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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OXTR Gene

protein-coding GIFtS: 67
GCID: GC03M008767

oxytocin receptor

Explore 43 diseases affiliated with
OXTR via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Oxytocin Receptor¹ ²
OT-R² ³

External Ids:	HGNC: 8529¹	Entrez Gene: 5021²	Ensembl: ENSG00000180914⁷	OMIM: 167055⁵	UniProtKB: P30559³

Export aliases for OXTR gene to outside databases

Previous GC identifer: GC03M008721

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OXTR:

The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin.

Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The

oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559

Function: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a

phosphatidylinositol-calcium second messenger system

summary for OXTR:

Oxytocin receptors (OT) are G-protein-coupled receptors that mediate parturition and lactation. They are

closely related to vasopressin receptors. Oxytocin receptors are coupled to Gq/11 proteins and are localized

to the myoepithelial cells of the mammary gland, and are also expressed in the myometrium and endometrium of

the uterus at the end of pregnancy. Oxytocin receptors are involved in smooth muscle contraction of the

uterus during parturition and facilitate lactation. Oxytocin receptors are also widespread throughout the

central nervous system and modulate a variety of behaviors. These include responses to stress and anxiety,

social memory and recognition, bonding, and sexual and maternal behaviors. The human gene encoding the

oxytocin receptor is localized to chromosome 3p25.

Gene Wiki entry for OXTR (Oxytocin receptor)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OXTR gene promoter:
GR PPAR-gamma1 GR-beta PPAR-gamma2 Nkx2-5 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OXTR promoter sequence

Search SABiosciences Chromatin IP Primers for OXTR

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OXTR

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p25

OXTR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OXTR gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M008767: view genomic region (about GC identifiers)

Start:	8,792,094 bp from pter	End:	8,811,314 bp from pter
Size:	19,221 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559 (See protein sequence)

Recommended Name: Oxytocin receptor

Size: 389 amino acids; 42772 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q15071

Explore the universe of human proteins at neXtProt for OXTR: NX_P30559

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P30559

OXTR Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000907.2

ENSEMBL proteins:

ENSP00000324270 ENSP00000389587 ENSP00000414828

Reactome Protein details: P30559
Human Recombinant Protein Products:

	EMD Millipore Purified and/or Recombinant OXTR Protein
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	Novus Biologicals OXTR Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for OXTR

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	10858434
GO:0005902	microvillus	IEA	--
GO:0005913	cell-cell adherens junction	IEA	--
GO:0016021	integral to membrane	--	--

OXTR for ontologies About GeneDecksing

OXTR Antibody Products:

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Assay Products for OXTR:

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	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for OXTR

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OXTR for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_7TM

IPR002062 Oxytocn_rcpt

IPR000276 GPCR_Rhodpsn

IPR001817 Vasoprsn_rcpt

Graphical View of Domain Structure for InterPro Entry P30559

ProtoNet protein and cluster: P30559

2 Blocks protein families:

IPB001817 Vasopressin receptor signature

IPB002062 Oxytocin receptor signature

UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559

Similarity: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559

Function: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a

phosphatidylinositol-calcium second messenger system

Genatlas biochemistry entry for OXTR:

oxytocin receptor ,G protein coupled receptor superfamily

miRNA Products:		OriGene 3'-UTR Clone: OXTR Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OXTR
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate OXTR:
		hsa-miR-3200-3p hsa-miR-29c hsa-miR-29a hsa-miR-1279 hsa-miR-103a-2* hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: OXTR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OXTR (see all 7) OriGene shRNA RFP: OXTR OriGene siRNA: OXTR
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Gene Editing
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		GenScript: all cDNA clones in your preferred vector: OXTR (NM_000916)
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Cell Line Products:		GenScript OXTR-overexpressing Cell Line for Assay
		Search LifeMap BioReagents cell lines for OXTR

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXTR

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004990	oxytocin receptor activity	IEA	--
GO:0005000	vasopressin receptor activity	IEA	--
GO:0005515	protein binding	--	--
GO:0017046	peptide hormone binding	IEA	--

OXTR for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for OXTR:

Increased gamma-H2AX phosphory

Animal Models:
Mouse knock-outs for OXTR: Oxtr^tm1.2Wsy Oxtr^tm1.1Knis
9 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Oxtr):

behavior/neurological	endocrine/exocrine gland	growth/size	integument	muscle
nervous system	no phenotypic analysis	normal	reproductive system

