Free for academic non-profit institutions. Other users need a Commercial license

Aliases for P2RY1 Gene

Aliases for P2RY1 Gene

  • Purinergic Receptor P2Y, G-Protein Coupled, 1 2 3
  • P2Y1 3 4 6
  • ATP Receptor 3 4
  • P2 Purinoceptor Subtype Y1 3
  • Platelet ADP Receptor 3
  • Purinergic Receptor 4
  • P2Y Purinoceptor 1 3

External Ids for P2RY1 Gene

Previous GeneCards Identifiers for P2RY1 Gene

  • GC03P149530
  • GC03P153397
  • GC03P153834
  • GC03P153873
  • GC03P154035
  • GC03P152552
  • GC03P149943

Summaries for P2RY1 Gene

Entrez Gene Summary for P2RY1 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY1 Gene

P2RY1 (Purinergic Receptor P2Y, G-Protein Coupled, 1) is a Protein Coding gene. Diseases associated with P2RY1 include extrapulmonary tuberculosis. Among its related pathways are GPCR Pathway and Ras signaling pathway. GO annotations related to this gene include protein heterodimerization activity and scaffold protein binding. An important paralog of this gene is PTAFR.

UniProtKB/Swiss-Prot for P2RY1 Gene

  • Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.

Tocris Summary for P2RY1 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13 and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10 receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4 receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13 and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They have diverse physiological roles including regulation of platelet aggregation, muscle contraction, neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY1 Gene

PharmGKB "VIP" Summary for P2RY1 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for P2RY1 Gene

Genomics for P2RY1 Gene

Regulatory Elements for P2RY1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for P2RY1 Gene

Start:
152,834,693 bp from pter
End:
152,838,056 bp from pter
Size:
3,364 bases
Orientation:
Plus strand

Genomic View for P2RY1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for P2RY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY1 Gene

Proteins for P2RY1 Gene

  • Protein details for P2RY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47900-P2RY1_HUMAN
    Recommended name:
    P2Y purinoceptor 1
    Protein Accession:
    P47900
    Secondary Accessions:

    Protein attributes for P2RY1 Gene

    Size:
    373 amino acids
    Molecular mass:
    42072 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY1 Gene

neXtProt entry for P2RY1 Gene

Proteomics data for P2RY1 Gene at MOPED

Post-translational modifications for P2RY1 Gene

  • Glycosylation at Asn11, Asn27, Asn113, and Asn197
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for P2RY1 Gene

Domains for P2RY1 Gene

Gene Families for P2RY1 Gene

HGNC:
  • P2RY :GPCR / Class A : Purinergic receptors, P2Y
  • P2R :Purinergic receptors
IUPHAR :

Protein Domains for P2RY1 Gene

Suggested Antigen Peptide Sequences for P2RY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47900

UniProtKB/Swiss-Prot:

P2RY1_HUMAN :
  • P47900
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY1: view

Function for P2RY1 Gene

Molecular function for P2RY1 Gene

GENATLAS Biochemistry: purinoceptor,P2Y type 1,group 4,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly responding to 2 methylthio-ADP,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function: Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.
UniProtKB/Swiss-Prot Induction: Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion mobilization and shape change in platelets

Gene Ontology (GO) - Molecular Function for P2RY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004872 receptor activity TAS 8630005
GO:0004930 G-protein coupled receptor activity --
GO:0005515 protein binding IPI 9671706
GO:0005524 ATP binding IEA --
GO:0031686 A1 adenosine receptor binding IEA --
genes like me logo Genes that share ontologies with P2RY1: view

Phenotypes for P2RY1 Gene

MGI mutant phenotypes for P2RY1:
inferred from 2 alleles
GenomeRNAi human phenotypes for P2RY1:
genes like me logo Genes that share phenotypes with P2RY1: view

Animal Models for P2RY1 Gene

MGI Knock Outs for P2RY1:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for P2RY1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for P2RY1 Gene

Localization for P2RY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY1 Gene COMPARTMENTS Subcellular localization image for P2RY1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 3
extracellular 2

