P2RY6 Gene
protein-coding GIFtS: 63
GCID: GC11P072975
|
|
pyrimidinergic receptor P2Y, G-protein coupled, 6
| |
Aliases
for P2RY6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Pyrimidinergic Receptor P2Y, G-Protein Coupled, 61 2 | | P2Y61 2 3 5 | | G-Coupled Nucleotide Receptor2 | | P2 Purinoceptor2 | | P2Y Purinoceptor 62 | | P2Y6 Receptor2 |
Export aliases for P2RY6 gene to outside databasesPrevious GC identifers: GC11P075241 GC11P074515 GC11P073198 GC11P072701 GC11P072653 GC11P069270 |
Summaries
for P2RY6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for P2RY6:
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptorsubtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridinenucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Fourtranscript variants encoding the same isoform have been identified for this gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: P2RY6_HUMAN, Q15077Function: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins whichactivate a phosphatidylinositol-calcium second messenger system
 summary
for P2RY6: P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine
nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13
and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10
receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4
receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13
and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades
including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They
have diverse physiological roles including regulation of platelet aggregation, muscle contraction,
neurotransmission, and epithelial cell communication and migration.
Gene Wiki entry for P2RY6
|
Genomic Views
for P2RY6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the P2RY6 gene promoter:
Egr-2 Spz1 Hand1 E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for P2RY6
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat P2RY6 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.5 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.5P2RY6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P072975: view genomic region
(about GC identifiers)
Start:
|
72,975,550 bp from pter |
End:
|
73,009,664 bp from pter |
Size:
|
34,115 bases |
Orientation:
|
plus strand |
|
Proteins
for P2RY6 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: P2RY6_HUMAN, Q15077 (See
protein sequence)Recommended Name: P2Y purinoceptor 6 Size: 328 amino acids; 36429 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
1 PDB 3D structure from  and Proteopedia  for P2RY6:2B6R (3D)
Secondary accessions: Q15754Explore the universe of human proteins at neXtProt for P2RY6: NX_Q15077
P2RY6 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_004145.1 NP_789766.1 NP_789767.1 NP_789768.1
ENSEMBL proteins: ENSP00000443427 ENSP00000445652 ENSP00000309771 ENSP00000377217 ENSP00000441079 ENSP00000377216 ENSP00000442551 ENSP00000377215 ENSP00000442509 ENSP00000440770 ENSP00000442990 Reactome Protein details: Q15077
Human Recombinant Protein Products for P2RY6:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
P2RY6 for ontologies About GeneDecksing
P2RY6 Antibody Products:
Assay Products for P2RY6: |
Protein
Domains /
Families
for P2RY6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
P2RY6 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q15077ProtoNet protein and cluster: Q15077 2 Blocks protein families: IPB001973 P2Y6 purinoceptor signature IPB002286 P2 purinoceptor signature
UniProtKB/Swiss-Prot: P2RY6_HUMAN, Q15077Similarity: Belongs to the G-protein coupled receptor 1 family |
Function
for P2RY6 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: P2RY6_HUMAN, Q15077Function: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins whichactivate a phosphatidylinositol-calcium second messenger system Genatlas biochemistry entry for P2RY6:purinoceptor P2Y type 6,group 5,metabotropic,expressed in bone,placenta,osteoblastic and brain cell lines,predominantlyresponding to ATP,G protein coupled receptor superfamily
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004930 | G-protein coupled receptor activity |
TAS | 8670200 | | GO:0045028 | G-protein coupled purinergic nucleotide receptor activity |
IEA | -- | | GO:0045029 | UDP-activated nucleotide receptor activity |
IEA | -- |
P2RY6 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for P2RY6:
7 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for P2ry6):
P2RY6 for phenotypes About GeneDecksing
Animal Models:
Mouse knock-out P2ry6tm1.1Brob for P2RY6
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for P2RY6 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for P2RY6 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): P2RY6 (NM_176798) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for P2RY6 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat P2RY6 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY6 |
|
Pathways & Interactions
