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P2RX4 Gene

protein-coding GIFtS: 65

GC12P120110

purinergic receptor P2X, ligand-gated ion channel, 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
P2X4 ^¹, ², ³, ⁵
P2X4R ^²

Descriptions
ATP receptor ^², ³
ATP-gated cation channel protein ^²
P2X purinoceptor 4 ^²
P2X receptor, subunit 4 ^²
Purinergic receptor ^³
purinergic receptor P2X, ligand-gated ion channel, 4 ^²
purinergic receptor P2X4 ^²
purinoceptor P2X4 ^²

External Ids
HGNC: 8535¹
Entrez Gene: 5025²
UniProtKB: Q99571³
Ensembl: ENSG00000135124⁷

Search outside databases for aliases for P2RX4 gene

Previous GC identifers: GC12P120510 GC12P121227 GC12P121430 GC12P120059

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for P2RX4:

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as

a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction

between the members of the purinoceptor family is the relative sensitivity to the antagonists

suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists.

Multiple alternatively spliced transcript variants have been identified for this gene although

their full-length natures have not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: P2RX4_HUMAN, Q99571

Function: Receptor for ATP that acts as a ligand gated ion channel. This receptor is insensitive to

the antagonists PPADS and suramin

Gene Wiki entry for P2RX4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the P2RX4 gene

Entrez Gene cytogenetic band: 12q24.32 Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.32

P2RX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P120110: (about GC identifiers)

Start:	120,132,047 bp from pter
End:	120,156,292 bp from pter
Size:	24,246 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_009775.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: P2RX4_HUMAN, Q99571 (See protein sequence)

Recommended Name: P2X purinoceptor 4

Size: 388 amino acids; 43369 Da

Subunit: Homo- or heteropolymers (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: O00450 O14722 Q5U090 Q8N4N1 Q9UBG9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002551.2

ENSEMBL proteins:

ENSP00000336607 ENSP00000353032

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (P2RX4)
	Human Recombinant Proteins from Abnova (P2RX4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	ISS	17785580
GO:0005887	integral to plasma membrane	TAS	9016352
GO:0030054	cell junction	IDA	12088286
GO:0048471	perinuclear region of cytoplasm	IDA	12088286

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Antibodies for P2RX4:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of P2RX4
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (P2RX4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (P2RX4)
	Novus Biologicals Antibodies for P2RX4

Assays for P2RX4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q99571

ProtoNet protein and cluster: Q99571

2 Blocks protein families:

IPB001429 ATP P2X receptor

IPB003047 P2X4 purinoceptor signature

UniProtKB/Swiss-Prot: P2RX4_HUMAN, Q99571

Similarity: Belongs to the P2X receptor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RX4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RX4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002560

Applied Biosystems Silencer® siRNAs for P2RX4

Sigma-Aldrich siRNA and siRNA Panels for P2RX4

Sigma-Aldrich shRNA Panels and shRNA for P2RX4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for P2RX4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002560
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002560
untagged cDNA clones in CMV expression vector (see all 3): NM_002560

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002560

UniProtKB/Swiss-Prot: P2RX4_HUMAN, Q99571

Function: Receptor for ATP that acts as a ligand gated ion channel. This receptor is insensitive to

the antagonists PPADS and suramin

Genatlas biochemistry entry for P2RX4:

purinoceptor,P2X4,ionotropic class,expressed in heart and spinal cord

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for P2rx4):

homeostasis/metabolism

immune system

nervous system

renal/urinary system

5/11 Gene Ontology (GO) molecular function terms (links to tree view) (see all 11 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001614	purinergic nucleotide receptor activity	IMP	11606481
GO:0004872	receptor activity	IEA	--
GO:0004931	ATP-gated cation channel activity	IDA	9016352
GO:0005102	receptor binding	ISS	17785580
GO:0005216	ion channel activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for P2RX4

5/27 Interacting proteins for P2RX4 (ENSP00000336607³) via UniProtKB, MINT, and/or STRING (see all 27 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
P2RY2	ENSP00000310305³	STRING (score=.927)
BMI1	ENSP00000365909³	STRING (score=.899)
CHAF1B	ENSP00000315700³	STRING (score=.899)
H3F3A	ENSP00000355781³	STRING (score=.899)
RING1	ENSP00000363787³	STRING (score=.899)

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5/18 Gene Ontology (GO) biological process terms (links to tree view) (see all 18 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001894	tissue homeostasis	NAS	17264311
GO:0002028	regulation of sodium ion transport	ISS	17785580
GO:0006811	ion transport	IEA	--
GO:0007165	signal transduction	IDA	9016352
GO:0008217	regulation of blood pressure	IMP	11606481 15130891

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for P2RX4 available from Tocris Bioscience

Compound	Action	CAS number
iso-PPADS tetrasodium salt	P2X antagonist
NF 023	Selective, competitive P2X antagonist	[104869-31-0]
Ivermectin	Allosteric modulator of alpha7 nicotinic receptors	[70288-86-7]
2-Methylthioadenosine triphosphate tetrasodium salt	P2 purinergic agonist	[43170-89-4]
TNP-ATP triethylammonium salt	Potent, selective P2X antagonist	[61368-63-6]

