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P2RY2 Gene

protein-coding   GIFtS: 71
GCID: GC11P072929

Purinergic Receptor P2Y, G-Protein Coupled, 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Purinergic Receptor P2Y, G-Protein Coupled, 21 2     HP2U2
P2Y22 3 5     P2UR2
P2RU12 3     P2Y2R2
P2U12 3     P2U Nucleotide Receptor2
ATP Receptor2 3     P2Y Purinoceptor 22
P2U Purinoceptor 12 3     Purinergic Receptor P2Y22
P2U Receptor 12 3     Purinoceptor P2Y22
P2U2 5     Purinergic Receptor3

External Ids:    HGNC: 85411   Entrez Gene: 50292   Ensembl: ENSG000001755917   OMIM: 6000415   UniProtKB: P412313   

Export aliases for P2RY2 gene to outside databases

Previous GC identifers: GC11P075255 GC11P074469 GC11P073152 GC11P072655 GC11P072606 GC11P069224


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for P2RY2 Gene:
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides
and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several
receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine
and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to
be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation,
apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this
gene. (provided by RefSeq, Mar 2013)

GeneCards Summary for P2RY2 Gene:
P2RY2 (purinergic receptor P2Y, G-protein coupled, 2) is a protein-coding gene. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity and receptor activity. An important paralog of this gene is OXGR1.

UniProtKB/Swiss-Prot: P2RY2_HUMAN, P41231
Function: Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second
messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP

summary for P2RY2 Gene:
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine
nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13
and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10
receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4
receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13
and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades
including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They
have diverse physiological roles including regulation of platelet aggregation, muscle contraction,
neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the P2RY2 gene promoter:
         PPAR-gamma1   c-Myb   AP-4   PPAR-gamma2   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidP2RY2 promoter sequence
   Search Chromatin IP Primers for P2RY2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat P2RY2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.5-q14.1   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.5-q14.1

P2RY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P2RY2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P072929:  view genomic region     (about GC identifiers)

Start:
72,929,343 bp from pter      End:
72,947,397 bp from pter
Size:
18,055 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: P2RY2_HUMAN, P41231 (See protein sequence)
Recommended Name: P2Y purinoceptor 2  
Size: 377 amino acids; 42273 Da
1 PDB 3D structure from and Proteopedia for P2RY2:
1Z8E (3D)    
Secondary accessions: B2R9W3 Q96EM8

Explore the universe of human proteins at neXtProt for P2RY2: NX_P41231

Explore proteomics data for P2RY2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys227
  • Glycosylation2 at Asn9, Asn13
  • Modification sites at PhosphoSitePlus

  • See P2RY2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_002555.3  NP_788085.2  NP_788086.2  

    ENSEMBL proteins: 
     ENSP00000377222   ENSP00000310305   ENSP00000377221  
    Reactome Protein details: P41231

    P2RY2 Human Recombinant Protein Products:

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    Novus Biologicals P2RY2 Lysates
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for P2RY2

     
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    antibodies-online proteins for P2RY2 (4 products) 

     
    antibodies-online peptides for P2RY2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    P2R: Purinergic receptors
    P2RY: GPCR / Class A : Purinergic receptors, P2Y

    IUPHAR Guide to PHARMACOLOGY protein family classification: P2Y2 receptor
    P2Y receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000356 P2Y2_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P41231

    ProtoNet protein and cluster: P41231

    2 Blocks protein domains:
    IPB000356 P2Y2 purinoceptor signature
    IPB002286 P2 purinoceptor signature


    UniProtKB/Swiss-Prot: P2RY2_HUMAN, P41231
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with P2RY2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P2RY2_HUMAN, P41231
    Function: Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second
    messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP

         Genatlas biochemistry entry for P2RY2:
    purinoceptor P2Y type 2,group 3,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly
    responding to UTP,G protein coupled receptor superfamily

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS7779087
    GO:0004930G-protein coupled receptor activity ----
    GO:0045028G-protein coupled purinergic nucleotide receptor activity IEA--
         
