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P2RY1 Gene

protein-coding   GIFtS: 64
GCID: GC03P152552

Purinergic Receptor P2Y, G-Protein Coupled, 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Purinergic Receptor P2Y, G-Protein Coupled, 11 2     P2Y Purinoceptor 12
P2Y12 3 5     Platelet ADP Receptor2
ATP Receptor2 3     Purinergic Receptor3
P2 Purinoceptor Subtype Y12     

External Ids:    HGNC: 85391   Entrez Gene: 50282   Ensembl: ENSG000001698607   OMIM: 6011675   UniProtKB: P479003   

Export aliases for P2RY1 gene to outside databases

Previous GC identifers: GC03P149530 GC03P153397 GC03P153834 GC03P153873 GC03P154035 GC03P149943


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for P2RY1 Gene:
The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor
subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and
uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to
ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet
shape, and probably to platelet aggregation. (provided by RefSeq, Jul 2008)

GeneCards Summary for P2RY1 Gene:
P2RY1 (purinergic receptor P2Y, G-protein coupled, 1) is a protein-coding gene. Diseases associated with P2RY1 include venous insufficiency, and extrapulmonary tuberculosis. GO annotations related to this gene include scaffold protein binding and protein heterodimerization activity. An important paralog of this gene is OXGR1.

UniProtKB/Swiss-Prot: P2RY1_HUMAN, P47900
Function: Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to
mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and
probably to platelet aggregation

summary for P2RY1 Gene:
P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine
nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13
and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10
receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4
receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13
and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades
including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They
have diverse physiological roles including regulation of platelet aggregation, muscle contraction,
neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY1 Gene

PharmGKB "VIP" summary for P2RY1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the P2RY1 gene promoter:
         AML1a   Nkx2-2   SREBP-1c   SREBP-1b   SREBP-1a   FOXJ2 (long isoform)   FOXJ2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidP2RY1 promoter sequence
   Search Chromatin IP Primers for P2RY1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat P2RY1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.2   Ensembl cytogenetic band:  3q25.2   HGNC cytogenetic band: 3q25.2

P2RY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P2RY1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P152552:  view genomic region     (about GC identifiers)

Start:
152,552,736 bp from pter      End:
152,555,845 bp from pter
Size:
3,110 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: P2RY1_HUMAN, P47900 (See protein sequence)
Recommended Name: P2Y purinoceptor 1  
Size: 373 amino acids; 42072 Da
1 PDB 3D structure from and Proteopedia for P2RY1:
1Y36 (3D)    

Explore the universe of human proteins at neXtProt for P2RY1: NX_P47900

Explore proteomics data for P2RY1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn11, Asn27, Asn113, Asn197
  • Modification sites at PhosphoSitePlus

  • See P2RY1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002554.1  
    ENSEMBL proteins: 
     ENSP00000304767  
    Reactome Protein details: P47900

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    P2R: Purinergic receptors
    P2RY: GPCR / Class A : Purinergic receptors, P2Y

    IUPHAR Guide to PHARMACOLOGY protein family classification: P2Y1 receptor
    P2Y receptors

    3 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000142 P2Y1_rcpt
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P47900

    ProtoNet protein and cluster: P47900

    2 Blocks protein domains:
    IPB000142 P2Y purinoceptor signature
    IPB002286 P2 purinoceptor signature


    UniProtKB/Swiss-Prot: P2RY1_HUMAN, P47900
    Similarity: Belongs to the G-protein coupled receptor 1 family


    P2RY1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P2RY1_HUMAN, P47900
    Function: Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to
    mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and
    probably to platelet aggregation
    Induction: Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion
    mobilization and shape change in platelets

         Genatlas biochemistry entry for P2RY1:
    purinoceptor,P2Y type 1,group 4,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly
    responding to 2 methylthio-ADP,G protein coupled receptor superfamily

         Gene Ontology (GO): Selected molecular function terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS8630005
    GO:0004930G-protein coupled receptor activity ----
    GO:0005515protein binding IPI9671706
    GO:0005524ATP binding IEA--
    GO:0031686A1 adenosine receptor binding IEA--
         
    P2RY1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for P2RY1:
     Decreased melanin production 

         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for P2ry1):
     hematopoietic system  homeostasis/metabolism 

    P2RY1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for P2RY1: P2ry1tm1Lex P2ry1tm1Bhk P2ry1tm1Gac

