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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

P2RY1 Gene

protein-coding GIFtS: 64
GCID: GC03P152552

purinergic receptor P2Y, G-protein coupled, 1

Explore 29 diseases affiliated with
P2RY1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Purinergic Receptor P2Y, G-Protein Coupled, 1¹ ²		P2Y Purinoceptor 1²
P2Y1¹ ² ³ ⁵		Platelet ADP Receptor²
ATP Receptor² ³		Purinergic Receptor³
P2 Purinoceptor Subtype Y1²

External Ids:	HGNC: 8539¹	Entrez Gene: 5028²	Ensembl: ENSG00000169860⁷	OMIM: 601167⁵	UniProtKB: P47900³

Export aliases for P2RY1 gene to outside databases

Previous GC identifers: GC03P149530 GC03P153397 GC03P153834 GC03P153873 GC03P154035 GC03P149943

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for P2RY1:

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor

subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine

nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to

mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably

to platelet aggregation. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: P2RY1_HUMAN, P47900

Function: Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to

mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably

to platelet aggregation

summary for P2RY1:

P2Y receptors are G-protein-coupled receptors that respond to extracellular purine and pyrimidine

nucleotides. To date eight mammalian P2Y receptors are known (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13

and P2Y14) as well as the non-mammalian chick p2y3, Xenopus p2y8 and turkey p2y receptors. p2y9 and p2y10

receptors are considered to be orphan receptors, and p2y5 is now known to actually be a leukotriene B4

receptor. P2Y receptor signaling is mediated through coupling to G proteins, mainly Gq/11, with P2Y12, P2Y13

and P2Y14 signaling through Gi/o. Activation of P2Y receptors initiates a wide range of signaling cascades

including PLCbeta, PLD, PLA2, AC and MAPK/MEK kinase. P2Y receptors are found in most human tissues. They

have diverse physiological roles including regulation of platelet aggregation, muscle contraction,

neurotransmission, and epithelial cell communication and migration.

Gene Wiki entry for P2RY1

PharmGKB "VIP" summary for P2RY1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_005612.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the P2RY1 gene promoter:
AML1a Nkx2-2 SREBP-1c SREBP-1b SREBP-1a FOXJ2 (long isoform) FOXJ2 RSRFC4
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: P2RY1 promoter sequence

Search SABiosciences Chromatin IP Primers for P2RY1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat P2RY1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.2 Ensembl cytogenetic band: 3q25.2 HGNC cytogenetic band: 3q25.2

P2RY1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P2RY1 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P152552: view genomic region (about GC identifiers)

Start:	152,552,736 bp from pter	End:	152,555,845 bp from pter
Size:	3,110 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: P2RY1_HUMAN, P47900 (See protein sequence)

Recommended Name: P2Y purinoceptor 1

Size: 373 amino acids; 42072 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

1 PDB 3D structure from and Proteopedia for P2RY1:

1Y36 (3D)

Explore the universe of human proteins at neXtProt for P2RY1: NX_P47900

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P47900

P2RY1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002554.1

ENSEMBL proteins:

ENSP00000304767

Reactome Protein details: P47900
Human Recombinant Protein Products for P2RY1:

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	Uscn Proteins for P2RY1

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	8630005
GO:0014069	postsynaptic density	ISS	--
GO:0016323	basolateral plasma membrane	IEA	--

P2RY1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for P2RY1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

P2RY1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR000142 P2Y_purnocptor

IPR002286 P2_purnocptor

IPR000276 GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P47900

ProtoNet protein and cluster: P47900

2 Blocks protein families:

IPB000142 P2Y purinoceptor signature

IPB002286 P2 purinoceptor signature

UniProtKB/Swiss-Prot: P2RY1_HUMAN, P47900

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: P2RY1_HUMAN, P47900

Function: Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to

mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably

to platelet aggregation

Induction: Repressed by the P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P. These inhibit calcium ion

mobilization and shape change in platelets

Genatlas biochemistry entry for P2RY1:

purinoceptor,P2Y type 1,group 4,metabotropic,expressed in bone,osteoblastic and brain cell lines,predominantly

responding to 2 methylthio-ADP,G protein coupled receptor superfamily

Gene Ontology (GO): 5/9 molecular function terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	TAS	8630005
GO:0005524	ATP binding	IEA	--
GO:0031686	A1 adenosine receptor binding	IEA	--
GO:0043531	ADP binding	IEA	--
GO:0045028	G-protein coupled purinergic nucleotide receptor activity	ISS	--

