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P2RY10 Gene

protein-coding   GIFtS: 54

GC0XP078006
purinergic receptor P2Y, G-protein coupled, 10
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for P2RY10

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
OTTHUMP00000023599 2
P2Y10 1, 2, 3
Descriptions
G-protein coupled purinergic receptor P2Y10 2
P2Y purinoceptor 10 2
P2Y-like receptor 2, 3
purinergic receptor P2Y, G-protein coupled, 10 2
External Ids
HGNC: 199061
Entrez Gene: 273342
UniProtKB: O003983
Ensembl: ENSG000000785897
Search outside databases for aliases for P2RY10 gene

Previous GC identifers: GC0XP075162 GC0XP076242 GC0XP076956

Summaries
for P2RY10

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for P2RY10:
The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are
preferentially activated by adenosine and uridine nucleotides. Two alternatively spliced
transcript variants encoding the same protein isoform have been found for this gene. [provided by
RefSeq]

UniProtKB/Swiss-Prot: P2Y10_HUMAN, O00398
Function: Putative receptor for purines coupled to G-proteins

Gene Wiki entry for P2RY10

Genomic Location
for P2RY10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the P2RY10 gene  

Entrez Gene cytogenetic band: Xq21.1   Ensembl cytogenetic band:  Xq21.1   HGNC cytogenetic band: Xq21.1

P2RY10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP078006:     (about GC identifiers)

Start:
 78,087,485 bp from pter
End:
 78,104,094 bp from pter
Size:
 16,610 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000023.9  NT_011651.16  

Proteins
for P2RY10

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: P2Y10_HUMAN, O00398 (See protein sequence)
Recommended Name: Putative P2Y purinoceptor 10  
Size: 339 amino acids; 38774 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Developmental stage: Up-regulated during promyelocytic cell differentiation along the monocytic
pathway, but not during granulocytic differentiation
Secondary accessions: Q4VBN7 Q86V16

REFSEQ proteins (2 alternative transcripts): 
NP_055314.1  NP_938147.1  


ENSEMBL proteins: 
ENSP00000171757 ENSP00000378891 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (P2Y10)
Human Recombinant Proteins from Abnova (P2RY10)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane IEA--
GO:0016021 integral to membrane IEA--
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Antibodies for P2RY10: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of P2RY10
Sigma-Aldrich Antibodies for P2RY10
Browse R&D Systems for Antibodies
Antibodies from Abcam (P2Y10), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (P2RY10)
Novus Biologicals Antibody for P2RY10

Assays for P2RY10: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for P2RY10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_supfam
 IPR000276 7TM_GPCR_Rhodpsn
 IPR002286 P2_purnocptor


   GeneDecks  P2RY10 for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry O00398

ProtoNet protein and cluster: O00398

UniProtKB/Swiss-Prot: P2Y10_HUMAN, O00398
Similarity: Belongs to the G-protein coupled receptor 1 family

Gene Function
for P2RY10

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (P2RY10)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (P2RY10)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_014499

              Applied Biosystems Silencer® siRNAs for P2RY10

              Sigma-Aldrich siRNA and siRNA Panels for P2RY10  
                     Sigma-Aldrich shRNA Panels and shRNA for P2RY10  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for P2RY10
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_014499
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_014499
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_014499 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_198333

UniProtKB/Swiss-Prot: P2Y10_HUMAN, O00398
Function: Putative receptor for purines coupled to G-proteins

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004872 receptor activity IEA--
GO:0004930 G-protein coupled receptor activity IEA--
GO:0045028 purinergic nucleotide receptor activity, G-protein coupled IEA--
About this table

Pathways & Interactions
for P2RY10

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section


1 Kegg Pathway  (Kegg details for P2RY10):
 hsa04080 Neuroactive ligand-receptor interaction

   GeneDecks  P2RY10 for the pathways selected above  
About GeneDecksing

2 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007165 signal transduction IEA--
GO:0007186 G-protein coupled receptor protein signaling pathway IEA--
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Drugs & Compounds
for P2RY10

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Sigma-Aldrich Small Molecules for P2RY10:
Antagonist Agonist

Compounds for P2RY10 available from Tocris Bioscience
CompoundAction CAS number
Suramin hexasodium saltNon-selective P2 antagonist[129-46-4]
2-Methylthioadenosine triphosphate tetrasodium saltP2 purinergic agonist[43170-89-4]
PPADS tetrasodium saltP2 purinergic antagonist[149017-66-3]
About this table



Transcripts
for P2RY10

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (P2RY10)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (P2RY10)
               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_014499

              Sigma-Aldrich siRNA and siRNA Panels for P2RY10  
                     Sigma-Aldrich shRNA Panels and shRNA for P2RY10  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_014499  NM_198333  

REFSEQ mRNAs for P2RY10 gene (2 alternative transcripts): 

NM_014499.2   NM_198333.1   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_014499  NM_198333  

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_014499
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_014499
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_014499 

Additional cDNA sequence: 

AK292138.1 AK313218.1 BC051875.1 BC095498.1 

4 DOTS entries:

DT.100747872  DT.423965  DT.95365580  DT.121312156 

18 AceView cDNA sequences:

NM_014499 AA211831 NM_198333 BC051875 CD639881 BF795250 CD641054 BI907046 
BI905912 BU429177 CF147798 AA747912 AI540818 AI922752 AA210739 AW499818 
BG196295 AW976214 

highest scoring ESTs for P2RY10:

AA210739 AA211831 AA368850 AA747912 AI540818 AI922752 AW499818 AW962625 AW976214 BC051875 

Unigene Cluster for P2RY10:

