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OXTR Gene

protein-coding   GIFtS: 69
GCID: GC03M008767

Oxytocin Receptor

  See OXTR-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oxytocin Receptor1 2
OT-R2 3

External Ids:    HGNC: 85291   Entrez Gene: 50212   Ensembl: ENSG000001809147   OMIM: 1670555   UniProtKB: P305593   

Export aliases for OXTR gene to outside databases

Previous GC identifer: GC03M008721


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OXTR Gene:
The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for
oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger
system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. (provided
by RefSeq, Jul 2008)

GeneCards Summary for OXTR Gene:
OXTR (oxytocin receptor) is a protein-coding gene. Diseases associated with OXTR include atypical autism, and adenomyosis. GO annotations related to this gene include oxytocin receptor activity and peptide hormone binding. An important paralog of this gene is GPR150.

UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559
Function: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a
phosphatidylinositol-calcium second messenger system

summary for OXTR Gene:
Oxytocin receptors (OT) are G-protein-coupled receptors that mediate parturition and lactation. They are
closely related to vasopressin receptors. Oxytocin receptors are coupled to Gq/11 proteins and are localized
to the myoepithelial cells of the mammary gland, and are also expressed in the myometrium and endometrium of
the uterus at the end of pregnancy. Oxytocin receptors are involved in smooth muscle contraction of the
uterus during parturition and facilitate lactation. Oxytocin receptors are also widespread throughout the
central nervous system and modulate a variety of behaviors. These include responses to stress and anxiety,
social memory and recognition, bonding, and sexual and maternal behaviors. The human gene encoding the
oxytocin receptor is localized to chromosome 3p25.

Gene Wiki entry for OXTR (Oxytocin receptor) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the OXTR gene promoter:
         GR   PPAR-gamma1   GR-beta   PPAR-gamma2   Nkx2-5   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOXTR promoter sequence
   Search Chromatin IP Primers for OXTR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OXTR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p25   Ensembl cytogenetic band:  3p25.3   HGNC cytogenetic band: 3p25

OXTR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OXTR gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M008767:  view genomic region     (about GC identifiers)

Start:
8,792,094 bp from pter      End:
8,811,314 bp from pter
Size:
19,221 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559 (See protein sequence)
Recommended Name: Oxytocin receptor  
Size: 389 amino acids; 42772 Da
Secondary accessions: Q15071

Explore the universe of human proteins at neXtProt for OXTR: NX_P30559

Explore proteomics data for OXTR at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn8, Asn15, Asn26
  • Modification sites at PhosphoSitePlus

  • See OXTR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000907.2  
    ENSEMBL proteins: 
     ENSP00000324270   ENSP00000389587   ENSP00000414828  
    Reactome Protein details: P30559

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    Search eBioscience for ELISAs for OXTR 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AVPR: GPCR / Class A : Vasopressin and oxytocin receptors

    IUPHAR Guide to PHARMACOLOGY protein family classification: OT receptor
    Vasopressin and oxytocin receptors

    4 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR002062 Oxytocn_rcpt
     IPR000276 GPCR_Rhodpsn
     IPR001817 Vasoprsn_rcpt

    Graphical View of Domain Structure for InterPro Entry P30559

    ProtoNet protein and cluster: P30559

    2 Blocks protein domains:
    IPB001817 Vasopressin receptor signature
    IPB002062 Oxytocin receptor signature


    UniProtKB/Swiss-Prot: OXYR_HUMAN, P30559
    Similarity: Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily


    Find genes that share domains with OXTR           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OXYR_HUMAN, P30559
    Function: Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a
    phosphatidylinositol-calcium second messenger system

         Genatlas biochemistry entry for OXTR:
    oxytocin receptor ,G protein coupled receptor superfamily

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
    GO:0004990oxytocin receptor activity IEA--
    GO:0005000vasopressin receptor activity IEA--
    GO:0005515protein binding ----
    GO:0017046peptide hormone binding IEA--
         
