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OXT Gene

protein-coding   GIFtS: 61
GCID: GC20P003064

Oxytocin/Neurophysin I Prepropeptide

(Previous names: oxytocin, prepro- (neurophysin I), oxytocin, prepropeptide)
(Previous symbol: OT)
  See OXT-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oxytocin/Neurophysin I Prepropeptide1 2     OT-NPI2 3
OT1 2 3     oxytocin1
Oxytocin, Prepro- (Neurophysin I)1 2     OXT-NPI2
Oxytocin, Prepropeptide1 2     Oxytocin-Neurophysin 12
Neurophysin I1 2     Oxytocin-Neurophysin I, Preproprotein2

External Ids:    HGNC: 85281   Entrez Gene: 50202   Ensembl: ENSG000001014057   OMIM: 1670505   UniProtKB: P011783   

Export aliases for OXT gene to outside databases

Previous GC identifers: GC20P003040 GC20P003000 GC20P003047


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for OXT Gene:
This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a
posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its
carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and
transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the
bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior
pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in
cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water
excretion and cardiovascular functions. (provided by RefSeq, Dec 2013)

GeneCards Summary for OXT Gene:
OXT (oxytocin/neurophysin I prepropeptide) is a protein-coding gene. Diseases associated with OXT include epignathus, and persistent genital arousal disorder. GO annotations related to this gene include neurohypophyseal hormone activity and oxytocin receptor binding. An important paralog of this gene is AVP.

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178
Function: Neurophysin 1 specifically binds oxytocin
Function: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland

Gene Wiki entry for OXT (Oxytocin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the OXT gene promoter:
         CREB   GR   deltaCREB   GR-beta   c-Myb   POU3F2 (N-Oct-5b)   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOXT promoter sequence
   Search Chromatin IP Primers for OXT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OXT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

OXT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OXT gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P003064:  view genomic region     (about GC identifiers)

Start:
3,052,266 bp from pter      End:
3,053,163 bp from pter
Size:
898 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178 (See protein sequence)
Recommended Name: Oxytocin-neurophysin 1 precursor  
Size: 125 amino acids; 12722 Da
Secondary accessions: Q3MIG0

Explore the universe of human proteins at neXtProt for OXT: NX_P01178

Explore proteomics data for OXT at MOPED


See OXT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_000906.1  
ENSEMBL proteins: 
 ENSP00000217386  
Reactome Protein details: P01178

OXT Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
ENDOLIG: Endogenous ligands

2 InterPro protein domains:
 IPR022423 Neurohypophysial_hormone_CS
 IPR000981 Neurhyp_horm

Graphical View of Domain Structure for InterPro Entry P01178

ProtoNet protein and cluster: P01178

1 Blocks protein domain: IPB000981 Neurohypophysial hormone

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178
Similarity: Belongs to the vasopressin/oxytocin family


Find genes that share domains with OXT           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: NEU1_HUMAN, P01178
Function: Neurophysin 1 specifically binds oxytocin
Function: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland

     Genatlas biochemistry entry for OXT:
oxytocin,prepro- (neurophysin 1)

     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005185neurohypophyseal hormone activity IEA--
GO:0005515protein binding ----
GO:0031855oxytocin receptor binding IEA--
     
Find genes that share ontologies with OXT           About GenesLikeMe


Phenotypes:
     12 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Oxt):
 adipose tissue  behavior/neurological  cardiovascular system  digestive/alimentary  endocrine/exocrine gland 
 growth/size/body  homeostasis/metabolism  integument  mortality/aging  nervous system 
 renal/urinary system  reproductive system 

Find genes that share phenotypes with OXT           About GenesLikeMe

Animal Models:
     MGI mouse knock-outs for OXT: Oxttm1Wsy Oxttm1Zuk Oxttm3Ljm Oxttm1Ljm Oxttm2Ljm

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OXT
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OXT

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OXT
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OXT

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Addgene plasmids for OXT 

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
NEU1_HUMAN, P01178: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
nucleus2

