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OXTR Gene

protein-coding   GIFtS: 63

GC03M008767
oxytocin receptor
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
OT-R 2, 3
Descriptions
oxytocin receptor 2
External Ids
HGNC: 85291
Entrez Gene: 50212
UniProtKB: P305593
Ensembl: ENSG000001809147
Search outside databases for aliases for OXTR gene

Previous GC identifer: GC03M008721

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for OXTR:
The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a
receptor for oxytocin. Its activity is mediated by G proteins which activate a
phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays
an important role in the uterus during parturition. [provided by RefSeq]

UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559
Function: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which
activate a phosphatidylinositol-calcium second messenger system

Gene Wiki entry for OXTR (Oxytocin_receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the OXTR gene  

Entrez Gene cytogenetic band: 3p25   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25

OXTR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M008767:     (about GC identifiers)

Start:
8,767,094 bp from pter
End:
8,786,300 bp from pter
Size:
19,207 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000003.10  NT_022517.17  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559 (See protein sequence)
Recommended Name: Oxytocin receptor  
Size: 389 amino acids; 42772 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q15071

REFSEQ proteins: NP_000907.2  

ENSEMBL proteins: 
ENSP00000324270 


Human Recombinant Proteins 
Browse Drug Discovery Central at Invitrogen for human recombinant proteins
Millipore Purified and/or Recombinant OXTR Protein
Browse Human Recombinant Proteins at Sigma-Aldrich  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (Oxytocin Receptor)
Browse Abnova for Human Recombinant Proteins
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane TAS10858434 10910058
GO:0005887 integral to plasma membrane TAS10858434
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Antibodies for OXTR: 
Browse Antibodies Central at Invitrogen
Millipore Mono- and Polyclonal Antibodies for the study of OXTR
Sigma-Aldrich Antibodies for OXTR
Browse R&D Systems for Antibodies
Antibodies from Abcam (Oxytocin Receptor), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (OXTR)
Novus Biologicals Antibodies for OXTR

Assays for OXTR: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_supfam
 IPR002062 Oxytocn_rcpt
 IPR000276 7TM_GPCR_Rhodpsn
 IPR001817 Vasoprsn_rcpt


   GeneDecks  OXTR for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P30559

ProtoNet protein and cluster: P30559

2 Blocks protein families:
IPB001817 Vasopressin receptor signature
IPB002062 Oxytocin receptor signature


UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559
Similarity: Belongs to the G-protein coupled receptor 1 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OXTR)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (OXTR)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000916

              Applied Biosystems Silencer® siRNAs for OXTR

              Sigma-Aldrich siRNA and siRNA Panels for OXTR  
                     Sigma-Aldrich shRNA Panels and shRNA for OXTR  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Millipore Clones for the Expression of OXTR
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000916
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000916
                                 untagged cDNA clone in CMV expression vector: NM_000916 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_000916

UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559
Function: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which
activate a phosphatidylinositol-calcium second messenger system

Genatlas biochemistry entry for OXTR:
oxytocin receptor ,G protein coupled receptor superfamily

9 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Oxtr):

behavior/neurologicalendocrine/exocrine glandgrowth/sizemusclenervous system
no phenotypic analysisnormalreproductive systemskin/coat/nails

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004872 receptor activity IEA--
GO:0004930 G-protein coupled receptor activity IEA--
GO:0004990 oxytocin receptor activity TAS10858434
GO:0005000 vasopressin receptor activity IEA--
GO:0017046 peptide hormone binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Millipore Pathways for OXTR
 Selected targets of C/EBPbeta
 Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

   GeneDecks  OXTR for the pathways selected above  
About GeneDecksing

2 Kegg Pathways  (Kegg details for OXTR):
 hsa04020 Calcium signaling pathway
 hsa04080 Neuroactive ligand-receptor interaction

   GeneDecks  OXTR for the pathways selected above  
About GeneDecksing
 Gene Network CentralTM Interacting Genes and Proteins Network for  OXTR 


