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Aliases & Descriptions for P2RX6
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC129625 1, 2 | | P2RXL1 2, 3 | | P2X6 1, 2, 3 | | P2XM 1, 2, 3 |
| | | Descriptions |
|---|
| ATP receptor 2, 3 | | Purinergic receptor 3 | | Purinergic receptor P2X-like 1 3 | | purinergic receptor P2X, ligand-gated ion channel, 6 2 | | purinergic receptor P2X-like 1, orphan receptor 1, 2 | | purinergic receptor P2X6 2 | | purinoceptor P2X6 2 | | purinoreceptor P2X6 2 | | skeletal muscle-expressed P2X 2 |
|
| | Search outside databases for aliases for P2RX6 gene |
Summaries for P2RX6(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for P2RX6: The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 22, has been identified. [provided by RefSeq] UniProtKB/Swiss-Prot: P2RX6_HUMAN, O15547Function: Receptor for ATP that acts as a ligand gated ion channel (By similarity)Gene Wiki entry for P2RX6 |
Genomic Location for P2RX6
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q11.21 Ensembl cytogenetic band: 22q11.21 HGNC cytogenetic band: 22q11.21P2RX6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P019699:
(about GC identifiers)
Start:
|
19,699,316 bp from pter |
End:
|
19,713,119 bp from pter |
Size:
|
13,804 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000022.9 NT_011520.11
| Proteins for P2RX6
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: P2RX6_HUMAN, O15547 (See
protein sequence)Recommended Name: P2X purinoceptor 6 Size: 431 amino acids; 47913 Da
Subunit: Homo- or heteropolymers (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q58F04 Q6IC33 Q9UL50REFSEQ proteins (2 alternative transcripts):
NP_001153026.1 NP_005437.2
ENSEMBL proteins: ENSP00000385309 ENSP00000338797 ENSP00000383997
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for P2RX6: Assays for P2RX6: | Protein
Domains/ Families for P2RX6(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O15547
ProtoNet protein and cluster: O15547 2 Blocks protein families: IPB001429 ATP P2X receptor IPB003049 P2X6 purinoceptor signature
UniProtKB/Swiss-Prot: P2RX6_HUMAN, O15547Similarity: Belongs to the P2X receptor family | Gene Function for P2RX6
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005446
Applied Biosystems Silencer® siRNAs for P2RX6
Sigma-Aldrich siRNA and siRNA Panels for P2RX6  Sigma-Aldrich shRNA for P2RX6  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005446                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005446                                  untagged cDNA clones in CMV expression vector (see all 4): NM_005446 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005446
UniProtKB/Swiss-Prot: P2RX6_HUMAN, O15547Function: Receptor for ATP that acts as a ligand gated ion channel (By similarity)1 MGI phenotypic allele for P2rx6 (no phenotypes)
5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7
): About this table | Pathways & Interactions for P2RX6
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/19 Interacting proteins for P2RX6 (ENSP000003387973) via UniProtKB, MINT, and/or STRING (see all 19
)About this table
3 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for P2RX6(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for P2RX6 available from Tocris Bioscience About this table
1 Novoseek chemical compound relationship for P2RX6 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| atp |
52.48 |
3 |
16242142 (1), 10633863 (1) |
About this table
|
Transcripts for P2RX6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005446
Sigma-Aldrich siRNA and siRNA Panels for P2RX6  Sigma-Aldrich shRNA for P2RX6  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005446 REFSEQ mRNAs for P2RX6 gene (2 alternative transcripts): NM_001159554.1 NM_005446.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005446               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005446                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005446                                  untagged cDNA clones in CMV expression vector (see all 4): NM_005446  Additional cDNA sequence: AB002058.1 AK309079.1 BC033488.1 BC047287.1 BC063553.1 BC064805.1 BC109209.2 CR456535.1 7 DOTS entries: DT.204083 DT.102840440 DT.120668072 DT.101966541 DT.120667846 DT.120667933 DT.100779540 24/37 AceView cDNA sequences (see all 37
