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Aliases for P2RX4 Gene

Aliases for P2RX4 Gene

  • Purinergic Receptor P2X 4 2 3 5
  • ATP Receptor 3 4
  • P2X4 3 4
  • Purinergic Receptor P2X, Ligand-Gated Ion Channel, 4 2
  • Purinergic Receptor P2X, Ligand Gated Ion Channel, 4 3
  • ATP-Gated Cation Channel Protein 3
  • Purinergic Receptor P2X4 3
  • P2X Receptor, Subunit 4 3
  • Purinergic Receptor 4
  • P2X Purinoceptor 4 3
  • Purinoceptor P2X4 3
  • P2X4R 3

External Ids for P2RX4 Gene

Previous GeneCards Identifiers for P2RX4 Gene

  • GC12P120510
  • GC12P121227
  • GC12P121430
  • GC12P120059
  • GC12P120110
  • GC12P121647
  • GC12P118657
  • GC12P121229
  • GC12P121281
  • GC12P121337
  • GC12P121401
  • GC12P121465
  • GC12P121686

Summaries for P2RX4 Gene

Entrez Gene Summary for P2RX4 Gene

  • The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

GeneCards Summary for P2RX4 Gene

P2RX4 (Purinergic Receptor P2X 4) is a Protein Coding gene. Diseases associated with P2RX4 include Chronic Pain. Among its related pathways are Calcium signaling pathway and Response to elevated platelet cytosolic Ca2+. GO annotations related to this gene include protein homodimerization activity and ion channel activity. An important paralog of this gene is P2RX1.

UniProtKB/Swiss-Prot for P2RX4 Gene

  • Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.

Tocris Summary for P2RX4 Gene

  • P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains.

Gene Wiki entry for P2RX4 Gene

Additional gene information for P2RX4 Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RX4 Gene

Genomics for P2RX4 Gene

Regulatory Elements for P2RX4 Gene

Enhancers for P2RX4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H121196 1.7 FANTOM5 Ensembl ENCODE dbSUPER 43 -12.6 -12648 1 BCOR ATF1 JUN ZNF175 ZMYM3 MAX POLR2A EED ETV6 ATF7 P2RX4 P2RX7 CAMKK2 ACADS ENSG00000256569 OASL ENSG00000274029
GH12H121143 1.9 FANTOM5 Ensembl ENCODE dbSUPER 33.1 -65.3 -65305 2 PKNOX1 ARNT ZNF766 ATF7 RUNX3 CAVIN1 JUNB MEF2D ATF4 SMARCA4 P2RX4 P2RX7 ANAPC5 GCN1 SETD1B HNF1A-AS1 ENSG00000272849 CAMKK2 OASL ENSG00000257053
GH12H121276 1.8 FANTOM5 Ensembl ENCODE dbSUPER 30.5 +68.4 68436 3 TBL1XR1 BATF YY1 SCRT2 FOS ATF7 RUNX3 IKZF2 SMARCA5 USF2 P2RX4 CAMKK2 OASL P2RX7 LOC105370032
GH12H121059 1.4 FANTOM5 Ensembl ENCODE 27 -149.5 -149450 1 HDGF PKNOX1 ZBTB40 RAD21 YY1 ZNF143 ZNF207 ATF7 RUNX3 IKZF2 OASL P2RX4 P2RX7 C12orf43 SPPL3 ACADS ENSG00000256569 CAMKK2 LOC105378258
GH12H121212 1.4 Ensembl ENCODE dbSUPER 22.6 +6.4 6355 6 ELF3 PKNOX1 ATF1 NFXL1 RAD21 ZSCAN9 RARA YY1 ZNF121 GATA2 P2RX4 P2RX7 ACADS ENSG00000256569 LOC105370032 CAMKK2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around P2RX4 on UCSC Golden Path with GeneCards custom track

Promoters for P2RX4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000058420 543 1601 SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF766 ZNF143 ZNF207 SP3 SP5

Genomic Location for P2RX4 Gene

Chromosome:
12
Start:
121,209,857 bp from pter
End:
121,234,106 bp from pter
Size:
24,250 bases
Orientation:
Plus strand

Genomic View for P2RX4 Gene

Genes around P2RX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RX4 Gene

Proteins for P2RX4 Gene

  • Protein details for P2RX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99571-P2RX4_HUMAN
    Recommended name:
    P2X purinoceptor 4
    Protein Accession:
    Q99571
    Secondary Accessions:
    • E7EPF7
    • F6RU17
    • O00450
    • O14722
    • Q5U089
    • Q5U090
    • Q8N4N1
    • Q9UBG9

    Protein attributes for P2RX4 Gene

    Size:
    388 amino acids
    Molecular mass:
    43369 Da
    Quaternary structure:
    • Functional P2XRs are organized as homomeric and heteromeric trimers.

