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Aliases for P2RY4 Gene

Aliases for P2RY4 Gene

  • Pyrimidinergic Receptor P2Y4 2 3 5
  • Pyrimidinergic Receptor P2Y, G-Protein Coupled, 4 2 3
  • Uridine Nucleotide Receptor 3 4
  • P2Y4 3 4
  • UNR 3 4
  • NRU 3 4
  • P2P 3 4
  • P2Y Purinoceptor 4 3

External Ids for P2RY4 Gene

Previous GeneCards Identifiers for P2RY4 Gene

  • GC0XM065656
  • GC0XM066955
  • GC0XM067711
  • GC0XM068345
  • GC0XM069261
  • GC0XM069394
  • GC0XM069478
  • GC0XM063299

Summaries for P2RY4 Gene

Entrez Gene Summary for P2RY4 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY4 Gene

P2RY4 (Pyrimidinergic Receptor P2Y4) is a Protein Coding gene. Among its related pathways are Nucleotide-like (purinergic) receptors and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and uridine nucleotide receptor activity. An important paralog of this gene is P2RY2.

UniProtKB/Swiss-Prot for P2RY4 Gene

  • Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.

Tocris Summary for P2RY4 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY4 Gene

Additional gene information for P2RY4 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY4 Gene

Genomics for P2RY4 Gene

GeneHancer (GH) Regulatory Elements for P2RY4 Gene

Promoters and enhancers for P2RY4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI070259 Promoter 0.5 EPDnew 550.8 -0.1 -74 0.1 P2RY4 ARR3
GH0XI071181 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 29.3 -923.1 -923067 3.5 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B TAF1 NONO MED12 OGT LOC100420758 ENSG00000229601 P2RY4 ARR3 RPS26P11 RTL5
GH0XI071250 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.3 -994.0 -993983 6.1 HDGF PKNOX1 ARNT NEUROD1 SIN3A FEZF1 ZNF2 YY1 ZNF766 ZNF213 ZMYM3 LOC105373247 TAF1 LOC100420758 MED12 NONO OGT ERCC6L ARR3 ENSG00000229601
GH0XI070288 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 10.1 -30.5 -30483 2.6 ATF1 ARID4B SIN3A ETS1 POLR2B GLIS2 ELK1 KLF7 RUNX3 SP3 KIF4A PDZD11 MED12 NONO IGBP1 P2RY4 ARR3
GH0XI071145 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 10.5 -886.4 -886360 1.9 HDGF ATF1 FOXA2 ARNT ZNF493 TCF12 POLR2B GLIS2 E2F8 KLF7 NLGN3 MED12 LOC392489 TAF1 NONO ZMYM3 LOC100420758 ARR3 P2RY4 OGT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around P2RY4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the P2RY4 gene promoter:

Genomic Locations for P2RY4 Gene

Genomic Locations for P2RY4 Gene
chrX:70,258,166-70,259,804
(GRCh38/hg38)
Size:
1,639 bases
Orientation:
Minus strand
chrX:69,478,016-69,479,654
(GRCh37/hg19)

Genomic View for P2RY4 Gene

Genes around P2RY4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY4 Gene

Proteins for P2RY4 Gene

  • Protein details for P2RY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51582-P2RY4_HUMAN
    Recommended name:
    P2Y purinoceptor 4
    Protein Accession:
    P51582
    Secondary Accessions:
    • Q4VBB7
    • Q4VBB8
    • Q502W2
    • Q5JT22

    Protein attributes for P2RY4 Gene

    Size:
    365 amino acids
    Molecular mass:
    40963 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY4 Gene

neXtProt entry for P2RY4 Gene

Post-translational modifications for P2RY4 Gene

  • Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.

Other Protein References for P2RY4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for P2RY4 Gene

Domains & Families for P2RY4 Gene

Gene Families for P2RY4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for P2RY4 Gene

Suggested Antigen Peptide Sequences for P2RY4 Gene

Graphical View of Domain Structure for InterPro Entry

P51582

UniProtKB/Swiss-Prot:

P2RY4_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY4: view

Function for P2RY4 Gene

Molecular function for P2RY4 Gene

GENATLAS Biochemistry:
purinoceptor P2Y type 4,group 3,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly responding to UTP,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.

Gene Ontology (GO) - Molecular Function for P2RY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IEA --
GO:0005524 ATP binding IEA --
GO:0015065 uridine nucleotide receptor activity TAS 8537335
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
GO:0045030 UTP-activated nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY4: view
genes like me logo Genes that share phenotypes with P2RY4: view

Animal Models for P2RY4 Gene

MGI Knock Outs for P2RY4:

Animal Model Products

Clone Products

  • Addgene plasmids for P2RY4

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RY4 Gene

Localization for P2RY4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY4 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for P2RY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8537336
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
genes like me logo Genes that share ontologies with P2RY4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for P2RY4 Gene

Pathways & Interactions for P2RY4 Gene

genes like me logo Genes that share pathways with P2RY4: view

Pathways by source for P2RY4 Gene

Gene Ontology (GO) - Biological Process for P2RY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway TAS --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 8537336
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 8537335
GO:0030321 transepithelial chloride transport IEA --
genes like me logo Genes that share ontologies with P2RY4: view

