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Aliases for P2RY2 Gene

Aliases for P2RY2 Gene

  • Purinergic Receptor P2Y2 2 3 5
  • Purinergic Receptor P2Y, G-Protein Coupled, 2 2 3
  • P2U Purinoceptor 1 3 4
  • P2U Receptor 1 3 4
  • ATP Receptor 3 4
  • P2RU1 3 4
  • P2U1 3 4
  • P2Y2 3 4
  • P2U Nucleotide Receptor 3
  • Purinergic Receptor 4
  • P2Y Purinoceptor 2 3
  • Purinoceptor P2Y2 3
  • P2Y2R 3
  • HP2U 3
  • P2UR 3
  • P2U 3

External Ids for P2RY2 Gene

Previous GeneCards Identifiers for P2RY2 Gene

  • GC11P075255
  • GC11P074469
  • GC11P073152
  • GC11P072655
  • GC11P072606
  • GC11P072929
  • GC11P069224

Summaries for P2RY2 Gene

Entrez Gene Summary for P2RY2 Gene

  • The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]

GeneCards Summary for P2RY2 Gene

P2RY2 (Purinergic Receptor P2Y2) is a Protein Coding gene. Diseases associated with P2RY2 include Dry Eye Syndrome and Lacrimal Apparatus Disease. Among its related pathways are Nucleotide-like (purinergic) receptors and GPCR Pathway. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY4.

UniProtKB/Swiss-Prot for P2RY2 Gene

  • Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

Tocris Summary for P2RY2 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY2 Gene

Additional gene information for P2RY2 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY2 Gene

Genomics for P2RY2 Gene

Regulatory Elements for P2RY2 Gene

Enhancers for P2RY2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H073192 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.7 -21.9 -21946 4 TBP PKNOX1 TBL1XR1 NFIB SREBF2 ZNF133 SIN3A RAD21 BATF ZBTB7B ENSG00000215841 P2RY2 ARHGEF17 RELT ENSG00000260401 GC11M073182
GH11H073268 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +55.6 55599 7 FOXA2 ARID4B SIN3A SCRT2 FOS RCOR1 IKZF2 SMARCA5 SMARCC1 ELF1 RELT FCHSD2 ENSG00000215841 P2RY2 ARHGEF17 P2RY6
GH11H073187 1.3 Ensembl ENCODE dbSUPER 12.5 -27.2 -27180 2 FOXA2 MAX EBF1 GATA3 POLR2A RERE EED NR2F6 RUNX3 CREM ENSG00000215841 P2RY2 ENSG00000260401 GC11M073182
GH11H073239 1.1 Ensembl ENCODE dbSUPER 12.1 +23.8 23841 1 SMARCA5 POLR2A SREBF2 USF2 CEBPB NFXL1 NR2F2 P2RY6 P2RY2 ENSG00000215841 ARAP1 ARAP1-AS1 GC11P073239 OR8R1P
GH11H073276 0.5 dbSUPER 11.5 +60.9 60944 1 ZC3H11A CEBPB ZNF623 ZNF781 ZNF518A ENSG00000215841 P2RY2 ARHGEF17 RELT FCHSD2 P2RY6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around P2RY2 on UCSC Golden Path with GeneCards custom track

Promoters for P2RY2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000041835 1952 801 ARID4B SIN3A ZBTB7B GLIS2 SP3 SP5 MXD4 REST MXD3 HNF4A

Genomic Location for P2RY2 Gene

Chromosome:
11
Start:
73,216,448 bp from pter
End:
73,242,427 bp from pter
Size:
25,980 bases
Orientation:
Plus strand

Genomic View for P2RY2 Gene

Genes around P2RY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY2 Gene

Proteins for P2RY2 Gene

  • Protein details for P2RY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41231-P2RY2_HUMAN
    Recommended name:
    P2Y purinoceptor 2
    Protein Accession:
    P41231
    Secondary Accessions:
    • B2R9W3
    • Q96EM8

    Protein attributes for P2RY2 Gene

    Size:
    377 amino acids
    Molecular mass:
    42273 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY2 Gene

neXtProt entry for P2RY2 Gene

Post-translational modifications for P2RY2 Gene

  • Ubiquitination at posLast=227227
  • Glycosylation at Asn9 and posLast=1313
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for P2RY2 Gene

Domains & Families for P2RY2 Gene

Gene Families for P2RY2 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • FDA approved drug targets
  • G-protein coupled receptors
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for P2RY2 Gene

Graphical View of Domain Structure for InterPro Entry

P41231

UniProtKB/Swiss-Prot:

P2RY2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY2: view

Function for P2RY2 Gene

Molecular function for P2RY2 Gene

GENATLAS Biochemistry:
purinoceptor P2Y type 2,group 3,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly responding to UTP,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP.

