V3 here soon-try beta now


Gene Search (GeneCards Home)	\|	GeneCards Guide	\|	User Feedback	\|	Terms of Use	\|	Notice about third-party sites

P2RX2 Gene

protein-coding GIFtS: 56

GC12P131705

purinergic receptor P2X, ligand-gated ion channel, 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
MGC129601 ^²
P2X2 ^¹, ², ³

Descriptions
ATP receptor ^², ³
P2X Receptor, subunit 2 ^²
P2X purinoceptor 2 ^²
Purinergic receptor ^³
purinergic receptor P2X, ligand-gated ion channel, 2 ^²
purinergic receptor P2X2 ^²

External Ids
HGNC: 15459¹
Entrez Gene: 22953²
UniProtKB: Q9UBL9³
Ensembl: ENSG00000187848⁷

Search outside databases for aliases for P2RX2 gene

Previous GC identifers: GC00U990510 GC12M132628 GC12P132820 GC12P131434 GC12P131805

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for P2RX2:

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as

a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from

neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been

identified for this gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: P2RX2_HUMAN, Q9UBL9

Function: Binding of this ligand gated ion channel to ATP mediates synaptic transmission between

neurons and from neurons to smooth muscle

Gene Wiki entry for P2RX2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the P2RX2 gene

Entrez Gene cytogenetic band: 12q24.33 Ensembl cytogenetic band: 12q24.33 HGNC cytogenetic band: 12q24.33

P2RX2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P131705: (about GC identifiers)

Start:	131,705,476 bp from pter
End:	131,709,045 bp from pter
Size:	3,570 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.10 NT_024477.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: P2RX2_HUMAN, Q9UBL9 (See protein sequence)

Recommended Name: P2X purinoceptor 2

Size: 471 amino acids; 51754 Da

Subunit: Homo- or heteropolymers

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: A6NGB4 A6NH93 A6NHC2 A6NHU3 A6NIG9 Q6V9R6 Q9NR37 Q9NR38 Q9UHD5 Q9UHD6 Q9UHD7

Q9Y637 Q9Y638

Alternative splicing: 7 isoforms: Q9UBL9-1 Q9UBL9-2 Q9UBL9-3 Q9UBL9-4 Q9UBL9-5 Q9UBL9-6 Q9UBL9-7

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (6 alternative transcripts):

NP_036358.2 NP_057402.1 NP_733782.1 NP_733783.1 NP_777361.1 NP_777362.1

ENSEMBL proteins:

ENSP00000343339 ENSP00000373762 ENSP00000343904 ENSP00000345095 ENSP00000341419 ENSP00000344502

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Millipore Purified and/or Recombinant P2RX2 Protein
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (P2X2)
	Human Recombinant Proteins from Abnova (P2RX2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for P2RX2:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of P2RX2
	Sigma-Aldrich Antibodies for P2RX2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (P2X2), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for P2RX2

Assays for P2RX2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9UBL9

ProtoNet protein and cluster: Q9UBL9

2 Blocks protein families:

IPB001429 ATP P2X receptor

IPB003045 P2X2 purinoceptor signature

UniProtKB/Swiss-Prot: P2RX2_HUMAN, Q9UBL9

Similarity: Belongs to the P2X receptor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RX2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RX2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_016318

Applied Biosystems Silencer® siRNAs for P2RX2

Sigma-Aldrich siRNA and siRNA Panels for P2RX2

Sigma-Aldrich shRNA Panels and shRNA for P2RX2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_012226
Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_012226
untagged cDNA clones in CMV expression vector (see all 8): NM_012226

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_170683

UniProtKB/Swiss-Prot: P2RX2_HUMAN, Q9UBL9

Function: Binding of this ligand gated ion channel to ATP mediates synaptic transmission between

neurons and from neurons to smooth muscle

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for P2rx2):

lethality-postnatal

normal

5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001614	purinergic nucleotide receptor activity	NAS	17895406
GO:0004872	receptor activity	IEA	--
GO:0004931	ATP-gated cation channel activity	NAS	17895406
GO:0005524	ATP binding	IEA	--
GO:0015276	ligand-gated ion channel activity	TAS	9119082

