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Aliases for P2RY11 Gene

Aliases for P2RY11 Gene

  • Purinergic Receptor P2Y11 2 3 5
  • Purinergic Receptor P2Y, G-Protein Coupled, 11 2 3
  • P2Y11 3 4
  • P2Y Purinoceptor 11 3

External Ids for P2RY11 Gene

Previous GeneCards Identifiers for P2RY11 Gene

  • GC19P010343
  • GC19P010445
  • GC19P010068
  • GC19P010083
  • GC19P010222
  • GC19P009823
  • GC19P010113
  • GC19P010116
  • GC19P010117
  • GC19P010119

Summaries for P2RY11 Gene

Entrez Gene Summary for P2RY11 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY11 Gene

P2RY11 (Purinergic Receptor P2Y11) is a Protein Coding gene. Diseases associated with P2RY11 include Narcolepsy. Among its related pathways are Signaling by GPCR and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY1.

UniProtKB/Swiss-Prot for P2RY11 Gene

  • Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.

Tocris Summary for P2RY11 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY11 Gene

Genomics for P2RY11 Gene

Regulatory Elements for P2RY11 Gene

Enhancers for P2RY11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F010100 1.5 FANTOM5 ENCODE 12.2 -7.1 -7134 8.3 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A YBX1 DMAP1 FBXL12 ZNF699 ZNF561 LOC100419831 ZNF559 TIMM29 YIPF2 ZNF562 EIF3G ZNF121
GH19F010109 1.3 Ensembl ENCODE 13.6 +2.2 2176 8.8 HDGF PKNOX1 WRNIP1 SIN3A ZNF48 ZNF121 GLIS2 ZNF416 ZNF143 FOS P2RY11 TIMM29 C19orf66 ZNF121 ZNF426 KEAP1 EIF3G MRPL4 GC19P010126
GH19F010141 1.1 Ensembl ENCODE 12.5 +31.6 31587 2.2 CREB3L1 NFRKB ZNF48 ZNF335 ZNF121 ZNF766 PAF1 SMARCA5 MIER1 ZBTB11 C19orf66 ANGPTL6 EIF3G P2RY11 SNORD105B PPAN PPAN-P2RY11 SNORD105 RDH8 COL5A3
GH19F010118 1.4 Ensembl ENCODE 9.5 +9.4 9372 4.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF561 FBXL12 LOC100419831 ZNF699 S1PR2 ZNF559 ZNF846 P2RY11 KEAP1 EIF3G
GH19F010197 1 Ensembl ENCODE 11.4 +88.2 88187 4.2 HDGF KLF1 ZMYM3 ZNF384 ZNF316 NFE2 MAFK SCRT1 ZNF362 L3MBTL2 C19orf66 ANGPTL6 S1PR2 MRPL4 ICAM1 EIF3G P2RY11 SNORD105B PPAN PPAN-P2RY11
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around P2RY11 on UCSC Golden Path with GeneCards custom track

Genomic Location for P2RY11 Gene

Chromosome:
19
Start:
10,111,521 bp from pter
End:
10,115,389 bp from pter
Size:
3,869 bases
Orientation:
Plus strand

Genomic View for P2RY11 Gene

Genes around P2RY11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY11 Gene

Proteins for P2RY11 Gene

  • Protein details for P2RY11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G91-P2Y11_HUMAN
    Recommended name:
    P2Y purinoceptor 11
    Protein Accession:
    Q96G91
    Secondary Accessions:
    • B2R8X9
    • O43190
    • Q9BYU4
    • Q9H170

    Protein attributes for P2RY11 Gene

    Size:
    374 amino acids
    Molecular mass:
    40345 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528).
    SequenceCaution:
    • Sequence=AAB88674.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC18877.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for P2RY11 Gene

neXtProt entry for P2RY11 Gene

Post-translational modifications for P2RY11 Gene

  • Glycosylation at Asn 4 and Asn 179
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for P2RY11 (P2Y11/P2RY11)
  • Abcam antibodies for P2RY11

No data available for DME Specific Peptides for P2RY11 Gene

Domains & Families for P2RY11 Gene

Gene Families for P2RY11 Gene

Protein Domains for P2RY11 Gene

Suggested Antigen Peptide Sequences for P2RY11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G91

UniProtKB/Swiss-Prot:

P2Y11_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY11: view

Function for P2RY11 Gene

Molecular function for P2RY11 Gene

UniProtKB/Swiss-Prot Function:
Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.
UniProtKB/Swiss-Prot Induction:
Increased by DMSO and retinoic acid.

Gene Ontology (GO) - Molecular Function for P2RY11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0004872 receptor activity TAS 9405388
GO:0004930 G-protein coupled receptor activity IEA --
GO:0030594 neurotransmitter receptor activity IDA 18048695
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY11: view
genes like me logo Genes that share phenotypes with P2RY11: view

Human Phenotype Ontology for P2RY11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

miRNA for P2RY11 Gene

miRTarBase miRNAs that target P2RY11

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for P2RY11 Gene

Localization for P2RY11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY11 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for P2RY11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC,TAS 18048695
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with P2RY11: view

Pathways & Interactions for P2RY11 Gene

genes like me logo Genes that share pathways with P2RY11: view

Pathways by source for P2RY11 Gene

Interacting Proteins for P2RY11 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000323872%0d%0a9606.ENSP00000262225%0d%0a
Selected Interacting proteins: ENSP00000323872 Q96G91-P2Y11_HUMAN for P2RY11 Gene via STRING IID

