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Aliases for P2RY4 Gene

Aliases for P2RY4 Gene

  • Pyrimidinergic Receptor P2Y4 2 3
  • Pyrimidinergic Receptor P2Y, G-Protein Coupled, 4 2 3 5
  • Uridine Nucleotide Receptor 3 4
  • P2Y4 3 4
  • UNR 3 4
  • NRU 3 4
  • P2P 3 4

External Ids for P2RY4 Gene

Previous GeneCards Identifiers for P2RY4 Gene

  • GC0XM065656
  • GC0XM066955
  • GC0XM067711
  • GC0XM068345
  • GC0XM069261
  • GC0XM069394
  • GC0XM069478
  • GC0XM063299

Summaries for P2RY4 Gene

Entrez Gene Summary for P2RY4 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY4 Gene

P2RY4 (Pyrimidinergic Receptor P2Y4) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Nucleotide-like (purinergic) receptors. GO annotations related to this gene include G-protein coupled receptor activity and uridine nucleotide receptor activity. An important paralog of this gene is P2RY2.

UniProtKB/Swiss-Prot for P2RY4 Gene

  • Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.

Tocris Summary for P2RY4 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY4 Gene

Genomics for P2RY4 Gene

Regulatory Elements for P2RY4 Gene

Enhancers for P2RY4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around P2RY4 on UCSC Golden Path with GeneCards custom track

Genomic Location for P2RY4 Gene

70,258,166 bp from pter
70,259,804 bp from pter
1,639 bases
Minus strand

Genomic View for P2RY4 Gene

Genes around P2RY4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY4 Gene

Proteins for P2RY4 Gene

  • Protein details for P2RY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    P2Y purinoceptor 4
    Protein Accession:
    Secondary Accessions:
    • Q4VBB7
    • Q4VBB8
    • Q502W2
    • Q5JT22

    Protein attributes for P2RY4 Gene

    365 amino acids
    Molecular mass:
    40963 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY4 Gene

neXtProt entry for P2RY4 Gene

Proteomics data for P2RY4 Gene at MOPED

Post-translational modifications for P2RY4 Gene

  • Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for P2RY4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for P2Y4

No data available for DME Specific Peptides for P2RY4 Gene

Domains & Families for P2RY4 Gene

Gene Families for P2RY4 Gene

Protein Domains for P2RY4 Gene

Suggested Antigen Peptide Sequences for P2RY4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY4: view

Function for P2RY4 Gene

Molecular function for P2RY4 Gene

GENATLAS Biochemistry:
purinoceptor P2Y type 4,group 3,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly responding to UTP,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.

Gene Ontology (GO) - Molecular Function for P2RY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY4: view
genes like me logo Genes that share phenotypes with P2RY4: view

Animal Models for P2RY4 Gene

MGI Knock Outs for P2RY4:

Animal Model Products

  • Taconic Biosciences Mouse Models for P2RY4

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RY4 Gene

Localization for P2RY4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for P2RY4 Gene COMPARTMENTS Subcellular localization image for P2RY4 gene
Compartment Confidence
plasma membrane 5
cytosol 4
extracellular 2

Gene Ontology (GO) - Cellular Components for P2RY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with P2RY4: view

Pathways & Interactions for P2RY4 Gene

genes like me logo Genes that share pathways with P2RY4: view

Pathways by source for P2RY4 Gene

Interacting Proteins for P2RY4 Gene

Gene Ontology (GO) - Biological Process for P2RY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 8537336
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with P2RY4: view

No data available for SIGNOR curated interactions for P2RY4 Gene

Drugs & Compounds for P2RY4 Gene

(22) Drugs for P2RY4 Gene - From: DGIdb, IUPHAR, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental Pharma 0
Denufosol Investigational Pharma 0
MC-1 Investigational Pharma 0
ATP Pharma Agonist 0

(21) Additional Compounds for P2RY4 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Partial agonist, Agonist
Partial agonist, Agonist
Full agonist, Agonist
Full agonist, Agonist
Full agonist, Agonist

