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P2RX1 Gene

protein-coding GIFtS: 60

GC17M003746

purinergic receptor P2X, ligand-gated ion channel, 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
P2X1 ^¹, ², ³, ⁵

Descriptions
ATP receptor ^², ³
P2X purinoceptor 1 ^²
P2X receptor, subunit 1 ^²
P2X1 receptor ^²
Purinergic receptor ^³
purinergic receptor P2X, ligand-gated ion channel, 1 ^²
purinergic receptor P2X1 ^²

External Ids
HGNC: 8533¹
Entrez Gene: 5023²
UniProtKB: P51575³
Ensembl: ENSG00000108405⁷

Search outside databases for aliases for P2RX1 gene

Previous GC identifers: GC17M004112 GC17M003750 GC17M004006

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for P2RX1:

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as

a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates

synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for

example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse

studies suggest that this receptor is essential for normal male reproductive function. It is

possible that the development of selective antagonists for this receptor may provide an effective

non-hormonal male contraceptive pill. [provided by RefSeq]

UniProtKB/Swiss-Prot: P2RX1_HUMAN, P51575

Function: Ligand gated ion channel with relatively high calcium permeability. Binding to ATP

mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be

linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of

ATP, leading to programmed cell death (By similarity)

Gene Wiki entry for P2RX1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the P2RX1 gene

Entrez Gene cytogenetic band: 17p13.3 Ensembl cytogenetic band: 17p13.2 HGNC cytogenetic band: 17p13.3

P2RX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17M003746: (about GC identifiers)

Start:	3,746,634 bp from pter
End:	3,766,709 bp from pter
Size:	20,076 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000017.9 NT_010718.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: P2RX1_HUMAN, P51575 (See protein sequence)

Recommended Name: P2X purinoceptor 1

Size: 399 amino acids; 44980 Da

Subunit: Homo- or heteropolymers (By similarity)

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: Q9UK84

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_002549.1

ENSEMBL proteins:

ENSP00000225538

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (P2X1)
	Human Recombinant Proteins from Abnova (P2RX1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	9565569
GO:0019717	synaptosome	IEA	--
GO:0045121	membrane raft	IEA	--

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Antibodies for P2RX1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of P2RX1
	Sigma-Aldrich Antibodies for P2RX1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (P2X1), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for P2RX1

Assays for P2RX1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P51575

ProtoNet protein and cluster: P51575

2 Blocks protein families:

IPB001429 ATP P2X receptor

IPB003044 P2X1 purinoceptor signature

UniProtKB/Swiss-Prot: P2RX1_HUMAN, P51575

Similarity: Belongs to the P2X receptor family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RX1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RX1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002558

Applied Biosystems Silencer® siRNAs for P2RX1

Sigma-Aldrich siRNA and siRNA Panels for P2RX1

Sigma-Aldrich shRNA Panels and shRNA for P2RX1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for P2RX1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_002558
Myc/DDK tagged cDNA clone in CMV expression vector: NM_002558
untagged cDNA clone in CMV expression vector: NM_002558

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_002558

UniProtKB/Swiss-Prot: P2RX1_HUMAN, P51575

Function: Ligand gated ion channel with relatively high calcium permeability. Binding to ATP

mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be

linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of

ATP, leading to programmed cell death (By similarity)

Genatlas biochemistry entry for P2RX1:

purinoceptor,P2X1,ionotropic class,highly expressed in the platelets and a variety of tissues such

as bladder,peripheral leukocytes,pancreas,spleen etc...

