Free for academic non-profit institutions. Other users need a Commercial license

Aliases for P2RY6 Gene

Aliases for P2RY6 Gene

  • Pyrimidinergic Receptor P2Y, G-Protein Coupled, 6 2 3
  • P2Y6 3 4 6
  • G-Coupled Nucleotide Receptor 3
  • P2Y Purinoceptor 6 3
  • P2 Purinoceptor 3
  • P2Y6 Receptor 3

External Ids for P2RY6 Gene

Previous GeneCards Identifiers for P2RY6 Gene

  • GC11P075241
  • GC11P074515
  • GC11P073198
  • GC11P072701
  • GC11P072653
  • GC11P072975
  • GC11P069270

Summaries for P2RY6 Gene

Entrez Gene Summary for P2RY6 Gene

  • The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

GeneCards Summary for P2RY6 Gene

P2RY6 (Pyrimidinergic Receptor P2Y, G-Protein Coupled, 6) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and UDP-activated nucleotide receptor activity. An important paralog of this gene is PTAFR.

UniProtKB/Swiss-Prot for P2RY6 Gene

  • Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system

Tocris Summary for P2RY6 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10 receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4 receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13 and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They have diverse physiological roles including regulation of platelet aggregation, muscle contraction, neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY6 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY6 Gene

Genomics for P2RY6 Gene

Regulatory Elements for P2RY6 Gene

Genomic Location for P2RY6 Gene

Start:
73,264,505 bp from pter
End:
73,298,625 bp from pter
Size:
34,121 bases
Orientation:
Plus strand

Genomic View for P2RY6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for P2RY6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY6 Gene

Proteins for P2RY6 Gene

  • Protein details for P2RY6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15077-P2RY6_HUMAN
    Recommended name:
    P2Y purinoceptor 6
    Protein Accession:
    Q15077
    Secondary Accessions:
    • Q15754

    Protein attributes for P2RY6 Gene

    Size:
    328 amino acids
    Molecular mass:
    36429 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY6 Gene

neXtProt entry for P2RY6 Gene

Proteomics data for P2RY6 Gene at MOPED

Post-translational modifications for P2RY6 Gene

  • Glycosylation at Asn5
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for P2RY6 Gene

Domains for P2RY6 Gene

Gene Families for P2RY6 Gene

HGNC:
  • P2RY :GPCR / Class A : Purinergic receptors, P2Y
  • P2R :Purinergic receptors
IUPHAR :

Protein Domains for P2RY6 Gene

Suggested Antigen Peptide Sequences for P2RY6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15077

UniProtKB/Swiss-Prot:

P2RY6_HUMAN :
  • Q15077
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY6: view

Function for P2RY6 Gene

Molecular function for P2RY6 Gene

GENATLAS Biochemistry: purinoceptor P2Y type 6,group 5,metabotropic,expressed in bone,placenta,osteoblastic and brain cell lines,predominantly responding to ATP,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for extracellular UDP > UTP > ATP. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system

Gene Ontology (GO) - Molecular Function for P2RY6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity TAS 8670200
GO:0005515 protein binding IPI 25416956
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
GO:0045029 UDP-activated nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY6: view
genes like me logo Genes that share phenotypes with P2RY6: view

Animal Models for P2RY6 Gene

MGI Knock Outs for P2RY6:

Animal Model Products

CRISPR Products

miRNA for P2RY6 Gene

miRTarBase miRNAs that target P2RY6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for P2RY6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for P2RY6 Gene

Localization for P2RY6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY6 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY6 Gene COMPARTMENTS Subcellular localization image for P2RY6 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for P2RY6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8670200
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with P2RY6: view

Pathways for P2RY6 Gene

genes like me logo Genes that share pathways with P2RY6: view

Pathways by source for P2RY6 Gene

1 KEGG pathway for P2RY6 Gene
1 GeneGo (Thomson Reuters) pathway for P2RY6 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for P2RY6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 8670200
GO:0014911 positive regulation of smooth muscle cell migration IEA --
GO:0030321 transepithelial chloride transport IEA --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with P2RY6: view

Compounds for P2RY6 Gene

(5) Tocris Compounds for P2RY6 Gene

Compound Action Cas Number
alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist [1343364-54-4]
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 [475193-31-8]
MRS 2179 tetrasodium salt Selective P2Y1 antagonist [1454889-37-2]
MRS 2365 Highly potent and selective P2Y1 agonist [436847-09-5]
MRS 2500 tetraammonium salt Extremely potent and selective P2Y1 antagonist [630103-23-0]

(1) HMDB Compounds for P2RY6 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(16) IUPHAR Ligand for P2RY6 Gene

Ligand Type Action Affinity Pubmed IDs
compound 18a [PMID:22901672] Agonist Agonist 8.1
MRS2957 Agonist Agonist 7.9
5-iodoUDP Agonist Full agonist 7.82
UDP-beta-S Agonist Full agonist 7.55
MRS2578 Antagonist Antagonist 7.4
3-phenacyl-UDP Agonist Full agonist 7.2
UDP Agonist Full agonist 7.13
MRS2567 Antagonist Antagonist 6.9
INS48823 Agonist Full agonist 6.9
Up3U Agonist Full agonist 6.7
MRS2782 Agonist Full agonist 6.18
5BrUTP Agonist Partial agonist 6.1
ADP Gating inhibitor Antagonist 5.7
UTP Agonist Full agonist 5.2
reactive blue-2 Antagonist Antagonist 5
2MeSATP Agonist Full agonist 4.3

