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Aliases & Descriptions for P2RX3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| MGC129956 2 | | P2X3 1, 2, 3, 5 |
| | | Descriptions |
|---|
| ATP receptor 2, 3 | | P2X purinoceptor 3 2 | | P2X receptor, subunit 3 2 | | Purinergic receptor 3 | | purinergic receptor P2X, ligand-gated ion channel, 3 2 | | purinergic receptor P2X3 2 | | purinoceptor P2X3 2 |
|
| | Search outside databases for aliases for P2RX3 genePrevious GC identifers: GC11P059499 GC11P058618 GC11P057356 GC11P056881 |
Summaries for P2RX3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for P2RX3: The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq] UniProtKB/Swiss-Prot: P2RX3_HUMAN, P56373Function: Receptor for ATP that acts as a ligand gated ion channelGene Wiki entry for P2RX3 |
Genomic Location for P2RX3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the P2RX3 gene 
Entrez Gene cytogenetic band: 11q12 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12P2RX3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P056862:
(about GC identifiers)
Start:
|
56,862,525 bp from pter |
End:
|
56,894,125 bp from pter |
Size:
|
31,601 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000011.8 NT_033903.7
| Proteins for P2RX3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: P2RX3_HUMAN, P56373 (See
protein sequence)Recommended Name: P2X purinoceptor 3 Size: 397 amino acids; 44230 Da
Subunit: Homo- or heteropolymers (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: Q9UQB6Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002550.2
ENSEMBL proteins: ENSP00000263314
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for P2RX3: Assays for P2RX3: | Protein
Domains/ Families for P2RX3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P56373
ProtoNet protein and cluster: P56373 2 Blocks protein families: IPB001429 ATP P2X receptor IPB003046 P2X3 purinoceptor signature
UniProtKB/Swiss-Prot: P2RX3_HUMAN, P56373Similarity: Belongs to the P2X receptor family | Gene Function for P2RX3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002559
Applied Biosystems Silencer® siRNAs for P2RX3
Sigma-Aldrich siRNA and siRNA Panels for P2RX3  Sigma-Aldrich shRNA Panels and shRNA for P2RX3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002559                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002559                                  untagged cDNA clone in CMV expression vector: NM_002559 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002559
UniProtKB/Swiss-Prot: P2RX3_HUMAN, P56373Function: Receptor for ATP that acts as a ligand gated ion channelGenatlas biochemistry entry for P2RX3:purinoceptor,P2X3,ionotropic class,expressed in heart and spinal cord,coexpressed with P2RX2 in sensory neurons,fibers,running into the spinal cord5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for P2rx3):
5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7
): About this table | Pathways & Interactions for P2RX3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for P2RX3 
5/21 Interacting proteins for P2RX3 (ENSP000002633143) via UniProtKB, MINT, and/or STRING (see all 21
)About this table
5/16 Gene Ontology (GO) biological process terms (links to tree view) (see all 16
): About this table
|
Drugs & Compounds for P2RX3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for P2RX3 available from Tocris Bioscience About this table
10 Novoseek chemical compound relationships for P2RX3 gene
About this table
|
Transcripts for P2RX3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002559
Sigma-Aldrich siRNA and siRNA Panels for P2RX3  Sigma-Aldrich shRNA Panels and shRNA for P2RX3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002559 REFSEQ mRNAs for P2RX3 gene: NM_002559.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002559               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002559                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002559                                  untagged cDNA clone in CMV expression vector: NM_002559  Additional cDNA sequence: AB016608.1 BC069162.1 BC074792.2 BC074793.2 BC109287.2 2 DOTS entries: DT.40126934 DT.99990187 10 AceView cDNA sequences:BC074793 BC074792 BC069162 BX116711 NM_002559 AI147403 BQ887878 AB016608 CD359708 Y07683
highest scoring ESTs for P2RX3:AB016608 BQ887878 Y07683 BC069162 BC074792 BC074793 NM_002559 AI147403 BC109287 BX116711 Unigene Cluster for P2RX3: Purinergic receptor P2X, ligand-gated ion channel, 3 Hs.146738 [show with all ESTs]Unigene Representative Sequence: NM_002559
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for P2RX3
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | |
| SP1: | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for P2RX3
1 Ensembl transcript including schematic representation: ENST00000263314
|
Expression for P2RX3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| P2RX3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for P2RX3
1 / 2 / 3 3 probe-sets matching P2RX3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AAGACCTGCC
SOURCE GeneReport for Unigene cluster: Hs.146738
Expression variation in blood from EXPOLDB for P2RX3 |
Orthologs for P2RX3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for P2RX3 gene from 5/7 species (see all 7
)
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
dog (Canis familiaris) |
P2RX31 |
-- |
purinergic receptor P2X, ligand-gated ion channel, more |
90.26(n) 94.71(a) |
448782 XM_540614.1 XP_540614.1 |
chimpanzee (Pan troglodytes) |
P2RX31 |
-- |
purinergic receptor P2X, ligand-gated ion channel, more |
99.58(n) 99.75(a) |
742961 XM_001136930.1 XP_001136930.1 |
cow (Bos taurus) |
P2RX31 |
-- |
purinergic receptor P2X, ligand-gated ion channel, more |
88.82(n) 92.88(a) |
530468 XM_608941.3 XP_608941.3 |
rat (Rattus norvegicus) |
P2rx31 |
-- |
purinergic receptor P2X, ligand-gated ion channel, more |
88.25(n) 93.7(a) |
81739 NM_031075.1 NP_112337.1 |
mouse (Mus musculus) |
P2rx31, 5 |
25
|
purinergic receptor P2X, ligand-gated ion channel, more1, 5 |
89(n)1 93.7(a)1 |
2281391 NM_145526.21 NP_663501.21 AK0530215 AK1402835 (see all 8) |
About this table Species with no ortholog for P2RX3
ENSEMBL Gene Tree for P2RX3 | Paralogs for P2RX3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for P2RX3 gene
- P2RX22
|
SNPs/Variants for P2RX3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for P2RX3 (up to first 250kb)
|
Disorders & Mutations for P2RX3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 600843
3 Novoseek disease relationships for P2RX3 gene
About this table
|
Medical News for P2RX3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for P2RX3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/89 PubMed articles for P2RX3 gene (see all 89
): |
Search for P2RX3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing P2RX3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing P2RX3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing P2RX3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/P2X_receptor |
|
| | | About This Section
| --
| Services for P2RX3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for P2RX3:

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| | Recombinant Proteins (P2X3) | | Antibodies (P2X3) |
| | | Tocris compounds for P2RX3 |
|
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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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