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P2RY1 Gene

protein-coding GIFtS: 63

GC03P154035

purinergic receptor P2Y, G-protein coupled, 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
P2Y1 ^¹, ², ³, ⁵

Descriptions
ATP receptor ^², ³
P2 purinoceptor subtype Y1 ^²
P2Y purinoceptor 1 ^²
Purinergic receptor ^³
platelet ADP receptor ^²
purinergic receptor P2Y, G-protein coupled, 1 ^²
purinergic receptor P2Y1 ^²

External Ids
HGNC: 8539¹
Entrez Gene: 5028²
UniProtKB: P47900³
Ensembl: ENSG00000169860⁷

Search outside databases for aliases for P2RY1 gene

Previous GC identifers: GC03P149530 GC03P153397 GC03P153834 GC03P153873

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for P2RY1:

The product of this gene belongs to the family of G-protein coupled receptors. This family has

several receptor subtypes with different pharmacological selectivity, which overlaps in some

cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for

extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular

calcium ions via activation of phospholipase C, a change in platelet shape, and probably to

platelet aggregation. [provided by RefSeq]

UniProtKB/Swiss-Prot: P2RY1_HUMAN, P47900

Function: Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding

to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a

change in platelet shape, and probably to platelet aggregation

Gene Wiki entry for P2RY1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the P2RY1 gene

Entrez Gene cytogenetic band: 3q25.2 Ensembl cytogenetic band: 3q25.2 HGNC cytogenetic band: 3q25.2

P2RY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P154035: (about GC identifiers)

Start:	154,035,426 bp from pter
End:	154,038,535 bp from pter
Size:	3,110 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_005612.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: P2RY1_HUMAN, P47900 (See protein sequence)

Recommended Name: P2Y purinoceptor 1

Size: 373 amino acids; 42072 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

1Y36 (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002554.1

ENSEMBL proteins:

ENSP00000304767 ENSP00000385645

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant P2RY1 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (P2Y1)
	Human Recombinant Proteins from Abnova (P2RY1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	8630005

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Antibodies for P2RY1:

	Invitrogen Antibodies for P2RY1
	Millipore Mono- and Polyclonal Antibodies for the study of P2RY1
	Sigma-Aldrich Antibodies for P2RY1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (P2Y1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for P2RY1

Assays for P2RY1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P47900

ProtoNet protein and cluster: P47900

2 Blocks protein families:

IPB000142 P2Y purinoceptor signature

IPB002286 P2 purinoceptor signature

UniProtKB/Swiss-Prot: P2RY1_HUMAN, P47900

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RY1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RY1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002563

Applied Biosystems Silencer® siRNAs for P2RY1

Sigma-Aldrich siRNA and siRNA Panels for P2RY1

Sigma-Aldrich shRNA Panels and shRNA for P2RY1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for P2RY1
		Millipore Clones for the Expression of P2RY1

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002563
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002563
untagged cDNA clone in CMV expression vector: NM_002563

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002563

UniProtKB/Swiss-Prot: P2RY1_HUMAN, P47900

Function: Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding

to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a

change in platelet shape, and probably to platelet aggregation

Induction: Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These

inhibit calcium ion mobilization and shape change in platelets

Genatlas biochemistry entry for P2RY1:

purinoceptor,P2Y type 1,group 4,metabotropic,expressed in bone,osteoblastic and brain cell

lines,predominantly responding to 2 methylthio-ADP,G protein coupled receptor superfamily

2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for P2ry1):

hematopoietic system

homeostasis/metabolism

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	8630005
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0045028	purinergic nucleotide receptor activity, G-protein coupled	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for P2RY1 (Your Favorite Gene powered by Ingenuity)

G-Protein Coupled Receptor Signaling

GeneDecks P2RY1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for P2RY1

5/20 Interacting proteins for P2RY1 (P47900² ENSP00000304767³) via UniProtKB, MINT, and/or STRING (see all 20 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC9A3R1	O14745², ENSP00000262613³	MINT-1796624 MINT-1796574 STRING (score=.798)
ENTPD2	ENSP00000347213³	STRING (score=.952)
ADCY2	ENSP00000371971³	STRING (score=.927)
P2RX1	ENSP00000225538³	STRING (score=.922)
ENTPD1	ENSP00000360250³	STRING (score=.905)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007200	activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	TAS	8630005
GO:0007596	blood coagulation	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for P2RY1:

Antagonist Agonist Inhibitor

Compounds for P2RY1 available from Tocris Bioscience

Compound	Action	CAS number
MRS 2365	Highly potent and selective P2Y1 agonist	[436847-09-5]
MRS 2279	Selective, high affinity P2Y1 antagonist	[367909-40-8]
2-Methylthio-ADP trisodium salt	Potent agonist for P2Y1, P2Y12 and P2Y13	[34983-48-7]
MRS 2500 tetraammonium salt	Extremely potent and selective P2Y1 antagonist	[779323-43-2]
MRS 2179 tetrasodium salt	Selective P2Y1 antagonist	[101204-49-3]