):BC064805 H55214 BM696978 BC047287 BG820544 AI356622 NM_005446 BC033488 BM668009 BX338022 BI753477 BC063553 BF529980 AI096436 AI703080 AB002058 BI821165 CF131935 BX280306 BI757011 CD676001 CR456535 BX359188 CD620488 Unigene Cluster for P2RX6: Purinergic receptor P2X, ligand-gated ion channel, 6 Hs.113275 [show with all ESTs]Unigene Representative Sequence: AB002058
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for P2RX6 (see all 8
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13 | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | - |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |
| SP4: | |   | |   | |   | - |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for P2RX6
3 Ensembl transcripts including schematic representations: ENST00000401443
ENST00000336296
ENST00000402329
|
Expression for P2RX6
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| P2RX6 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for P2RX6
1 / 2 5 probe-sets matching P2RX6 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCTGGACAAA
SOURCE GeneReport for Unigene cluster: Hs.113275 UniProtKB/Swiss-Prot: P2RX6_HUMAN, O15547Tissue specificity: Expressed predominantly in skeletal muscle |
Orthologs for P2RX6
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for P2RX6 gene from 5 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
P2RX61 |
-- |
purinergic receptor P2X, ligand-gated ion channel, more |
80.87(n) 77.99(a) |
486436 XM_543562.1 XP_543562.1 |
chimpanzee (Pan troglodytes) |
P2RX61 |
-- |
purinergic receptor P2X, ligand-gated ion channel, more |
99.17(n) 99.09(a) |
745626 XM_001168351.1 XP_001168351.1 |
cow (Bos taurus) |
P2RX61 |
-- |
purinergic receptor P2X, ligand-gated ion channel, more |
83.94(n) 82.29(a) |
618262 XM_870593.2 XP_875686.2 |
rat (Rattus norvegicus) |
P2rx61 |
-- |
purinergic receptor P2X, ligand-gated ion channel, more |
81.58(n) 80.86(a) |
25041 NM_012721.1 NP_036853.1 |
mouse (Mus musculus) |
P2rx61, 5 |
165
|
purinergic receptor P2X, ligand-gated ion channel, more1, 5 |
82.84(n)1 83.56(a)1 |
184401 NM_011028.11 NP_035158.11 AB0108835 AK0813085 (see all 9) |
About this table Species with no ortholog for P2RX6
ENSEMBL Gene Tree for P2RX6 | Paralogs for P2RX6(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for P2RX6 gene
- P2RX52 P2RX12 P2RX42 P2RX72
|
SNPs/Variants for P2RX6(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for P2RX6 (up to first 250kb)
|
Disorders & Mutations for P2RX6
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608077
Human Genome Epidemiology Navigator: P2RX6 (4 documents)
|
Medical News for P2RX6(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for P2RX6 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/30 PubMed articles for P2RX6 gene (see all 30
):- Cloning of P2XM, a novel human P2X receptor gene regulated by p53. (PubMed id 9242461)2, 3, 4 Urano T....Tokino T. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)3, 4 Collins J.E.... Dunham I. (2004)
- Identification of the phosphotyrosine proteome from thrombin activated platelets. (PubMed id 12112843)3, 4 Maguire P.B....Fitzgerald D.J. (2002)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2, 3 Dunham I....O'Brien K.P. (1999)
- Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. (PubMed id 8786426)1, 2 Collo G....Buell G. (1996)
- Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes. (PubMed id 18852390)1, 3 Palomino-Doza J....Keavney B. (2008)
- Gene variants associated with ischemic stroke: the cardiovascular health study. (PubMed id 19023099)3 Luke M.M....Psaty B.M. (2009)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)3 Trynka G....Wijmenga C. (2009)
- Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study. (PubMed id 17975119)3 Shiffman D....Psaty B.M. (2008)
|
Search for P2RX6
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing P2RX6
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing P2RX6
(According to HUGE)
About This Section
| -- |
Specialized Databases showing P2RX6(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/P2X_receptor |
|
| | | About This Section
| --
| Services for P2RX6(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for P2RX6:

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| | Recombinant Proteins (P2X6) | | Antibodies (P2X6) |
| | | Tocris compounds for P2RX6 |
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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