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Aliases for P2RX3 Gene

Aliases for P2RX3 Gene

  • Purinergic Receptor P2X 3 2 3
  • Purinergic Receptor P2X, Ligand-Gated Ion Channel, 3 2 3
  • Purinergic Receptor P2X, Ligand Gated Ion Channel, 3 3 5
  • ATP Receptor 3 4
  • P2X3 3 4
  • Purinergic Receptor P2X3 3
  • P2X Receptor, Subunit 3 3
  • Purinergic Receptor 4
  • Purinoceptor P2X3 3

External Ids for P2RX3 Gene

Previous GeneCards Identifiers for P2RX3 Gene

  • GC11P059499
  • GC11P058618
  • GC11P056881
  • GC11P056862
  • GC11P057105
  • GC11P053454

Summaries for P2RX3 Gene

Entrez Gene Summary for P2RX3 Gene

  • The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]

GeneCards Summary for P2RX3 Gene

P2RX3 (Purinergic Receptor P2X 3) is a Protein Coding gene. Diseases associated with P2RX3 include interstitial cystitis and cystitis. Among its related pathways are Platelet activation, signaling and aggregation and CREB Pathway. GO annotations related to this gene include ion channel activity and extracellular ATP-gated cation channel activity. An important paralog of this gene is P2RX1.

UniProtKB/Swiss-Prot for P2RX3 Gene

  • Receptor for ATP that acts as a ligand-gated ion channel.

Tocris Summary for P2RX3 Gene

  • P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains.

Gene Wiki entry for P2RX3 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for P2RX3 Gene

Genomics for P2RX3 Gene

Regulatory Elements for P2RX3 Gene

Promoters for P2RX3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around P2RX3 on UCSC Golden Path with GeneCards custom track

Genomic Location for P2RX3 Gene

Chromosome:
11
Start:
57,335,946 bp from pter
End:
57,372,399 bp from pter
Size:
36,454 bases
Orientation:
Plus strand

Genomic View for P2RX3 Gene

Genes around P2RX3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
P2RX3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for P2RX3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for P2RX3 Gene

Proteins for P2RX3 Gene

  • Protein details for P2RX3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56373-P2RX3_HUMAN
    Recommended name:
    P2X purinoceptor 3
    Protein Accession:
    P56373
    Secondary Accessions:
    • Q6DK37
    • Q9UQB6

    Protein attributes for P2RX3 Gene

    Size:
    397 amino acids
    Molecular mass:
    44289 Da
    Quaternary structure:
    • Functional P2XRs are organized as homomeric and heteromeric trimers.

neXtProt entry for P2RX3 Gene

Proteomics data for P2RX3 Gene at MOPED

Post-translational modifications for P2RX3 Gene

  • Glycosylation at Asn 139, Asn 170, Asn 194, and Asn 290
  • Modification sites at PhosphoSitePlus

Other Protein References for P2RX3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for P2RX3 Gene

Domains & Families for P2RX3 Gene

Gene Families for P2RX3 Gene

Protein Domains for P2RX3 Gene

Suggested Antigen Peptide Sequences for P2RX3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56373

UniProtKB/Swiss-Prot:

P2RX3_HUMAN :
  • Belongs to the P2X receptor family.
Family:
  • Belongs to the P2X receptor family.
genes like me logo Genes that share domains with P2RX3: view

Function for P2RX3 Gene

Molecular function for P2RX3 Gene

GENATLAS Biochemistry:
purinoceptor,P2X3,ionotropic class,expressed in heart and spinal cord,coexpressed with P2RX2 in sensory neurons,fibers,running into the spinal cord
UniProtKB/Swiss-Prot Function:
Receptor for ATP that acts as a ligand-gated ion channel.
genes like me logo Genes that share phenotypes with P2RX3: view

Animal Models for P2RX3 Gene

MGI Knock Outs for P2RX3:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for P2RX3 Gene

Localization for P2RX3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for P2RX3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for P2RX3 Gene COMPARTMENTS Subcellular localization image for P2RX3 gene
Compartment Confidence
plasma membrane 5
nucleus 4
endoplasmic reticulum 3
extracellular 2
golgi apparatus 2
cytoskeleton 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for P2RX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005791 rough endoplasmic reticulum IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0043025 neuronal cell body IEA --
genes like me logo Genes that share ontologies with P2RX3: view

Pathways & Interactions for P2RX3 Gene

genes like me logo Genes that share pathways with P2RX3: view

Pathways by source for P2RX3 Gene

Interacting Proteins for P2RX3 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000263314%0d%0a9606.ENSP00000343339%0d%0a9606.ENSP00000442349%0d%0a
Selected Interacting proteins: ENSP00000263314 P56373-P2RX3_HUMAN for P2RX3 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for P2RX3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport TAS 9221902
GO:0006811 ion transport IEA --
GO:0007165 signal transduction TAS 9221902
GO:0007274 neuromuscular synaptic transmission IEA --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with P2RX3: view

No data available for SIGNOR curated interactions for P2RX3 Gene

Drugs & Compounds for P2RX3 Gene

(18) Drugs for P2RX3 Gene - From: Novoseek, IUPHAR, DGIdb, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
BzATP Pharma Full agonist, Agonist 0
TNP-ATP Pharma Antagonist 0
A317491 Pharma Antagonist 0
AF353 Pharma Antagonist 0
RO3 Pharma Antagonist 0