for P2RY6 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Class A/1 (Rhodopsin-like receptors) | | | 2 | Nucleotide-like (purinergic) receptors | | | 3 | Signaling by GPCR | | | 4 | Signal transduction_IP3 signaling | | | 5 | G alpha (q) signalling events | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1 EMD Millipore Pathway for P2RY6
1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for P2RY6
1  GeneGo (Thomson Reuters) Pathway for P2RY6
2  BioSystems Pathways for P2RY6
5/9 
Reactome Pathways for P2RY6 (see all 9)
1 
Kegg Pathway (Kegg details for P2RY6):
P2RY6 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for P2RY6
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/124 Interacting proteins for P2RY6 (Q150773 ENSP000003097714) via UniProtKB, MINT, STRING, and/or I2D (see all 124)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007200 | phospholipase C-activating G-protein coupled receptor signaling pathway |
TAS | 8670200 | | GO:0014911 | positive regulation of smooth muscle cell migration |
IEA | -- | | GO:0030321 | transepithelial chloride transport |
IEA | -- |
P2RY6 for ontologies About GeneDecksing
|
Drugs & Compounds
for P2RY6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
P2RY6 for compounds About GeneDecksing
Compounds for P2RY6 available from Tocris Bioscience About this table
1 HMDB Compound for P2RY6 About this table
10/19 Novoseek chemical compound relationships for P2RY6 gene (see all 19) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| udpbetas |
87.8 |
3 |
12737633 (2), 16543499 (1) |
| uridine diphosphate |
84.1 |
14 |
16543499 (2), 9840612 (2), 16942026 (2), 12603858 (1) (see all 7) |
| bzatp |
80 |
1 |
16373435 (1) |
| alpha,beta methylene atp |
74.7 |
1 |
12691958 (1) |
| adpbetas |
72.5 |
1 |
19836435 (1) |
| adp |
72.4 |
7 |
8700127 (1), 9886992 (1), 12691958 (1), 19836435 (1) (see all 6) |
| atp |
71.9 |
15 |
8700127 (2), 9704019 (1), 16475938 (1), 18635403 (1) (see all 10) |
| ppads |
71.1 |
2 |
17702822 (1) |
| uridine |
63.2 |
7 |
8700127 (3), 11114308 (2), 18506388 (1) |
| udpglucose |
58.4 |
1 |
16475938 (1) |
Search CenterWatch for drugs/clinical trials and news about P2RY6
|
Transcripts
for P2RY6 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for P2RY6 gene (4 alternative transcripts): NM_004154.3 NM_176796.1 NM_176797.1 NM_176798.1 Unigene Cluster for P2RY6: Pyrimidinergic receptor P2Y, G-protein coupled, 6 Hs.16362 [show with all ESTs]Unigene Representative Sequence: NM_00415411 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000540342 ENST00000542092 ENST00000349767 ENST00000393592 ENST00000544437
ENST00000393591 ENST00000540124 ENST00000393590(uc001otm.3 uc001otn.3 uc001otq.3 uc001otr.3 uc001ots.3)
ENST00000536225 ENST00000535931 ENST00000538328
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for P2RY6 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for P2RY6 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): P2RY6 (NM_176798) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for P2RY6 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat P2RY6 |
Additional cDNA sequence: AF007891.1 AF007892.1 AF007893.1 AF218005.1 AF498920.1 AK311529.1 BC000571.2 BC009391.2 BT006771.1 U52464.1 X97058.1 9 DOTS entries: DT.440885 DT.95271557 DT.95271559 DT.100820481 DT.86852961 DT.100820471 DT.100820482 DT.120679380 DT.95271558 24/112 AceView cDNA sequences (see all 112): CR626754 CR624871 CR614658 CR606834 CR605588 BU147495 BX396836 X97058 CB242913 BX280241 BM918491 AL525099 BX397649 BC009391 AF498920 CR598708 CR626706 BX381745 CR598765 BX337204 BX337012 BC000571 NM_004154 AI473230
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for P2RY6 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d | · | 6e | · | 6f | · | 6g |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | | | | | - | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for P2RY6
|
Expression
for P2RY6 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| P2RY6 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGAGCTGGG
About this image
See P2RY6 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for P2RY6
SOURCE GeneReport for Unigene cluster: Hs.16362
SABiosciences Expression via Pathway-Focused PCR Array including P2RY6:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for P2RY6
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat P2RY6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat P2RY6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat P2RY6 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY6 |
Orthologs
for P2RY6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for P2RY6 gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
P2RY61 |
pyrimidinergic receptor P2Y, G-protein coupled, 6 |
70.33(n)
64.08(a) |
|
396114 NM_205195.1 NP_990526.1 |
lizard
(Anolis carolinensis) |
Reptilia |
P2RY66 |
-- |
60(a) |
1 ↔ 1 |
GL343298.1(283065-284039) |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5660991 |
p2Y purinoceptor 3-like |
