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Aliases for P2RY2 Gene

Aliases for P2RY2 Gene

  • Purinergic Receptor P2Y, G-Protein Coupled, 2 2 3
  • P2Y2 3 4 6
  • P2U Purinoceptor 1 3 4
  • P2U Receptor 1 3 4
  • ATP Receptor 3 4
  • P2RU1 3 4
  • P2U1 3 4
  • P2U 3 6
  • Purinergic Receptor P2Y2 3
  • P2U Nucleotide Receptor 3
  • Purinergic Receptor 4
  • P2Y Purinoceptor 2 3
  • Purinoceptor P2Y2 3
  • P2Y2R 3
  • HP2U 3
  • P2UR 3

External Ids for P2RY2 Gene

Previous GeneCards Identifiers for P2RY2 Gene

  • GC11P075255
  • GC11P074469
  • GC11P073152
  • GC11P072655
  • GC11P072606
  • GC11P072929
  • GC11P069224

Summaries for P2RY2 Gene

Entrez Gene Summary for P2RY2 Gene

  • The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]

GeneCards Summary for P2RY2 Gene

P2RY2 (Purinergic Receptor P2Y, G-Protein Coupled, 2) is a Protein Coding gene. Diseases associated with P2RY2 include cystic fibrosis. Among its related pathways are GPCR Pathway and Signaling by GPCR. GO annotations related to this gene include receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is PTAFR.

UniProtKB/Swiss-Prot for P2RY2 Gene

  • Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP

Tocris Summary for P2RY2 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10 receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4 receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13 and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They have diverse physiological roles including regulation of platelet aggregation, muscle contraction, neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY2 Gene

Genomics for P2RY2 Gene

Regulatory Elements for P2RY2 Gene

Genomic Location for P2RY2 Gene

Start:
73,217,669 bp from pter
End:
73,242,427 bp from pter
Size:
24,759 bases
Orientation:
Plus strand

Genomic View for P2RY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for P2RY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY2 Gene

Proteins for P2RY2 Gene

  • Protein details for P2RY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41231-P2RY2_HUMAN
    Recommended name:
    P2Y purinoceptor 2
    Protein Accession:
    P41231
    Secondary Accessions:
    • B2R9W3
    • Q96EM8

    Protein attributes for P2RY2 Gene

    Size:
    377 amino acids
    Molecular mass:
    42273 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY2 Gene

neXtProt entry for P2RY2 Gene

Proteomics data for P2RY2 Gene at MOPED

Post-translational modifications for P2RY2 Gene

  • Ubiquitination at Lys227
  • Glycosylation at Asn9 and Asn13
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for P2RY2 Gene

Domains for P2RY2 Gene

Gene Families for P2RY2 Gene

HGNC:
  • P2RY :GPCR / Class A : Purinergic receptors, P2Y
  • P2R :Purinergic receptors
IUPHAR :

Protein Domains for P2RY2 Gene

Suggested Antigen Peptide Sequences for P2RY2 Gene

Graphical View of Domain Structure for InterPro Entry

P41231

UniProtKB/Swiss-Prot:

P2RY2_HUMAN :
  • P41231
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY2: view

Function for P2RY2 Gene

Molecular function for P2RY2 Gene

GENATLAS Biochemistry: purinoceptor P2Y type 2,group 3,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly responding to UTP,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP

Gene Ontology (GO) - Molecular Function for P2RY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 7779087
GO:0004930 G-protein coupled receptor activity --
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY2: view
genes like me logo Genes that share phenotypes with P2RY2: view

Animal Models for P2RY2 Gene

MGI Knock Outs for P2RY2:

miRNA for P2RY2 Gene

miRTarBase miRNAs that target P2RY2

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for P2RY2 Gene

Localization for P2RY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY2 Gene COMPARTMENTS Subcellular localization image for P2RY2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
endoplasmic reticulum 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for P2RY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8159738
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with P2RY2: view

Pathways for P2RY2 Gene

genes like me logo Genes that share pathways with P2RY2: view

Gene Ontology (GO) - Biological Process for P2RY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006873 cellular ion homeostasis TAS 8159738
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
GO:0042312 regulation of vasodilation IEA --
genes like me logo Genes that share ontologies with P2RY2: view

Compounds for P2RY2 Gene

(5) Tocris Compounds for P2RY2 Gene

Compound Action Cas Number
alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist [1343364-54-4]
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 [475193-31-8]
MRS 2179 tetrasodium salt Selective P2Y1 antagonist [1454889-37-2]
MRS 2365 Highly potent and selective P2Y1 agonist [436847-09-5]
MRS 2500 tetraammonium salt Extremely potent and selective P2Y1 antagonist [630103-23-0]

(1) HMDB Compounds for P2RY2 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Drugbank Compounds for P2RY2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Suramin
  • Bayer 205
145-63-1 target antagonist

(16) IUPHAR Ligand for P2RY2 Gene

Ligand Type Action Affinity Pubmed IDs
MRS2698 Agonist Full agonist 8.1
4-thio-UTP Agonist Full agonist 7.5
2-thioUTP Agonist Agonist 7.3
PSB1114 Agonist Full agonist 6.9
Up4U Agonist Full agonist 6.4
Up4dC Agonist Full agonist 6.1
Ap4A Agonist Full agonist 6.1
5BrUTP Agonist Partial agonist 6.1
AR-C118925XX Antagonist Antagonist 6
AR-C126313 Antagonist Antagonist 6
UTPgammaS Agonist Full agonist 5.8
MRS2768 Agonist Full agonist 5.7
UTP Agonist Full agonist 5.2
reactive blue-2 Antagonist Antagonist 5
ATP Activator None
suramin Activator None

