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P2RY6 Gene

protein-coding GIFtS: 59

GC11P072653

pyrimidinergic receptor P2Y, G-protein coupled, 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC15335 ^²
P2Y6 ^¹, ², ³, ⁵

Descriptions
G-coupled nucleotide receptor ^²
P2 purinoceptor ^²
P2Y purinoceptor 6 ^²
P2Y6 receptor ^²
pyrimidinergic receptor P2Y, G-protein coupled, 6 ^²
pyrimidinergic receptor P2Y6 ^²

External Ids
HGNC: 8543¹
Entrez Gene: 5031²
UniProtKB: Q15077³
Ensembl: ENSG00000171631⁷

Search outside databases for aliases for P2RY6 gene

Previous GC identifers: GC11P075241 GC11P074515 GC11P073198 GC11P072701

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for P2RY6:

The product of this gene belongs to the family of G-protein coupled receptors. This family has

several receptor subtypes with different pharmacological selectivity, which overlaps in some

cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP,

partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding

the same isoform have been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: P2RY6_HUMAN, Q15077

Function: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by

G proteins which activate a phosphatidylinositol-calcium second messenger system

Gene Wiki entry for P2RY6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the P2RY6 gene

Entrez Gene cytogenetic band: 11q13.5 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.5

P2RY6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P072653: (about GC identifiers)

Start:	72,653,218 bp from pter
End:	72,687,312 bp from pter
Size:	34,095 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033927.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: P2RY6_HUMAN, Q15077 (See protein sequence)

Recommended Name: P2Y purinoceptor 6

Size: 328 amino acids; 36429 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

2B6R (3D)

Secondary accessions: Q15754

REFSEQ proteins (4 alternative transcripts):

NP_004145.1 NP_789766.1 NP_789767.1 NP_789768.1

ENSEMBL proteins:

ENSP00000377215 ENSP00000377216 ENSP00000377217 ENSP00000309771

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (P2Y6)
	Human Recombinant Proteins from Abnova (P2RY6)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	8670200

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Antibodies for P2RY6:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of P2RY6
	Sigma-Aldrich Antibodies for P2RY6
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (P2Y6), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for P2RY6

Assays for P2RY6:

	Invitrogen Assays for P2RY6
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q15077

ProtoNet protein and cluster: Q15077

2 Blocks protein families:

IPB001973 P2Y6 purinoceptor signature

IPB002286 P2 purinoceptor signature

UniProtKB/Swiss-Prot: P2RY6_HUMAN, Q15077

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RY6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RY6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_004154

Applied Biosystems Silencer® siRNAs for P2RY6

Sigma-Aldrich siRNA and siRNA Panels for P2RY6

Sigma-Aldrich shRNA Panels and shRNA for P2RY6

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for P2RY6
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_004154
Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_004154
untagged cDNA clones in CMV expression vector (see all 5): NM_004154

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004154

UniProtKB/Swiss-Prot: P2RY6_HUMAN, Q15077

Function: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by

G proteins which activate a phosphatidylinositol-calcium second messenger system

Genatlas biochemistry entry for P2RY6:

purinoceptor P2Y type 6,group 5,metabotropic,expressed in bone,placenta,osteoblastic and brain cell

lines,predominantly responding to ATP,G protein coupled receptor superfamily

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	TAS	8670200
GO:0045028	purinergic nucleotide receptor activity, G-protein coupled	IEA	--
GO:0045029	UDP-activated nucleotide receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for P2RY6 (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling

GeneDecks P2RY6 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for P2RY6

5/9 Interacting proteins for P2RY6 (ENSP00000309771³) via UniProtKB, MINT, and/or STRING (see all 9 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C14orf21	ENSP00000267425³	STRING (score=.923)
ACE	ENSP00000290866³	STRING (score=.839)
P2RX1	ENSP00000225538³	STRING (score=.81)
P2RX4	ENSP00000336607³	STRING (score=.81)
P2RX7	ENSP00000261826³	STRING (score=.809)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007200	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	TAS	8670200
GO:0030321	transepithelial chloride transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for P2RY6:

Antagonist Agonist

Compounds for P2RY6 available from Tocris Bioscience

Compound	Action	CAS number
UDP disodium salt	Endogenous ligand; competitive antagonist at P2Y14 receptors	[27821-45-0]
MRS 2578	Selective P2Y6 antagonist	[711019-86-2]
2-Methylthioadenosine triphosphate tetrasodium salt	P2 purinergic agonist	[43170-89-4]
PPADS tetrasodium salt	P2 purinergic antagonist	[149017-66-3]
PSB 0474	Potent and selective P2Y6 agonist	[917567-60-3]

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10/11 Novoseek chemical compound relationships for P2RY6 gene (see all 11 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
udpbetas	88.06	3	12737633 (2), 16543499 (1)
uridine diphosphate	83.68	14	16543499 (2), 9840612 (2), 16942026 (2), 12603858 (1) (see all 7)
atp	72.08	15	8700127 (2), 9704019 (1), 16475938 (1), 18635403 (1) (see all 10)
adp	71.26	6	8700127 (1), 9886992 (1), 12691958 (1), 9131407 (1) (see all 5)
uridine	64.15	7	8700127 (3), 11114308 (2), 18506388 (1)
ribose	55.97	1	16942026 (1)
udpglucose	54.16	1	16475938 (1)
calcium	45.73	9	15911103 (1), 9886992 (1), 9840612 (1), 11159687 (1) (see all 8)
purine	40.17	1	11401851 (1)
pyrimidine	31.73	2	12369950 (1), 16475938 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RY6)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RY6)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NM_004154

Sigma-Aldrich siRNA and siRNA Panels for P2RY6

Sigma-Aldrich shRNA Panels and shRNA for P2RY6

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004154 NM_176796 NM_176797 NM_176798

REFSEQ mRNAs for P2RY6 gene (4 alternative transcripts):

NM_004154.3 NM_176796.1 NM_176797.1 NM_176798.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004154 NM_176796 NM_176797 NM_176798

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NM_004154
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NM_004154
                                 untagged cDNA clones in CMV expression vector (see all 5): NM_004154

Additional cDNA sequence:

AF007891.1 AF007892.1 AF007893.1 AF218005.1 AF498920.1 AK311529.1 BC000571.2 BC009391.2

BT006771.1 CR597500.1 CR598708.1 CR598765.1 CR605588.1 CR606834.1 CR612681.1 CR614658.1

CR617080.1 CR618945.1 CR624871.1 CR626266.1 CR626706.1 CR626754.1 U52464.1 X97058.1

9 DOTS entries:

DT.440885 DT.95271557 DT.86852961 DT.100820471 DT.95271559 DT.100820481 DT.120679380 DT.100820482

DT.95271558

24/112 AceView cDNA sequences (see all 112 ):

NM_004154 X97058 CR612681 CR597500 BM918491 BU147495 CR605588 CR598708

BC009391 CR624871 BX397649 BX337204 NM_176797 CR617080 BX381745 BX396836

AF218005 CR606834 AX775903 CR626266 CR626706 BX337012 AF007891 BX280241

highest scoring ESTs for P2RY6:

AF007893 AA290864 AA464044 AA621733 AA778919 AF007891 AF007892 AF218005 AF498920 AI240463

Unigene Cluster for P2RY6:

Pyrimidinergic receptor P2Y, G-protein coupled, 6

Hs.16362 [show with all ESTs]

Unigene Representative Sequence: NM_004154

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for P2RY6 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	·	3d	^	4	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f	·	6g
SP1:							-		-		-		-				-
SP2:							-		-		-						-
SP3:									-		-						-
SP4:																	-
SP5:							-		-		-						-		-