    Find genes that share ontologies with OXTR           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for OXTR:
     Increased gamma-H2AX phosphory 

         9 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Oxtr):
     behavior/neurological  endocrine/exocrine gland  growth/size/body  integument  muscle 
     nervous system  no phenotypic analysis  normal  reproductive system 

    Find genes that share phenotypes with OXTR           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for OXTR: Oxtrtm1.2Wsy Oxtrtm1.1Knis

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OXTR
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OXTR

    miRNA
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    miRTarBase miRNAs that target OXTR:
    hsa-mir-1 (MIRT023713)

    Block miRNA regulation of human, mouse, rat OXTR using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate OXTR:
    hsa-miR-3200-3p hsa-miR-29c hsa-miR-29a hsa-miR-1279 hsa-miR-103a-2* hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidOXTR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OXTR

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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OXTR (NM_000916)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OXTR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXTR

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXTR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OXYR_HUMAN, P30559: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    nucleus2
    cytoskeleton1
    extracellular1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane TAS10858434
    GO:0005902microvillus IEA--
    GO:0005913cell-cell adherens junction IEA--
    GO:0016021integral component of membrane ----

    Find genes that share ontologies with OXTR           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for OXTR About   (see all 8)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    GPCRs, Class A Rhodopsin-like0.43
    GPCR ligand binding0.71
    Neuroactive ligand-receptor interaction0.36
    Peptide ligand-binding receptors0.60
    Vasopressin-like receptors0.00
    2Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    Neuropeptides signaling through G protein alpha i and G protein alpha q0.46
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    5Myometrial Relaxation and Contraction Pathways
    Myometrial Relaxation and Contraction Pathways0.43


    Find genes that share SuperPaths with OXTR           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for OXTR
        Myometrial Relaxation and Contraction Pathways
    GPCRs, Class A Rhodopsin-like
    Peptide GPCRs

    2 Reactome Pathways for OXTR
        G alpha (q) signalling events
    Vasopressin-like receptors


    3 Kegg Pathways  (Kegg details for OXTR):
        Calcium signaling pathway
    Neuroactive ligand-receptor interaction
    Oxytocin signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Arrays including OXTR: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for OXTR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OXTR (P305593 ENSP000003242704) via UniProtKB, MINT, STRING, and/or I2D (see all 137)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GPRASP1Q5JY773, ENSP000003551464I2D: score=2 STRING: ENSP00000355146
    OXTP011783, ENSP000002173864I2D: score=1 STRING: ENSP00000217386
    ARRB2P321213, ENSP000002692604I2D: score=1 STRING: ENSP00000269260
    AVPP011853, ENSP000003696474I2D: score=1 STRING: ENSP00000369647
    GRK5P349473, ENSP000003766094I2D: score=1 STRING: ENSP00000376609
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001967suckling behavior IEA--
    GO:0001975response to amphetamine IEA--
    GO:0006936muscle contraction TAS1313946
    GO:0007166cell surface receptor signaling pathway TAS1313946
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with OXTR           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for OXTR available from Tocris Bioscience    About this table
    CompoundAction CAS #
    OxytocinInvolved in uterine contraction and lactation[50-56-6]
    L-368,899 hydrochloride Potent, non-peptide oxytocin receptor antagonist [148927-60-0]
    WAY 267464 dihydrochloridePotent non-peptide oxytocin receptor agonist[847375-16-0]
    CarbetocinOxytocin analog[37025-55-1]
    L-371,257 Potent and selective oxytocin receptor antagonist[162042-44-6]

    3 HMDB Compounds for OXTR    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    Oxytocin(Arg8)-Vasopressin (see all 22)50-56-6--
    Vasopressin3-(Phenylalanine)-8-lysine oxytocin (see all 8)11000-17-2--

    2 DrugBank Compounds for OXTR    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    OxytocinPitocin (see all 2)50-56-6targetagonist15646817 20108008 20104850 18655883 21208749
    CarbetocinCarbetocino [inn-spanish] (see all 2)37025-55-1targetagonist9760035 15740719 11752352