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10/25 Novoseek chemical compound relationships for P2RY1 gene (see all 25 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
mrs2179	94.62	9	14644082 (1), 15265806 (1), 12807993 (1), 17459368 (1) (see all 9)
2-mesadp	92.23	4	11502873 (2), 16795051 (1), 11877327 (1)
adp	87.60	118	14644082 (3), 15514209 (3), 18174464 (3), 12189014 (3) (see all 71)
a3p5ps	87.29	3	12189014 (2), 11502873 (1)
2',5'-adp	84.98	6	9858246 (1), 15668190 (1), 11054084 (1), 11172816 (1) (see all 5)
cangrelor	83.95	3	15668190 (1), 17459368 (1), 18480058 (1)
udpbetas	82.86	1	10869373 (1)
2-methylthio-atp	77.62	5	11032896 (1), 9134216 (1), 19303093 (1), 18675894 (1)
atp	74.70	35	9517568 (2), 17187456 (2), 18502966 (2), 18675894 (2) (see all 28)
calcium	58.29	30	11159687 (2), 14718252 (2), 17043813 (2), 16158305 (2) (see all 23)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RY1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RY1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002563

Sigma-Aldrich siRNA and siRNA Panels for P2RY1

Sigma-Aldrich shRNA Panels and shRNA for P2RY1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002563

REFSEQ mRNAs for P2RY1 gene:

NM_002563.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002563

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002563
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002563
                                 untagged cDNA clone in CMV expression vector: NM_002563

Additional cDNA sequence:

AF018284.1 AK313920.1 AY136752.1 BC074784.2 BC074785.2 U42029.1 U42030.1 Z49205.1

1 DOTS entry:

DT.309061

16 AceView cDNA sequences:

U42030 AU107922 AU100240 BC074785 BC074784 AY136752 U42029 AF018284

BX281527 NM_002563 CF147800 AI820551 BX497359 Z49205 AW753128 T65835

highest scoring ESTs for P2RY1:

Z49205 AF018284 AI820551 AU100240 AY136752 BX281527 T65835 U42029 U42030 BC074784

Unigene Cluster for P2RY1:

Purinergic receptor P2Y, G-protein coupled, 1

Hs.654526 [show with all ESTs]

Unigene Representative Sequence: NM_002563

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000305097 ENST00000407427

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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P2RY1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for P2RY1

¹ / ² / ³

3 probe-sets matching P2RY1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33460_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	Z49205	1.00	1.00	1.00	1
207455_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002563	0.60	1.00	0.82	1
207455_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.654526
Expression variation in blood from EXPOLDB for P2RY1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for P2RY1 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	P2RY1¹	--	purinergic receptor P2Y, G-protein coupled, 1	81.62(n) 87.84(a)	449621 NM_001005764.1 NP_001005764.1
chimpanzee (Pan troglodytes)	P2RY1¹	--	purinergic receptor P2Y, G-protein coupled, 1	99.55(n) 99.73(a)	470970 XM_526353.2 XP_526353.1
cow (Bos taurus)	P2RY1¹	--	purinergic receptor P2Y, G-protein coupled, 1	91.87(n) 96.78(a)	281963 NM_174410.2 NP_776835.1
rat (Rattus norvegicus)	P2ry1¹	--	purinergic receptor P2Y, G-protein coupled 1	87.85(n) 95.17(a)	25265 NM_012800.1 NP_036932.1
mouse (Mus musculus)	P2ry1^{1, 5}	3⁵	purinergic receptor P2Y, G-protein coupled 1^{1, 5}	87.13(n)¹ 94.91(a)¹	18441¹ NM_008772.3¹ NP_032798.1¹ AJ245636⁵ AK030759⁵ (see all 11)

About this table Species with no ortholog for P2RY1

ENSEMBL Gene Tree for P2RY1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for P2RY1 gene

P2RY4² P2RY6² P2RY2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/26 NCBI SNPs in P2RY1 are shown (see all 26 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 29)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1439009^1,2	A,C,F,H	154034515(+)	`AATGTA/TGTAAT`	1	--	ng5¹		7		EU EA WA NA	690
	rs1371097^1,2	A,C,F,H	154034880(+)	`ATCTTC/TACAAG`	1	--	ng5¹		4		EU EA WA	418
	rs1439026^1,2	A,C,F,H	154034003(+)	`ACACTG/CTTTAC`	1	--	ng5¹		3		EU EA	298
	rs9289876^1,2	C,F,H	154033671(+)	`ACTTAA/TTGGTA`	1	--	ng5¹		4		EU EA WA	420
	rs16864605^1,2	C,F,H	154033761(+)	`TTGCCT/CAGGTT`	1	--	ng5¹		7		NA EU EA WA	552
	rs16864613^1,2	C,F,H	154038142(+)	`AACACC/GATGAG`	1	--	ut3¹		11		NA EU EA WA	972
	rs3755711^1,2	C	154035615(-)	`CTGTCC/GGGAGT`	1	--	ut5¹ ese³		0	--	--	--	--
	rs701265^1,2	A,C,F,H	154037047(+)	`CTGGTA/GATCAT`	1	V/V	syn¹		9		NA EA EU WA MN	774
	rs1065776^1,2	F	154036318(+)	`CTGGCC/TGGTCC`	1	A/A	syn¹ ese³		2		MN	198
--	rs34274067^1,2	--	154034748(+)	`TTTTT-/TCATTG`	1	--	ng5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for P2RY1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 601167