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for P2rx1):

reproductive system

5/8 Gene Ontology (GO) molecular function terms (links to tree view) (see all 8 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001614	purinergic nucleotide receptor activity	IDA	8834001
GO:0004872	receptor activity	IEA	--
GO:0004931	ATP-gated cation channel activity	TAS	9565569
GO:0005262	calcium channel activity	EXP	2457808
GO:0005515	protein binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for P2RX1

5/23 Interacting proteins for P2RX1 (ENSP00000225538³) via UniProtKB, MINT, and/or STRING (see all 23 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
P2RY12	ENSP00000307259³	STRING (score=.959)
P2RX2	ENSP00000343339³	STRING (score=.929)
P2RY1	ENSP00000304767³	STRING (score=.922)
P2RY2	ENSP00000310305³	STRING (score=.87)
RYR3	ENSP00000354852³	STRING (score=.85)

About this table

5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006811	ion transport	IDA	8834001
GO:0006915	apoptosis	IEA	--
GO:0007165	signal transduction	TAS	9565569
GO:0008217	regulation of blood pressure	IEA	--
GO:0035249	synaptic transmission, glutamatergic	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Sigma-Aldrich Small Molecules for P2RX1:

Antagonist Agonist Inhibitor

Compounds for P2RX1 available from Tocris Bioscience

Compound	Action	CAS number
NF 279	Potent and selective P2X1 antagonist	[202983-32-2]
NF 449	Highly selective P2X1 antagonist	[389142-38-5]
NF 157	Selective P2Y11/P2X1 antagonist	[104869-26-3]
Ro 0437626	Selective P2X1 antagonist	[134362-79-1]
PPNDS	Potent, selective P2X1 antagonist

About this table

10/14 Novoseek chemical compound relationships for P2RX1 gene (see all 14 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
nf449	93.54	10	15792995 (4), 11521173 (3), 12787824 (2), 15579104 (1)
nf279	80.97	2	14625300 (1), 10550991 (1)
atp	78.66	80	11816716 (4), 14625300 (3), 14500714 (3), 16236030 (2) (see all 46)
nf023	77.46	4	10193905 (2), 12505158 (1)
adp	76.33	37	10395026 (3), 9565569 (2), 9442040 (2), 9423802 (2) (see all 23)
tnp-atp	71.64	2	12270951 (1), 10836147 (1)
2-methylthio-atp	65.01	1	19303093 (1)
adpbetas	54.06	2	11521173 (1)
calcium	47.02	29	10395026 (3), 9423802 (3), 8961184 (2), 16546137 (2) (see all 14)
thromboxane a2	31.71	3	17362227 (1), 11756171 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (P2RX1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (P2RX1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002558

Sigma-Aldrich siRNA and siRNA Panels for P2RX1

Sigma-Aldrich shRNA Panels and shRNA for P2RX1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_002558

REFSEQ mRNAs for P2RX1 gene:

NM_002558.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_002558

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002558
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002558
                                 untagged cDNA clone in CMV expression vector: NM_002558

Additional cDNA sequence:

AF020498.1 AK310981.1 AK313264.1 BC027949.1 BC044657.1 U45448.1 X83688.1

5 DOTS entries:

DT.205596 DT.91932377 DT.120974405 DT.97762701 DT.92036579

24/29 AceView cDNA sequences (see all 29 ):

BM469621 BF897001 NM_002558 BC044657 BI911608 BM805025 BX644575 BP374670

BP373442 BC027949 U45448 BP372168 BF897312 AF020498 X83688 BX101508

AI972443 BF903423 BF904867 BI054611 AW137646 BI030908 AI523608 BV184266

highest scoring ESTs for P2RX1:

U45448 AF020498 BC027949 BC044657 BI768515 BI911608 BQ072856 BX644575 X83688 AI523608

Unigene Cluster for P2RX1:

Purinergic receptor P2X, ligand-gated ion channel, 1

Hs.41735 [show with all ESTs]

Unigene Representative Sequence: BC027949

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for P2RX1

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9
SP1:									-
SP2:
SP3:
SP4:

About this scheme

ECgene alternative splicing isoforms for P2RX1

1 Ensembl transcript including schematic representation:

ENST00000225538

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

P2RX1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for P2RX1

¹ / ² / ³

3 probe-sets matching P2RX1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33535_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	U45448	1.00	1.00	1.00	1
210401_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U45448	1.00	1.00	1.00	1
210401_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks P2RX1 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.41735
Expression variation in blood from EXPOLDB for P2RX1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for P2RX1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	P2RX1¹	--	purinergic receptor P2X, ligand-gated ion channel, more	88.14(n) 90.73(a)	491223 XM_548344.1 XP_548344.1
chimpanzee (Pan troglodytes)	P2RX1¹	--	purinergic receptor P2X, ligand-gated ion channel, more	99.5(n) 99.75(a)	454439 XM_511276.2 XP_511276.2
cow (Bos taurus)	P2RX1¹	--	purinergic receptor P2X, ligand-gated ion channel, more	88.89(n) 89.47(a)	514898 XM_592814.2 XP_592814.2
rat (Rattus norvegicus)	P2rx1¹	--	purinergic receptor P2X, ligand-gated ion channel, more	85.88(n) 88.97(a)	25505 NM_012997.2 NP_037129.1
mouse (Mus musculus)	P2rx1^{1, 5}	11 (40.00 cM)⁵	purinergic receptor P2X, ligand-gated ion channel, more^{1, 5}	86.72(n)¹ 89.22(a)¹	18436¹ NM_008771.2¹ NP_032797.2¹ AF250121⁵ AF250122⁵ (see all 14)

About this table Species with no ortholog for P2RX1

ENSEMBL Gene Tree for P2RX1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for P2RX1 gene

P2RX5² P2RX4² P2RX6² P2RX7²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/155 NCBI SNPs in P2RX1 are shown (see all 155 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 69)

AB	SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs711173^1,2	A,C,F,H,O	3747744(-)	`CAGCCA/GGGCAG`	1	--	ut3¹ ese³		8	NA EA MN EU WA	854
	rs12600392^1,2	A,C,F,H	3767447(+)	`ATGAGG/AAAACC`	1	--	ng3¹		4	EU EA WA	396
	rs4995288^1,2	A,C,F,H	3768702(+)	`CAGTGC/TACCCC`	1	--	ng3¹		6	EU WA EA	646
--	rs6502752^1,2	A,C,F,H	3746667(+)	`CACCCC/GTCGCT`	1	--	ut3¹ ese³		4	EU EA WA	410
	rs4995289^1,2	A,C,F,H	3768668(+)	`AGCACT/CGTCTC`	1	--	ng3¹		4	EU EA WA	374
	rs11078477^1,2	A,C,F,H	3767081(+)	`TCACCG/AGTGCC`	1	--	ng3¹		4	EU EA WA	396
	rs3760474^1,2	C,F,H	3767762(-)	`ACTCCA/GCGAGG`	1	--	ng3¹		8	EU EA WA	834
	rs711174^1,2	A,C,F	3747829(-)	`TGGGTG/ACAGCG`	1	--	ut3¹ ese³		8	EA NA MN	416
	rs11078476^1,2	C,F,H	3766988(+)	`CCCCAC/GCTCTC`	1	--	ng3¹		4	EU EA WA	374
	rs12944845^1,2	C,F,H	3767813(+)	`AATCCG/AGAGAT`	1	--	ng3¹		8	EU EA WA	820

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HapMap Linkage Disequilibrium images for P2RX1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600845

UniProtKB/Swiss-Prot: P2RX1_HUMAN, P51575

Defects in P2RX1 are a cause of bleeding disorder [MIM:600845]

5 Novoseek disease relationships for P2RX1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
arterial thrombosis	32.88	1	16113781 (1)
bladder neurogenic	27.00	1	17169005 (1)
dilated cardiomyopathy	17.82	2	10451115 (1), 15686781 (1)
obstruction	0.00	2	17169005 (1), 11350400 (1)
bleeding	0.00	1	15792995 (1)

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Human Gene Mutation Database: P2RX1

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/148 PubMed articles for P2RX1 gene (see all 148 ):

