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P2RY11 Gene

protein-coding   GIFtS: 61
GCID: GC19P010222

Purinergic Receptor P2Y, G-Protein Coupled, 11

  See P2RY11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Purinergic Receptor P2Y, G-Protein Coupled, 111 2
P2Y112 3
P2Y Purinoceptor 112
Purinergic Receptor P2Y112

External Ids:    HGNC: 85401   Entrez Gene: 50322   Ensembl: ENSG000002441657   OMIM: 6026975   UniProtKB: Q96G913   

Export aliases for P2RY11 gene to outside databases

Previous GC identifers: GC19P010343 GC19P010445 GC19P010068 GC19P010083 GC19P009823


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for P2RY11 Gene:
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor
subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and
uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase
pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from
intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have
been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares
identity with each individual gene product. (provided by RefSeq, Jul 2008)

GeneCards Summary for P2RY11 Gene:
P2RY11 (purinergic receptor P2Y, G-protein coupled, 11) is a protein-coding gene. Diseases associated with P2RY11 include narcolepsy 1, and narcolepsy. GO annotations related to this gene include ATP-activated nucleotide receptor activity and receptor activity. An important paralog of this gene is PPAN-P2RY11.

UniProtKB/Swiss-Prot: P2Y11_HUMAN, Q96G91
Function: Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and
adenylyl cyclase second messenger systems. Not activated by UTP or UDP

summary for P2RY11 Gene:
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine
nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13
and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10
receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4
receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13
and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades
including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They
have diverse physiological roles including regulation of platelet aggregation, muscle contraction,
neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the P2RY11 gene promoter:
         Pax-6   GATA-2   Max   AREB6   FOXO1a   LyF-1   Zic3   FOXO1   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidP2RY11 promoter sequence
   Search Chromatin IP Primers for P2RY11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat P2RY11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13.2

P2RY11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P2RY11 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P010222:  view genomic region     (about GC identifiers)

Start:
10,222,197 bp from pter      End:
10,226,065 bp from pter
Size:
3,869 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: P2Y11_HUMAN, Q96G91 (See protein sequence)
Recommended Name: P2Y purinoceptor 11  
Size: 374 amino acids; 40345 Da
Miscellaneous: A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2,
has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can
be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting
chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively
indistinguishable (PubMed:11278528)
Sequence caution: Sequence=AAB88674.1; Type=Erroneous initiation; Sequence=CAC18877.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for P2RY11:
2B6S (3D)    
Secondary accessions: B2R8X9 O43190 Q9BYU4 Q9H170

Explore the universe of human proteins at neXtProt for P2RY11: NX_Q96G91

Explore proteomics data for P2RY11 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn4, Asn179

  • See P2RY11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002557.2  
    ENSEMBL proteins: 
     ENSP00000323872  
    Reactome Protein details: Q96G91

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    P2R: Purinergic receptors
    P2RY: GPCR / Class A : Purinergic receptors, P2Y

    IUPHAR Guide to PHARMACOLOGY protein family classification: P2Y11 receptor
    P2Y receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR027677 P2Y11_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q96G91

    ProtoNet protein and cluster: Q96G91

    UniProtKB/Swiss-Prot: P2Y11_HUMAN, Q96G91
    Similarity: Belongs to the G-protein coupled receptor 1 family


    Find genes that share domains with P2RY11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P2Y11_HUMAN, Q96G91
    Function: Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and
    adenylyl cyclase second messenger systems. Not activated by UTP or UDP
    Induction: Increased by DMSO and retinoic acid

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS9405388
    GO:0004930G-protein coupled receptor activity ----
    GO:0030594neurotransmitter receptor activity IDA18048695
    GO:0045028G-protein coupled purinergic nucleotide receptor activity IEA--
    GO:0045031ATP-activated nucleotide receptor activity IDA18048695
         
    Find genes that share ontologies with P2RY11           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for P2RY11:
     Increased gamma-H2AX phosphory 

    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P2Y11_HUMAN, Q96G91: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane5
    extracellular2
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane IC18048695
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with P2RY11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for P2RY11 About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    4Nucleotide-like (purinergic) receptors
    Nucleotide-like (purinergic) receptors
    P2Y receptors0.00
    5Development Angiotensin activation of ERK
    Signal transduction IP3 signaling0.43


    Find genes that share SuperPaths with P2RY11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for P2RY11
        P2Y Receptor Signaling

