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P2RY4 Gene

protein-coding   GIFtS: 58
GCID: GC0XM069478

Pyrimidinergic Receptor P2Y, G-Protein Coupled, 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Pyrimidinergic Receptor P2Y, G-Protein Coupled, 41 2     P2P2 3
NRU2 3 5     UNR2 3
P2Y42 3 5     P2Y Purinoceptor 42
Uridine Nucleotide Receptor2 3     

External Ids:    HGNC: 85421   Entrez Gene: 50302   Ensembl: ENSG000001869127   OMIM: 3000385   UniProtKB: P515823   

Export aliases for P2RY4 gene to outside databases

Previous GC identifers: GC0XM065656 GC0XM066955 GC0XM067711 GC0XM068345 GC0XM069261 GC0XM069394 GC0XM063299


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for P2RY4 Gene:
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor
subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and
uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not
responsive to ADP. (provided by RefSeq, Jul 2008)

GeneCards Summary for P2RY4 Gene:
P2RY4 (pyrimidinergic receptor P2Y, G-protein coupled, 4) is a protein-coding gene. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity and UTP-activated nucleotide receptor activity. An important paralog of this gene is OXGR1.

UniProtKB/Swiss-Prot: P2RY4_HUMAN, P51582
Function: Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second
messenger system. Not activated by ATP or ADP

summary for P2RY4 Gene:
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine
nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13
and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10
receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4
receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13
and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades
including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They
have diverse physiological roles including regulation of platelet aggregation, muscle contraction,
neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the P2RY4 gene promoter:
         AP-2alpha isoform 3   AP-2alpha isoform 2   Tal-1beta   E47   Hand1   ARP-1   AP-2alpha isoform 4   AP-2alpha   ITF-2   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidP2RY4 promoter sequence
   Search Chromatin IP Primers for P2RY4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat P2RY4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13   Ensembl cytogenetic band:  Xq13.1   HGNC cytogenetic band: Xq13

P2RY4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P2RY4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XM069478:  view genomic region     (about GC identifiers)

Start:
69,478,016 bp from pter      End:
69,479,654 bp from pter
Size:
1,639 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: P2RY4_HUMAN, P51582 (See protein sequence)
Recommended Name: P2Y purinoceptor 4  
Size: 365 amino acids; 40963 Da
1 PDB 3D structure from and Proteopedia for P2RY4:
2B6Q (3D)    
Secondary accessions: Q4VBB7 Q4VBB8 Q502W2 Q5JT22

Explore the universe of human proteins at neXtProt for P2RY4: NX_P51582

Explore proteomics data for P2RY4 at MOPED

Post-translational modifications: 

  • Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface
    P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See P2RY4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002556.1  
    ENSEMBL proteins: 
     ENSP00000363643  
    Reactome Protein details: P51582

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    P2R: Purinergic receptors
    P2RY: GPCR / Class A : Purinergic receptors, P2Y

    IUPHAR Guide to PHARMACOLOGY protein family classification: P2Y4 receptor
    P2Y receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000018 P2Y4_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P51582

    ProtoNet protein and cluster: P51582

    2 Blocks protein domains:
    IPB000018 P2Y4 purinoceptor signature
    IPB002286 P2 purinoceptor signature


    UniProtKB/Swiss-Prot: P2RY4_HUMAN, P51582
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with P2RY4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P2RY4_HUMAN, P51582
    Function: Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second
    messenger system. Not activated by ATP or ADP

         Genatlas biochemistry entry for P2RY4:
    purinoceptor P2Y type 4,group 3,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly
    responding to UTP,G protein coupled receptor superfamily

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0005524ATP binding IEA--
    GO:0015065uridine nucleotide receptor activity TAS8537335
    GO:0045028G-protein coupled purinergic nucleotide receptor activity IEA--
    GO:0045030UTP-activated nucleotide receptor activity IEA--
         
    Find genes that share ontologies with P2RY4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for P2RY4:
     Increased gamma-H2AX phosphory 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for P2ry4):
     digestive/alimentary  mortality/aging 

    Find genes that share phenotypes with P2RY4           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for P2RY4: P2ry4tm1Lex P2ry4tm1Brob

       genOway: Develop your customized and physiologically relevant rodent model for P2RY4

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    hsa-miR-625
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P2RY4_HUMAN, P51582: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8537336
    GO:0016021integral component of membrane ----
    GO:0016323basolateral plasma membrane IEA--
    GO:0016324apical plasma membrane IEA--

    Find genes that share ontologies with P2RY4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for P2RY4 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Nucleotide-like (purinergic) receptors
    Nucleotide GPCRs0.00
    P2Y receptors0.00
    Nucleotide-like (purinergic) receptors
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Development Angiotensin activation of ERK
    Signal transduction IP3 signaling0.43
    5GPCR Pathway
    P2Y Receptor Signaling0.38


