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P2RY6 Gene

protein-coding   GIFtS: 66
GCID: GC11P072975

Pyrimidinergic Receptor P2Y, G-Protein Coupled, 6

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pyrimidinergic Receptor P2Y, G-Protein Coupled, 61 2
P2Y62 3 5
G-Coupled Nucleotide Receptor2
P2 Purinoceptor2
P2Y Purinoceptor 62
P2Y6 Receptor2

External Ids:    HGNC: 85431   Entrez Gene: 50312   Ensembl: ENSG000001716317   OMIM: 6024515   UniProtKB: Q150773   

Export aliases for P2RY6 gene to outside databases

Previous GC identifers: GC11P075241 GC11P074515 GC11P073198 GC11P072701 GC11P072653 GC11P069270


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for P2RY6 Gene:
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides
and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several
receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine
and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially
responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory
responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
(provided by RefSeq, Mar 2013)

GeneCards Summary for P2RY6 Gene:
P2RY6 (pyrimidinergic receptor P2Y, G-protein coupled, 6) is a protein-coding gene. Diseases associated with P2RY6 include congestive heart failure, and insulinoma. GO annotations related to this gene include G-protein coupled receptor activity and UDP-activated nucleotide receptor activity. An important paralog of this gene is OXGR1.

UniProtKB/Swiss-Prot: P2RY6_HUMAN, Q15077
Function: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins
which activate a phosphatidylinositol-calcium second messenger system

summary for P2RY6 Gene:
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine
nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13
and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10
receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4
receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13
and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades
including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They
have diverse physiological roles including regulation of platelet aggregation, muscle contraction,
neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the P2RY6 gene promoter:
         Egr-2   Spz1   Hand1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidP2RY6 promoter sequence
   Search Chromatin IP Primers for P2RY6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat P2RY6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.5

P2RY6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P2RY6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P072975:  view genomic region     (about GC identifiers)

Start:
72,975,550 bp from pter      End:
73,009,664 bp from pter
Size:
34,115 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: P2RY6_HUMAN, Q15077 (See protein sequence)
Recommended Name: P2Y purinoceptor 6  
Size: 328 amino acids; 36429 Da
1 PDB 3D structure from and Proteopedia for P2RY6:
2B6R (3D)    
Secondary accessions: Q15754

Explore the universe of human proteins at neXtProt for P2RY6: NX_Q15077

Explore proteomics data for P2RY6 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn5

  • See P2RY6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001264133.1  NP_001264134.1  NP_001264135.1  NP_001264136.1  NP_001264137.1  NP_789766.1  NP_789767.1  NP_789768.1  

    ENSEMBL proteins: 
     ENSP00000443427   ENSP00000445652   ENSP00000309771   ENSP00000377217   ENSP00000441079  
     ENSP00000377216   ENSP00000442551   ENSP00000377215   ENSP00000442509   ENSP00000440770  
     ENSP00000442990  
    Reactome Protein details: Q15077

    P2RY6 Human Recombinant Protein Products:

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    Novus Biologicals P2RY6 Proteins
    Novus Biologicals P2RY6 Lysates
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    Cloud-Clone Corp. Proteins for P2RY6

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    Cloud-Clone Corp. CLIAs for P2RY6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    P2R: Purinergic receptors
    P2RY: GPCR / Class A : Purinergic receptors, P2Y

    IUPHAR Guide to PHARMACOLOGY protein family classification: P2Y6 receptor
    P2Y receptors

    3 InterPro protein domains:
     IPR001973 P2Y6_rcpt
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q15077

    ProtoNet protein and cluster: Q15077

    2 Blocks protein domains:
    IPB001973 P2Y6 purinoceptor signature
    IPB002286 P2 purinoceptor signature


    UniProtKB/Swiss-Prot: P2RY6_HUMAN, Q15077
    Similarity: Belongs to the G-protein coupled receptor 1 family


    P2RY6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P2RY6_HUMAN, Q15077
    Function: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins
    which activate a phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for P2RY6:
    purinoceptor P2Y type 6,group 5,metabotropic,expressed in bone,placenta,osteoblastic and brain cell
    lines,predominantly responding to ATP,G protein coupled receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity TAS8670200
    GO:0045028G-protein coupled purinergic nucleotide receptor activity IEA--
    GO:0045029UDP-activated nucleotide receptor activity IEA--
         
