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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

P2RY6 Gene

protein-coding   GIFtS: 64
GCID: GC11P072975

Pyrimidinergic Receptor P2Y, G-Protein Coupled, 6

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Pyrimidinergic Receptor P2Y, G-Protein Coupled, 61 2
P2Y62 3 5
G-Coupled Nucleotide Receptor2
P2 Purinoceptor2
P2Y Purinoceptor 62
P2Y6 Receptor2

External Ids:    HGNC: 85431   Entrez Gene: 50312   Ensembl: ENSG000001716317   OMIM: 6024515   UniProtKB: Q150773   

Export aliases for P2RY6 gene to outside databases

Previous GC identifers: GC11P075241 GC11P074515 GC11P073198 GC11P072701 GC11P072653 GC11P069270


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for P2RY6 Gene:
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides
and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several
receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine
and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially
responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory
responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
(provided by RefSeq, Mar 2013)

GeneCards Summary for P2RY6 Gene: 
P2RY6 (pyrimidinergic receptor P2Y, G-protein coupled, 6) is a protein-coding gene. Diseases associated with P2RY6 include pancreatic diseases, and congestive heart failure, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Nucleotide-like (purinergic) receptors. GO annotations related to this gene include G-protein coupled receptor activity and UDP-activated nucleotide receptor activity. An important paralog of this gene is P2RY4.

UniProtKB/Swiss-Prot: P2RY6_HUMAN, Q15077
Function: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins
which activate a phosphatidylinositol-calcium second messenger system

summary for P2RY6 Gene:
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine
nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13
and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10
receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4
receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13
and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades
including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They
have diverse physiological roles including regulation of platelet aggregation, muscle contraction,
neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the P2RY6 gene promoter:
         Egr-2   Spz1   Hand1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidP2RY6 promoter sequence
   Search SABiosciences Chromatin IP Primers for P2RY6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat P2RY6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.5

P2RY6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P2RY6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P072975:  view genomic region     (about GC identifiers)

Start:
72,975,550 bp from pter      End:
73,009,664 bp from pter
Size:
34,115 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: P2RY6_HUMAN, Q15077 (See protein sequence)
Recommended Name: P2Y purinoceptor 6  
Size: 328 amino acids; 36429 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from and Proteopedia for P2RY6:
2B6R (3D)    
Secondary accessions: Q15754

Explore the universe of human proteins at neXtProt for P2RY6: NX_Q15077

Explore proteomics data for P2RY6 at MOPED 

P2RY6 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

P2RY6 Protein Expression

REFSEQ proteins (8 alternative transcripts): 
NP_001264133.1  NP_001264134.1  NP_001264135.1  NP_001264136.1  NP_001264137.1  NP_789766.1  NP_789767.1  NP_789768.1  

ENSEMBL proteins: 
 ENSP00000443427   ENSP00000445652   ENSP00000309771   ENSP00000377217   ENSP00000441079  
 ENSP00000377216   ENSP00000442551   ENSP00000377215   ENSP00000442509   ENSP00000440770  
 ENSP00000442990  
Reactome Protein details: Q15077
Human Recombinant Protein Products for P2RY6: 
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Novus Biologicals P2RY6 Proteins
Novus Biologicals P2RY6 Lysates
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Cloud-Clone Corp. Proteins for P2RY6 

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005886plasma membrane TAS--
GO:0005887integral to plasma membrane TAS8670200
GO:0016021integral to membrane ----
GO:0016323basolateral plasma membrane IEA--
GO:0016324apical plasma membrane IEA--

P2RY6 for ontologies           About GeneDecksing



P2RY6 Antibody Products: 
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Abcam antibodies for P2RY6
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ThermoFisher Antibodies for P2RY6
LSBio Antibodies in human, mouse, rat for P2RY6 

