External Ids for OXTR Gene
The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]
GeneCards Summary for OXTR Gene
OXTR (Oxytocin Receptor) is a Protein Coding gene. Diseases associated with OXTR include atypical autism and adenomyosis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include peptide hormone binding and oxytocin receptor activity. An important paralog of this gene is AVPR1B.
UniProtKB/Swiss-Prot for OXTR Gene
Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system
Oxytocin receptors (OT) are G-protein-coupled receptors that mediate parturition and lactation. They are closely related to vasopressin receptors. Oxytocin receptors are coupled to Gq/11 proteins and are localized to the myoepithelial cells of the mammary gland, and are also expressed in the myometrium and endometrium of the uterus at the end of pregnancy. Oxytocin receptors are involved in smooth muscle contraction of the uterus during parturition and facilitate lactation. Oxytocin receptors are also widespread throughout the central nervous system and modulate a variety of behaviors. These include responses to stress and anxiety, social memory and recognition, bonding, and sexual and maternal behaviors. The human gene encoding the oxytocin receptor is localized to chromosome 3p25.