    P2RY6 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for P2RY6:
     Increased gamma-H2AX phosphory 

         7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for P2ry6):
     cardiovascular system  cellular  hematopoietic system  immune system  muscle 
     no phenotypic analysis  respiratory system 

    P2RY6 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out P2ry6tm1.1Brob for P2RY6

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for P2RY6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for P2RY6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for P2RY6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for P2RY6

    miRNA
    Products:
        
    miRTarBase miRNAs that target P2RY6:
    hsa-mir-26b-5p (MIRT028885)

    Block miRNA regulation of human, mouse, rat P2RY6 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate P2RY6:
    hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidP2RY6 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for P2RY6
    Predesigned siRNA for gene silencing in human, mouse, rat P2RY6

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): P2RY6 (NM_176798)
    Sino Biological Human cDNA Clone for P2RY6
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for P2RY6
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P2RY6_HUMAN, Q15077: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8670200
    GO:0016021integral component of membrane ----
    GO:0016323basolateral plasma membrane IEA--
    GO:0016324apical plasma membrane IEA--

    P2RY6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for P2RY6 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Nucleotide-like (purinergic) receptors
    Nucleotide GPCRs0.00
    P2Y receptors0.00
    Nucleotide-like (purinergic) receptors
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Development Angiotensin activation of ERK
    Signal transduction IP3 signaling0.43

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for P2RY6
        P2Y Receptor Signaling

    1 GeneGo (Thomson Reuters) Pathway for P2RY6
        Signal transduction IP3 signaling

    2 BioSystems Pathways for P2RY6
        GPCRs, Class A Rhodopsin-like
    Nucleotide GPCRs


    2 Reactome Pathways for P2RY6
        P2Y receptors
    G alpha (q) signalling events


    1 Kegg Pathway  (Kegg details for P2RY6):
        Neuroactive ligand-receptor interaction


    P2RY6 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY6: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for P2RY6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for P2RY6 (Q150773 ENSP000003097714) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRTAP4-12Q9BQ663I2D: score=1 
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    AGTR1ENSP000002734304STRING: ENSP00000273430
    BDKRB2ENSP000003077134STRING: ENSP00000307713
    CASRENSP000002961544STRING: ENSP00000296154
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway TAS8670200
    GO:0014911positive regulation of smooth muscle cell migration IEA--
    GO:0030321transepithelial chloride transport IEA--

    P2RY6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for P2RY6 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MRS 2365Highly potent and selective P2Y1 agonist[436847-09-5]
    alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist[7292-42-4]
    UTPgammaS trisodium saltSelective P2Y2/4 agonist[1266569-94-1]
    MRS 2500 tetraammonium saltExtremely potent and selective P2Y1 antagonist[630103-23-0]
    MRS 2179 tetrasodium saltSelective P2Y1 antagonist[101204-49-3]

    1 HMDB Compound for P2RY6    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for P2RY6 (P2Y6 receptor) (see all 16)    About this table
    LigandTypeActionAffinityPubmed IDs
    compound 18a [PMID:22901672]
    AgonistAgonist8.122901672
    MRS2957
    AgonistAgonist7.920446735
    5-iodoUDP
    AgonistFull agonist7.8216942026
    UDP-beta-S
    AgonistFull agonist7.5516475938
    MRS2578
    AntagonistAntagonist7.415081875
    3-phenacyl-UDP
    AgonistFull agonist7.217125260
    MRS2567
    AntagonistAntagonist6.915081875
    INS48823
    AgonistFull agonist6.916475938
    Up3U
    AgonistFull agonist6.716475938
    UDP
    AgonistFull agonist6.58670200

