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P2RY4 Gene

protein-coding GIFtS: 54

GC0XM069394

pyrimidinergic receptor P2Y, G-protein coupled, 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
NRU ^¹, ², ³, ⁵
OTTHUMP00000023468 ^²
P2P ^¹, ², ³
P2Y4 ^¹, ², ³, ⁵
UNR ^¹, ², ³

Descriptions
P2Y purinoceptor 4 ^²
Uridine nucleotide receptor ^², ³
pyrimidinergic receptor P2Y, G-protein coupled, 4 ^²
pyrimidinergic receptor P2Y4 ^²

External Ids
HGNC: 8542¹
Entrez Gene: 5030²
UniProtKB: P51582³
Ensembl: ENSG00000186912⁷

Search outside databases for aliases for P2RY4 gene

Previous GC identifers: GC0XM065656 GC0XM066955 GC0XM067711 GC0XM068345 GC0XM069261

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for P2RY4:

The product of this gene belongs to the family of G-protein coupled receptors. This family has

several receptor subtypes with different pharmacological selectivity, which overlaps in some

cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine

nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq]

UniProtKB/Swiss-Prot: P2RY4_HUMAN, P51582

Function: Receptor for UTP and UDP coupled to G-proteins that activate a

phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP

Gene Wiki entry for P2RY4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the P2RY4 gene

Entrez Gene cytogenetic band: Xq13 Ensembl cytogenetic band: Xq13.1 HGNC cytogenetic band: Xq13

P2RY4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM069394: (about GC identifiers)

Start:	69,394,741 bp from pter
End:	69,396,379 bp from pter
Size:	1,639 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011669.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: P2RY4_HUMAN, P51582 (See protein sequence)

Recommended Name: P2Y purinoceptor 4

Size: 365 amino acids; 40963 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

2B6Q (3D)

Secondary accessions: Q4VBB7 Q4VBB8 Q502W2 Q5JT22

Post-translational modifications:

Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss

of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases¹

REFSEQ proteins: NP_002556.1

ENSEMBL proteins:

ENSP00000363643

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins and CompoZr ZFN and AQUA Peptides for P2RY4
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (P2Y4)
	Human Recombinant Proteins from Abnova (P2RY4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	8537336

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Antibodies for P2RY4:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of P2RY4
	Sigma-Aldrich Antibody Arrays and Antibodies for P2RY4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (P2Y4), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for P2RY4

Assays for P2RY4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P51582

ProtoNet protein and cluster: P51582

2 Blocks protein families:

IPB000018 P2Y4 purinoceptor signature

IPB002286 P2 purinoceptor signature

UniProtKB/Swiss-Prot: P2RY4_HUMAN, P51582

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RY4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RY4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002565

Applied Biosystems Silencer® siRNAs for P2RY4

Sigma-Aldrich siRNA and siRNA Panels for P2RY4

Sigma-Aldrich shRNA Panels and shRNA for P2RY4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for P2RY4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002565
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002565
untagged cDNA clone in CMV expression vector: NM_002565

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002565

UniProtKB/Swiss-Prot: P2RY4_HUMAN, P51582

Function: Receptor for UTP and UDP coupled to G-proteins that activate a

phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP

Genatlas biochemistry entry for P2RY4:

purinoceptor P2Y type 4,group 3,metabotropic,expressed in bone,osteoblastic and brain cell

lines,predominantly responding to UTP,G protein coupled receptor superfamily

2 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for P2ry4):

digestive/alimentary

lethality-prenatal/perinatal

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0045030	UTP-activated nucleotide receptor activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for P2RY4 (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling

GeneDecks P2RY4 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for P2RY4

5/9 Interacting proteins for P2RY4 (ENSP00000363643³) via UniProtKB, MINT, and/or STRING (see all 9 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
P2RX1	ENSP00000225538³	STRING (score=.807)
P2RX4	ENSP00000336607³	STRING (score=.807)
P2RX7	ENSP00000261826³	STRING (score=.806)
P2RX2	ENSP00000343339³	STRING (score=.804)
P2RX3	ENSP00000263314³	STRING (score=.801)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0007200	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	TAS	8537336
GO:0007204	elevation of cytosolic calcium ion concentration	TAS	8537335
GO:0030321	transepithelial chloride transport	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for P2RY4:

Antagonist Agonist

Compounds for P2RY4 available from Tocris Bioscience

Compound	Action	CAS number
UTPgammaS trisodium salt	Selective P2Y2/4 agonist
Suramin hexasodium salt	Non-selective P2 antagonist	[129-46-4]
2-Methylthioadenosine triphosphate tetrasodium salt	P2 purinergic agonist	[43170-89-4]
PPADS tetrasodium salt	P2 purinergic antagonist	[149017-66-3]

