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P2RX3 Gene

protein-coding   GIFtS: 61
GCID: GC11P057105

Purinergic Receptor P2X, Ligand-Gated Ion Channel, 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Purinergic Receptor P2X, Ligand-Gated Ion Channel, 31 2     P2X Receptor, Subunit 32
P2X32 3 5     Purinergic Receptor P2X32
ATP Receptor2 3     Purinoceptor P2X32
P2X Purinoceptor 32     Purinergic Receptor3

External Ids:    HGNC: 85341   Entrez Gene: 50242   Ensembl: ENSG000001099917   OMIM: 6008435   UniProtKB: P563733   

Export aliases for P2RX3 gene to outside databases

Previous GC identifers: GC11P059499 GC11P058618 GC11P057356 GC11P056881 GC11P056862 GC11P053454


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for P2RX3 Gene:
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated
ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is
important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume
reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic
potential in pain relief and in the treatment of disorders of urine storage. (provided by RefSeq, Jul 2008)

GeneCards Summary for P2RX3 Gene:
P2RX3 (purinergic receptor P2X, ligand-gated ion channel, 3) is a protein-coding gene. Diseases associated with P2RX3 include burning mouth syndrome, and burns. GO annotations related to this gene include extracellular ATP-gated cation channel activity and purinergic nucleotide receptor activity. An important paralog of this gene is P2RX5.

UniProtKB/Swiss-Prot: P2RX3_HUMAN, P56373
Function: Receptor for ATP that acts as a ligand-gated ion channel

summary for P2RX3 Gene:
P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP.
Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two
transmembrane domains, a large extracellular loop and intracellular C- and N-termini. Receptors can be
formed from triplets of identical subunits (homomeric) and can also exist as heteromers. With the exception
of P2X6, all subunits can form homomeric receptors. P2X receptors have a wide distribution throughout the
body, including the central, peripheral and autonomic nervous systems, smooth muscle, heart and leukocytes.
They are involved in a range of physiological processes such as modulation of synaptic transmission,
vascular tone, cardiac rhythm and contractility and nociception.

Gene Wiki entry for P2RX3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000011.10  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the P2RX3 gene promoter:
         Pax-5   Lmo2   GATA-1   Egr-4   E47   PPAR-gamma1   HFH-1   Hand1   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidP2RX3 promoter sequence
   Search Chromatin IP Primers for P2RX3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat P2RX3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12   Ensembl cytogenetic band:  11q12.1   HGNC cytogenetic band: 11q12

P2RX3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
P2RX3 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P057105:  view genomic region     (about GC identifiers)

Start:
57,105,841 bp from pter      End:
57,138,073 bp from pter
Size:
32,233 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: P2RX3_HUMAN, P56373 (See protein sequence)
Recommended Name: P2X purinoceptor 3  
Size: 397 amino acids; 44289 Da
Subunit: Functional P2XRs are organized as homomeric and heteromeric trimers (By similarity)
Secondary accessions: Q6DK37 Q9UQB6

Explore the universe of human proteins at neXtProt for P2RX3: NX_P56373

Explore proteomics data for P2RX3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn139, Asn170, Asn194, Asn290
  • Modification sites at PhosphoSitePlus

  • See P2RX3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002550.2  
    ENSEMBL proteins: 
     ENSP00000263314   ENSP00000434166  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    P2R: Purinergic receptors
    P2RX: Ligand-gated ion channels / Purinergic receptors, ionotropic

    IUPHAR Guide to PHARMACOLOGY protein family classification: P2X3
    P2X receptors

    3 InterPro protein domains:
     IPR027309 P2X_extracellular_dom
     IPR001429 P2X_purnocptor
     IPR003046 P2X3_purnocptor

    Graphical View of Domain Structure for InterPro Entry P56373

    ProtoNet protein and cluster: P56373

    2 Blocks protein domains:
    IPB001429 ATP P2X receptor
    IPB003046 P2X3 purinoceptor signature


    UniProtKB/Swiss-Prot: P2RX3_HUMAN, P56373
    Similarity: Belongs to the P2X receptor family


    P2RX3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: P2RX3_HUMAN, P56373
    Function: Receptor for ATP that acts as a ligand-gated ion channel

         Genatlas biochemistry entry for P2RX3:
    purinoceptor,P2X3,ionotropic class,expressed in heart and spinal cord,coexpressed with P2RX2 in sensory
    neurons,fibers,running into the spinal cord

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001614purinergic nucleotide receptor activity NAS17895406
    GO:0004931extracellular ATP-gated cation channel activity NAS17895406
    GO:0005216ion channel activity ----
    GO:0005524ATP binding NAS17895406
         
    P2RX3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for P2RX3:
     Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for P2rx3):
     behavior/neurological  cardiovascular system  homeostasis/metabolism  immune system  integument 
     mortality/aging  nervous system  respiratory system 