Gene Ontology (GO): 5 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--
GO:0005737cytoplasm ----
GO:0030141secretory granule IEA--
GO:0043195terminal bouton IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for OXT About    
See pathways by source

SuperPathContained pathways About
1Peptide ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
Vasopressin-like receptors0.00
2Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.58
GPCR downstream signaling0.90
3Gastrin-CREB signalling pathway via PKC and MAPK
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90
4Myometrial Relaxation and Contraction Pathways
Myometrial Relaxation and Contraction Pathways0.43
5Oxytocin signaling pathway
Oxytocin signaling pathway0.32


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Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for OXT
    Myometrial Relaxation and Contraction Pathways

2 Reactome Pathways for OXT
    G alpha (q) signalling events
Vasopressin-like receptors


1 Kegg Pathway  (Kegg details for OXT):
    Oxytocin signaling pathway

    Pathway & Disease-focused RT2 Profiler PCR Array including OXT: 
          Osmotic Stress in human mouse rat

Interactions:

    GeneGlobe Interaction Network for OXT

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for OXT (P011781, 3 ENSP000002173864) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
InteractantInteraction Details
GeneCardExternal ID(s)
NCK1P163331, 3, ENSP000002889864EBI-1762651,EBI-389883 I2D: score=2 STRING: ENSP00000288986
TXNDC17Q9BRA23, ENSP000002501014I2D: score=2 STRING: ENSP00000250101
ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
PREPP481473, ENSP000003581064I2D: score=1 STRING: ENSP00000358106
OXTRP305593, ENSP000003242704I2D: score=1 STRING: ENSP00000324270
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Gene Ontology (GO): Selected biological process terms (see all 48):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001975response to amphetamine IEA--
GO:0002027regulation of heart rate IEA--
GO:0002125maternal aggressive behavior IEA--
GO:0007165signal transduction TAS10218979
GO:0007204positive regulation of cytosolic calcium ion concentration IEA--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for OXT available from Tocris Bioscience    About this table
CompoundAction CAS #
OxytocinInvolved in uterine contraction and lactation[50-56-6]
L-368,899 hydrochloride Potent, non-peptide oxytocin receptor antagonist [148927-60-0]
WAY 267464 dihydrochloridePotent non-peptide oxytocin receptor agonist[847375-16-0]
CarbetocinOxytocin analog[37025-55-1]
L-371,257 Potent and selective oxytocin receptor antagonist[162042-44-6]

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178
Pharmaceutical: Oxytocin is available under the names Pitocin (Parke-Davis) and Syntocinon (Sandoz). Used to
artificially speed or induce labor

1 HMDB Compound for OXT    About this table
CompoundSynonyms CAS #PubMed Ids
Oxytocin(Arg8)-Vasopressin (see all 22)50-56-6--

1 DrugBank Compound for OXT    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
OxytocinPitocin (see all 2)50-56-6targetbinder6687626 17016423 1486803

Selected Novoseek inferred chemical compound relationships for OXT gene (see all 134)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
misoprostol 92.1 677 15229013 (9), 12789117 (9), 17321529 (8), 16753768 (8) (see all 99)
atosiban 90.4 123 10191468 (5), 14592588 (4), 8952002 (3), 18683742 (3) (see all 59)
carbetocin 87.1 90 19616358 (7), 19229549 (7), 16769107 (6), 17636798 (6) (see all 26)
methylergometrine 83.9 54 19628206 (5), 17091409 (4), 16634548 (3), 2245955 (2) (see all 32)
deaminooxytocin 83.5 7 8875590 (2), 1472646 (2), 9083475 (2), 8589250 (1)
syntometrine 83.3 36 11802188 (5), 10796180 (4), 7774741 (4), 11905429 (3) (see all 18)
13,14-dihydro-15-ketoprostaglandin f2alpha 82.7 33 1475375 (2), 9437586 (2), 7616495 (2), 9640273 (2) (see all 25)
syntocinon 82.4 20 12757361 (2), 10668163 (1), 1626855 (1), 15512541 (1) (see all 18)
ergonovine 81 119 20124553 (7), 8306013 (5), 17578351 (4), 17701671 (4) (see all 48)
cervidil 80.8 9 9822496 (5), 9322631 (1), 14749647 (1)