6 Novoseek disease relationships for P2RY1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
astrocytoma	53.77	9	15913566 (1), 11985476 (1), 9134216 (1), 15602005 (1) (see all 6)
thrombosis	41.04	4	12933533 (1), 15203715 (1), 16234484 (1), 10960076 (1)
glioma	18.68	7	11159687 (3), 14718252 (2), 11904146 (2)
tumors	0.61	1	12880424 (1)
cardiovascular diseases	0.00	1	14645014 (1)
osteosarcoma	0.00	1	10318853 (1)

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Genetic Association Database: P2RY1
Human Genome Epidemiology Navigator: P2RY1 (4 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/233 PubMed articles for P2RY1 gene (see all 233 ):

Cloning and chromosomal localization of the human P2Y1 purinoceptor. (PubMed id 8579591)^{1, 2, 3, 4} Ayyanathan K....Kunapuli S.P. (1996)
Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP. (PubMed id 15514209)^{1, 3, 6} Hetherington S.L....Samani N.J. (2005)
Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor. (PubMed id 8666290)^{1, 3, 4} Leon C.... Gachet C. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. (PubMed id 9442040)^{3, 4} Jin J.... Kunapuli S.P. (1998)
Cloning and tissue distribution of the human P2Y1 receptor. (PubMed id 8630005)^{3, 4} Janssens R....Boeynaems J.-M. (1996)
Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets. (PubMed id 15187029)^{1, 3} Hardy A.R....Poole A.W. (2004)
Distinct roles for protein kinase C isoforms in regulating platelet purinergic receptor function. (PubMed id 16804093)^{1, 3} Mundell S.J....Poole A.W. (2006)
Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system. (PubMed id 12393588)^{1, 3} Nurden P....Nurden A.T. (2003)
ADP stimulates human endothelial cell migration via P2Y1 nucleotide receptor-mediated mitogen-activated protein kinase pathways. (PubMed id 18174464)^{1, 3} Shen J. and DiCorleto P.E. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5028	HGNC: 8539	AceView: P2RY1	Ensembl:ENSG00000169860	euGenes: HUgn5028
ECgene: P2RY1	H-InvDB: P2RY1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for P2RY1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for P2RY1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for P2RY1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for P2RY1		Antibodies for P2RY1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for P2RY1		Small molecules for P2RY1
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Tocris compounds for P2RY1

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P2RY1 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for P2RY1

Summaries
for P2RY1

Genomic Location
for P2RY1

Proteins
for P2RY1

Protein Domains/
Families
for P2RY1

Gene Function
for P2RY1

Pathways & Interactions
for P2RY1

Drugs & Compounds
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Transcripts
for P2RY1

Expression
for P2RY1

Orthologs
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for P2RY1

Search for P2RY1

Genome Databases showing P2RY1

Other Databases showing P2RY1

Specialized Databases showing P2RY1

Licensable Technologies
for P2RY1

Services
for P2RY1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

P2RY1 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor P2RY1

Summariesfor P2RY1

Genomic Locationfor P2RY1

Proteinsfor P2RY1

Protein Domains/Familiesfor P2RY1

Gene Functionfor P2RY1

Pathways & Interactionsfor P2RY1

Drugs & Compoundsfor P2RY1

Transcriptsfor P2RY1

Expression for P2RY1

Orthologsfor P2RY1

Paralogsfor P2RY1

SNPs/Variantsfor P2RY1

Disorders & Mutationsfor P2RY1

Medical Newsfor P2RY1

Publicationsfor P2RY1

Search for P2RY1

Genome Databases showing P2RY1

Other Databases showing P2RY1

Specialized Databases showing P2RY1

Licensable Technologiesfor P2RY1

Servicesfor P2RY1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for P2RY1

Summaries
for P2RY1

Genomic Location
for P2RY1

Proteins
for P2RY1

Protein Domains/
Families
for P2RY1

Gene Function
for P2RY1

Pathways & Interactions
for P2RY1

Drugs & Compounds
for P2RY1

Transcripts
for P2RY1

Expression
for P2RY1

Orthologs
for P2RY1

Paralogs
for P2RY1

SNPs/Variants
for P2RY1

Disorders & Mutations
for P2RY1

Medical News
for P2RY1

Publications
for P2RY1

Licensable Technologies
for P2RY1

Services
for P2RY1