Phenotypes From GWAS Catalog for P2RY2 Gene

Gene Ontology (GO) - Molecular Function for P2RY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 7779087
GO:0004930 G-protein coupled receptor activity IEA --
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY2: view
genes like me logo Genes that share phenotypes with P2RY2: view

Animal Models for P2RY2 Gene

MGI Knock Outs for P2RY2:

Animal Model Products

  • Taconic Biosciences Mouse Models for P2RY2

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for P2RY2
  • Applied Biological Materials Clones for P2RY2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RY2 Gene

Localization for P2RY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 3
endoplasmic reticulum 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for P2RY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8159738
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with P2RY2: view

Pathways & Interactions for P2RY2 Gene

genes like me logo Genes that share pathways with P2RY2: view

Gene Ontology (GO) - Biological Process for P2RY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006873 cellular ion homeostasis TAS 8159738
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with P2RY2: view

No data available for SIGNOR curated interactions for P2RY2 Gene

Drugs & Compounds for P2RY2 Gene

(56) Drugs for P2RY2 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Suramin Approved Pharma Antagonist, antagonist, Target 18
Prasugrel Approved Pharma ADP receptor inhibitor 0
Uridine triphosphate Experimental Pharma 0
Denufosol Investigational Pharma Target 0
INS 316 Investigational Pharma Target 0

(26) Additional Compounds for P2RY2 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Up<sub>4</sub>dC
Full agonist, Agonist
Up<sub>4</sub>U
Full agonist, Agonist
UTP
Full agonist, Agonist
UTPgammaS
Full agonist, Agonist
AR-C 118925XX
216657-60-2

(5) Tocris Compounds for P2RY2 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
AR-C 118925XX Selective, competitive P2Y2 receptor antagonist 216657-60-2
MRS 2500 tetraammonium salt Extremely potent and selective P2Y1 antagonist 630103-23-0
PPTN hydrochloride High affinity and selective P2Y14 antagonist
SAR 216471 hydrochloride Potent P2Y12 antagonist; orally available 1279829-64-9

(22) ApexBio Compounds for P2RY2 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt 475193-31-8
2-ThioUTP tetrasodium salt 1343364-70-4
DMNPE-caged ATP diammonium salt
MRS 2179 tetrasodium salt 1454889-37-2
MRS 2211
MRS 2279 367909-40-8
MRS 2365 436847-09-5
MRS 2500 tetraammonium salt 630103-23-0
MRS 2690 15039-58-4
MRS 2693 trisodium salt 1448858-83-0
MRS 2768 tetrasodium salt 1047980-83-5
MRS 2957 triethylammonium salt 1228271-30-4
NF 340 202982-98-7
NF 546 1006028-37-0
PIT 56583-49-4
Prasugrel ADP receptor inhibitor 150322-43-3
Prasugrel Maleic acid 389574-20-3
PSB 0474 917567-60-3
PSB 1114 P2Y2 receptor agonist
UDP disodium salt 27821-45-0
UTPγS trisodium salt 1266569-94-1
α,β-Methyleneadenosine 5'-triphosphate trisodium salt 1343364-54-4
genes like me logo Genes that share compounds with P2RY2: view

Drug Products

Transcripts for P2RY2 Gene

Unigene Clusters for P2RY2 Gene

Purinergic receptor P2Y, G-protein coupled, 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for P2RY2
  • Applied Biological Materials Clones for P2RY2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: -
SP3: -

Relevant External Links for P2RY2 Gene

GeneLoc Exon Structure for
P2RY2
ECgene alternative splicing isoforms for
P2RY2

Expression for P2RY2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for P2RY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY2 Gene

This gene is overexpressed in Muscle - Skeletal (x11.6), Esophagus - Mucosa (x7.6), and Vagina (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of P2RY2 Gene:

P2RY2

SOURCE GeneReport for Unigene cluster for P2RY2 Gene:

Hs.339

mRNA Expression by UniProt/SwissProt for P2RY2 Gene:

P41231-P2RY2_HUMAN
Tissue specificity: Spleen, testis, kidney, liver, lung, heart and brain.