P2RY1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for P2RY1:

Decreased melanin production

2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for P2ry1):

hematopoietic system

homeostasis/metabolism

P2RY1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for P2RY1: P2ry1^tm1Lex P2ry1^tm1Bhk P2ry1^tm1Gac

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for P2RY1

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		hsa-miR-576-3p
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/9 super-pathways (see all 9) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			GPCRs, Class A Rhodopsin-like	0.41
	GPCR ligand binding	0.75			Neuroactive ligand-receptor interaction	0.38

Nucleotide-like (purinergic) receptors

	Nucleotide-like (purinergic) receptors	1.00			Nucleotide GPCRs	0.56
	P2Y receptors	0.75

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Signal transduction_IP3 signaling

Signal transduction_IP3 signaling

1.00

Signal transduction IP3 signaling

0.92

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for P2RY1

Signal transduction IP3 signaling

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for P2RY1

P2Y Receptor Signaling

1 GeneGo (Thomson Reuters) Pathway for P2RY1

Signal transduction IP3 signaling

2 BioSystems Pathways for P2RY1

	GPCRs, Class A Rhodopsin-like
	Nucleotide GPCRs

5/13 Reactome Pathways for P2RY1 (see all 13)

	GPCR downstream signaling
	Hemostasis
	P2Y receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR

1 PharmGKB Pathway for P2RY1

Platelet Aggregation Inhibitor Pathway, Pharmacodynamics

1 Kegg Pathway (Kegg details for P2RY1):

Neuroactive ligand-receptor interaction

P2RY1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for P2RY1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/127 Interacting proteins for P2RY1 (P47900^{2, 3} ENSP00000304767⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 127)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SLC9A3R1	O14745²^,³, ENSP00000262613⁴	MINT-1796624 MINT-1796574 I2D: score=4 STRING: ENSP00000262613
ADORA1	P30542³, ENSP00000308549⁴	I2D: score=3 STRING: ENSP00000308549
SLC9A3R2	Q15599³, ENSP00000408005⁴	I2D: score=1 STRING: ENSP00000408005
ADRBK1	ENSP00000312262⁴	STRING: ENSP00000312262
AGTR1	ENSP00000273430⁴	STRING: ENSP00000273430

About this table

Gene Ontology (GO): 5/28 biological process terms (GO ID links to tree view) (see all 28): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001934	positive regulation of protein phosphorylation	ISS	--
GO:0007166	cell surface receptor signaling pathway	TAS	8630005
GO:0007186	G-protein coupled receptor signaling pathway	ISS	--
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	IEA	--
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway	TAS	8630005

P2RY1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

P2RY1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for P2RY1 available from Tocris Bioscience About this table

Compound	Action	CAS #
MRS 2365	Highly potent and selective P2Y1 agonist	[436847-09-5]
MRS 2279	Selective, high affinity P2Y1 antagonist	[367909-40-8]
2-Methylthioadenosine diphosphate trisodium salt	Potent agonist for P2Y1, P2Y12 and P2Y13	[34983-48-7]
MRS 2500 tetraammonium salt	Extremely potent and selective P2Y1 antagonist	[779323-43-2]
MRS 2179 tetrasodium salt	Selective P2Y1 antagonist	[101204-49-3]

1 HMDB Compound for P2RY1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--

10/40 Novoseek chemical compound relationships for P2RY1 gene (see all 40) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
mrs2179	94.4	10	14644082 (1), 15265806 (1), 12807993 (1), 17459368 (1) (see all 10)
2-mesadp	91.8	4	11502873 (2), 16795051 (1), 11877327 (1)
adp	87.7	134	14644082 (3), 15514209 (3), 18174464 (3), 12189014 (3) (see all 77)
3'-phosphoadenosine 5'-phosphate	87.7	8	9858246 (1), 15203713 (1), 11422381 (1), 12871420 (1) (see all 6)
cangrelor	87.3	6	15668190 (1), 17459368 (1), 18480058 (1), 18574670 (1) (see all 6)
a3p5ps	87	3	12189014 (2), 11502873 (1)
2',5'-adp	84.6	6	9858246 (1), 15668190 (1), 11054084 (1), 11172816 (1) (see all 5)
udpbetas	82.5	1	10869373 (1)
bzatp	81.8	2	18048695 (1), 16373435 (1)
ppads	77.4	4	9134216 (2), 11159687 (1), 12694404 (1)