    Find genes that share SuperPaths with P2RY4           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for P2RY4
        P2Y Receptor Signaling

    1 GeneGo (Thomson Reuters) Pathway for P2RY4
        Signal transduction IP3 signaling

    2 BioSystems Pathways for P2RY4
        GPCRs, Class A Rhodopsin-like
    Nucleotide GPCRs

    2 Reactome Pathways for P2RY4
        P2Y receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for P2RY4):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY4: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for P2RY4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for P2RY4 (ENSP000003636434) via UniProtKB, MINT, STRING, and/or I2D (see all 145)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY6ENSP000003114054STRING: ENSP00000311405
    ADORA1ENSP000003085494STRING: ENSP00000308549
    ADRA2AENSP000002801554STRING: ENSP00000280155
    ADRA2BENSP000003872814STRING: ENSP00000387281
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway TAS8537336
    GO:0007204positive regulation of cytosolic calcium ion concentration TAS8537335
    GO:0030321transepithelial chloride transport IEA--

    Find genes that share ontologies with P2RY4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for P2RY4 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MRS 2365Highly potent and selective P2Y1 agonist[436847-09-5]
    alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist[7292-42-4]
    UTPgammaS trisodium saltSelective P2Y2/4 agonist[1266569-94-1]
    MRS 2500 tetraammonium saltExtremely potent and selective P2Y1 antagonist[630103-23-0]
    MRS 2179 tetrasodium saltSelective P2Y1 antagonist[101204-49-3]

    1 HMDB Compound for P2RY4    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for P2RY4 (P2Y4 receptor) (see all 12)    About this table
    LigandTypeActionAffinityPubmed IDs
    MRS4062
    AgonistFull agonist7.621528910
    MRS2927
    AgonistFull agonist7.2121528910
    N4-phenylethoxycytidine-5?a?-triphosphate
    AgonistFull agonist7.1421528910
    (N)methanocarba-UTP
    AgonistFull agonist7.111754592
    Up4U
    AgonistFull agonist6.416475938
    UTP
    AgonistFull agonist6.310779375
    ATP
    AntagonistAntagonist6.210779375
    Up4dC
    AgonistFull agonist6.112183642
    2-amino-uridine-5'-monophosphate
    AgonistPartial agonist5.321417463
    GTP
    AgonistPartial agonist5.210779375

    Selected Novoseek inferred chemical compound relationships for P2RY4 gene (see all 21)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mrs2279 92.2 1 11959804 (1)
    udpbetas 87.7 1 12737633 (1)
    mrs2179 86.4 1 12694404 (1)
    5-bromo-utp 85.5 1 17125260 (1)
    2-methylthio-atp 80.8 2 11032896 (1)
    bzatp 77.4 1 16373435 (1)
    atp 77.1 28 8700127 (3), 9690862 (2), 9415702 (1), 11032896 (1) (see all 21)
    ppads 76.2 4 8968535 (2), 12694404 (1), 11290369 (1)
    adp 73.9 2 18604596 (1)
    uridine diphosphate 68.4 2 18604596 (1)



    Find genes that share compounds with P2RY4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for P2RY4 gene: 
    NM_002565.3  

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000374519(uc004dxz.1)
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    6 AceView cDNA sequences:

    CN839938 NM_002565 CN839909 CN843809 CN836358 CN836272 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    P2RY4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTTCTCTA
    P2RY4 Expression
    About this image

    P2RY4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    P2RY4 Protein Expression

    UniProtKB/Swiss-Prot: P2RY4_HUMAN, P51582
    Tissue specificity: Pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY4: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for P2RY4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia P2ry41 , 5 pyrimidinergic receptor P2Y, G-protein coupled, 41, 5 83.67(n)1
    82.52(a)1
      X (43.72 cM)5
    573851  NM_020621.41  NP_065646.11 
     1005901545 
    chicken
    (Gallus gallus)
    Aves LOC1008576871 P2Y purinoceptor 4-like 66.56(n)
    62.58(a)
      100857687  XM_004940541.1  XP_004940598.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia p2ry4-prov2 purinergic receptor P2Y, G-protein coupled 4 75.58(n)    BC046837.1 
    zebrafish
    (Danio rerio)
    Actinopterygii pr2y4l1 pyrimidinergic receptor P2Y, G-protein coupled, 4-like 61.64(n)
    61.64(a)
      368435  XM_005173268.1  XP_005173325.1 