Gene Ontology (GO) - Cellular Components for P2RY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 8630005
GO:0009986 cell surface IDA 23382103
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with P2RY1: view

Pathways for P2RY1 Gene

genes like me logo Genes that share pathways with P2RY1: view

Pathways by source for P2RY1 Gene

1 GeneGo (Thomson Reuters) pathway for P2RY1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for P2RY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation ISS --
GO:0001973 adenosine receptor signaling pathway IEA --
GO:0007166 cell surface receptor signaling pathway TAS 8630005
GO:0007186 G-protein coupled receptor signaling pathway ISS --
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA --
genes like me logo Genes that share ontologies with P2RY1: view

Compounds for P2RY1 Gene

(5) Tocris Compounds for P2RY1 Gene

Compound Action Cas Number
alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt P2 agonist [1343364-54-4]
2-Methylthioadenosine diphosphate trisodium salt Potent agonist for P2Y1, P2Y12 and P2Y13 [475193-31-8]
MRS 2179 tetrasodium salt Selective P2Y1 antagonist [1454889-37-2]
MRS 2365 Highly potent and selective P2Y1 agonist [436847-09-5]
MRS 2500 tetraammonium salt Extremely potent and selective P2Y1 antagonist [630103-23-0]

(1) HMDB Compounds for P2RY1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(29) IUPHAR Ligand for P2RY1 Gene

Ligand Type Action Affinity Pubmed IDs
MRS2365 Agonist Agonist 9.4
[32P]MRS2500 Antagonist Antagonist 9.4
MRS2500 Antagonist Antagonist 9.1
BMS compound 4c Antagonist Antagonist 8.2
BMS compound 16 [PMID:23368907] Antagonist Antagonist 8.2
[3H]MRS2279 Antagonist Antagonist 8.1
2,3-ddATP Agonist Partial agonist 8
Pfizer compound 67 [PMID:18445527] Antagonist Antagonist 8
MRS2279 Antagonist Antagonist 7.9
dATPalphaS Agonist Partial agonist 7.7
MRS2298 Antagonist Antagonist 7.5
Pfizer compound 11 [PMID:18445527] Antagonist Antagonist 7.3
GlaxoSmithKline compound 6i [PMID:18926700] Antagonist Antagonist 7.2
MRS2179 Antagonist Antagonist 7.1
MRS2496 Antagonist Antagonist 7.1
2MeSADP Agonist Full agonist 7
MRS2950 Antagonist Antagonist 6.9
GlaxoSmithKline compound 5h [PMID:20542694] Antagonist Antagonist 6.85
2,2-pyridylisatogen tosylate Antagonist Antagonist 6.8
A2P5P Antagonist Antagonist 5.8
ADP Gating inhibitor Antagonist 5.7
adenosine-3-5-bisphosphate Antagonist Antagonist 5.6
2-ClATP Antagonist Antagonist 5.6
ATPgammaS Agonist Full agonist 5.5
PPADS Antagonist Antagonist 5
ADPbetaS Agonist Full agonist 4.5
2MeSATP Agonist Full agonist 4.3
suramin Activator None
ATP Activator None

(40) Novoseek inferred chemical compound relationships for P2RY1 Gene

Compound -log(P) Hits PubMed IDs
mrs2179 94.4 10
2-mesadp 91.8 4
adp 87.7 103
3-phosphoadenosine 5-phosphate 87.7 6
cangrelor 87.3 6

(1) PharmGKB related drug/compound annotations for P2RY1 Gene

Drug/compound Annotation
aspirin CA
genes like me logo Genes that share compounds with P2RY1: view

Transcripts for P2RY1 Gene

mRNA/cDNA for P2RY1 Gene

(16) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for P2RY1 Gene

Purinergic receptor P2Y, G-protein coupled, 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for P2RY1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY1 Gene

No ASD Table

Relevant External Links for P2RY1 Gene

GeneLoc Exon Structure for
P2RY1
ECgene alternative splicing isoforms for
P2RY1

Expression for P2RY1 Gene

mRNA expression in normal human tissues for P2RY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY1 Gene

