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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

P2RY14 Gene

protein-coding   GIFtS: 60
GCID: GC03M150929

Purinergic Receptor P2Y, G-Protein Coupled, 14

(Previous name: G protein-coupled receptor 105)
(Previous symbol: GPR105)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Purinergic Receptor P2Y, G-Protein Coupled, 141 2     BPR1052
GPR1051 2 3     G Protein Coupled Receptor For UDP-Glucose2
G Protein-Coupled Receptor 1051 2     P2Y Purinoceptor 142
P2Y142 3     P2Y(14) Receptor2
G-Protein Coupled Receptor 1052 3     P2Y14 Receptor2
UDP-Glucose Receptor2 3     KIAA00013

External Ids:    HGNC: 164421   Entrez Gene: 99342   Ensembl: ENSG000001749447   OMIM: 6101165   UniProtKB: Q153913   

Export aliases for P2RY14 gene to outside databases

Previous GC identifers: GC03M152412 GC03M148302


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for P2RY14 Gene:
The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor
subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor
is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated
in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem
cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same
protein have been identified for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for P2RY14 Gene: 
P2RY14 (purinergic receptor P2Y, G-protein coupled, 14) is a protein-coding gene. Diseases associated with P2RY14 include usher syndrome type 3, and usher syndrome, and among its related super-pathways are Class A/1 (Rhodopsin-like receptors) and Signaling by GPCR. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity and UDP-activated nucleotide receptor activity. An important paralog of this gene is GPR82.

UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391
Function: Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or
ATP

summary for P2RY14 Gene:
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine
nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13
and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10
receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4
receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13
and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades
including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They
have diverse physiological roles including regulation of platelet aggregation, muscle contraction,
neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY14 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_005612.16  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the P2RY14 gene promoter:
         GR   SRF   RP58   C/EBPbeta   AML1a   SRF (504 AA)   POU3F1   FOXD3   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidP2RY14 promoter sequence
   Search SABiosciences Chromatin IP Primers for P2RY14

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat P2RY14


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24-q25.1   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q21-q25

P2RY14 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P2RY14 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M150929:  view genomic region     (about GC identifiers)

Start:
150,929,905 bp from pter      End:
150,996,255 bp from pter
Size:
66,351 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391 (See protein sequence)
Recommended Name: P2Y purinoceptor 14  
Size: 338 amino acids; 38971 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAA02791.2; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for P2RY14:
2B6V (3D)    
Secondary accessions: Q8IYT7

Explore the universe of human proteins at neXtProt for P2RY14: NX_Q15391

Explore proteomics data for P2RY14 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15391

  • P2RY14 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    P2RY14 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001074924.1  NP_055694.3  

    ENSEMBL proteins: 
     ENSP00000308361   ENSP00000408733   ENSP00000418065  
    Reactome Protein details: Q15391
    Human Recombinant Protein Products for P2RY14: 
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    Cloud-Clone Corp. Proteins for P2RY14 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane NAS10753868

    P2RY14 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    P2R: Purinergic receptors
    P2RY: GPCR / Class A : Purinergic receptors, P2Y

    IUPHAR Guide to PHARMACOLOGY protein family classification: P2Y14 receptor 
    P2Y receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002286 purinergic_P2Y_rcpt
     IPR005466 UDPG_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q15391

    ProtoNet protein and cluster: Q15391

    1 Blocks protein domain: IPB005466 UDP-glucose receptor signature

    UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391
    Similarity: Belongs to the G-protein coupled receptor 1 family


    P2RY14 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P2Y14_HUMAN, Q15391
    Function: Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or
    ATP

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0045028G-protein coupled purinergic nucleotide receptor activity IEA--
    GO:0045029UDP-activated nucleotide receptor activity NAS10753868
         
    P2RY14 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for P2RY14:
     Synthetic lethal with c-Myc af 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for P2ry14):
     muscle  no phenotypic analysis 