Search CenterWatch for drugs/clinical trials and news about P2RY1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for P2RY1 gene:

NM_002563.3

Unigene Cluster for P2RY1:

Purinergic receptor P2Y, G-protein coupled, 1

Hs.654526 [show with all ESTs]

Unigene Representative Sequence: NM_002563

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000305097(uc003ezq.3)

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Additional cDNA sequence:

AF018284.1 AK313920.1 AY136752.1 BC074784.2 BC074785.2 U42029.1 U42030.1 Z49205.1

1 DOTS entry:

DT.309061

16 AceView cDNA sequences:

NM_002563 BC074785 BC074784 AU100240 AU107922 AF018284 U42029 U42030

BX281527 AY136752 BX497359 AI820551 CF147800 Z49205 AW753128 T65835

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

P2RY1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

P2RY1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Adult Endothelial Cells

Blood Brain Barrier, Endothelium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Primitive gut tube-like cells (A scalable, suspensi...)

See P2RY1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for P2RY1

SOURCE GeneReport for Unigene cluster: Hs.654526

SABiosciences Expression via Pathway-Focused PCR Array including P2RY1:

G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RY1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for P2RY1 gene from 4/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	P2RY1¹	purinergic receptor P2Y, G-protein coupled, 1	77.9(n) 86.19(a)		396275 NM_205333.1 NP_990664.1
lizard (Anolis carolinensis)	Reptilia	P2RY1⁶	--	86(a)	1 ↔ 1	3(17226907-17227959)
African clawed frog (Xenopus laevis)	Amphibia	p2ry1-A²	P2Y1 nucleotide receptor	78.8(n)		AF432354.1
zebrafish (Danio rerio)	Actinopterygii	LOC100003922¹	p2Y purinoceptor 1-like	71.65(n) 74.49(a)		100003922 XM_001343319.3 XP_001343355.1

ENSEMBL Gene Tree for P2RY1 (if available)
TreeFam Gene Tree for P2RY1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for P2RY1 gene

OXGR1² P2RY4² GPR17² P2RY11² P2RY6² GPR174² LPAR6² LPAR5²

CYSLTR1² GPR183² LPAR4² CYSLTR2² P2RY10² SUCNR1² P2RY2² PTAFR²

18/31 SIMAP similar genes for P2RY1 using alignment to 1 protein entry: P2RY1_HUMAN(see all similar genes):

OXGR1 GPR17 P2RY4 CYSLTR2 KPG_011 CYSLTR1

P2RY2 LPAR6 P2RY5 CXCR6 LPAR4 SUCNR1

CCR1 GPR183 GPR4 P2RY8 F2RL1 F2RL2

P2RY1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Pop	Total sample
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77598898^1,2	F	--	149941391(+)	`ACAGCG/ACCCAG`	1	--	us2k¹		2	NA EA	240
rs56959008^1,2	C	--	149941426(+)	`TTTTTT/AAAAAA`	1	--	us2k¹		2	WA	120
rs9289876^1,2	C,F,H	--	149941500(+)	`ACTTAA/TTGGTA`	1	--	us2k¹		5	NS EA NA	540
rs59389242^1,2		--	149941530(+)	`TCAAAA/GCACTC`	1	--	us2k¹		1	WA	118
rs16864605^1,2	C,F,H	--	149941590(+)	`TTGCCT/CAGGTT`	1	--	us2k¹		11	NA NS EA WA	914
rs1439026^1,2	C,F,A,H	--	149941832(+)	`ACACTG/CTTTAC`	1	--	us2k¹		10	NS EA WA NA CSA	667
rs75362116^1,2	F	--	149941945(+)	`CTATAT/CGTGTT`	1	--	us2k¹		1	WA	118
rs113428864^1,2		--	149941962(+)	`AAGAAC/TCATCT`	1	--	us2k¹		2	CSA WA	120
rs112649148^1,2		--	149942262(+)	`TCCAAT/CTAAAC`	1	--	us2k¹		2	CSA WA	120
rs1439009^1,2	C,F,A,H	--	149942344(+)	`AATGTA/TGTAAT`	1	--	us2k¹		13	NS EA NA WA CSA	937

