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Aliases for P2RY11 Gene

Aliases for P2RY11 Gene

  • Purinergic Receptor P2Y11 2 3
  • Purinergic Receptor P2Y, G-Protein Coupled, 11 2 3 5
  • P2Y11 3 4

External Ids for P2RY11 Gene

Previous GeneCards Identifiers for P2RY11 Gene

  • GC19P010343
  • GC19P010445
  • GC19P010068
  • GC19P010083
  • GC19P010222
  • GC19P009823
  • GC19P010113
  • GC19P010116

Summaries for P2RY11 Gene

Entrez Gene Summary for P2RY11 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY11 Gene

P2RY11 (Purinergic Receptor P2Y11) is a Protein Coding gene. Diseases associated with P2RY11 include narcolepsy. Among its related pathways are Signaling by GPCR and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity.

UniProtKB/Swiss-Prot for P2RY11 Gene

  • Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.

Tocris Summary for P2RY11 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY11 Gene

Genomics for P2RY11 Gene

Regulatory Elements for P2RY11 Gene

Promoters for P2RY11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around P2RY11 on UCSC Golden Path with GeneCards custom track

Genomic Location for P2RY11 Gene

Chromosome:
19
Start:
10,111,521 bp from pter
End:
10,115,389 bp from pter
Size:
3,869 bases
Orientation:
Plus strand

Genomic View for P2RY11 Gene

Genes around P2RY11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY11 Gene

Proteins for P2RY11 Gene

  • Protein details for P2RY11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G91-P2Y11_HUMAN
    Recommended name:
    P2Y purinoceptor 11
    Protein Accession:
    Q96G91
    Secondary Accessions:
    • B2R8X9
    • O43190
    • Q9BYU4
    • Q9H170

    Protein attributes for P2RY11 Gene

    Size:
    374 amino acids
    Molecular mass:
    40345 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528).
    SequenceCaution:
    • Sequence=AAB88674.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC18877.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for P2RY11 Gene

neXtProt entry for P2RY11 Gene

Proteomics data for P2RY11 Gene at MOPED

Post-translational modifications for P2RY11 Gene

  • Glycosylation at Asn 4 and Asn 179
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY11 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for P2RY11 Gene

Domains & Families for P2RY11 Gene

Gene Families for P2RY11 Gene

Protein Domains for P2RY11 Gene

Suggested Antigen Peptide Sequences for P2RY11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G91

UniProtKB/Swiss-Prot:

P2Y11_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY11: view

Function for P2RY11 Gene

Molecular function for P2RY11 Gene

UniProtKB/Swiss-Prot Function:
Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP.
UniProtKB/Swiss-Prot Induction:
Increased by DMSO and retinoic acid.

Gene Ontology (GO) - Molecular Function for P2RY11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9405388
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY11: view
genes like me logo Genes that share phenotypes with P2RY11: view

Human Phenotype Ontology for P2RY11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for P2RY11 Gene

miRTarBase miRNAs that target P2RY11

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for P2RY11 Gene

Localization for P2RY11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY11 Gene COMPARTMENTS Subcellular localization image for P2RY11 gene
Compartment Confidence
nucleus 5
plasma membrane 5
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for P2RY11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IC 18048695
genes like me logo Genes that share ontologies with P2RY11: view

Pathways & Interactions for P2RY11 Gene

genes like me logo Genes that share pathways with P2RY11: view

Pathways by source for P2RY11 Gene

1 GeneGo (Thomson Reuters) pathway for P2RY11 Gene
1 Qiagen pathway for P2RY11 Gene

Interacting Proteins for P2RY11 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000323872%0d%0a9606.ENSP00000262225%0d%0a
Selected Interacting proteins: ENSP00000323872 for P2RY11 Gene via STRING

Symbol External ID(s) Details
TMED2

Gene Ontology (GO) - Biological Process for P2RY11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001973 adenosine receptor signaling pathway IDA 18048695
GO:0006952 defense response TAS 9405388
GO:0007186 G-protein coupled receptor signaling pathway IEA,IDA 18048695
GO:0007190 activation of adenylate cyclase activity TAS 9405388
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 9405388
genes like me logo Genes that share ontologies with P2RY11: view

No data available for SIGNOR curated interactions for P2RY11 Gene

Drugs & Compounds for P2RY11 Gene

(19) Drugs for P2RY11 Gene - From: DGIdb, Novoseek, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Suramin Approved Pharma Antagonist, antagonist 18
Uridine triphosphate Experimental Pharma 0
MC-1 Investigational Pharma 0
ATP Pharma Agonist 0
BzATP Pharma Full agonist, Agonist 0

