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Aliases & Descriptions for P2RY5
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| LAH3 2, 5 | | MGC120358 2 | | OTTHUMP00000018396 2 | | P2Y5 1, 2, 3, 5 |
| | | Descriptions |
|---|
| G-protein coupled purinergic receptor P2Y5 2 | | P2Y purinoceptor 5 2, 3 | | Purinergic receptor 5 2, 3 | | RB intron encoded G-protein coupled receptor 2, 3 | | purinergic receptor P2Y, G-protein coupled, 5 2 |
|
| | Search outside databases for aliases for P2RY5 genePrevious GC identifers: GC13M042972 GC13M047922 GC13M046783 |
Summaries for P2RY5(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for P2RY5: The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. [provided by RefSeq] UniProtKB/Swiss-Prot: P2RY5_HUMAN, P43657Function: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and textureGene Wiki entry for P2RY5 |
Genomic Location for P2RY5
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the P2RY5 gene 
Entrez Gene cytogenetic band: 13q14 Ensembl cytogenetic band: 13q14.2 HGNC cytogenetic band: 13q14P2RY5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13M047884:
(about GC identifiers)
Start:
|
47,883,182 bp from pter |
End:
|
47,916,841 bp from pter |
Size:
|
33,660 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000013.9 NT_024524.13
| Proteins for P2RY5
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: P2RY5_HUMAN, P43657 (See
protein sequence)Recommended Name: Oleoyl-L-alpha-lysophosphatidic acid receptor Size: 344 amino acids; 39392 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Developmental stage: Markedly up-regulated in promyelocytic HL60 cells induced to differentiate along the monocyte/macrophage pathway. Not detectable in undifferentiated HL60 cells and only low levels after the induction of differentiation along the granulocytic pathway
Miscellaneous: This is a nested gene within intron 17 of the retinoblastoma gene
Sequence caution: Sequence=L11910; Type=Frameshift; Positions=31;
Secondary accessions: A4FTW9 B3KVF2 O15133 Q3KPF5 Q53FA0 Q5VW44 Q7Z3S0 Q7Z3S6Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005758.2
ENSEMBL proteins: ENSP00000344353 ENSP00000367691
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0016021 | integral to membrane |
NAS | -- | About this table
Antibodies for P2RY5: Assays for P2RY5: | Protein
Domains/ Families for P2RY5(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P43657
ProtoNet protein and cluster: P43657 2 Blocks protein families: IPB002188 P2Y5 purinoceptor signature IPB002286 P2 purinoceptor signature
UniProtKB/Swiss-Prot: P2RY5_HUMAN, P43657Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function for P2RY5
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005767
Applied Biosystems Silencer® siRNAs for P2RY5
Sigma-Aldrich siRNA and siRNA Panels for P2RY5  Sigma-Aldrich shRNA Panels and shRNA for P2RY5  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005767                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005767                                  untagged cDNA clone in CMV expression vector: NM_005767 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005767
UniProtKB/Swiss-Prot: P2RY5_HUMAN, P43657Function: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
IEA | -- | | GO:0004930 | G-protein coupled receptor activity |
NAS | -- | | GO:0045028 | purinergic nucleotide receptor activity, G-protein coupled |
IEA | -- | About this table | Pathways & Interactions for P2RY5
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
4 Interacting proteins for P2RY5 (ENSP000003676913) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007165 | signal transduction |
IEA | -- | | GO:0007186 | G-protein coupled receptor protein signaling pathway |
NAS | -- | About this table
|
Drugs & Compounds for P2RY5(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for P2RY5 available from Tocris Bioscience About this table
|
Transcripts for P2RY5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005767
Sigma-Aldrich siRNA and siRNA Panels for P2RY5  Sigma-Aldrich shRNA Panels and shRNA for P2RY5  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005767 REFSEQ mRNAs for P2RY5 gene: NM_005767.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005767               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005767                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005767                                  untagged cDNA clone in CMV expression vector: NM_005767  Additional cDNA sequence: AF000546.1 AK122856.1 AK123059.1 AK223389.1 BC040850.1 BC045651.1 BC054346.1 BC070295.1 BC106756.2 BX537392.1 BX537438.1 BX537445.1 BX647109.1 CR597194.1 12 DOTS entries: DT.448049 DT.101983571 DT.95145780 DT.95150078 DT.91955771 DT.120781599 DT.120781643 DT.120781901 DT.120781905 DT.40131251 DT.92416256 DT.92456735 24/139 AceView cDNA sequences (see all 139
