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Aliases for P2RY10 Gene

Aliases for P2RY10 Gene

  • Purinergic Receptor P2Y10 2 3 5
  • Purinergic Receptor P2Y, G-Protein Coupled, 10 2 3
  • P2Y-Like Receptor 3 4
  • P2Y10 3 4
  • G-Protein Coupled Purinergic Receptor P2Y10 3
  • Putative P2Y Purinoceptor 10 3
  • LYPSR2 3

External Ids for P2RY10 Gene

Previous GeneCards Identifiers for P2RY10 Gene

  • GC0XP075162
  • GC0XP076242
  • GC0XP076956
  • GC0XP078006
  • GC0XP078087
  • GC0XP078200
  • GC0XP071781

Summaries for P2RY10 Gene

Entrez Gene Summary for P2RY10 Gene

  • The protein encoded by this gene belongs to the family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. There is a pseudogene for this gene nearby on chromosome X. Multiple alternatively spliced transcripts have been observed. [provided by RefSeq, Apr 2016]

GeneCards Summary for P2RY10 Gene

P2RY10 (Purinergic Receptor P2Y10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and RET signaling. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled purinergic nucleotide receptor activity. An important paralog of this gene is GPR174.

UniProtKB/Swiss-Prot for P2RY10 Gene

  • Putative receptor for purines coupled to G-proteins.

Tocris Summary for P2RY10 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RY10 Gene

Genomics for P2RY10 Gene

Regulatory Elements for P2RY10 Gene

Enhancers for P2RY10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XF079142 1.4 FANTOM5 Ensembl ENCODE 6.4 +205.4 205385 15.5 TBP MXI1 TBL1XR1 MAX YBX1 ZBTB40 RELA POLR2A EGR1 ZNF366 ITM2A P2RY10 GPR174 ZCCHC5 LPAR4 GC0XM079072
GH0XF079106 1.4 FANTOM5 Ensembl ENCODE 6.4 +163.1 163083 3.8 TBP ZNF146 ZNF280D MTA2 JUNB TBX21 EP300 GABPA RELA TARDBP ITM2A GPR174 P2RY10 LPAR4 GC0XM079072
GH0XF078942 1.4 FANTOM5 Ensembl ENCODE 3.2 +1.5 1542 8.9 TBP PKNOX1 TBL1XR1 WRNIP1 SIN3A RAD21 RFX5 SCRT2 ZNF280D SMAD5 ITM2A TAF9B P2RY10 GC0XM078915
GH0XF079138 1.3 FANTOM5 Ensembl ENCODE 3.3 +194.0 194017 2.3 SRF TBP MTA2 TAL1 BMI1 TBX21 EP300 RELA ARID1B POLR2A ITM2A P2RY10 GPR174 GC0XM079072
GH0XF078922 1.1 FANTOM5 ENCODE 3.6 -22.2 -22177 1.7 TBP TBL1XR1 CHD4 EBF1 RELA CBX5 POLR2A EED NFE2 ETV6 ITM2A P2RY10 MIR4328
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around P2RY10 on UCSC Golden Path with GeneCards custom track

Genomic Location for P2RY10 Gene

78,945,332 bp from pter
78,963,727 bp from pter
18,396 bases
Plus strand

Genomic View for P2RY10 Gene

Genes around P2RY10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY10 Gene

Proteins for P2RY10 Gene

  • Protein details for P2RY10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative P2Y purinoceptor 10
    Protein Accession:
    Secondary Accessions:
    • D3DTE5
    • Q4VBN7
    • Q86V16

    Protein attributes for P2RY10 Gene

    339 amino acids
    Molecular mass:
    38774 Da
    Quaternary structure:
    No Data Available

neXtProt entry for P2RY10 Gene

Post-translational modifications for P2RY10 Gene

  • Glycosylation at Asn 16, Asn 26, and Asn 178
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY10 Gene

No data available for DME Specific Peptides for P2RY10 Gene

Domains & Families for P2RY10 Gene

Gene Families for P2RY10 Gene

Protein Domains for P2RY10 Gene

Suggested Antigen Peptide Sequences for P2RY10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY10: view

Function for P2RY10 Gene

Molecular function for P2RY10 Gene

UniProtKB/Swiss-Prot Function:
Putative receptor for purines coupled to G-proteins.

