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Aliases for P2RY14 Gene

Aliases for P2RY14 Gene

  • Purinergic Receptor P2Y, G-Protein Coupled, 14 2 3
  • G-Protein Coupled Receptor 105 3 4
  • G Protein-Coupled Receptor 105 2 3
  • UDP-Glucose Receptor 3 4
  • KIAA0001 4 6
  • GPR105 3 4
  • BPR105 3 6
  • P2Y14 3 4
  • G Protein Coupled Receptor For UDP-Glucose 3
  • P2Y Purinoceptor 14 3
  • P2Y(14) Receptor 3
  • P2Y14 Receptor 3

External Ids for P2RY14 Gene

Previous HGNC Symbols for P2RY14 Gene

  • GPR105

Previous GeneCards Identifiers for P2RY14 Gene

  • GC03M152412
  • GC03M150929
  • GC03M148302

Summaries for P2RY14 Gene

Entrez Gene Summary for P2RY14 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors, which contains several receptor subtypes with different pharmacological selectivity for various adenosine and uridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and other UDP-sugars coupled to G-proteins. It has been implicated in extending the known immune system functions of P2Y receptors by participating in the regulation of the stem cell compartment, and it may also play a role in neuroimmune function. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY14 Gene

P2RY14 (Purinergic Receptor P2Y, G-Protein Coupled, 14) is a Protein Coding gene. Diseases associated with P2RY14 include usher syndrome. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity and UDP-activated nucleotide receptor activity. An important paralog of this gene is GPR34.

UniProtKB/Swiss-Prot for P2RY14 Gene

  • Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.

Tocris Summary for P2RY14 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10 receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4 receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13 and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They have diverse physiological roles including regulation of platelet aggregation, muscle contraction, neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY14 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY14 Gene

Genomics for P2RY14 Gene

Regulatory Elements for P2RY14 Gene

Genomic Location for P2RY14 Gene

Start:
151,212,117 bp from pter
End:
151,279,208 bp from pter
Size:
67,092 bases
Orientation:
Minus strand

Genomic View for P2RY14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for P2RY14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY14 Gene

Proteins for P2RY14 Gene

  • Protein details for P2RY14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15391-P2Y14_HUMAN
    Recommended name:
    P2Y purinoceptor 14
    Protein Accession:
    Q15391
    Secondary Accessions:
    • Q8IYT7

    Protein attributes for P2RY14 Gene

    Size:
    338 amino acids
    Molecular mass:
    38971 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA02791.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for P2RY14 Gene

neXtProt entry for P2RY14 Gene

Proteomics data for P2RY14 Gene at MOPED

Post-translational modifications for P2RY14 Gene

  • Glycosylation at Asn3 and Asn161
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY14 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for P2RY14 Gene

Domains for P2RY14 Gene

Gene Families for P2RY14 Gene

HGNC:
  • P2RY :GPCR / Class A : Purinergic receptors, P2Y
  • P2R :Purinergic receptors
IUPHAR :

Protein Domains for P2RY14 Gene

Suggested Antigen Peptide Sequences for P2RY14 Gene

Graphical View of Domain Structure for InterPro Entry

Q15391

UniProtKB/Swiss-Prot:

P2Y14_HUMAN :
  • Q15391
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY14: view

Function for P2RY14 Gene

Molecular function for P2RY14 Gene

UniProtKB/Swiss-Prot Function: Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.

Gene Ontology (GO) - Molecular Function for P2RY14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IBA --
GO:0045029 UDP-activated nucleotide receptor activity NAS 10753868
genes like me logo Genes that share ontologies with P2RY14: view

Phenotypes for P2RY14 Gene

MGI mutant phenotypes for P2RY14:
inferred from 2 alleles
GenomeRNAi human phenotypes for P2RY14:
genes like me logo Genes that share phenotypes with P2RY14: view

Animal Models for P2RY14 Gene

MGI Knock Outs for P2RY14:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for P2RY14 Gene

Localization for P2RY14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY14 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY14 Gene COMPARTMENTS Subcellular localization image for P2RY14 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for P2RY14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane NAS 10753868
genes like me logo Genes that share ontologies with P2RY14: view

Pathways for P2RY14 Gene

genes like me logo Genes that share pathways with P2RY14: view

Pathways by source for P2RY14 Gene

Interacting Proteins for P2RY14 Gene

Gene Ontology (GO) - Biological Process for P2RY14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway NAS 10753868
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with P2RY14: view

Compounds for P2RY14 Gene

(5) Tocris Compounds for P2RY14 Gene

Compound Action Cas Number
alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist [1343364-54-4]
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 [475193-31-8]
MRS 2179 tetrasodium salt Selective P2Y1 antagonist [1454889-37-2]
MRS 2365 Highly potent and selective P2Y1 agonist [436847-09-5]
MRS 2500 tetraammonium salt Extremely potent and selective P2Y1 antagonist [630103-23-0]