    1 GeneGo (Thomson Reuters) Pathway for P2RY11
        Signal transduction IP3 signaling

    2 BioSystems Pathways for P2RY11
        GPCRs, Other
    GPCRs, Class A Rhodopsin-like

    3 Reactome Pathways for P2RY11
        P2Y receptors
    G alpha (q) signalling events
    G alpha (s) signalling events


    1 Kegg Pathway  (Kegg details for P2RY11):
        Neuroactive ligand-receptor interaction

        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY11: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for P2RY11

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for P2RY11 (ENSP000003238724) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMED2ENSP000002622254STRING: ENSP00000262225
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001973adenosine receptor signaling pathway IDA18048695
    GO:0006952defense response TAS9405388
    GO:0007186G-protein coupled receptor signaling pathway IDA18048695
    GO:0007190activation of adenylate cyclase activity TAS9405388
    GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway TAS9405388

    Find genes that share ontologies with P2RY11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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      Browse compounds at ApexBio 

    Compounds for P2RY11 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MRS 2365Highly potent and selective P2Y1 agonist[436847-09-5]
    alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist[7292-42-4]
    UTPgammaS trisodium saltSelective P2Y2/4 agonist[1266569-94-1]
    MRS 2500 tetraammonium saltExtremely potent and selective P2Y1 antagonist[630103-23-0]
    MRS 2179 tetrasodium saltSelective P2Y1 antagonist[101204-49-3]

    1 HMDB Compound for P2RY11    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for P2RY11 (P2Y11 receptor) (see all 15)    About this table
    LigandTypeActionAffinityPubmed IDs
    AR-C67085
    AgonistFull agonist8.5210578132 15893764
    NF340
    AntagonistAntagonist7.35 - 7.718404494
    NF157
    AntagonistAntagonist7.3516250663
    NF546
    AgonistFull agonist6.2719815812
    suramin
    AntagonistAntagonist4.8 - 610578132
    ATP
    AgonistFull agonist4.2 - 5.610578132 12761346
    ATPgammaS
    AgonistFull agonist4.9 - 5.510578132
    UTP
    AgonistFull agonist5.212761346
    BzATP
    AgonistFull agonist5 - 5.110578132
    reactive blue-2
    AntagonistAntagonist510578132

    10 Novoseek inferred chemical compound relationships for P2RY11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    bzatp 82.7 1 16373435 (1)
    atpgammas 76.5 2 14710912 (2)
    atp 73 30 10947861 (4), 12761346 (4), 16904065 (2), 18056402 (2) (see all 16)
    suramin 70.5 6 16250663 (3), 16257449 (1), 10578132 (1)
    adp 67.1 1 15240747 (1)
    phosphoinositide 41.3 2 10578132 (1), 11116131 (1)
    cyclic amp 39.8 3 10578132 (3)
    calcium 39 4 12761346 (2), 17824841 (1), 15240747 (1)
    adenine 35 1 11754592 (1)
    inositol 1,4,5 trisphosphate 33.3 1 10578132 (1)



    Find genes that share compounds with P2RY11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for P2RY11 gene: 
    NM_002566.4  

    Unigene Cluster for P2RY11:

    Purinergic receptor P2Y, G-protein coupled, 11
    Hs.14468  [show with all ESTs]
    Unigene Representative Sequence: NM_001198690
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000321826(uc002mnc.3) ENST00000471843
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    Additional mRNA sequence: 

    AF498921.1 AJ292529.1 AJ298334.1 AK313550.1 AY449733.1 BC000535.2 BC009833.2 BC009877.2 
    BC033202.1 BC073827.1 

    14 DOTS entries:

    DT.211499  DT.100821323  DT.75119977  DT.100821341  DT.95317714  DT.95317710  DT.100821324  DT.121500258 
    DT.100821335  DT.100821339  DT.100821337  DT.100802317  DT.121500315  DT.97818761 

    Selected AceView cDNA sequences (see all 272):

    BM806612 CR610340 CR625570 BE901319 BU838574 NM_020230 CR590875 CF243024 
    CR614009 AA485047 BU179995 AW298633 AF030335 BM463374 CR601898 BG031634 
    BM766170 BM799124 BQ636394 CR599651 BQ051603 AF498921 BC009877 CR618663 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    P2RY11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGAAGGCAC
    P2RY11 Expression
    About this image

    P2RY11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    P2RY11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.14468

    UniProtKB/Swiss-Prot: P2Y11_HUMAN, Q96G91
    Tissue specificity: Highest expression in liver and spleen

