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P2RX7 Gene

protein-coding GIFtS: 65

GC12P120033

purinergic receptor P2X, ligand-gated ion channel, 7
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC20089 ^¹, ²
P2X7 ^¹, ², ³, ⁵

Descriptions
ATP receptor ^², ³
P2X purinoceptor 7 ^²
P2X7 receptor ^²
P2Z receptor ^², ³
Purinergic receptor ^³
purinergic receptor P2X, ligand-gated ion channel, 7 ^²
purinergic receptor P2X7 ^²

External Ids
HGNC: 8537¹
Entrez Gene: 5027²
UniProtKB: Q99572³
Ensembl: ENSG00000089041⁷

Search outside databases for aliases for P2RX7 gene

Previous GC identifers: GC12P120432 GC12P121185 GC12P121353 GC12P119982

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for P2RX7:

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as

a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the

formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by

ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in

gene expression. Multiple alternatively spliced variants which would encode different isoforms

have been identified although some fit nonsense-mediated decay (NMD) criteria. [provided by

RefSeq]

UniProtKB/Swiss-Prot: P2RX7_HUMAN, Q99572

Function: Receptor for ATP that acts as a ligand gated ion channel. Responsible for ATP-dependent

lysis of macrophages through the formation of membrane pores permeable to large molecules. Could

function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells

Gene Wiki entry for P2RX7

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the P2RX7 gene

Entrez Gene cytogenetic band: 12q24 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24

P2RX7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P120033: (about GC identifiers)

Start:	120,055,061 bp from pter
End:	120,108,259 bp from pter
Size:	53,199 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009775.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: P2RX7_HUMAN, Q99572 (See protein sequence)

Recommended Name: P2X purinoceptor 7

Size: 595 amino acids; 68559 Da

Subunit: Forms homo- or heteropolymers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3,

HSPA1, HSPCB, HSPA8, PIK230 and PTPRB

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: O14991 Q96EV7

Post-translational modifications:

Phosphorylation results in its inactivation¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002553.2

ENSEMBL proteins:

ENSP00000261826 ENSP00000366367 ENSP00000330696

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (P2RX7)
	Human Recombinant Proteins from Abnova (P2RX7)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	ISS	--
GO:0005886	plasma membrane	ISS	17785580
GO:0005887	integral to plasma membrane	IC	9038151
GO:0032059	bleb	ISS	--

About this table

Antibodies for P2RX7:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of P2RX7
	Sigma-Aldrich Antibodies for P2RX7
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (P2RX7), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (P2RX7)
	Search Novus for antibodies for P2RX7

Assays for P2RX7:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q99572

ProtoNet protein and cluster: Q99572

2 Blocks protein families:

IPB001429 ATP P2X receptor

IPB003050 P2X7 purinoceptor signature

UniProtKB/Swiss-Prot: P2RX7_HUMAN, Q99572

Similarity: Belongs to the P2X receptor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RX7)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RX7)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002562

Applied Biosystems Silencer® siRNAs for P2RX7

Sigma-Aldrich siRNA and siRNA Panels for P2RX7

Sigma-Aldrich shRNA Panels and shRNA for P2RX7

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for P2RX7
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002562
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002562
untagged cDNA clones in CMV expression vector (see all 2): AB209709

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002562

UniProtKB/Swiss-Prot: P2RX7_HUMAN, Q99572

Function: Receptor for ATP that acts as a ligand gated ion channel. Responsible for ATP-dependent

lysis of macrophages through the formation of membrane pores permeable to large molecules. Could

function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells

Genatlas biochemistry entry for P2RX7:

purinoceptor,P2X7

8 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for P2rx7):

behavior/neurological	cellular	growth/size	hematopoietic system	immune system
limbs/digits/tail	skeleton	touch/vibrissae

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001530	lipopolysaccharide binding	ISS	--
GO:0001614	purinergic nucleotide receptor activity	IPI	9038151
GO:0004872	receptor activity	IEA	--
GO:0004931	ATP-gated cation channel activity	IDA	9038151
GO:0005102	receptor binding	ISS	17785580

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for P2RX7

5/40 Interacting proteins for P2RX7 (ENSP00000261826³ Q99572¹) via UniProtKB, MINT, and/or STRING (see all 40 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ABL1	P00519¹	EBI-1753251, EBI-375543
GRB2	P62993¹	EBI-1753251, EBI-401755
NCK1	P16333¹	EBI-1753251, EBI-389883
ATP5E	ENSP00000243997³	STRING (score=.948)
P2RY2	ENSP00000310305³	STRING (score=.878)

