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Aliases for P2RY1 Gene

Aliases for P2RY1 Gene

  • Purinergic Receptor P2Y1 2 3
  • Purinergic Receptor P2Y, G-Protein Coupled, 1 2 3 5
  • ATP Receptor 3 4
  • P2Y1 3 4
  • P2 Purinoceptor Subtype Y1 3
  • Platelet ADP Receptor 3
  • Purinergic Receptor 4

External Ids for P2RY1 Gene

Previous GeneCards Identifiers for P2RY1 Gene

  • GC03P149530
  • GC03P153397
  • GC03P153834
  • GC03P153873
  • GC03P154035
  • GC03P152552
  • GC03P149943

Summaries for P2RY1 Gene

Entrez Gene Summary for P2RY1 Gene

  • The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RY1 Gene

P2RY1 (Purinergic Receptor P2Y1) is a Protein Coding gene. Diseases associated with P2RY1 include clopidogrel resistance. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and receptor activity. An important paralog of this gene is P2RY2.

UniProtKB/Swiss-Prot for P2RY1 Gene

  • Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.

Tocris Summary for P2RY1 Gene

  • P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine nucleotides. To date, eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11-14) as well as the non-mammalian p2y3, p2y8 and p2y receptors.

Gene Wiki entry for P2RY1 Gene

PharmGKB "VIP" Summary for P2RY1 Gene

No data available for fRNAdb sequence ontologies and piRNA Summary for P2RY1 Gene

Genomics for P2RY1 Gene

Regulatory Elements for P2RY1 Gene

Genomic Location for P2RY1 Gene

Chromosome:
3
Start:
152,834,693 bp from pter
End:
152,841,439 bp from pter
Size:
6,747 bases
Orientation:
Plus strand

Genomic View for P2RY1 Gene

Genes around P2RY1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RY1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RY1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RY1 Gene

Proteins for P2RY1 Gene

  • Protein details for P2RY1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47900-P2RY1_HUMAN
    Recommended name:
    P2Y purinoceptor 1
    Protein Accession:
    P47900

    Protein attributes for P2RY1 Gene

    Size:
    373 amino acids
    Molecular mass:
    42072 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for P2RY1 Gene

neXtProt entry for P2RY1 Gene

Proteomics data for P2RY1 Gene at MOPED

Post-translational modifications for P2RY1 Gene

  • Glycosylation at Asn 11, Asn 27, Asn 113, and Asn 197
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RY1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for P2RY1 Gene

Domains & Families for P2RY1 Gene

Gene Families for P2RY1 Gene

Protein Domains for P2RY1 Gene

Suggested Antigen Peptide Sequences for P2RY1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47900

UniProtKB/Swiss-Prot:

P2RY1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with P2RY1: view

Function for P2RY1 Gene

Molecular function for P2RY1 Gene

GENATLAS Biochemistry:
purinoceptor,P2Y type 1,group 4,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly responding to 2 methylthio-ADP,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.
UniProtKB/Swiss-Prot Induction:
Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion mobilization and shape change in platelets.

Gene Ontology (GO) - Molecular Function for P2RY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031686 A1 adenosine receptor binding IEA --
GO:0045028 G-protein coupled purinergic nucleotide receptor activity IEA,ISS --
GO:0097110 scaffold protein binding IEA,ISS --
genes like me logo Genes that share ontologies with P2RY1: view
genes like me logo Genes that share phenotypes with P2RY1: view

Animal Models for P2RY1 Gene

MGI Knock Outs for P2RY1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RY1 Gene

Localization for P2RY1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RY1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RY1 Gene COMPARTMENTS Subcellular localization image for P2RY1 gene
Compartment Confidence
plasma membrane 5
cytosol 3
extracellular 2
mitochondrion 2
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for P2RY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
GO:0009986 cell surface IDA 23382103
GO:0016021 integral component of membrane IEA --
GO:0016323 basolateral plasma membrane IEA --
GO:0030425 dendrite IEA,ISS --
genes like me logo Genes that share ontologies with P2RY1: view

Pathways & Interactions for P2RY1 Gene

genes like me logo Genes that share pathways with P2RY1: view

Pathways by source for P2RY1 Gene

Gene Ontology (GO) - Biological Process for P2RY1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA,ISS --
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IEA --
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA,ISS --
GO:0007596 blood coagulation TAS --
GO:0010469 regulation of receptor activity IEA --
genes like me logo Genes that share ontologies with P2RY1: view

No data available for SIGNOR curated interactions for P2RY1 Gene

Drugs & Compounds for P2RY1 Gene

(46) Drugs for P2RY1 Gene - From: Novoseek, DGIdb, IUPHAR, PharmGKB, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Suramin Approved Pharma Antagonist, antagonist 18
Aspirin Approved Pharma Channel blocker 1029
MC-1 Investigational Pharma 0
ATP Pharma Agonist 0
MRS2179 Pharma Antagonist 0

(33) Additional Compounds for P2RY1 Gene - From: Novoseek, IUPHAR, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
2,2-pyridylisatogen tosylate
Antagonist
2,3-ddATP
Partial agonist, Agonist
2-ClATP
Antagonist
adenosine-3-5-bisphosphate
Antagonist
genes like me logo Genes that share compounds with P2RY1: view

Transcripts for P2RY1 Gene

mRNA/cDNA for P2RY1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(16) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for P2RY1 Gene

Purinergic receptor P2Y, G-protein coupled, 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RY1 Gene

No ASD Table

Relevant External Links for P2RY1 Gene

GeneLoc Exon Structure for
P2RY1
ECgene alternative splicing isoforms for
P2RY1

Expression for P2RY1 Gene

mRNA expression in normal human tissues for P2RY1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RY1 Gene

This gene is overexpressed in Esophagus - Mucosa (x6.1).