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5 Novoseek chemical compound relationships for P2RX4 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	74.62	16	17299767 (3), 10969036 (3), 9151945 (2), 10414359 (1) (see all 10)
2-methylthio-atp	54.58	1	15208093 (1)
calcium	32.66	4	17043813 (2), 17325195 (1), 16000699 (1)
oxygen	0.00	2	16344139 (1), 12849743 (1)
glucose	0.00	3	16344139 (1), 12437584 (1), 12849743 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RX4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RX4)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002560

Sigma-Aldrich siRNA and siRNA Panels for P2RX4

Sigma-Aldrich shRNA Panels and shRNA for P2RX4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002560

REFSEQ mRNAs for P2RX4 gene:

NM_002560.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002560

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002560
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002560
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_002560

Additional cDNA sequence:

AF000234.1 AF012903.1 AK225604.1 AK293599.1 AK293660.1 AK297704.1 AK301080.1 AK308549.1

AK308868.1 BC017458.1 BC033826.1 BT019738.1 BT019739.1 CR609333.1 CR613665.1 CR613673.1

CR623433.1 DQ851491.1 U83993.1 Y07684.1

12 DOTS entries:

DT.114444 DT.100719202 DT.100691479 DT.95205863 DT.100775312 DT.102836348 DT.100773570 DT.100017747

DT.95205851 DT.97793813 DT.97794658 DT.121195527

24/164 AceView cDNA sequences (see all 164 ):

CR613665 AI082452 AW024997 NM_175567 AI190193 BM837866 AU076568 BC017458

BM055367 BU169682 BF061015 BM055168 AW295511 CK903225 BI765438 CR609333

BU681981 AA337884 BQ221383 BM988100 BG621230 BI518531 BQ221852 NM_002560

highest scoring ESTs for P2RX4:

U83993 AA298113 AA302820 AA337884 AA359184 AA452596 AA630980 AA677220 AA700841 AA838236

Unigene Cluster for P2RX4:

Purinergic receptor P2X, ligand-gated ion channel, 4

Hs.321709 [show with all ESTs]

Unigene Representative Sequence: AK308868

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for P2RX4 (see all 9 )

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13a	·	13b	^	14
SP1:											-								-		-														-						-
SP2:																			-		-
SP3:											-								-		-		-
SP4:											-								-
SP5:											-		-						-		-

About this scheme

ECgene alternative splicing isoforms for P2RX4

2 Ensembl transcripts including schematic representations:

ENST00000337233 ENST00000359949

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

P2RX4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for P2RX4

¹ / ² / ³

3 probe-sets matching P2RX4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38332_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U83993	1.00	1.00	1.00	1
204088_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002560	0.60	1.00	0.82	1
204088_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks P2RX4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CGGCAGAGCT

SOURCE GeneReport for Unigene cluster: Hs.321709
Expression variation in blood from EXPOLDB for P2RX4

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for P2RX4 gene from 5/8 species (see all 8 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	P2RX4¹	--	purinergic receptor P2X, ligand-gated ion channel, more	89(n) 89.95(a)	448783 XM_543389.2 XP_543389.1
chimpanzee (Pan troglodytes)	P2RX4¹	--	purinergic receptor P2X, ligand-gated ion channel, more	99.48(n) 100(a)	452319 XM_001164210.1 XP_001164210.1
cow (Bos taurus)	P2RX4¹	--	purinergic receptor P2X, ligand-gated ion channel, more	87.71(n) 87.37(a)	338036 NM_001034049.1 NP_001029221.1
rat (Rattus norvegicus)	P2rx4¹	--	purinergic receptor P2X, ligand-gated ion channel 4	86(n) 87.11(a)	29659 NM_031594.1 NP_113782.1
mouse (Mus musculus)	P2rx4^{1, 5}	5 (65.00 cM)⁵	purinergic receptor P2X, ligand-gated ion channel 4^{1, 5}	85.4(n)¹ 87.37(a)¹	18438¹ NM_011026.2¹ NP_035156.2¹ AA387605⁵ AF089751⁵ (see all 28)

About this table Species with no ortholog for P2RX4

ENSEMBL Gene Tree for P2RX4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for P2RX4 gene

P2RX5² P2RX1² P2RX6² P2RX7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/238 NCBI SNPs in P2RX4 are shown (see all 238 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 98)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11065501^1,2	A,C,F,H	120156353(+)	`ACAACC/GAGTAA`	1	--	ng3¹		9		EU EA WA NS	1267
	rs1653622^1,2	C,F,H	120131818(+)	`gcttcA/Gtctcc`	1	--	ng5¹		3		EA NS	591
	rs11065484^1,2	C,F,H	120130399(+)	`CATGGG/ACATCT`	1	--	ng5¹		4		EU EA WA	420
	rs25644^1,2	C,F,H	120151029(+)	`GACACA/GGTTTC`	1	S/G	mis¹		17		MN EA NA NS EU WA	3289
--	rs2686392^1,2	A,C	120156694(+)	`ATCCAC/TCTGCC`	1	--	ng3¹		0	--	--	--	--
	rs28360463^1,2	C,F	120131707(+)	`ATCTTC/ACCCGA`	1	--	ng5¹		3		NS MN EA	1679
	rs3183956^1,2	H	120155829(+)	`AATTTC/TTGGAA`	1	--	ut3¹ ese³		2		EA	176
	rs1044249^1,2	F	120132366(+)	`GCTGCG/TCCGCG`	1	A/S	mis¹ ese³		1		MN	184
--	rs28969487^1,2	F	120156471(+)	`GGCAGA/TGTCTC`	1	--	ng3¹		1		NS	427
--	rs28969488^1,2	F	120156472(+)	`GCAGAG/CTCTCA`	1	--	ng3¹		1		NS	427

