Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



P2RY14 Gene

protein-coding   GIFtS: 60
GCID: GC03M150929

Purinergic Receptor P2Y, G-Protein Coupled, 14

(Previous name: G protein-coupled receptor 105)
(Previous symbol: GPR105)
  See P2RY14-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Purinergic Receptor P2Y, G-Protein Coupled, 141 2     BPR1052 5
GPR1051 2 3     KIAA00013 5
G Protein-Coupled Receptor 1051 2     G Protein Coupled Receptor For UDP-Glucose2
P2Y142 3     P2Y Purinoceptor 142
G-Protein Coupled Receptor 1052 3     P2Y(14) Receptor2
UDP-Glucose Receptor2 3     P2Y14 Receptor2

External Ids:    HGNC: 164421   Entrez Gene: 99342   Ensembl: ENSG000001749447   OMIM: 6101165   UniProtKB: Q153913   

Export aliases for P2RY14 gene to outside databases

Previous GC identifers: GC03M152412 GC03M148302


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for P2RY14 Gene:
The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor
subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor
is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated
in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem
cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same
protein have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for P2RY14 Gene:
P2RY14 (purinergic receptor P2Y, G-protein coupled, 14) is a protein-coding gene. Diseases associated with P2RY14 include usher syndrome type 3. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity and UDP-activated nucleotide receptor activity. An important paralog of this gene is GPR82.

UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391
Function: Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or
ATP

summary for P2RY14 Gene:
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine
nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13
and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10
receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4
receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13
and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades
including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They
have diverse physiological roles including regulation of platelet aggregation, muscle contraction,
neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the P2RY14 gene promoter:
         GR   SRF   RP58   C/EBPbeta   AML1a   SRF (504 AA)   POU3F1   FOXD3   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidP2RY14 promoter sequence
   Search Chromatin IP Primers for P2RY14

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat P2RY14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24-q25.1   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q21-q25

P2RY14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P2RY14 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M150929:  view genomic region     (about GC identifiers)

Start:
150,929,905 bp from pter      End:
150,996,255 bp from pter
Size:
66,351 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391 (See protein sequence)
Recommended Name: P2Y purinoceptor 14  
Size: 338 amino acids; 38971 Da
Sequence caution: Sequence=BAA02791.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for P2RY14:
2B6V (3D)    
Secondary accessions: Q8IYT7

Explore the universe of human proteins at neXtProt for P2RY14: NX_Q15391

Explore proteomics data for P2RY14 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn3, Asn161
  • Modification sites at PhosphoSitePlus

  • See P2RY14 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001074924.1  NP_055694.3  

    ENSEMBL proteins: 
     ENSP00000308361   ENSP00000408733   ENSP00000418065  
    Reactome Protein details: Q15391

    P2RY14 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for P2RY14
    OriGene Custom MassSpec
    OriGene Custom Protein Services for P2RY14
    GenScript Custom Purified and Recombinant Proteins Services for P2RY14
    Novus Biologicals P2RY14 Protein
    Novus Biologicals P2RY14 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for P2RY14

     
    Search eBioscience for Proteins for P2RY14 

     
    antibodies-online proteins for P2RY14 (3 products) 

     
    antibodies-online peptides for P2RY14

    P2RY14 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for P2RY14
    OriGene Custom Antibody Services for P2RY14
    Novus Biologicals P2RY14 Antibodies
    Search for Antibodies for P2RY14 at Abcam
    Cloud-Clone Corp. Antibodies for P2RY14
    ThermoFisher Antibodies for P2RY14
    antibodies-online antibodies for P2RY14 (44 products) 

    P2RY14 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for P2RY14
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for P2RY14
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for P2RY14
    Cloud-Clone Corp. CLIAs for P2RY14
    Search eBioscience for ELISAs for P2RY14 
    antibodies-online kits for P2RY14 (10 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    P2R: Purinergic receptors
    P2RY: GPCR / Class A : Purinergic receptors, P2Y

    IUPHAR Guide to PHARMACOLOGY protein family classification: P2Y14 receptor
    P2Y receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR005466 P2Y14_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q15391