    Find genes that share ontologies with P2RY2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for P2RY2:
     Decreased viability of wild-ty 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for P2ry2):
     cellular  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with P2RY2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out P2ry2tm1Bhk for P2RY2

       genOway: Develop your customized and physiologically relevant rodent model for P2RY2

    miRNA
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    miRTarBase miRNAs that target P2RY2:
    hsa-mir-335-5p (MIRT018463)

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    8 qRT-PCR Assays for microRNAs that regulate P2RY2:
    hsa-miR-140-3p hsa-miR-136 hsa-miR-634 hsa-miR-631 hsa-miR-330-5p hsa-miR-326 hsa-miR-3143 hsa-miR-3661
    SwitchGear 3'UTR luciferase reporter plasmidP2RY2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P2RY2_HUMAN, P41231: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular3
    endoplasmic reticulum2
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8159738
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with P2RY2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for P2RY2 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Nucleotide-like (purinergic) receptors
    Nucleotide GPCRs0.00
    P2Y receptors0.00
    Nucleotide-like (purinergic) receptors
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Development Angiotensin activation of ERK
    Signal transduction IP3 signaling0.43


    Find genes that share SuperPaths with P2RY2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for P2RY2
        P2Y Receptor Signaling

    2 GeneGo (Thomson Reuters) Pathways for P2RY2
        CFTR-dependent regulation of ion channels in Airway Epithelium (norm and CF)
    Signal transduction IP3 signaling

    2 BioSystems Pathways for P2RY2
        GPCRs, Class A Rhodopsin-like
    Nucleotide GPCRs

    2 Reactome Pathways for P2RY2
        P2Y receptors
    G alpha (q) signalling events


    2 Kegg Pathways  (Kegg details for P2RY2):
        Neuroactive ligand-receptor interaction
    Inflammatory mediator regulation of TRP channels

        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY2: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for P2RY2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for P2RY2 (P412312, 3 ENSP000003103054) via UniProtKB, MINT, STRING, and/or I2D (see all 131)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147452, 3, ENSP000002626134MINT-1796602 I2D: score=1 STRING: ENSP00000262613
    ITGAVP067563, ENSP000002610234I2D: score=1 STRING: ENSP00000261023
    ITGB5P180843, ENSP000002961814I2D: score=1 STRING: ENSP00000296181
    KDRP359683, ENSP000002639234I2D: score=1 STRING: ENSP00000263923
    SRCP129313, ENSP000003509414I2D: score=1 STRING: ENSP00000350941
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006873cellular ion homeostasis TAS8159738
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway IEA--
    GO:0042312regulation of vasodilation IEA--
    GO:0070257positive regulation of mucus secretion IEA--

    Find genes that share ontologies with P2RY2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for P2RY2 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MRS 2365Highly potent and selective P2Y1 agonist[436847-09-5]
    alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist[7292-42-4]
    UTPgammaS trisodium saltSelective P2Y2/4 agonist[1266569-94-1]
    MRS 2500 tetraammonium saltExtremely potent and selective P2Y1 antagonist[630103-23-0]
    MRS 2179 tetrasodium saltSelective P2Y1 antagonist[101204-49-3]

    1 HMDB Compound for P2RY2    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 DrugBank Compound for P2RY2    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    SuraminBayer 205 (see all 6)145-63-1targetantagonist8762097 9112981 9647463 11132624 16388598

    Selected IUPHAR Ligands for P2RY2 (P2Y2 receptor) (see all 16)    About this table
    LigandTypeActionAffinityPubmed IDs
    UTP
    AgonistFull agonist8.18564228 11754592
    MRS2698
    AgonistFull agonist8.117302398
    4-thio-UTP
    AgonistFull agonist7.516475938
    2-thioUTP
    AgonistAgonist7.317125260
    ATP
    AgonistFull agonist7.18564228 11754592
    Up4U
    AgonistFull agonist711206448
    PSB1114
    AgonistFull agonist6.921417463
    Up4dC
    AgonistFull agonist6.712183642
    Ap4A
    AgonistFull agonist6.11393282 11711032
    AR-C118925XX
    AntagonistAntagonist615231488

