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Aliases for P2RX7 Gene

Aliases for P2RX7 Gene

  • Purinergic Receptor P2X 7 2 3 5
  • ATP Receptor 3 4
  • P2Z Receptor 3 4
  • P2X7 3 4
  • Purinergic Receptor P2X, Ligand-Gated Ion Channel, 7 2
  • Purinergic Receptor P2X, Ligand Gated Ion Channel, 7 3
  • Purinergic Receptor P2X7 Variant A 3
  • Purinergic Receptor 4
  • P2X Purinoceptor 7 3
  • P2X7 Receptor 3

External Ids for P2RX7 Gene

Previous GeneCards Identifiers for P2RX7 Gene

  • GC12P120432
  • GC12P121185
  • GC12P121353
  • GC12P119982
  • GC12P120033
  • GC12P121570
  • GC12P118580
  • GC12P121186
  • GC12P121278
  • GC12P121334
  • GC12P121398

Summaries for P2RX7 Gene

Entrez Gene Summary for P2RX7 Gene

  • The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]

GeneCards Summary for P2RX7 Gene

P2RX7 (Purinergic Receptor P2X 7) is a Protein Coding gene. Diseases associated with P2RX7 include Extrapulmonary Tuberculosis and Chronic Lymphocytic Leukemia. Among its related pathways are Immune System and Platelet homeostasis. GO annotations related to this gene include protein homodimerization activity and receptor activity. An important paralog of this gene is P2RX4.

UniProtKB/Swiss-Prot for P2RX7 Gene

  • Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.

Tocris Summary for P2RX7 Gene

  • P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains.

Gene Wiki entry for P2RX7 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RX7 Gene

Genomics for P2RX7 Gene

Regulatory Elements for P2RX7 Gene

Enhancers for P2RX7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F121196 1.4 FANTOM5 Ensembl ENCODE 19.3 +64.4 64352 1.5 BCOR ATF1 JUN ZMYM3 MAX ZNF175 ZNF121 IKZF1 EED ZBTB33 P2RX4 P2RX7 CAMKK2 ACADS ENSG00000256569 OASL ENSG00000274029
GH12F121143 1.7 FANTOM5 Ensembl ENCODE 13.8 +11.8 11809 3.1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A ZNF263 SP3 JUNB REST TBX21 P2RX4 P2RX7 HNF1A-AS1 CAMKK2 OASL ENSG00000257053
GH12F121059 1.4 FANTOM5 Ensembl ENCODE 12.9 -72.4 -72412 1.8 HDGF PKNOX1 ZBTB40 RAD21 YY1 THAP11 SMARCA5 KLF11 ZNF654 REST OASL P2RX4 P2RX7 C12orf43 SPPL3 ACADS ENSG00000256569 CAMKK2 LOC105378258
GH12F121189 1.3 Ensembl ENCODE 12.5 +58.0 58007 3.6 HDGF PKNOX1 ARID4B SIN3A GLIS2 FOS ZNF263 SP3 SP5 TBX21 P2RX7 ANAPC5 RNF34 P2RX4 ENSG00000274029 GC12M121199
GH12F121110 1.1 Ensembl ENCODE 13.3 -22.4 -22436 0.4 ELF3 TBL1XR1 WRNIP1 KLF17 ARID4B ZNF2 RAD21 ZNF143 MIXL1 THAP11 P2RX7 P2RX4 PIRC57
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around P2RX7 on UCSC Golden Path with GeneCards custom track

Promoters for P2RX7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000438256 381 1201 PKNOX1 ATF1 WRNIP1 ZNF48 RAD21 YY1 SLC30A9 GLIS2 EGR2 ZFP69B

Genomic Location for P2RX7 Gene

121,132,819 bp from pter
121,188,032 bp from pter
55,214 bases
Plus strand

Genomic View for P2RX7 Gene

Genes around P2RX7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RX7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RX7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RX7 Gene