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10/15 Novoseek chemical compound relationships for P2RY4 gene (see all 15 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mrs2279	93.44	1	11959804 (1)
udpbetas	87.90	1	12737633 (1)
5-bromo-utp	85.73	1	17125260 (1)
mrs2179	85.52	1	12694404 (1)
2-methylthio-atp	81.08	2	11032896 (1)
atp	76.87	27	8700127 (3), 9690862 (2), 9415702 (1), 11032896 (1) (see all 20)
adp	73.51	2	18604596 (1)
uridine diphosphate	63.80	2	18604596 (1)
udpglucose	59.18	2	16475938 (1)
ribose	55.61	3	16359641 (2), 18514530 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RY4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RY4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002565

Sigma-Aldrich siRNA and siRNA Panels for P2RY4

Sigma-Aldrich shRNA Panels and shRNA for P2RY4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002565

REFSEQ mRNAs for P2RY4 gene:

NM_002565.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002565

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002565
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002565
                                 untagged cDNA clone in CMV expression vector: NM_002565

Additional cDNA sequence:

BC095503.1 BC096067.3 BC096068.1 BC096069.1 BC096070.1

1 DOTS entry:

DT.91905374

6 AceView cDNA sequences:

CN839938 NM_002565 CN839909 CN836358 CN843809 CN836272

highest scoring ESTs for P2RY4:

CN836272 CN836358 CN839909 CN839938 CN843809 BC095503 BC096067 BC096068 BC096069 BC096070

Unigene Cluster for P2RY4:

Pyrimidinergic receptor P2Y, G-protein coupled, 4

Hs.673854 [show with all ESTs]

Unigene Representative Sequence: NM_002565

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000374519

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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P2RY4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for P2RY4

¹ / ² / ³

2 probe-sets matching P2RY4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
221466_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002565	0.40	0.67	0.55	1
221466_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TGTTTCTCTA

SOURCE GeneReport for Unigene cluster: Hs.673854
UniProtKB/Swiss-Prot: P2RY4_HUMAN, P51582
Tissue specificity: Pancreas

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for P2RY4 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	P2RY4¹	--	pyrimidinergic receptor P2Y, G-protein coupled, 4	99.43(n) 99.32(a)	473656 XM_529029.2 XP_529029.2
cow (Bos taurus)	P2RY4¹	--	pyrimidinergic receptor P2Y, G-protein coupled, 4	85.3(n) 84.38(a)	514653 XM_592537.2 XP_592537.1
rat (Rattus norvegicus)	P2ry4¹	--	pyrimidinergic receptor P2Y, G-protein coupled, 4	84.03(n) 83.66(a)	63843 NM_031680.1 NP_113868.1
mouse (Mus musculus)	P2ry4^{1, 5}	X⁵	pyrimidinergic receptor P2Y, G-protein coupled, 4^{1, 5}	83.84(n)¹ 81.72(a)¹	57385¹ NM_020621.3¹ NP_065646.1¹ AJ277752⁵ AK076364⁵ (see all 8)
zebrafish (Danio rerio)	pr2y4l¹	--	pyrimidinergic receptor P2Y, G-protein coupled, 4-like	61.83(n) 61.83(a)	368435 NM_001004501.2 NP_001004501.1

About this table Species with no ortholog for P2RY4

ENSEMBL Gene Tree for P2RY4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for P2RY4 gene

P2RY1² P2RY6² P2RY2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/21 NCBI SNPs in P2RY4 are shown (see all 21 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 23)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1152187^1,2	A,C,F,H	69395667(+)	`CTTTGT/GTGCTG`	1	T/N	mis¹ ese³		11		EU EA WA NA	841
--	rs1152185^1,2	C,F,H	69397971(+)	`gttgtC/Tgtttt`	1	--	ng3¹		7		EU EA WA NA	562
	rs3829709^1,2	C,F,H	69395500(+)	`TGCAGA/CGCCTG`	1	S/A	mis¹		12		EU EA WA	1046
	rs1152188^1,2	C,H	69395628(+)	`CTTCAG/AGCCGA`	1	L/P	mis¹ ese³		4		EU EA WA	410
	rs12690240^1,2	H	69396575(+)	`CACAGC/ATATAT`	1	--	ng3¹		4		EU EA WA	412
	rs3829708^1,2	C,F,H	69395474(+)	`AGAGAG/TCGGAG`	1	R/R	syn¹		7		NA EU EA WA	535
	rs1152189^1,2	C	69395204(+)	`GAAGAA/GGCAGC`	1	A/A	syn¹ ese³ trp³		0	--	--	--	--
--	rs56217451^1,2	--	69395461(+)	`AGCTAC/TGGTGC`	1	I/V	mis¹		0	--	--	--	--
--	rs7887413^1,2	--	69398097(+)	`tcagaA/Cctctg`	1	--	ng3¹ tfbs³		0	--	--	--	--
--	rs72628859^1,2	--	69394303(+)	`ATAGAC/TGTGAG`	1	--	ng5¹		0	--	--	--	--

