Free for academic non-profit institutions. Other users need a Commercial license

Aliases for P2RY14 Gene

Aliases for P2RY14 Gene

  • Purinergic Receptor P2Y14 2 3
  • Purinergic Receptor P2Y, G-Protein Coupled, 14 2 3 5
  • G-Protein Coupled Receptor 105 3 4
  • G Protein-Coupled Receptor 105 2 3
  • UDP-Glucose Receptor 3 4
  • GPR105 3 4
  • P2Y14 3 4
  • G Protein Coupled Receptor For UDP-Glucose 3
  • P2Y(14) Receptor 3
  • P2Y14 Receptor 3
  • KIAA0001 4
  • BPR105 3

External Ids for P2RY14 Gene

Previous HGNC Symbols for P2RY14 Gene

  • GPR105

Previous GeneCards Identifiers for P2RY14 Gene

  • GC03M152412
  • GC03M150929
  • GC03M148302

Summaries for P2RY14 Gene

Entrez Gene Summary for P2RY14 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY14 Gene

P2RY14 (Purinergic Receptor P2Y14) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and UDP-activated nucleotide receptor activity. An important paralog of this gene is PTAFR.

UniProtKB/Swiss-Prot for P2RY14 Gene

  • Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.

Tocris Summary for P2RY14 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY14 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY14 Gene

Genomics for P2RY14 Gene

Regulatory Elements for P2RY14 Gene

Promoters for P2RY14 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around P2RY14 on UCSC Golden Path with GeneCards custom track

Genomic Location for P2RY14 Gene

Chromosome:
3
Start:
151,212,115 bp from pter
End:
151,278,628 bp from pter
Size:
66,514 bases
Orientation:
Minus strand

Genomic View for P2RY14 Gene

Genes around P2RY14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY14 Gene

Proteins for P2RY14 Gene

  • Protein details for P2RY14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15391-P2Y14_HUMAN
    Recommended name:
    P2Y purinoceptor 14
    Protein Accession:
    Q15391
    Secondary Accessions:
    • Q8IYT7

    Protein attributes for P2RY14 Gene

    Size:
    338 amino acids
    Molecular mass:
    38971 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA02791.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for P2RY14 Gene

neXtProt entry for P2RY14 Gene

Proteomics data for P2RY14 Gene at MOPED

Post-translational modifications for P2RY14 Gene

  • Glycosylation at Asn 3 and Asn 161
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY14 Gene

Antibody Products

No data available for DME Specific Peptides for P2RY14 Gene

Domains & Families for P2RY14 Gene

Gene Families for P2RY14 Gene

Protein Domains for P2RY14 Gene

Suggested Antigen Peptide Sequences for P2RY14 Gene

Graphical View of Domain Structure for InterPro Entry

Q15391

UniProtKB/Swiss-Prot:

P2Y14_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY14: view

Function for P2RY14 Gene

Molecular function for P2RY14 Gene

UniProtKB/Swiss-Prot Function:
Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.

Gene Ontology (GO) - Molecular Function for P2RY14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA,IBA --
genes like me logo Genes that share ontologies with P2RY14: view
genes like me logo Genes that share phenotypes with P2RY14: view

Animal Models for P2RY14 Gene

MGI Knock Outs for P2RY14:

Animal Model Products

  • Taconic Biosciences Mouse Models for P2RY14

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for P2RY14 Gene

Localization for P2RY14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY14 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY14 Gene COMPARTMENTS Subcellular localization image for P2RY14 gene
Compartment Confidence
plasma membrane 5
extracellular 2

No data available for Gene Ontology (GO) - Cellular Components for P2RY14 Gene

Pathways & Interactions for P2RY14 Gene

genes like me logo Genes that share pathways with P2RY14: view

Pathways by source for P2RY14 Gene

Interacting Proteins for P2RY14 Gene

Gene Ontology (GO) - Biological Process for P2RY14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,NAS 10753868
genes like me logo Genes that share ontologies with P2RY14: view

No data available for SIGNOR curated interactions for P2RY14 Gene

Drugs & Compounds for P2RY14 Gene

(13) Drugs for P2RY14 Gene - From: IUPHAR, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Udp-Glucuronic Acid Experimental Pharma Full agonist, Agonist 0
MC-1 Investigational Pharma 0
2-thio-UDP Pharma Full agonist, Agonist 0
MRS2690 Pharma Agonist 0
MRS2802 Pharma Agonist 0