About this scheme

ECgene alternative splicing isoforms for P2RY6

4 Ensembl transcripts including schematic representations:

ENST00000393590 ENST00000393591 ENST00000393592 ENST00000349767

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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P2RY6 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for P2RY6

¹ / ² / ³

4 probe-sets matching P2RY6 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38222_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.68	AF007893	1.00	1.00	1.00	1
68778_at²^{, 3}	U95-D	1	1.00	1.00	0.42	1.43	AI671378	0.80	1.00	0.91	1
208373_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004154	0.60	1.00	0.82	1
208373_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks P2RY6 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: GAGAGCTGGG

SOURCE GeneReport for Unigene cluster: Hs.16362
Expression variation in blood from EXPOLDB for P2RY6

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for P2RY6 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	P2RY6¹	--	pyrimidinergic receptor P2Y, G-protein coupled, 6	88.62(n) 94.15(a)	485202 XM_542320.1 XP_542320.1
chimpanzee (Pan troglodytes)	P2RY6¹	--	pyrimidinergic receptor P2Y, G-protein coupled, 6	99.09(n) 99.39(a)	451410 XM_508629.2 XP_508629.1
cow (Bos taurus)	P2RY6¹	--	pyrimidinergic receptor P2Y, G-protein coupled, 6	89.53(n) 92.68(a)	539703 XM_588870.3 XP_588870.1
rat (Rattus norvegicus)	P2ry6¹	--	pyrimidinergic receptor P2Y, G-protein coupled, 6	84.56(n) 88.04(a)	117264 NM_057124.2 NP_476465.1
mouse (Mus musculus)	P2ry6^{1, 5}	7⁵	pyrimidinergic receptor P2Y, G-protein coupled, 6^{1, 5}	84.15(n)¹ 87.12(a)¹	233571¹ NM_183168.1¹ NP_898991.1¹ AF298899⁵ AK008436⁵ (see all 10)

About this table Species with no ortholog for P2RY6

ENSEMBL Gene Tree for P2RY6

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for P2RY6 gene

P2RY4² P2RY1² P2RY2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/183 NCBI SNPs in P2RY6 are shown (see all 183 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 73)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7115806^1,2	A,C,F,H	72687080(+)	`TCAGCT/CACCCT`	1	--	ut3¹		4	EU EA WA	412
	rs3741152^1,2	A,C,F,H	72686562(-)	`CTCACC/TTCCCC`	4	--	ng3¹ ut3¹		6	EA EU WA	2066
	rs7103650^1,2	A,C,F,H	72659536(+)	`AGGTGG/CCTGGG`	4	--	int¹ ng5¹		5	EU EA WA	586
	rs12790863^1,2	A,C,F,H	72656879(+)	`CCCACA/GGGCAT`	3	--	ng5¹ int¹		4	EU EA WA	400
	rs12790447^1,2	A,C,F,H	72656686(+)	`CTAGAA/GCACTA`	3	--	int¹ ng5¹		12	EA NA EU WA	1054
	rs11235706^1,2	A,C,F,H	72657388(+)	`AGTGGG/ACCAAC`	3	--	int¹ ng5¹		8	EU EA WA	834
	rs7106903^1,2	A,C,F,H	72659758(+)	`agtgcG/Cttgaa`	4	--	int¹ ng5¹		5	EU EA WA	592
--	rs7125949^1,2	A,C,F,H	72686732(+)	`CATACG/AGGCTC`	4	--	ut3¹ ng3¹		4	EU EA WA	412
	rs11235707^1,2	A,C,F,H	72660641(+)	`GTTTCC/TTGCGG`	4	--	int¹ ng5¹		12	EU EA WA	1258
	rs11235702^1,2	A,C,F,H	72651242(+)	`gttcaT/Cgtctt`	2	--	ng5¹		8	EU EA WA	836