    Alternative splice isoforms for P2RX4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for P2RX4 Gene

Post-translational modifications for P2RX4 Gene

  • Glycosylation at Asn75, Asn110, Asn153, posLast=184184, posLast=199199, and Asn208
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for P2RX4 Gene

Domains & Families for P2RX4 Gene

Gene Families for P2RX4 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Graphical View of Domain Structure for InterPro Entry

Q99571

UniProtKB/Swiss-Prot:

P2RX4_HUMAN :
  • Belongs to the P2X receptor family.
Family:
  • Belongs to the P2X receptor family.
genes like me logo Genes that share domains with P2RX4: view

Function for P2RX4 Gene

Molecular function for P2RX4 Gene

GENATLAS Biochemistry:
purinoceptor,P2X4,ionotropic class,expressed in heart and spinal cord
UniProtKB/Swiss-Prot Function:
Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.

Phenotypes From GWAS Catalog for P2RX4 Gene

Gene Ontology (GO) - Molecular Function for P2RX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001614 purinergic nucleotide receptor activity IMP 11606481
GO:0004931 extracellular ATP-gated cation channel activity IDA,IEA 9016352
GO:0005102 receptor binding ISS 17785580
GO:0005216 ion channel activity IEA --
GO:0005507 copper ion binding ISS 12819199
genes like me logo Genes that share ontologies with P2RX4: view
genes like me logo Genes that share phenotypes with P2RX4: view

Animal Models for P2RX4 Gene

MGI Knock Outs for P2RX4:

Animal Model Products

  • Taconic Biosciences Mouse Models for P2RX4

CRISPR Products

miRNA for P2RX4 Gene

miRTarBase miRNAs that target P2RX4

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for P2RX4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RX4 Gene

Localization for P2RX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RX4 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for P2RX4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 5
nucleus 3
cytosol 3
cytoskeleton 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for P2RX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005639 integral component of nuclear inner membrane IBA --
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane ISS,TAS --
GO:0005887 integral component of plasma membrane IMP,IEA 10515189
GO:0014069 postsynaptic density IEA --
genes like me logo Genes that share ontologies with P2RX4: view

Pathways & Interactions for P2RX4 Gene

genes like me logo Genes that share pathways with P2RX4: view

Pathways by source for P2RX4 Gene

2 Cell Signaling Technology pathways for P2RX4 Gene
1 Qiagen pathway for P2RX4 Gene

Gene Ontology (GO) - Biological Process for P2RX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001894 tissue homeostasis NAS 17264311
GO:0002028 regulation of sodium ion transport ISS 17785580
GO:0006810 transport IDA 9016352
GO:0006811 ion transport IEA --
GO:0007165 signal transduction IDA 9016352
genes like me logo Genes that share ontologies with P2RX4: view

No data available for SIGNOR curated interactions for P2RX4 Gene

Drugs & Compounds for P2RX4 Gene

(14) Drugs for P2RX4 Gene - From: DrugBank, ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Eslicarbazepine acetate Approved Pharma Target, antagonist 67
Ivermectin Approved, Vet_approved Pharma NAChR/purinergic P2X4 receptor modulator 67
KN-93 Pharma CaMKII inhibitor,selective and cometitive 0
A 438079 hydrochloride Pharma P2X7 receptor antagonist,competitive and selective, Competitive P2X7 antagonist 0
A 804598 Pharma P2X7 antagonist,potent and selective, Potent and selective P2X7 antagonist 0

(3) Additional Compounds for P2RX4 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ATPgammaS tetralithium salt
93839-89-5

(5) Tocris Compounds for P2RX4 Gene

Compound Action Cas Number
A 438079 hydrochloride Competitive P2X7 antagonist 899431-18-6
A 804598 Potent and selective P2X7 antagonist 1125758-85-1
ATPgammaS tetralithium salt P2 agonist; ATP (Cat. No. 3245) analog 93839-89-5
BzATP triethylammonium salt Photoaffinity label for ATPase; also P2X7 agonist and P2X1/P2Y1 partial agonist 112898-15-4
NF 449 Highly selective P2X1 antagonist 627034-85-9

(2) ApexBio Compounds for P2RX4 Gene

Compound Action Cas Number
Ivermectin NAChR/purinergic P2X4 receptor modulator 70288-86-7
KN-93 CaMKII inhibitor,selective and cometitive 139298-40-1
genes like me logo Genes that share compounds with P2RX4: view

Drug Products

Transcripts for P2RX4 Gene

Unigene Clusters for P2RX4 Gene

Purinergic receptor P2X, ligand-gated ion channel, 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for P2RX4
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for P2RX4 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14
SP1: - - - - -
SP2: - -
SP3: - - - -
SP4: - -
SP5: - - - -
SP6: - - - - -
SP7: -
SP8: -
SP9:

Relevant External Links for P2RX4 Gene

GeneLoc Exon Structure for
P2RX4
ECgene alternative splicing isoforms for
P2RX4

Expression for P2RX4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for P2RX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for P2RX4 Gene

This gene is overexpressed in Liver (22.4), Islet of Langerhans (10.6), and Placenta (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for P2RX4 Gene



NURSA nuclear receptor signaling pathways regulating expression of P2RX4 Gene:

P2RX4

SOURCE GeneReport for Unigene cluster for P2RX4 Gene:

Hs.321709

Evidence on tissue expression from TISSUES for P2RX4 Gene

  • Nervous system(4.5)
  • Blood(4.4)
  • Kidney(4.4)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with P2RX4: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for P2RX4 Gene

Orthologs for P2RX4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RX4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RX4 33 34
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia P2X4 34
  • 90 (a)
OneToOne
P2RX4 33
  • 89 (n)
cow
(Bos Taurus)
Mammalia P2RX4 33 34
  • 87.71 (n)
rat
(Rattus norvegicus)
Mammalia P2rx4 33
  • 86 (n)
mouse
(Mus musculus)
Mammalia P2rx4 33 16 34
  • 85.4 (n)
oppossum
(Monodelphis domestica)
Mammalia P2RX4 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia P2RX4 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves P2RX4 33 34
  • 74.67 (n)
lizard
(Anolis carolinensis)
Reptilia P2RX4 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia p2rx4 33
  • 68.5 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398206 33
zebrafish
(Danio rerio)
Actinopterygii p2rx4a 33 34
  • 61.28 (n)
p2rx4b 34
  • 50 (a)
OneToMany
Species where no ortholog for P2RX4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RX4 Gene

ENSEMBL:
Gene Tree for P2RX4 (if available)
TreeFam:
Gene Tree for P2RX4 (if available)

Paralogs for P2RX4 Gene

Paralogs for P2RX4 Gene

(7) SIMAP similar genes for P2RX4 Gene using alignment to 8 proteins:

genes like me logo Genes that share paralogs with P2RX4: view

Variants for P2RX4 Gene

Sequence variations from dbSNP and Humsavar for P2RX4 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000013156 -- 121,228,455(+) TGTGT(A/G)TATAT intron-variant
rs1000170918 -- 121,232,223(+) CCCCT(C/G)TACCT intron-variant
rs1000218023 -- 121,226,528(+) ACAGA(A/G)TAAGA intron-variant
rs1000280493 -- 121,226,971(+) TTAGC(C/G)AGGCG intron-variant
rs1000353493 -- 121,226,775(+) GAACA(A/C/T)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for P2RX4 Gene

Variant ID Type Subtype PubMed ID
nsv1054878 CNV gain 25217958
nsv455731 CNV loss 19166990
nsv521928 CNV gain 19592680
nsv560454 CNV loss 21841781
nsv560455 CNV gain 21841781
nsv560456 CNV loss 21841781

Variation tolerance for P2RX4 Gene

Residual Variation Intolerance Score: 46.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.90; 83.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RX4 Gene

Human Gene Mutation Database (HGMD)
P2RX4
SNPedia medical, phenotypic, and genealogical associations of SNPs for
P2RX4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for P2RX4 Gene

Disorders for P2RX4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for P2RX4 Gene - From: HGMD and GeneCards

Disorder Aliases PubMed IDs
chronic pain
  • pain - chronic
- elite association - COSMIC cancer census association via MalaCards
Search P2RX4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for P2RX4

Genetic Association Database (GAD)
P2RX4
Human Genome Epidemiology (HuGE) Navigator
P2RX4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
P2RX4
genes like me logo Genes that share disorders with P2RX4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RX4 Gene

Publications for P2RX4 Gene

  1. Ambulatory blood pressure is associated with polymorphic variation in P2X receptor genes. (PMID: 18852390) Palomino-Doza J … Keavney B (Hypertension (Dallas, Tex. : 1979) 2008) 3 22 45 60
  2. Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. (PMID: 9016352) Garcia-Guzman M … Stühmer W (Molecular pharmacology 1997) 2 3 4 60
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 45 60
  4. Amyloid-beta induces a caspase-mediated cleavage of P2X4 to promote purinotoxicity. (PMID: 19562525) Varma R … Haughey NJ (Neuromolecular medicine 2009) 3 22 60
  5. Functional evidence for the expression of P2X1, P2X4 and P2X7 receptors in human lung mast cells. (PMID: 19552691) Wareham K … Seward EP (British journal of pharmacology 2009) 3 22 60

Products for P2RX4 Gene

Sources for P2RX4 Gene

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