OXTR for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

Class A/1 (Rhodopsin-like receptors)	1.00	GPCRs, Class A Rhodopsin-like	0.41
GPCR ligand binding	0.75	Neuroactive ligand-receptor interaction	0.38
Peptide ligand-binding receptors	0.61

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

1.00

Peptide GPCRs

0.46

Vasopressin-like receptors

Vasopressin-like receptors

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for OXTR

	Selected targets of C/EBPbeta
	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q

3 BioSystems Pathways for OXTR

	Myometrial Relaxation and Contraction Pathways
	GPCRs, Class A Rhodopsin-like
	Peptide GPCRs

5/9 Reactome Pathways for OXTR (see all 9)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	Vasopressin-like receptors

2 Kegg Pathways (Kegg details for OXTR):

	Calcium signaling pathway
	Neuroactive ligand-receptor interaction

OXTR for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for OXTR

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/130 Interacting proteins for OXTR (P30559³ ENSP00000324270⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 130)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GPRASP1	Q5JY77³, ENSP00000355146⁴	I2D: score=2 STRING: ENSP00000355146
OXT	P01178³, ENSP00000217386⁴	I2D: score=1 STRING: ENSP00000217386
ARRB2	P32121³, ENSP00000269260⁴	I2D: score=1 STRING: ENSP00000269260
AVP	P01185³, ENSP00000369647⁴	I2D: score=1 STRING: ENSP00000369647
GRK5	P34947³, ENSP00000376609⁴	I2D: score=1 STRING: ENSP00000376609

About this table

Gene Ontology (GO): 5/39 biological process terms (GO ID links to tree view) (see all 39): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001967	suckling behavior	IEA	--
GO:0001975	response to amphetamine	IEA	--
GO:0006936	muscle contraction	TAS	1313946
GO:0006950	response to stress	--	--
GO:0007166	cell surface receptor signaling pathway	TAS	1313946

OXTR for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

OXTR for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for OXTR available from Tocris Bioscience About this table

Compound	Action	CAS #
L-368,899 hydrochloride	Potent, non-peptide oxytocin receptor antagonist	[148927-60-0]
Oxytocin	Involved in uterine contraction and lactation	[50-56-6]
WAY 267464 dihydrochloride	Potent non-peptide oxytocin receptor agonist	[847375-16-0]
L-371,257	Potent and selective oxytocin receptor antagonist	[162042-44-6]

3 HMDB Compounds for OXTR About this table

Compound	Synonyms	CAS #	PubMed Ids
Calcium	Ca (see all 2)	7440-70-2	--
Oxytocin	(Arg8)-Vasopressin (see all 22)	50-56-6	--
Vasopressin	3-(Phenylalanine)-8-lysine oxytocin (see all 8)	11000-17-2	--

2 DrugBank Compounds for OXTR About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Oxytocin	Pitocin (see all 2)	50-56-6	target	agonist	15646817 20108008 20104850 18655883 21208749
Carbetocin	Carbetocino [inn-spanish] (see all 2)	37025-55-1	target	agonist	9760035 15740719 11752352

10/62 Novoseek chemical compound relationships for OXTR gene (see all 62) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atosiban	94.8	50	11430968 (3), 15705593 (2), 10191468 (2), 10519430 (2) (see all 32)
ovta	82.3	3	12183418 (2), 15613460 (1)
barusiban	78	6	15740719 (3), 15350251 (1)
carbetocin	77.6	5	15740719 (2), 15017343 (1)
prostaglandin f2alpha	72.6	22	1848585 (1), 8603586 (1), 9675000 (1), 9861156 (1) (see all 16)
13,14-dihydro-15-ketoprostaglandin f2alpha	72.1	2	7616495 (1)
thr(4)-gly(7)-oxytocin	71.2	2	7895660 (1), 8836636 (1)
sr49059	69.7	2	12871758 (1), 15613460 (1)
progesterone	66.1	99	8876043 (6), 12166628 (3), 11101280 (3), 8277221 (3) (see all 39)
ritodrine	63.1	2	10546776 (1), 8671288 (1)

Search CenterWatch for drugs/clinical trials and news about OXTR / OXYR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OXTR gene:

NM_000916.3

Unigene Cluster for OXTR:

Oxytocin receptor

Hs.2820 [show with all ESTs]