    ENSEMBL Gene Tree for P2RY4 (if available)
    TreeFam Gene Tree for P2RY4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for P2RY4 gene
    OXGR12  GPR172  P2RY12  P2RY62  GPR1742  LPAR62  LPAR52  CYSLTR12  
    GPR1832  LPAR42  CYSLTR22  P2RY22  SUCNR12  P2RY102  PTAFR2  
    Selected SIMAP similar genes for P2RY4 using alignment to 3 protein entries:     P2RY4_HUMAN (see all proteins) (see all similar genes):
    P2RY2    P2RY6    P2RY1    LPAR6    OXGR1    OPRM1
    LPAR4    CCR2    F2RL1    CCR5    CCR7    GPR17
    SSTR5    BDKRB1    CYSLTR2    GPR174    KPG_011    PTAFR

    Find genes that share paralogs with P2RY4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for P2RY4 (see all 107)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs125585911,2
    C,H--69485435(+) TCAATA/GCTAGA 1 -- ds50010--------
    rs726288591,2
    C--69485456(+) ATAGAT/CGTGAG 1 -- ds50011Minor allele frequency- C:0.00CSA 1
    rs1871660011,2
    --69485500(+) TCCTTC/TTGTTA 1 -- ds50010--------
    rs1492321561,2
    --69485597(+) CTAAGA/GTCCCC 1 -- ds50010--------
    rs1903533191,2
    --69485722(+) TCTTGA/GTAAGC 1 -- ds50010--------
    rs1820339141,2
    --69485883(+) CCTGAC/TCCACC 1 -- ds50010--------
    rs1852303961,2
    --69485966(+) AAAGAA/GGACTG 1 -- ut310--------
    rs1897372441,2
    --69486062(+) TAAAAA/GGAGTC 1 -- ut310--------
    rs1823319581,2
    --69486067(+) AGAGTA/CGGCAA 1 -- ut310--------
    rs2017343691,2
    C--69486252(+) TTCCCA/GTGTTA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for P2RY4 (69478016 - 69479654 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for P2RY4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519108CNV Loss19592680
    nsv525258CNV Gain19592680
    esv1584074OTHER Inversion17803354

    Human Gene Mutation Database (HGMD): P2RY4
    Locus Specific Mutation Databases (LSDB): P2RY4

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 300038    OMIM disorders: --


    Find genes that share disorders with P2RY4           About GenesLikeMe

    3 Novoseek inferred disease relationships for P2RY4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 72 9 8700127 (1), 8913364 (1), 11711032 (1), 16607854 (1) (see all 9)
    glioma 8.04 5 8700127 (1), 8913364 (1), 9131407 (1)
    tumors 1.45 1 12880424 (1)


    Export disorders for P2RY4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for P2RY4 gene, integrated from 10 sources (see all 118):
    (articles sorted by number of sources associating them with P2RY4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and functional expression of a human uridine nucleotide receptor. (PubMed id 8537336)1, 2, 3, 9 Communi D.... Boeynaems J.-M. (J. Biol. Chem. 1995)
    2. Differential regulation of the uridine nucleotide-activated P2Y4 and P2Y6 receptors. Ser-333 and Ser-334 in the carboxyl terminus are involved in agonist-dependent phosphorylation desensitization and internalization of the P2Y4 receptor. (PubMed id 11114308)1, 2, 9 Brinson A.E. and Harden T.K. (J. Biol. Chem. 2001)
    3. Cloning, expression, and chromosomal localization of the human uridine nucleotide receptor gene. (PubMed id 8537335)1, 2, 9 Nguyen T.... O'Dowd B.F. (J. Biol. Chem. 1995)
    4. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (Nature 2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Molecular cloning and characterization of a novel orphan receptor (P2P) expressed in human pancreas that shows high structural homology to the P2U purinoceptor. (PubMed id 8617367)1, 2 Stam N.J.... Olijve W. (FEBS Lett. 1996)
    7. Distribution of P2Y receptor subtypes on haematopoietic cells. (PubMed id 9535005)1, 9 Jin J....Kunapuli S.P. (Br. J. Pharmacol. 1998)
    8. Uridine nucleotide selectivity of three phospholipase C-activating P2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor. (PubMed id 8700127)1, 9 Nicholas R.A....Harden K. (Mol. Pharmacol. 1996)
    9. The metabotropic P2Y4 receptor participates in the commitment to differentiation and cell death of human neuroblastoma SH-SY5Y cells. (PubMed id 15649700)1, 9 Cavaliere F....VolontAc C. (Neurobiol. Dis. 2005)
    10. Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors. (PubMed id 12603858)1, 9 Burrell H.E....Sharpe G.R. (J. Invest. Dermatol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5030 HGNC: 8542 AceView: P2RY4 Ensembl:ENSG00000186912 euGenes: HUgn5030
    ECgene: P2RY4 Kegg: 5030 H-InvDB: P2RY4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for P2RY4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for P2RY4 gene:
    Search GeneIP for patents involving P2RY4

    GeneCards and IP:
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