    Selected IUPHAR Ligands for OXTR (OT receptor) (see all 44)    About this table
    LigandTypeActionAffinityPubmed IDs
    [35S]non-peptide OT antagonist
    AntagonistAntagonist10.3812176104
    [125I]d(CH2)5[Tyr(Me)2,Thr4,Orn8,Tyr-NH29]OVT
    AntagonistAntagonist10--
    d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT
    AntagonistAntagonist9.2 - 1015880385 16158071
    d(CH2)5[Tyr(Me)2,Thr4,Tyr(3125I)-NH29]OVT
    AntagonistAntagonist9.7 - 1011337500 7774575 8955347
    oxytocin
    AgonistFull agonist8.2 - 9.67774575 16158071 12660315 8955347 7475979 10519430
    d(CH2)5[Tyr(Me)2,Thr4,Phe(3125I,4N3)-NH29]OVT
    AntagonistAntagonist9.611337500
    [3H]OT (human, mouse, rat)
    AgonistFull agonist8.2 - 9.57921228 7774575 6278592 7475979
    L-366,875
    AntagonistAntagonist9.57475979
    AVT
    AgonistFull agonist9.47774575 8955347
    vasopressin
    AgonistPartial agonist7.3 - 9.312446593 7774575 16158071 7475979 10519430 15084136 8955347 11337500

    Selected Novoseek inferred chemical compound relationships for OXTR gene (see all 62)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atosiban 94.8 50 11430968 (3), 15705593 (2), 10191468 (2), 10519430 (2) (see all 32)
    ovta 82.3 3 12183418 (2), 15613460 (1)
    barusiban 78 6 15740719 (3), 15350251 (1)
    carbetocin 77.6 5 15740719 (2), 15017343 (1)
    prostaglandin f2alpha 72.6 22 1848585 (1), 8603586 (1), 9675000 (1), 9861156 (1) (see all 16)
    13,14-dihydro-15-ketoprostaglandin f2alpha 72.1 2 7616495 (1)
    thr(4)-gly(7)-oxytocin 71.2 2 7895660 (1), 8836636 (1)
    sr49059 69.7 2 12871758 (1), 15613460 (1)
    progesterone 66.1 99 8876043 (6), 12166628 (3), 11101280 (3), 8277221 (3) (see all 39)
    ritodrine 63.1 2 10546776 (1), 8671288 (1)



    Find genes that share compounds with OXTR           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OXTR gene: 
    NM_000916.3  

    Unigene Cluster for OXTR:

    Oxytocin receptor
    Hs.2820  [show with all ESTs]
    Unigene Representative Sequence: NM_000916
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000316793(uc003brc.3) ENST00000449615 ENST00000431493 ENST00000474615

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate OXTR:
    hsa-miR-3200-3p hsa-miR-29c hsa-miR-29a hsa-miR-1279 hsa-miR-103a-2* hsa-miR-29b
    SwitchGear 3'UTR luciferase reporter plasmidOXTR 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat OXTR
    Clone
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    OriGene clones in human, mouse for OXTR (see all 6)
    OriGene ORF clones in mouse, rat for OXTR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OXTR (NM_000916)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OXTR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXTR
    Primer
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    OriGene qPCR primer pairs and template standards for OXTR
    OriGene qSTAR qPCR primer pairs in human, mouse for OXTR
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      QuantiTect SYBR Green Assays in human, mouse, rat OXTR
      QuantiFast Probe-based Assays in human, mouse, rat OXTR

    Additional mRNA sequence: 

    AK313830.1 AY389507.1 BC137443.1 X64878.1 

    3 DOTS entries:

    DT.312426  DT.120880035  DT.120880036 

    Selected AceView cDNA sequences (see all 77):