Unigene Representative Sequence: NM_000916

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000316793(uc003brc.3) ENST00000449615 ENST00000431493 ENST00000474615

miRNA Products:		OriGene 3'-UTR Clone: OXTR Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OXTR
		6 QIAGEN miScript miRNA Assays for microRNAs that regulate OXTR:
		hsa-miR-3200-3p hsa-miR-29c hsa-miR-29a hsa-miR-1279 hsa-miR-103a-2* hsa-miR-29b
		SwitchGear 3'UTR luciferase reporter plasmid: OXTR 3' UTR sequence

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Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OXTR (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OXTR OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: OXTR (NM_000916)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OXTR

Additional cDNA sequence:

AK313830.1 AY389507.1 BC137443.1 X64878.1

3 DOTS entries:

DT.312426 DT.120880035 DT.120880036

24/77 AceView cDNA sequences (see all 77):

AA708935 AY389507 AA770672 BM725410 AI952594 BM677838 AA599029 BF439048

AI424076 AI095416 AW088256 BX281938 AI373858 AI042536 AA937742 AI126365

AI337877 AI081501 NM_000916 BG121434 AI129833 W49621 AI095591 BG178935

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for OXTR (see all 6) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	^	4a	·	4b	·	4c	·	4d	^	5	^	6
SP1:					-		-				-
SP2:			-		-		-				-
SP3:							-				-
SP4:					-		-
SP5:											-

ECgene alternative splicing isoforms for OXTR

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OXTR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTACTAAGG

About this image

OXTR expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Visceral White Adipose

Visceral White Adipocytes

Adipose

Ovary

Visceral White Adipose

Adipose

Kidney

S-shaped Body

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See OXTR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OXTR

SOURCE GeneReport for Unigene cluster: Hs.2820

SABiosciences Expression via Pathway-Focused PCR Arrays including OXTR:

Neurotransmitter Receptors in human mouse rat

G Protein Coupled Receptors 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXTR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for OXTR gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	OXTR¹	oxytocin receptor	75.75(n) 75.13(a)		429211 NM_001031569.1 NP_001026740.1
lizard (Anolis carolinensis)	Reptilia	D0VFF8_ANOCA⁶	Mesotocin receptor Fragment	72(a)	1 ↔ 1	GL343273.1(1764625-1765104)
zebrafish (Danio rerio)	Actinopterygii	oxtrl¹	oxytocin receptor like	65.38(n) 66.76(a)		796298 NM_001199369.1 NP_001186298.1
worm (Caenorhabditis elegans)	Secernentea	T07D10.2⁶ F14F4.1⁶	Protein F14F4.1	21(a) 18(a)	many ↔ many many ↔ many	I(12621161-12623074) X(14924963-14928864)

ENSEMBL Gene Tree for OXTR (if available)
TreeFam Gene Tree for OXTR (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OXTR gene

GPR150² AVPR1A² AVPR1B² AVPR2² GNRHR² NPSR1² GNRHR2²

5 SIMAP similar genes for OXTR using alignment to 6 protein entries: OXYR_HUMAN (see all proteins):

AVPR1 AVPR1B AVPR1A NPSR1 AVPR2

OXTR for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7355797^1,2	C,H	--	8791829(+)	`CACCTC/TTAGTG`	1	--	ds500¹ ese³		4		NS EA	420
rs59746083^1,2	C,F,	--	8791844(+)	`TCTATT/GTTAAA`	1	--	ds500¹		6		WA NA CSA	246
rs56898713^1,2	C,F,	--	8791883(+)	`CATCAC/TTTGTG`	1	--	ds500¹		6		WA NA CSA	246
rs11718520^1,2	C,H	--	8792276(+)	`ctataT/Cagatt`	1	--	ut3¹ ese³		4		NS EA	414
rs190493540^1,2	C,	--	8792295(+)	`TTAGAC/TATTGC`	1	--	ut3¹		0	--	--	--	--
rs181982781^1,2		--	8792632(+)	`TTTTGA/CGGTAC`	1	--	ut3¹		0	--	--	--	--
rs35014760^1,2	C,F,	--	8792655(+)	`TTTCAA/CAGCAG`	1	--	ut3¹		4		NA WA	242
rs2324728^1,2	C,F,A,H,	--	8792728(-)	`AGAACG/AAGTGT`	1	--	ut3¹		23		NS EA NA WA CSA	2284
rs143101393^1,2	C,	--	8792818(+)	`AATAAC/TAATGT`	1	--	ut3¹		0	--	--	--	--
rs4493422^1,2	C,F,	--	8792846(+)	`GCTTAG/TTAGCC`	1	--	ut3¹		8		NA WA CSA	250