Evidence on tissue expression from TISSUES for P2RY2 Gene

  • Lung(4.4)
  • Blood(4.3)
  • Kidney(4.3)
  • Muscle(2.7)
  • Heart(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with P2RY2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RY2 Gene

Orthologs for P2RY2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY2 33 34
  • 99.56 (n)
dog
(Canis familiaris)
Mammalia P2RY2 33
  • 89.48 (n)
P2Y2 34
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia P2RY2 33 34
  • 89.1 (n)
mouse
(Mus musculus)
Mammalia P2ry2 33 16 34
  • 85.52 (n)
rat
(Rattus norvegicus)
Mammalia P2ry2 33
  • 85.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia P2RY2 34
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia P2RY2 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves P2RY2 33 34
  • 68.31 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry2 33
  • 64.36 (n)
MGC75941 33
zebrafish
(Danio rerio)
Actinopterygii P2RY2 (1 of 3) 34
  • 48 (a)
OneToMany
P2RY2 (3 of 3) 34
  • 45 (a)
OneToMany
P2RY2 (2 of 3) 34
  • 44 (a)
OneToMany
Species where no ortholog for P2RY2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY2 Gene

ENSEMBL:
Gene Tree for P2RY2 (if available)
TreeFam:
Gene Tree for P2RY2 (if available)

Paralogs for P2RY2 Gene

Paralogs for P2RY2 Gene

(18) SIMAP similar genes for P2RY2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for P2RY2 Gene

genes like me logo Genes that share paralogs with P2RY2: view

Variants for P2RY2 Gene

Sequence variations from dbSNP and Humsavar for P2RY2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000014606 -- 73,214,218(+) AATTC(C/T)TAATT intron-variant
rs1000041476 -- 73,211,984(+) ATTGT(C/T)ATAAT intron-variant
rs1000053902 -- 73,246,996(+) TTTCA(A/G/T)CTGCG downstream-variant-500B
rs1000091054 -- 73,246,025(+) TTGGA(A/G)GGTCT intron-variant
rs1000241729 -- 73,212,567(+) TAAAC(G/T)ATAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for P2RY2 Gene

Variant ID Type Subtype PubMed ID
esv3429235 CNV insertion 20981092
esv3626812 CNV gain 21293372
esv3626813 CNV loss 21293372
nsv1038032 CNV gain 25217958
nsv476705 CNV novel sequence insertion 20440878
nsv518659 CNV gain 19592680
nsv832208 CNV gain 17160897

Variation tolerance for P2RY2 Gene

Residual Variation Intolerance Score: 54% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.69; 82.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RY2 Gene

Human Gene Mutation Database (HGMD)
P2RY2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
P2RY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY2 Gene

Disorders for P2RY2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for P2RY2 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
dry eye syndrome
  • xerophthalmia
lacrimal apparatus disease
  • lacrimal apparatus diseases
deafness, autosomal recessive 63
  • autosomal recessive nonsyndromic deafness 63
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
- elite association - COSMIC cancer census association via MalaCards
Search P2RY2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for P2RY2

Genetic Association Database (GAD)
P2RY2
Human Genome Epidemiology (HuGE) Navigator
P2RY2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
P2RY2
genes like me logo Genes that share disorders with P2RY2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RY2 Gene

Publications for P2RY2 Gene

  1. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. (PMID: 8159738) Parr CE … Turner JT (Proceedings of the National Academy of Sciences of the United States of America 1994) 2 3 4 22 60
  2. Association of the purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene with myocardial infarction in Japanese men. (PMID: 19797825) Wang ZX … Hinohara S (Circulation journal : official journal of the Japanese Circulation Society 2009) 3 22 45 60
  3. Purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene is associated with cerebral infarction in Japanese subjects. (PMID: 19763137) Wang Z … Hinohara S (Hypertension research : official journal of the Japanese Society of Hypertension 2009) 3 22 45 60
  4. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. (PMID: 7809171) Parr CE … Turner JT (Proceedings of the National Academy of Sciences of the United States of America 1994) 3 4 22 60
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60

Products for P2RY2 Gene

  • Addgene plasmids for P2RY2

Sources for P2RY2 Gene

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