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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for OXT gene: 
NM_000915.3  

Unigene Cluster for OXT:

Oxytocin/neurophysin I prepropeptide
Hs.113216  [show with all ESTs]
Unigene Representative Sequence: NM_000915
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000217386(uc002wht.1)
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Addgene plasmids for OXT 
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  QuantiFast Probe-based Assays in human, mouse, rat OXT

Additional mRNA sequence: 

BC069144.1 BC101841.1 BC101843.1 M25650.1 M62611.1 X03173.1 

1 DOTS entry:

DT.306364 

7 AceView cDNA sequences:

AW270827 AW242780 X03173 BC069144 NM_000915 M25650 M62611 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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OXT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCGGCCCCA
OXT Expression
About this image


OXT expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Brain (Nervous System)    fully expand to see all 9 entries
         Thalamus
         Olfactory Bulb   
 
 Ovary (Reproductive System)
         Secondary Oocyte Antral Follicle
 
 Gonad
         Secondary Oocyte Antral Follicle
OXT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

OXT Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.113216
    Pathway & Disease-focused RT2 Profiler PCR Array including OXT: 
          Osmotic Stress in human mouse rat

Primer
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QuantiFast Probe-based Assays in human, mouse, rat OXT
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXT

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for OXT gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Oxt1 , 5 oxytocin1, 5 86.93(n)1
87.2(a)1
  2 (63.24 cM)5
184291  NM_011025.31  NP_035155.11 
 1305761735 
chicken
(Gallus gallus)
Aves OXT1 oxytocin, prepro- (neurophysin I) 71.34(n)
68.22(a)
  768516  XM_001231491.3  XP_001231492.3 
tropical clawed frog
(Xenopus tropicalis)
Amphibia LOC1004856851 mesotocin-neurophysin MT-like 66.98(n)
69.16(a)
  100485685  XM_002936359.2  XP_002936405.1 
zebrafish
(Danio rerio)
Actinopterygii itnp2 isotocin neurophysin 71.85(n)   352920  AY069956.1 


ENSEMBL Gene Tree for OXT (if available)
TreeFam Gene Tree for OXT (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for OXT gene
AVP2  
1 SIMAP similar gene for OXT using alignment to 1 protein entry:     NEU1_HUMAN:
AVP

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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for OXT (see all 87)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs61330101,2
C,F,A,H--3050301(+) CCCTGA/GGCCAG 1 -- us2k114Minor allele frequency- N:0.02NS EA NA WA 884
rs37612461,2
C,F--3050335(+) GCTCTC/AGAGGA 1 -- us2k18Minor allele frequency- A:0.17NS EA NA CSA 661
rs37612481,2
C,F--3050393(+) GCAGGT/CGCTTT 1 -- us2k18Minor allele frequency- C:0.18NS EA NA CSA 663
rs787374531,2
F--3050429(+) TTTCCT/CTTCTT 1 -- us2k11Minor allele frequency- C:0.04WA 118
rs1411271371,2
--3050459(+) ACCTCC/TCCCAC 1 -- us2k10--------
rs1848771901,2
--3050488(+) CTTTTA/CATTAT 1 -- us2k10--------
rs114814161,2
C--3050529(+) AAAAA-/TAATTT 1 -- us2k1 trp30--------
rs20168991,2
C,A--3050531(+) AAAAAT/ATTTTT 1 -- us2k1 trp32Minor allele frequency- A:0.25WA NA 4
rs750551721,2
C--3050531(+) AAAAA-/TTTTTT 1 -- us2k10--------
rs61390021,2
A--3050537(+) TTTTTA/TTTTTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for OXT (3052266 - 3053163 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for OXT:    About this table    
Variant IDTypeSubtypePubMed ID
nsv833897CNV Loss17160897
nsv523746CNV Loss19592680
nsv912603CNV Gain21882294

