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P2RY2 Gene

protein-coding GIFtS: 68

GC11P072606

purinergic receptor P2Y, G-protein coupled, 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
HP2U ^²
MGC20088 ^²
MGC40010 ^²
P2RU1 ^², ³
P2U ^¹, ², ⁵
P2U1 ^², ³
P2UR ^²
P2Y2 ^², ³, ⁵
P2Y2R ^²

Descriptions
ATP receptor ^², ³
P2U nucleotide receptor ^²
P2U purinoceptor 1 ^², ³
P2Y purinoceptor 2 ^²
Purinergic receptor ^³
purinergic receptor P2Y, G-protein coupled, 2 ^²
purinergic receptor P2Y2 ^²
purinoceptor P2Y2 ^²

External Ids
HGNC: 8541¹
Entrez Gene: 5029²
UniProtKB: P41231³
Ensembl: ENSG00000175591⁷

Search outside databases for aliases for P2RY2 gene

Previous GC identifers: GC11P075255 GC11P074469 GC11P073152 GC11P072655

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for P2RY2:

The product of this gene belongs to the family of G-protein coupled receptors. This family has

several receptor subtypes with different pharmacological selectivity, which overlaps in some

cases, for various adenosine and uridine nucleotides. This receptor is responsive to both

adenosine and uridine nucleotides. It may participate in control of the cell cycle of endometrial

carcinoma cells. Three transcript variants encoding the same protein have been identified for this

gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: P2RY2_HUMAN, P41231

Function: Receptor for ATP and UTP coupled to G-proteins that activate a

phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP >

ATP-gamma-S >> 2-methylthio-ATP = ADP

Gene Wiki entry for P2RY2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the P2RY2 gene

Entrez Gene cytogenetic band: 11q13.5-q14.1 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.5-q14.1

P2RY2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P072606: (about GC identifiers)

Start:	72,606,992 bp from pter
End:	72,625,045 bp from pter
Size:	18,054 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.8 NT_033927.7

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: P2RY2_HUMAN, P41231 (See protein sequence)

Recommended Name: P2Y purinoceptor 2

Size: 377 amino acids; 42290 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

1Z8E (3D)

Secondary accessions: B2R9W3 Q96EM8

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_002555.2 NP_788085.1 NP_788086.1

ENSEMBL proteins:

ENSP00000377221 ENSP00000377222 ENSP00000310305

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant P2RY2 Protein
	Sigma-Aldrich CompoZr ZFN for P2RY2
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (P2Y2)
	Human Recombinant Proteins from Abnova (P2RY2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	8159738

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Antibodies for P2RY2:

	Invitrogen Antibodies for P2RY2
	Millipore Mono- and Polyclonal Antibodies for the study of P2RY2
	Sigma-Aldrich Antibodies for P2RY2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (P2Y2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for P2RY2

Assays for P2RY2:

	Invitrogen Assays for P2RY2
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P41231

ProtoNet protein and cluster: P41231

2 Blocks protein families:

IPB000356 P2Y2 purinoceptor signature

IPB002286 P2 purinoceptor signature

UniProtKB/Swiss-Prot: P2RY2_HUMAN, P41231

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RY2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RY2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002564

Applied Biosystems Silencer® siRNAs for P2RY2

Sigma-Aldrich siRNA and siRNA Panels for P2RY2

Sigma-Aldrich shRNA Panels and shRNA for P2RY2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for P2RY2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002564
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002564
untagged cDNA clones in CMV expression vector (see all 3): NM_002564

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002564

UniProtKB/Swiss-Prot: P2RY2_HUMAN, P41231

Function: Receptor for ATP and UTP coupled to G-proteins that activate a

phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP >

ATP-gamma-S >> 2-methylthio-ATP = ADP

Genatlas biochemistry entry for P2RY2:

purinoceptor P2Y type 2,group 3,metabotropic,expressed in bone,osteoblastic and brain cell

lines,predominantly responding to UTP,G protein coupled receptor superfamily

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for P2ry2):

homeostasis/metabolism

nervous system

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	7779087
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0045028	purinergic nucleotide receptor activity, G-protein coupled	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for P2RY2 (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling

GeneDecks P2RY2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for P2RY2

5/44 Interacting proteins for P2RY2 (ENSP00000310305³ P41231²) via UniProtKB, MINT, and/or STRING (see all 44 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC9A3R1	O14745²	MINT-1796602
ADA	ENSP00000361965³	STRING (score=.956)
SRC	ENSP00000362659³	STRING (score=.947)
P2RX4	ENSP00000336607³	STRING (score=.927)
ENPP3	ENSP00000350265³	STRING (score=.925)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006873	cellular ion homeostasis	TAS	8159738
GO:0007165	signal transduction	IEA	--
GO:0007200	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	TAS	8159738

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for P2RY2:

Antagonist Agonist

Compounds for P2RY2 available from Tocris Bioscience

Compound	Action	CAS number
UTPgammaS trisodium salt	Selective P2Y2/4 agonist
Suramin hexasodium salt	Non-selective P2 antagonist	[129-46-4]
2-Methylthioadenosine triphosphate tetrasodium salt	P2 purinergic agonist	[43170-89-4]
PPADS tetrasodium salt	P2 purinergic antagonist	[149017-66-3]
2-ThioUTP tetrasodium salt	Potent and selective P2Y2 agonist	[35763-29-2]

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10/24 Novoseek chemical compound relationships for P2RY2 gene (see all 24 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mrs2279	90.81	1	11959804 (1)
2-methylthio-atp	86.72	2	11032896 (1)
utp.gamma.s	83.22	2	10869373 (1)
atpgammas	82.20	4	14710912 (2), 10869373 (1)
atp	80.99	52	10540220 (3), 8557776 (2), 17170310 (2), 8723843 (2) (see all 39)
datpalphas	80.25	1	9154346 (1)
adp	77.07	8	8750911 (1), 9108793 (1), 8058061 (1), 12691958 (1) (see all 6)
uridine diphosphate	74.35	4	16543499 (1), 18604596 (1)
2-mesadp	67.91	1	11877327 (1)
ribose	59.13	5	16359641 (2), 11985476 (1), 18514530 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RY2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RY2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002564

Sigma-Aldrich siRNA and siRNA Panels for P2RY2

Sigma-Aldrich shRNA Panels and shRNA for P2RY2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002564 NM_176071 NM_176072

REFSEQ mRNAs for P2RY2 gene (3 alternative transcripts):

NM_002564.2 NM_176071.1 NM_176072.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002564 NM_176071 NM_176072

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_002564
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_002564
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_002564

Additional cDNA sequence:

AK313942.1 AY136753.1 BC012104.1 BC028135.1 U07225.1

3 DOTS entries:

DT.208493 DT.97806314 DT.95366177

24/35 AceView cDNA sequences (see all 35 ):

BC028135 CA314211 BM769746 NM_176071 NM_176072 AI680372 BE741687 BQ083469

NM_002564 BM826753 BX102461 AI590582 BF988939 F22708 BC012104 BI907874

AI743321 U07225 AY136753 CF147799 BF791674 BM851506 AI830220 R70505

highest scoring ESTs for P2RY2:

U07225 AI590582 AI680372 AI743321 AI830220 AV715065 AW890499 AY136753 BC012104 BC028135

Unigene Cluster for P2RY2:

Purinergic receptor P2Y, G-protein coupled, 2

Hs.339 [show with all ESTs]

Unigene Representative Sequence: NM_176072

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for P2RY2

ExUns:	1	^	2	^	3	^	4a	·	4b	·	4c	·	4d
SP1:			-				-
SP2:			-
SP3:							-

About this scheme

ECgene alternative splicing isoforms for P2RY2

3 Ensembl transcripts including schematic representations:

ENST00000393596 ENST00000393597 ENST00000311131

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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P2RY2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for P2RY2

¹ / ² / ³

3 probe-sets matching P2RY2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36292_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U07225	1.00	1.00	1.00	1
206277_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002564	0.60	1.00	0.82	1
206277_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks P2RY2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCTAGGAGC

SOURCE GeneReport for Unigene cluster: Hs.339
Expression variation in blood from EXPOLDB for P2RY2
UniProtKB/Swiss-Prot: P2RY2_HUMAN, P41231
Tissue specificity: Spleen, testis, kidney, liver, lung, heart and brain

