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Aliases for P2RY13 Gene

Aliases for P2RY13 Gene

  • Purinergic Receptor P2Y, G-Protein Coupled, 13 2 3
  • GPR86 3 4 6
  • G Protein-Coupled Receptor 86 2 3
  • G-Protein Coupled Receptor 86 3 4
  • G-Protein Coupled Receptor 94 3 4
  • GPR94 3 4
  • P2Y13 3 4
  • P2Y Purinoceptor 13 3
  • FKSG77 3
  • GPCR1 3
  • SP174 3

External Ids for P2RY13 Gene

Previous Symbols for P2RY13 Gene

  • GPR94
  • GPR86

Summaries for P2RY13 Gene

Entrez Gene Summary for P2RY13 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is activated by ADP. [provided by RefSeq, Sep 2008]

GeneCards Summary for P2RY13 Gene

P2RY13 (Purinergic Receptor P2Y, G-Protein Coupled, 13) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY14.

UniProtKB/Swiss-Prot for P2RY13 Gene

  • Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.

Tocris Summary for P2RY13 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10 receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4 receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13 and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They have diverse physiological roles including regulation of platelet aggregation, muscle contraction, neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY13 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY13 Gene

Genomics for P2RY13 Gene

Genomic Location for P2RY13 Gene

Start:
151,326,308 bp from pter
End:
151,329,549 bp from pter
Size:
3,242 bases
Orientation:
Minus strand

Genomic View for P2RY13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for P2RY13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY13 Gene

Regulatory Elements for P2RY13 Gene

Proteins for P2RY13 Gene

  • Protein details for P2RY13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BPV8-P2Y13_HUMAN
    Recommended name:
    P2Y purinoceptor 13
    Protein Accession:
    Q9BPV8
    Secondary Accessions:
    • B2R827
    • Q05C50
    • Q6DKN4
    • Q8IUT5
    • Q8TDU7
    • Q9BY61

    Protein attributes for P2RY13 Gene

    Size:
    354 amino acids
    Molecular mass:
    40789 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Stimulation by ADP in stably transfected CHO cells resulted in inhibition of adenylyl cyclase and the phosphorylation of the MAP kinases MAPK3 and MAPK1 in a pertussis toxin-sensitive way. Inhibition of adenylyl cyclase and phosphorylation of the MAP kinases are transduction mechanisms that involve G(i) proteins
    SequenceCaution:
    • Sequence=AAH29363.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH41116.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG36024.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for P2RY13 Gene

    Alternative splice isoforms for P2RY13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for P2RY13 Gene

Proteomics data for P2RY13 Gene at MOPED

Post-translational modifications for P2RY13 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn23, Asn31, and Asn285

Other Protein References for P2RY13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for P2RY13 Gene

Domains for P2RY13 Gene

Gene Families for P2RY13 Gene

HGNC:
  • P2R :Purinergic receptors
  • P2RY :GPCR / Class A : Purinergic receptors, P2Y
IUPHAR :

Protein Domains for P2RY13 Gene

UniProtKB/Swiss-Prot:

P2Y13_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q9BPV8
genes like me logo Genes that share domains with P2RY13: view

Function for P2RY13 Gene

Molecular function for P2RY13 Gene

UniProtKB/Swiss-Prot Function: Receptor for ADP. Coupled to G(i)-proteins. May play a role in hematopoiesis and the immune system.

Gene Ontology (GO) - Molecular Function for P2RY13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IBA --
genes like me logo Genes that share ontologies with P2RY13: view
genes like me logo Genes that share phenotypes with P2RY13: view

Animal Models for P2RY13 Gene

MGI Knock Outs for P2RY13:

miRNA for P2RY13 Gene

miRTarBase miRNAs that target P2RY13

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for P2RY13 Gene

Localization for P2RY13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY13 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY13 Gene COMPARTMENTS Subcellular localization image for P2RY13 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for P2RY13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with P2RY13: view

Pathways for P2RY13 Gene

genes like me logo Genes that share pathways with P2RY13: view

Interacting Proteins for P2RY13 Gene

Gene Ontology (GO) - Biological Process for P2RY13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IBA --
GO:0007194 negative regulation of adenylate cyclase activity IEA --
GO:0008150 biological_process ND --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with P2RY13: view

Compounds for P2RY13 Gene

(5) Tocris Compounds for P2RY13 Gene

Compound Action Cas Number
alpha,beta-Methyleneadenosine 5-triphosphate trisodium salt P2 agonist [7292-42-4]
MRS 2179 tetrasodium salt Selective P2Y1 antagonist [101204-49-3]
MRS 2365 Highly potent and selective P2Y1 agonist [436847-09-5]
MRS 2500 tetraammonium salt Extremely potent and selective P2Y1 antagonist [630103-23-0]
UTPgammaS trisodium salt Selective P2Y2/4 agonist [1266569-94-1]