Characterization and chromosomal localization of a human P2X receptor from the urinary bladder. (PubMed id 8834001)^{2, 3, 4} Valera S.... Buell G.N. (1995)
P2X1 purinoceptor in human platelets. Molecular cloning and functional characterization after heterologous expression. (PubMed id 9565569)^{1, 3, 4} Sun B.... Kambayashi J. (1998)
The human P2x1 receptor: molecular cloning, tissue distribution, and localization to chromosome 17. (PubMed id 8809107)^{1, 3, 4} Longhurst P.A.... Swanson R. (1996)
A natural dominant negative P2X1 receptor due to deletion of a single amino acid residue. (PubMed id 10816552)^{1, 3, 4} Oury C.... Hoylaerts M.F. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Conserved cysteine residues in the extracellular loop of the human P2X(1) receptor form disulfide bonds and are involved in receptor trafficking to the cell surface. (PubMed id 11809854)^{3, 4} Ennion S.J. and Evans R.J. (2002)
P2X1 stimulation promotes thrombin receptor-mediated platelet aggregation. (PubMed id 16634759)^{1, 3} Erhardt J.A....Johns D.G. (2006)
Sp1/3 and NF-1 mediate basal transcription of the human P2X1 gene in megakaryoblastic MEG-01 cells. (PubMed id 16529657)^{1, 3} Zhao J. and Ennion S.J. (2006)
P2X1 receptors are closely associated with connexin 43 in human ventricular myocardium. (PubMed id 15686781)^{1, 3} Jiang L....Burnstock G. (2005)
The ATP-gated P2X1 ion channel acts as a positive regulator of platelet responses to collagen. (PubMed id 11816716)^{1, 3} Oury C....Hoylaerts M.F. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5023	HGNC: 8533	AceView: P2RX1	Ensembl:ENSG00000108405	euGenes: HUgn5023
ECgene: P2RX1	H-InvDB: P2RX1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Wikipedia	http://en.wikipedia.org/wiki/P2X_receptor
Wikipedia	http://en.wikipedia.org/wiki/P2RX1

Licensable Technologies for P2RX1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for P2RX1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for P2RX1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for P2RX1		Antibodies for P2RX1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for P2RX1		Small molecules for P2RX1
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
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Tocris compounds for P2RX1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for P2RX1

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P2RX1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for P2RX1

Summaries
for P2RX1

Genomic Location
for P2RX1

Proteins
for P2RX1

Protein Domains/
Families
for P2RX1

Gene Function
for P2RX1

Pathways & Interactions
for P2RX1

Drugs & Compounds
for P2RX1

Transcripts
for P2RX1

Expression
for P2RX1

Orthologs
for P2RX1

Paralogs
for P2RX1

SNPs/Variants
for P2RX1

Disorders & Mutations
for P2RX1

Medical News
for P2RX1

Publications
for P2RX1

Search for P2RX1

Genome Databases showing P2RX1

Other Databases showing P2RX1

Specialized Databases showing P2RX1

Licensable Technologies
for P2RX1

Services
for P2RX1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

P2RX1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor P2RX1

Summariesfor P2RX1

Genomic Locationfor P2RX1

Proteinsfor P2RX1

Protein Domains/Familiesfor P2RX1

Gene Functionfor P2RX1

Pathways & Interactionsfor P2RX1

Drugs & Compoundsfor P2RX1

Transcriptsfor P2RX1

Expression for P2RX1

Orthologsfor P2RX1

Paralogsfor P2RX1

SNPs/Variantsfor P2RX1

Disorders & Mutationsfor P2RX1

Medical Newsfor P2RX1

Publicationsfor P2RX1

Search for P2RX1

Genome Databases showing P2RX1

Other Databases showing P2RX1

Specialized Databases showing P2RX1

Licensable Technologiesfor P2RX1

Servicesfor P2RX1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for P2RX1

Summaries
for P2RX1

Genomic Location
for P2RX1

Proteins
for P2RX1

Protein Domains/
Families
for P2RX1

Gene Function
for P2RX1

Pathways & Interactions
for P2RX1

Drugs & Compounds
for P2RX1

Transcripts
for P2RX1

Expression
for P2RX1

Orthologs
for P2RX1

Paralogs
for P2RX1

SNPs/Variants
for P2RX1

Disorders & Mutations
for P2RX1

Medical News
for P2RX1

Publications
for P2RX1

Licensable Technologies
for P2RX1

Services
for P2RX1