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for P2RX2

5/21 Interacting proteins for P2RX2 (ENSP00000343339³) via UniProtKB, MINT, and/or STRING (see all 21 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
P2RX1	ENSP00000225538³	STRING (score=.929)
P2RX3	ENSP00000263314³	STRING (score=.928)
P2RY2	ENSP00000310305³	STRING (score=.888)
VSNL1	ENSP00000295156³	STRING (score=.887)
APBB1	ENSP00000299402³	STRING (score=.864)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IEA	--
GO:0010524	positive regulation of calcium ion transport into cytosol	NAS	17895406
GO:0050850	positive regulation of calcium-mediated signaling	NAS	17895406

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Compounds for P2RX2 available from Tocris Bioscience

Compound	Action	CAS number
RO-3	Selective P2X2 and P2X2/3 antagonist
iso-PPADS tetrasodium salt	P2X antagonist
NF 023	Selective, competitive P2X antagonist	[104869-31-0]
Evans Blue tetrasodium salt	Potent inhibitor of L-glutamate uptake into synaptic vesicles	[314-13-6]
TNP-ATP triethylammonium salt	Potent, selective P2X antagonist	[61368-63-6]

About this table

6 Novoseek chemical compound relationships for P2RX2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tnp-atp	80.61	2	9575290 (1), 10836147 (1)
atp	75.82	34	8730726 (3), 9723962 (3), 15193425 (2), 15331685 (2) (see all 21)
adp	40.39	2	9614197 (1), 14581175 (1)
calcium	30.99	8	9723962 (3), 9625864 (2), 11287325 (1)
zinc	11.52	7	10322050 (4), 18242779 (1), 9151945 (1)
oxygen	0.00	1	12849743 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RX2)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RX2)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6): NM_016318

Sigma-Aldrich siRNA and siRNA Panels for P2RX2

Sigma-Aldrich shRNA Panels and shRNA for P2RX2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_012226 NM_016318 NM_170682 NM_170683 NM_174872 NM_174873

REFSEQ mRNAs for P2RX2 gene (6 alternative transcripts):

NM_012226.3 NM_016318.2 NM_170682.2 NM_170683.2 NM_174872.1 NM_174873.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_012226 NM_016318 NM_170682 NM_170683 NM_174872 NM_174873

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6): NM_012226
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 6): NM_012226
                                 untagged cDNA clones in CMV expression vector (see all 8): NM_012226

Additional cDNA sequence:

AF109387.1 AF109388.1 AF190822.1 AF190823.1 AF190824.1 AF190825.1 AF260426.1 AF260427.1

AF260428.1 AF260429.1 AY346374.1 BC109200.2 BC152398.1

6 DOTS entries:

DT.40190073 DT.91749700 DT.91792073 DT.95088400 DT.95338160 DT.99949252

18 AceView cDNA sequences:

NM_174872 AF260429 AY346374 AF190823 AF260427 NM_170682 AF190824 NM_012226

AF260426 NM_170683 AF260428 NM_174873 NM_016318 AF190825 AF109387 AF190822

AF109388 AA961509

highest scoring ESTs for P2RX2:

AA961509 AF109387 AF109388 AF190822 AF190823 AF190824 AF190825 AF260426 AF260427 AF260428

Unigene Cluster for P2RX2:

Purinergic receptor P2X, ligand-gated ion channel, 2

Hs.258580 [show with all ESTs]

Unigene Representative Sequence: NM_170683

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for P2RX2 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8	^	9a	·	9b	^	10	^	11	^	12a	·	12b	·	12c
SP1:																									-
SP2:																									-
SP3:									-				-												-
SP4:																									-
SP5:

About this scheme

ECgene alternative splicing isoforms for P2RX2

6 Ensembl transcripts including schematic representations:

ENST00000343948 ENST00000389110 ENST00000350048 ENST00000348800 ENST00000352418 ENST00000351222

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

P2RX2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for P2RX2

¹ / ² / ³

8 probe-sets matching P2RX2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
221372_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_012226	0.60	1.00	0.82	1
224069_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF260426	0.80	1.00	0.91	1
221356_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016318	0.60	1.00	0.82	1
224557_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AF190825	0.80	1.00	0.91	1
221372_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224069_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221356_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224557_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: AACAAAAACA

SOURCE GeneReport for Unigene cluster: Hs.258580

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for P2RX2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	P2RX2¹	--	purinergic receptor P2X, ligand-gated ion channel, more	85.47(n) 85.4(a)	448781 XM_843662.1 XP_848755.1
cow (Bos taurus)	P2RX2¹	--	purinergic receptor P2X, ligand-gated ion channel, more	87.4(n) 86.89(a)	527499 XM_605891.3 XP_605891.2
rat (Rattus norvegicus)	P2rx2¹	--	purinergic receptor P2X, ligand-gated ion channel, more	83.04(n) 82.24(a)	114115 NM_053656.2 NP_446108.2
mouse (Mus musculus)	P2rx2^{1, 5}	5⁵	purinergic receptor P2X, ligand-gated ion channel, more^{1, 5}	83.55(n)¹ 81.7(a)¹	231602¹ NM_153400.3¹ NP_700449.2¹ AB094663⁵ AB094664⁵ (see all 10)
zebrafish (Danio rerio)	p2rx2²	--	purinergic receptor P2X, ligand-gated ion channel, more	75.68(n)	387297 AY292650.1

About this table Species with no ortholog for P2RX2

ENSEMBL Gene Tree for P2RX2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for P2RX2 gene

P2RX3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/43 NCBI SNPs in P2RX2 are shown (see all 43 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 39)

AB	SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs7973007^1,2	A,C	131708982(+)	`AACCTC/TGAATC`	6	--	ut3¹ ese³		0	--	--	--	--
--	rs6560890^1,2	A,C	131705384(+)	`GAGCTA/Ccccgc`	6	--	ng5¹		0	--	--	--	--
--	rs6560889^1,2	A,C	131705208(+)	`GGCCCA/CCACCT`	6	--	ng5¹		0	--	--	--	--
	rs7964634^1,2	A,C	131706669(+)	`AGGACC/TGGGCG`	6	T/T	syn¹ ese³		0	--	--	--	--
	rs6560891^1,2	A,C,F,H	131707091(+)	`CTCCTA/GCCGCC`	6	--	int¹		4		EU EA WA	398
	rs7955816^1,2	A,C	131706806(+)	`TTTCCC/TCTGAC`	6	--	int¹ trp³		0	--	--	--	--
	rs4883632^1,2	A,C	131708094(-)	`ACGGCA/GTCTGA`	6	--	int¹		0	--	--	--	--
--	rs12830746^1,2	A	131707567(+)	`GCCCTC/TGTGAC`	6	--	int¹		0	--	--	--	--
--	rs7964872^1,2	C	131706846(+)	`CAAGAG/TCTGGG`	6	--	int¹		0	--	--	--	--
--	rs12815447^1,2	A	131707580(+)	`CCTTCC/TCTGGC`	6	--	int¹ trp³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for P2RX2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600844

2 Novoseek disease relationships for P2RX2 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
pheochromocytoma	13.60	2	8755603 (1), 15536175 (1)
epilepsy	0.00	1	12941474 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/91 PubMed articles for P2RX2 gene (see all 91 ):

