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P2RY14 Gene

protein-coding   GIFtS: 57

GC03M152412
purinergic receptor P2Y, G-protein coupled, 14
(Previous name: G protein-coupled receptor 105 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: GPR105)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
GPR105 2, 3
KIAA0001 1, 2, 3
P2Y14 2, 3
Descriptions
G protein coupled receptor for UDP-glucose 2
G protein-coupled receptor 105 1, 2
G-protein coupled receptor 105 3
P2Y purinoceptor 14 2
P2Y(14) receptor 2
P2Y14 receptor 2
UDP-glucose receptor 3
purinergic receptor P2Y, G-protein coupled, 14 2
External Ids
HGNC: 164421
Entrez Gene: 99342
UniProtKB: Q153913
Ensembl: ENSG000001749447
Search outside databases for aliases for P2RY14 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for P2RY14:
The product of this gene belongs to the family of G-protein coupled receptors, which contains
several receptor subtypes with different pharmacological selectivity for various adenosine and
uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other
UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system
functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it
may also play a role in neuroimmune function. Two transcript variants encoding the same protein
have been identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391
Function: Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP,
ADP, UTP or ATP

Gene Wiki entry for P2RY14

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the P2RY14 gene  

Entrez Gene cytogenetic band: 3q24-q25.1   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q21-q25

P2RY14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M152412:     (about GC identifiers)

Start:
152,412,595 bp from pter
End:
152,478,920 bp from pter
Size:
66,326 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391 (See protein sequence)
Recommended Name: P2Y purinoceptor 14  
Size: 338 amino acids; 38971 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
PDB structures from and Proteopedia :
2B6V (3D)    
Secondary accessions: Q8IYT7

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001074924.1  NP_055694.3  


    ENSEMBL proteins: 
    ENSP00000308361 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (GPCR GPR105 )
    Human Recombinant Proteins from Abnova (P2RY14)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane NAS10753868
    About this table

    Antibodies for P2RY14: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of P2RY14
    Sigma-Aldrich Antibodies for P2RY14
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (GPCR GPR105 ), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibody for P2RY14

    Assays for P2RY14: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_supfam
     IPR000276 7TM_GPCR_Rhodpsn
     IPR002286 P2_purnocptor
     IPR005466 UDPG_rcpt


       GeneDecks  P2RY14 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q15391

    ProtoNet protein and cluster: Q15391

    1 Blocks protein family: IPB005466 UDP-glucose receptor signature

    UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391
    Similarity: Belongs to the G-protein coupled receptor 1 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (P2RY14)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (P2RY14)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001081455

                  Applied Biosystems Silencer® siRNAs for P2RY14

                  Sigma-Aldrich siRNA and siRNA Panels for P2RY14  
                         Sigma-Aldrich shRNA Panels and shRNA for P2RY14  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for P2RY14
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001081455
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001081455
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001081455 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_014879

    UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391
    Function: Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP,
    ADP, UTP or ATP

    4 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0004930 G-protein coupled receptor activity IEA--
    GO:0045028 purinergic nucleotide receptor activity, G-protein coupled IEA--
    GO:0045029 UDP-activated nucleotide receptor activity NAS10753868
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Kegg Pathway  (Kegg details for P2RY14):
     hsa04080 Neuroactive ligand-receptor interaction

       GeneDecks  P2RY14 for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  P2RY14 


    3 Interacting proteins for P2RY14 (ENSP000003083613) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    P2RX1ENSP000002255383STRING (score=.741)
    ADCY2ENSP000003719713STRING (score=.738)
    --ENSP000003566473STRING (score=.71)
    About this table

    3 Gene Ontology (GO) biological process terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955 immune response IEA--
    GO:0007165 signal transduction IEA--
    GO:0007186 G-protein coupled receptor protein signaling pathway NAS10753868
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Sigma-Aldrich Small Molecules for P2RY14:
    Antagonist Agonist

    Compounds for P2RY14 available from Tocris Bioscience
    CompoundAction CAS number
    UDP disodium saltEndogenous ligand; competitive antagonist at P2Y14 receptors[27821-45-0]
    Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
    2-Methylthioadenosine triphosphate tetrasodium saltP2 purinergic agonist[43170-89-4]
    PPADS tetrasodium saltP2 purinergic antagonist[149017-66-3]
    MRS 2690Potent P2Y14 agonist
    About this table