    Selected Novoseek inferred chemical compound relationships for P2RY2 gene (see all 36)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mrs2279 89.1 1 11959804 (1)
    2-methylthio-atp 86.2 2 11032896 (1)
    atpgammas 83 4 14710912 (2), 10869373 (1)
    bzatp 82.9 1 16373435 (1)
    utp.gamma.s 82.8 2 10869373 (1)
    ppads 82.7 1 10540220 (1)
    atp 81.1 56 10540220 (3), 8557776 (2), 17170310 (2), 8723843 (2) (see all 42)
    adenosine 5'-o-(3-thiotriphosphate) 79.2 2 10869373 (1), 8058061 (1)
    datpalphas 79.2 1 9154346 (1)
    adp 77.3 8 8750911 (1), 9108793 (1), 8058061 (1), 12691958 (1) (see all 6)



    Find genes that share compounds with P2RY2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for P2RY2 gene (3 alternative transcripts): 
    NM_002564.3  NM_176071.2  NM_176072.2  

    Unigene Cluster for P2RY2:

    Purinergic receptor P2Y, G-protein coupled, 2
    Hs.339  [show with all ESTs]
    Unigene Representative Sequence: NM_176072
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393597 ENST00000311131(uc001otk.3 uc001otj.3 uc001otl.3)
    ENST00000393596
    miRNA
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat P2RY2
      QuantiTect SYBR Green Assays in human, mouse, rat P2RY2
      QuantiFast Probe-based Assays in human, mouse, rat P2RY2

    Additional mRNA sequence: 

    AK313942.1 AY136753.1 BC012104.1 BC028135.1 FJ599699.1 FJ599700.1 U07225.1 

    3 DOTS entries:

    DT.208493  DT.97806314  DT.95366177 

    Selected AceView cDNA sequences (see all 35):

    AI680372 BQ083469 NM_176072 NM_176071 BE741687 BC028135 BM769746 CA314211 
    NM_002564 U07225 BM851506 BI907874 AY136753 BC012104 F22708 BX102461 
    BF791674 BF988939 BM826753 CF147799 AI743321 AI590582 AI830220 R70505 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for P2RY2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
    SP1:        -           -                     
    SP2:        -                                 
    SP3:                    -                     


    ECgene alternative splicing isoforms for P2RY2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    P2RY2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTAGGAGC
    P2RY2 Expression
    About this image


    P2RY2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Bone (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Cartilage (Muscoskeletal System)
             Chondrocytes Zeugopod Epiphyseal End
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Placenta (Extraembryonic Tissues)
    P2RY2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    P2RY2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.339

    UniProtKB/Swiss-Prot: P2RY2_HUMAN, P41231
    Tissue specificity: Spleen, testis, kidney, liver, lung, heart and brain

        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY2: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for P2RY2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia P2ry21 , 5 purinergic receptor P2Y, G-protein coupled 21, 5 85.52(n)1
    90.62(a)1
      7 (54.47 cM)5
    184421  NM_008773.31  NP_032799.21 
     1009965725 
    chicken
    (Gallus gallus)
    Aves P2RY21 purinergic receptor P2Y, G-protein coupled, 2 68.31(n)
    70.16(a)
      428108  XM_004938999.1  XP_004939056.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia MGC759412 hypothetical protein MGC75941 74.5(n)    BC061378.1 
    zebrafish
    (Danio rerio)
    Actinopterygii P2RY2 (1 of 3)6
    P2RY2 (3 of 3)6
    (see all 3)
    purinergic receptor P2Y, G-protein coupled, 2
    (see all 3)
    48(a)
    45(a)
    (see all 3)
    1 ↔ many
    1 ↔ many
    (see all 3)
    18(2060719-2070819) ENSDARG00000063545
    18(2091354-2092343) ENSDARG00000075370


    ENSEMBL Gene Tree for P2RY2 (if available)
    TreeFam Gene Tree for P2RY2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for P2RY2 gene
    OXGR12  P2RY42  GPR172  P2RY12  P2RY62  GPR1742  LPAR62  LPAR52  
    CYSLTR12  GPR1832  LPAR42  CYSLTR22  SUCNR12  P2RY102  PTAFR2  
    18 SIMAP similar genes for P2RY2 using alignment to 3 protein entries:     P2RY2_HUMAN (see all proteins):
    P2RY4    CMKLR1    CYSLTR2    KPG_011    LPAR6    OXGR1
    P2RY1    P2RY6    GPR17    SSTR5    LPAR4    SSTR2
    CYSLTR1    GPR174    KPG_007    GPR183    SUCNR1    P2RY10