Molecular and functional characterization of human P2X(2) receptors. (PubMed id 10570044)^{1, 2, 3, 4} Lynch K.J.... Jarvis M.F. (1999)
New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. (PubMed id 7523952)^{2, 3} Brake A.J....Julius D. (1994)
Cross-talk and co-trafficking between rho1/GABA receptors and ATP-gated channels. (PubMed id 14660627)^{1, 3} Boue-Grabot E....Garret M. (2004)
Cysteine Substitution Mutagenesis and the Effects of Methanethiosulfonate Reagents at P2X2 and P2X4 Receptors Support a Core Common Mode of ATP Action at P2X Receptors. (PubMed id 18487206)^{1, 3} Roberts J.A....Evans R.J. (2008)
Selective modulation of ligand-gated P2X purinoceptor channels by acute hypoxia is mediated by reactive oxygen species. (PubMed id 15331767)^{1, 3} Mason H.S....Kemp P.J. (2004)
Go it alone no more--P2X7 joins the society of heteromeric ATP-gated receptor channels. (PubMed id 17895406)^{1, 3} Dubyak G.R. (2007)
Molecular physiology of P2X receptors. (PubMed id 12270951)^{1, 3} North R.A. (2002)
Regulation of P2X2 receptors by the neuronal calcium sensor VILIP1. (PubMed id 18922787)³ Chaumont S....Khakh B.S. (2008)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)⁴ Scherer S.E.... Gibbs R.A. (2006)
Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize. (PubMed id 15657042)³ Barrera N.P....Edwardson J.M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 22953	HGNC: 15459	AceView: P2RX2	Ensembl:ENSG00000187848	euGenes: HUgn22953
ECgene: P2RX2	H-InvDB: P2RX2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/P2X_receptor

Licensable Technologies for P2RX2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for P2RX2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for P2RX2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for P2RX2		Antibodies for P2RX2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for P2RX2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (P2RX2)
	Search for Antibodies
	Chimera RNAi (P2RX2)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Search for Antibodies & Assays

	Recombinant Proteins (P2X2)
	Antibodies (P2X2)

Search OriGene for P2RX2

Tocris compounds for P2RX2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for P2RX2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

Random Gene From GIFtS :

about GIFtS

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Developed at the Crown Human Genome Center & Weizmann Institute of Science

The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
P2RX2 Gene at Home site.
Version 2.41.1
server5.xennexinc.com

P2RX2 Gene

protein-coding GIFtS: 56

Aliases &
Descriptions
for P2RX2

Summaries
for P2RX2

Genomic Location
for P2RX2

Proteins
for P2RX2

Protein Domains/
Families
for P2RX2

Gene Function
for P2RX2

Pathways & Interactions
for P2RX2

Drugs & Compounds
for P2RX2

Transcripts
for P2RX2

Expression
for P2RX2

Orthologs
for P2RX2

Paralogs
for P2RX2

SNPs/Variants
for P2RX2

Disorders & Mutations
for P2RX2

Medical News
for P2RX2

Publications
for P2RX2

Search for P2RX2

Genome Databases showing P2RX2

Other Databases showing P2RX2

Specialized Databases showing P2RX2

Licensable Technologies
for P2RX2

Services
for P2RX2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

P2RX2 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor P2RX2

Summariesfor P2RX2

Genomic Locationfor P2RX2

Proteinsfor P2RX2

Protein Domains/Familiesfor P2RX2

Gene Functionfor P2RX2

Pathways & Interactionsfor P2RX2

Drugs & Compoundsfor P2RX2

Transcriptsfor P2RX2

Expression for P2RX2

Orthologsfor P2RX2

Paralogsfor P2RX2

SNPs/Variantsfor P2RX2

Disorders & Mutationsfor P2RX2

Medical Newsfor P2RX2

Publicationsfor P2RX2

Search for P2RX2

Genome Databases showing P2RX2

Other Databases showing P2RX2

Specialized Databases showing P2RX2

Licensable Technologiesfor P2RX2

Servicesfor P2RX2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for P2RX2

Summaries
for P2RX2

Genomic Location
for P2RX2

Proteins
for P2RX2

Protein Domains/
Families
for P2RX2

Gene Function
for P2RX2

Pathways & Interactions
for P2RX2

Drugs & Compounds
for P2RX2

Transcripts
for P2RX2

Expression
for P2RX2

Orthologs
for P2RX2

Paralogs
for P2RX2

SNPs/Variants
for P2RX2

Disorders & Mutations
for P2RX2

Medical News
for P2RX2

Publications
for P2RX2

Licensable Technologies
for P2RX2

Services
for P2RX2