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P2RY12 Gene

protein-coding   GIFtS: 62
GCID: GC03M151055

Purinergic Receptor P2Y, G-Protein Coupled, 12

  See P2RY12-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Purinergic Receptor P2Y, G-Protein Coupled, 121 2     ADP-Glucose Receptor2 3
P2Y122 3 5     P2Y12 Platelet ADP Receptor2 3
ADPG-R2 3     BDPLT82 5
HORK32 3     P2Y(12)R2
P2T(AC)2 3     G-Protein Coupled Receptor SP19992
P2Y(AC)2 3     Gi-Coupled ADP Receptor HORK32
P2Y(ADP)2 3     P2Y Purinoceptor 122
P2Y(cyc)2 3     Purinergic Receptor P2RY122
SP19992 3     Putative G-Protein Coupled Receptor2

External Ids:    HGNC: 181241   Entrez Gene: 648052   Ensembl: ENSG000001693137   OMIM: 6005155   UniProtKB: Q9H2443   

Export aliases for P2RY12 gene to outside databases

Previous GC identifers: GC03M147996 GC03M151887 GC03M152336 GC03M152376 GC03M152538 GC03M148428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for P2RY12 Gene:
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor
subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and
uridine nucleotides. This receptor is involved in platelet aggregation, and is a potential target for the
treatment of thromboembolisms and other clotting disorders. Mutations in this gene are implicated in bleeding
disorder, platelet type 8 (BDPLT8). Alternative splicing results in multiple transcript variants of this gene.
(provided by RefSeq, Jul 2013)

GeneCards Summary for P2RY12 Gene:
P2RY12 (purinergic receptor P2Y, G-protein coupled, 12) is a protein-coding gene. Diseases associated with P2RY12 include bleeding disorder, platelet-type, 8, and type 1 von willebrand disease. GO annotations related to this gene include ADP receptor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is GPR82.

UniProtKB/Swiss-Prot: P2Y12_HUMAN, Q9H244
Function: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger
system. Not activated by UDP and UTP. Involved in platelet aggregation

summary for P2RY12 Gene:
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine
nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13
and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10
receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4
receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13
and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades
including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They
have diverse physiological roles including regulation of platelet aggregation, muscle contraction,
neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY12 (P2Y12) Gene

PharmGKB "VIP" summary for P2RY12


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the P2RY12 gene promoter:
         AhR   Pax-2   Pax-2a   POU3F2   LCR-F1   Arnt   PPAR-alpha   HFH-1   FOXO1a   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): P2RY12 promoter sequence
   Search Chromatin IP Primers for P2RY12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat P2RY12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q24-q25   Ensembl cytogenetic band:  3q25.1   HGNC cytogenetic band: 3q24-q25

P2RY12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P2RY12 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M151055:  view genomic region     (about GC identifiers)

Start:
151,055,168 bp from pter      End:
151,102,600 bp from pter
Size:
47,433 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: P2Y12_HUMAN, Q9H244 (See protein sequence)
Recommended Name: P2Y purinoceptor 12  
Size: 342 amino acids; 39439 Da
3 PDB 3D structures from and Proteopedia for P2RY12:
1T78 (3D)        1VZ1 (3D)        1Y9C (3D)    
Secondary accessions: D3DNJ5 Q546J7

Explore the universe of human proteins at neXtProt for P2RY12: NX_Q9H244

Explore proteomics data for P2RY12 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn6, Asn13
  • Modification sites at PhosphoSitePlus

  • See P2RY12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_073625.1  NP_795345.1  

    ENSEMBL proteins: 
     ENSP00000307259  
    Reactome Protein details: Q9H244

    P2RY12 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    P2R: Purinergic receptors
    P2RY: GPCR / Class A : Purinergic receptors, P2Y

    IUPHAR Guide to PHARMACOLOGY protein family classification: P2Y12 receptor
    P2Y receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR005394 P2Y12_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q9H244

    ProtoNet protein and cluster: Q9H244

    1 Blocks protein domain: IPB005394 P2Y12 purinoceptor signature

    UniProtKB/Swiss-Prot: P2Y12_HUMAN, Q9H244
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with P2RY12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P2Y12_HUMAN, Q9H244
    Function: Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger
    system. Not activated by UDP and UTP. Involved in platelet aggregation

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001609G-protein coupled adenosine receptor activity IEA--
    GO:0001621ADP receptor activity IEA--
    GO:0004930G-protein coupled receptor activity ----
    GO:0005085guanyl-nucleotide exchange factor activity TAS--
         
    Find genes that share ontologies with P2RY12           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for P2RY12:
     Decreased POU5F1-GFP protein e  Decreased influenza A/WSN/33 r  Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for P2ry12):
     hematopoietic system  homeostasis/metabolism  normal 