(15) IUPHAR Ligand for P2RY13 Gene

Ligand Type Action Affinity Pubmed IDs
[33P]2MeSADP Agonist Full agonist 9.6
cangrelor Antagonist Antagonist 8.3
2MeSADP Agonist Full agonist 7
MRS2603 Antagonist Antagonist 6.18
Ap4A Agonist Full agonist 6.1
MRS2211 Antagonist Antagonist 5.97
ADP Gating inhibitor Antagonist 5.7
2MeSAMP Antagonist Antagonist 5.6
ATPgammaS Agonist Full agonist 5.5
reactive blue-2 Antagonist Antagonist 5
PPADS Antagonist Antagonist 5
ADPbetaS Agonist Full agonist 4.5
2MeSATP Agonist Full agonist 4.3
suramin Activator None
ATP Activator None

(1) Novoseek inferred chemical compound relationships for P2RY13 Gene

Compound -log(P) Hits PubMed IDs
adp 54.5 3
genes like me logo Genes that share compounds with P2RY13: view

Transcripts for P2RY13 Gene

mRNA/cDNA for P2RY13 Gene

Unigene Clusters for P2RY13 Gene

Purinergic receptor P2Y, G-protein coupled, 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY13 Gene

No ASD Table

Relevant External Links for P2RY13 Gene

GeneLoc Exon Structure for
P2RY13
ECgene alternative splicing isoforms for
P2RY13

Expression for P2RY13 Gene

mRNA expression in normal human tissues for P2RY13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY13 Gene

This gene is overexpressed in Whole Blood (39.2) and Spleen (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for P2RY13 Gene

SOURCE GeneReport for Unigene cluster for P2RY13 Gene Hs.546396

mRNA Expression by UniProt/SwissProt for P2RY13 Gene

Q9BPV8-P2Y13_HUMAN
Tissue specificity: Strong expression in spleen and adult brain. Lower expression in placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. Not detected in pancreas, heart, kidney, skeletal muscle, ovary or fetal aorta. Clearly detected in lymph node and bone marrow, weakly detected in peripheral blood mononuclear cells (PBMC) and in peripheral blood leukocytes (PBL), but not detected in polymorphonuclear cells (PMN). In the brain, detected in all brain regions examined
genes like me logo Genes that share expressions with P2RY13: view

Orthologs for P2RY13 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY13 36
  • 99.44 (n)
  • 99.15 (a)
P2RY13 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia P2RY13 36
  • 84.88 (n)
  • 82.28 (a)
P2RY13 37
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY13 36
  • 85.19 (n)
  • 84.38 (a)
P2RY13 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia P2ry13 36
  • 80.04 (n)
  • 77.84 (a)
P2ry13 16
P2ry13 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia P2RY13 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia P2RY13 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2ry13 36
  • 80.04 (n)
  • 79.94 (a)
chicken
(Gallus gallus)
Aves LOC101749756 36
  • 65.44 (n)
  • 61.77 (a)
P2RY13 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia P2RY13 37
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry13 36
  • 58.72 (n)
  • 54.65 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100329592 36
  • 53.63 (n)
  • 48.9 (a)
p2ry13 37
  • 46 (a)
OneToOne
Species with no ortholog for P2RY13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY13 Gene

ENSEMBL:
Gene Tree for P2RY13 (if available)
TreeFam:
Gene Tree for P2RY13 (if available)

Paralogs for P2RY13 Gene

Paralogs for P2RY13 Gene

Selected SIMAP similar genes for P2RY13 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with P2RY13: view

Variants for P2RY13 Gene

Sequence variations from dbSNP and Humsavar for P2RY13 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
VAR_028299 -

Structural Variations from Database of Genomic Variants (DGV) for P2RY13 Gene

Variant ID Type Subtype PubMed ID
nsv829757 CNV Loss 17160897

Relevant External Links for P2RY13 Gene

HapMap Linkage Disequilibrium report
P2RY13

Disorders for P2RY13 Gene

Relevant External Links for P2RY13

Genetic Association Database (GAD)
P2RY13
Human Genome Epidemiology (HuGE) Navigator
P2RY13
genes like me logo Genes that share disorders with P2RY13: view

No data available for UniProtKB/Swiss-Prot for P2RY13 Gene

Publications for P2RY13 Gene

  1. An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. (PMID: 11273702) Wittenberger T. … Hellebrand S. (J. Mol. Biol. 2001) 2 3 4 23
  2. Discovery and mapping of ten novel G protein-coupled receptor genes. (PMID: 11574155) Lee D.K. … O'Dowd B.F. (Gene 2001) 2 3 4
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4
  4. P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse. (PMID: 11961076) Zhang F.L. … Monsma F. (J. Pharmacol. Exp. Ther. 2002) 3 23
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 49

Products for P2RY13 Gene

Sources for P2RY13 Gene

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