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Aliases for P2RY2 Gene

Aliases for P2RY2 Gene

  • Purinergic Receptor P2Y, G-Protein Coupled, 2 2 3
  • P2U Purinoceptor 1 3 4
  • P2U Receptor 1 3 4
  • ATP Receptor 3 4
  • P2RU1 3 4
  • P2U1 3 4
  • P2Y2 3 4
  • Purinergic Receptor P2Y2 3
  • P2U Nucleotide Receptor 3
  • Purinergic Receptor 4
  • Purinoceptor P2Y2 3
  • P2Y2R 3
  • HP2U 3
  • P2UR 3
  • P2U 3

External Ids for P2RY2 Gene

Previous GeneCards Identifiers for P2RY2 Gene

  • GC11P075255
  • GC11P074469
  • GC11P073152
  • GC11P072655
  • GC11P072606
  • GC11P072929
  • GC11P069224

Summaries for P2RY2 Gene

Entrez Gene Summary for P2RY2 Gene

  • The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, found on many cell types, is activated by ATP and UTP and is reported to be overexpressed on some cancer cell types. It is involved in many cellular functions, such as proliferation, apoptosis and inflammation. Three transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Mar 2013]

GeneCards Summary for P2RY2 Gene

P2RY2 (Purinergic Receptor P2Y, G-Protein Coupled, 2) is a Protein Coding gene. Diseases associated with P2RY2 include lacrimal apparatus disease and dry eye syndrome. Among its related pathways are Signaling by GPCR and GPCR Pathway. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is PTAFR.

UniProtKB/Swiss-Prot for P2RY2 Gene

  • Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP

Tocris Summary for P2RY2 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY2 Gene

Genomics for P2RY2 Gene

Regulatory Elements for P2RY2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for P2RY2 Gene

Chromosome:
11
Start:
73,216,448 bp from pter
End:
73,242,427 bp from pter
Size:
25,980 bases
Orientation:
Plus strand

Genomic View for P2RY2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for P2RY2 Gene

Proteins for P2RY2 Gene

  • Protein details for P2RY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41231-P2RY2_HUMAN
    Recommended name:
    P2Y purinoceptor 2
    Protein Accession:
    P41231
    Secondary Accessions:
    • B2R9W3
    • Q96EM8

    Protein attributes for P2RY2 Gene

    Size:
    377 amino acids
    Molecular mass:
    42273 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY2 Gene

neXtProt entry for P2RY2 Gene

Proteomics data for P2RY2 Gene at MOPED

Post-translational modifications for P2RY2 Gene

  • Ubiquitination at Lys 227
  • Glycosylation at Asn 9 and Asn 13
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY2 Gene

Antibody Products

No data available for DME Specific Peptides for P2RY2 Gene

Domains & Families for P2RY2 Gene

Gene Families for P2RY2 Gene

Protein Domains for P2RY2 Gene

Suggested Antigen Peptide Sequences for P2RY2 Gene

Graphical View of Domain Structure for InterPro Entry

P41231

UniProtKB/Swiss-Prot:

P2RY2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY2: view

Function for P2RY2 Gene

Molecular function for P2RY2 Gene

GENATLAS Biochemistry:
purinoceptor P2Y type 2,group 3,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly responding to UTP,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP

Gene Ontology (GO) - Molecular Function for P2RY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 7779087
GO:0004930 G-protein coupled receptor activity --
GO:0005524 ATP binding IEA --
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
GO:0045030 UTP-activated nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY2: view
genes like me logo Genes that share phenotypes with P2RY2: view

Animal Models for P2RY2 Gene

MGI Knock Outs for P2RY2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for P2RY2 Gene

Localization for P2RY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY2 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY2 Gene COMPARTMENTS Subcellular localization image for P2RY2 gene
Compartment Confidence
plasma membrane 5
extracellular 3
cytosol 2
endosome 2
lysosome 2
mitochondrion 2
vacuole 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for P2RY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005764 lysosome IEA --
GO:0005769 early endosome IEA --
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with P2RY2: view

Pathways & Interactions for P2RY2 Gene

genes like me logo Genes that share pathways with P2RY2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for P2RY2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001701 in utero embryonic development IEA --
GO:0006873 cellular ion homeostasis TAS 8159738
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with P2RY2: view

No data available for SIGNOR curated interactions for P2RY2 Gene

Drugs & Compounds for P2RY2 Gene

(32) Drugs for P2RY2 Gene - From: NovoSeek, IUPHAR, DGIdb, DrugBank, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Suramin Approved Pharma Activator, antagonist, Target 18
Isoproterenol Approved Pharma Full agonist, Agonist 15
Nitric Oxide Approved Pharma 540
Adenine Approved Nutra 0
Uridine triphosphate Experimental Pharma 0

(30) Additional Compounds for P2RY2 Gene - From: NovoSeek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Up<sub>4</sub>dC
Full agonist, Agonist
Up<sub>4</sub>U
Full agonist, Agonist
UTP
Full agonist, Agonist
UTPgammaS
Full agonist, Agonist
2-Methylthioadenosine diphosphate trisodium salt
475193-31-8
genes like me logo Genes that share compounds with P2RY2: view

Transcripts for P2RY2 Gene

Unigene Clusters for P2RY2 Gene

Purinergic receptor P2Y, G-protein coupled, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c · 4d
SP1: - -
SP2: -
SP3: -

Relevant External Links for P2RY2 Gene

GeneLoc Exon Structure for
P2RY2
ECgene alternative splicing isoforms for
P2RY2

Expression for P2RY2 Gene

mRNA expression in normal human tissues for P2RY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY2 Gene

This gene is overexpressed in Muscle - Skeletal (x11.6), Esophagus - Mucosa (x7.6), and Vagina (x4.7).