(9) Additional Compounds for P2RX3 Gene - From: IUPHAR, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alphabeta-meATP
Full agonist, Agonist
2-Methylthioadenosine triphosphate tetrasodium salt
100020-57-3
alpha,beta-Methyleneadenosine 5'-triphosphate trisodium salt
1343364-54-4
ATP disodium salt
987-65-5
ATPgammaS tetralithium salt
93839-89-5
genes like me logo Genes that share compounds with P2RX3: view

Transcripts for P2RX3 Gene

mRNA/cDNA for P2RX3 Gene

Unigene Clusters for P2RX3 Gene

Purinergic receptor P2X, ligand-gated ion channel, 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for P2RX3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2:
SP3:

Relevant External Links for P2RX3 Gene

GeneLoc Exon Structure for
P2RX3
ECgene alternative splicing isoforms for
P2RX3

Expression for P2RX3 Gene

mRNA expression in normal human tissues for P2RX3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for P2RX3 Gene

This gene is overexpressed in Testis (x27.7) and Heart - Left Ventricle (x13.0).

Protein differential expression in normal tissues from HIPED for P2RX3 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for P2RX3 Gene



SOURCE GeneReport for Unigene cluster for P2RX3 Gene Hs.146738

genes like me logo Genes that share expression patterns with P2RX3: view

Protein tissue co-expression partners for P2RX3 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for P2RX3 Gene

Orthologs for P2RX3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for P2RX3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia P2RX3 35
  • 99.58 (n)
  • 99.75 (a)
P2RX3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia P2RX3 36
  • 90 (a)
OneToOne
P2RX3 35
  • 87.99 (n)
  • 91.44 (a)
dog
(Canis familiaris)
Mammalia P2RX3 35
  • 90.26 (n)
  • 94.71 (a)
P2X3 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia P2rx3 16
P2rx3 36
  • 94 (a)
OneToOne
P2rx3 35
  • 89 (n)
  • 93.7 (a)
oppossum
(Monodelphis domestica)
Mammalia P2RX3 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia P2RX3 36
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia P2rx3 35
  • 88.33 (n)
  • 93.95 (a)
chicken
(Gallus gallus)
Aves LOC423134 35
  • 71.57 (n)
  • 71.07 (a)
P2RX3 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia P2RX3 36
  • 76 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii p2rx3b 36
  • 66 (a)
OneToOne
p2rx3b 35
  • 66.58 (n)
  • 69.47 (a)
Species with no ortholog for P2RX3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for P2RX3 Gene

ENSEMBL:
Gene Tree for P2RX3 (if available)
TreeFam:
Gene Tree for P2RX3 (if available)

Paralogs for P2RX3 Gene

Paralogs for P2RX3 Gene

(6) SIMAP similar genes for P2RX3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with P2RX3: view

Variants for P2RX3 Gene

Sequence variations from dbSNP and Humsavar for P2RX3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2276038 - 57,369,951(-) TCTCC(A/G/T)CTGTG nc-transcript-variant, reference, missense
rs879646 -- 57,356,722(+) ATATG(C/T)GTTAA intron-variant
rs1837974 -- 57,355,471(-) CCCAG(C/G)TACTG intron-variant
rs2003065 -- 57,349,233(-) CACCC(A/G/T)TCTCG intron-variant
rs2003858 -- 57,347,206(+) AGAGG(A/T)TGGGT intron-variant

Variation tolerance for P2RX3 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.25; 81.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for P2RX3 Gene

HapMap Linkage Disequilibrium report
P2RX3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for P2RX3 Gene

Disorders for P2RX3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for P2RX3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
interstitial cystitis
  • trigonitis
cystitis
  • infective cystitis
bladder disease
  • urinary bladder disease
low compliance bladder
  • hyperactivity of bladder
- elite association - COSMIC cancer census association via MalaCards
Search P2RX3 in MalaCards View complete list of genes associated with diseases

Relevant External Links for P2RX3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
P2RX3
genes like me logo Genes that share disorders with P2RX3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for P2RX3 Gene

Publications for P2RX3 Gene

  1. Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. (PMID: 9016352) Garcia-Guzman M. … Stuhmer W. (Mol. Pharmacol. 1997) 3 4 67
  2. Expression of P2X3 purinoceptors in suburothelial myofibroblasts of the normal human urinary bladder. (PMID: 19456993) Liu F. … Yamaguchi O. (Int. J. Urol. 2009) 3 23
  3. Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain. (PMID: 12885270) Jarvis M.F. (Expert Opin. Ther. Targets 2003) 3 23
  4. Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp. (PMID: 14520770) Renton T. … Anand P. (J Orofac Pain 2003) 3 23
  5. Molecular characterization and pharmacological properties of the human P2X3 purinoceptor. (PMID: 9221902) Garcia-Guzman M. … Soto F. (Brain Res. Mol. Brain Res. 1997) 2 3

Products for P2RX3 Gene

Sources for P2RX3 Gene

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