(5) Tocris Compounds for P2RY4 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
2-Methylthioadenosine triphosphate tetrasodium salt P2 purinergic agonist 100020-57-3
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
genes like me logo Genes that share compounds with P2RY4: view

Transcripts for P2RY4 Gene

mRNA/cDNA for P2RY4 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for P2RY4 Gene

Pyrimidinergic receptor P2Y, G-protein coupled, 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY4 Gene

No ASD Table

Relevant External Links for P2RY4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for P2RY4 Gene

mRNA expression in normal human tissues for P2RY4 Gene

mRNA differential expression in normal tissues according to GTEx for P2RY4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x6.2) and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for P2RY4 Gene

SOURCE GeneReport for Unigene cluster for P2RY4 Gene Hs.673854

mRNA Expression by UniProt/SwissProt for P2RY4 Gene

Tissue specificity: Pancreas.
genes like me logo Genes that share expression patterns with P2RY4: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues and Protein tissue co-expression partners for P2RY4 Gene

Orthologs for P2RY4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia P2RY4 35
  • 85.3 (n)
  • 84.38 (a)
P2RY4 36
  • 84 (a)
(Canis familiaris)
Mammalia P2RY4 35
  • 84.67 (n)
  • 78.06 (a)
-- 36
  • 39 (a)
(Mus musculus)
Mammalia P2ry4 35
  • 83.67 (n)
  • 82.52 (a)
P2ry4 16
P2ry4 36
  • 82 (a)
(Pan troglodytes)
Mammalia P2RY4 35
  • 98.36 (n)
  • 97.98 (a)
P2RY4 36
  • 99 (a)
(Rattus norvegicus)
Mammalia P2ry4 35
  • 83.86 (n)
  • 84.24 (a)
(Monodelphis domestica)
Mammalia P2RY4 36
  • 81 (a)
(Gallus gallus)
Aves LOC100857687 35
  • 66.56 (n)
  • 62.58 (a)
P2RY4 36
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry4 35
  • 60.38 (n)
  • 59.93 (a)
African clawed frog
(Xenopus laevis)
Amphibia p2ry4-prov 35
(Danio rerio)
Actinopterygii pr2y4l 35
  • 61.64 (n)
  • 61.64 (a)
pr2y4l 36
  • 56 (a)
Species with no ortholog for P2RY4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY4 Gene

Gene Tree for P2RY4 (if available)
Gene Tree for P2RY4 (if available)

Paralogs for P2RY4 Gene

genes like me logo Genes that share paralogs with P2RY4: view

Variants for P2RY4 Gene

Sequence variations from dbSNP and Humsavar for P2RY4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
VAR_011854 -
VAR_011855 -
VAR_011856 -
VAR_049429 -

Structural Variations from Database of Genomic Variants (DGV) for P2RY4 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv519108 CNV Loss 19592680
nsv525258 CNV Gain 19592680

Variation tolerance for P2RY4 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.22; 69.91% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for P2RY4 Gene

Disorders for P2RY4 Gene

Relevant External Links for P2RY4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for P2RY4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for P2RY4 Gene

Publications for P2RY4 Gene

  1. Cloning and functional expression of a human uridine nucleotide receptor. (PMID: 8537336) Communi D. … Boeynaems J.-M. (J. Biol. Chem. 1995) 2 3 4 23 67
  2. ATP modulates transcription factors through P2Y2 and P2Y4 receptors via PKC/MAPKs and PKC/Src pathways in MCF-7 cells. (PMID: 19900397) Scodelaro Bilbao P. … Santillan G. (Arch. Biochem. Biophys. 2010) 3 23
  3. Extracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell line. (PMID: 19836435) Buzzi N. … de Boland A.R. (Biochim. Biophys. Acta 2009) 3 23
  4. The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells. (PMID: 15649700) Cavaliere F. … VolontAc C. (Neurobiol. Dis. 2005) 3 23
  5. Agonist versus antagonist action of ATP at the P2Y4 receptor is determined by the second extracellular loop. (PMID: 14670966) Herold C.L. … Nicholas R.A. (J. Biol. Chem. 2004) 3 23

Products for P2RY4 Gene

Sources for P2RY4 Gene