Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OXTR Gene

Aliases for OXTR Gene

  • Oxytocin Receptor 2 3
  • OT-R 3 4

External Ids for OXTR Gene

Previous GeneCards Identifiers for OXTR Gene

  • GC03M008721

Summaries for OXTR Gene

Entrez Gene Summary for OXTR Gene

  • The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition. [provided by RefSeq, Jul 2008]

GeneCards Summary for OXTR Gene

OXTR (Oxytocin Receptor) is a Protein Coding gene. Diseases associated with OXTR include atypical autism and adenomyosis. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include peptide hormone binding and oxytocin receptor activity. An important paralog of this gene is AVPR1B.

UniProtKB/Swiss-Prot for OXTR Gene

  • Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system

Tocris Summary for OXTR Gene

  • Oxytocin receptors (OT) are G-protein-coupled receptors that mediate parturition and lactation. They are closely related to vasopressin receptors. Oxytocin receptors are coupled to Gq/11 proteins and are localized to the myoepithelial cells of the mammary gland, and are also expressed in the myometrium and endometrium of the uterus at the end of pregnancy. Oxytocin receptors are involved in smooth muscle contraction of the uterus during parturition and facilitate lactation. Oxytocin receptors are also widespread throughout the central nervous system and modulate a variety of behaviors. These include responses to stress and anxiety, social memory and recognition, bonding, and sexual and maternal behaviors. The human gene encoding the oxytocin receptor is localized to chromosome 3p25.

Gene Wiki entry for OXTR Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXTR Gene

Genomics for OXTR Gene

Regulatory Elements for OXTR Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OXTR Gene

8,750,408 bp from pter
8,769,628 bp from pter
19,221 bases
Minus strand

Genomic View for OXTR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OXTR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXTR Gene

Proteins for OXTR Gene

  • Protein details for OXTR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Oxytocin receptor
    Protein Accession:
    Secondary Accessions:
    • Q15071

    Protein attributes for OXTR Gene

    389 amino acids
    Molecular mass:
    42772 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OXTR Gene

Proteomics data for OXTR Gene at MOPED

Post-translational modifications for OXTR Gene

  • Glycosylation at Asn8, Asn15, and Asn26
  • Modification sites at PhosphoSitePlus

Other Protein References for OXTR Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for OXTR Gene

Domains for OXTR Gene

Gene Families for OXTR Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
  • Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.
genes like me logo Genes that share domains with OXTR: view

Function for OXTR Gene

Molecular function for OXTR Gene

GENATLAS Biochemistry:
oxytocin receptor ,G protein coupled receptor superfamily
UniProtKB/Swiss-Prot Function:
Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system

Gene Ontology (GO) - Molecular Function for OXTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
GO:0004990 oxytocin receptor activity IEA --
GO:0005000 vasopressin receptor activity IBA --
GO:0005515 protein binding --
GO:0017046 peptide hormone binding IEA --
genes like me logo Genes that share ontologies with OXTR: view
genes like me logo Genes that share phenotypes with OXTR: view

Animal Models for OXTR Gene

MGI Knock Outs for OXTR:

miRNA for OXTR Gene

miRTarBase miRNAs that target OXTR

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OXTR

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for OXTR Gene

Localization for OXTR Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXTR Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OXTR Gene COMPARTMENTS Subcellular localization image for OXTR gene
Compartment Confidence
plasma membrane 5
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for OXTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 10858434
GO:0005902 microvillus IEA --
GO:0005913 cell-cell adherens junction IEA --
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with OXTR: view

Pathways for OXTR Gene

genes like me logo Genes that share pathways with OXTR: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for OXTR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001967 suckling behavior IEA --
GO:0001975 response to amphetamine IEA --
GO:0001992 regulation of systemic arterial blood pressure by vasopressin IBA --
GO:0006936 muscle contraction TAS 1313946
GO:0007166 cell surface receptor signaling pathway TAS 1313946
genes like me logo Genes that share ontologies with OXTR: view

Drugs for OXTR Gene

(2) Drugbank Compounds for OXTR Gene

Compound Status Synonyms Cas Number PubChem ID Type Actions PubMed IDs
  • 1-Butanoic acid-2-(O-methyl-L-tyrosine)-1-carbaoxytocin
37025-55-1 Target agonist approved
  • Pitocin
50-56-6 Target agonist approved