    ProtoNet protein and cluster: Q15391

    1 Blocks protein domain: IPB005466 UDP-glucose receptor signature

    UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with P2RY14           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P2Y14_HUMAN, Q15391
    Function: Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or
    ATP

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0045028G-protein coupled purinergic nucleotide receptor activity IEA--
    GO:0045029UDP-activated nucleotide receptor activity NAS10753868
         
    Find genes that share ontologies with P2RY14           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for P2RY14:
     Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for P2ry14):
     muscle  no phenotypic analysis 

    Find genes that share phenotypes with P2RY14           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for P2RY14: P2ry14tm1.1Gac P2ry14tm1Gbtm

       genOway: Develop your customized and physiologically relevant rodent model for P2RY14

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat P2RY14 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate P2RY14:
    hsa-miR-607 hsa-miR-550a hsa-miR-4263 hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidP2RY14 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for P2RY14
    Predesigned siRNA for gene silencing in human, mouse, rat P2RY14

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for P2RY14

    Clone
    Products:
         
    OriGene clones in human, mouse for P2RY14 (see all 15)
    OriGene ORF clones in mouse, rat for P2RY14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): P2RY14 (NM_001081455)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for P2RY14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat P2RY14

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for P2RY14
    Browse ESI BIO Cell Lines and PureStem Progenitors for P2RY14 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY14

    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11612) for P2RY14 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    P2Y14_HUMAN, Q15391: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane NAS10753868

    Find genes that share ontologies with P2RY14           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for P2RY14 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    G alpha (i) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Nucleotide-like (purinergic) receptors
    Nucleotide-like (purinergic) receptors
    P2Y receptors0.00


    Find genes that share SuperPaths with P2RY14           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for P2RY14
        GPCRs, Class A Rhodopsin-like

    2 Reactome Pathways for P2RY14
        P2Y receptors
    G alpha (i) signalling events


    1 Kegg Pathway  (Kegg details for P2RY14):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY14: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for P2RY14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for P2RY14 (ENSP000003083614) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY6ENSP000003114054STRING: ENSP00000311405
    ADCY7ENSP000002542354STRING: ENSP00000254235
    ADORA1ENSP000003085494STRING: ENSP00000308549
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway NAS10753868

    Find genes that share ontologies with P2RY14           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for P2RY14 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MRS 2365Highly potent and selective P2Y1 agonist[436847-09-5]
    alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist[7292-42-4]
    UTPgammaS trisodium saltSelective P2Y2/4 agonist[1266569-94-1]
    MRS 2500 tetraammonium saltExtremely potent and selective P2Y1 antagonist[630103-23-0]
    MRS 2179 tetrasodium saltSelective P2Y1 antagonist[101204-49-3]

    Selected IUPHAR Ligands for P2RY14 (P2Y14 receptor) (see all 11)    About this table
    LigandTypeActionAffinityPubmed IDs
    PPTN
    AntagonistAntagonist9.423592514
    alpha.beta-methylene-2-thio-UDP
    AgonistFull agonist9.0419902968
    MRS2905
    AgonistAgonist919902968
    2-thio-UDP
    AgonistFull agonist8.7219902968
    MRS2690
    AgonistAgonist6.64 - 7.3117407275 22825617
    UDP-glucuronic acid
    AgonistFull agonist7.219339661
    MRS2802
    AgonistAgonist7.219902968
    UDP
    AgonistFull agonist7.1319759354
    UDP-glucose
    AgonistFull agonist7.119339661
    UDP-galactose
    AgonistFull agonist719339661

    3 Novoseek inferred chemical compound relationships for P2RY14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    udpglucose 87.9 7 11735218 (1), 12559763 (1), 14559350 (1), 16263727 (1) (see all 5)
    pyrimidine 52.9 2 12369950 (1), 16475938 (1)
    calcium 0 2 12902497 (1)



    Find genes that share compounds with P2RY14           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for P2RY14 gene (2 alternative transcripts): 
    NM_001081455.1  NM_014879.3  

    Unigene Cluster for P2RY14:

    Purinergic receptor P2Y, G-protein coupled, 14
    Hs.2465  [show with all ESTs]
    Unigene Representative Sequence: NM_001081455
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309170(uc003eyr.1 uc003eys.1) ENST00000424796 ENST00000494668