    Selected Novoseek inferred chemical compound relationships for P2RY6 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    udpbetas 87.8 3 12737633 (2), 16543499 (1)
    uridine diphosphate 84.1 14 16543499 (2), 9840612 (2), 16942026 (2), 12603858 (1) (see all 7)
    bzatp 80 1 16373435 (1)
    alpha,beta methylene atp 74.7 1 12691958 (1)
    adpbetas 72.5 1 19836435 (1)
    adp 72.4 7 8700127 (1), 9886992 (1), 12691958 (1), 19836435 (1) (see all 6)
    atp 71.9 15 8700127 (2), 9704019 (1), 16475938 (1), 18635403 (1) (see all 10)
    ppads 71.1 2 17702822 (1)
    uridine 63.2 7 8700127 (3), 11114308 (2), 18506388 (1)
    udpglucose 58.4 1 16475938 (1)



    P2RY6 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for P2RY6 gene (9 alternative transcripts): 
    NM_001277204.1  NM_001277205.1  NM_001277206.1  NM_001277207.1  NM_001277208.1  NM_176796.2  NM_176797.2  NM_176798.2  
    NM_004154.3  

    Unigene Cluster for P2RY6:

    Pyrimidinergic receptor P2Y, G-protein coupled, 6
    Hs.16362  [show with all ESTs]
    Unigene Representative Sequence: NM_004154
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000540342 ENST00000542092 ENST00000349767 ENST00000393592 ENST00000544437
    ENST00000393591 ENST00000540124 ENST00000393590(uc001otm.3 uc001otn.3 uc001otq.3 uc001otr.3 uc001ots.3)
    ENST00000536225 ENST00000535931 ENST00000538328
    miRNA
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    hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidP2RY6 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat P2RY6
      QuantiTect SYBR Green Assays in human, mouse, rat P2RY6
      QuantiFast Probe-based Assays in human, mouse, rat P2RY6

    Additional mRNA sequence: 

    AF007891.1 AF007892.1 AF007893.1 AF218005.1 AF498920.1 AK311529.1 BC000571.2 BC009391.2 
    BT006771.1 U52464.1 X97058.1 

    9 DOTS entries:

    DT.440885  DT.95271557  DT.95271559  DT.100820481  DT.86852961  DT.100820471  DT.100820482  DT.120679380 
    DT.95271558 

    Selected AceView cDNA sequences (see all 112):

    BX396836 CR626706 BF769476 CR605588 BM918491 NM_176797 BX397649 AF218005 
    AF498920 AL525099 CB242913 CR624871 BX337204 AI473230 NM_176796 CR598765 
    X97058 BC009391 CR597500 CR617080 BU147495 BX280241 BX381745 CR612681 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for P2RY6 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
    SP1:                    -     -     -     -           -                                                   
    SP2:                    -     -     -                 -                                                   
    SP3:                          -     -                 -                                                   
    SP4:                                                  -                                                   
    SP5:                    -     -     -                 -     -                                             


    ECgene alternative splicing isoforms for P2RY6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    P2RY6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGAGCTGGG
    P2RY6 Expression
    About this image


    P2RY6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
     
     Placenta (Extraembryonic Tissues)
    P2RY6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    P2RY6 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.16362
        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY6: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for P2RY6 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia P2ry61 , 5 pyrimidinergic receptor P2Y, G-protein coupled, 61, 5 84.15(n)1
    87.12(a)1
      7 (54.46 cM)5
    2335711  NM_183168.21  NP_898991.11 
     1009376345 
    chicken
    (Gallus gallus)
    Aves P2RY61 pyrimidinergic receptor P2Y, G-protein coupled, 6 70.2(n)
    63.67(a)
      396114  NM_205195.1  NP_990526.1 
    lizard
    (Anolis carolinensis)
    Reptilia P2RY66
    pyrimidinergic receptor P2Y, G-protein coupled, 6
    60(a)
    1 ↔ 1
    GL343298.1(283065-284039)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5660991 P2Y purinoceptor 3-like 60.85(n)
    61.59(a)
      566099  XM_689367.5  XP_694459.2 