    AI424076 AA937742 BM725410 AA708935 AI081501 NM_000916 BM677838 BF439048 
    AW088256 AI952594 AA599029 AI373858 AI126365 AY389507 BX281938 AI095416 
    AI337877 AI042536 AA770672 W49719 BG251303 BU935285 AW244068 AI129228 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OXTR (see all 6)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6
    SP1:              -     -           -                                       
    SP2:        -     -     -           -                                       
    SP3:                    -           -                                       
    SP4:              -     -                                                   
    SP5:                                -                                       


    ECgene alternative splicing isoforms for OXTR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    OXTR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTACTAAGG
    OXTR Expression
    About this image


    OXTR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 2 entries
             Umbilical cord blood-derived mesenchymal stem cells
     
     Mesenchymal Stem Cells (Uncategorized)    fully expand to see all 2 entries
             Umbilical cord-derived mesenchymal stem cells (family)
     
     Eye (Sensory Organs)
             nGnG Amacrine Cells Inner Nuclear Layer
     
     Ovary (Reproductive System)
             Granulosa Cells Primary Follicle
    OXTR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OXTR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.2820
        Pathway & Disease-focused RT2 Profiler PCR Arrays including OXTR: 
              Neurotransmitter Receptors in human mouse rat
              G Protein Coupled Receptors 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OXTR gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oxtr1 , 5 oxytocin receptor1, 5 87.01(n)1
    92.2(a)1
      6 (52.27 cM)5
    184301  NM_001081147.11  NP_001074616.11 
     1124736845 
    chicken
    (Gallus gallus)
    Aves OXTR1 oxytocin receptor 77.91(n)
    77.91(a)
      429211  NM_001031569.1  NP_001026740.1 
    lizard
    (Anolis carolinensis)
    Reptilia OXTR6
    oxytocin receptor
    70(a)
    1 ↔ 1
    GL343273.1(1763300-1784557)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004938761 mesotocin receptor-like 70.22(n)
    71.95(a)
      100493876  XM_002936251.2  XP_002936297.1 
    zebrafish
    (Danio rerio)
    Actinopterygii oxtrl1 oxytocin receptor like 68.1(n)
    70.77(a)
      796298  NM_001199369.1  NP_001186298.1 


    ENSEMBL Gene Tree for OXTR (if available)
    TreeFam Gene Tree for OXTR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OXTR gene
    GPR1502  AVPR1A2  AVPR22  AVPR1B2  GNRHR2  NPSR12  
    5 SIMAP similar genes for OXTR using alignment to 6 protein entries:     OXYR_HUMAN (see all proteins):
    AVPR1    AVPR1B    AVPR1A    NPSR1    AVPR2

    Find genes that share paralogs with OXTR           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OXTR (see all 799)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs73557971,2
    C,H--8791829(+) CACCTC/TTAGTG 1 -- ds5001 ese34Minor allele frequency- T:0.00NS EA 420
    rs597460831,2
    C,F--8791844(+) TCTATT/GTTAAA 1 -- ds50016Minor allele frequency- G:0.26WA NA CSA 246
    rs568987131,2
    C,F--8791883(+) CATCAC/TTTGTG 1 -- ds50016Minor allele frequency- T:0.23WA NA CSA 246
    rs117185201,2
    C,H--8792276(+) ctataT/Cagatt 1 -- ut31 ese34Minor allele frequency- C:0.00NS EA 414
    rs1904935401,2
    C--8792295(+) TTAGAC/TATTGC 1 -- ut310--------
    rs1819827811,2
    --8792632(+) TTTTGA/CGGTAC 1 -- ut310--------
    rs350147601,2
    C,F--8792655(+) TTTCAA/CAGCAG 1 -- ut314Minor allele frequency- C:0.17NA WA 242
    rs23247281,2
    C,F,A,H--8792728(-) agaacG/Aagtgt 1 -- ut3123Minor allele frequency- A:0.29NS EA NA WA CSA 2284
    rs1431013931,2
    C--8792818(+) AATAAC/TAATGT 1 -- ut310--------
    rs44934221,2
    C,F--8792846(+) gcttaG/Ttagcc 1 -- ut318Minor allele frequency- T:0.36NA WA CSA 250

