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Aliases for P2RY11 Gene

Aliases for P2RY11 Gene

  • Purinergic Receptor P2Y, G-Protein Coupled, 11 2 3
  • P2Y11 3 4
  • Purinergic Receptor P2Y11 3
  • P2Y Purinoceptor 11 3

External Ids for P2RY11 Gene

Summaries for P2RY11 Gene

Entrez Gene Summary for P2RY11 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is coupled to the stimulation of the phosphoinositide and adenylyl cyclase pathways and behaves as a selective purinoceptor. Naturally occuring read-through transcripts, resulting from intergenic splicing between this gene and an immediately upstream gene (PPAN, encoding peter pan homolog), have been found. The PPAN-P2RY11 read-through mRNA is ubiquitously expressed and encodes a fusion protein that shares identity with each individual gene product. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY11 Gene

P2RY11 (Purinergic Receptor P2Y, G-Protein Coupled, 11) is a Protein Coding gene. Diseases associated with P2RY11 include narcolepsy. Among its related pathways are GPCR Pathway and Signaling by GPCR. GO annotations related to this gene include receptor activity and ATP-activated nucleotide receptor activity. An important paralog of this gene is PPAN-P2RY11.

UniProtKB/Swiss-Prot for P2RY11 Gene

  • Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP

Tocris Summary for P2RY11 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10 receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4 receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13 and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They have diverse physiological roles including regulation of platelet aggregation, muscle contraction, neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY11 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY11 Gene

Genomics for P2RY11 Gene

Genomic Location for P2RY11 Gene

Start:
10,111,521 bp from pter
End:
10,115,389 bp from pter
Size:
3,869 bases
Orientation:
Plus strand

Genomic View for P2RY11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for P2RY11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY11 Gene

Regulatory Elements for P2RY11 Gene

Proteins for P2RY11 Gene

  • Protein details for P2RY11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G91-P2Y11_HUMAN
    Recommended name:
    P2Y purinoceptor 11
    Protein Accession:
    Q96G91
    Secondary Accessions:
    • B2R8X9
    • O43190
    • Q9BYU4
    • Q9H170

    Protein attributes for P2RY11 Gene

    Size:
    374 amino acids
    Molecular mass:
    40345 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • A chimeric transcript, characterized by the first third of PPAN exon 12 joined to P2RY11 exon 2, has been detected. It is possibly produced by trans-splicing. The chimeric transcript is widely expressed and can be induced by retinoic acid during the granulocytic differentiation of the HL-60 cell line. The resulting chimeric protein shows a much lower activity than the non-chimeric P2RY11 gene product, but qualitatively indistinguishable (PubMed:11278528).
    SequenceCaution:
    • Sequence=AAB88674.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC18877.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for P2RY11 Gene

neXtProt entry for P2RY11 Gene

Proteomics data for P2RY11 Gene at MOPED

Post-translational modifications for P2RY11 Gene

Other Protein References for P2RY11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for P2RY11 Gene

Domains for P2RY11 Gene

Gene Families for P2RY11 Gene

HGNC:
  • P2R :Purinergic receptors
  • P2RY :GPCR / Class A : Purinergic receptors, P2Y
IUPHAR :

Protein Domains for P2RY11 Gene

Suggested Antigen Peptide Sequences for P2RY11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G91

UniProtKB/Swiss-Prot:

P2Y11_HUMAN
Family:
  • Belongs to the G-protein coupled receptor 1 family.:
    • Q96G91
genes like me logo Genes that share domains with P2RY11: view

Function for P2RY11 Gene

Molecular function for P2RY11 Gene

UniProtKB/Swiss-Prot Function: Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP
UniProtKB/Swiss-Prot Induction: Increased by DMSO and retinoic acid

Gene Ontology (GO) - Molecular Function for P2RY11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 9405388
GO:0004930 G-protein coupled receptor activity --
GO:0030594 neurotransmitter receptor activity IDA 18048695
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
GO:0045031 ATP-activated nucleotide receptor activity IDA 18048695
genes like me logo Genes that share ontologies with P2RY11: view

Phenotypes for P2RY11 Gene

GenomeRNAi human phenotypes for P2RY11:
genes like me logo Genes that share phenotypes with P2RY11: view

miRNA for P2RY11 Gene

miRTarBase miRNAs that target P2RY11

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for P2RY11 Gene

Localization for P2RY11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY11 Gene COMPARTMENTS Subcellular localization image for P2RY11 gene
Compartment Confidence
nucleus 5
plasma membrane 5
extracellular 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for P2RY11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 18048695
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with P2RY11: view

Pathways for P2RY11 Gene

genes like me logo Genes that share pathways with P2RY11: view

Pathways by source for P2RY11 Gene

1 GeneGo (Thomson Reuters) pathway for P2RY11 Gene
1 Qiagen pathway for P2RY11 Gene
2 BioSystems pathways for P2RY11 Gene

Interacting Proteins for P2RY11 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000323872%0d%0a9606.ENSP00000262225%0d%0a
Selected Interacting proteins: ENSP00000323872 for P2RY11 Gene via STRING

Symbol External ID(s) Details
TMED2

Gene Ontology (GO) - Biological Process for P2RY11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001973 adenosine receptor signaling pathway IDA 18048695
GO:0006952 defense response TAS 9405388
GO:0007186 G-protein coupled receptor signaling pathway IDA 18048695
GO:0007190 activation of adenylate cyclase activity TAS 9405388
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway TAS 9405388
genes like me logo Genes that share ontologies with P2RY11: view

