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Aliases & Descriptions for OXTR
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| oxytocin receptor 2 |
|
| | Search outside databases for aliases for OXTR genePrevious GC identifer: GC03M008721 |
Summaries for OXTR(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for OXTR: The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq] UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559Function: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger systemGene Wiki entry for OXTR (Oxytocin_receptor) |
Genomic Location for OXTR
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the OXTR gene 
Entrez Gene cytogenetic band: 3p25 Ensembl cytogenetic band: 3p25.3 HGNC cytogenetic band: 3p25OXTR Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M008767:
(about GC identifiers)
Start:
|
8,767,094 bp from pter |
End:
|
8,786,300 bp from pter |
Size:
|
19,207 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000003.10 NT_022517.17
| Proteins for OXTR
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559 (See
protein sequence)Recommended Name: Oxytocin receptor Size: 389 amino acids; 42772 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q15071REFSEQ proteins: NP_000907.2
ENSEMBL proteins: ENSP00000324270
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for OXTR: Assays for OXTR: | Protein
Domains/ Families for OXTR(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P30559
ProtoNet protein and cluster: P30559 2 Blocks protein families: IPB001817 Vasopressin receptor signature IPB002062 Oxytocin receptor signature
UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559Similarity: Belongs to the G-protein coupled receptor 1 family | Gene Function for OXTR
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000916
Applied Biosystems Silencer® siRNAs for OXTR
Sigma-Aldrich siRNA and siRNA Panels for OXTR  Sigma-Aldrich shRNA Panels and shRNA for OXTR  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000916                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000916                                  untagged cDNA clone in CMV expression vector: NM_000916 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000916
UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559Function: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger systemGenatlas biochemistry entry for OXTR:oxytocin receptor ,G protein coupled receptor superfamily9 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Oxtr):
5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for OXTR
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for OXTR 
5/15 Interacting proteins for OXTR (ENSP000003242703) via UniProtKB, MINT, and/or STRING (see all 15
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for OXTR(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for OXTR available from Tocris Bioscience 10/33 Novoseek chemical compound relationships for OXTR gene (see all 33
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| ovta |
82.70 |
3 |
12183418 (2), 15613460 (1) |
| carbetocin |
80.21 |
5 |
15740719 (2), 15017343 (1) |
| barusiban |
79.68 |
6 |
15740719 (3), 15350251 (1) |
| 13,14-dihydro-15-ketoprostaglandin f2alpha |
72.84 |
2 |
7616495 (1) |
| thr(4)-gly(7)-oxytocin |
71.69 |
2 |
7895660 (1), 8836636 (1) |
| progesterone |
66.74 |
95 |
8876043 (6), 12166628 (3), 11101280 (3), 8277221 (3) (see all 38) |
| prostaglandin |
62.07 |
18 |
11241181 (3), 19050328 (2), 14973258 (2), 11101280 (2) (see all 12) |
| chapso |
57.68 |
1 |
10785367 (1) |
| steroid |
45.35 |
21 |
8776795 (2), 8396613 (2), 12436925 (2), 9548257 (2) (see all 14) |
| (+-)-pgf2-alpha |
41.36 |
5 |
17205424 (1), 9675000 (1), 17459165 (1) |
About this table
1 PharmGKB drug compound relationship for OXTR gene
| Drug compound |
PharmGKB Relations |
PubMed IDs for articles supporting these relationships |
| doxorubicin | FA   | 11313874 | About this table
|
Transcripts for OXTR(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000916
Sigma-Aldrich siRNA and siRNA Panels for OXTR  Sigma-Aldrich shRNA Panels and shRNA for OXTR  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000916 REFSEQ mRNAs for OXTR gene: NM_000916.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000916               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000916                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000916                                  untagged cDNA clone in CMV expression vector: NM_000916  Additional cDNA sequence: AK313830.1 AY389507.1 BC137443.1 X64878.1 3 DOTS entries: DT.312426 DT.120880035 DT.120880036 24/77 AceView cDNA sequences (see all 77