(11) IUPHAR Ligand for P2RY14 Gene

Ligand Type Action Affinity Pubmed IDs
PPTN Antagonist Antagonist 9.4
alpha.beta-methylene-2-thio-UDP Agonist Full agonist 9.04
MRS2905 Agonist Agonist 9
2-thio-UDP Agonist Full agonist 8.72
MRS2690 Agonist Agonist 7.31
UDP-glucuronic acid Agonist Full agonist 7.2
MRS2802 Agonist Agonist 7.2
UDP Agonist Full agonist 7.13
UDP-glucose Agonist Full agonist 7.1
UDP-galactose Agonist Full agonist 7
UDP N-acetyl-glucosamine Agonist Full agonist 6

(3) Novoseek inferred chemical compound relationships for P2RY14 Gene

Compound -log(P) Hits PubMed IDs
udpglucose 87.9 5
pyrimidine 52.9 2
calcium 0 1
genes like me logo Genes that share compounds with P2RY14: view

Transcripts for P2RY14 Gene

Unigene Clusters for P2RY14 Gene

Purinergic receptor P2Y, G-protein coupled, 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY14 Gene

No ASD Table

Relevant External Links for P2RY14 Gene

GeneLoc Exon Structure for
P2RY14
ECgene alternative splicing isoforms for
P2RY14

Expression for P2RY14 Gene

mRNA expression in normal human tissues for P2RY14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY14 Gene

This gene is overexpressed in Bladder (4.4), Esophagus - Gastroesophageal Junction (4.3), and Stomach (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for P2RY14 Gene

SOURCE GeneReport for Unigene cluster for P2RY14 Gene Hs.2465

mRNA Expression by UniProt/SwissProt for P2RY14 Gene

Q15391-P2Y14_HUMAN
Tissue specificity: Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney
genes like me logo Genes that share expressions with P2RY14: view

Orthologs for P2RY14 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY14 35
  • 98.82 (n)
  • 99.11 (a)
P2RY14 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia P2RY14 35
  • 81.9 (n)
  • 79.23 (a)
P2RY14 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY14 35
  • 84.52 (n)
  • 83.73 (a)
P2RY14 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia P2ry14 35
  • 81.56 (n)
  • 83.14 (a)
P2ry14 16
P2ry14 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia P2RY14 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia P2RY14 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2ry14 35
  • 79.86 (n)
  • 80.55 (a)
chicken
(Gallus gallus)
Aves P2RY14 35
  • 62.41 (n)
  • 60.53 (a)
P2RY14 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia P2RY14 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry14 35
  • 58.31 (n)
  • 55.8 (a)
zebrafish
(Danio rerio)
Actinopterygii P2RY14 36
  • 43 (a)
OneToOne
Species with no ortholog for P2RY14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY14 Gene

ENSEMBL:
Gene Tree for P2RY14 (if available)
TreeFam:
Gene Tree for P2RY14 (if available)

Paralogs for P2RY14 Gene

Paralogs for P2RY14 Gene

Selected SIMAP similar genes for P2RY14 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with P2RY14: view

Variants for P2RY14 Gene

Sequence variations from dbSNP and Humsavar for P2RY14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_035767 A colorectal cancer sample

Structural Variations from Database of Genomic Variants (DGV) for P2RY14 Gene

Variant ID Type Subtype PubMed ID
dgv1520e1 CNV Complex 17122850
esv2673993 CNV Deletion 23128226
esv268436 CNV Insertion 20981092

Relevant External Links for P2RY14 Gene

HapMap Linkage Disequilibrium report
P2RY14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY14 Gene

Disorders for P2RY14 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for P2RY14 Gene including...

Search for P2RY14 Gene in MalaCards »

Relevant External Links for P2RY14

Human Genome Epidemiology (HuGE) Navigator
P2RY14
genes like me logo Genes that share disorders with P2RY14: view

No data available for UniProtKB/Swiss-Prot for P2RY14 Gene

Publications for P2RY14 Gene

  1. P2-pyrimidinergic receptors and their ligands. (PMID: 12369950) MA1ller C.E. (Curr. Pharm. Des. 2002) 3 23
  2. Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. (PMID: 12559763) Abbracchio M.P. … Burnstock G. (Trends Pharmacol. Sci. 2003) 3 23
  3. P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. (PMID: 12842911) Lee B.C. … Scadden D.T. (Genes Dev. 2003) 3 23
  4. Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose. (PMID: 12902497) Skelton L. … Platt A. (J. Immunol. 2003) 3 23
  5. GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function. (PMID: 14559350) Moore D.J. … Emson P.C. (Brain Res. Mol. Brain Res. 2003) 3 23

Products for P2RY14 Gene

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