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for P2RY1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for P2RY1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for P2RY1

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    1 qRT-PCR Assays for microRNA that regulate P2RY1:
    hsa-miR-576-3p
    SwitchGear 3'UTR luciferase reporter plasmidP2RY1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P2RY1_HUMAN, P47900: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytoskeleton3
    extracellular2

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS8630005
    GO:0016021integral component of membrane ----
    GO:0016323basolateral plasma membrane IEA--
    GO:0016324apical plasma membrane IEA--

    P2RY1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for P2RY1 About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    2Nucleotide-like (purinergic) receptors
    Nucleotide GPCRs0.00
    P2Y receptors0.00
    Nucleotide-like (purinergic) receptors
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5ADP signalling through P2Y purinoceptor 12
    Signal amplification0.79
    ADP signalling through P2Y purinoceptor 10.79

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for P2RY1
        P2Y Receptor Signaling

    1 GeneGo (Thomson Reuters) Pathway for P2RY1
        Signal transduction IP3 signaling

    2 BioSystems Pathways for P2RY1
        GPCRs, Class A Rhodopsin-like
    Nucleotide GPCRs

    3 Reactome Pathways for P2RY1
        P2Y receptors
    ADP signalling through P2Y purinoceptor 1
    G alpha (q) signalling events

    1 PharmGKB Pathway for P2RY1
        Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

    2 Kegg Pathways  (Kegg details for P2RY1):
        Rap1 signaling pathway
    Neuroactive ligand-receptor interaction


    P2RY1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for P2RY1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for P2RY1 (P479001, 2, 3 ENSP000003047674) via UniProtKB, MINT, STRING, and/or I2D (see all 127)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SLC9A3R1O147451, 2, 3, ENSP000002626134EBI-8677223,EBI-349787 MINT-1796624 MINT-1796574 I2D: score=4 STRING: ENSP00000262613
    ADORA1P305423, ENSP000003085494I2D: score=3 STRING: ENSP00000308549
    SLC9A3R2Q155993, ENSP000004080054I2D: score=1 STRING: ENSP00000408005
    ADRBK1ENSP000003122624STRING: ENSP00000312262
    AGTR1ENSP000002734304STRING: ENSP00000273430
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001934positive regulation of protein phosphorylation ISS--
    GO:0001973adenosine receptor signaling pathway ----
    GO:0007166cell surface receptor signaling pathway TAS8630005
    GO:0007186G-protein coupled receptor signaling pathway ISS--
    GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA--

    P2RY1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for P2RY1 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    MRS 2365Highly potent and selective P2Y1 agonist[436847-09-5]
    alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist[7292-42-4]
    UTPgammaS trisodium saltSelective P2Y2/4 agonist[1266569-94-1]
    MRS 2500 tetraammonium saltExtremely potent and selective P2Y1 antagonist[630103-23-0]
    MRS 2179 tetrasodium saltSelective P2Y1 antagonist[101204-49-3]

    1 HMDB Compound for P2RY1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected IUPHAR Ligands for P2RY1 (P2Y1 receptor) (see all 29)    About this table
    LigandTypeActionAffinityPubmed IDs
    MRS2365
    AgonistAgonist9.415345752
    [32P]MRS2500
    AntagonistAntagonist9.416299552
    MRS2500
    AntagonistAntagonist8.8 - 9.114584948 15476670
    BMS compound 4c
    AntagonistAntagonist8.223668989
    BMS compound 16 [PMID:23368907]
    AntagonistAntagonist8.223368907
    [3H]MRS2279
    AntagonistAntagonist8.112391289
    2',3'-ddATP
    AgonistPartial agonist89154346
    Pfizer compound 67 [PMID:18445527]
    AntagonistAntagonist818445527
    MRS2279
    AntagonistAntagonist7.912391289
    dATPalphaS
    AgonistPartial agonist7.79154346