    P2RX3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out P2rx3tm1Ckn for P2RX3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for P2RX3
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    P2RX3_HUMAN, P56373: Membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    endoplasmic reticulum2
    extracellular2
    golgi apparatus2
    cytoskeleton1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005639integral component of nuclear inner membrane IBA--
    GO:0005791rough endoplasmic reticulum IEA--
    GO:0005794Golgi apparatus IEA--
    GO:0005887integral component of plasma membrane TAS9221902

    P2RX3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for P2RX3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1CREB Pathway
    Intracellular Calcium Signaling0.50
    2Peptide ligand-binding receptors
    Neuroactive ligand-receptor interaction0.36
    3Sodium channels and transporters inward current
    Sodium channels and transporters inward current
    4Potassium transporters inward current
    Potassium transporters inward current
    5Calcium signaling pathway
    Calcium signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for P2RX3
        Intracellular Calcium Signaling


    2 Kegg Pathways  (Kegg details for P2RX3):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction


    P2RX3 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for P2RX3
    Interactions:

        GeneGlobe Interaction Network for P2RX3

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for P2RX3 (P563733 ENSP000002633144) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    P2RX2Q9UBL93, ENSP000003433394I2D: score=1 STRING: ENSP00000343339
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001666response to hypoxia IEA--
    GO:0006810transport TAS9221902
    GO:0006811ion transport ----
    GO:0006812cation transport ----
    GO:0007165signal transduction TAS9221902

    P2RX3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for P2RX3 available from Tocris Bioscience    About this table
    CompoundAction CAS #
    ATPgammaS tetralithium saltP2 agonist; ATP (Cat. No. 3245) analog[93839-89-5]
    NF 449Highly selective P2X1 antagonist[389142-38-5]
    A 438079 hydrochlorideCompetitive P2X7 antagonist[899507-36-9]
    Purotoxin 1Potent P2X3 modulator[1396322-38-5]
    TNP-ATP triethylammonium salt Potent, selective P2X antagonist [61368-63-6]

    6 IUPHAR Ligands for P2RX3 (P2X3)    About this table
    LigandTypeActionAffinityPubmed IDs
    TNP-ATP
    AntagonistAntagonist8.99614197
    AF353
    AntagonistAntagonist820590629
    A317491
    AntagonistAntagonist7.512482951
    RO3
    AntagonistAntagonist7.516465177
    BzATP
    AgonistFull agonist7.5--
    alphabeta-meATP
    AgonistFull agonist7.5--

    Selected Novoseek inferred chemical compound relationships for P2RX3 gene (see all 16)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alpha,beta methylene atp 89.2 6 17351651 (1), 18048695 (1), 9723962 (1), 10836147 (1) (see all 6)
    tnp-atp 75.8 2 11093790 (1), 10836147 (1)
    bzatp 75.6 4 18048695 (3), 16373435 (1)
    atp 75.5 39 9723962 (3), 14520770 (2), 16093386 (2), 15993446 (2) (see all 28)
    ppads 68.8 1 18481265 (1)
    resiniferatoxin 62.5 3 15245821 (2)
    suramin 62.1 2 18481265 (1), 18242779 (1)
    adpbetas 59.3 1 17351651 (1)
    2-methylthio-atp 58.9 1 15208093 (1)
    capsaicin 35 4 14520770 (2), 18819020 (2)



    P2RX3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for P2RX3 gene: 
    NM_002559.3  

    Unigene Cluster for P2RX3:

    Purinergic receptor P2X, ligand-gated ion channel, 3
    Hs.146738  [show with all ESTs]
    Unigene Representative Sequence: NM_002559
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533436 ENST00000263314(uc001nju.3) ENST00000534820
    miRNA
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    Additional mRNA sequence: 

    AB016608.1 BC069162.1 BC074792.2 BC074793.2 BC109287.2 

    2 DOTS entries:

    DT.40126934  DT.99990187 

    10 AceView cDNA sequences:

    BC074792 BX116711 NM_002559 BC074793 BC069162 AI147403 CD359708 AB016608 
    BQ887878 Y07683 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for P2RX3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:              -                                   -                                             
    SP2:                                                                                                
    SP3:                                                                                                


    ECgene alternative splicing isoforms for P2RX3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    P2RX3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGACCTGCC
    P2RX3 Expression
    About this image


    P2RX3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Mononuclear Myocytes Hyoid Arch Muscles
     
     Brain (Nervous System)
             Medulla Oblongata
     
     Testis (Reproductive System)
    P2RX3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    P2RX3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.146738
        Custom PCR Arrays for P2RX3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for P2RX3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for P2RX3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia P2rx31 , 5 purinergic receptor P2X, ligand-gated ion channel, more1, 5 89(n)1
    93.7(a)1
      2 (49.45 cM)5
    2281391  NM_145526.21  NP_663501.21 
     849985835 
    chicken
    (Gallus gallus)
    Aves LOC4231341 proteoglycan 2, bone marrow-like 71.57(n)
    71.07(a)
      423134  XM_421065.4  XP_421065.3 
    lizard
    (Anolis carolinensis)
    Reptilia P2RX36
    purinergic receptor P2X, ligand-gated ion channel,...
    76(a)
    1 ↔ 1
    1(92073743-92112473)
    zebrafish
    (Danio rerio)
    Actinopterygii p2rx3b2 purinergic receptor P2X, ligand-gated ion channel, more 76.03(n)   387300  AY292651.1 