Proteins for P2RX7 Gene

  • Protein details for P2RX7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    P2X purinoceptor 7
    Protein Accession:
    Secondary Accessions:
    • A8K2Z0
    • E7EMK6
    • F5H6P2
    • F5H7E8
    • F8W951
    • O14991
    • Q4VKH8
    • Q4VKH9
    • Q4VKI0
    • Q4VKI1
    • Q4VKI2
    • Q4VKI3
    • Q4VKI4
    • Q7Z771
    • Q96EV7

    Protein attributes for P2RX7 Gene

    595 amino acids
    Molecular mass:
    68585 Da
    Quaternary structure:
    • Functional P2XRs are organized as homomeric and heteromeric trimers. Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB. Interacts (via C-terminus) with EMP2 (PubMed:12107182).

    Alternative splice isoforms for P2RX7 Gene

neXtProt entry for P2RX7 Gene

Post-translational modifications for P2RX7 Gene

  • ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel.
  • Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface.
  • Phosphorylation results in its inactivation.
  • Glycosylation at Asn 187, Asn 202, Asn 213, Asn 241, and Asn 284
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for P2RX7 (P2X7)
  • Abcam antibodies for P2RX7
  • Cloud-Clone Corp. Antibodies for P2RX7
  • Santa Cruz Biotechnology (SCBT) Antibodies for P2RX7

No data available for DME Specific Peptides for P2RX7 Gene

Domains & Families for P2RX7 Gene

Gene Families for P2RX7 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the P2X receptor family.
  • Belongs to the P2X receptor family.
genes like me logo Genes that share domains with P2RX7: view

Function for P2RX7 Gene

Molecular function for P2RX7 Gene

GENATLAS Biochemistry:
UniProtKB/Swiss-Prot Function:
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.

Gene Ontology (GO) - Molecular Function for P2RX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001530 lipopolysaccharide binding ISS --
GO:0001614 purinergic nucleotide receptor activity IDA 9038151
GO:0004872 receptor activity IEA --
GO:0004931 extracellular ATP-gated cation channel activity TAS --
GO:0005102 receptor binding ISS 17785580
genes like me logo Genes that share ontologies with P2RX7: view
genes like me logo Genes that share phenotypes with P2RX7: view

Animal Models for P2RX7 Gene

MGI Knock Outs for P2RX7:

Animal Model Products

  • Taconic Biosciences Mouse Models for P2RX7

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RX7 Gene

Localization for P2RX7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RX7 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RX7 gene
Compartment Confidence
plasma membrane 5
nucleus 4
extracellular 3
cytosol 3
cytoskeleton 2
mitochondrion 2
lysosome 1

Gene Ontology (GO) - Cellular Components for P2RX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005639 integral component of nuclear inner membrane IBA --
GO:0005737 cytoplasm ISS --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IC 9038151
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with P2RX7: view

Pathways & Interactions for P2RX7 Gene

genes like me logo Genes that share pathways with P2RX7: view

Pathways by source for P2RX7 Gene

Interacting Proteins for P2RX7 Gene

Selected Interacting proteins: Q99572-P2RX7_HUMAN for P2RX7 Gene via IID

Gene Ontology (GO) - Biological Process for P2RX7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0000902 cell morphogenesis IEA --
GO:0001845 phagolysosome assembly IEA --
GO:0001916 positive regulation of T cell mediated cytotoxicity IEA --
GO:0001934 positive regulation of protein phosphorylation IEA --
genes like me logo Genes that share ontologies with P2RX7: view

No data available for SIGNOR curated interactions for P2RX7 Gene

Drugs & Compounds for P2RX7 Gene

(64) Drugs for P2RX7 Gene - From: ApexBio, DGIdb, IUPHAR, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ivermectin Approved, Vet_approved Pharma activator NAChR/purinergic P2X4 receptor modulator 57
DECAVANADATE Pharma Antagonist 0
KN62 Pharma Antagonist 0
A 438079 hydrochloride Pharma P2X7 receptor antagonist,competitive and selective, Competitive P2X7 antagonist 0
A 804598 Pharma P2X7 antagonist,potent and selective, Potent and selective P2X7 antagonist 0

