Aliases for P2RX2 Gene
External Ids for P2RX2 Gene
Previous HGNC Symbols for P2RX2 Gene
Previous GeneCards Identifiers for P2RX2 Gene
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Aug 2013]
GeneCards Summary for P2RX2 Gene
P2RX2 (Purinergic Receptor P2X, Ligand Gated Ion Channel, 2) is a Protein Coding gene. Diseases associated with P2RX2 include deafness, autosomal dominant 41 and neurogenic bladder. Among its related pathways are CREB Pathway and Calcium signaling pathway. GO annotations related to this gene include identical protein binding and copper ion binding. An important paralog of this gene is P2RX1.
UniProtKB/Swiss-Prot for P2RX2 Gene
Ion channel gated by extracellular ATP involved in a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle.
P2X receptors are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains, a large extracellular loop and intracellular C- and N-termini. Receptors can be formed from triplets of identical subunits (homomeric) and can also exist as heteromers. With the exception of P2X6, all subunits can form homomeric receptors. P2X receptors have a wide distribution throughout the body, including the central, peripheral and autonomic nervous systems, smooth muscle, heart and leukocytes. They are involved in a range of physiological processes such as modulation of synaptic transmission, vascular tone, cardiac rhythm and contractility and nociception.