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Aliases for P2RY4 Gene

Aliases for P2RY4 Gene

  • Pyrimidinergic Receptor P2Y, G-Protein Coupled, 4 2 3
  • P2Y4 3 4 6
  • NRU 3 4 6
  • Uridine Nucleotide Receptor 3 4
  • UNR 3 4
  • P2P 3 4
  • P2Y Purinoceptor 4 3

External Ids for P2RY4 Gene

Summaries for P2RY4 Gene

Entrez Gene Summary for P2RY4 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY4 Gene

P2RY4 (Pyrimidinergic Receptor P2Y, G-Protein Coupled, 4) is a Protein Coding gene. Among its related pathways are GPCR Pathway and Signaling by GPCR. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity and UTP-activated nucleotide receptor activity. An important paralog of this gene is PTAFR.

UniProtKB/Swiss-Prot for P2RY4 Gene

  • Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP

Tocris Summary for P2RY4 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10 receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4 receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13 and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They have diverse physiological roles including regulation of platelet aggregation, muscle contraction, neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY4 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY4 Gene

Genomics for P2RY4 Gene

Genomic Location for P2RY4 Gene

Start:
70,258,166 bp from pter
End:
70,259,804 bp from pter
Size:
1,639 bases
Orientation:
Minus strand

Genomic View for P2RY4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for P2RY4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY4 Gene

Proteins for P2RY4 Gene

  • Protein details for P2RY4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51582-P2RY4_HUMAN
    Recommended name:
    P2Y purinoceptor 4
    Protein Accession:
    P51582
    Secondary Accessions:
    • Q4VBB7
    • Q4VBB8
    • Q502W2
    • Q5JT22

    Protein attributes for P2RY4 Gene

    Size:
    365 amino acids
    Molecular mass:
    40963 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY4 Gene

neXtProt entry for P2RY4 Gene

Proteomics data for P2RY4 Gene at MOPED

Post-translational modifications for P2RY4 Gene

  • Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for P2RY4 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for P2RY4 Gene

Domains for P2RY4 Gene

Gene Families for P2RY4 Gene

HGNC:
  • P2R :Purinergic receptors
  • P2RY :GPCR / Class A : Purinergic receptors, P2Y
IUPHAR :

Protein Domains for P2RY4 Gene

Suggested Antigen Peptide Sequences for P2RY4 Gene

Graphical View of Domain Structure for InterPro Entry

P51582

UniProtKB/Swiss-Prot:

P2RY4_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • P51582
genes like me logo Genes that share domains with P2RY4: view

Function for P2RY4 Gene

Molecular function for P2RY4 Gene

GENATLAS Biochemistry: purinoceptor P2Y type 4,group 3,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly responding to UTP,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP

Gene Ontology (GO) - Molecular Function for P2RY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0005524 ATP binding IEA --
GO:0015065 uridine nucleotide receptor activity TAS 8537335
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
GO:0045030 UTP-activated nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY4: view

Phenotypes for P2RY4 Gene

MGI mutant phenotypes for P2RY4:
inferred from 1 alleles
GenomeRNAi human phenotypes for P2RY4:
genes like me logo Genes that share phenotypes with P2RY4: view

Animal Models for P2RY4 Gene

MGI Knock Outs for P2RY4:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for P2RY4 Gene

Localization for P2RY4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY4 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY4 Gene COMPARTMENTS Subcellular localization image for P2RY4 gene
Compartment Confidence
plasma membrane 5
extracellular 1

Gene Ontology (GO) - Cellular Components for P2RY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8537336
GO:0016021 integral component of membrane --
GO:0016323 basolateral plasma membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with P2RY4: view

Pathways for P2RY4 Gene

genes like me logo Genes that share pathways with P2RY4: view

Pathways by source for P2RY4 Gene

1 GeneGo (Thomson Reuters) pathway for P2RY4 Gene
1 Qiagen pathway for P2RY4 Gene
2 BioSystems pathways for P2RY4 Gene

Interacting Proteins for P2RY4 Gene

Gene Ontology (GO) - Biological Process for P2RY4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 8537336
GO:0007204 positive regulation of cytosolic calcium ion concentration TAS 8537335
GO:0030321 transepithelial chloride transport IEA --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with P2RY4: view

Compounds for P2RY4 Gene

(5) Tocris Compounds for P2RY4 Gene

Compound Action Cas Number
alpha,beta-Methyleneadenosine 5-triphosphate trisodium salt P2 agonist [7292-42-4]
MRS 2179 tetrasodium salt Selective P2Y1 antagonist [101204-49-3]
MRS 2365 Highly potent and selective P2Y1 agonist [436847-09-5]
MRS 2500 tetraammonium salt Extremely potent and selective P2Y1 antagonist [630103-23-0]
UTPgammaS trisodium salt Selective P2Y2/4 agonist [1266569-94-1]

(1) HMDB Compounds for P2RY4 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(12) IUPHAR Ligand for P2RY4 Gene