):BC040850 CD722586 BC045651 BP381270 AV715405 AI051863 AK122856 AA194811 AI523026 AI148328 BE217944 NM_005767 AL709780 BC054346 BX537392 BQ950264 BC070295 AA194998 AV711699 BX647109 BU752648 BX956559 CR597194 BQ006077
highest scoring ESTs for P2RY5:AA197280 AA812590 AI024338 AK122856 BC045651 AA194998 AA358246 AA650037 AA779703 AA780337 Unigene Cluster for P2RY5: Purinergic receptor P2Y, G-protein coupled, 5 Hs.123464 [show with all ESTs]Unigene Representative Sequence: BC045651
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000345941
ENST00000378434
|
Expression for P2RY5
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| P2RY5 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for P2RY5
1 / 2 / 3 7 probe-sets matching P2RY5 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TATTTTATTT
SOURCE GeneReport for Unigene cluster: Hs.123464 UniProtKB/Swiss-Prot: P2RY5_HUMAN, P43657Tissue specificity: Expressed ubiquitously, including in skin and hair follicle cells. Detected in both Henle's and Huxley's layers of the inner root sheath of the hair follicle and in suprabasal layers of the epidermis (at protein level). Expressed at low levels in peripheral blood leukocytes |
Orthologs for P2RY5
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for P2RY5 gene from 5/6 species (see all 6
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
chimpanzee (Pan troglodytes) |
P2RY51 |
-- |
purinergic receptor P2Y, G-protein coupled, 5 |
100(n) 100(a) |
741241 XM_001151666.1 XP_001151666.1 |
cow (Bos taurus) |
P2RY51 |
-- |
purinergic receptor P2Y, G-protein coupled, 5 |
87.91(n) 89.68(a) |
782518 XM_001250744.1 XP_001250745.1 |
rat (Rattus norvegicus) |
P2ry51 |
-- |
purinergic receptor P2Y, G-protein coupled, 5 |
87.17(n) 93.29(a) |
691774 XM_001076218.1 XP_001076218.1 |
mouse (Mus musculus) |
P2ry51, 5 |
145
|
purinergic receptor P2Y, G-protein coupled, 51, 5 |
87.76(n)1 93.29(a)1 |
671681 NM_175116.31 NP_780325.11 AI7852645 AK0089525 (see all 14) |
chicken (Gallus gallus) |
P2RY51 |
-- |
purinergic receptor P2Y, G-protein coupled, 5 |
72.6(n) 82.53(a) |
396118 NM_205199.1 NP_990530.1 |
About this table Species with no ortholog for P2RY5
ENSEMBL Gene Tree for P2RY5 | Paralogs for P2RY5(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for P2RY5 gene
- LPAR42 GPR1742 P2RY102 LPAR52
|
SNPs/Variants for P2RY5(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| -- |
Disorders & Mutations for P2RY5
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 609239 disorders: 611452 278150 UniProtKB/Swiss-Prot: P2RY5_HUMAN, P43657
Defects in P2RY5 are a cause of autosomal recessive woolly hair (ARWH) [MIM:278150]. Woolly hair refers to a phenotypic variant with fine and tightly curled hair Defects in P2RY5 are the cause of localized autosomal recessive hypotrichosis type 3 (LAH3) [MIM:611452]. LAH3 is a form of hereditary isolated alopecia characterized by diffuse and progressive hair loss, usually beginning in early childhoodHuman Gene Mutation Database: P2RY5
|
Medical News for P2RY5(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for P2RY5 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/19 PubMed articles for P2RY5 gene (see all 19
):- Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PubMed id 11004484)2, 3, 4 Adrian K.... Ogilvie A. (2000)
- G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. (PubMed id 18297070)3, 4 Pasternack S.M.... Betz R.C. (2008)
- Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. (PubMed id 18297072)3, 4 Shimomura Y....Christiano A.M. (2008)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)3, 4 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- Receptors for purines and pyrimidines. (PubMed id 9755289)2, 3 Ralevic V. and Burnstock G. (1998)
- Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene. (PubMed id 8889552)3, 4 Herzog H.... Shine J. (1996)
- Complete genomic sequence of the human retinoblastoma susceptibility gene. (PubMed id 7902321)3, 4 Toguchida J.... Dryja T.P. (1993)
- ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts. (PubMed id 15582581)1, 3 Ihara H....Togari A. (2005)
|
Search for P2RY5
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing P2RY5
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing P2RY5
(According to HUGE)
About This Section
| -- |
Specialized Databases showing P2RY5(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for P2RY5(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for P2RY5:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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