    3 Novoseek chemical compound relationships for P2RY14 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    udpglucose 88.20 7 11735218 (1), 12559763 (1), 14559350 (1), 16263727 (1) (see all 5)
    pyrimidine 53.55 2 12369950 (1), 16475938 (1)
    calcium 0.00 2 12902497 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (P2RY14)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (P2RY14)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001081455

                  Sigma-Aldrich siRNA and siRNA Panels for P2RY14  
                         Sigma-Aldrich shRNA Panels and shRNA for P2RY14  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001081455  NM_014879  

    REFSEQ mRNAs for P2RY14 gene (2 alternative transcripts): 

    NM_001081455.1   NM_014879.3   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001081455  NM_014879  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001081455
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001081455
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_001081455 

    Additional cDNA sequence: 

    AK289617.1 BC034989.2 D13626.1 EF577400.1 

    4 DOTS entries:

    DT.308482  DT.100752507  DT.100752506  DT.92414697 

    24/30 AceView cDNA sequences (see all 30 ):

    AI686699 AI167543 AI277229 BC034989 CB215819 BM783128 NM_014879 BX098156 
    BF594630 AA026830 CB992700 AU138895 CD110153 BG621304 D13626 BX500840 
    AA027011 AL598208 BG205036 BQ005549 AV759275 AV756028 BP345407 AU157802 

    highest scoring ESTs for P2RY14:

    D13626 BC034989 BI459179 AA026830 AA027011 AI167543 AI277229 AI686699 AL598208 AU138895 

    Unigene Cluster for P2RY14:

    Purinergic receptor P2Y, G-protein coupled, 14
    Hs.2465  [show with all ESTs]
    Unigene Representative Sequence: NM_001081455


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000309170  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    P2RY14 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for P2RY14

    1 / 2 / 3

    3 probe-sets matching P2RY14 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    33462_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 D13626 1.00 1.00 1.00 1

    206637_at2, 3 U133-A 1 1.00 1.00 -- -- NM_014879 0.60 1.00 0.82 1

    206637_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: CTTTACTGTC

    SOURCE GeneReport for Unigene cluster: Hs.2465

    Expression variation in blood from EXPOLDB for P2RY14

    UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391
    Tissue specificity: Highest expression in the placenta, adipose tissue, stomach and intestine,
    intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for P2RY14 gene from 5/7 species (see all 7 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    P2RY141   -- purinergic receptor P2Y, G-protein coupled, 14 84.52(n)
    83.73(a)
    485717  XM_542838.2  XP_542838.2 
    chimpanzee
    (Pan troglodytes)
    P2RY141   -- purinergic receptor P2Y, G-protein coupled, 14 98.82(n)
    99.11(a)
    738743  XM_001145005.1  XP_001145005.1 
    cow
    (Bos taurus)
    P2RY141   -- purinergic receptor P2Y, G-protein coupled, 14 81.9(n)
    79.23(a)
    767936  NM_001077009.1  NP_001070477.1 
    rat
    (Rattus norvegicus)
    P2ry141   -- purinergic receptor P2Y, G-protein coupled, 14 79.86(n)
    80.55(a)
    171108  NM_133577.1  NP_598261.1 
    mouse
    (Mus musculus)
    P2ry141, 5 3 (29.50 cM)5
    purinergic receptor P2Y, G-protein coupled, 141, 5 81.56(n)1
    83.14(a)1
    1407951  NM_001008497.11  NP_001008497.11 
     AA1397295  AF1772115  (see all 12)
    About this table        Species with no ortholog for P2RY14

    ENSEMBL Gene Tree for P2RY14
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for P2RY14 gene
    GPR1712  P2RY132  GPR872  P2RY122  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section

      --
    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 610116

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/28 PubMed articles for P2RY14 gene (see all 28 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 9934 HGNC: 16442 AceView: P2RY14 Ensembl:ENSG00000174944 euGenes: HUgn9934
    ECgene: P2RY14 H-InvDB: P2RY14
    (According to HUGE)
    About This Section

    HUGE: KIAA0001
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for P2RY14:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for P2RY14 Antibodies for P2RY14
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for P2RY14 Small molecules for P2RY14
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