About this table

5/17 Gene Ontology (GO) biological process terms (links to tree view) (see all 17 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002028	regulation of sodium ion transport	ISS	17785580
GO:0006811	ion transport	IEA	--
GO:0007166	cell surface receptor linked signal transduction	ISS	--
GO:0010524	positive regulation of calcium ion transport into cytosol	IDA	9038151
GO:0019233	sensory perception of pain	ISS	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for P2RX7:

Antagonist

Compounds for P2RX7 available from Tocris Bioscience

Compound	Action	CAS number
AZ 11645373	Potent and selective human P2X7 antagonist	[227088-94-0]
AZ 10606120 dihydrochloride	Potent P2X7 receptor antagonist
NF 449	Highly selective P2X1 antagonist	[389142-38-5]
GW 791343 hydrochloride	P2X7 allosteric modulator	[1019779-04-4]
A 438079 hydrochloride	Competitve P2X7 antagonist	[899507-36-9]

About this table

10/22 Novoseek chemical compound relationships for P2RX7 gene (see all 22 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	84.41	242	15304508 (4), 12151017 (4), 9384508 (4), 15070812 (4) (see all 99)
oatp	83.79	14	19385050 (3), 16341234 (2), 14522840 (1), 18627610 (1) (see all 7)
2-methylthio-atp	74.48	2	9384508 (1)
atpgammas	69.84	2	12956724 (1), 9384508 (1)
tnp-atp	68.15	7	17785580 (1)
propidium	65.27	2	10457053 (1), 9038151 (1)
atpo	60.88	2	1431111 (2)
decavanadate	56.77	5	16487507 (4)
calcium	55.34	51	12660148 (5), 9579723 (3), 16805847 (2), 15469955 (2) (see all 34)
adp	53.27	6	16117789 (2), 9753640 (1), 16341234 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RX7)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RX7)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_002562

Sigma-Aldrich siRNA and siRNA Panels for P2RX7

Sigma-Aldrich shRNA Panels and shRNA for P2RX7

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002562

REFSEQ mRNAs for P2RX7 gene:

NM_002562.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002562

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002562
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002562
                                 untagged cDNA clones in CMV expression vector (see all 2): AB209709

Additional cDNA sequence:

AB209709.1 AF086177.1 AK090866.1 AK225163.1 AK290405.1 AK294126.1 AK296432.1 AY847298.1

AY847299.1 AY847300.1 AY847301.1 AY847302.1 AY847303.1 AY847304.1 BC007679.2 BC011913.2

BC121157.1 BC121158.1 DQ399293.1 Y09561.1

13 DOTS entries:

DT.40195733 DT.91889751 DT.121148625 DT.100016588 DT.121148623 DT.91816221 DT.121148608 DT.121148617

DT.121148629 DT.95095086 DT.100777516 DT.121148599 DT.121148612

24/72 AceView cDNA sequences (see all 72 ):

NM_177427 BM557229 BE503402 AI917481 BE858390 AA362345 AI468408 AA362346

AI419360 NM_002562 AI886085 AI655467 AI347736 N24715 BC007679 BE816017

BF347747 BG912072 AI869236 BF690388 T58469 AX746656 AK090866 AV728688

highest scoring ESTs for P2RX7:

AI962024 AK090866 BC007679 BC011913 BF690388 BG912072 BI861622 BM557229 CD104987 Y09561

Unigene Cluster for P2RX7:

Purinergic receptor P2X, ligand-gated ion channel, 7

Hs.507102 [show with all ESTs]

Unigene Representative Sequence: NM_002562

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for P2RX7 (see all 13 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	·	1f	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9a	·	9b	^	10	^	11	^	12	^	13	^	14	^	15a	·	15b
SP1:																							-		-
SP2:																	-						-		-
SP3:																							-		-
SP4:																	-						-		-
SP5:																	-						-		-		-		-

About this scheme

ECgene alternative splicing isoforms for P2RX7

3 Ensembl transcripts including schematic representations:

ENST00000261826 ENST00000377162 ENST00000328963

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

P2RX7 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for P2RX7

¹ / ² / ³

3 probe-sets matching P2RX7 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33697_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	Y12851	0.20	1.00	0.72	1
207091_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002562	0.60	1.00	0.82	1
207091_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.507102
Expression variation in blood from EXPOLDB for P2RX7