(5) Tocris Compounds for OXTR Gene

Compound Action Cas Number
Carbetocin Oxytocin analog [37025-55-1]
L-368,899 hydrochloride Potent, non-peptide oxytocin receptor antagonist [160312-62-9]
L-371,257 Potent and selective oxytocin receptor antagonist [162042-44-6]
Oxytocin Involved in uterine contraction and lactation [50-56-6]
WAY 267464 dihydrochloride Potent non-peptide oxytocin receptor agonist [1432043-31-6]

(4) HMDB Compounds for OXTR Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
  • Carbetocino [inn-spanish]
  • (Arg8)-Vasopressin
  • 3-(Phenylalanine)-8-lysine oxytocin

(44) IUPHAR Ligand for OXTR Gene

Ligand Type Action Affinity Pubmed IDs
[35S]non-peptide OT antagonist Antagonist Antagonist 10.38
[125I]d(CH2)5[Tyr(Me)2,Thr4,Orn8,Tyr-NH29]OVT Antagonist Antagonist 10
d(CH2)5[Tyr(Me)2,Thr4,Tyr-NH29]OVT Antagonist Antagonist 10
d(CH2)5[Tyr(Me)2,Thr4,Tyr(3125I)-NH29]OVT Antagonist Antagonist 10
oxytocin Agonist Full agonist 9.6
d(CH2)5[Tyr(Me)2,Thr4,Phe(3125I,4N3)-NH29]OVT Antagonist Antagonist 9.6
[3H]OT (human, mouse, rat) Agonist Full agonist 9.5
L-366,875 Antagonist Antagonist 9.5
AVT Agonist Full agonist 9.4
vasopressin Agonist Partial agonist 9.3
L023103 Antagonist Antagonist 9.2
SSR126768A Antagonist Antagonist 9.05
d(CH2)5[Tyr(Me)2,Thr4,Phe(3I,4N3)-NH29]OVT Antagonist Antagonist 9
difluorophenyl-dihydro-indenyl isobutyl-dioxopiperazinyl-isopropylethanamide Antagonist Antagonist 8.9
[3H]AVP Agonist Partial agonist 8.9
SSR149415 Antagonist Antagonist 8.8
[Phe3]OT Agonist Full agonist 8.8
L-371,257 Antagonist Antagonist 8.8
L-366,948 Antagonist Antagonist 8.6
L-368,930 Antagonist Antagonist 8.5
L-365,209 Antagonist Antagonist 8.5
L-369,020 Antagonist Antagonist 8.5
desGlyNH2-d(CH2)5[Tyr(Me)2,Thr4,Orn8]OT Antagonist Antagonist 8.5
[Thr4,Gly7]OT Agonist Full agonist 8.4
L-372662 Antagonist Antagonist 8.4
L-368,228 Antagonist Antagonist 8.4
L-366,682 Antagonist Antagonist 8.4
d(CH2)5[Tyr(Me)2]AVP Antagonist Antagonist 8.3
[111In]DOTA-dLVT None None 8.3
dAVP Agonist Full agonist 8.3
L-368,899 Antagonist Antagonist 8.1
L-367,938 Antagonist Antagonist 7.9
LS-192629 Antagonist Antagonist 7.8
d[Cha4]AVP Agonist Full agonist 7.7
desmopressin Agonist Full agonist 7.6
[Mpa1,D-Tyr(Et)2,D-Tic7,D-Tic9]OT Antagonist Antagonist 7.6
atosiban Antagonist Antagonist 7.6
L-367,773 Antagonist Antagonist 7.6
[Mpa1,D-Tyr(Et)2,D-Tic7]OT Antagonist Antagonist 7.3
[Mpa1,D-Tyr(Et)2,D-Tic7,Aib9]OT Antagonist Antagonist 7.1
SR 49059 Antagonist Antagonist 7
OPC-21268 Antagonist Antagonist 6.8
d[Leu4]AVP Agonist Full agonist 6.7
L-366,509 Antagonist Antagonist 6.6

(62) Novoseek inferred chemical compound relationships for OXTR Gene

Compound -log(P) Hits PubMed IDs
atosiban 94.8 42
ovta 82.3 3
barusiban 78 4
carbetocin 77.6 3
prostaglandin f2alpha 72.6 16
genes like me logo Genes that share compounds with OXTR: view

Transcripts for OXTR Gene

Unigene Clusters for OXTR Gene

Oxytocin receptor:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OXTR

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OXTR Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b · 4c · 4d ^ 5 ^ 6
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for OXTR Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OXTR Gene

mRNA expression in normal human tissues for OXTR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OXTR Gene

This gene is overexpressed in Breast - Mammary Tissue (11.5).