    Selected Novoseek inferred chemical compound relationships for P2RY1 gene (see all 40)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mrs2179 94.4 10 14644082 (1), 15265806 (1), 12807993 (1), 17459368 (1) (see all 10)
    2-mesadp 91.8 4 11502873 (2), 16795051 (1), 11877327 (1)
    adp 87.7 134 14644082 (3), 15514209 (3), 18174464 (3), 12189014 (3) (see all 77)
    3'-phosphoadenosine 5'-phosphate 87.7 8 9858246 (1), 15203713 (1), 11422381 (1), 12871420 (1) (see all 6)
    cangrelor 87.3 6 15668190 (1), 17459368 (1), 18480058 (1), 18574670 (1) (see all 6)
    a3p5ps 87 3 12189014 (2), 11502873 (1)
    2',5'-adp 84.6 6 9858246 (1), 15668190 (1), 11054084 (1), 11172816 (1) (see all 5)
    udpbetas 82.5 1 10869373 (1)
    bzatp 81.8 2 18048695 (1), 16373435 (1)
    ppads 77.4 4 9134216 (2), 11159687 (1), 12694404 (1)

    1 PharmGKB related drug/compound annotation for P2RY1 gene    About this table
    Drug/compound PharmGKB Annotation
    aspirinCA  



    P2RY1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for P2RY1 gene: 
    NM_002563.3  

    Unigene Cluster for P2RY1:

    Purinergic receptor P2Y, G-protein coupled, 1
    Hs.654526  [show with all ESTs]
    Unigene Representative Sequence: NM_002563
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000305097(uc003ezq.3)

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      QuantiTect SYBR Green Assays in human, mouse, rat P2RY1
      QuantiFast Probe-based Assays in human, mouse, rat P2RY1

    Additional mRNA sequence: 

    AF018284.1 AK313920.1 AY136752.1 BC074784.2 BC074785.2 U42029.1 U42030.1 Z49205.1 

    1 DOTS entry:

    DT.309061 

    16 AceView cDNA sequences:

    AY136752 AF018284 BX281527 AU100240 BC074785 AU107922 U42030 U42029 
    NM_002563 BC074784 AI820551 Z49205 BX497359 CF147800 AW753128 T65835 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    P2RY1 expression in normal human tissues (normalized intensities)      P2RY1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    P2RY1 Expression
    About this image


    P2RY1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
     
     Brain (Nervous System)
             Adult Endothelial Cells Blood Brain Barrier
    P2RY1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    P2RY1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654526
        Pathway & Disease-focused RT2 Profiler PCR Array including P2RY1: 
              G Protein Coupled Receptors 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for P2RY1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia P2ry11 , 5 purinergic receptor P2Y, G-protein coupled 11, 5 87.13(n)1
    94.91(a)1
      3 (29.24 cM)5
    184411  NM_001282016.11  NP_001268945.11 
     610027955 
    chicken
    (Gallus gallus)
    Aves P2RY11 purinergic receptor P2Y, G-protein coupled, 1 77.9(n)
    86.19(a)
      396275  NM_205333.1  NP_990664.1 
    lizard
    (Anolis carolinensis)
    Reptilia P2RY16
    purinergic receptor P2Y, G-protein coupled, 1
    86(a)
    1 ↔ 1
    3(17226907-17227959)
    African clawed frog
    (Xenopus laevis)
    Amphibia p2ry1-A2 P2Y1 nucleotide receptor 78.8(n)    AF432354.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000039221 P2Y purinoceptor 1-like 72.04(n)
    74.49(a)
      100003922  XM_001343319.4  XP_001343355.1 


    ENSEMBL Gene Tree for P2RY1 (if available)
    TreeFam Gene Tree for P2RY1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for P2RY1 gene
    OXGR12  P2RY42  GPR172  P2RY62  GPR1742  LPAR62  LPAR52  CYSLTR12  
    GPR1832  LPAR42  CYSLTR22  P2RY22  SUCNR12  P2RY102  PTAFR2  
    Selected SIMAP similar genes for P2RY1 using alignment to 1 protein entry:     P2RY1_HUMAN(see all similar genes):
    OXGR1    GPR17    P2RY4    CYSLTR2    KPG_011    CYSLTR1
    P2RY2    LPAR6    CXCR6    LPAR4    SUCNR1    CCR1
    GPR183    GPR4    P2RY8    F2RL1    F2RL2    GPR174