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for P2RX7 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	P2RX7¹	--	purinergic receptor P2X, ligand-gated ion channel, more	88.1(n) 85.69(a)	448778 XM_534669.2 XP_534669.2
chimpanzee (Pan troglodytes)	P2RX7¹	--	purinergic receptor P2X, ligand-gated ion channel, more	99.66(n) 99.66(a)	452318 XM_509436.2 XP_509436.2
cow (Bos taurus)	P2RX7¹	--	purinergic receptor P2X, ligand-gated ion channel, more	85.6(n) 82.52(a)	286814 XM_591410.2 XP_591410.2
rat (Rattus norvegicus)	P2rx7¹	--	purinergic receptor P2X, ligand-gated ion channel, more	81.85(n) 80.17(a)	29665 NM_019256.1 NP_062129.1
mouse (Mus musculus)	P2rx7^{1, 5}	5⁵	purinergic receptor P2X, ligand-gated ion channel, more^{1, 5}	81.85(n)¹ 80.67(a)¹	18439¹ NM_011027.2¹ NP_035157.2¹ AI428678⁵ AI467586⁵ (see all 20)

About this table Species with no ortholog for P2RX7

ENSEMBL Gene Tree for P2RX7

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for P2RX7 gene

P2RX5² P2RX1² P2RX4² P2RX6²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/536 NCBI SNPs in P2RX7 are shown (see all 536 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 170)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs684201^1,2	A,C,F,H	120054726(+)	`AGGCAG/ATGGAA`	1	--	ng5¹		14	NA EA EU WA NS	2643
	rs3751143^1,2	A,C,F,H	120106687(-)	`ACAGCT/GCCTCC`	1	A/E	mis¹		12	NS EU EA WA MN CSAM NA PA	2979
	rs494986^1,2	A,C,F,H	120054319(-)	`atttaG/Ttatag`	1	--	ng5¹		2	WA NS	531
	rs1718119^1,2	A,C,F,H	120099486(-)	`CACAGC/TGGCCT`	1	A/T	mis¹ ese³		16	MN EU EA WA NA NS PA	2049
	rs208294^1,2	A,C,F,H	120084636(-)	`TTCATG/ACACTA`	1	H/Y	mis¹		15	EA MN NS EU WA NA PA	2401
	rs2230912^1,2	C,F,H,O	120106579(+)	`GATACA/GGCTGC`	1	Q/R	mis¹ ese³		14	MN EU EA WA NA NS PA	2387
--	rs17525809^1,2	C,F,H	120077072(+)	`GATCGT/CGGAGA`	1	A/V	mis¹ ese³		15	NA EA NS EU WA PA	1633
	rs11065445^1,2	C,F,H	120053328(+)	`CATATC/GTACTA`	1	--	ng5¹		2	EU WA	224
	rs7958316^1,2	C,F,H	120089756(+)	`TTTCCA/GTCGCC`	1	R/H	mis¹ ese³		11	NS EU EA WA NA PA	1421
--	rs16950860^1,2	C,F,H	120089737(+)	`ACTGCC/TGTCCC`	1	R/C	mis¹ ese³		12	NA EU EA WA	1028

About this table

HapMap Linkage Disequilibrium images for P2RX7 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 602566

10/22 Novoseek disease relationships for P2RX7 gene (see all 22 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia lymphocytic chronic	43.90	2	18937793 (1), 15184265 (1)
leukaemia lymphocytic	42.18	5	12931211 (2), 15180873 (1), 12727428 (1), 12493261 (1)
lymphocytic leukemia chronic b-cell	37.34	3	15089763 (1), 18937793 (1), 11781259 (1)
mycobacterial infection	31.58	1	15942904 (1)
renal cyst	17.99	1	15325248 (1)
inflammation	16.54	6	18772321 (1), 17367517 (1), 18602931 (1), 11549724 (1) (see all 6)
bipolar disorder	15.28	7	17558618 (1), 16822851 (1), 18543274 (1)
tuberculosis	14.16	19	19076224 (4), 12404161 (1), 11693438 (1)
sarcoidosis	11.33	3	15508727 (1), 12670722 (1), 11678912 (1)
necrosis	10.61	5	17558618 (1), 17525149 (1), 16613995 (1), 15830104 (1) (see all 5)

About this table

Human Gene Mutation Database: P2RX7
Genetic Association Database: P2RX7
Human Genome Epidemiology Navigator: P2RX7 (30 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/298 PubMed articles for P2RX7 gene (see all 298 ):

