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P2RY5 Gene

protein-coding   GIFtS: 54

GC13M047884
purinergic receptor P2Y, G-protein coupled, 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
LAH3 2, 5
MGC120358 2
OTTHUMP00000018396 2
P2Y5 1, 2, 3, 5
Descriptions
G-protein coupled purinergic receptor P2Y5 2
P2Y purinoceptor 5 2, 3
Purinergic receptor 5 2, 3
RB intron encoded G-protein coupled receptor 2, 3
purinergic receptor P2Y, G-protein coupled, 5 2
External Ids
HGNC: 155201
Entrez Gene: 101612
UniProtKB: P436573
Ensembl: ENSG000001396797
Search outside databases for aliases for P2RY5 gene

Previous GC identifers: GC13M042972 GC13M047922 GC13M046783

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for P2RY5:
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are
preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal
intron of the retinoblastoma susceptibility gene in the reverse orientation. [provided by RefSeq]

UniProtKB/Swiss-Prot: P2RY5_HUMAN, P43657
Function: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in
the receptor activation. Important for the maintenance of hair growth and texture

Gene Wiki entry for P2RY5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the P2RY5 gene  

Entrez Gene cytogenetic band: 13q14   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14

P2RY5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M047884:     (about GC identifiers)

Start:
47,883,182 bp from pter
End:
47,916,841 bp from pter
Size:
33,660 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000013.9  NT_024524.13  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: P2RY5_HUMAN, P43657 (See protein sequence)
Recommended Name: Oleoyl-L-alpha-lysophosphatidic acid receptor  
Size: 344 amino acids; 39392 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Developmental stage: Markedly up-regulated in promyelocytic HL60 cells induced to differentiate
along the monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low
levels after the induction of differentiation along the granulocytic pathway
Miscellaneous: This is a nested gene within intron 17 of the retinoblastoma gene
Sequence caution: Sequence=L11910; Type=Frameshift; Positions=31;
Secondary accessions: A4FTW9 B3KVF2 O15133 Q3KPF5 Q53FA0 Q5VW44 Q7Z3S0 Q7Z3S6

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005758.2  

    ENSEMBL proteins: 
    ENSP00000344353 ENSP00000367691 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse Abcam for Recombinant Proteins
    Human Recombinant Proteins from Abnova (P2RY5)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane NAS--
    About this table

    Antibodies for P2RY5: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for P2RY5
    Browse R&D Systems for Antibodies
    Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for P2RY5

    Assays for P2RY5: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_supfam
     IPR002188 P2Y5_purnocptor
     IPR000276 7TM_GPCR_Rhodpsn


       GeneDecks  P2RY5 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P43657

    ProtoNet protein and cluster: P43657

    2 Blocks protein families:
    IPB002188 P2Y5 purinoceptor signature
    IPB002286 P2 purinoceptor signature


    UniProtKB/Swiss-Prot: P2RY5_HUMAN, P43657
    Similarity: Belongs to the G-protein coupled receptor 1 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (P2RY5)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (P2RY5)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005767

                  Applied Biosystems Silencer® siRNAs for P2RY5

                  Sigma-Aldrich siRNA and siRNA Panels for P2RY5  
                         Sigma-Aldrich shRNA Panels and shRNA for P2RY5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for P2RY5
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005767
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005767
                                     untagged cDNA clone in CMV expression vector: NM_005767 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_005767

    UniProtKB/Swiss-Prot: P2RY5_HUMAN, P43657
    Function: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in
    the receptor activation. Important for the maintenance of hair growth and texture

    3 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0004930 G-protein coupled receptor activity NAS--
    GO:0045028 purinergic nucleotide receptor activity, G-protein coupled IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Kegg Pathway  (Kegg details for P2RY5):
     hsa04080 Neuroactive ligand-receptor interaction

       GeneDecks  P2RY5 for the pathways selected above  
    About GeneDecksing

    4 Interacting proteins for P2RY5 (ENSP000003676913) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    P2RX4ENSP000003366073STRING (score=.751)
    RB1ENSP000002671633STRING (score=.747)
    P2RX5ENSP000003712553STRING (score=.74)
    RCBTB2ENSP000003451443STRING (score=.706)
    About this table

    2 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165 signal transduction IEA--
    GO:0007186 G-protein coupled receptor protein signaling pathway NAS--
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Sigma-Aldrich Small Molecules for P2RY5:
    Antagonist Agonist

    Compounds for P2RY5 available from Tocris Bioscience
    CompoundAction CAS number
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    2-Methylthioadenosine triphosphate tetrasodium saltP2 purinergic agonist[43170-89-4]
    PPADS tetrasodium saltP2 purinergic antagonist[149017-66-3]
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (P2RY5)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (P2RY5)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005767

                  Sigma-Aldrich siRNA and siRNA Panels for P2RY5  
                         Sigma-Aldrich shRNA Panels and shRNA for P2RY5  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_005767  

    REFSEQ mRNAs for P2RY5 gene: 

