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P2RY13 Gene

protein-coding   GIFtS: 53

GC03M152526
purinergic receptor P2Y, G-protein coupled, 13
(Previous name: G protein-coupled receptor 86 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: GPR94, GPR86)
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Aliases &
Descriptions
for P2RY13

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
FKSG77 1, 2
GPCR1 2
GPR86 2, 3
GPR94 2, 3
P2Y13 1, 2, 3
SP174 2
Descriptions
G protein-coupled receptor 86 1, 2
G-protein coupled receptor 86 3
G-protein coupled receptor 94 2, 3
P2Y purinoceptor 13 2
purinergic receptor P2Y, G-protein coupled, 13 2
External Ids
HGNC: 45371
Entrez Gene: 538292
UniProtKB: Q9BPV83
Ensembl: ENSG000001816317
Search outside databases for aliases for P2RY13 gene

Summaries
for P2RY13

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for P2RY13:
The product of this gene belongs to the family of G-protein coupled receptors. This family has
several receptor subtypes with different pharmacological selectivity, which overlaps in some
cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. [provided
by RefSeq]

UniProtKB/Swiss-Prot: P2Y13_HUMAN, Q9BPV8
Function: Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the
immune system

Gene Wiki entry for P2RY13

Genomic Location
for P2RY13

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the P2RY13 gene  

Entrez Gene cytogenetic band: 3q24   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q24

P2RY13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M152526:     (about GC identifiers)

Start:
 152,526,786 bp from pter
End:
 152,530,025 bp from pter
Size:
 3,240 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000003.10  NT_005612.15  

Proteins
for P2RY13

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: P2Y13_HUMAN, Q9BPV8 (See protein sequence)
Recommended Name: P2Y purinoceptor 13  
Size: 354 amino acids; 40819 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Miscellaneous: Stimulation by ADP in stably transfected CHO cells resulted in inhibition of
adenylyl cyclase and the phosphorylation of the MAP kinases MAPK3 and MAPK1 in a pertussis
toxin-sensitive way. Inhibition of adenylyl cyclase and phosphorylation of the MAP kinases are
transduction mechanisms that involve G(i) proteins
Sequence caution: Sequence=AAH29363.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.
Potential poly-A sequence; Sequence=AAK18752.1; Type=Frameshift; Positions=172;
PDB structures from and Proteopedia :
2B6U (3D)    
Secondary accessions: B2R827 Q05C50 Q6DKN4 Q8IUT5 Q8TDU7 Q9BY61
Alternative splicing: 2 isoforms:  Q9BPV8-1   Q9BPV8-2   

REFSEQ proteins (2 alternative transcripts): 
NP_076403.2  NP_795713.2  


ENSEMBL proteins: 
ENSP00000320376 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (GPCR GPR86)
Human Recombinant Proteins from Abnova (P2RY13)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005783 endoplasmic reticulum IEA--
GO:0005886 plasma membrane IEA--
GO:0016021 integral to membrane NAS--
About this table

Antibodies for P2RY13: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of P2RY13
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Antibodies from Abcam (GPCR GPR86), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (P2RY13)
Novus Biologicals Antibodies for P2RY13

Assays for P2RY13: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for P2RY13

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_supfam
 IPR008109 P2Y13_purnocptor
 IPR000276 7TM_GPCR_Rhodpsn
 IPR002286 P2_purnocptor


   GeneDecks  P2RY13 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q9BPV8

ProtoNet protein and cluster: Q9BPV8

2 Blocks protein families:
IPB002286 P2 purinoceptor signature
IPB008109 P2Y13 purinoceptor signature


UniProtKB/Swiss-Prot: P2Y13_HUMAN, Q9BPV8
Similarity: Belongs to the G-protein coupled receptor 1 family

Gene Function
for P2RY13

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (P2RY13)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_176894

              Applied Biosystems Silencer® siRNAs for P2RY13

              Sigma-Aldrich siRNA and siRNA Panels for P2RY13  
                     Sigma-Aldrich shRNA Panels and shRNA for P2RY13  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for P2RY13
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_023914
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_023914
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_023914 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_176894

UniProtKB/Swiss-Prot: P2Y13_HUMAN, Q9BPV8
Function: Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the
immune system

1 MGI phenotypic allele for P2ry13 (no phenotypes)


3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004872 receptor activity IEA--
GO:0004930 G-protein coupled receptor activity IEA--
GO:0045028 purinergic nucleotide receptor activity, G-protein coupled IEA--
About this table

Pathways & Interactions
for P2RY13

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Millipore Pathway for P2RY13
 Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

   GeneDecks  P2RY13 for the pathways selected above  
About GeneDecksing

1 Kegg Pathway  (Kegg details for P2RY13):
 hsa04080 Neuroactive ligand-receptor interaction

   GeneDecks  P2RY13 for the pathways selected above  
About GeneDecksing

4 Interacting proteins for P2RY13 (ENSP000003203763) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
P2RX1ENSP000002255383STRING (score=.778)
P2RY11ENSP000003238723STRING (score=.774)
P2RX4ENSP000003366073STRING (score=.769)
P2RX7ENSP000002618263STRING (score=.73)
About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007165 signal transduction IEA--
GO:0007186 G-protein coupled receptor protein signaling pathway IEA--
GO:0008150 biological_process ND--
About this table