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HapMap Linkage Disequilibrium images for P2RX4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600846

Genetic Association Database: P2RX4
Human Genome Epidemiology Navigator: P2RX4 (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/79 PubMed articles for P2RX4 gene (see all 79 ):

Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. (PubMed id 9016352)^{2, 3, 4} Garcia-Guzman M....Stuhmer W. (1997)
Genetic analysis of 22 candidate genes for hypertension in the Japanese population. (PubMed id 15167446)^{3, 6} Iwai N....Shioji K. (2004)
Dynamic regulation of the P2X4 receptor in alveolar macrophages by phagocytosis and classical activation. (PubMed id 19283779)^{1, 3} Stokes L. and Surprenant A. (2009)
Fluid shear stress activates Ca(2+) influx into human endothelial cells via P2X4 purinoceptors. (PubMed id 10969036)^{1, 3} Yamamoto K....Ando J. (2000)
Evidence for functional P2X4/P2X7 heteromeric receptors. (PubMed id 17785580)^{1, 3} Guo C....Murrell-Lagnado R.D. (2007)
Enhanced expression of the P2X4 receptor in Duchenne muscular dystrophy correlates with macrophage invasion. (PubMed id 15006691)^{1, 3} Yeung D....Gorecki D.C. (2004)
Sp1-mediated downregulation of P2X4 receptor gene transcription in endothelial cells exposed to shear stress. (PubMed id 11299224)^{1, 3} Korenaga R....Ando J. (2001)
cAMP potentiates ATP-evoked calcium signaling in human parotid acinar cells. (PubMed id 15262999)^{1, 3} Brown D.A....Yule D.I. (2004)
A beneficial role of cardiac P2X4 receptors in heart failure: rescue of the calsequestrin overexpression model of cardiomyopathy. (PubMed id 15130891)^{1, 3} Yang A....Liang B.T. (2004)
P2X(4) receptors mediate ATP-induced calcium influx in human vascular endothelial cells. (PubMed id 10899068)^{1, 3} Yamamoto K....Ando J. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 5025	HGNC: 8535	AceView: P2RX4	Ensembl:ENSG00000135124	euGenes: HUgn5025
ECgene: P2RX4	H-InvDB: P2RX4

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
Wikipedia	http://en.wikipedia.org/wiki/P2X_receptor

Licensable Technologies for P2RX4
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for P2RX4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for P2RX4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for P2RX4		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for P2RX4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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P2RX4 Gene

protein-coding GIFtS: 65

Aliases &
Descriptions
for P2RX4

Summaries
for P2RX4

Genomic Location
for P2RX4

Proteins
for P2RX4

Protein Domains/
Families
for P2RX4

Gene Function
for P2RX4

Pathways & Interactions
for P2RX4

Drugs & Compounds
for P2RX4

Transcripts
for P2RX4

Expression
for P2RX4

Orthologs
for P2RX4

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Medical News
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Services
for P2RX4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

P2RX4 Gene

protein-coding GIFtS: 65

Aliases & Descriptionsfor P2RX4

Summariesfor P2RX4

Genomic Locationfor P2RX4

Proteinsfor P2RX4

Protein Domains/Familiesfor P2RX4

Gene Functionfor P2RX4

Pathways & Interactionsfor P2RX4

Drugs & Compoundsfor P2RX4

Transcriptsfor P2RX4

Expression for P2RX4

Orthologsfor P2RX4

Paralogsfor P2RX4

SNPs/Variantsfor P2RX4

Disorders & Mutationsfor P2RX4

Medical Newsfor P2RX4

Publicationsfor P2RX4

Search for P2RX4

Genome Databases showing P2RX4

Other Databases showing P2RX4

Specialized Databases showing P2RX4

Licensable Technologiesfor P2RX4

Servicesfor P2RX4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for P2RX4

Summaries
for P2RX4

Genomic Location
for P2RX4

Proteins
for P2RX4

Protein Domains/
Families
for P2RX4

Gene Function
for P2RX4

Pathways & Interactions
for P2RX4

Drugs & Compounds
for P2RX4

Transcripts
for P2RX4

Expression
for P2RX4

Orthologs
for P2RX4

Paralogs
for P2RX4

SNPs/Variants
for P2RX4

Disorders & Mutations
for P2RX4

Medical News
for P2RX4

Publications
for P2RX4

Licensable Technologies
for P2RX4

Services
for P2RX4