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat P2RY14 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate P2RY14:
    hsa-miR-607 hsa-miR-550a hsa-miR-4263 hsa-miR-103a-2*
    SwitchGear 3'UTR luciferase reporter plasmidP2RY14 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for P2RY14
    Predesigned siRNA for gene silencing in human, mouse, rat P2RY14
    Clone
    Products:
         
    OriGene clones in human, mouse for P2RY14 (see all 15)
    OriGene ORF clones in mouse, rat for P2RY14
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): P2RY14 (NM_001081455)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for P2RY14
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat P2RY14
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for P2RY14
    OriGene qSTAR qPCR primer pairs in human, mouse for P2RY14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat P2RY14
      QuantiTect SYBR Green Assays in human, mouse, rat P2RY14
      QuantiFast Probe-based Assays in human, mouse, rat P2RY14
    Flow Cytometry
    Products:
       

     
    eBioscience FlowRNA Probe Sets ( VA1-11612) for P2RY14 

    Additional mRNA sequence: 

    AK289617.1 BC034989.2 D13626.1 EF577400.1 

    4 DOTS entries:

    DT.308482  DT.100752507  DT.100752506  DT.92414697 

    Selected AceView cDNA sequences (see all 30):

    AI686699 CB215819 AI277229 AI167543 NM_014879 BC034989 BM783128 AU138895 
    BF594630 CD110153 CB992700 BG621304 D13626 AA027011 AA026830 BX098156 
    BX500840 AL598208 AV756028 BG205036 AV759275 BQ005549 BP345407 CD703588 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    P2RY14 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTACTGTC
    P2RY14 Expression
    About this image


    P2RY14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
     
     Placenta (Extraembryonic Tissues)
    P2RY14 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    P2RY14 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2465

    UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391
    Tissue specificity: Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels
    in the brain, spleen, lung and heart, lowest levels in the kidney

        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY14: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for P2RY14
    OriGene qSTAR qPCR primer pairs in human, mouse for P2RY14
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat P2RY14
    QuantiTect SYBR Green Assays in human, mouse, rat P2RY14
    QuantiFast Probe-based Assays in human, mouse, rat P2RY14
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for P2RY14 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia P2ry141 , 5 purinergic receptor P2Y, G-protein coupled, 141, 5 81.56(n)1
    83.14(a)1
      3 (28.96 cM)5
    1407951  NM_001287124.11  NP_001274053.11 
     591146265 
    chicken
    (Gallus gallus)
    Aves P2RY141 purinergic receptor P2Y, G-protein coupled, 14 62.41(n)
    60.53(a)
      101749627  XM_004943580.1  XP_004943637.1 
    lizard
    (Anolis carolinensis)
    Reptilia P2RY146
    purinergic receptor P2Y, G-protein coupled, 14
    54(a)
    1 ↔ 1
    3(18104637-18105647)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia p2ry141 purinergic receptor P2Y, G-protein coupled, 14 58.31(n)
    55.8(a)
      100493682  XM_002941104.2  XP_002941150.1 
    zebrafish
    (Danio rerio)
    Actinopterygii P2RY146
    purinergic receptor P2Y, G-protein coupled, 14
    43(a)
    1 ↔ 1
    15(3899128-3900054) ENSDARG00000078833


    ENSEMBL Gene Tree for P2RY14 (if available)
    TreeFam Gene Tree for P2RY14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for P2RY14 gene
    GPR822  P2RY132  GPR1712  GPR872  GPR342  P2RY122  
    13 SIMAP similar genes for P2RY14 using alignment to 3 protein entries:     P2Y14_HUMAN (see all proteins):
    P2RY13    GPR87    P2RY12    GPR171    GPR18    GPR34
    FPR2    CYSLTR1    FPR1    GPR17    GPR183    PTAFR
    LPAR6

    Find genes that share paralogs with P2RY14           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    1 SNPs for P2RY14    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357674
    A colorectal cancer sample4--see VAR_0357672 L P mis40--------

    HapMap Linkage Disequilibrium report for P2RY14 (150929905 - 150996255 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for P2RY14:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2673993CNV Deletion23128226
    esv268436CNV Insertion20981092
    dgv1520e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing P2RY14
    DNA2.0 Custom Variant and Variant Library Synthesis for P2RY14