(9) Additional Compounds for P2RY14 Gene - From: IUPHAR, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha.beta-methylene-2-thio-UDP
Full agonist, Agonist
UDP
Agonist
2-Methylthioadenosine diphosphate trisodium salt
475193-31-8
2-Methylthioadenosine triphosphate tetrasodium salt
100020-57-3
MRS 2365
436847-09-5
genes like me logo Genes that share compounds with P2RY14: view

Transcripts for P2RY14 Gene

Unigene Clusters for P2RY14 Gene

Purinergic receptor P2Y, G-protein coupled, 14:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY14 Gene

No ASD Table

Relevant External Links for P2RY14 Gene

GeneLoc Exon Structure for
P2RY14
ECgene alternative splicing isoforms for
P2RY14

Expression for P2RY14 Gene

mRNA expression in normal human tissues for P2RY14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY14 Gene

This gene is overexpressed in Bladder (x4.4), Esophagus - Gastroesophageal Junction (x4.3), and Stomach (x4.1).

Protein differential expression in normal tissues from HIPED for P2RY14 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for P2RY14 Gene



SOURCE GeneReport for Unigene cluster for P2RY14 Gene Hs.2465

mRNA Expression by UniProt/SwissProt for P2RY14 Gene

Q15391-P2Y14_HUMAN
Tissue specificity: Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney.
genes like me logo Genes that share expression patterns with P2RY14: view

Protein tissue co-expression partners for P2RY14 Gene

Primer Products

In Situ Assay Products

Orthologs for P2RY14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY14 35
  • 98.82 (n)
  • 99.11 (a)
P2RY14 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia P2RY14 36
  • 79 (a)
OneToOne
P2RY14 35
  • 81.9 (n)
  • 79.23 (a)
dog
(Canis familiaris)
Mammalia P2RY14 35
  • 84.52 (n)
  • 83.73 (a)
P2RY14 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia P2ry14 16
P2ry14 36
  • 83 (a)
OneToOne
P2ry14 35
  • 81.56 (n)
  • 83.14 (a)
oppossum
(Monodelphis domestica)
Mammalia P2RY14 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia P2RY14 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2ry14 35
  • 79.86 (n)
  • 80.55 (a)
chicken
(Gallus gallus)
Aves P2RY14 35
  • 62.41 (n)
  • 60.53 (a)
P2RY14 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia P2RY14 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry14 35
  • 58.31 (n)
  • 55.8 (a)
zebrafish
(Danio rerio)
Actinopterygii P2RY14 36
  • 43 (a)
OneToOne
Species with no ortholog for P2RY14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY14 Gene

ENSEMBL:
Gene Tree for P2RY14 (if available)
TreeFam:
Gene Tree for P2RY14 (if available)

Paralogs for P2RY14 Gene

Paralogs for P2RY14 Gene

(13) SIMAP similar genes for P2RY14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with P2RY14: view

Variants for P2RY14 Gene

Sequence variations from dbSNP and Humsavar for P2RY14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_035767 A colorectal cancer sample

Structural Variations from Database of Genomic Variants (DGV) for P2RY14 Gene

Variant ID Type Subtype PubMed ID
dgv1520e1 CNV Complex 17122850
esv2673993 CNV Deletion 23128226
esv268436 CNV Insertion 20981092

Variation tolerance for P2RY14 Gene

Residual Variation Intolerance Score: 72.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RY14 Gene

HapMap Linkage Disequilibrium report
P2RY14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY14 Gene

Disorders for P2RY14 Gene

Relevant External Links for P2RY14

Human Genome Epidemiology (HuGE) Navigator
P2RY14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
P2RY14

No disorders were found for P2RY14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for P2RY14 Gene

Publications for P2RY14 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. P2 receptors activated by uracil nucleotides--an update. (PMID: 16475938) Brunschweiger A. … MA1ller C.E. (Curr. Med. Chem. 2006) 3 23
  3. Creation of GPCR-based chemical sensors by directed evolution in yeast. (PMID: 16263727) Ault A.D. … Broach J.R. (Protein Eng. Des. Sel. 2006) 3 23
  4. The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion. (PMID: 16109883) MA1ller T. … Idzko M. (Am. J. Respir. Cell Mol. Biol. 2005) 3 23
  5. GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function. (PMID: 14559350) Moore D.J. … Emson P.C. (Brain Res. Mol. Brain Res. 2003) 3 23

Products for P2RY14 Gene

Sources for P2RY14 Gene

Back to Top

Content