        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY11: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for P2RY11 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia P2RY111 purinergic receptor P2Y, G-protein coupled, 11 79.41(n)
    72.58(a)
      100533479  NM_001204441.1  NP_001191370.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia p2ry111 purinergic receptor P2Y, G-protein coupled, 11 55.52(n)
    44.95(a)
      447996  NM_001005433.1  NP_001005433.1 
    zebrafish
    (Danio rerio)
    Actinopterygii p2ry111 purinergic receptor P2Y, G-protein coupled, 11 51.5(n)
    42.01(a)
      100007926  NM_001204454.1  NP_001191383.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ppan6
    peter pan
    8(a)
    1 → many
    3R(16941976-16943621)
    worm
    (Caenorhabditis elegans)
    Secernentea lpd-66
    Protein LPD-6 (lpd-6) mRNA, complete cds
    5(a)
    1 → many
    I(3144411-3147859) WBGene00003062
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SSF16
    SSF26
    Constituent of 66S pre-ribosomal particles, requir...
    Protein required for ribosomal large subunit matur...
    8(a)
    7(a)
    many ↔ many
    many ↔ many
    VIII(229335-230696) YHR066W
    IV(1087581-1088942) YDR312W


    ENSEMBL Gene Tree for P2RY11 (if available)
    TreeFam Gene Tree for P2RY11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for P2RY11 gene
    PPAN-P2RY112  PPAN2  
    1 SIMAP similar gene for P2RY11 using alignment to 1 protein entry:     P2Y11_HUMAN:
    P2RY1

    Find genes that share paralogs with P2RY11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for P2RY11    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37456011,2,4
    ----see VAR_0200742 mis40--------

    HapMap Linkage Disequilibrium report for P2RY11 (10222197 - 10226065 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for P2RY11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911028CNV Loss21882294
    nsv833743CNV Loss17160897

    Human Gene Mutation Database (HGMD): P2RY11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing P2RY11
    DNA2.0 Custom Variant and Variant Library Synthesis for P2RY11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602697    OMIM disorders: --

    2 diseases for P2RY11:    
    About MalaCards
    narcolepsy 1    narcolepsy


    Find genes that share disorders with P2RY11           About GenesLikeMe

    2 Novoseek inferred disease relationships for P2RY11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 61 5 17824841 (1), 17707504 (1), 10578132 (1), 11723245 (1) (see all 5)
    inflammation 0 1 18056402 (1)

    Genetic Association Database (GAD): P2RY11
    Human Genome Epidemiology (HuGE) Navigator: P2RY11 (2 documents)

    Export disorders for P2RY11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for P2RY11 gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with P2RY11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. (PubMed id 9405388)1, 2, 3, 9 Communi D.... Boeynaems J.-M. (J. Biol. Chem. 1997)
    2. Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes. (PubMed id 11278528)1, 2, 9 Communi D.... Boeynaems J.-M. (J. Biol. Chem. 2001)
    3. Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y11. (PubMed id 17135283)1, 4, 9 Amisten S....Erlinge D. (Eur. Heart J. 2007)
    4. Common variants in P2RY11 are associated with narcolepsy. (PubMed id 21170044)1, 4 Kornum B.R....Mignot E. (Nat. Genet. 2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Hetero-oligomerization of the P2Y11 receptor with the P2Y1 receptor controls the internalization and ligand selectivity of the P2Y11 receptor. (PubMed id 17824841)1, 9 Ecke D....Reiser G. (Biochem. J. 2008)
    7. Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor. (PubMed id 18056402)1, 9 Vaughan K.R....Whyte M.K. (J. Immunol. 2007)
    8. Signal transduction and white cell maturation via extracellular ATP and the P2Y11 receptor. (PubMed id 10947861)1, 9 van der Weyden L....Morris M.B. (Immunol. Cell Biol. 2000)
    9. NAADP+ is an agonist of the human P2Y11 purinergic receptor. (PubMed id 17707504)1, 9 Moreschi I....De Flora A. (Cell Calcium 2008)
    10. Involvement of P2Y1 and P2Y11 purinoceptors in parasympathetic inhibition of colonic smooth muscle. (PubMed id 18048695)1, 9 King B.F. and Townsend-Nicholson A. (J. Pharmacol. Exp. Ther. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5032 HGNC: 8540 AceView: P2RY11andPPAN Ensembl:ENSG00000244165 euGenes: HUgn5032
    ECgene: P2RY11 Kegg: 5032 H-InvDB: P2RY11

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for P2RY11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for P2RY11 gene:
    Search GeneIP for patents involving P2RY11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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