394(+) CCGGG(-/TTT)TTTTT intron-variant
rs10563406 -- 1,535,727(+) CACAC(-/AG)ACACA intron-variant
rs10657765 -- 1,504,315(+) GTGTC(-/AA)AAAAA intron-variant
rs10700341 -- 1,497,639(+) GTGAC(-/AA)GAGTA intron-variant
rs10715183 -- 1,480,297(+) CTTTC(-/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for P2RY8 Gene

Variant ID Type Subtype PubMed ID
nsv1141659 CNV duplication 24896259
nsv1141660 CNV duplication 24896259
nsv1146517 CNV duplication 26484159
nsv1151816 CNV duplication 26484159
nsv1151885 CNV duplication 26484159
nsv1153109 CNV duplication 26484159
nsv510811 CNV deletion 20534489
nsv1132748 CNV duplication 24896259
nsv1132747 CNV duplication 24896259
nsv1119381 CNV duplication 24896259
nsv1115920 CNV duplication 24896259
nsv1077214 CNV deletion 25765185
esv3558489 CNV deletion 23714750
esv3558487 CNV deletion 23714750
esv29996 CNV loss 17803354
esv2739731 CNV deletion 23290073
esv2739728 CNV deletion 23290073
esv2739727 CNV deletion 23290073
esv2739726 CNV deletion 23290073
esv2739724 CNV deletion 23290073
esv2739722 CNV deletion 23290073
esv2739721 CNV deletion 23290073
esv2676182 CNV deletion 23128226
esv2674649 CNV deletion 23128226
esv2667421 CNV deletion 23128226
esv2665018 CNV deletion 23128226
esv2662997 CNV deletion 23128226
esv2660373 CNV deletion 23128226
esv2294449 CNV deletion 18987734
dgv1304e201 CNV deletion 23290073
dgv1303e201 CNV deletion 23290073

Variation tolerance for P2RY8 Gene

Residual Variation Intolerance Score: 11.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.95; 74.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RY8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
P2RY8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY8 Gene

Disorders for P2RY8 Gene

Relevant External Links for P2RY8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
P2RY8

No disorders were found for P2RY8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for P2RY8 Gene

Publications for P2RY8 Gene

  1. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PMID: 11004484) Adrian K. … Ogilvie A. (Biochim. Biophys. Acta 2000) 2 3 4 64
  2. Transforming activity of purinergic receptor P2Y, G protein coupled, 8 revealed by retroviral expression screening. (PMID: 17487742) Fujiwara S. … Mano H. (Leuk. Lymphoma 2007) 3 22 64
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  4. Disruption of a new X linked gene highly expressed in brain in a family with two mentally retarded males. (PMID: 15466006) Cantagrel V. … Villard L. (J. Med. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for P2RY8 Gene

Sources for P2RY8 Gene

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