    Find genes that share paralogs with P2RY2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for P2RY2
    PGOHUM00000250268


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for P2RY2 (see all 549)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1479094451,2
    --72927447(+) GCCTGA/GTCAAC 2 -- us2k10--------
    rs114445191,2
    C--72927473(+) AAAAA-/ATTTAC 2 -- us2k1 tfbs30--------
    rs1827413621,2
    --72927491(+) AATTAA/GCCCGG 2 -- us2k10--------
    rs1878552971,2
    --72927752(+) CTAAAC/GCCAAG 3 -- us2k10--------
    rs1400147381,2
    --72927899(+) GGGCAG/TAGCCC 3 -- us2k10--------
    rs792638651,2
    C--72927931(+) TTGCCC/TGCTGA 3 -- us2k10--------
    rs679923411,2
    C,F--72927934(+) CCCGCA/G/TGAAGG 3 -- us2k14WA NA 242
    rs1454397091,2
    --72928020(+) AAGGTC/TTGAAG 3 -- us2k10--------
    rs749411401,2
    F--72928248(+) CGGCTC/TAGCCA 3 -- us2k11Minor allele frequency- T:0.02NA 120
    rs774545091,2
    C,F--72928373(+) AGGCCC/TGGGGC 3 -- us2k11Minor allele frequency- T:0.03WA 118

    HapMap Linkage Disequilibrium report for P2RY2 (72929343 - 72947397 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for P2RY2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv518659CNV Gain19592680
    nsv832208CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing P2RY2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600041    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for P2RY2:
    Cystic fibrosis     Dry eye syndrome

    Find genes that share disorders with P2RY2           About GenesLikeMe

    8 Novoseek inferred disease relationships for P2RY2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 66.1 8 8913364 (1), 11711032 (1), 15778502 (1), 16607854 (1) (see all 8)
    dry eye syndromes 42.9 1 12369950 (1)
    cystic fibrosis 39 3 8159738 (1), 12369950 (1), 7809171 (1)
    glioma 13 4 11159687 (2), 8913364 (1), 8752584 (1)
    tumors 3.63 3 16920697 (2), 12880424 (1)
    cancer 0.889 1 17382903 (1)
    inflammation 0 4 15841322 (1), 17599409 (1), 19734210 (1), 16920697 (1)
    atherosclerosis 0 4 19797825 (1), 15841322 (1), 19763137 (1)

    Genetic Association Database (GAD): P2RY2
    Human Genome Epidemiology (HuGE) Navigator: P2RY2 (10 documents)

    Export disorders for P2RY2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for P2RY2 gene, integrated from 10 sources (see all 254):
    (articles sorted by number of sources associating them with P2RY2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. (PubMed id 8159738)1, 2, 3, 9 Parr C.E.... Turner J.T. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    2. Purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene is associated with cerebral infarction in Japanese subjects. (PubMed id 19763137)1, 4, 9 Wang Z....Hinohara S. (Hypertens. Res. 2009)
    3. Association of the purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene with myocardial infarction in Japanese men. (PubMed id 19797825)1, 4, 9 Wang Z.X....Hinohara S. (Circ. J. 2009)
    4. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. (PubMed id 7809171)1, 2, 9 Parr C.E.... Turner J.T. (Proc. Natl. Acad. Sci. U.S.A. 1994)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    7. The purinergic receptor P2Y, G-protein coupled, 2 (P2RY2) gene associated with essential hypertension in Japanese men. (PubMed id 19710694)1, 4 Wang Z....Ma Y. (J Hum Hypertens 2010)
    8. P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx. (PubMed id 16495779)1, 4 BA1scher R....Insel P.A. (Pharmacogenet. Genomics 2006)
    9. Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (PubMed id 17137217)1, 4 Kokubo Y....Miyata T. (Hypertens. Res. 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5029 HGNC: 8541 AceView: P2RY2 Ensembl:ENSG00000175591 euGenes: HUgn5029
    ECgene: P2RY2 Kegg: 5029 H-InvDB: P2RY2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for P2RY2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for P2RY2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for P2RY2 gene:
    Search GeneIP for patents involving P2RY2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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