The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. (PubMed id 9038151)^{1, 2, 3, 4} Rassendren F....Surprenant A. (1997)
Gene structure and chromosomal localization of the human P2X7 receptor. (PubMed id 9826911)^{2, 3, 4} Buell G.N....Antonarakis S.E. (1998)
A 5' intronic splice site polymorphism leads to a null allele of the P2X7 gene in 1-2% of the Caucasian population. (PubMed id 15862308)^{1, 3, 6} Skarratt K.K....Wiley J.S. (2005)
P2X7 polymorphism and chronic lymphocytic leukaemia: lack of correlation with incidence, survival and abnormalities of chromosome 12. (PubMed id 12931211)^{1, 3, 6} Zhang L.Y....Cross N.C. (2003)
Polymorphism in the P2X7 receptor gene and survival in chronic lymphocytic leukaemia. (PubMed id 12493261)^{1, 3, 6} Thunberg U....Rosenquist R. (2002)
Proteomic and functional evidence for a P2X7 receptor signalling complex. (PubMed id 11707406)^{1, 3, 4} Kim M.... Surprenant A. (2001)
1513A/C polymorphism in the P2X7 receptor gene in chronic lymphocytic leukemia: absence of correlation with clinical outcome. (PubMed id 15089763)^{1, 3, 6} Nuckel H....Siffert W. (2004)
The P2X7 receptor gene A1513C polymorphism does not contribute to risk of familial or sporadic chronic lymphocytic leukemia. (PubMed id 15184265)^{1, 3, 6} Sellick G.S....Houlston R.S. (2004)
Association of a polymorphism in the P2X7 gene with tuberculosis in a Gambian population. (PubMed id 12404161)^{1, 3, 6} Li C.M....Lammas D.A. (2002)
The P2X7 receptor gene polymorphism 1513 A-->C has no effect on clinical prognostic markers and survival in multiple myeloma. (PubMed id 16321858)^{3, 6} Paneesha S....Pratt G. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5027	HGNC: 8537	AceView: P2RX7	Ensembl:ENSG00000089041	euGenes: HUgn5027
ECgene: P2RX7	H-InvDB: P2RX7

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for P2RX7	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for P2RX7
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for P2RX7:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for P2RX7-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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P2RX7 Gene at Home site.
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P2RX7 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for P2RX7

Summaries
for P2RX7

Genomic Location
for P2RX7

Proteins
for P2RX7

Protein Domains/
Families
for P2RX7

Gene Function
for P2RX7

Pathways & Interactions
for P2RX7

Drugs & Compounds
for P2RX7

Transcripts
for P2RX7

Expression
for P2RX7

Orthologs
for P2RX7

Paralogs
for P2RX7

SNPs/Variants
for P2RX7

Disorders & Mutations
for P2RX7

Medical News
for P2RX7

Publications
for P2RX7

Search for P2RX7

Genome Databases showing P2RX7

Other Databases showing P2RX7

Specialized Databases showing P2RX7

Licensable Technologies
for P2RX7

Services
for P2RX7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

P2RX7 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor P2RX7

Summariesfor P2RX7

Genomic Locationfor P2RX7

Proteinsfor P2RX7

Protein Domains/Familiesfor P2RX7

Gene Functionfor P2RX7

Pathways & Interactionsfor P2RX7

Drugs & Compoundsfor P2RX7

Transcriptsfor P2RX7

Expression for P2RX7

Orthologsfor P2RX7

Paralogsfor P2RX7

SNPs/Variantsfor P2RX7

Disorders & Mutationsfor P2RX7

Medical Newsfor P2RX7

Publicationsfor P2RX7

Search for P2RX7

Genome Databases showing P2RX7

Other Databases showing P2RX7

Specialized Databases showing P2RX7

Licensable Technologiesfor P2RX7

Servicesfor P2RX7

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for P2RX7

Summaries
for P2RX7

Genomic Location
for P2RX7

Proteins
for P2RX7

Protein Domains/
Families
for P2RX7

Gene Function
for P2RX7

Pathways & Interactions
for P2RX7

Drugs & Compounds
for P2RX7

Transcripts
for P2RX7

Expression
for P2RX7

Orthologs
for P2RX7

Paralogs
for P2RX7

SNPs/Variants
for P2RX7

Disorders & Mutations
for P2RX7

Medical News
for P2RX7

Publications
for P2RX7

Licensable Technologies
for P2RX7

Services
for P2RX7