    Find genes that share phenotypes with P2RY12           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for P2RY12: P2ry12tm1Pcon P2ry12tm1Cjf

       genOway: Develop your customized and physiologically relevant rodent model for P2RY12

    miRNA
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    Inhib. RNA
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    Browse Sino Biological Human cDNA Clones
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P2Y12_HUMAN, Q9H244: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005901caveola IEA--
    GO:0009897external side of plasma membrane IEA--
    GO:0009925basal plasma membrane IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with P2RY12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for P2RY12 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71
    GPCRs, Class A Rhodopsin-like0.43
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3ADP signalling through P2Y purinoceptor 12
    Signal amplification0.79
    ADP signalling through P2Y purinoceptor 120.74
    4Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    5Nucleotide-like (purinergic) receptors
    Nucleotide-like (purinergic) receptors
    P2Y receptors0.00


    Find genes that share SuperPaths with P2RY12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for P2RY12
        P2Y Receptor Signaling

    1 BioSystems Pathway for P2RY12
        GPCRs, Class A Rhodopsin-like

    3 Reactome Pathways for P2RY12
        P2Y receptors
    G alpha (i) signalling events
    ADP signalling through P2Y purinoceptor 12

    2 PharmGKB Pathways for P2RY12
        Clopidogrel Pathway, Pharmacokinetics
    Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY12: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for P2RY12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for P2RY12 (Q9H2443 ENSP000003072594) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GNAI2P048993, ENSP000003129994I2D: score=1 STRING: ENSP00000312999
    ACKR3ENSP000002729284STRING: ENSP00000272928
    ADCY2ENSP000003429524STRING: ENSP00000342952
    ADCY6ENSP000003114054STRING: ENSP00000311405
    ADCY9ENSP000002940164STRING: ENSP00000294016
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 16):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001973adenosine receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway IEA--
    GO:0007596blood coagulation TAS--
    GO:0007599hemostasis NAS11196645

    Find genes that share ontologies with P2RY12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for P2RY12 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MRS 2365Highly potent and selective P2Y1 agonist[436847-09-5]
    alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist[7292-42-4]
    UTPgammaS trisodium saltSelective P2Y2/4 agonist[1266569-94-1]
    MRS 2500 tetraammonium saltExtremely potent and selective P2Y1 antagonist[630103-23-0]
    MRS 2179 tetrasodium saltSelective P2Y1 antagonist[101204-49-3]

    2 HMDB Compounds for P2RY12    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Clopidogrel(+)-(S)-Clopidogrel (see all 6)113665-84-2--

    6 DrugBank Compounds for P2RY12    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Clopidogrel-- 113665-84-2targetantagonist15199474 12615691 15308557 15269827 19463375 11752352 16835302 14668029 15291969
    Ticlopidine4-C-32 (see all 2)55142-85-3targetantagonist15816504 11752352 11454254 17110146 15955565
    EpoprostenolPGI2 (see all 3)35121-78-9targetagonist12297509 17155953 20085435
    Treprostinil-- 81846-19-7targetagonist17139284 17016423
    PrasugrelCS-747 (see all 2)150322-43-3targetantagonist18485086
    Ticagrelor-- 274693-27-5targetinhibitor--

    Selected IUPHAR Ligands for P2RY12 (P2Y12 receptor) (see all 24)    About this table
    LigandTypeActionAffinityPubmed IDs
    PSB-0739
    AntagonistAntagonist9.819690189
    [3H]2MeSADP
    AgonistFull agonist7.5 - 9.611502873
    2MeSADP
    AgonistFull agonist9.215199474
    2MeSATP
    AgonistFull agonist8.715199474
    ADPbetaS
    AgonistFull agonist8.611502873
    [3H]PSB-0413
    AntagonistAntagonist8.522892887
    AR-C67085
    AntagonistAntagonist8.223495690
    compound 20o [PMID:22984835]
    AntagonistAntagonist8.122984835
    cangrelor
    AntagonistAntagonist811502873
    ARL66096
    AntagonistAntagonist7.957582510 7858849