    ENSEMBL Gene Tree for P2RX3 (if available)
    TreeFam Gene Tree for P2RX3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for P2RX3 gene
    P2RX52  P2RX5-TAX1BP32  P2RX42  P2RX62  P2RX12  P2RX22  P2RX72  
    6 SIMAP similar genes for P2RX3 using alignment to 2 protein entries:     P2RX3_HUMAN (see all proteins):
    P2RX4    P2RX1    P2RX2    P2RX6    P2RX5    P2RX7

    P2RX3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for P2RX3 (see all 662)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1444109831,2
    C--57105387(+) GCTGGA/TGTTAG 1 -- us2k10--------
    rs1842344261,2
    --57105501(+) GGGACA/GGCGCA 1 -- us2k10--------
    rs1888483261,2
    C--57105670(+) AAACAA/C/GTAGAC 1 -- us2k10--------
    rs802814731,2
    --57105931(+) CCTCCA/GGGTCG 1 -- ut510--------
    rs1424435821,2
    --57105944(+) ATCTCA/GTCTCC 1 -- ut510--------
    rs2000809621,2
    --57106091(+) GGACCA/GTCGGG 2 I V mis10--------
    rs609720681,2
    C--57106173(+) CTGGCG/AGGGTG 1 -- int12Minor allele frequency- A:0.10WA 120
    rs1813051121,2
    C--57106182(+) TGGGCC/TGCCTG 1 -- int10--------
    rs1152005411,2
    F--57106213(+) TGCCTC/TGGTGC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1854327951,2
    --57106214(+) GCCTCA/GGTGCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for P2RX3 (57105841 - 57138073 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for P2RX3: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing P2RX3
    DNA2.0 Custom Variant and Variant Library Synthesis for P2RX3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600843    OMIM disorders: --

    13 diseases for P2RX3:    
    About MalaCards
    burning mouth syndrome    burns    chronic pain    fibromyalgia
    cystitis    epididymitis    migraine    hypoxia
    neuroblastoma    hypertension    neuronitis    pancreatitis
    prostatitis

    2 diseases from the University of Copenhagen DISEASES database for P2RX3:
    Interstitial cystitis     Migraine

    P2RX3 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for P2RX3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    overactive bladder 52.7 2 11412212 (1), 20335487 (1)
    hyperalgesia 48.4 1 18042830 (1)
    inflammation 0 1 14650754 (1)


    Export disorders for P2RX3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for P2RX3 gene, integrated from 10 sources (see all 116):
    (articles sorted by number of sources associating them with P2RX3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of recombinant human P2X4 receptor reveals pharmacological differences to the rat homologue. (PubMed id 9016352)1, 2 Garcia-Guzman M....Stuhmer W. (Mol. Pharmacol. 1997)
    2. Molecular characterization and pharmacological properties of the human P2X3 purinoceptor. (PubMed id 9221902)1, 3 Garcia-Guzman M....Soto F. (Brain Res. Mol. Brain Res. 1997)
    3. Expression of P2X3 purinoceptors in suburothelial myofibroblasts of the normal human urinary bladder. (PubMed id 19456993)1, 9 Liu F....Yamaguchi O. (Int. J. Urol. 2009)
    4. Capsaicin receptor VR1 and ATP purinoceptor P2X3 in painful and nonpainful human tooth pulp. (PubMed id 14520770)1, 9 Renton T....Anand P. (J Orofac Pain 2003)
    5. Contributions of P2X3 homomeric and heteromeric channels to acute and chronic pain. (PubMed id 12885270)1, 9 Jarvis M.F. (Expert Opin. Ther. Targets 2003)
    6. Subtype-specific control of P2X receptor channel signaling by ATP and Mg2+. (PubMed id 23959888)1 Li M....Swartz K.J. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    7. ATP binding site mutagenesis reveals different subunit stoichiometry of functional P2X2/3 and P2X2/6 receptors. (PubMed id 22378790)1 Hausmann R....Illes P. (J. Biol. Chem. 2012)
    8. P2X3 receptor expression by HEK cells conditions their survival. (PubMed id 22160848)1 Apicella L. and Fabbretti E. (Purinergic Signal. 2012)
    9. Prenatal expression of purinergic receptor P2X3 in human dorsal root ganglion. (PubMed id 22052556)1 Pan A....Li Z. (Purinergic Signal. 2012)
    10. Effects of nucleotide analogs at the P2X3 receptor and its mutants identify the agonist binding pouch. (PubMed id 22498660)1 Riedel T....Illes P. (Mol. Pharmacol. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5024 HGNC: 8534 AceView: P2RX3 Ensembl:ENSG00000109991 euGenes: HUgn5024
    ECgene: P2RX3 Kegg: 5024 H-InvDB: P2RX3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for P2RX3 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/P2X_receptor

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for P2RX3 gene:
    Search GeneIP for patents involving P2RX3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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