(21) Additional Compounds for P2RX7 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ATPgammaS tetralithium salt

(5) Tocris Compounds for P2RX7 Gene

Compound Action Cas Number
A 438079 hydrochloride Competitive P2X7 antagonist 899431-18-6
A 804598 Potent and selective P2X7 antagonist 1125758-85-1
ATPgammaS tetralithium salt P2 agonist; ATP (Cat. No. 3245) analog 93839-89-5
BzATP triethylammonium salt Photoaffinity label for ATPase; also P2X7 agonist and P2X1/P2Y1 partial agonist 112898-15-4
NF 449 Highly selective P2X1 antagonist 627034-85-9

(30) ApexBio Compounds for P2RX7 Gene

Compound Action Cas Number
2-Methylthioadenosine triphosphate tetrasodium salt 100020-57-3
A 438079 P2X7 receptor antagonist,competitive and selective 899507-36-9
A 438079 hydrochloride P2X7 receptor antagonist,competitive and selective 899431-18-6
A 804598 P2X7 antagonist,potent and selective 1125758-85-1
A 839977 P2X7 antagonist,potent and selective 870061-27-1
A-740003 P2X7 receptor antagonist 861393-28-4
ATPγS tetralithium salt 93839-89-5
AZ 10606120 dihydrochloride Potent P2X7 receptor antagonist 607378-18-7
AZ 11645373 Human P2X7 antagonist,potent and selective 227088-94-0
BzATP triethylammonium salt 112898-15-4
GW791343 dihydrochloride P2X7 allosteric modulator 1019779-04-4
GW791343 HCl P2X7 allosteric modulator 309712-55-8
iso-PPADS tetrasodium salt P2 purinoceptors antagonist, specific 207572-67-6
KN-62 CaM kinase II inhibitor 127191-97-3
KN-92 hydrochloride Inactive derivative of KN-93,control compound 1431698-47-3
KN-93 CaMKII inhibitor,selective and cometitive 139298-40-1
MRS 2219 14141-47-0
NF 023 104869-31-0
NF 110 111150-22-2
NF 157 104869-26-3
NF 279 202983-32-2
NF 449 purinergic receptor antagonist 627034-85-9
PPADS tetrasodium salt 192575-19-2
PPNDS 1021868-77-8
Purotoxin 1 1396322-38-5
Ro 0437626 134362-79-1
Ro 51 1050670-85-3
RO-3 1026582-88-6
Suramin hexasodium salt 129-46-4
TNP-ATP triethylammonium salt 61368-63-6
genes like me logo Genes that share compounds with P2RX7: view

Transcripts for P2RX7 Gene

Unigene Clusters for P2RX7 Gene

Purinergic receptor P2X, ligand-gated ion channel, 7:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for P2RX7 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - - - -
SP9: - - - - - -
SP10: -
SP11: - - - - - -
SP12: - -
SP13: - - -

Relevant External Links for P2RX7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for P2RX7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for P2RX7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RX7 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.7), Brain - Substantia nigra (x4.2), and Brain - Hippocampus (x4.1).

Protein differential expression in normal tissues from HIPED for P2RX7 Gene

This gene is overexpressed in Frontal cortex (33.5), Spinal cord (14.5), and Bone (10.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for P2RX7 Gene

Protein tissue co-expression partners for P2RX7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of P2RX7 Gene:


SOURCE GeneReport for Unigene cluster for P2RX7 Gene:


mRNA Expression by UniProt/SwissProt for P2RX7 Gene:

Tissue specificity: Widely expressed with highest levels in brain and immune tissues.
genes like me logo Genes that share expression patterns with P2RX7: view