    Selected Novoseek inferred chemical compound relationships for P2RY12 gene (see all 35)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cangrelor 96.5 26 20126830 (3), 19485932 (2), 20465804 (2), 15668190 (1) (see all 21)
    clopidogrel 94.4 90 16769602 (4), 19550317 (4), 20465804 (3), 17214996 (2) (see all 58)
    prasugrel 93.9 15 16754711 (1), 16769599 (1), 18506123 (1), 20050853 (1) (see all 15)
    2-mesadp 91.8 10 11502873 (3), 15345752 (2), 18404433 (1), 16268477 (1) (see all 6)
    adp 91.1 197 14644082 (6), 11502873 (4), 16236603 (4), 11422381 (3) (see all 99)
    mrs2179 90.9 7 14644082 (1), 15604418 (1), 18404433 (1), 18480058 (1) (see all 7)
    3'-phosphoadenosine 5'-phosphate 83.1 6 15203713 (1), 11422381 (1), 12588350 (1), 12871420 (1)
    aspirin 78.6 47 20465804 (5), 14597584 (3), 15668190 (2), 16236601 (2) (see all 23)
    ticlopidine 78.5 8 11413167 (1), 14610915 (1), 11722284 (1), 19334620 (1) (see all 7)
    convulxin 76.2 1 18574670 (1)

    4 PharmGKB related drug/compound annotations for P2RY12 gene    About this table
    Drug/compound PharmGKB Annotation
    cangrelorCA  
    clopidogrelCA  
    prasugrel
    ticagrelor



    Find genes that share compounds with P2RY12           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for P2RY12 gene (2 alternative transcripts): 
    NM_022788.4  NM_176876.2  

    Unigene Cluster for P2RY12:

    Purinergic receptor P2Y, G-protein coupled, 12
    Hs.591281  [show with all ESTs]
    Unigene Representative Sequence: AK292096
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302632(uc011boa.2 uc003eyw.1 uc003eyx.1) ENST00000468596

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      QuantiTect SYBR Green Assays in human, mouse, rat P2RY12
      QuantiFast Probe-based Assays in human, mouse, rat P2RY12

    Additional mRNA sequence: 

    AB052684.1 AF313449.1 AF321815.1 AJ320495.1 AK292096.1 AK303714.1 AK316575.1 AY136754.1 
    BC017898.1 

    3 DOTS entries:

    DT.92036952  DT.95366404  DT.101973036 

    Selected AceView cDNA sequences (see all 28):

    AY136754 NM_176876 NM_022788 AB052684 BM713326 AJ320495 AF313449 BC017898 
    AW976204 AF321815 BI754688 AW015793 AI684536 BI758761 AA810452 CF147831 
    BQ893760 AL038524 BG716155 BX488128 AI307773 BG708321 AI829607 AW118661 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    P2RY12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAATAGTAAA
    P2RY12 Expression
    About this image


    P2RY12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Blood (Cardiovascular System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Lateral Plate Mesoderm (Gastrulation Derivatives)
             Hematopoietic Stem Cells Aorta-Gonad-Mesonephros
    P2RY12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    P2RY12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591281

    UniProtKB/Swiss-Prot: P2Y12_HUMAN, Q9H244
    Tissue specificity: Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung,
    appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain

        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY12: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for P2RY12 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia P2ry121 , 5 purinergic receptor P2Y, G-protein coupled 121, 5 83.13(n)1
    88.99(a)1
      3 (29.01 cM)5
    708391  NM_027571.31  NP_081847.31 
     592162715 
    chicken
    (Gallus gallus)
    Aves P2RY126
    purinergic receptor P2Y, G-protein coupled, 12
    70(a)
    1 ↔ 1
    9(22992557-22993576)
    lizard
    (Anolis carolinensis)
    Reptilia P2RY126
    purinergic receptor P2Y, G-protein coupled, 12
    72(a)
    1 ↔ 1
    3(18046654-18047589)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia p2ry121 purinergic receptor P2Y, G-protein coupled, 12 65.37(n)
    64.56(a)
      100493410  XM_002941103.1  XP_002941149.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1001496181 P2Y purinoceptor 12-like 59.02(n)
    58.69(a)
      100149618  XM_001921929.4  XP_001921964.1 


    ENSEMBL Gene Tree for P2RY12 (if available)
    TreeFam Gene Tree for P2RY12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for P2RY12 gene
    GPR822  P2RY132  GPR1712  GPR872  GPR342  P2RY142  
    12 SIMAP similar genes for P2RY12 using alignment to 1 protein entry:     P2Y12_HUMAN:
    P2RY13    P2RY14    GPR87    GPR171    GPR34    LPAR6
    PTAFR    GPR183    GPR68    LPAR4    CYSLTR2    KPG_011

    Find genes that share paralogs with P2RY12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    3 SNPs for P2RY12    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0253834
    Bleeding disorder, platelet-type 8 (BDPLT8)4--see VAR_0253832 R Q mis40--------
    VAR_0253844
    Bleeding disorder, platelet-type 8 (BDPLT8)4--see VAR_0253842 R W mis40--------
    rs168466731,2,4
    ----see VAR_0494312 mis40--------

