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Aliases & Descriptions for P2RY14
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases GPR105 2 , 3 KIAA0001 1 , 2 , 3 P2Y14 2 , 3
Descriptions G protein coupled receptor for UDP-glucose 2 G protein-coupled receptor 105 1 , 2 G-protein coupled receptor 105 3 P2Y purinoceptor 14 2 P2Y(14) receptor 2 P2Y14 receptor 2 UDP-glucose receptor 3 purinergic receptor P2Y, G-protein coupled, 14 2
Search outside databases for aliases for P2RY14 gene
Summaries for P2RY14 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for P2RY14 : The product of this gene belongs to the family of G-protein coupled receptors, which containsseveral receptor subtypes with different pharmacological selectivity for various adenosine anduridine nucleotides. This receptor is a P2Y purinergic receptor for UDP-glucose and otherUDP-sugars coupled to G-proteins. It has been implicated in extending the known immune systemfunctions of P2Y receptors by participating in the regulation of the stem cell compartment, and itmay also play a role in neuroimmune function. Two transcript variants encoding the same proteinhave been identified for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391 Function : Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP,ADP, UTP or ATP
Gene Wiki entry for P2RY14
Genomic Location for P2RY14
(According to
GeneLoc and/or
HGNC , and/or
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and/or miRBase ,
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Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the P2RY14 gene Entrez Gene cytogenetic band: 3q24-q25.1 Ensembl cytogenetic band: 3q25.1 HGNC cytogenetic band: 3q21-q25 P2RY14 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03M152412:
(about GC identifiers )
Start:
152,412,595 bp from pter
End:
152,478,920 bp from pter
Size:
66,326 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000003.10 NT_005612.15 Proteins for P2RY14
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391 (See
protein sequence )Recommended Name: P2Y purinoceptor 14 Size : 338 amino acids; 38971 Da
Subcellular location : Cell membrane; Multi-pass membrane protein
PDB structures from and Proteopedia : 2B6V (3D)
 
Secondary accessions : Q8IYT7
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001074924.1 NP_055694.3 ENSEMBL proteins: ENSP00000308361 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for P2RY14: Assays for P2RY14:
Protein
Domains/ Families for P2RY14(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q15391 ProtoNet protein and cluster: Q15391
1 Blocks protein family : IPB005466 UDP-glucose receptor signature UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391 Similarity : Belongs to the G-protein coupled receptor 1 family
Gene Function for P2RY14
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001081455 Applied Biosystems Silencer ® siRNAs for P2RY14 Sigma-Aldrich siRNA and siRNA Panels for P2RY14 Sigma-Aldrich shRNA Panels and shRNA for P2RY14 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001081455                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001081455                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001081455  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014879 UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391 Function : Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP,ADP, UTP or ATP
4 Gene Ontology (GO) molecular function terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0004872 receptor activity
IEA -- GO:0004930 G-protein coupled receptor activity
IEA -- GO:0045028 purinergic nucleotide receptor activity, G-protein coupled
IEA -- GO:0045029 UDP-activated nucleotide receptor activity
NAS 10753868
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Pathways & Interactions for P2RY14
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for P2RY14 3 Interacting proteins for P2RY14 (ENSP00000308361 3 ) via UniProtKB, MINT, and/or STRING About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
About this table
Drugs & Compounds for P2RY14 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Compounds for P2RY14 available from Tocris Bioscience About this table 3 Novoseek chemical compound relationships for P2RY14 gene
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Transcripts for P2RY14(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_001081455 Sigma-Aldrich siRNA and siRNA Panels for P2RY14 Sigma-Aldrich shRNA Panels and shRNA for P2RY14 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001081455 NM_014879
REFSEQ mRNAs for P2RY14 gene (2 alternative transcripts): NM_001081455.1 NM_014879.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001081455 NM_014879
