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Aliases for P2RY10 Gene

Aliases for P2RY10 Gene

  • Purinergic Receptor P2Y, G-Protein Coupled, 10 2 3
  • P2Y10 3 4 6
  • P2Y-Like Receptor 3 4
  • G-Protein Coupled Purinergic Receptor P2Y10 3
  • Putative P2Y Purinoceptor 10 3
  • P2Y Purinoceptor 10 3
  • LYPSR2 3

External Ids for P2RY10 Gene

Previous GeneCards Identifiers for P2RY10 Gene

  • GC0XP075162
  • GC0XP076242
  • GC0XP076956
  • GC0XP078006
  • GC0XP078087
  • GC0XP078200
  • GC0XP071781

Summaries for P2RY10 Gene

Entrez Gene Summary for P2RY10 Gene

  • The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. Two alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY10 Gene

P2RY10 (Purinergic Receptor P2Y, G-Protein Coupled, 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is PTAFR.

UniProtKB/Swiss-Prot for P2RY10 Gene

  • Putative receptor for purines coupled to G-proteins

Tocris Summary for P2RY10 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10 receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4 receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13 and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They have diverse physiological roles including regulation of platelet aggregation, muscle contraction, neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY10 Gene

Genomics for P2RY10 Gene

Regulatory Elements for P2RY10 Gene

Genomic Location for P2RY10 Gene

Start:
78,945,332 bp from pter
End:
78,963,727 bp from pter
Size:
18,396 bases
Orientation:
Plus strand

Genomic View for P2RY10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for P2RY10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY10 Gene

Proteins for P2RY10 Gene

  • Protein details for P2RY10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00398-P2Y10_HUMAN
    Recommended name:
    Putative P2Y purinoceptor 10
    Protein Accession:
    O00398
    Secondary Accessions:
    • D3DTE5
    • Q4VBN7
    • Q86V16

    Protein attributes for P2RY10 Gene

    Size:
    339 amino acids
    Molecular mass:
    38774 Da
    Quaternary structure:
    No Data Available

neXtProt entry for P2RY10 Gene

Proteomics data for P2RY10 Gene at MOPED

Post-translational modifications for P2RY10 Gene

  • Glycosylation at Asn16, Asn26, and Asn178
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for P2RY10 Gene

Domains for P2RY10 Gene

Gene Families for P2RY10 Gene

HGNC:
  • P2RY :GPCR / Class A : Purinergic receptors, P2Y
  • P2R :Purinergic receptors
IUPHAR :

Protein Domains for P2RY10 Gene

Suggested Antigen Peptide Sequences for P2RY10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O00398

UniProtKB/Swiss-Prot:

P2Y10_HUMAN :
  • O00398
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY10: view

Function for P2RY10 Gene

Molecular function for P2RY10 Gene

UniProtKB/Swiss-Prot Function: Putative receptor for purines coupled to G-proteins

Gene Ontology (GO) - Molecular Function for P2RY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY10: view

Phenotypes for P2RY10 Gene

GenomeRNAi human phenotypes for P2RY10:
genes like me logo Genes that share phenotypes with P2RY10: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for P2RY10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for P2RY10 Gene

Localization for P2RY10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY10 Gene COMPARTMENTS Subcellular localization image for P2RY10 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for P2RY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with P2RY10: view

Pathways for P2RY10 Gene

genes like me logo Genes that share pathways with P2RY10: view

Pathways by source for P2RY10 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • G Protein Coupled Receptors 384HT in human,mouse,rat

Interacting Proteins for P2RY10 Gene

Gene Ontology (GO) - Biological Process for P2RY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with P2RY10: view

Compounds for P2RY10 Gene

(5) Tocris Compounds for P2RY10 Gene

Compound Action Cas Number
alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist [1343364-54-4]
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 [475193-31-8]
MRS 2179 tetrasodium salt Selective P2Y1 antagonist [1454889-37-2]
MRS 2365 Highly potent and selective P2Y1 agonist [436847-09-5]
MRS 2500 tetraammonium salt Extremely potent and selective P2Y1 antagonist [630103-23-0]