Protein differential expression in normal tissues from HIPED for P2RY1 Gene

This gene is overexpressed in Retina (38.5), Platelet (15.2), and Peripheral blood mononuclear cells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for P2RY1 Gene



SOURCE GeneReport for Unigene cluster for P2RY1 Gene Hs.654526

genes like me logo Genes that share expression patterns with P2RY1: view

Protein tissue co-expression partners for P2RY1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for P2RY1 Gene

Orthologs for P2RY1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RY1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RY1 35
  • 99.55 (n)
  • 99.73 (a)
P2RY1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia P2RY1 36
  • 97 (a)
OneToOne
P2RY1 35
  • 91.87 (n)
  • 96.78 (a)
dog
(Canis familiaris)
Mammalia P2RY1 35
  • 81.53 (n)
  • 87.84 (a)
P2RY1 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia P2ry1 16
P2ry1 36
  • 95 (a)
OneToOne
P2ry1 35
  • 87.13 (n)
  • 94.91 (a)
oppossum
(Monodelphis domestica)
Mammalia P2RY1 36
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia P2RY1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2ry1 35
  • 87.85 (n)
  • 95.17 (a)
chicken
(Gallus gallus)
Aves P2RY1 36
  • 86 (a)
OneToOne
P2RY1 35
  • 77.9 (n)
  • 86.19 (a)
lizard
(Anolis carolinensis)
Reptilia P2RY1 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia p2ry1-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia p2ry1 35
  • 75.25 (n)
  • 84.49 (a)
zebrafish
(Danio rerio)
Actinopterygii P2RY1 36
  • 72 (a)
OneToOne
LOC100003922 35
  • 72.04 (n)
  • 74.49 (a)
Species with no ortholog for P2RY1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RY1 Gene

ENSEMBL:
Gene Tree for P2RY1 (if available)
TreeFam:
Gene Tree for P2RY1 (if available)

Paralogs for P2RY1 Gene

genes like me logo Genes that share paralogs with P2RY1: view

Variants for P2RY1 Gene

Sequence variations from dbSNP and Humsavar for P2RY1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1439009 -- 152,834,036(+) AATGT(A/T)GTAAT upstream-variant-2KB
rs1439026 -- 152,833,524(+) ACACT(C/G)TTTAC upstream-variant-2KB
rs7624866 -- 152,834,723(+) AGAGG(A/C/T)TCCTG upstream-variant-2KB
rs9289876 -- 152,833,192(+) ACTTA(A/T)TGGTA upstream-variant-2KB
rs7643597 -- 152,837,539(+) AGTTA(C/T)TTCTG utr-variant-3-prime

Variation tolerance for P2RY1 Gene

Residual Variation Intolerance Score: 23.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.79% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RY1 Gene

HapMap Linkage Disequilibrium report
P2RY1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for P2RY1 Gene

Disorders for P2RY1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for P2RY1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
clopidogrel resistance
  • cyp2c19-related poor drug metabolism
- elite association - COSMIC cancer census association via MalaCards
Search P2RY1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for P2RY1

Genetic Association Database (GAD)
P2RY1
Human Genome Epidemiology (HuGE) Navigator
P2RY1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
P2RY1
genes like me logo Genes that share disorders with P2RY1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RY1 Gene

Publications for P2RY1 Gene

  1. Cloning and chromosomal localization of the human P2Y1 purinoceptor. (PMID: 8579591) Ayyanathan K. … Kunapuli S.P. (Biochem. Biophys. Res. Commun. 1996) 2 3 4 23 67
  2. The effect of P2Y-mediated platelet activation on the release of VEGF and endostatin from platelets. (PMID: 20063989) Bambace N.M. … Holmes C.E. (Platelets 2010) 3 23
  3. Genetics of platelet reactivity in normal, healthy individuals. (PMID: 19740098) Kunicki T.J. … Nugent D.J. (J. Thromb. Haemost. 2009) 3 23
  4. Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3. (PMID: 19637098) Storey R.F. … Armstrong M. (Platelets 2009) 3 23
  5. Hetero-oligomerization of the P2Y11 receptor with the P2Y1 receptor controls the internalization and ligand selectivity of the P2Y11 receptor. (PMID: 17824841) Ecke D. … Reiser G. (Biochem. J. 2008) 3 23

Products for P2RY1 Gene

Sources for P2RY1 Gene

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