Compounds for P2RY11 Gene

(5) Tocris Compounds for P2RY11 Gene

Compound Action Cas Number
alpha,beta-Methyleneadenosine 5-triphosphate trisodium salt P2 agonist [7292-42-4]
MRS 2179 tetrasodium salt Selective P2Y1 antagonist [101204-49-3]
MRS 2365 Highly potent and selective P2Y1 agonist [436847-09-5]
MRS 2500 tetraammonium salt Extremely potent and selective P2Y1 antagonist [630103-23-0]
UTPgammaS trisodium salt Selective P2Y2/4 agonist [1266569-94-1]

(1) HMDB Compounds for P2RY11 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(15) IUPHAR Ligand for P2RY11 Gene

Ligand Type Action Affinity Pubmed IDs
AR-C67085 Agonist Full agonist 8.52
NF340 Antagonist Antagonist 7.7
NF157 Antagonist Antagonist 7.35
NF546 Agonist Full agonist 6.27
ATPgammaS Agonist Full agonist 5.5
UTP Agonist Full agonist 5.2
BzATP Agonist Full agonist 5.1
reactive blue-2 Antagonist Antagonist 5
dATP Agonist Full agonist 5
ADPbetaS Agonist Full agonist 4.5
2MeSATP Agonist Full agonist 4.3
NAADP Activator Agonist 3.1
suramin Activator None
ATP Activator None
NAD Activator Agonist

(10) Novoseek inferred chemical compound relationships for P2RY11 Gene

Compound -log(P) Hits PubMed IDs
bzatp 82.7 1
atpgammas 76.5 2
atp 73 26
suramin 70.5 5
adp 67.1 1
genes like me logo Genes that share compounds with P2RY11: view

Transcripts for P2RY11 Gene

mRNA/cDNA for P2RY11 Gene

Unigene Clusters for P2RY11 Gene

Purinergic receptor P2Y, G-protein coupled, 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY11 Gene

No ASD Table

Relevant External Links for P2RY11 Gene

GeneLoc Exon Structure for
P2RY11
ECgene alternative splicing isoforms for
P2RY11

Expression for P2RY11 Gene

mRNA expression in normal human tissues for P2RY11 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for P2RY11 Gene

SOURCE GeneReport for Unigene cluster for P2RY11 Gene Hs.14468

mRNA Expression by UniProt/SwissProt for P2RY11 Gene

Q96G91-P2Y11_HUMAN
Tissue specificity: Highest expression in liver and spleen.
genes like me logo Genes that share expressions with P2RY11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for P2RY11 Gene

Orthologs for P2RY11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for P2RY11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY11 35
  • 98.57 (n)
  • 98.4 (a)
P2RY11 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia P2RY11 35
  • 78.62 (n)
  • 70.92 (a)
P2RY11 36
  • 68 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY11 35
  • 79.41 (n)
  • 72.58 (a)
oppossum
(Monodelphis domestica)
Mammalia P2RY11 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry11 35
  • 55.52 (n)
  • 44.95 (a)
zebrafish
(Danio rerio)
Actinopterygii p2ry11 35
  • 51.5 (n)
  • 42.01 (a)
fruit fly
(Drosophila melanogaster)
Insecta ppan 36
  • 8 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lpd-6 36
  • 5 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SSF1 36
  • 8 (a)
ManyToMany
SSF2 36
  • 7 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2660 36
  • 8 (a)
OneToMany
Species with no ortholog for P2RY11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for P2RY11 Gene

ENSEMBL:
Gene Tree for P2RY11 (if available)
TreeFam:
Gene Tree for P2RY11 (if available)

Paralogs for P2RY11 Gene

Paralogs for P2RY11 Gene

Selected SIMAP similar genes for P2RY11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with P2RY11: view

Variants for P2RY11 Gene

Sequence variations from dbSNP and Humsavar for P2RY11 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_020074 -

Structural Variations from Database of Genomic Variants (DGV) for P2RY11 Gene

Variant ID Type Subtype PubMed ID
nsv833743 CNV Loss 17160897
nsv911028 CNV Loss 21882294

Relevant External Links for P2RY11 Gene

HapMap Linkage Disequilibrium report
P2RY11
Human Gene Mutation Database (HGMD)
P2RY11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RY11 Gene

Disorders for P2RY11 Gene

(1) MalaCards Diseases for P2RY11 Gene

Search for P2RY11 Gene in MalaCards »

(2) Novoseek inferred disease relationships for P2RY11 Gene

Disease -log(P) Hits PubMed IDs
astrocytoma 61 5
inflammation 0 1

Relevant External Links for P2RY11

Genetic Association Database (GAD)
P2RY11
Human Genome Epidemiology (HuGE) Navigator
P2RY11
genes like me logo Genes that share disorders with P2RY11: view

No data available for UniProtKB/Swiss-Prot for P2RY11 Gene

Publications for P2RY11 Gene

  1. Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase. (PMID: 9405388) Communi D. … Boeynaems J.-M. (J. Biol. Chem. 1997) 2 3 4 23
  2. Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes. (PMID: 11278528) Communi D. … Boeynaems J.-M. (J. Biol. Chem. 2001) 3 4 23
  3. Increased risk of acute myocardial infarction and elevated levels of C-reactive protein in carriers of the Thr-87 variant of the ATP receptor P2Y11. (PMID: 17135283) Amisten S. … Erlinge D. (Eur. Heart J. 2007) 3 23 48
  4. Structure and ligand-binding site characteristics of the human P2Y11 nucleotide receptor deduced from computational modelling and mutational analysis. (PMID: 17338680) Zylberg J. … Reiser G. (Biochem. J. 2007) 3 23
  5. NAADP+ is an agonist of the human P2Y11 purinergic receptor. (PMID: 17707504) Moreschi I. … De Flora A. (Cell Calcium 2008) 3 23

Products for P2RY11 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate P2RY11
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for P2RY11
    • Block miRNA regulation of P2RY11 using miScript Target Protectors

    Sources for P2RY11 Gene

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