    P2RY14 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for P2RY14: P2ry14tm1.1Gac P2ry14tm1Gbtm

       inGenious Targeting Laboratory - Custom generated mouse model solutions for P2RY14 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for P2RY14 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.41
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.37
    G alpha (i) signalling events0.46
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    3Nucleotide-like (purinergic) receptors
    Nucleotide-like (purinergic) receptors0.75
    P2Y receptors0.75

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for P2RY14
        GPCRs, Class A Rhodopsin-like

    5/8        Reactome Pathways for P2RY14 (see all 8)
        GPCR downstream signaling
    P2Y receptors
    Signal Transduction
    Signaling by GPCR
    G alpha (i) signalling events


    1         Kegg Pathway  (Kegg details for P2RY14):
        Neuroactive ligand-receptor interaction


    P2RY14 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for P2RY14

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/143 Interacting proteins for P2RY14 (ENSP000003083614) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY4ENSP000003121264STRING: ENSP00000312126
    ADCY6ENSP000003114054STRING: ENSP00000311405
    ADCY7ENSP000002542354STRING: ENSP00000254235
    ADORA1ENSP000003085494STRING: ENSP00000308549
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway NAS10753868

    P2RY14 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    P2RY14 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for P2RY14 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MRS 2365Highly potent and selective P2Y1 agonist[436847-09-5]
    alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist[7292-42-4]
    UTPgammaS trisodium saltSelective P2Y2/4 agonist[1266569-94-1]
    MRS 2500 tetraammonium saltExtremely potent and selective P2Y1 antagonist[630103-23-0]
    MRS 2179 tetrasodium saltSelective P2Y1 antagonist[101204-49-3]

    10/11 IUPHAR Ligands for P2RY14 (P2Y14 receptor) (see all 11)    About this table 
    LigandTypeActionAffinityPubmed IDs
    PPTN
    AntagonistAntagonist9.423592514
    α.β-methylene-2-thio-UDP
    AgonistFull agonist9.0419902968
    MRS2905
    AgonistAgonist919902968
    2-thio-UDP
    AgonistFull agonist8.7219902968
    MRS2690
    AgonistAgonist6.64 - 7.3117407275 22825617
    UDP-glucuronic acid
    AgonistFull agonist7.219339661
    MRS2802
    AgonistAgonist7.219902968
    UDP
    AgonistFull agonist7.1319759354
    UDP-glucose
    AgonistFull agonist7.119339661
    UDP-galactose
    AgonistFull agonist719339661

    3 Novoseek inferred chemical compound relationships for P2RY14 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    udpglucose 87.9 7 11735218 (1), 12559763 (1), 14559350 (1), 16263727 (1) (see all 5)
    pyrimidine 52.9 2 12369950 (1), 16475938 (1)
    calcium 0 2 12902497 (1)

    Search CenterWatch for drugs/clinical trials and news about P2RY14 / P2Y14

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for P2RY14 gene (2 alternative transcripts): 
    NM_001081455.1  NM_014879.3  

    Unigene Cluster for P2RY14:

    Purinergic receptor P2Y, G-protein coupled, 14
    Hs.2465  [show with all ESTs]
    Unigene Representative Sequence: NM_001081455
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309170(uc003eyr.1 uc003eys.1) ENST00000424796 ENST00000494668

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    Additional mRNA sequence: 

    AK289617.1 BC034989.2 D13626.1 EF577400.1 

    4 DOTS entries:

    DT.308482  DT.100752507  DT.100752506  DT.92414697 

    24/30 AceView cDNA sequences (see all 30):

    CB215819 AI167543 AI277229 BM783128 AI686699 BC034989 NM_014879 AL598208 
    BF594630 BX500840 D13626 AA026830 CD110153 BG621304 AA027011 CB992700 
    BX098156 AU138895 BQ005549 AV756028 BG205036 AV759275 AU157802 CD703588 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    P2RY14 expression in normal human tissues (normalized intensities)      P2RY14 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTACTGTC
    P2RY14 Expression
    About this image