    ENSEMBL Gene Tree for P2RY6 (if available)
    TreeFam Gene Tree for P2RY6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for P2RY6 gene
    OXGR12  P2RY42  GPR172  P2RY12  GPR1742  LPAR62  LPAR52  CYSLTR12  
    GPR1832  LPAR42  CYSLTR22  P2RY22  SUCNR12  P2RY102  PTAFR2  
    Selected SIMAP similar genes for P2RY6 using alignment to 4 protein entries:     P2RY6_HUMAN (see all proteins) (see all similar genes):
    GPR18    P2RY4    F2RL1    FPR2    CCR5    P2RY2
    CXCR2    CCR2    CCR7    GPR1    GPR17    LTB4R
    F2RL3    GPR183    LPAR4    P2RY1    CX3CR1    CYSLTR2

    P2RY6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for P2RY6 (see all 749)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs112357021,2
    C,F,A,H--72973594(+) gttcaT/Cgtctt 3 -- us2k118Minor allele frequency- C:0.14NS EA NA WA CSA 1744
    rs1434978271,2
    --72973615(+) TTCTGC/TTAGGT 4 -- us2k10--------
    rs1846638171,2
    --72973709(+) CCAGTC/TGGTAG 4 -- us2k10--------
    rs1509321751,2
    --72973801(+) TTTACA/GATTTT 4 -- us2k10--------
    rs1891381241,2
    --72973836(+) AAAAAG/TTGTTC 4 -- us2k10--------
    rs1419215271,2
    --72973918(+) CCCAGA/GGAGAA 4 -- us2k10--------
    rs1166387691,2
    F--72973992(+) AGGGAA/GGAGTG 4 -- us2k11Minor allele frequency- G:0.02WA 118
    rs1469088481,2
    --72974010(+) GAGGAA/GGAACA 4 -- us2k10--------
    rs1815712661,2
    --72974163(+) ATAGGA/TGGGCA 4 -- us2k10--------
    rs1393207761,2
    --72974272(+) GCCTAA/GGATTC 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for P2RY6 (72975550 - 73009664 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for P2RY6:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv387CNV Insertion18451855
    nsv520665CNV Loss19592680
    nsv832208CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing P2RY6
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602451    OMIM disorders: --

    15 diseases for P2RY6:    
    About MalaCards
    congestive heart failure    insulinoma    inflammatory bowel disease    astrocytoma
    neuroblastoma    myocardial infarction    pancreatitis    retinitis
    cerebritis    alzheimer's disease    endotheliitis    melanoma
    hepatitis    neuronitis    breast cancer


    P2RY6 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for P2RY6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 66 6 8700127 (1), 8913364 (1), 9730913 (1), 11711032 (1) (see all 6)
    glioma 24.7 4 8700127 (1), 8913364 (1), 11159687 (1), 9131407 (1)
    necrosis 0 1 12623123 (1)
    tumors 0 2 10068202 (1), 12623123 (1)

    Genetic Association Database (GAD): P2RY6
    Human Genome Epidemiology (HuGE) Navigator: P2RY6 (1 document)

    Export disorders for P2RY6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for P2RY6 gene, integrated from 10 sources (see all 129):
    (articles sorted by number of sources associating them with P2RY6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning, functional expression and tissue distribution of the human P2Y6 receptor. (PubMed id 8670200)1, 2, 3, 9 Communi D.... Boeynaems J.-M. (Biochem. Biophys. Res. Commun. 1996)
    2. Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. (PubMed id 9268704)1, 2, 9 Maier R.... Bilbe G. (Biochem. Biophys. Res. Commun. 1997)
    3. Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. (PubMed id 9412455)1, 2, 9 Maier R....Bilbe G. (Biochem. Biophys. Res. Commun. 1997)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family. (PubMed id 9286708)1, 2 Somers G.R....Venter D.J. (Genomics 1997)
    8. Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells. (PubMed id 12716436)1, 9 Lee H....Kim K.T. (J. Neurochem. 2003)
    9. P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. (PubMed id 19124756)1, 9 Jiang Y....Boyce J.A. (J. Immunol. 2009)
    10. Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP. (PubMed id 18250478)1, 9 Grbic D.M....Gendron F.P. (J. Immunol. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5031 HGNC: 8543 AceView: P2RY6 Ensembl:ENSG00000171631 euGenes: HUgn5031
    ECgene: P2RY6 Kegg: 5031 H-InvDB: P2RY6

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for P2RY6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for P2RY6 gene:
    Search GeneIP for patents involving P2RY6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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