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HapMap Linkage Disequilibrium images for P2RY4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 300038

3 Novoseek disease relationships for P2RY4 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
astrocytoma	72.75	9	8700127 (1), 8913364 (1), 11711032 (1), 16607854 (1) (see all 9)
glioma	9.87	5	8700127 (1), 8913364 (1), 9131407 (1)
tumors	1.42	1	12880424 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/108 PubMed articles for P2RY4 gene (see all 108 ):

Cloning and functional expression of a human uridine nucleotide receptor. (PubMed id 8537336)^{1, 2, 3, 4} Communi D.... Boeynaems J.-M. (1995)
Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. Ser-333 and Ser-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor. (PubMed id 11114308)^{1, 3, 4} Brinson A.E. and Harden T.K. (2001)
Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. (PubMed id 8537335)^{1, 3, 4} Nguyen T.... O'Dowd B.F. (1995)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Molecular cloning and characterization of a novel orphan receptor (P2P) expressed in human pancreas that shows high structural homology to the P2U purinoceptor. (PubMed id 8617367)^{3, 4} Stam N.J.... Olijve W. (1996)
Distribution of P2Y receptor subtypes on haematopoietic cells. (PubMed id 9535005)^{1, 3} Jin J....Kunapuli S.P. (1998)
Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor. (PubMed id 8700127)^{1, 3} Nicholas R.A....Harden K. (1996)
The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells. (PubMed id 15649700)^{1, 3} Cavaliere F....Volonte C. (2005)
Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors. (PubMed id 12603858)^{1, 3} Burrell H.E....Sharpe G.R. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5030	HGNC: 8542	AceView: P2RY4	Ensembl:ENSG00000186912	euGenes: HUgn5030
ECgene: P2RY4	H-InvDB: P2RY4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for P2RY4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for P2RY4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for P2RY4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for P2RY4		Antibodies for P2RY4
	Explore super-pooled esiRNAs		Proteins for P2RY4
	Lentivirus-delivered shRNAs for P2RY4		Small molecules for P2RY4
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Search OriGene for P2RY4

Tocris compounds for P2RY4

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for P2RY4

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P2RY4 Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for P2RY4

Summaries
for P2RY4

Genomic Location
for P2RY4

Proteins
for P2RY4

Protein Domains/
Families
for P2RY4

Gene Function
for P2RY4

Pathways & Interactions
for P2RY4

Drugs & Compounds
for P2RY4

Transcripts
for P2RY4

Expression
for P2RY4

Orthologs
for P2RY4

Paralogs
for P2RY4

SNPs/Variants
for P2RY4

Disorders & Mutations
for P2RY4

Medical News
for P2RY4

Publications
for P2RY4

Search for P2RY4

Genome Databases showing P2RY4

Other Databases showing P2RY4

Specialized Databases showing P2RY4

Licensable Technologies
for P2RY4

Services
for P2RY4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

P2RY4 Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor P2RY4

Summariesfor P2RY4

Genomic Locationfor P2RY4

Proteinsfor P2RY4

Protein Domains/Familiesfor P2RY4

Gene Functionfor P2RY4

Pathways & Interactionsfor P2RY4

Drugs & Compoundsfor P2RY4

Transcriptsfor P2RY4

Expression for P2RY4

Orthologsfor P2RY4

Paralogsfor P2RY4

SNPs/Variantsfor P2RY4

Disorders & Mutationsfor P2RY4

Medical Newsfor P2RY4

Publicationsfor P2RY4

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Genome Databases showing P2RY4

Other Databases showing P2RY4

Specialized Databases showing P2RY4

Licensable Technologiesfor P2RY4

Servicesfor P2RY4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for P2RY4

Summaries
for P2RY4

Genomic Location
for P2RY4

Proteins
for P2RY4

Protein Domains/
Families
for P2RY4

Gene Function
for P2RY4

Pathways & Interactions
for P2RY4

Drugs & Compounds
for P2RY4

Transcripts
for P2RY4

Expression
for P2RY4

Orthologs
for P2RY4

Paralogs
for P2RY4

SNPs/Variants
for P2RY4

Disorders & Mutations
for P2RY4

Medical News
for P2RY4

Publications
for P2RY4

Licensable Technologies
for P2RY4

Services
for P2RY4