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001081455                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001081455                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001081455  
Additional cDNA sequence: AK289617.1 BC034989.2 D13626.1 EF577400.1
4 DOTS entries : DT.308482 DT.100752507 DT.100752506 DT.92414697
24/30 AceView cDNA sequences (see all 30
):AI686699 AI167543 AI277229 BC034989 CB215819 BM783128 NM_014879 BX098156 BF594630 AA026830 CB992700 AU138895 CD110153 BG621304 D13626 BX500840 AA027011 AL598208 BG205036 BQ005549 AV759275 AV756028 BP345407 AU157802
highest scoring ESTs for P2RY14 :D13626 BC034989 BI459179 AA026830 AA027011 AI167543 AI277229 AI686699 AL598208 AU138895
Unigene Cluster for P2RY14: Purinergic receptor P2Y, G-protein coupled, 14 Hs.2465 [show with all ESTs ] Unigene Representative Sequence: NM_001081455 GeneLoc Exon Structure 1 Ensembl transcript including schematic representation : ENST00000309170
Expression for P2RY14
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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P2RY14 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for P2RY14 1 / 2 / 3
3 probe-sets matching P2RY14 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: CTTTACTGTCSOURCE GeneReport for Unigene cluster: Hs.2465 Expression variation in blood from EXPOLDB for P2RY14
UniProtKB/Swiss-Prot: P2Y14_HUMAN, Q15391 Tissue specificity : Highest expression in the placenta, adipose tissue, stomach and intestine,intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney
Orthologs for P2RY14
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for P2RY14 gene from 5/7 species (see all 7
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
dog (Canis familiaris)
P2RY141
--
purinergic receptor P2Y, G-protein coupled, 14
84.52(n) 83.73(a)
485717 XM_542838.2 XP_542838.2
chimpanzee (Pan troglodytes)
P2RY141
--
purinergic receptor P2Y, G-protein coupled, 14
98.82(n) 99.11(a)
738743 XM_001145005.1 XP_001145005.1
cow (Bos taurus)
P2RY141
--
purinergic receptor P2Y, G-protein coupled, 14
81.9(n) 79.23(a)
767936 NM_001077009.1 NP_001070477.1
rat (Rattus norvegicus)
P2ry141
--
purinergic receptor P2Y, G-protein coupled, 14
79.86(n) 80.55(a)
171108 NM_133577.1 NP_598261.1
mouse (Mus musculus)
P2ry141 , 5
3 (29.50 cM) 5
purinergic receptor P2Y, G-protein coupled, 141, 5
81.56(n) 1 83.14(a) 1
140795 1 NM_001008497.1 1 NP_001008497.1 1 AA139729 5 AF177211 5 (see all 12 )
About this table Species with no ortholog for P2RY14 ENSEMBL Gene Tree for P2RY14 Paralogs for P2RY14 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for P2RY14 gene GPR171 2 P2RY13 2 GPR87 2 P2RY12 2
SNPs/Variants for P2RY14 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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--
Disorders & Mutations for P2RY14
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 610116
Medical News for P2RY14 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for P2RY14 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/28 PubMed articles for P2RY14 gene (see all 28
): The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3. (PubMed id 11524702) 3, 4 Joensuu T.... Sankila E.-M. (2001) A G protein-coupled receptor for UDP-glucose. (PubMed id 10753868) 3, 4 Chambers J.K.... Livi G.P. (2000) Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. (PubMed id 7584026) 3, 4 Nomura N....Tabata S. (1994) GPR105, a novel Gi/o-coupled UDP-glucose receptor expressed on brain glia and peripheral immune cells, is regulated by immunologic challenge: possible role in neuroimmune function. (PubMed id 14559350) 1, 3 Moore D.J....Emson P.C. (2003) P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. (PubMed id 12842911) 1, 3 Lee B.C....Scadden D.T. (2003) Human immature monocyte-derived dendritic cells express the G protein-coupled receptor GPR105 (KIAA0001, P2Y14) and increase intracellular calcium in response to its agonist, uridine diphosphoglucose. (PubMed id 12902497) 1, 3 Skelton L....Platt A. (2003) The P2Y14 receptor of airway epithelial cells: coupling to intracellular Ca2+ and IL-8 secretion. (PubMed id 16109883) 1, 3 Muller T....Idzko M. (2005) Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. (PubMed id 12559763) 1, 3 Abbracchio M.P....Burnstock G. (2003) Creation of GPCR-based chemical sensors by directed evolution in yeast. (PubMed id 16263727) 1, 3 Ault A.D. and Broach J.R. (2006)
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Genome Databases showing P2RY14
(According to
Entrez Gene ,
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing P2RY14
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Specialized Databases showing P2RY14 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for P2RY14 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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