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing OXT
DNA2.0 Custom Variant and Variant Library Synthesis for OXT

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 167050    OMIM disorders: --

16 diseases for OXT:    
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epignathus    persistent genital arousal disorder    erb's palsy    sexual disorder
gestational trophoblastic tumor    dissecting aortic aneurysm    fetal macrosomia    placenta accreta
neurohypophyseal diabetes insipidus    premature ejaculation    meconium aspiration syndrome    postpartum depression
morphine dependence    oligohydramnios    polyhydramnios    serotonin syndrome

4 diseases from the University of Copenhagen DISEASES database for OXT:
Autistic disorder     Neurohypophyseal diabetes insipidus     Borderline personality disorder     Diabetes insipidus

Find genes that share disorders with OXT           About GenesLikeMe

Selected Novoseek inferred disease relationships for OXT gene (see all 92)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
postpartum hemorrhage 88.8 94 11802188 (4), 15103233 (4), 17578351 (4), 12179676 (4) (see all 60)
uterine atony 84.8 40 20238255 (3), 10076146 (3), 19733052 (2), 11530117 (2) (see all 26)
fetal distress 78 26 8233251 (3), 9141942 (1), 11730496 (1), 19034471 (1) (see all 23)
cephalopelvic disproportion 74.1 7 1445129 (1), 11080926 (1), 15770303 (1), 2145531 (1) (see all 7)
pregnancy prolonged 74 10 1892182 (2), 1398272 (2), 11928554 (1), 11883268 (1) (see all 8)
chorioamnionitis 72.6 38 1579312 (3), 9170488 (3), 10796160 (2), 10796161 (2) (see all 25)
labor prolonged 72.2 13 16949410 (2), 11883027 (1), 10368493 (1), 11120525 (1) (see all 12)
endometritis 63.5 11 8841214 (3), 9170488 (2), 19933542 (1), 17636608 (1) (see all 7)
isthmus uteri 61.6 3 16720280 (2)
fetal macrosomia 61 3 11958242 (1), 10190670 (1), 12596626 (1)

Genetic Association Database (GAD): OXT
Human Genome Epidemiology (HuGE) Navigator: OXT (21 documents)

Export disorders for OXT gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for OXT gene, integrated from 10 sources (see all 1939):
(articles sorted by number of sources associating them with OXT)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Polymorphism in the oxytocin promoter region in patients with lactase non-persistence is not related to symptoms. (PubMed id 19943975)1, 4, 9 Truedsson M....Ohlsson B. (BMC Gastroenterol 2009)
  2. The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization. (PubMed id 1486803)1, 7, 9 Rao V.V....Hansmann I. (Cytogenet. Cell Genet. 1992)
  3. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (Pharmacogenomics 2010)
  4. No association between oxytocin or prolactin gene variants and childhood-onset mood disorders. (PubMed id 20547007)1, 4 Strauss J.S....Kennedy J.L. (Psychoneuroendocrinology 2010)
  5. Polymorphisms of candidate genes in Slovak autistic patients. (PubMed id 20436377)1, 4 Kelemenova S....Ostatnikova D. (Psychiatr. Genet. 2010)
  6. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
  7. Mutation analysis of oxytocin gene in individuals with adult separation anxiety. (PubMed id 19473710)1, 4 Costa B....Cassano G.B. (Psychiatry Res 2009)
  8. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (Biol. Psychiatry 2009)
  9. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)1, 4 Dagle J.M....Murray J.C. (Pediatrics 2009)
  10. Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment. (PubMed id 19086053)1, 4 GratacA^s M....Carracedo A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5020 HGNC: 8528 AceView: OXT Ensembl:ENSG00000101405 euGenes: HUgn5020
ECgene: OXT Kegg: 5020 H-InvDB: OXT

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for OXT Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Oxytocin

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OXT gene:
Search GeneIP for patents involving OXT

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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