Drugs & Compounds
for P2RY13

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Sigma-Aldrich Small Molecules for P2RY13:
Antagonist Agonist

Compounds for P2RY13 available from Tocris Bioscience
CompoundAction CAS number
MRS 2211Competitive P2Y13 antagonist
Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
2-Methylthioadenosine triphosphate tetrasodium saltP2 purinergic agonist[43170-89-4]
PPADS tetrasodium saltP2 purinergic antagonist[149017-66-3]
2-Methylthio-ADP trisodium saltPotent agonist for P2Y1, P2Y12 and P2Y13[34983-48-7]
About this table


1 Novoseek chemical compound relationship for P2RY13 gene
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
adp 55.05 4 11961076 (3)
About this table


Transcripts
for P2RY13

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (P2RY13)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_176894

              Sigma-Aldrich siRNA and siRNA Panels for P2RY13  
                     Sigma-Aldrich shRNA Panels and shRNA for P2RY13  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_176894  

REFSEQ mRNAs for P2RY13 gene (2 alternative transcripts): 

NM_023914.2   NM_176894.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_176894  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_023914
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_023914
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_023914 

Additional cDNA sequence: 

AF178982.1 AF406692.1 AK313208.1 BC029363.1 BC041116.1 BC066887.1 

2 DOTS entries:

DT.70104099  DT.91656824 

24/30 AceView cDNA sequences (see all 30 ):

NM_176894 AI471697 AI129856 NM_023914 AI632090 AF406692 AF295368 AI289619 
BC066887 AI656746 BG621718 BP339057 AF178982 CD559649 AI655538 BC029363 
AF345565 BX111421 AI090920 T67106 BI489709 BC041116 AW295791 CD690381 

highest scoring ESTs for P2RY13:

AA142914 AI090920 BC029363 BC041116 BG621718 BI489709 AF178982 AF295368 AF345565 AF406692 

Unigene Cluster for P2RY13:

Purinergic receptor P2Y, G-protein coupled, 13
Hs.546396  [show with all ESTs]
Unigene Representative Sequence: BC041116


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000325602  

Expression
for P2RY13

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

P2RY13 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for P2RY13

1 / 2 / 3

4 probe-sets matching P2RY13 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
69431_at2, 3 U95-E 1 1.00 1.00 0.96 1.07 AI090920 0.80 1.00 0.91 1
46551_at2, 3 U95-B 1 0.56 1.00 0.97 0.94 AA142914 0.80 1.00 0.91 1

220005_at2, 3 U133-A 1 1.00 1.00 -- -- NM_023914 0.60 1.00 0.82 1

220005_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
GeneDecks  P2RY13 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AAATATTACC

SOURCE GeneReport for Unigene cluster: Hs.546396

UniProtKB/Swiss-Prot: P2Y13_HUMAN, Q9BPV8
Tissue specificity: Strong expression in spleen and adult brain. Lower expression in placenta,
lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and
adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta.
Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear
cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells
(PMN). In the brain, detected in all brain regions examined

Orthologs
for P2RY13

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for P2RY13 gene from 5/7 species (see all 7 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 P2RY131   -- purinergic receptor P2Y, G-protein coupled, 13 85.34(n)
84.64(a)		 609841  XM_847569.1  XP_852662.1 
chimpanzee
(Pan troglodytes)		 P2RY131   -- purinergic receptor P2Y, G-protein coupled, 13 99.4(n)
99.1(a)		 738859  XM_001145323.1  XP_001145323.1 
cow
(Bos taurus)		 P2RY131   -- purinergic receptor P2Y, G-protein coupled, 13 84.88(n)
82.28(a)		 782774  XM_001251103.1  XP_001251104.1 
rat
(Rattus norvegicus)		 P2ry131   -- purinergic receptor P2Y, G-protein coupled, 13 80.51(n)
80.61(a)		 310444  NM_001002853.1  NP_001002853.1 
mouse
(Mus musculus)		 P2ry131, 5 35
 purinergic receptor P2Y, G-protein coupled 131, 5 80.3(n)1
78.18(a)1		 741911  NM_028808.21  NP_083084.11 
 AK0080135  AK0385605  (see all 7)
About this table        Species with no ortholog for P2RY13

ENSEMBL Gene Tree for P2RY13

Paralogs
for P2RY13

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for P2RY13 gene
GPR1712  GPR872  P2RY142  P2RY122  

SNPs/Variants
for P2RY13

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

  --

Disorders & Mutations
for P2RY13

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 606380

Medical News
for P2RY13

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for P2RY13

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/13 PubMed articles for P2RY13 gene (see all 13 ):

Search for P2RY13

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing P2RY13

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 53829 HGNC: 4537 AceView: P2RY13 Ensembl:ENSG00000181631 euGenes: HUgn53829
ECgene: P2RY13 H-InvDB: P2RY13

Other Databases showing P2RY13

(According to HUGE)
About This Section

   --

Specialized Databases showing P2RY13

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for P2RY13

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for P2RY13

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for P2RY13:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for P2RY13-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for P2RY13 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for P2RY13 Small molecules for P2RY13
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Recombinant Proteins
(GPCR GPR86)
 Antibodies (GPCR GPR86)
 Search OriGene for P2RY13
 Tocris compounds for P2RY13




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for P2RY13

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