    HapMap Linkage Disequilibrium report for P2RY12 (151055168 - 151102600 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for P2RY12:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2726057CNV Deletion23290073
    esv2400186CNV Deletion18987734
    esv2726056CNV Deletion23290073
    esv1169457CNV Deletion17803354
    nsv829757CNV Loss17160897

    Human Gene Mutation Database (HGMD): P2RY12
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing P2RY12
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600515   
    OMIM disorders: 609821  
    UniProtKB/Swiss-Prot: P2Y12_HUMAN, Q9H244
  • Bleeding disorder, platelet-type 8 (BDPLT8) [MIM:609821]: A condition characterized by mild to moderate
    mucocutaneous bleeding, and excessive bleeding after surgery or trauma. The defect is due to severe impairment of
    platelet response to ADP resulting in defective platelet aggregation. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 6 diseases for P2RY12:    
    About MalaCards
    bleeding disorder, platelet-type, 8    type 1 von willebrand disease    peripheral artery disease    angina pectoris
    coronary thrombosis    coronary artery disease


    Find genes that share disorders with P2RY12           About GenesLikeMe

    Selected Novoseek inferred disease relationships for P2RY12 gene (see all 14)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    thrombosis 60.1 10 19476973 (2), 14597584 (2), 19660606 (1), 10960076 (1) (see all 5)
    bleeding 44.5 7 20446120 (1), 19474710 (1), 20094648 (1), 17311506 (1) (see all 6)
    myocardial infarction 43 2 19334620 (1), 17707382 (1)
    coronary artery disease 38 6 20031628 (1), 17995973 (1), 15795539 (1), 17803810 (1) (see all 6)
    bleeding tendency 35 3 19237732 (1), 16194207 (1)
    cardiovascular diseases 29.1 4 19334620 (2), 12913786 (1), 19050170 (1)
    stroke 22.2 3 17707382 (2), 20210760 (1)
    glioma 18.8 4 11904146 (2), 11502873 (1), 14718252 (1)
    atherosclerosis 17.1 2 14662702 (1), 16476694 (1)
    vascular diseases 11.6 1 17707382 (1)

    Genetic Association Database (GAD): P2RY12
    Human Genome Epidemiology (HuGE) Navigator: P2RY12 (43 documents)

    Export disorders for P2RY12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for P2RY12 gene, integrated from 10 sources (see all 346):
    (articles sorted by number of sources associating them with P2RY12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y1 receptor. (PubMed id 11502873)1, 2, 3, 9 Takasaki J.... Furuichi K. (Mol. Pharmacol. 2001)
    2. ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999. (PubMed id 11104774)1, 2, 3 Zhang F.L....Monsma F.J. Jr. (J. Biol. Chem. 2001)
    3. [Genetic variants of platelet ADP receptor P2Y12 associated with changed platelet functional activity and development of cardiovascular diseases]. (PubMed id 19334620)1, 4, 9 Sirotkina O.V....Shvartsman A.L. (Genetika 2009)
    4. Coexisting polymorphisms of P2Y12 and CYP2C19 genes as a risk factor for persistent platelet activation with clopidogrel. (PubMed id 18577829)1, 4, 9 Malek L.A....Opolski G. (Circ. J. 2008)
    5. Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism. (PubMed id 17707382)1, 4, 9 Zee R.Y....Ridker P.M. (Atherosclerosis 2008)
    6. Platelet receptor P2RY12 haplotypes predict restenosis after percutaneous coronary interventions. (PubMed id 18175333)1, 4, 9 Rudez G....de Maat M. (Hum. Mutat. 2008)
    7. Common sequence variations in the P2Y12 and CYP3A5 genes do not explain the variability in the inhibitory effects of clopidogrel therapy. (PubMed id 16769602)1, 4, 9 Smith S.M....Storey R.F. (Platelets 2006)
    8. Common variation in the platelet receptor P2RY12 gene is associated with residual on-clopidogrel platelet reactivity in patients undergoing elective percutaneous coronary interventions. (PubMed id 20031628)1, 4, 9 Rudez G....Hackeng C.M. (Circ Cardiovasc Genet 2009)
    9. P2Y12 gene H2 haplotype is not associated with increased adenosine diphosphate-induced platelet aggregation after initiation of clopidogrel therapy with a high loading dose. (PubMed id 15795539)1, 4, 9 von Beckerath N....Kastrati A. (amp 2005)
    10. Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP. (PubMed id 15514209)1, 4, 9 Hetherington S.L....Samani N.J. (Arterioscler. Thromb. Vasc. Biol. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64805 HGNC: 18124 AceView: P2RY12 Ensembl:ENSG00000169313 euGenes: HUgn64805
    ECgene: P2RY12 H-InvDB: P2RY12

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for P2RY12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for P2RY12 gene:
    Search GeneIP for patents involving P2RY12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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