61.4(n)
62.83(a) |
|
566099 XM_689367.4 XP_694459.1 |
ENSEMBL Gene Tree for P2RY6 (if available)
TreeFam Gene Tree for P2RY6 (if available) |
Paralogs
for P2RY6 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for P2RY6 gene
- P2RY42 CYSLTR12 LPAR42 CYSLTR22 P2RY22 PTAFR2 OXGR12 P2RY112
- GPR172 P2RY12 GPR1742 LPAR62 LPAR52 GPR1832 SUCNR12 P2RY102
18/24 SIMAP similar genes for P2RY6 using alignment to 4 protein entries: P2RY6_HUMAN (see all proteins)
(see all similar genes):GPR18 P2RY4 F2RL1 CCR5 P2RY2 CXCR2
CCR2 CCR7 GPR1 GPR17 LTB4R F2RL3
GPR183 LPAR4 P2RY1 CX3CR1 CYSLTR2 KPG_011
P2RY6 for paralogs About GeneDecksing
|
Genomic Variants
for P2RY6 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for P2RY6 (72975550 - 73009664 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for P2RY6: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing P2RY6 |
|
Disorders
/ Diseases
for P2RY6 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
P2RY6 for disorders About GeneDecksing
OMIM gene information: 602451
OMIM disorders: --
16  diseases for P2RY6: About MalaCardscongestive heart failure inflammatory bowel disease myocardial infarction insulinoma
astrocytoma alzheimer's disease pancreatic diseases pancreatitis
fibrosis cerebritis neuroblastoma retinitis
melanoma hepatitis neuronitis carcinoma
4 Novoseek disease relationships for P2RY6 gene About this table
Human Genome Epidemiology (HuGE) Navigator: P2RY6 (1 document)
Export disorders for P2RY6 gene to outside databases
|
Publications
for P2RY6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for P2RY6 gene, integrated from 9 sources (see all 127):
(articles sorted by number of sources associating them with P2RY6) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning, functional expression and tissue distribution of the human P2Y6 receptor. (PubMed id 8670200)1, 2, 3, 9 Communi D.... Boeynaems J.-M. (1996)
- Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. (PubMed id 9268704)1, 2, 9 Maier R.... Bilbe G. (1997)
- Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. (PubMed id 9412455)1, 2, 9 Maier R....Bilbe G. (1997)
- Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family. (PubMed id 9286708)1, 2 Somers G.R....Venter D.J. (1997)
- Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells. (PubMed id 12716436)1, 9 Lee H....Kim K.T. (2003)
- P2Y6 receptors require an intact cysteinyl leukotriene synthetic and signaling system to induce survival and activation of mast cells. (PubMed id 19124756)1, 9 Jiang Y....Boyce J.A. (2009)
- Intestinal inflammation increases the expression of the P2Y6 receptor on epithelial cells and the release of CXC chemokine ligand 8 by UDP. (PubMed id 18250478)1, 9 Grbic D.M....Gendron F.P. (2008)
- Positive inotropic effects by uridine triphosphate (UTP) and uridine diphosphate (UDP) via P2Y2 and P2Y6 receptors on cardiomyocytes and release of UTP in man during myocardial infarction. (PubMed id 16543499)1, 9 Wihlborg A.K....Erlinge D. (2006)
|
External Searches for P2RY6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing P2RY6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing P2RY6 gene
(According to HUGE)
About This Section
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Specialized Databases showing P2RY6 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for P2RY6 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for P2RY6 gene:
Search GeneIP for patents involving P2RY6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for P2RY6 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
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| | |  | OriGene Antibodies for P2RY6 | | OriGene shRNA RFP for P2RY6 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for P2RY6 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for P2RY6 | | | OriGene Protein Over-expression Lysate for P2RY6 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for P2RY6 | | OriGene 3'-UTR Clone for P2RY6 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for P2RY6 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for P2RY6 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for P2RY6 | | OriGene Custom Protein Services for P2RY6 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat P2RY6 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing P2RY6 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat P2RY6 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat P2RY6 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat P2RY6 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat P2RY6 |
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| | | | Tocris compounds for P2RY6 |
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 | | | P2RY6 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY6 |
|  |  |  |  | | | | ThermoFisher Antibodies for P2RY6 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat P2RY6 |
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