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for P2RY2 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	P2RY2¹	--	purinergic receptor P2Y, G-protein coupled, 2	89.39(n) 89.39(a)	485203 XM_542321.2 XP_542321.2
chimpanzee (Pan troglodytes)	P2RY2¹	--	purinergic receptor P2Y, G-protein coupled, 2	99.47(n) 99.73(a)	466702 XM_522101.2 XP_522101.1
cow (Bos taurus)	P2RY2¹	--	purinergic receptor P2Y, G-protein coupled, 2	89.1(n) 86.44(a)	282638 XM_612432.3 XP_612432.1
rat (Rattus norvegicus)	P2ry2¹	--	purinergic receptor P2Y, G-protein coupled 2	85.29(n) 88.77(a)	29597 NM_017255.1 NP_058951.1
mouse (Mus musculus)	P2ry2^{1, 5}	7⁵	purinergic receptor P2Y, G-protein coupled 2^{1, 5}	85.52(n)¹ 90.35(a)¹	18442¹ NM_008773.3¹ NP_032799.2¹ AK005013⁵ AK017378⁵ (see all 11)

About this table Species with no ortholog for P2RY2

ENSEMBL Gene Tree for P2RY2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for P2RY2 gene

P2RY4² P2RY1² P2RY6²

Pseudogenes

1 related pseudogene

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/97 NCBI SNPs in P2RY2 are shown (see all 97 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 76)

AB	SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs2511241^1,2	C,F,H	72622989(+)	`CGTGCT/CTGGGC`	3	L/P	mis¹ ese³		12		NA EA EU WA	2354
	rs1626154^1,2	A,C,F	72623852(-)	`CCTGCG/AGCGAG`	3	C/R	mis¹ ese³		4		EA NA MN	234
	rs3741156^1,2	C,F	72623788(+)	`CAGAGG/CCTCGT`	3	S/R	mis¹ ese³		8		NA EA EU WA	710
	rs1790062^1,2	C	72606573(+)	`GAGGTG/ACGTCC`	3	--	ng5¹		3		MN NA EA	364
--	rs7948393^1,2	C	72607095(+)	`CACCCC/TGAGAG`	3	--	ut5¹ ng5¹ ese³		0	--	--	--	--
	rs1783596^1,2	A,C,F,H	72623668(+)	`TTCCGT/CTCGCT`	3	R/R	syn¹		11		MN EA NA EU WA	2456
	rs17244555^1,2	C,F,H	72623956(+)	`GCTGGT/AAGCGA`	3	G/G	syn¹ ese³		12		NA EU EA WA	1038
	rs35545480^1,2	F	72623404(+)	`TGCCAC/TGACAC`	3	H/H	syn¹		1		NA	46
	rs1625496^1,2	A,C,F,H,O	72614658(+)	`ACAATG/ATATGG`	3	--	int¹		16		EU EA WA NA	1568
	rs2510883^1,2	A,C,F,H	72612562(+)	`TAATTA/GGAACA`	3	--	int¹		8		EU EA WA	838

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HapMap Linkage Disequilibrium images for P2RY2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600041

8 Novoseek disease relationships for P2RY2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
astrocytoma	66.28	7	8913364 (1), 11711032 (1), 15778502 (1), 16607854 (1) (see all 7)
dry eye syndromes	44.94	1	12369950 (1)
cystic fibrosis	38.32	3	8159738 (1), 12369950 (1), 7809171 (1)
glioma	15.46	4	11159687 (2), 8913364 (1), 8752584 (1)
tumors	1.97	3	16920697 (2), 12880424 (1)
cancer	0.95	1	17382903 (1)
inflammation	0.00	3	15841322 (1), 17599409 (1), 16920697 (1)
atherosclerosis	0.00	1	15841322 (1)

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Human Genome Epidemiology Navigator: P2RY2 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/205 PubMed articles for P2RY2 gene (see all 205 ):

Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. (PubMed id 8159738)^{1, 2, 3, 4} Parr C.E.... Turner J.T. (1994)
Cloning and expression of a human P2U nucleotide receptor, a target for cystic fibrosis pharmacotherapy. (PubMed id 7809171)^{1, 3, 4} Parr C.E.... Turner J.T. (1994)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Chromosomal localization of the human P2y6 purinoceptor gene and phylogenetic analysis of the P2y purinoceptor family. (PubMed id 9286708)^{2, 3} Somers G.R....Venter D.J. (1997)
The P2Y2 nucleotide receptor requires interaction with alpha v integrins to access and activate G12. (PubMed id 17452627)^{1, 3} Liao Z....Erb L. (2007)
The P2Y2 nucleotide receptor interacts with alphav integrins to activate Go and induce cell migration. (PubMed id 16186116)^{1, 3} Bagchi S....Erb L. (2005)
An RGD sequence in the P2Y(2) receptor interacts with alpha(V)beta(3) integrins and is required for G(o)-mediated signal transduction. (PubMed id 11331301)^{1, 3} Erb L....Weisman G.A. (2001)
Distribution of P2Y receptor subtypes on haematopoietic cells. (PubMed id 9535005)^{1, 3} Jin J....Kunapuli S.P. (1998)
P2Y2 nucleotide receptor activation up-regulates vascular cell adhesion molecular-1 expression and enhances lymphocyte adherence to a human submandibular gland cell line. (PubMed id 17599409)^{1, 3} Baker O.J....Weisman G.A. (2008)
Human keratinocytes express multiple P2Y-receptors: evidence for functional P2Y1, P2Y2, and P2Y4 receptors. (PubMed id 12603858)^{1, 3} Burrell H.E....Sharpe G.R. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5029	HGNC: 8541	AceView: P2RY2	Ensembl:ENSG00000175591	euGenes: HUgn5029
ECgene: P2RY2	H-InvDB: P2RY2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for P2RY2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for P2RY2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for P2RY2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for P2RY2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for P2RY2		Antibodies for P2RY2
	Explore super-pooled esiRNAs		Proteins for P2RY2
	Lentivirus-delivered shRNAs for P2RY2		Small molecules for P2RY2
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (P2RY2)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (P2Y2)
	Antibodies (P2Y2)

Search OriGene for P2RY2

Tocris compounds for P2RY2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for P2RY2

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P2RY2 Gene at Home site.
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P2RY2 Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for P2RY2

Summaries
for P2RY2

Genomic Location
for P2RY2

Proteins
for P2RY2

Protein Domains/
Families
for P2RY2

Gene Function
for P2RY2

Pathways & Interactions
for P2RY2

Drugs & Compounds
for P2RY2

Transcripts
for P2RY2

Expression
for P2RY2

Orthologs
for P2RY2

Paralogs
for P2RY2

SNPs/Variants
for P2RY2

Disorders & Mutations
for P2RY2

Medical News
for P2RY2

Publications
for P2RY2

Search for P2RY2

Genome Databases showing P2RY2

Other Databases showing P2RY2

Specialized Databases showing P2RY2

Licensable Technologies
for P2RY2

Services
for P2RY2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

P2RY2 Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor P2RY2

Summariesfor P2RY2

Genomic Locationfor P2RY2

Proteinsfor P2RY2

Protein Domains/Familiesfor P2RY2

Gene Functionfor P2RY2

Pathways & Interactionsfor P2RY2

Drugs & Compoundsfor P2RY2

Transcriptsfor P2RY2

Expression for P2RY2

Orthologsfor P2RY2

Paralogsfor P2RY2

SNPs/Variantsfor P2RY2

Disorders & Mutationsfor P2RY2

Medical Newsfor P2RY2

Publicationsfor P2RY2

Search for P2RY2

Genome Databases showing P2RY2

Other Databases showing P2RY2

Specialized Databases showing P2RY2

Licensable Technologiesfor P2RY2

Servicesfor P2RY2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for P2RY2

Summaries
for P2RY2

Genomic Location
for P2RY2

Proteins
for P2RY2

Protein Domains/
Families
for P2RY2

Gene Function
for P2RY2

Pathways & Interactions
for P2RY2

Drugs & Compounds
for P2RY2

Transcripts
for P2RY2

Expression
for P2RY2

Orthologs
for P2RY2

Paralogs
for P2RY2

SNPs/Variants
for P2RY2

Disorders & Mutations
for P2RY2

Medical News
for P2RY2

Publications
for P2RY2

Licensable Technologies
for P2RY2

Services
for P2RY2