(19) Novoseek inferred chemical compound relationships for P2RY6 Gene

Compound -log(P) Hits PubMed IDs
udpbetas 87.8 3
uridine diphosphate 84.1 10
bzatp 80 1
alpha,beta methylene atp 74.7 1
adpbetas 72.5 1
genes like me logo Genes that share compounds with P2RY6: view

Transcripts for P2RY6 Gene

Unigene Clusters for P2RY6 Gene

Pyrimidinergic receptor P2Y, G-protein coupled, 6:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for P2RY6

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY6 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f · 6g
SP1: - - - - -
SP2: - - - -
SP3: - - -
SP4: -
SP5: - - - - -
SP6: - - - - - -
SP7: - -
SP8: -

Relevant External Links for P2RY6 Gene

GeneLoc Exon Structure for
P2RY6
ECgene alternative splicing isoforms for
P2RY6

Expression for P2RY6 Gene

mRNA expression in normal human tissues for P2RY6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY6 Gene

This gene is overexpressed in Spleen (15.7).

SOURCE GeneReport for Unigene cluster for P2RY6 Gene Hs.16362

genes like me logo Genes that share expressions with P2RY6: view

In Situ Assay Products

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for P2RY6 Gene

Orthologs for P2RY6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY6 35
  • 99.09 (n)
  • 99.39 (a)
P2RY6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia P2RY6 35
  • 89.53 (n)
  • 92.68 (a)
P2RY6 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY6 35
  • 88.62 (n)
  • 94.15 (a)
P2RY6 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia P2ry6 35
  • 84.15 (n)
  • 87.12 (a)
P2ry6 16
P2ry6 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia P2RY6 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2ry6 35
  • 84.56 (n)
  • 88.04 (a)
chicken
(Gallus gallus)
Aves P2RY3 36
  • 62 (a)
OneToOne
P2RY6 35
  • 70.2 (n)
  • 63.67 (a)
lizard
(Anolis carolinensis)
Reptilia P2RY6 36
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7925 35
zebrafish
(Danio rerio)
Actinopterygii LOC566099 35
  • 60.85 (n)
  • 61.59 (a)
P2RY6 36
  • 58 (a)
OneToOne
Species with no ortholog for P2RY6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY6 Gene

ENSEMBL:
Gene Tree for P2RY6 (if available)
TreeFam:
Gene Tree for P2RY6 (if available)

Paralogs for P2RY6 Gene

genes like me logo Genes that share paralogs with P2RY6: view

Variants for P2RY6 Gene

Sequence variations from dbSNP and Humsavar for P2RY6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs623194 -- 73,293,932(-) AGAGG(G/T)TTGTG intron-variant
rs623627 -- 73,293,838(-) GACAG(C/T)CCTCT intron-variant
rs868175 -- 73,288,041(+) TCTTC(A/G)TTCAC intron-variant
rs882904 -- 73,286,865(-) CATGA(C/T)ACCCT intron-variant
rs1045124 -- 73,297,661(+) TATTT(C/T)TTCAG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for P2RY6 Gene

Variant ID Type Subtype PubMed ID
nsv832208 CNV Gain 17160897
nsv387 CNV Insertion 18451855
nsv520665 CNV Loss 19592680

Relevant External Links for P2RY6 Gene

HapMap Linkage Disequilibrium report
P2RY6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY6 Gene

Disorders for P2RY6 Gene

(4) Novoseek inferred disease relationships for P2RY6 Gene

Disease -log(P) Hits PubMed IDs
astrocytoma 66 6
glioma 24.7 4
necrosis 0 1
tumors 0 2

Relevant External Links for P2RY6

Genetic Association Database (GAD)
P2RY6
Human Genome Epidemiology (HuGE) Navigator
P2RY6
genes like me logo Genes that share disorders with P2RY6: view

No data available for UniProtKB/Swiss-Prot for P2RY6 Gene

Publications for P2RY6 Gene

  1. Cloning, functional expression and tissue distribution of the human P2Y6 receptor. (PMID: 8670200) Communi D. … Boeynaems J.-M. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23
  2. Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. (PMID: 9268704) Maier R. … Bilbe G. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  3. Cloning of P2Y6 cDNAs and identification of a pseudogene: comparison of P2Y receptor subtype expression in bone and brain tissues. (PMID: 9412455) Maier R. … Bilbe G. (Biochem. Biophys. Res. Commun. 1997) 3 4 23
  4. Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. Ser-333 and Ser-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor. (PMID: 11114308) Brinson A.E. … Harden T.K. (J. Biol. Chem. 2001) 3 23
  5. Attenuation of signal flow from P2Y6 receptor by protein kinase C-alpha in SK-N-BE(2)C human neuroblastoma cells. (PMID: 12716436) Lee H. … Kim K.T. (J. Neurochem. 2003) 3 23

Products for P2RY6 Gene

Sources for P2RY6 Gene

Back to Top

Content