(11) Additional Compounds for P2RY11 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ATPgammaS
Partial agonist, Agonist
Adpbetas
Agonist
UTP
Full agonist, Agonist
2-Methylthioadenosine diphosphate trisodium salt
475193-31-8
2-Methylthioadenosine triphosphate tetrasodium salt
100020-57-3

(5) Tocris Compounds for P2RY11 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
2-Methylthioadenosine triphosphate tetrasodium salt P2 purinergic agonist 100020-57-3
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
genes like me logo Genes that share compounds with P2RY11: view

Transcripts for P2RY11 Gene

mRNA/cDNA for P2RY11 Gene

Unigene Clusters for P2RY11 Gene

Purinergic receptor P2Y, G-protein coupled, 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY11 Gene

No ASD Table

Relevant External Links for P2RY11 Gene

GeneLoc Exon Structure for
P2RY11
ECgene alternative splicing isoforms for
P2RY11

Expression for P2RY11 Gene

mRNA expression in normal human tissues for P2RY11 Gene

Protein differential expression in normal tissues from HIPED for P2RY11 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for P2RY11 Gene



SOURCE GeneReport for Unigene cluster for P2RY11 Gene Hs.14468

mRNA Expression by UniProt/SwissProt for P2RY11 Gene

Q96G91-P2Y11_HUMAN
Tissue specificity: Highest expression in liver and spleen.
genes like me logo Genes that share expression patterns with P2RY11: view

Protein tissue co-expression partners for P2RY11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for P2RY11 Gene

Orthologs for P2RY11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for P2RY11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia P2RY11 35
  • 78.62 (n)
  • 70.92 (a)
P2RY11 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY11 35
  • 79.41 (n)
  • 72.58 (a)
chimpanzee
(Pan troglodytes)
Mammalia P2RY11 35
  • 98.57 (n)
  • 98.4 (a)
P2RY11 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia P2RY11 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry11 35
  • 55.52 (n)
  • 44.95 (a)
zebrafish
(Danio rerio)
Actinopterygii p2ry11 35
  • 51.5 (n)
  • 42.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta ppan 36
  • 8 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lpd-6 36
  • 5 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSF1 36
  • 8 (a)
ManyToMany
SSF2 36
  • 7 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2660 36
  • 8 (a)
OneToMany
Species with no ortholog for P2RY11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for P2RY11 Gene

ENSEMBL:
Gene Tree for P2RY11 (if available)
TreeFam:
Gene Tree for P2RY11 (if available)

Paralogs for P2RY11 Gene

(1) SIMAP similar genes for P2RY11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with P2RY11: view

No data available for Paralogs for P2RY11 Gene

Variants for P2RY11 Gene

Sequence variations from dbSNP and Humsavar for P2RY11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_020074 -

Structural Variations from Database of Genomic Variants (DGV) for P2RY11 Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV Loss 17160897
nsv911028 CNV Loss 21882294

Variation tolerance for P2RY11 Gene

Residual Variation Intolerance Score: 96.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.97% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RY11 Gene

HapMap Linkage Disequilibrium report
P2RY11
Human Gene Mutation Database (HGMD)
P2RY11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY11 Gene

Disorders for P2RY11 Gene

MalaCards: The human disease database

(1) MalaCards diseases for P2RY11 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
narcolepsy
  • narcolepsy, without cataplexy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for P2RY11

Genetic Association Database (GAD)
P2RY11
Human Genome Epidemiology (HuGE) Navigator
P2RY11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
P2RY11
genes like me logo Genes that share disorders with P2RY11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RY11 Gene

Publications for P2RY11 Gene

  1. Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. (PMID: 9405388) Communi D. … Boeynaems J.-M. (J. Biol. Chem. 1997) 2 3 4 23 67
  2. NAADP+ is an agonist of the human P2Y11 purinergic receptor. (PMID: 17707504) Moreschi I. … De Flora A. (Cell Calcium 2008) 3 23
  3. Hetero-oligomerization of the P2Y11 receptor with the P2Y1 receptor controls the internalization and ligand selectivity of the P2Y11 receptor. (PMID: 17824841) Ecke D. … Reiser G. (Biochem. J. 2008) 3 23
  4. Involvement of P2Y1 and P2Y11 purinoceptors in parasympathetic inhibition of colonic smooth muscle. (PMID: 18048695) King B.F. … Townsend-Nicholson A. (J. Pharmacol. Exp. Ther. 2008) 3 23
  5. Human pancreatic islets express the purinergic P2Y11 and P2Y12 receptors. (PMID: 18726826) Lugo-Garcia L. … Lajoix A.D. (Horm. Metab. Res. 2008) 3 23

Products for P2RY11 Gene

Sources for P2RY11 Gene

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