No data available for SIGNOR curated interactions for P2RY4 Gene

Drugs & Compounds for P2RY4 Gene

(24) Drugs for P2RY4 Gene - From: DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
Guanosine triphosphate Experimental Pharma 0
Uridine triphosphate Experimental, Investigational Pharma 0
ATP Investigational Nutra Agonist 0
Denufosol Investigational Pharma 0

(19) Additional Compounds for P2RY4 Gene - From: Novoseek and IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-amino-uridine-5-monophosphate
Partial agonist, Agonist
gtp
Partial agonist, Agonist
N<sup>4</sup>-phenylethoxycytidine-5?a?-triphosphate
Full agonist, Agonist
Up<sub>4</sub>dC
Full agonist, Agonist
Up<sub>4</sub>U
Full agonist, Agonist

(5) Tocris Compounds for P2RY4 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2690 Potent P2Y14 agonist 15039-58-4
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
genes like me logo Genes that share compounds with P2RY4: view

Transcripts for P2RY4 Gene

mRNA/cDNA for P2RY4 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for P2RY4 Gene

Pyrimidinergic receptor P2Y, G-protein coupled, 4:
Representative Sequences:

Clone Products

  • Addgene plasmids for P2RY4

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY4 Gene

No ASD Table

Relevant External Links for P2RY4 Gene

GeneLoc Exon Structure for
P2RY4
ECgene alternative splicing isoforms for
P2RY4

Expression for P2RY4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for P2RY4 Gene

mRNA differential expression in normal tissues according to GTEx for P2RY4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x6.2) and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for P2RY4 Gene



NURSA nuclear receptor signaling pathways regulating expression of P2RY4 Gene:

P2RY4

SOURCE GeneReport for Unigene cluster for P2RY4 Gene:

Hs.673854

mRNA Expression by UniProt/SwissProt for P2RY4 Gene:

P51582-P2RY4_HUMAN
Tissue specificity: Pancreas.

Evidence on tissue expression from TISSUES for P2RY4 Gene

  • Pancreas(4.2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with P2RY4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RY4 Gene

Orthologs for P2RY4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY4 33 34
  • 98.36 (n)
cow
(Bos Taurus)
Mammalia P2RY4 33 34
  • 85.3 (n)
dog
(Canis familiaris)
Mammalia P2RY4 33
  • 84.67 (n)
-- 34
  • 39 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia P2ry4 33
  • 83.86 (n)
mouse
(Mus musculus)
Mammalia P2ry4 33 16 34
  • 83.67 (n)
oppossum
(Monodelphis domestica)
Mammalia P2RY4 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857687 33
  • 66.56 (n)
P2RY4 34
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry4 33
  • 60.38 (n)
African clawed frog
(Xenopus laevis)
Amphibia p2ry4-prov 33
zebrafish
(Danio rerio)
Actinopterygii pr2y4l 33 34
  • 61.64 (n)
Species where no ortholog for P2RY4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY4 Gene

ENSEMBL:
Gene Tree for P2RY4 (if available)
TreeFam:
Gene Tree for P2RY4 (if available)

Paralogs for P2RY4 Gene

Paralogs for P2RY4 Gene

genes like me logo Genes that share paralogs with P2RY4: view

Variants for P2RY4 Gene

Sequence variations from dbSNP and Humsavar for P2RY4 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000313857 -- 70,261,719(-) C/T upstream_transcript_variant
rs1006048686 -- 70,260,360(-) C/A upstream_transcript_variant
rs1008944839 -- 70,260,825(-) C/T upstream_transcript_variant
rs1008997147 -- 70,261,295(-) A/G upstream_transcript_variant
rs1009168180 -- 70,260,760(-) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for P2RY4 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
nsv519108 CNV loss 19592680
nsv525258 CNV gain 19592680

Variation tolerance for P2RY4 Gene

Residual Variation Intolerance Score: 88.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.22; 69.91% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for P2RY4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
P2RY4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY4 Gene

Disorders for P2RY4 Gene

Additional Disease Information for P2RY4

No disorders were found for P2RY4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for P2RY4 Gene

Publications for P2RY4 Gene

  1. Cloning and functional expression of a human uridine nucleotide receptor. (PMID: 8537336) Communi D … Boeynaems JM (The Journal of biological chemistry 1995) 2 3 4 22 58
  2. Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. SER-333 and SER-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor. (PMID: 11114308) Brinson AE … Harden TK (The Journal of biological chemistry 2001) 3 4 22 58
  3. Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. (PMID: 8537335) Nguyen T … O'Dowd BF (The Journal of biological chemistry 1995) 3 4 22 58
  4. ATP modulates transcription factors through P2Y2 and P2Y4 receptors via PKC/MAPKs and PKC/Src pathways in MCF-7 cells. (PMID: 19900397) Scodelaro Bilbao P … Santillán G (Archives of biochemistry and biophysics 2010) 3 22 58
  5. Extracellular ATP activates MAP kinase cascades through a P2Y purinergic receptor in the human intestinal Caco-2 cell line. (PMID: 19836435) Buzzi N … de Boland AR (Biochimica et biophysica acta 2009) 3 22 58

Products for P2RY4 Gene

  • Addgene plasmids for P2RY4

Sources for P2RY4 Gene

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