):AI952594 AI095416 AI081501 AA599029 AI126365 AI337877 AI424076 BM677838 AA708935 BF439048 NM_000916 AI373858 AI042536 AW088256 AY389507 BM725410 AA937742 BX281938 AA770672 AI074793 AI129833 AI147896 AI129228 BG178935
highest scoring ESTs for OXTR:CN483273 X64878 AA029292 AA029832 AA043827 AA085759 AA094736 AI050725 AI095591 AI126365 Unigene Cluster for OXTR: Oxytocin receptor Hs.2820 [show with all ESTs]Unigene Representative Sequence: NM_000916
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for OXTR (see all 6
)
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | |
| SP1: | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | - |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for OXTR
1 Ensembl transcript including schematic representation: ENST00000316793
|
Expression for OXTR
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| OXTR expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for OXTR
1 / 2 / 3 2 probe-sets matching OXTR gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: ACTACTAAGG
SOURCE GeneReport for Unigene cluster: Hs.2820
|
Orthologs for OXTR
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for OXTR gene from 5/8 species (see all 8
)
About this table Species with no ortholog for OXTR
ENSEMBL Gene Tree for OXTR | Paralogs for OXTR(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for OXTR gene
- AVPR1A2 AVPR1B2
|
SNPs/Variants for OXTR(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for OXTR (up to first 250kb)
|
Disorders & Mutations for OXTR
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 167055
10/25 Novoseek disease relationships for OXTR gene (see all 25
)
About this table
Genetic Association Database: OXTR Human Genome Epidemiology Navigator: OXTR (12 documents)
|
Medical News for OXTR(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for OXTR (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/292 PubMed articles for OXTR gene (see all 292
):- Structure and expression of a human oxytocin receptor. (PubMed id 1313946)1, 2, 3, 4 Kimura T.... Okayama H. (1992)
- Positive association of the oxytocin receptor gene (OXTR) with autism in the Chinese Han population. (PubMed id 15992526)1, 3, 6 Wu S....Zhang D. (2005)
- Structural organization of the human oxytocin receptor gene. (PubMed id 7798245)3, 4 Inoue T.... Saji F. (1994)
- Amino acids in the COOH-terminal region of the oxytocin receptor third intracellular domain are important for receptor function. (PubMed id 17148753)1, 3 Zhong M....Sanborn B.M. (2007)
- Oxytocin receptor expression in smooth muscle cells of peritoneal endometriotic lesions and ovarian endometriotic cysts. (PubMed id 15831296)1, 3 Mechsner S....Ebert A.D. (2005)
- Identification of dimeric and oligomeric complexes of the human oxytocin receptor by co-immunoprecipitation and bioluminescence resonance energy transfer. (PubMed id 14664707)1, 3 Devost D. and Zingg H.H. (2003)
- Colocalization of androgen binding protein, oxytocin receptor, caveolin 1 and proliferation marker p21 in benign prostate hyperplasia. (PubMed id 18312604)1, 3 Sendemir E....Jirikowski G.F. (2008)
- Expression of sex hormone-binding globulin, oxytocin receptor, caveolin-1 and p21 in leiomyoma. (PubMed id 17952758)1, 3 Sendemir A....Jirikowski G.F. (2008)
- Identification, characterization and biological activity of oxytocin receptor in the developing human penis. (PubMed id 15591449)1, 3 Vignozzi L....Maggi M. (2005)
- Agonist-specific, high-affinity binding epitopes are contributed by an arginine in the N-terminus of the human oxytocin receptor. (PubMed id 11955056)1, 3 Wesley V.J....Wheatley M. (2002)
|
Search for OXTR
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing OXTR
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing OXTR
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OXTR(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Oxytocin |
|
| | | About This Section
| --
| Services for OXTR(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for OXTR:

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| | | | Tocris compounds for OXTR |
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Incremental update: 13 Oct 2009
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