    P2RY14 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Plasmacytoid Dendritic cells Peripheral Blood
             leukocytes   
     
     Uterus (Reproductive System)
             endometrium   
     
     Spleen (Hematopoietic System)
             Conventional Dendritic Cells I Spleen
     
     Placenta (Extraembryonic Tissues)

    See P2RY14 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for P2RY14

    SOURCE GeneReport for Unigene cluster: Hs.2465

    UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391
    Tissue specificity: Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels
    in the brain, spleen, lung and heart, lowest levels in the kidney

        SABiosciences Expression via Pathway-Focused PCR Array including P2RY14: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY14

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for P2RY14 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia P2ry141 , 5 purinergic receptor P2Y, G-protein coupled, 141, 5 81.56(n)1
    83.14(a)1
      3 (28.96 cM)5
    1407951  NM_001008497.11  NP_001008497.11 
     591146265 
    chicken
    (Gallus gallus)
    Aves P2RY146
    Uncharacterized protein
    60(a)
    1 ↔ 1
    9(23026393-23027406)
    lizard
    (Anolis carolinensis)
    Reptilia P2RY146
    Uncharacterized protein
    53(a)
    1 ↔ 1
    3(18104637-18105647)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC7937501 p2Y purinoceptor 14-like 54.81(n)
    45.64(a)
      793750  XM_001333545.2  XP_001333581.2 


    ENSEMBL Gene Tree for P2RY14 (if available)
    TreeFam Gene Tree for P2RY14 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for P2RY14 gene
    GPR822  P2RY132  GPR1712  GPR872  GPR342  P2RY122  
    14 SIMAP similar genes for P2RY14 using alignment to 3 protein entries:     P2Y14_HUMAN (see all proteins):
    P2RY13    GPR87    P2RY12    GPR171    GPR18    GPR34
    FPR2    CYSLTR1    FPR1    GPR17    GPR183    PTAFR
    LPAR6    P2RY5

    P2RY14 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in P2RY14 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0357674
    A colorectal cancer sample4--see VAR_0357672 L P mis40--------

    HapMap Linkage Disequilibrium report for P2RY14 (150929905 - 150996255 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for P2RY14:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2673993CNV Deletion23128226
    esv268436CNV Insertion20981092
    dgv1520e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610116    OMIM disorders: --

    3 diseases for P2RY14:    About MalaCards
    usher syndrome type 3    usher syndrome    pertussis


    P2RY14 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: P2RY14 (1 document)

    Export disorders for P2RY14 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for P2RY14 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with P2RY14)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. (PubMed id 11524702)1, 2 Joensuu T.... Sankila E.-M. (2001)
    3. A G protein-coupled receptor for UDP-glucose. (PubMed id 10753868)1, 2 Chambers J.K.... Livi G.P. (2000)
    4. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026)1, 2 Nomura N.... Tabata S. (1994)
    5. GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function. (PubMed id 14559350)1, 9 Moore D.J....Emson P.C. (2003)
    6. P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. (PubMed id 12842911)1, 9 Lee B.C....Scadden D.T. (2003)
    7. Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose. (PubMed id 12902497)1, 9 Skelton L....Platt A. (2003)
    8. The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion. (PubMed id 16109883)1, 9 Muller T....Idzko M. (2005)
    9. Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. (PubMed id 12559763)1, 9 Abbracchio M.P....Burnstock G. (2003)
    10. Creation of GPCR-based chemical sensors by directed evolution in yeast. (PubMed id 16263727)1, 9 Ault A.D. and Broach J.R. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9934 HGNC: 16442 AceView: P2RY14 Ensembl:ENSG00000174944 euGenes: HUgn9934
    ECgene: P2RY14 Kegg: 9934 H-InvDB: P2RY14

    (According to HUGE)
    About This Section
    HUGE: KIAA0001

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for P2RY14 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for P2RY14 gene:
    Search GeneIP for patents involving P2RY14

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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