Assay Products for P2RY6: 
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GenScript Custom Assay Services for P2RY6
Browse Enzo Life Sciences for kits & assays
Cloud-Clone Corp. ELISAs for P2RY6 
Cloud-Clone Corp. CLIAs for P2RY6


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
P2R: Purinergic receptors
P2RY: GPCR / Class A : Purinergic receptors, P2Y

IUPHAR Guide to PHARMACOLOGY protein family classification: P2Y6 receptor 
P2Y receptors

4 InterPro protein domains:
 IPR001973 P2Y6_purnocptor
 IPR017452 GPCR_Rhodpsn_7TM
 IPR002286 purinergic_P2Y_rcpt
 IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q15077

ProtoNet protein and cluster: Q15077

2 Blocks protein domains:
IPB001973 P2Y6 purinoceptor signature
IPB002286 P2 purinoceptor signature


UniProtKB/Swiss-Prot: P2RY6_HUMAN, Q15077
Similarity: Belongs to the G-protein coupled receptor 1 family


P2RY6 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: P2RY6_HUMAN, Q15077
Function: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins
which activate a phosphatidylinositol-calcium second messenger system

     Genatlas biochemistry entry for P2RY6:
purinoceptor P2Y type 6,group 5,metabotropic,expressed in bone,placenta,osteoblastic and brain cell
lines,predominantly responding to ATP,G protein coupled receptor superfamily

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004930G-protein coupled receptor activity TAS8670200
GO:0045028G-protein coupled purinergic nucleotide receptor activity IEA--
GO:0045029UDP-activated nucleotide receptor activity IEA--
     
P2RY6 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for P2RY6:
 Increased gamma-H2AX phosphory 

     7 MGI mutant phenotypes (inferred from 3 alleles(MGI details for P2ry6):
 cardiovascular system  cellular  hematopoietic system  immune system  muscle 
 no phenotypic analysis  respiratory system 

P2RY6 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out P2ry6tm1.1Brob for P2RY6

   inGenious Targeting Laboratory - Custom generated mouse model solutions for P2RY6 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for P2RY6

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for P2RY6 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for P2RY6 

miRNA
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat P2RY6
1 QIAGEN miScript miRNA Assays for microRNA that regulate P2RY6:
hsa-miR-377
SwitchGear 3'UTR luciferase reporter plasmidP2RY6 3' UTR sequence
Inhib. RNA
Products:
    
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Gene Editing
Products:
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Sirion Biotech Customized adenovirus for overexpression of P2RY6

Clone
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OriGene clones in human, mouse for P2RY6 (see all 26)
OriGene ORF clones in mouse, rat for P2RY6
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 4): P2RY6 (NM_176798)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for P2RY6
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat P2RY6
Sirion Biotech Customized lentivirus for stable overexpression of P2RY6 
                     Customized lentivirus expression plasmids for stable overexpression of P2RY6 

Cell Line
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Search LifeMap BioReagents cell lines for P2RY6
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY6


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for P2RY6 About   (see all 6)                                                                                              See pathways by source

SuperPathContained pathways About
1Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
GPCRs, Class A Rhodopsin-like0.41
GPCR ligand binding0.71
Neuroactive ligand-receptor interaction0.37
2Nucleotide-like (purinergic) receptors
Nucleotide-like (purinergic) receptors0.75
Nucleotide GPCRs0.59
P2Y receptors0.75
3Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
4G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90
5Signal transduction IP3 signaling
Signal transduction IP3 signaling0.92

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for P2RY6
    Signal transduction IP3 signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for P2RY6
    P2Y Receptor Signaling

1 GeneGo (Thomson Reuters) Pathway for P2RY6
    Signal transduction IP3 signaling

2 BioSystems Pathways for P2RY6
    GPCRs, Class A Rhodopsin-like
Nucleotide GPCRs

5/9        Reactome Pathways for P2RY6 (see all 9)
    GPCR downstream signaling
P2Y receptors
Gastrin-CREB signalling pathway via PKC and MAPK
Signaling by GPCR
GPCR ligand binding