HapMap Linkage Disequilibrium report for OXTR (8792094 - 8811314 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for OXTR
2 CNVs: 51179 59151
Human Gene Mutation Database (HGMD): OXTR

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OXTR for disorders           About GeneDecksing

OMIM gene information: 167055    OMIM disorders: --

20/43 diseases for OXTR (see all 43):    About MalaCards

von hippel-lindau disease tricuspid valve stenosis patent ductus arteriosus nephrogenic diabetes insipidus

social cognition smooth muscle tumor diabetes insipidus autism spectrum disorder

hypotropia endometrial stromal sarcoma atypical autism chorioamnionitis

autistic disorder male infertility leiomyoma myoma

small cell carcinoma mood disorder kaposi's sarcoma endometrial carcinoma

2 diseases from the University of Copenhagen DISEASES database for OXTR:

Autistic disorder Tricuspid valve stenosis

10/25 Novoseek disease relationships for OXTR gene (see all 25) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
dysmenorrhea	53	7	20096818 (3), 15631309 (1), 7978951 (1), 14605818 (1)
autistic	41.2	9	19777562 (2), 20347913 (1), 17890818 (1)
preterm delivery	36.7	1	16885542 (1)
chorioamnionitis	19.8	2	11839503 (2)
leiomyoma	14	8	9757961 (5), 14576480 (1), 17952758 (1)
von hippel-lindau disease	11.4	1	7573168 (1)
uterine leiomyoma	7.97	1	9757961 (1)
prostate cancer	4.3	4	15375538 (1)
bleeding	3.77	1	9757961 (1)
necrosis	3.46	1	19050328 (1)

Genetic Association Database (GAD): OXTR
Human Genome Epidemiology (HuGE) Navigator: OXTR (35 documents)

Export disorders for OXTR gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OXTR gene, integrated from 9 sources (see all 399):
(articles sorted by number of sources associating them with OXTR)

Utopia: connect your pdf to the dynamic
world of online information

Structure and expression of a human oxytocin receptor. (PubMed id 1313946)^{1, 2, 3, 9} Kimura T.... Okayama H. (1992)
Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. (PubMed id 15992526)^{1, 4, 9} Wu S....Zhang D. (2005)
Variant in oxytocin receptor gene is associated with amygdala volume. (PubMed id 21208749)^{1, 7} Furman D.J....Gotlib I.H. (2011)
Structural organization of the human oxytocin receptor gene. (PubMed id 7798245)^{1, 2} Inoue T.... Saji F. (1994)
Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin. (PubMed id 15740719)^{7, 9} Gimpl G....Reinheimer T. (2005)
Amino acids in the COOH-terminal region of the oxytocin receptor third intracellular domain are important for receptor function. (PubMed id 17148753)^{1, 9} Zhong M....Sanborn B.M. (2007)
Oxytocin receptor expression in smooth muscle cells of peritoneal endometriotic lesions and ovarian endometriotic cysts. (PubMed id 15831296)^{1, 9} Mechsner S....Ebert A.D. (2005)
Identification of dimeric and oligomeric complexes of the human oxytocin receptor by co-immunoprecipitation and bioluminescence resonance energy transfer. (PubMed id 14664707)^{1, 9} Devost D. and Zingg H.H. (2003)
Regulation of oxytocin receptor responsiveness by G p rotein-coupled receptor kinase 6 in human myometrial smooth muscle. (PubMed id 19423652)^{1, 9} Willets J.M....Challiss R.A. (2009)
Colocalization of androgen binding protein, oxytocin receptor, caveolin 1 and proliferation marker p21 in benign prostate hyperplasia. (PubMed id 18312604)^{1, 9} Sendemir E....Jirikowski G.F. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5021	HGNC: 8529	AceView: OXTR	Ensembl:ENSG00000180914	euGenes: HUgn5021
ECgene: OXTR	Kegg: 5021	H-InvDB: OXTR

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OXTR	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Oxytocin

Intellectual Property for OXTR gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for OXTR gene:
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GeneCards and IP:
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oxytocin receptor

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