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Aliases for P2RY10 Gene

Aliases for P2RY10 Gene

  • Purinergic Receptor P2Y10 2 3
  • Purinergic Receptor P2Y, G-Protein Coupled, 10 2 3 5
  • P2Y-Like Receptor 3 4
  • P2Y10 3 4
  • G-Protein Coupled Purinergic Receptor P2Y10 3
  • LYPSR2 3

External Ids for P2RY10 Gene

Previous GeneCards Identifiers for P2RY10 Gene

  • GC0XP075162
  • GC0XP076242
  • GC0XP076956
  • GC0XP078006
  • GC0XP078087
  • GC0XP078200
  • GC0XP071781

Summaries for P2RY10 Gene

Entrez Gene Summary for P2RY10 Gene

  • The protein encoded by this gene belongs to the family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. There is a pseudogene for this gene nearby on chromosome X. Multiple alternatively spliced transcripts have been observed. [provided by RefSeq, Apr 2016]

GeneCards Summary for P2RY10 Gene

P2RY10 (Purinergic Receptor P2Y10) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is P2RY2.

UniProtKB/Swiss-Prot for P2RY10 Gene

  • Putative receptor for purines coupled to G-proteins.

Tocris Summary for P2RY10 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY10 Gene

Genomics for P2RY10 Gene

Regulatory Elements for P2RY10 Gene

Enhancers for P2RY10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around P2RY10 on UCSC Golden Path with GeneCards custom track

Genomic Location for P2RY10 Gene

Chromosome:
X
Start:
78,945,332 bp from pter
End:
78,963,727 bp from pter
Size:
18,396 bases
Orientation:
Plus strand

Genomic View for P2RY10 Gene

Genes around P2RY10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY10 Gene

Proteins for P2RY10 Gene

  • Protein details for P2RY10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00398-P2Y10_HUMAN
    Recommended name:
    Putative P2Y purinoceptor 10
    Protein Accession:
    O00398
    Secondary Accessions:
    • D3DTE5
    • Q4VBN7
    • Q86V16

    Protein attributes for P2RY10 Gene

    Size:
    339 amino acids
    Molecular mass:
    38774 Da
    Quaternary structure:
    No Data Available

neXtProt entry for P2RY10 Gene

Proteomics data for P2RY10 Gene at MOPED

Post-translational modifications for P2RY10 Gene

  • Glycosylation at Asn 16, Asn 26, and Asn 178
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY10 Gene

No data available for DME Specific Peptides for P2RY10 Gene

Domains & Families for P2RY10 Gene

Gene Families for P2RY10 Gene

Protein Domains for P2RY10 Gene

Suggested Antigen Peptide Sequences for P2RY10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00398

UniProtKB/Swiss-Prot:

P2Y10_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY10: view

Function for P2RY10 Gene

Molecular function for P2RY10 Gene

UniProtKB/Swiss-Prot Function:
Putative receptor for purines coupled to G-proteins.

Gene Ontology (GO) - Molecular Function for P2RY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY10: view
genes like me logo Genes that share phenotypes with P2RY10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for P2RY10

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for P2RY10 Gene

Localization for P2RY10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY10 Gene COMPARTMENTS Subcellular localization image for P2RY10 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for P2RY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with P2RY10: view

Pathways & Interactions for P2RY10 Gene

genes like me logo Genes that share pathways with P2RY10: view

Interacting Proteins for P2RY10 Gene

Gene Ontology (GO) - Biological Process for P2RY10 Gene

None

No data available for SIGNOR curated interactions for P2RY10 Gene

Drugs & Compounds for P2RY10 Gene

(5) Drugs for P2RY10 Gene - From: DGIdb and IUPHAR

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MC-1 Investigational Pharma 0
JTE-013 Pharma Antagonist 0
LPA Pharma Agonist 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist Endogenous agonist at S1P1-5 0
DIOCTANOY​LGLYCEROL​ PYROPHOS​PHATE Pharma 0

(6) Additional Compounds for P2RY10 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dioctanoy?aelglycerol?ae pyrophos?aephate
Antagonist
2-Methylthioadenosine diphosphate trisodium salt
475193-31-8
2-Methylthioadenosine triphosphate tetrasodium salt
100020-57-3
MRS 2365
436847-09-5
MRS 2693 trisodium salt
1448858-83-0