Primer Products

Orthologs for P2RX7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RX7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia P2RX7 34 35
  • 99.72 (n)
(Canis familiaris)
Mammalia P2RX7 34 35
  • 88.22 (n)
(Bos Taurus)
Mammalia P2RX7 34 35
  • 85.66 (n)
(Mus musculus)
Mammalia P2rx7 34 16 35
  • 81.9 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia P2RX7 35
  • 68 (a)
(Gallus gallus)
Aves P2RX7 34 35
  • 57.52 (n)
(Anolis carolinensis)
Reptilia P2RX7 35
  • 56 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490828 34
  • 54.73 (n)
African clawed frog
(Xenopus laevis)
Amphibia p2X7 34
(Danio rerio)
Actinopterygii p2rx7 34 35
  • 54.88 (n)
-- 34
Species where no ortholog for P2RX7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RX7 Gene

Gene Tree for P2RX7 (if available)
Gene Tree for P2RX7 (if available)

Paralogs for P2RX7 Gene

Paralogs for P2RX7 Gene

genes like me logo Genes that share paralogs with P2RX7: view

Variants for P2RX7 Gene

Sequence variations from dbSNP and Humsavar for P2RX7 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_036444 A colorectal cancer sample
VAR_036445 A colorectal cancer sample
rs10160951 -- 121,180,454(+) AGTCC(C/G)AGTAA intron-variant, nc-transcript-variant, reference, missense
rs10627747 -- 121,148,188(+) TTTTT(-/ATTT/TTTA)ATTTA intron-variant
rs10657764 -- 121,147,599(+) TTTTT(-/TTG/TTTG)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for P2RX7 Gene

Variant ID Type Subtype PubMed ID
dgv307e214 CNV gain 21293372
dgv319e199 CNV deletion 23128226
esv26396 CNV gain 19812545
esv2746483 CNV deletion 23290073
esv2759917 CNV loss 17122850
esv3630934 CNV loss 21293372
esv3630940 CNV loss 21293372
esv3630941 CNV loss 21293372
esv3630942 CNV loss 21293372
esv3630943 CNV loss 21293372
nsv1054878 CNV gain 25217958
nsv1127298 CNV deletion 24896259
nsv521928 CNV gain 19592680
nsv560454 CNV loss 21841781
nsv560455 CNV gain 21841781
nsv832531 CNV gain 17160897

Variation tolerance for P2RX7 Gene

Residual Variation Intolerance Score: 96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 21.94; 99.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RX7 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RX7 Gene

Disorders for P2RX7 Gene

MalaCards: The human disease database

(6) MalaCards diseases for P2RX7 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
extrapulmonary tuberculosis
  • eptb
chronic lymphocytic leukemia
  • b-cell chronic lymphocytic leukemia
root resorption
n syndrome
  • nsx
pulmonary tuberculosis
  • ptb
- elite association - COSMIC cancer census association via MalaCards
Search P2RX7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for P2RX7

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with P2RX7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RX7 Gene

Publications for P2RX7 Gene

  1. The permeabilizing ATP receptor, P2X7. Cloning and expression of a human cDNA. (PMID: 9038151) Rassendren F. … Surprenant A. (J. Biol. Chem. 1997) 2 3 4 22 64
  2. Functional variants of the P2RX7 gene, aseptic osteolysis, and revision of the total hip arthroplasty: a preliminary study. (PMID: 19891999) Mrazek F. … Petrek M. (Hum. Immunol. 2010) 3 22 46 64
  3. P2X7 gene polymorphisms and risk assessment for pulmonary tuberculosis in Asian Indians. (PMID: 20164546) Sambasivan V. … Hasan Q. (Dis. Markers 2010) 3 22 46 64
  4. Lack of association between polymorphisms in the P2X7 gene and tuberculosis in a Chinese Han population. (PMID: 19076224) Xiao J. … Shen A. (FEMS Immunol. Med. Microbiol. 2009) 3 22 46 64
  5. Palmitoylation of the P2X7 receptor, an ATP-gated channel, controls its expression and association with lipid rafts. (PMID: 18971257) Gonnord P. … Kanellopoulos J.M. (FASEB J. 2009) 3 4 22 64

Products for P2RX7 Gene

Sources for P2RX7 Gene

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