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HapMap Linkage Disequilibrium images for P2RY6 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 602451

4 Novoseek disease relationships for P2RY6 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
astrocytoma	66.97	6	8700127 (1), 8913364 (1), 9730913 (1), 11711032 (1) (see all 6)
glioma	19.68	4	8700127 (1), 8913364 (1), 11159687 (1), 9131407 (1)
necrosis	0.00	1	12623123 (1)
tumors	0.00	2	10068202 (1), 12623123 (1)

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/108 PubMed articles for P2RY6 gene (see all 108 ):

Cloning, functional expression and tissue distribution of the human P2Y6 receptor. (PubMed id 8670200)^{1, 2, 3, 4} Communi D.... Boeynaems J.-M. (1996)
Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. (PubMed id 9268704)^{1, 3, 4} Maier R.... Bilbe G. (1997)
Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. (PubMed id 9412455)^{1, 3, 4} Maier R....Bilbe G. (1997)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)^{3, 4} Wan D....Gu J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family. (PubMed id 9286708)^{3, 4} Somers G.R....Venter D.J. (1997)
Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells. (PubMed id 12716436)^{1, 3} Lee H....Kim K.T. (2003)
P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. (PubMed id 19124756)^{1, 3} Jiang Y....Boyce J.A. (2009)
Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP. (PubMed id 18250478)^{1, 3} Grbic D.M....Gendron F.P. (2008)
Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction. (PubMed id 16543499)^{1, 3} Wihlborg A.K....Erlinge D. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5031	HGNC: 8543	AceView: P2RY6	Ensembl:ENSG00000171631	euGenes: HUgn5031
ECgene: P2RY6	H-InvDB: P2RY6

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for P2RY6
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for P2RY6:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for P2RY6-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for P2RY6		Antibodies for P2RY6
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for P2RY6		Small molecules for P2RY6
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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P2RY6 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for P2RY6

Summaries
for P2RY6

Genomic Location
for P2RY6

Proteins
for P2RY6

Protein Domains/
Families
for P2RY6

Gene Function
for P2RY6

Pathways & Interactions
for P2RY6

Drugs & Compounds
for P2RY6

Transcripts
for P2RY6

Expression
for P2RY6

Orthologs
for P2RY6

Paralogs
for P2RY6

SNPs/Variants
for P2RY6

Disorders & Mutations
for P2RY6

Medical News
for P2RY6

Publications
for P2RY6

Search for P2RY6

Genome Databases showing P2RY6

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for P2RY6

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for P2RY6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

P2RY6 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor P2RY6

Summariesfor P2RY6

Genomic Locationfor P2RY6

Proteinsfor P2RY6

Protein Domains/Familiesfor P2RY6

Gene Functionfor P2RY6

Pathways & Interactionsfor P2RY6

Drugs & Compoundsfor P2RY6

Transcriptsfor P2RY6

Expression for P2RY6

Orthologsfor P2RY6

Paralogsfor P2RY6

SNPs/Variantsfor P2RY6

Disorders & Mutationsfor P2RY6

Medical Newsfor P2RY6

Publicationsfor P2RY6

Search for P2RY6

Genome Databases showing P2RY6

Other Databases showing P2RY6

Specialized Databases showing P2RY6

Licensable Technologiesfor P2RY6

Servicesfor P2RY6

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for P2RY6

Summaries
for P2RY6

Genomic Location
for P2RY6

Proteins
for P2RY6

Protein Domains/
Families
for P2RY6

Gene Function
for P2RY6

Pathways & Interactions
for P2RY6

Drugs & Compounds
for P2RY6

Transcripts
for P2RY6

Expression
for P2RY6

Orthologs
for P2RY6

Paralogs
for P2RY6

SNPs/Variants
for P2RY6

Disorders & Mutations
for P2RY6

Medical News
for P2RY6

Publications
for P2RY6

Licensable Technologies
for P2RY6

Services
for P2RY6