Ligand Type Action Affinity Pubmed IDs
MRS4062 Agonist Full agonist 7.6
MRS2927 Agonist Full agonist 7.21
N4-phenylethoxycytidine-5?a?-triphosphate Agonist Full agonist 7.14
(N)methanocarba-UTP Agonist Full agonist 7.1
Up4U Agonist Full agonist 6.4
Up4dC Agonist Full agonist 6.1
2-amino-uridine-5-monophosphate Agonist Partial agonist 5.3
UTP Agonist Full agonist 5.2
GTP Agonist Partial agonist 5.2
ITP Agonist Partial agonist 5.1
PPADS Antagonist Antagonist 5
ATP Activator None

(21) Novoseek inferred chemical compound relationships for P2RY4 Gene

Compound -log(P) Hits PubMed IDs
mrs2279 92.2 1
udpbetas 87.7 1
mrs2179 86.4 1
5-bromo-utp 85.5 1
2-methylthio-atp 80.8 1
genes like me logo Genes that share compounds with P2RY4: view

Transcripts for P2RY4 Gene

mRNA/cDNA for P2RY4 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for P2RY4 Gene

Pyrimidinergic receptor P2Y, G-protein coupled, 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY4 Gene

No ASD Table

Relevant External Links for P2RY4 Gene

GeneLoc Exon Structure for
P2RY4
ECgene alternative splicing isoforms for
P2RY4

Expression for P2RY4 Gene

mRNA expression in normal human tissues for P2RY4 Gene

mRNA differential expression in normal tissues according to GTEx for P2RY4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (6.2) and Skin - Not Sun Exposed (Suprapubic) (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for P2RY4 Gene

SOURCE GeneReport for Unigene cluster for P2RY4 Gene Hs.673854

mRNA Expression by UniProt/SwissProt for P2RY4 Gene

P51582-P2RY4_HUMAN
Tissue specificity: Pancreas
genes like me logo Genes that share expressions with P2RY4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for P2RY4 Gene

Orthologs for P2RY4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY4 35
  • 98.36 (n)
  • 97.98 (a)
P2RY4 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia P2RY4 35
  • 85.3 (n)
  • 84.38 (a)
P2RY4 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 39 (a)
ManyToMany
P2RY4 35
  • 84.67 (n)
  • 78.06 (a)
mouse
(Mus musculus)
Mammalia P2ry4 35
  • 83.67 (n)
  • 82.52 (a)
P2ry4 16
P2ry4 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia P2RY4 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2ry4 35
  • 83.86 (n)
  • 84.24 (a)
chicken
(Gallus gallus)
Aves LOC100857687 35
  • 66.56 (n)
  • 62.58 (a)
P2RY4 36
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia p2ry4-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry4 35
  • 60.38 (n)
  • 59.93 (a)
zebrafish
(Danio rerio)
Actinopterygii pr2y4l 35
  • 61.64 (n)
  • 61.64 (a)
pr2y4l 36
  • 56 (a)
OneToOne
Species with no ortholog for P2RY4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY4 Gene

ENSEMBL:
Gene Tree for P2RY4 (if available)
TreeFam:
Gene Tree for P2RY4 (if available)

Paralogs for P2RY4 Gene

genes like me logo Genes that share paralogs with P2RY4: view

Variants for P2RY4 Gene

Sequence variations from dbSNP and Humsavar for P2RY4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs1152185 -- 70,261,396(+) gttgt(C/T)gtttt upstream-variant-2KB
rs1152186 - 70,259,123(-) GCCTC(A/G)TGCCC missense, reference
rs1152187 - 70,259,092(+) CTTTG(G/T)TGCTG reference, missense
rs1152188 - 70,259,053(+) CTTCA(A/G)GCCGA reference, missense
rs1152189 -- 70,258,629(+) GAAGA(A/G)GCAGC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for P2RY4 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER Inversion 17803354
nsv519108 CNV Loss 19592680
nsv525258 CNV Gain 19592680

Relevant External Links for P2RY4 Gene

HapMap Linkage Disequilibrium report
P2RY4
Locus Specific Mutation Databases (LSDB)
P2RY4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY4 Gene

Disorders for P2RY4 Gene

(3) Novoseek inferred disease relationships for P2RY4 Gene

Disease -log(P) Hits PubMed IDs
astrocytoma 72 9
glioma 8.04 3
tumors 1.45 1
genes like me logo Genes that share disorders with P2RY4: view

No data available for UniProtKB/Swiss-Prot for P2RY4 Gene

Publications for P2RY4 Gene

  1. Cloning and functional expression of a human uridine nucleotide receptor. (PMID: 8537336) Communi D. … Boeynaems J.-M. (J. Biol. Chem. 1995) 2 3 4 23
  2. Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. Ser-333 and Ser-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor. (PMID: 11114308) Brinson A.E. … Harden T.K. (J. Biol. Chem. 2001) 3 4 23
  3. Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. (PMID: 8537335) Nguyen T. … O'Dowd B.F. (J. Biol. Chem. 1995) 3 4 23
  4. Molecular cloning and characterization of a novel orphan receptor (P2P) expressed in human pancreas that shows high structural homology to the P2U purinoceptor. (PMID: 8617367) Stam N.J. … Olijve W. (FEBS Lett. 1996) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for P2RY4 Gene

Sources for P2RY4 Gene

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