(4) IUPHAR Ligand for P2RY10 Gene

Ligand Type Action Affinity Pubmed IDs
sphingosine 1-phosphate Agonist Agonist 8.96
JTE-013 Antagonist Antagonist 7.77
dioctanoy?aelglycerol?ae pyrophos?aephate Antagonist Antagonist 7
LPA Agonist Agonist 5.6
genes like me logo Genes that share compounds with P2RY10: view

Transcripts for P2RY10 Gene

mRNA/cDNA for P2RY10 Gene

Unigene Clusters for P2RY10 Gene

Purinergic receptor P2Y, G-protein coupled, 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for P2RY10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for P2RY10 Gene

GeneLoc Exon Structure for
P2RY10
ECgene alternative splicing isoforms for
P2RY10

Expression for P2RY10 Gene

mRNA expression in normal human tissues for P2RY10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY10 Gene

This gene is overexpressed in Whole Blood (5.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for P2RY10 Gene

SOURCE GeneReport for Unigene cluster for P2RY10 Gene Hs.296433

mRNA Expression by UniProt/SwissProt for P2RY10 Gene

O00398-P2Y10_HUMAN
Tissue specificity: Weakly expressed in blood leukocytes.
genes like me logo Genes that share expressions with P2RY10: view

In Situ Assay Products

Orthologs for P2RY10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia P2RY10 35
  • 89.09 (n)
  • 89.6 (a)
P2RY10 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY10 35
  • 90.21 (n)
  • 90.52 (a)
P2RY10 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia P2ry10 35
  • 85.42 (n)
  • 86.24 (a)
P2ry10 16
P2ry10 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia P2RY10 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2ry10 35
  • 85.42 (n)
  • 85.63 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 67 (a)
OneToMany
-- 36
  • 57 (a)
OneToMany
P2RY10 35
  • 68.37 (n)
  • 68.69 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 54 (a)
OneToMany
-- 36
  • 49 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry10 35
  • 62.19 (n)
  • 61.64 (a)
zebrafish
(Danio rerio)
Actinopterygii p2ry10 35
  • 59.14 (n)
  • 58.47 (a)
p2ry10 36
  • 54 (a)
OneToOne
Species with no ortholog for P2RY10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY10 Gene

ENSEMBL:
Gene Tree for P2RY10 (if available)
TreeFam:
Gene Tree for P2RY10 (if available)

Paralogs for P2RY10 Gene

Selected SIMAP similar genes for P2RY10 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for P2RY10 Gene

genes like me logo Genes that share paralogs with P2RY10: view

Variants for P2RY10 Gene

Sequence variations from dbSNP and Humsavar for P2RY10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs527098 -- 78,954,891(+) AGGTC(A/G)CTAGG intron-variant
rs536789 -- 78,944,864(-) GAGGG(C/T)AAAGA upstream-variant-2KB
rs612005 -- 78,954,844(-) CTCCA(G/T)AAGCA intron-variant
rs964940 -- 78,952,784(-) AACAC(A/G)CATAA intron-variant
rs1005490 -- 78,944,496(-) TGGGA(A/T)GATTG upstream-variant-2KB

Relevant External Links for P2RY10 Gene

HapMap Linkage Disequilibrium report
P2RY10
Locus Specific Mutation Databases (LSDB)
P2RY10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for P2RY10 Gene

Disorders for P2RY10 Gene

No disorders were found for P2RY10 Gene.

No data available for UniProtKB/Swiss-Prot for P2RY10 Gene

Publications for P2RY10 Gene

  1. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PMID: 11004484) Adrian K. … Ogilvie A. (Biochim. Biophys. Acta 2000) 2 3 4
  2. Receptors for purines and pyrimidines. (PMID: 9755289) Ralevic V. … Burnstock G. (Pharmacol. Rev. 1998) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4
  5. Stable association between G alpha(q) and phospholipase C beta 1 in living cells. (PMID: 16754659) Dowal L. … Scarlata S. (J. Biol. Chem. 2006) 3

Products for P2RY10 Gene

Sources for P2RY10 Gene

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