Protein differential expression in normal tissues for OXTR Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (52.3) and Platelet (14.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OXTR Gene

SOURCE GeneReport for Unigene cluster for OXTR Gene Hs.2820

genes like me logo Genes that share expressions with OXTR: view

Expression partners for OXTR Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for OXTR Gene

Orthologs for OXTR Gene

This gene was present in the common ancestor of animals.

Orthologs for OXTR Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OXTR 35
  • 88.32 (n)
  • 89.95 (a)
  • 90 (a)
(Canis familiaris)
Mammalia OXTR 35
  • 90.94 (n)
  • 92.93 (a)
  • 71 (a)
(Mus musculus)
Mammalia Oxtr 35
  • 87.01 (n)
  • 92.2 (a)
Oxtr 16
Oxtr 36
  • 92 (a)
(Pan troglodytes)
Mammalia OXTR 35
  • 99.23 (n)
  • 98.97 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Oxtr 35
  • 87.37 (n)
  • 91.67 (a)
(Monodelphis domestica)
Mammalia OXTR 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia OXTR 36
  • 79 (a)
(Gallus gallus)
Aves OXTR 35
  • 77.91 (n)
  • 77.91 (a)
  • 74 (a)
(Anolis carolinensis)
Reptilia OXTR 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493876 35
  • 70.22 (n)
  • 71.95 (a)
(Danio rerio)
Actinopterygii oxtrl 35
  • 68.1 (n)
  • 70.77 (a)
oxtr 36
  • 63 (a)
oxtrl 36
  • 65 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6111 37
  • 29 (a)
  • 31 (a)
Species with no ortholog for OXTR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OXTR Gene

Gene Tree for OXTR (if available)
Gene Tree for OXTR (if available)

Paralogs for OXTR Gene

Paralogs for OXTR Gene

(5) SIMAP similar genes for OXTR Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with OXTR: view

Variants for OXTR Gene

Sequence variations from dbSNP and Humsavar for OXTR Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs144731267 -- 8,757,180(+) GGAGG(C/T)GGCAC intron-variant
rs144662342 -- 8,766,424(+) TTGCC(A/C)CACCT intron-variant
rs144366756 -- 8,767,424(+) GGGCC(A/C)CGCGC missense, reference
rs148034099 -- 8,753,103(+) CTGGC(A/G)GAGCA reference, synonymous-codon
rs147796195 -- 8,764,839(+) CCTGC(C/T)GGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OXTR Gene

Variant ID Type Subtype PubMed ID
nsv876514 CNV Gain 21882294
nsv516057 CNV Loss 19592680
dgv5104n71 CNV Loss 21882294
nsv819115 CNV Gain 19587683

Relevant External Links for OXTR Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXTR Gene

Disorders for OXTR Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for OXTR Gene in MalaCards »

(4) Diseases for OXTR Gene

(2) University of Copenhagen DISEASES for OXTR Gene

(25) Novoseek inferred disease relationships for OXTR Gene

Disease -log(P) Hits PubMed IDs
dysmenorrhea 53 6
autistic 41.2 4
preterm delivery 36.7 1
chorioamnionitis 19.8 2
leiomyoma 14 7

Relevant External Links for OXTR

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with OXTR: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for OXTR Gene

Publications for OXTR Gene

  1. Association between the oxytocin receptor (OXTR) gene and autism: relationship to Vineland Adaptive Behavior Scales and cognition. (PMID: 17893705) Lerer E. … Ebstein R.P. (Mol. Psychiatry 2008) 3 23 48
  2. The oxytocin receptor (OXTR) contributes to prosocial fund allocations in the dictator game and the social value orientations task. (PMID: 19461999) Israel S. … Ebstein R.P. (PLoS ONE 2009) 3 23 48
  3. Association of the oxytocin receptor (OXTR) gene polymorphisms with autism spectrum disorder (ASD) in the Japanese population. (PMID: 20094064) Liu X. … Sasaki T. (J. Hum. Genet. 2010) 3 23 48
  4. Oxytocin receptor (OXTR) does not play a major role in the aetiology of autism: genetic and molecular studies. (PMID: 20303388) Tansey K.E. … Anney R.J. (Neurosci. Lett. 2010) 3 23 48
  5. Structure and expression of a human oxytocin receptor. (PMID: 1313946) Kimura T. … Okayama H. (Nature 1992) 2 3 4

Products for OXTR Gene

Sources for OXTR Gene

Back to Top