HapMap Linkage Disequilibrium report for P2RY1 (152552736 - 152555845 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for P2RY1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing P2RY1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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P2RY1 for disorders           About GeneDecksing

OMIM gene information: 601167    OMIM disorders: --

20/29 diseases for P2RY1 (see all 29):    About MalaCards

venous insufficiency extrapulmonary tuberculosis erythrocytosis hirschsprung's disease

cystic fibrosis thrombosis embryonal carcinoma vascular disease

osteosarcoma astrocytoma skin cancer fibrosis

pertussis alzheimer's disease periodontitis thyroid cancer

tuberculosis thyroiditis prostate cancer ischemia

6 Novoseek disease relationships for P2RY1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
astrocytoma	52.4	9	15913566 (1), 11985476 (1), 9134216 (1), 15602005 (1) (see all 6)
thrombosis	40.7	4	12933533 (1), 15203715 (1), 16234484 (1), 10960076 (1)
glioma	16.4	7	11159687 (3), 14718252 (2), 11904146 (2)
tumors	0.833	2	12880424 (1), 20063989 (1)
cardiovascular diseases	0	1	14645014 (1)
osteosarcoma	0	1	10318853 (1)

Genetic Association Database (GAD): P2RY1
Human Genome Epidemiology (HuGE) Navigator: P2RY1 (12 documents)

Export disorders for P2RY1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for P2RY1 gene, integrated from 9 sources (see all 268):
(articles sorted by number of sources associating them with P2RY1)

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world of online information

Cloning and chromosomal localization of the human P2Y1 purinoceptor. (PubMed id 8579591)^{1, 2, 3, 9} Ayyanathan K....Kunapuli S.P. (1996)
Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP. (PubMed id 15514209)^{1, 4, 9} Hetherington S.L....Samani N.J. (2005)
Cloning and sequencing of a human cDNA encoding endothelial P2Y1 purinoceptor. (PubMed id 8666290)^{1, 2, 9} Leon C.... Gachet C. (1996)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Molecular basis for ADP-induced platelet activation. II. The P2Y1 receptor mediates ADP-induced intracellular calcium mobilization and shape change in platelets. (PubMed id 9442040)^{1, 2} Jin J.... Kunapuli S.P. (1998)
Cloning and tissue distribution of the human P2Y1 receptor. (PubMed id 8630005)^{1, 2} Janssens R....Boeynaems J.-M. (1996)
Reciprocal cross-talk between P2Y1 and P2Y12 receptors at the level of calcium signaling in human platelets. (PubMed id 15187029)^{1, 9} Hardy A.R....Poole A.W. (2004)
Distinct roles for protein kinase C isoforms in regulating platelet purinergic receptor function. (PubMed id 16804093)^{1, 9} Mundell S.J....Poole A.W. (2006)
Immunolocalization of P2Y1 and TPalpha receptors in platelets showed a major pool associated with the membranes of alpha -granules and the open canalicular system. (PubMed id 12393588)^{1, 9} Nurden P....Nurden A.T. (2003)
ADP stimulates human endothelial cell migration via P2Y1 nucleotide receptor-mediated mitogen-activated protein kinase pathways. (PubMed id 18174464)^{1, 9} Shen J. and DiCorleto P.E. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5028	HGNC: 8539	AceView: P2RY1	Ensembl:ENSG00000169860	euGenes: HUgn5028
ECgene: P2RY1	Kegg: 5028	H-InvDB: P2RY1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for P2RY1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for P2RY1 gene
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P2RY1 Gene

purinergic receptor P2Y, G-protein coupled, 1

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purinergic receptor P2Y, G-protein coupled, 1

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