(5) Tocris Compounds for P2RY10 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
2-Methylthioadenosine triphosphate tetrasodium salt P2 purinergic agonist 100020-57-3
MRS 2365 Highly potent and selective P2Y1 agonist 436847-09-5
MRS 2693 trisodium salt Selective P2Y6 agonist 1448858-83-0
PSB 0474 Potent and selective P2Y6 agonist 917567-60-3
genes like me logo Genes that share compounds with P2RY10: view

Transcripts for P2RY10 Gene

Unigene Clusters for P2RY10 Gene

Purinergic receptor P2Y, G-protein coupled, 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for P2RY10 Gene

GeneLoc Exon Structure for
P2RY10
ECgene alternative splicing isoforms for
P2RY10

Expression for P2RY10 Gene

mRNA expression in normal human tissues for P2RY10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY10 Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for P2RY10 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for P2RY10 Gene



SOURCE GeneReport for Unigene cluster for P2RY10 Gene Hs.296433

mRNA Expression by UniProt/SwissProt for P2RY10 Gene

O00398-P2Y10_HUMAN
Tissue specificity: Weakly expressed in blood leukocytes.
genes like me logo Genes that share expression patterns with P2RY10: view

Protein tissue co-expression partners for P2RY10 Gene

- Elite partner

Primer Products

Orthologs for P2RY10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia P2RY10 35
  • 89.09 (n)
  • 89.6 (a)
P2RY10 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY10 35
  • 90.21 (n)
  • 90.52 (a)
P2RY10 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia P2ry10 35
  • 85.42 (n)
  • 86.24 (a)
P2ry10 16
P2ry10 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2ry10 35
  • 85.42 (n)
  • 85.63 (a)
oppossum
(Monodelphis domestica)
Mammalia P2RY10 36
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves P2RY10 35
  • 68.37 (n)
  • 68.69 (a)
-- 36
  • 67 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry10 35
  • 62.19 (n)
  • 61.64 (a)
zebrafish
(Danio rerio)
Actinopterygii p2ry10 35
  • 59.14 (n)
  • 58.47 (a)
p2ry10 36
  • 54 (a)
OneToOne
Species with no ortholog for P2RY10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY10 Gene

ENSEMBL:
Gene Tree for P2RY10 (if available)
TreeFam:
Gene Tree for P2RY10 (if available)

Paralogs for P2RY10 Gene

(9) SIMAP similar genes for P2RY10 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for P2RY10 Gene

genes like me logo Genes that share paralogs with P2RY10: view

Variants for P2RY10 Gene

Sequence variations from dbSNP and Humsavar for P2RY10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs6618868 - 78,960,527(+) TGGCT(A/C)ACCTT reference, missense
rs747701136 -- 78,953,629(+) TCTGA(A/C)TTTTA intron-variant
rs747717928 -- 78,959,666(+) TAGTG(C/T)CCAAA intron-variant
rs747790071 -- 78,960,521(+) AATCC(A/G)TGGCT reference, missense
rs747831150 -- 78,946,935(+) GCCTG(A/C)TGGGC intron-variant

Variation tolerance for P2RY10 Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RY10 Gene

HapMap Linkage Disequilibrium report
P2RY10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for P2RY10 Gene

Disorders for P2RY10 Gene

Relevant External Links for P2RY10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
P2RY10

No disorders were found for P2RY10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for P2RY10 Gene

Publications for P2RY10 Gene

  1. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PMID: 11004484) Adrian K. … Ogilvie A. (Biochim. Biophys. Acta 2000) 2 3 4 67
  2. Receptors for purines and pyrimidines. (PMID: 9755289) Ralevic V. … Burnstock G. (Pharmacol. Rev. 1998) 2 3
  3. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. (PMID: 24602016) Kihara Y. … Chun J. (Br. J. Pharmacol. 2014) 3
  4. Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors. (PMID: 18240029) Luttrell L.M. (Mol. Biotechnol. 2008) 3
  5. Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor. (PMID: 18466763) Murakami M. … Fujita N. (Biochem. Biophys. Res. Commun. 2008) 3

Products for P2RY10 Gene

Sources for P2RY10 Gene

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