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610116    OMIM disorders: --

    1 disease for P2RY14:    
    About MalaCards
    usher syndrome type 3


    Find genes that share disorders with P2RY14           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: P2RY14 (1 document)

    Export disorders for P2RY14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for P2RY14 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with P2RY14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. (PubMed id 11524702)1, 2 Joensuu T.... Sankila E.-M. (Am. J. Hum. Genet. 2001)
    3. A G protein-coupled receptor for UDP-glucose. (PubMed id 10753868)1, 2 Chambers J.K.... Livi G.P. (J. Biol. Chem. 2000)
    4. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (DNA Res. 1994)
    5. GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function. (PubMed id 14559350)1, 9 Moore D.J....Emson P.C. (Brain Res. Mol. Brain Res. 2003)
    6. P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. (PubMed id 12842911)1, 9 Lee B.C....Scadden D.T. (amp 2003)
    7. Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose. (PubMed id 12902497)1, 9 Skelton L....Platt A. (J. Immunol. 2003)
    8. The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion. (PubMed id 16109883)1, 9 MA1ller T....Idzko M. (Am. J. Respir. Cell Mol. Biol. 2005)
    9. Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. (PubMed id 12559763)1, 9 Abbracchio M.P....Burnstock G. (Trends Pharmacol. Sci. 2003)
    10. Creation of GPCR-based chemical sensors by directed evolution in yeast. (PubMed id 16263727)1, 9 Ault A.D. and Broach J.R. (amp 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9934 HGNC: 16442 AceView: P2RY14 Ensembl:ENSG00000174944 euGenes: HUgn9934
    ECgene: P2RY14 Kegg: 9934 H-InvDB: P2RY14

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0001

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for P2RY14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for P2RY14 gene:
    Search GeneIP for patents involving P2RY14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for P2RY14 (P2Y14/GPR105)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for P2RY14   OriGene RNAi products in human, mouse, rat for P2RY14  
     OriGene qPCR primer pairs and template standards for P2RY14   OriGene Protein Over-expression Lysate for P2RY14  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for P2RY14  
     OriGene qSTAR qPCR primer pairs in human, mouse for P2RY14   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for P2RY14   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for P2RY14   OriGene Custom Protein Services for P2RY14  

     
     
     Block miRNA regulation of human, mouse, rat P2RY14 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing P2RY14
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat P2RY14 Predesigned siRNA for gene silencing in human, mouse, rat P2RY14
     QuantiFast Probe-based Assays in human, mouse, rat P2RY14 QuantiTect SYBR Green Assays in human, mouse, rat P2RY14
     PCR Arrays including human, mouse, rat P2RY14 Search Chromatin IP Primers for P2RY14
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat P2RY14  GeneGlobe Interaction Network for P2RY14
     Regulatory tfbs in P2RY14 promoter
     GenScript Custom Purified and Recombinant Proteins Services for P2RY14 GenScript cDNA clones with any tag delivered in your preferred vector for P2RY14
     GenScript Custom Assay Services for P2RY14 GenScript Custom overexpressing Cell Line Services for P2RY14
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Tocris compounds for P2RY14
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     P2RY14 antibodies
     P2RY14 proteins
     P2RY14 lysates
     Search for Antibodies for P2RY14 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for P2RY14
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for P2RY14
     Antibodies for P2RY14
     ELISAs for P2RY14
     CLIAs for P2RY14



     Browse ESI BIO Cell Lines and PureStem Progenitors for P2RY14
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY14
     SwitchGear 3'UTR luciferase reporter plasmids for P2RY14
     SwitchGear Promoter luciferase reporter plasmids for P2RY14
     ThermoFisher Antibodies for P2RY14
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat P2RY14
     Browse compounds at ApexBio
     Search Addgene for plasmids for P2RY14
      Search eBioscience for proteins for P2RY14
      Search eBioscience for elisas for P2RY14
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for P2RY14
     antibodies-online antibodies for P2RY14 (44 products)
     antibodies-online kits for P2RY14 (10 products)
     antibodies-online peptides for P2RY14
     antibodies-online proteins for P2RY14 (3 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      P2RY14 gene at Home site.
    Version: 3.12.252 27 Nov 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4