    NM_005767.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_005767  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_005767
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_005767
                                     untagged cDNA clone in CMV expression vector: NM_005767 

    Additional cDNA sequence: 

    AF000546.1 AK122856.1 AK123059.1 AK223389.1 BC040850.1 BC045651.1 BC054346.1 BC070295.1 
    BC106756.2 BX537392.1 BX537438.1 BX537445.1 BX647109.1 CR597194.1 

    12 DOTS entries:

    DT.448049  DT.101983571  DT.95145780  DT.95150078  DT.91955771  DT.120781599  DT.120781643  DT.120781901 
    DT.120781905  DT.40131251  DT.92416256  DT.92456735 

    24/139 AceView cDNA sequences (see all 139 ):

    BC040850 CD722586 BC045651 BP381270 AV715405 AI051863 AK122856 AA194811 
    AI523026 AI148328 BE217944 NM_005767 AL709780 BC054346 BX537392 BQ950264 
    BC070295 AA194998 AV711699 BX647109 BU752648 BX956559 CR597194 BQ006077 

    highest scoring ESTs for P2RY5:

    AA197280 AA812590 AI024338 AK122856 BC045651 AA194998 AA358246 AA650037 AA779703 AA780337 

    Unigene Cluster for P2RY5:

    Purinergic receptor P2Y, G-protein coupled, 5
    Hs.123464  [show with all ESTs]
    Unigene Representative Sequence: BC045651


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000345941  ENST00000378434  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    P2RY5 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for P2RY5

    1 / 2 / 3

    7 probe-sets matching P2RY5 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    76582_g_at2, 3 U95-D 1 1.00 1.00 0.53 0.88 AA812590 0.80 1.00 0.91 1
    75361_r_at2, 3 U95-D 1 0.94 1.00 0.56 0.92 AA197280 0.80 1.00 0.91 1

    76580_at2, 3 U95-D 1 0.88 1.00 -0.13 1.26 AA812590 0.80 1.00 0.91 1
    76584_r_at2, 3 U95-D 1 0.75 1.00 0.78 0.97 AI024338 0.80 1.00 0.91 1

    218589_at2, 3 U133-A 1 1.00 1.00 -- -- NM_005767 0.60 1.00 0.82 1

    1557763_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    218589_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  P2RY5 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TATTTTATTT

    SOURCE GeneReport for Unigene cluster: Hs.123464

    UniProtKB/Swiss-Prot: P2RY5_HUMAN, P43657
    Tissue specificity: Expressed ubiquitously, including in skin and hair follicle cells. Detected in
    both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal
    layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for P2RY5 gene from 5/6 species (see all 6 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    P2RY51   -- purinergic receptor P2Y, G-protein coupled, 5 100(n)
    100(a)
    741241  XM_001151666.1  XP_001151666.1 
    cow
    (Bos taurus)
    P2RY51   -- purinergic receptor P2Y, G-protein coupled, 5 87.91(n)
    89.68(a)
    782518  XM_001250744.1  XP_001250745.1 
    rat
    (Rattus norvegicus)
    P2ry51   -- purinergic receptor P2Y, G-protein coupled, 5 87.17(n)
    93.29(a)
    691774  XM_001076218.1  XP_001076218.1 
    mouse
    (Mus musculus)
    P2ry51, 5 145
    purinergic receptor P2Y, G-protein coupled, 51, 5 87.76(n)1
    93.29(a)1
    671681  NM_175116.31  NP_780325.11 
     AI7852645  AK0089525  (see all 14)
    chicken
    (Gallus gallus)
    P2RY51   -- purinergic receptor P2Y, G-protein coupled, 5 72.6(n)
    82.53(a)
    396118  NM_205199.1  NP_990530.1 
    About this table        Species with no ortholog for P2RY5

    ENSEMBL Gene Tree for P2RY5
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for P2RY5 gene
    LPAR42  GPR1742  P2RY102  LPAR52  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

      --
    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 609239   disorders: 611452  278150  

    UniProtKB/Swiss-Prot: P2RY5_HUMAN, P43657

  • Defects in P2RY5 are a cause of autosomal recessive woolly hair (ARWH) [MIM:278150].
    Woolly hair refers to a phenotypic variant with fine and tightly curled hair
  • Defects in P2RY5 are the cause of localized autosomal recessive hypotrichosis type 3
    (LAH3) [MIM:611452]. LAH3 is a form of hereditary isolated alopecia characterized by diffuse and
    progressive hair loss, usually beginning in early childhood
  • Human Gene Mutation Database: P2RY5

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/19 PubMed articles for P2RY5 gene (see all 19 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 10161 HGNC: 15520 AceView: P2RY5 Ensembl:ENSG00000139679 euGenes: HUgn10161
    ECgene: P2RY5 H-InvDB: P2RY5
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for P2RY5 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for P2RY5:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for P2RY5 Antibodies for P2RY5
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for P2RY5 Small molecules for P2RY5
     "Your Favorite Gene" Pathwaysfeedback


      
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     Search Novus for antibodies for P2RY5

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