5/15 Interacting proteins for OXTR (ENSP000003242703) via UniProtKB, MINT, and/or STRING (see all 15 )
InteractantInteraction Details
GeneCardExternal ID(s)
OXTENSP000002173863STRING (score=.999)
AVPENSP000003696473STRING (score=.991)
GNAQENSP000002865483STRING (score=.842)
ESR2ENSP000003439253STRING (score=.828)
IL6ENSP000002587433STRING (score=.814)
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5 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0006936 muscle contraction TAS1313946
GO:0007186 G-protein coupled receptor protein signaling pathway IEA--
GO:0007565 female pregnancy TAS1313946
GO:0007595 lactation TAS1313946
GO:0045777 positive regulation of blood pressure IEA--
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Sigma-Aldrich Small Molecules for OXTR:
Antagonist

Compounds for OXTR available from Tocris Bioscience
10/33 Novoseek chemical compound relationships for OXTR gene (see all 33 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
ovta 82.70 3 12183418 (2), 15613460 (1)
carbetocin 80.21 5 15740719 (2), 15017343 (1)
barusiban 79.68 6 15740719 (3), 15350251 (1)
13,14-dihydro-15-ketoprostaglandin f2alpha 72.84 2 7616495 (1)
thr(4)-gly(7)-oxytocin 71.69 2 7895660 (1), 8836636 (1)
progesterone 66.74 95 8876043 (6), 12166628 (3), 11101280 (3), 8277221 (3) (see all 38)
prostaglandin 62.07 18 11241181 (3), 19050328 (2), 14973258 (2), 11101280 (2) (see all 12)
chapso 57.68 1 10785367 (1)
steroid 45.35 21 8776795 (2), 8396613 (2), 12436925 (2), 9548257 (2) (see all 14)
(+-)-pgf2-alpha 41.36 5 17205424 (1), 9675000 (1), 17459165 (1)
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1 PharmGKB drug compound relationship for OXTR gene
Drug compound PharmGKB Relations PubMed IDs for articles supporting these relationships
doxorubicinFA  11313874
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (OXTR)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (OXTR)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000916

              Sigma-Aldrich siRNA and siRNA Panels for OXTR  
                     Sigma-Aldrich shRNA Panels and shRNA for OXTR  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_000916  

REFSEQ mRNAs for OXTR gene: 

NM_000916.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_000916  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000916
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000916
                                 untagged cDNA clone in CMV expression vector: NM_000916 

Additional cDNA sequence: 

AK313830.1 AY389507.1 BC137443.1 X64878.1 

3 DOTS entries:

DT.312426  DT.120880035  DT.120880036 

24/77 AceView cDNA sequences (see all 77 ):

AI952594 AI095416 AI081501 AA599029 AI126365 AI337877 AI424076 BM677838 
AA708935 BF439048 NM_000916 AI373858 AI042536 AW088256 AY389507 BM725410 
AA937742 BX281938 AA770672 AI074793 AI129833 AI147896 AI129228 BG178935 

highest scoring ESTs for OXTR:

CN483273 X64878 AA029292 AA029832 AA043827 AA085759 AA094736 AI050725 AI095591 AI126365 

Unigene Cluster for OXTR:

Oxytocin receptor
Hs.2820  [show with all ESTs]
Unigene Representative Sequence: NM_000916


GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for OXTR (see all 6 )

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6
SP1:              -     -           -                                       
SP2:        -     -     -           -                                       
SP3:                    -           -                                       
SP4:              -     -                                                   
SP5:                                -                                       

About this scheme

ECgene alternative splicing isoforms for OXTR

1 Ensembl transcript including schematic representation:
ENST00000316793  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

OXTR expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for OXTR

1 / 2 / 3

2 probe-sets matching OXTR gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