    P2RY1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for P2RY1 (see all 133)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs775988981,2
    C,F--152530580(+) ACAGCG/ACCCAG 1 -- us2k12Minor allele frequency- A:0.06NA EA 240
    rs569590081,2
    C,F--152530615(+) TTTTTT/AAAAAA 1 -- us2k12Minor allele frequency- A:0.38WA 120
    rs92898761,2
    C,F,H--152530689(+) ACTTAA/TTGGTA 1 -- us2k15Minor allele frequency- T:0.02NS EA NA 540
    rs1426488081,2
    --152530704(+) GACTAA/CGTGTA 1 -- us2k10--------
    rs1501842821,2
    --152530705(+) ACTAAA/GTGTAC 1 -- us2k10--------
    rs593892421,2
    F--152530719(+) TCAAAA/GCACTC 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs168646051,2
    C,F,H--152530779(+) TTGCCT/CAGGTT 1 -- us2k111Minor allele frequency- C:0.08NA NS EA WA 914
    rs1870495531,2
    --152530912(+) ATCAAA/CCAATA 1 -- us2k10--------
    rs14390261,2
    C,F,A,H--152531021(+) ACACTG/CTTTAC 1 -- us2k110Minor allele frequency- C:0.18NS EA WA NA CSA 667
    rs1439838301,2
    C--152531042(+) TACTC-/TTGTT 
            
    TTATT
    1 -- us2k10--------

    HapMap Linkage Disequilibrium report for P2RY1 (152552736 - 152555845 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for P2RY1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing P2RY1
    DNA2.0 Custom Variant and Variant Library Synthesis for P2RY1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601167    OMIM disorders: --

    Selected diseases for P2RY1 (see all 31):    About MalaCards
    venous insufficiency    extrapulmonary tuberculosis    smallpox    erythrocytosis
    hirschsprung's disease    osteosarcoma    thyroid cancer    pertussis
    tuberculosis    vascular disease    pneumonia    malaria
    cystic fibrosis    periodontitis    coronary artery disease    astrocytoma
    endotheliitis    ischemia    myocardial infarction    thyroiditis


    P2RY1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    6 Novoseek inferred disease relationships for P2RY1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    astrocytoma 52.4 9 15913566 (1), 11985476 (1), 9134216 (1), 15602005 (1) (see all 6)
    thrombosis 40.7 4 12933533 (1), 15203715 (1), 16234484 (1), 10960076 (1)
    glioma 16.4 7 11159687 (3), 14718252 (2), 11904146 (2)
    tumors 0.833 2 12880424 (1), 20063989 (1)
    cardiovascular diseases 0 1 14645014 (1)
    osteosarcoma 0 1 10318853 (1)

    Genetic Association Database (GAD): P2RY1
    Human Genome Epidemiology (HuGE) Navigator: P2RY1 (12 documents)

    Export disorders for P2RY1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for P2RY1 gene, integrated from 10 sources (see all 273):
    (articles sorted by number of sources associating them with P2RY1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and chromosomal localization of the human P2Y1 purinoceptor. (PubMed id 8579591)1, 2, 3, 9 Ayyanathan K....Kunapuli S.P. (Biochem. Biophys. Res. Commun. 1996)
    2. Frequency of genetic polymorphisms of COX1, GPIIIa and P2Y1 in a Chinese population and association with attenuated response to aspirin. (PubMed id 17559347)1, 4, 9 Li Q....Zhou H.H. (Pharmacogenomics 2007)
    3. Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP. (PubMed id 15514209)1, 4, 9 Hetherington S.L....Samani N.J. (Arterioscler. Thromb. Vasc. Biol. 2005)
    4. Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel. (PubMed id 16581111)1, 4, 9 Lev E.I....Kleiman N.S. (Thromb. Res. 2007)
    5. Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor. (PubMed id 8666290)1, 2, 9 Leon C.... Gachet C. (Gene 1996)
    6. Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3. (PubMed id 19637098)1, 4, 9 Storey R.F....Armstrong M. (Platelets 2009)
    7. Genetics of platelet reactivity in normal, healthy individuals. (PubMed id 19740098)1, 4, 9 Kunicki T.J....Nugent D.J. (J. Thromb. Haemost. 2009)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment. (PubMed id 20056178)1, 4 Segat L....Crovella S. (Vaccine 2010)
    10. Besides CYP2C19*2, the variant allele CYP2C9*3 is associated with higher on-clopidogrel platelet reactivity in patients on dual antiplatelet therapy undergoing elective coronary stent implantation. (PubMed id 19934793)1, 4 Harmsze A....Deneer V.H. (Pharmacogenet. Genomics 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5028 HGNC: 8539 AceView: P2RY1 Ensembl:ENSG00000169860 euGenes: HUgn5028
    ECgene: P2RY1 Kegg: 5028 H-InvDB: P2RY1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for P2RY1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for P2RY1 gene:
    Search GeneIP for patents involving P2RY1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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