    HapMap Linkage Disequilibrium report for OXTR (8792094 - 8811314 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for OXTR:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv5104n71CNV Loss21882294
    nsv516057CNV Loss19592680
    nsv819115CNV Gain19587683
    nsv876514CNV Gain21882294

    Human Gene Mutation Database (HGMD): OXTR
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 167055    OMIM disorders: --

    4 diseases for OXTR:    
    About MalaCards
    atypical autism    adenomyosis    chorioamnionitis    leiomyoma

    2 diseases from the University of Copenhagen DISEASES database for OXTR:
    Autistic disorder     Atypical autism

    Find genes that share disorders with OXTR           About GenesLikeMe

    Selected Novoseek inferred disease relationships for OXTR gene (see all 25)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dysmenorrhea 53 7 20096818 (3), 15631309 (1), 7978951 (1), 14605818 (1)
    autistic 41.2 9 19777562 (2), 20347913 (1), 17890818 (1)
    preterm delivery 36.7 1 16885542 (1)
    chorioamnionitis 19.8 2 11839503 (2)
    leiomyoma 14 8 9757961 (5), 14576480 (1), 17952758 (1)
    von hippel-lindau disease 11.4 1 7573168 (1)
    uterine leiomyoma 7.97 1 9757961 (1)
    prostate cancer 4.3 4 15375538 (1)
    bleeding 3.77 1 9757961 (1)
    necrosis 3.46 1 19050328 (1)

    Genetic Association Database (GAD): OXTR
    Human Genome Epidemiology (HuGE) Navigator: OXTR (35 documents)

    Export disorders for OXTR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OXTR gene, integrated from 10 sources (see all 421):
    (articles sorted by number of sources associating them with OXTR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structure and expression of a human oxytocin receptor. (PubMed id 1313946)1, 2, 3, 9 Kimura T.... Okayama H. (Nature 1992)
    2. Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population. (PubMed id 20094064)1, 4, 9 Liu X....Sasaki T. (J. Hum. Genet. 2010)
    3. Oxytocin receptor (OXTR) does not play a major role in the aetiology of autism: genetic and molecular studies. (PubMed id 20303388)1, 4, 9 Tansey K.E....Anney R.J. (Neurosci. Lett. 2010)
    4. Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. (PubMed id 17893705)1, 4, 9 Lerer E....Ebstein R.P. (Mol. Psychiatry 2008)
    5. Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms. (PubMed id 19943975)1, 4, 9 Truedsson M....Ohlsson B. (BMC Gastroenterol 2009)
    6. The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. (PubMed id 19461999)1, 4, 9 Israel S....Ebstein R.P. (PLoS ONE 2009)
    7. Oxytocin receptor (OXTR) and serotonin transporter (5-HTT) genes associated with observed parenting. (PubMed id 19015103)1, 4, 9 Bakermans-Kranenburg M.J. and van Ijzendoorn M.H. (Soc Cogn Affect Neurosci 2008)
    8. Association of the oxytocin receptor gene (OXTR) in Caucasian children and adolescents with autism. (PubMed id 17383819)1, 4, 9 Jacob S....Cook E.H. (Neurosci. Lett. 2007)
    9. Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning level. (PubMed id 19777562)1, 4, 9 Wermter A.K....Remschmidt H. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    10. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. (PubMed id 19934046)1, 4, 9 Rodrigues S.M....Keltner D. (Proc. Natl. Acad. Sci. U.S.A. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5021 HGNC: 8529 AceView: OXTR Ensembl:ENSG00000180914 euGenes: HUgn5021
    ECgene: OXTR Kegg: 5021 H-InvDB: OXTR

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for OXTR Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Oxytocin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for OXTR gene:
    Search GeneIP for patents involving OXTR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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