1         Kegg Pathway  (Kegg details for P2RY6):
    Neuroactive ligand-receptor interaction


P2RY6 for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for P2RY6

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/124 Interacting proteins for P2RY6 (Q150773 ENSP000003097714) via UniProtKB, MINT, STRING, and/or I2D (see all 124)
InteractantInteraction Details
GeneCardExternal ID(s)
KRTAP4-12Q9BQ663I2D: score=1 
ADRBK1ENSP000003122624STRING: ENSP00000312262
AGTR1ENSP000002734304STRING: ENSP00000273430
BDKRB2ENSP000003077134STRING: ENSP00000307713
CASRENSP000002961544STRING: ENSP00000296154
About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007186G-protein coupled receptor signaling pathway ----
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway TAS8670200
GO:0014911positive regulation of smooth muscle cell migration IEA--
GO:0030321transepithelial chloride transport IEA--

P2RY6 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

P2RY6 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for P2RY6 available from Tocris Bioscience    About this table
CompoundAction CAS #
MRS 2365Highly potent and selective P2Y1 agonist[436847-09-5]
alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist[7292-42-4]
UTPgammaS trisodium saltSelective P2Y2/4 agonist[1266569-94-1]
MRS 2500 tetraammonium saltExtremely potent and selective P2Y1 antagonist[630103-23-0]
MRS 2179 tetrasodium saltSelective P2Y1 antagonist[101204-49-3]

1 HMDB Compound for P2RY6    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

10/16 IUPHAR Ligands for P2RY6 (P2Y6 receptor) (see all 16)    About this table 
LigandTypeActionAffinityPubmed IDs
compound 18a [PMID:22901672]
AgonistAgonist8.122901672
MRS2957
AgonistAgonist7.920446735
5-iodoUDP
AgonistFull agonist7.8216942026
UDP-β-S
AgonistFull agonist7.5516475938
MRS2578
AntagonistAntagonist7.415081875
3-phenacyl-UDP
AgonistFull agonist7.217125260
MRS2567
AntagonistAntagonist6.915081875
INS48823
AgonistFull agonist6.916475938
Up3U
AgonistFull agonist6.716475938
UDP
AgonistFull agonist6.58670200

10/19 Novoseek inferred chemical compound relationships for P2RY6 gene (see all 19)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
udpbetas 87.8 3 12737633 (2), 16543499 (1)
uridine diphosphate 84.1 14 16543499 (2), 9840612 (2), 16942026 (2), 12603858 (1) (see all 7)
bzatp 80 1 16373435 (1)
alpha,beta methylene atp 74.7 1 12691958 (1)
adpbetas 72.5 1 19836435 (1)
adp 72.4 7 8700127 (1), 9886992 (1), 12691958 (1), 19836435 (1) (see all 6)
atp 71.9 15 8700127 (2), 9704019 (1), 16475938 (1), 18635403 (1) (see all 10)
ppads 71.1 2 17702822 (1)
uridine 63.2 7 8700127 (3), 11114308 (2), 18506388 (1)
udpglucose 58.4 1 16475938 (1)

Search CenterWatch for drugs/clinical trials and news about P2RY6

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for P2RY6 gene (9 alternative transcripts): 
NM_001277204.1  NM_001277205.1  NM_001277206.1  NM_001277207.1  NM_001277208.1  NM_176796.2  NM_176797.2  NM_176798.2  
NM_004154.3  

Unigene Cluster for P2RY6:

Pyrimidinergic receptor P2Y, G-protein coupled, 6
Hs.16362  [show with all ESTs]
Unigene Representative Sequence: NM_004154
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000540342 ENST00000542092 ENST00000349767 ENST00000393592 ENST00000544437
ENST00000393591 ENST00000540124 ENST00000393590(uc001otm.3 uc001otn.3 uc001otq.3 uc001otr.3 uc001ots.3)
ENST00000536225 ENST00000535931 ENST00000538328

miRNA
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1 QIAGEN miScript miRNA Assays for microRNA that regulate P2RY6:
hsa-miR-377
SwitchGear 3'UTR luciferase reporter plasmidP2RY6 3' UTR sequence
Inhib. RNA
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GenScript: all cDNA clones in your preferred vector (see all 4): P2RY6 (NM_176798)
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat P2RY6
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                     Customized lentivirus expression plasmids for stable overexpression of P2RY6 
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat P2RY6

Additional mRNA sequence: 

AF007891.1 AF007892.1 AF007893.1 AF218005.1 AF498920.1 AK311529.1 BC000571.2 BC009391.2 
BT006771.1 U52464.1 X97058.1 

9 DOTS entries:

DT.440885  DT.95271557  DT.95271559  DT.100820481  DT.86852961  DT.100820471  DT.100820482  DT.120679380 
DT.95271558 

24/112 AceView cDNA sequences (see all 112):

CR614658 AF498920 CR612681 CR597500 CR598765 BX337012 BF769476 AF218005 
BM918491 BX381745 CB242913 NM_176797 BX397649 CR617080 BX280241 BX337204 
AF007893 CR624871 X97058 CR626266 AF007891 CR626754 NM_004154 CR598708 

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for P2RY6 (see all 8)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1:                    -     -     -     -           -                                                   
SP2:                    -     -     -                 -                                                   
SP3:                          -     -                 -                                                   
SP4:                                                  -                                                   
SP5:                    -     -     -                 -     -                                             


ECgene alternative splicing isoforms for P2RY6

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

P2RY6 expression in normal human tissues (normalized intensities)      P2RY6 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GAGAGCTGGG
P2RY6 Expression
About this image


P2RY6 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/4 selected tissues (see all 4) fully expand
 
 Blood (Hematopoietic System)    fully expand to see all 2 entries
         Monocytes Peripheral Blood
 
 Neuron (Nervous System)
         nerve   
 
 Lateral Plate Mesoderm (Gastrulation Derivatives)
         Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
 
 Placenta (Extraembryonic Tissues)

See P2RY6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for P2RY6

SOURCE GeneReport for Unigene cluster: Hs.16362
    SABiosciences Expression via Pathway-Focused PCR Array including P2RY6: 
          G Protein Coupled Receptors 384HT in human mouse rat

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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for P2RY6 gene from 4/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia P2ry61 , 5 pyrimidinergic receptor P2Y, G-protein coupled, 61, 5 84.15(n)1
87.12(a)1
  7 (54.46 cM)5
2335711  NM_183168.21  NP_898991.11 
 1009376345 
chicken
(Gallus gallus)
Aves P2RY61 pyrimidinergic receptor P2Y, G-protein coupled, 6 70.33(n)
64.08(a)
  396114  NM_205195.1  NP_990526.1 
lizard
(Anolis carolinensis)
Reptilia P2RY66
--
(see all 4)
Uncharacterized protein
(see all 4)
60(a)
29(a)
(see all 4)
1 ↔ 1
possible ortholog
(see all 4)
GL343298.1(283065-284039)
GL343625.1(140329-141560)
zebrafish
(Danio rerio)
Actinopterygii LOC5660991 p2Y purinoceptor 3-like 61.4(n)
62.83(a)
  566099  XM_689367.4  XP_694459.1 


ENSEMBL Gene Tree for P2RY6 (if available)
TreeFam Gene Tree for P2RY6 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for P2RY6 gene
P2RY42  CYSLTR12  LPAR42  CYSLTR22  P2RY22  PTAFR2  OXGR12  P2RY112  
P2RY12  GPR172  GPR1742  LPAR62  LPAR52  GPR1832  P2RY102  SUCNR12  
18/24 SIMAP similar genes for P2RY6 using alignment to 4 protein entries:     P2RY6_HUMAN (see all proteins) (see all similar genes):
GPR18    P2RY4    F2RL1    FPR2    CCR5    P2RY2
CXCR2    CCR2    CCR7    GPR1    GPR17    LTB4R
F2RL3    GPR183    LPAR4    P2RY1    CX3CR1    CYSLTR2