(36) Novoseek inferred chemical compound relationships for P2RY2 Gene

Compound -log(P) Hits PubMed IDs
mrs2279 89.1 1
2-methylthio-atp 86.2 1
atpgammas 83 3
bzatp 82.9 1
utp.gamma.s 82.8 1
genes like me logo Genes that share compounds with P2RY2: view

Transcripts for P2RY2 Gene

Unigene Clusters for P2RY2 Gene

Purinergic receptor P2Y, G-protein coupled, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: -
SP3: -

Relevant External Links for P2RY2 Gene

GeneLoc Exon Structure for
P2RY2
ECgene alternative splicing isoforms for
P2RY2

Expression for P2RY2 Gene

mRNA expression in normal human tissues for P2RY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY2 Gene

This gene is overexpressed in Muscle - Skeletal (11.6), Esophagus - Mucosa (7.6), and Vagina (4.7).

SOURCE GeneReport for Unigene cluster for P2RY2 Gene Hs.339

mRNA Expression by UniProt/SwissProt for P2RY2 Gene

P41231-P2RY2_HUMAN
Tissue specificity: Spleen, testis, kidney, liver, lung, heart and brain
genes like me logo Genes that share expressions with P2RY2: view

No data available for Protein expression for P2RY2 Gene

Orthologs for P2RY2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY2 35
  • 99.56 (n)
  • 100 (a)
P2RY2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia P2RY2 35
  • 89.1 (n)
  • 86.7 (a)
P2RY2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY2 35
  • 89.48 (n)
  • 89.66 (a)
P2Y2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia P2ry2 35
  • 85.52 (n)
  • 90.62 (a)
P2ry2 16
P2ry2 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia P2RY2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia P2RY2 36
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2ry2 35
  • 85.38 (n)
  • 89.04 (a)
chicken
(Gallus gallus)
Aves P2RY2 35
  • 68.31 (n)
  • 70.16 (a)
P2RY2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75941 35
p2ry2 35
  • 64.36 (n)
  • 62.71 (a)
zebrafish
(Danio rerio)
Actinopterygii P2RY2 (1 of 3) 36
  • 48 (a)
OneToMany
P2RY2 (2 of 3) 36
  • 44 (a)
OneToMany
P2RY2 (3 of 3) 36
  • 45 (a)
OneToMany
Species with no ortholog for P2RY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY2 Gene

ENSEMBL:
Gene Tree for P2RY2 (if available)
TreeFam:
Gene Tree for P2RY2 (if available)

Paralogs for P2RY2 Gene

Selected SIMAP similar genes for P2RY2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for P2RY2 Gene

genes like me logo Genes that share paralogs with P2RY2: view

Variants for P2RY2 Gene

Sequence variations from dbSNP and Humsavar for P2RY2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs480305 -- 73,218,998(+) AATCT(C/G)GCAAA intron-variant, upstream-variant-2KB
rs498145 -- 73,220,822(+) CTCCT(A/G)CCCTG intron-variant
rs507126 -- 73,219,572(+) AGGAG(C/T)CTCCC intron-variant, upstream-variant-2KB
rs508859 -- 73,219,761(+) CCCTG(A/G)CCTGT intron-variant, upstream-variant-2KB
rs557451 -- 73,216,074(-) TTTGC(C/T)TTTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for P2RY2 Gene

Variant ID Type Subtype PubMed ID
nsv832208 CNV Gain 17160897
nsv518659 CNV Gain 19592680

Relevant External Links for P2RY2 Gene

HapMap Linkage Disequilibrium report
P2RY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY2 Gene

Disorders for P2RY2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for P2RY2 Gene including...

Search for P2RY2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for P2RY2 Gene

(8) Novoseek inferred disease relationships for P2RY2 Gene

Disease -log(P) Hits PubMed IDs
astrocytoma 66.1 8
dry eye syndromes 42.9 1
cystic fibrosis 39 3
glioma 13 4
tumors 3.63 3

Relevant External Links for P2RY2

Genetic Association Database (GAD)
P2RY2
Human Genome Epidemiology (HuGE) Navigator
P2RY2
genes like me logo Genes that share disorders with P2RY2: view

No data available for UniProtKB/Swiss-Prot for P2RY2 Gene

Publications for P2RY2 Gene

  1. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. (PMID: 8159738) Parr C.E. … Turner J.T. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 3 4 23
  2. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. (PMID: 7809171) Parr C.E. … Turner J.T. (Proc. Natl. Acad. Sci. U.S.A. 1994) 3 4 23
  3. Purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene is associated with cerebral infarction in Japanese subjects. (PMID: 19763137) Wang Z. … Hinohara S. (Hypertens. Res. 2009) 3 23 48
  4. Association of the purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene with myocardial infarction in Japanese men. (PMID: 19797825) Wang Z.X. … Hinohara S. (Circ. J. 2009) 3 23 48
  5. ATP modulates transcription factors through P2Y2 and P2Y4 receptors via PKC/MAPKs and PKC/Src pathways in MCF-7 cells. (PMID: 19900397) Scodelaro Bilbao P. … Santillan G. (Arch. Biochem. Biophys. 2010) 3 23

Products for P2RY2 Gene

Sources for P2RY2 Gene

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