Purinergic receptor P2Y, G-protein coupled, 10
Hs.296433  [show with all ESTs]
Unigene Representative Sequence: NM_014499


GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for P2RY10

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1:              -                                             
SP2:                          -                                 
SP3:              -     -                                       
SP4:              -           -                                 
SP5:              -     -     -                                 

About this scheme

ECgene alternative splicing isoforms for P2RY10

2 Ensembl transcripts including schematic representations:
ENST00000171757  ENST00000395516  

Expression
for P2RY10

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

P2RY10 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for P2RY10

1 / 2 / 3

5 probe-sets matching P2RY10 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
358_at2, 3 U95-A 1 1.00 1.00 0.88 1.26 AF000545 0.20 1.00 0.72 1

36413_at2, 3 U95-A 1 1.00 1.00 0.93 0.75 Z82200 0.20 1.00 0.72 1

214615_at2, 3 U133-A 1 0.82 1.00 -- -- NM_014499 0.60 1.00 0.82 1

1553856_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

214615_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
GeneDecks  P2RY10 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: AGCAAGGAGA

SOURCE GeneReport for Unigene cluster: Hs.296433

Expression variation in blood from EXPOLDB for P2RY10

UniProtKB/Swiss-Prot: P2Y10_HUMAN, O00398
Tissue specificity: Weakly expressed in blood leukocytes

Orthologs
for P2RY10

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for P2RY10 gene from 5/6 species (see all 6 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 P2RY101   -- purinergic receptor P2Y, G-protein coupled, 10 90.01(n)
90.21(a)		 491980  XM_549100.1  XP_549100.1 
cow
(Bos taurus)		 P2RY101   -- purinergic receptor P2Y, G-protein coupled, 10 89.09(n)
89.6(a)		 515172  NM_001075699.1  NP_001069167.1 
rat
(Rattus norvegicus)		 P2ry101   -- purinergic receptor P2Y, G-protein coupled 10 85.27(n)
85.37(a)		 317219  XM_228500.4  XP_228500.3 
mouse
(Mus musculus)		 P2ry101, 5 X5
 purinergic receptor P2Y, G-protein coupled 101, 5 85.58(n)1
86.5(a)1		 788261  NM_172435.31  NP_766023.11 
 AI1537305  AK0200015  (see all 10)
chicken
(Gallus gallus)		 RCJMB04_6i221   -- purinergic receptor P2Y, G-protein coupled, 10 68.37(n)
68.69(a)		 422148  XM_420149.2  XP_420149.2 
About this table        Species with no ortholog for P2RY10

ENSEMBL Gene Tree for P2RY10

Paralogs
for P2RY10

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for P2RY10 gene
LPAR42  P2RY52  GPR1742  LPAR52  

Pseudogenes
1 related pseudogene


SNPs/Variants
for P2RY10

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/84 NCBI SNPs in P2RY10 are shown (see all 84 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 41)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr X posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs5367891,2
A,C,F,H78087017(-) GAGGGC/TAAAGA 2 -- ng51 tfbs310Minor allele frequency- T:0.12NA EA EU WA 809
rs66188681,2
C,F,H78102680(+) TGGCTA/CACCTT 2 N/H mis111Minor allele frequency- C:0.25EU EA WA NA 857
rs10234651,2
C,F,H78104115(-) GAAAGA/TTTAGA 2 -- ng3115Minor allele frequency- N:0.00NA EA EU WA 1096
rs27422061,2
A,C,F,H78090430(-) GAATAT/CCTAGA 2 -- int111Minor allele frequency- C:0.26EU EA WA NA 920
rs28585751,2
C,F,H,O78089897(-) CCAGAA/CTGTCC 2 -- int17Minor allele frequency- C:0.05EU EA WA NA 528
rs59121981,2
A,C,F,H78102257(+) TGAGGC/TTAAAT 2 -- int111Minor allele frequency- T:0.26EU EA WA NA 768
rs5270981,2
C,F,H78097044(+) AGGTCG/ACTAGG 2 -- int14Minor allele frequency- A:0.03EU EA WA 404
rs9649401,2
C,F,H78094937(-) AACACG/ACATAA 2 -- int17Minor allele frequency- A:0.01NA EA MN EU WA 553
rs117955791,2
C,F,H78100717(+) agctcA/Cgtttt 2 -- int14Minor allele frequency- C:0.22EU EA WA 418
rs28585641,2
H,O78097998(-) TTCTAT/CGGAGA 2 -- int14Minor allele frequency- C:0.00EU EA WA 418
About this table

HapMap Linkage Disequilibrium images for P2RY10 (up to first 250kb)

Disorders & Mutations
for P2RY10

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 OMIM: 300529

Medical News
for P2RY10

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for P2RY10

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

8 PubMed articles for P2RY10 gene:

Search for P2RY10

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing P2RY10

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 27334 HGNC: 19906 AceView: P2RY10 Ensembl:ENSG00000078589 euGenes: HUgn27334
ECgene: P2RY10 H-InvDB: P2RY10

Other Databases showing P2RY10

(According to HUGE)
About This Section

   --

Specialized Databases showing P2RY10

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for P2RY10

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for P2RY10

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for P2RY10:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



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  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for P2RY10-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
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 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for P2RY10 Antibodies for P2RY10
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for P2RY10 Small molecules for P2RY10
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant Proteins
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 Antibodies (P2Y10)
 Search OriGene for P2RY10
 Tocris compounds for P2RY10




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for P2RY10

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