206825_at2, 3 U133-A 1 1.00 1.00 -- -- NM_000916 0.60 1.00 0.82 1

206825_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: ACTACTAAGG

SOURCE GeneReport for Unigene cluster: Hs.2820
(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for OXTR gene from 5/8 species (see all 8 )
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
OXTR1   -- oxytocin receptor 91.21(n)
93.21(a)
484670  XM_541785.2  XP_541785.2 
chimpanzee
(Pan troglodytes)
OXTR1   -- oxytocin receptor 99.23(n)
98.97(a)
738742  XM_001143957.1  XP_001143957.1 
cow
(Bos taurus)
OXTR1   -- oxytocin receptor 89.09(n)
90.98(a)
281371  NM_174134.2  NP_776559.1 
rat
(Rattus norvegicus)
Oxtr1   -- oxytocin receptor 87.29(n)
91.75(a)
25342  NM_012871.2  NP_037003.2 
mouse
(Mus musculus)
Oxtr1, 5 65
oxytocin receptor1, 5 86.77(n)1
92.27(a)1
184301  NM_001081147.11  NP_001074616.11 
 AK1432875  AK1433405  (see all 8)
About this table        Species with no ortholog for OXTR

ENSEMBL Gene Tree for OXTR
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for OXTR gene
AVPR1A2  AVPR1B2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/178 NCBI SNPs in OXTR are shown (see all 178 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 139)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 3 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs67706321,2
A,C,F,H8768724(+) ctttcC/Aaattt 1 -- ut314Minor allele frequency- A:0.27EU EA WA 402
rs2378841,2
A,C,F,H8768585(+) gtaaaA/Gaagcc 1 -- ut31 ese35Minor allele frequency- G:0.26MN EU EA WA 600
rs10427781,2
A,C,F,H8769545(+) AGGAGG/TGGAGG 1 -- ut31 trp35Minor allele frequency- T:0.38MN EU EA WA 604
rs14884661,2
C,F,H,O8788066(+) TTTCAG/CAGCTC 1 -- ng318Minor allele frequency- C:0.10MN NA EU EA WA 732
rs23247281,2
A,C,F,H8767728(-) agaacG/Aagtgt 1 -- ut317Minor allele frequency- A:0.27EU EA WA NA 562
rs46863021,2
A,C,F,H8784222(+) GCAGGC/TAGCGA 1 A/T mis1 ese34Minor allele frequency- T:0.11EU EA WA 420
rs14653861,2
A,C,F8786653(+) GAGGCG/TTTATT 1 -- ng311Minor allele frequency- T:0.01MN 184
rs98723101,2
C,F,H8768381(+) agtatA/Gagtgt 1 -- ut314Minor allele frequency- G:0.15EU EA WA 418
rs98724251,2
C,F,H8768404(+) tctttA/Tttctg 1 -- ut314Minor allele frequency- T:0.01EU EA WA 412
rs170495281,2
C,F,H8787862(+) GCTTCG/AGCCAG 1 -- ng31 tfbs311Minor allele frequency- A:0.13NA EU EA WA 966
About this table

HapMap Linkage Disequilibrium images for OXTR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 167055

10/25 Novoseek disease relationships for OXTR gene (see all 25 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
dysmenorrhea 52.21 3 15631309 (1), 7978951 (1), 14605818 (1)
preterm delivery 38.56 1 16885542 (1)
autistic 36.93 3 17890818 (1)
chorioamnionitis 21.60 2 11839503 (2)
leiomyoma 15.94 8 9757961 (5), 14576480 (1), 17952758 (1)
von hippel-lindau disease 13.25 1 7573168 (1)
uterine leiomyoma 10.13 1 9757961 (1)
prostate cancer 4.71 4 15375538 (1)
bleeding 4.19 1 9757961 (1)
necrosis 3.76 1 19050328 (1)
About this table

Genetic Association Database: OXTR
Human Genome Epidemiology Navigator: OXTR (12 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/292 PubMed articles for OXTR gene (see all 292 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 5021 HGNC: 8529 AceView: OXTR Ensembl:ENSG00000180914 euGenes: HUgn5021
ECgene: OXTR H-InvDB: OXTR
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

NameDescription
Wikipedia http://en.wikipedia.org/wiki/Oxytocin
(Available from WIS Yeda, Salk, Tufts)
About This Section

  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for OXTR:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for OXTR-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for OXTR Antibodies for OXTR
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for OXTR Small molecules for OXTR
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant & Natural Proteins  

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 Recombinant Proteins
(Oxytocin Receptor)
 Antibodies (Oxytocin Receptor)
 Search OriGene for OXTR
 Tocris compounds for OXTR




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for OXTR

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