This gene is overexpressed in Esophagus - Mucosa (6.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for P2RY1 Gene

SOURCE GeneReport for Unigene cluster for P2RY1 Gene Hs.654526

genes like me logo Genes that share expressions with P2RY1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for P2RY1 Gene

Orthologs for P2RY1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY1 35
  • 99.55 (n)
  • 99.73 (a)
P2RY1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia P2RY1 35
  • 91.87 (n)
  • 96.78 (a)
P2RY1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia P2RY1 35
  • 81.53 (n)
  • 87.84 (a)
P2RY1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia P2ry1 35
  • 87.13 (n)
  • 94.91 (a)
P2ry1 16
P2ry1 36
  • 95 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia P2RY1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia P2RY1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2ry1 35
  • 87.85 (n)
  • 95.17 (a)
chicken
(Gallus gallus)
Aves P2RY1 35
  • 77.9 (n)
  • 86.19 (a)
P2RY1 36
  • 86 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia P2RY1 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia p2ry1-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry1 35
  • 75.25 (n)
  • 84.49 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100003922 35
  • 72.04 (n)
  • 74.49 (a)
P2RY1 36
  • 72 (a)
OneToOne
Species with no ortholog for P2RY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY1 Gene

ENSEMBL:
Gene Tree for P2RY1 (if available)
TreeFam:
Gene Tree for P2RY1 (if available)

Paralogs for P2RY1 Gene

genes like me logo Genes that share paralogs with P2RY1: view

Variants for P2RY1 Gene

Sequence variations from dbSNP and Humsavar for P2RY1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs701265 -- 152,836,568(+) CTGGT(A/G)ATCAT reference, synonymous-codon
rs1065776 -- 152,835,839(+) CTGGC(C/T)GGTCC reference, synonymous-codon
rs1371097 -- 152,834,401(+) ATCTT(C/T)ACAAG upstream-variant-2KB
rs1371098 -- 152,834,408(+) CAAGA(C/T)TATTT upstream-variant-2KB
rs1439009 -- 152,834,036(+) AATGT(A/T)GTAAT upstream-variant-2KB

Relevant External Links for P2RY1 Gene

HapMap Linkage Disequilibrium report
P2RY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for P2RY1 Gene

Disorders for P2RY1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for P2RY1 Gene including...

Search for P2RY1 Gene in MalaCards »

(6) Novoseek inferred disease relationships for P2RY1 Gene

Disease -log(P) Hits PubMed IDs
astrocytoma 52.4 6
thrombosis 40.7 4
glioma 16.4 7
tumors 0.833 2
cardiovascular diseases 0 1

Relevant External Links for P2RY1

Genetic Association Database (GAD)
P2RY1
Human Genome Epidemiology (HuGE) Navigator
P2RY1
genes like me logo Genes that share disorders with P2RY1: view

No data available for UniProtKB/Swiss-Prot for P2RY1 Gene

Publications for P2RY1 Gene

  1. Cloning and chromosomal localization of the human P2Y1 purinoceptor. (PMID: 8579591) Ayyanathan K. … Kunapuli S.P. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23
  2. Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor. (PMID: 8666290) Leon C. … Gachet C. (Gene 1996) 3 4 23
  3. Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP. (PMID: 15514209) Hetherington S.L. … Samani N.J. (Arterioscler. Thromb. Vasc. Biol. 2005) 3 23 48
  4. Genetic polymorphisms of the platelet receptors P2Y(12), P2Y(1) and GP IIIa and response to aspirin and clopidogrel. (PMID: 16581111) Lev E.I. … Kleiman N.S. (Thromb. Res. 2007) 3 23 48
  5. Frequency of genetic polymorphisms of COX1, GPIIIa and P2Y1 in a Chinese population and association with attenuated response to aspirin. (PMID: 17559347) Li Q. … Zhou H.H. (Pharmacogenomics 2007) 3 23 48

Products for P2RY1 Gene

Sources for P2RY1 Gene

Back to Top

Content