P2RY6 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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10/749 SNPs in P2RY6 are shown (see all 749)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs112357021,2
C,F,A,H--72973594(+) gttcaT/Cgtctt 3 -- us2k118Minor allele frequency- C:0.14NS EA NA WA CSA 1744
rs1434978271,2
--72973615(+) TTCTGC/TTAGGT 4 -- us2k10--------
rs1846638171,2
--72973709(+) CCAGTC/TGGTAG 4 -- us2k10--------
rs1509321751,2
--72973801(+) TTTACA/GATTTT 4 -- us2k10--------
rs1891381241,2
--72973836(+) AAAAAG/TTGTTC 4 -- us2k10--------
rs1419215271,2
--72973918(+) CCCAGA/GGAGAA 4 -- us2k10--------
rs1166387691,2
F--72973992(+) AGGGAA/GGAGTG 4 -- us2k11Minor allele frequency- G:0.02WA 118
rs1469088481,2
--72974010(+) GAGGAA/GGAACA 4 -- us2k10--------
rs1815712661,2
--72974163(+) ATAGGA/TGGGCA 4 -- us2k10--------
rs1393207761,2
--72974272(+) GCCTAA/GGATTC 4 -- us2k10--------

HapMap Linkage Disequilibrium report for P2RY6 (72975550 - 73009664 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for P2RY6:    About this table     
Variant IDTypeSubtypePubMed ID
nsv387CNV Insertion18451855
nsv520665CNV Loss19592680
nsv832208CNV Gain17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602451    OMIM disorders: --

14 diseases for P2RY6:    About MalaCards
pancreatic diseases    congestive heart failure    insulinoma    inflammatory bowel disease
myocardial infarction    neuroblastoma    cerebritis    retinitis
pancreatitis    alzheimer's disease    endotheliitis    melanoma
hepatitis    neuronitis


P2RY6 for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

4 Novoseek inferred disease relationships for P2RY6 gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
astrocytoma 66 6 8700127 (1), 8913364 (1), 9730913 (1), 11711032 (1) (see all 6)
glioma 24.7 4 8700127 (1), 8913364 (1), 11159687 (1), 9131407 (1)
necrosis 0 1 12623123 (1)
tumors 0 2 10068202 (1), 12623123 (1)

Genetic Association Database (GAD): P2RY6
Human Genome Epidemiology (HuGE) Navigator: P2RY6 (1 document)

Export disorders for P2RY6 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for P2RY6 gene, integrated from 9 sources (see all 129):
(articles sorted by number of sources associating them with P2RY6)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Cloning, functional expression and tissue distribution of the human P2Y6 receptor. (PubMed id 8670200)1, 2, 3, 9 Communi D.... Boeynaems J.-M. (1996)
  2. Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. (PubMed id 9268704)1, 2, 9 Maier R.... Bilbe G. (1997)
  3. Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. (PubMed id 9412455)1, 2, 9 Maier R....Bilbe G. (1997)
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  7. Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family. (PubMed id 9286708)1, 2 Somers G.R....Venter D.J. (1997)
  8. Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells. (PubMed id 12716436)1, 9 Lee H....Kim K.T. (2003)
  9. P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. (PubMed id 19124756)1, 9 Jiang Y....Boyce J.A. (2009)
  10. Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP. (PubMed id 18250478)1, 9 Grbic D.M....Gendron F.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5031 HGNC: 8543 AceView: P2RY6 Ensembl:ENSG00000171631 euGenes: HUgn5031
ECgene: P2RY6 Kegg: 5031 H-InvDB: P2RY6

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for P2RY6 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for P2RY6 gene:
Search GeneIP for patents involving P2RY6

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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