Gene Ontology (GO) - Molecular Function for P2RY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity IBA --
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY10: view
genes like me logo Genes that share phenotypes with P2RY10: view

Animal Model Products

  • Taconic Biosciences Mouse Models for P2RY10

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for P2RY10 Gene

Localization for P2RY10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY10 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RY10 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for P2RY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA,TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with P2RY10: view

Pathways & Interactions for P2RY10 Gene

genes like me logo Genes that share pathways with P2RY10: view

Gene Ontology (GO) - Biological Process for P2RY10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0035025 positive regulation of Rho protein signal transduction IBA --
GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway IEA --
GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IBA --
genes like me logo Genes that share ontologies with P2RY10: view

No data available for SIGNOR curated interactions for P2RY10 Gene

Drugs & Compounds for P2RY10 Gene

(7) Drugs for P2RY10 Gene - From: DGIdb, IUPHAR, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MC-1 Investigational Pharma 0
JTE-013 Pharma Antagonist 0
LPA Pharma Agonist 0
Sphingosine-1-phosphate Pharma Full agonist, Agonist endogenous second messenger and ligand for S1PR1, Endogenous agonist at S1P1-5 0

(4) Additional Compounds for P2RY10 Gene - From: IUPHAR and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
dioctanoy?aelglycerol?ae pyrophos?aephate
AR-C 118925XX
PPTN hydrochloride
SAR 216471 hydrochloride

(5) Tocris Compounds for P2RY10 Gene

Compound Action Cas Number
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 475193-31-8
AR-C 118925XX Selective, competitive P2Y2 receptor antagonist 216657-60-2
MRS 2500 tetraammonium salt Extremely potent and selective P2Y1 antagonist 630103-23-0
PPTN hydrochloride High affinity and selective P2Y14 antagonist
SAR 216471 hydrochloride Potent P2Y12 antagonist; orally available 1279829-64-9
genes like me logo Genes that share compounds with P2RY10: view

Transcripts for P2RY10 Gene

Unigene Clusters for P2RY10 Gene

Purinergic receptor P2Y, G-protein coupled, 10:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: -
SP2: -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for P2RY10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for P2RY10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for P2RY10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY10 Gene

This gene is overexpressed in Whole Blood (x5.6).

Protein differential expression in normal tissues from HIPED for P2RY10 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for P2RY10 Gene

Protein tissue co-expression partners for P2RY10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of P2RY10 Gene:


SOURCE GeneReport for Unigene cluster for P2RY10 Gene:


mRNA Expression by UniProt/SwissProt for P2RY10 Gene:

Tissue specificity: Weakly expressed in blood leukocytes.
genes like me logo Genes that share expression patterns with P2RY10: view

Orthologs for P2RY10 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY10 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia P2RY10 34 35
  • 90.21 (n)
(Bos Taurus)
Mammalia P2RY10 34 35
  • 89.09 (n)
(Mus musculus)
Mammalia P2ry10 34 16 35
  • 85.42 (n)
(Rattus norvegicus)
Mammalia P2ry10 34
  • 85.42 (n)
(Monodelphis domestica)
Mammalia P2RY10 35
  • 75 (a)
(Gallus gallus)
Aves P2RY10 34
  • 68.37 (n)
-- 35
  • 67 (a)
-- 35
  • 57 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 54 (a)
-- 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry10 34
  • 62.19 (n)
(Danio rerio)
Actinopterygii p2ry10 34 35
  • 59.14 (n)
Species where no ortholog for P2RY10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY10 Gene

Gene Tree for P2RY10 (if available)
Gene Tree for P2RY10 (if available)

Paralogs for P2RY10 Gene

(9) SIMAP similar genes for P2RY10 Gene using alignment to 1 proteins: Pseudogenes for P2RY10 Gene

genes like me logo Genes that share paralogs with P2RY10: view

Variants for P2RY10 Gene

Sequence variations from dbSNP and Humsavar for P2RY10 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs1005490 -- 78,944,496(-) TGGGA(A/T)GATTG upstream-variant-2KB
rs1023465 -- 78,961,962(-) GAAAG(A/T)TTAGA utr-variant-3-prime
rs112282775 -- 78,948,804(-) AAAAA(C/T)GAACA intron-variant
rs11288553 -- 78,955,178(+) CAACA(-/C)TGAGG intron-variant
rs11386282 -- 78,955,293(+) CTCAA(-/G/GGG/GGT)GGTTG intron-variant

Variation tolerance for P2RY10 Gene

Residual Variation Intolerance Score: 26.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 6.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RY10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for P2RY10 Gene

Disorders for P2RY10 Gene

Relevant External Links for P2RY10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for P2RY10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for P2RY10 Gene

Publications for P2RY10 Gene

  1. Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells. (PMID: 11004484) Adrian K. … Ogilvie A. (Biochim. Biophys. Acta 2000) 2 3 4 64
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Receptors for purines and pyrimidines. (PMID: 9755289) Ralevic V. … Burnstock G. (Pharmacol. Rev. 1998) 2 3 64
  5. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. (PMID: 24602016) Kihara Y. … Chun J. (Br. J. Pharmacol. 2014) 3 64

Products for P2RY10 Gene

Sources for P2RY10 Gene

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