SOURCE GeneReport for Unigene cluster for P2RY2 Gene Hs.339

mRNA Expression by UniProt/SwissProt for P2RY2 Gene

P41231-P2RY2_HUMAN
Tissue specificity: Spleen, testis, kidney, liver, lung, heart and brain
genes like me logo Genes that share expression patterns with P2RY2: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for P2RY2 Gene

Orthologs for P2RY2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia P2RY2 35
  • 89.1 (n)
  • 86.7 (a)
P2RY2 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY2 35
  • 89.48 (n)
  • 89.66 (a)
P2Y2 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia P2ry2 35
  • 85.52 (n)
  • 90.62 (a)
P2ry2 16
P2ry2 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia P2RY2 35
  • 99.56 (n)
  • 100 (a)
P2RY2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2ry2 35
  • 85.38 (n)
  • 89.04 (a)
oppossum
(Monodelphis domestica)
Mammalia P2RY2 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia P2RY2 36
  • 72 (a)
OneToOne
chicken
(Gallus gallus)
Aves P2RY2 35
  • 68.31 (n)
  • 70.16 (a)
P2RY2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75941 35
p2ry2 35
  • 64.36 (n)
  • 62.71 (a)
zebrafish
(Danio rerio)
Actinopterygii P2RY2 (1 of 3) 36
  • 48 (a)
OneToMany
P2RY2 (2 of 3) 36
  • 44 (a)
OneToMany
P2RY2 (3 of 3) 36
  • 45 (a)
OneToMany
Species with no ortholog for P2RY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY2 Gene

ENSEMBL:
Gene Tree for P2RY2 (if available)
TreeFam:
Gene Tree for P2RY2 (if available)

Paralogs for P2RY2 Gene

(18) SIMAP similar genes for P2RY2 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for P2RY2 Gene

genes like me logo Genes that share paralogs with P2RY2: view

Variants for P2RY2 Gene

Sequence variations from dbSNP and Humsavar for P2RY2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs480305 -- 73,218,998(+) AATCT(C/G)GCAAA intron-variant, upstream-variant-2KB
rs498145 -- 73,220,822(+) CTCCT(A/G)CCCTG intron-variant
rs507126 -- 73,219,572(+) AGGAG(C/T)CTCCC intron-variant, upstream-variant-2KB
rs508859 -- 73,219,761(+) CCCTG(A/G)CCTGT intron-variant, upstream-variant-2KB
rs557451 -- 73,216,074(-) TTTGC(C/T)TTTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for P2RY2 Gene

Variant ID Type Subtype PubMed ID
nsv832208 CNV Gain 17160897
nsv518659 CNV Gain 19592680

Variation tolerance for P2RY2 Gene

Residual Variation Intolerance Score: 53.95% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.69; 82.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RY2 Gene

HapMap Linkage Disequilibrium report
P2RY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY2 Gene

Disorders for P2RY2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for P2RY2 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
lacrimal apparatus disease
  • lacrimal apparatus diseases
dry eye syndrome
  • tear film insufficiency
cystic fibrosis
  • pseudomonas aeruginosa chronic infection by, in cystic fibrosis
- elite association
Search P2RY2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for P2RY2

Genetic Association Database (GAD)
P2RY2
Human Genome Epidemiology (HuGE) Navigator
P2RY2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
P2RY2
genes like me logo Genes that share disorders with P2RY2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RY2 Gene

Publications for P2RY2 Gene

  1. P2 receptors activated by uracil nucleotides--an update. (PMID: 16475938) Brunschweiger A. … MA1ller C.E. (Curr. Med. Chem. 2006) 23 25 67
  2. Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. (PMID: 8159738) Parr C.E. … Turner J.T. (Proc. Natl. Acad. Sci. U.S.A. 1994) 2 23 67
  3. UTP controls cell surface distribution and vasomotor activity of the human P2Y2 receptor through an epidermal growth factor receptor-transregulated mechanism. (PMID: 19996104) Norambuena A. … Huidobro-Toro J.P. (J. Biol. Chem. 2010) 23 67
  4. Ion transport regulation by P2Y receptors, protein kinase C and phosphatidylinositol 3-kinase within the semicircular canal duct epithelium. (PMID: 20398257) Pondugula S.R. … Marcus D.C. (BMC Res Notes 2010) 23 67
  5. ATP modulates transcription factors through P2Y2 and P2Y4 receptors via PKC/MAPKs and PKC/Src pathways in MCF-7 cells. (PMID: 19900397) Scodelaro Bilbao P. … Santillan G. (Arch. Biochem. Biophys. 2010) 23 67

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