Gene Ontology (GO) - Biological Process for P2RY11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0006952 defense response TAS 9405388
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IDA 18048695
GO:0007190 activation of adenylate cyclase activity TAS 9405388
genes like me logo Genes that share ontologies with P2RY11: view

No data available for SIGNOR curated interactions for P2RY11 Gene

Drugs & Compounds for P2RY11 Gene

(21) Drugs for P2RY11 Gene - From: DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Suramin Approved Pharma Antagonist, antagonist 18
Uridine triphosphate Experimental Pharma 0
MC-1 Investigational Pharma 0
ATP Pharma Agonist 0
BzATP Pharma Full agonist, Agonist 0

(9) Additional Compounds for P2RY11 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ATPgammaS
Partial agonist, Agonist
Adpbetas
Agonist
UTP
Full agonist, Agonist
AR-C 118925XX
216657-60-2
PPTN hydrochloride

(5) Tocris Compounds for P2RY11 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
AR-C 118925XX Selective, competitive P2Y2 receptor antagonist 216657-60-2
MRS 2500 tetraammonium salt Extremely potent and selective P2Y1 antagonist 630103-23-0
PPTN hydrochloride High affinity and selective P2Y14 antagonist
SAR 216471 hydrochloride Potent P2Y12 antagonist; orally available 1279829-64-9
genes like me logo Genes that share compounds with P2RY11: view

Transcripts for P2RY11 Gene

mRNA/cDNA for P2RY11 Gene

Unigene Clusters for P2RY11 Gene

Purinergic receptor P2Y, G-protein coupled, 11:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY11 Gene

No ASD Table

Relevant External Links for P2RY11 Gene

GeneLoc Exon Structure for
P2RY11
ECgene alternative splicing isoforms for
P2RY11

Expression for P2RY11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for P2RY11 Gene

Protein differential expression in normal tissues from HIPED for P2RY11 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for P2RY11 Gene



Protein tissue co-expression partners for P2RY11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of P2RY11 Gene:

P2RY11

SOURCE GeneReport for Unigene cluster for P2RY11 Gene:

Hs.14468

mRNA Expression by UniProt/SwissProt for P2RY11 Gene:

Q96G91-P2Y11_HUMAN
Tissue specificity: Highest expression in liver and spleen.
genes like me logo Genes that share expression patterns with P2RY11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for P2RY11 Gene

Orthologs for P2RY11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for P2RY11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY11 34 35
  • 98.57 (n)
dog
(Canis familiaris)
Mammalia P2RY11 34
  • 79.41 (n)
cow
(Bos Taurus)
Mammalia P2RY11 34 35
  • 78.62 (n)
oppossum
(Monodelphis domestica)
Mammalia P2RY11 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry11 34
  • 55.52 (n)
zebrafish
(Danio rerio)
Actinopterygii p2ry11 34
  • 51.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta ppan 35
  • 8 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lpd-6 35
  • 5 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSF1 35
  • 8 (a)
ManyToMany
SSF2 35
  • 7 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2660 35
  • 8 (a)
OneToMany
Species where no ortholog for P2RY11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for P2RY11 Gene

ENSEMBL:
Gene Tree for P2RY11 (if available)
TreeFam:
Gene Tree for P2RY11 (if available)

Paralogs for P2RY11 Gene

(1) SIMAP similar genes for P2RY11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with P2RY11: view

Variants for P2RY11 Gene

Sequence variations from dbSNP and Humsavar for P2RY11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12460842 other 10,111,519(+) GTCAC(A/G)CTTTC intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs2305795 other 10,115,376(+) CAGCC(A/G)GGGGA intron-variant, utr-variant-3-prime
rs1037686 -- 10,112,159(+) TGTGA(A/T)TCCAG intron-variant
rs10408932 -- 10,112,623(+) ACGGA(C/T)GTGGG intron-variant
rs10409569 -- 10,112,612(+) CAGGC(A/G)GGACC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for P2RY11 Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV loss 17160897

Variation tolerance for P2RY11 Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RY11 Gene

Human Gene Mutation Database (HGMD)
P2RY11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
P2RY11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY11 Gene

Disorders for P2RY11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for P2RY11 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
narcolepsy
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for P2RY11

Genetic Association Database (GAD)
P2RY11
Human Genome Epidemiology (HuGE) Navigator
P2RY11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
P2RY11
genes like me logo Genes that share disorders with P2RY11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RY11 Gene

Publications for P2RY11 Gene

  1. Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. (PMID: 9405388) Communi D. … Boeynaems J.-M. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y11. (PMID: 17135283) Amisten S. … Erlinge D. (Eur. Heart J. 2007) 3 22 46 64
  3. Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes. (PMID: 11278528) Communi D. … Boeynaems J.-M. (J. Biol. Chem. 2001) 3 4 22 64
  4. Common variants in P2RY11 are associated with narcolepsy. (PMID: 21170044) Kornum B.R. … Mignot E. (Nat. Genet. 2011) 3 46 64
  5. NAADP+ is an agonist of the human P2Y11 purinergic receptor. (PMID: 17707504) Moreschi I. … De Flora A. (Cell Calcium 2008) 3 22 64

Products for P2RY11 Gene

Sources for P2RY11 Gene

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