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Aliases for OXT Gene

Aliases for OXT Gene

  • Oxytocin/Neurophysin I Prepropeptide 2 3
  • Oxytocin, Prepro- (Neurophysin I) 2 3
  • Oxytocin, Prepropeptide 2 3
  • Neurophysin I 2 3
  • OT-NPI 3 4
  • OT 3 4
  • Oxytocin-Neurophysin I, Preproprotein 3
  • Oxytocin-Neurophysin 1 3
  • Oxytocin 2
  • OXT-NPI 3

External Ids for OXT Gene

Previous Symbols for OXT Gene

  • OT

Summaries for OXT Gene

Entrez Gene Summary for OXT Gene

  • This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]

GeneCards Summary for OXT Gene

OXT (Oxytocin/Neurophysin I Prepropeptide) is a Protein Coding gene. Diseases associated with OXT include epignathus and erbs palsy. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include neurohypophyseal hormone activity and oxytocin receptor binding. An important paralog of this gene is AVP.

UniProtKB/Swiss-Prot for OXT Gene

  • Neurophysin 1 specifically binds oxytocin

  • Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland

Gene Wiki entry for OXT Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXT Gene

Genomics for OXT Gene

Genomic Location for OXT Gene

Start:
3,071,620 bp from pter
End:
3,072,517 bp from pter
Size:
898 bases
Orientation:
Plus strand

Genomic View for OXT Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OXT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXT Gene

Regulatory Elements for OXT Gene

Proteins for OXT Gene

  • Protein details for OXT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01178-NEU1_HUMAN
    Recommended name:
    Oxytocin-neurophysin 1
    Protein Accession:
    P01178
    Secondary Accessions:
    • Q3MIG0

    Protein attributes for OXT Gene

    Size:
    125 amino acids
    Molecular mass:
    12722 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OXT Gene

Proteomics data for OXT Gene at MOPED

Post-translational modifications for OXT Gene

No Post-translational modifications

Other Protein References for OXT Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OXT Gene

Domains for OXT Gene

Gene Families for OXT Gene

HGNC:

Protein Domains for OXT Gene

UniProtKB/Swiss-Prot:

NEU1_HUMAN
Family:
  • Belongs to the vasopressin/oxytocin family.:
    • P01178
genes like me logo Genes that share domains with OXT: view

Function for OXT Gene

Molecular function for OXT Gene

GENATLAS Biochemistry: oxytocin,prepro- (neurophysin 1)
UniProtKB/Swiss-Prot Function: Neurophysin 1 specifically binds oxytocin
UniProtKB/Swiss-Prot Function: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland

Gene Ontology (GO) - Molecular Function for OXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005185 neurohypophyseal hormone activity IEA --
GO:0005515 protein binding --
GO:0031855 oxytocin receptor binding IEA --
genes like me logo Genes that share ontologies with OXT: view
genes like me logo Genes that share phenotypes with OXT: view

Animal Models for OXT Gene

MGI Knock Outs for OXT:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for OXT Gene

Localization for OXT Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OXT Gene COMPARTMENTS Subcellular localization image for OXT gene
Compartment Confidence
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for OXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm --
GO:0030141 secretory granule IEA --
GO:0043195 terminal bouton IEA --
genes like me logo Genes that share ontologies with OXT: view

Pathways for OXT Gene

genes like me logo Genes that share pathways with OXT: view

Gene Ontology (GO) - Biological Process for OXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0002027 regulation of heart rate IEA --
GO:0002125 maternal aggressive behavior IEA --
GO:0007165 signal transduction TAS 10218979
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with OXT: view

Compounds for OXT Gene

UniProtKB/Swiss-Prot:

P01178-NEU1_HUMAN
Pharmaceutical: Oxytocin is available under the names Pitocin (Parke-Davis) and Syntocinon (Sandoz). Used to artificially speed or induce labor

(5) Tocris Compounds for OXT Gene

Compound Action Cas Number
Carbetocin Oxytocin analog [37025-55-1]
L-368,899 hydrochloride Potent, non-peptide oxytocin receptor antagonist [148927-60-0]
L-371,257 Potent and selective oxytocin receptor antagonist [162042-44-6]
Oxytocin Involved in uterine contraction and lactation [50-56-6]
WAY 267464 dihydrochloride Potent non-peptide oxytocin receptor agonist [847375-16-0]

(1) HMDB Compounds for OXT Gene

Compound Synonyms Cas Number PubMed IDs
Oxytocin
  • (Arg8)-Vasopressin
50-56-6

(1) Drugbank Compounds for OXT Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Oxytocin
  • Pitocin
50-56-6 target binder

(134) Novoseek inferred chemical compound relationships for OXT Gene

Compound -log(P) Hits PubMed IDs
misoprostol 92.1 417
atosiban 90.4 95
carbetocin 87.1 70
methylergometrine 83.9 45
deaminooxytocin 83.5 7
genes like me logo Genes that share compounds with OXT: view

Transcripts for OXT Gene

mRNA/cDNA for OXT Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OXT Gene

Oxytocin/neurophysin I prepropeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OXT Gene

No ASD Table

Relevant External Links for OXT Gene

GeneLoc Exon Structure for
OXT
ECgene alternative splicing isoforms for
OXT

Expression for OXT Gene

mRNA expression in normal human tissues for OXT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OXT Gene

This gene is overexpressed in Brain - Hypothalamus (51.9).

SOURCE GeneReport for Unigene cluster for OXT Gene Hs.113216

genes like me logo Genes that share expressions with OXT: view

Orthologs for OXT Gene

This gene was present in the common ancestor of chordates.

Orthologs for OXT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OXT 36
  • 98.67 (n)
  • 98.4 (a)
OXT 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OXT 36
  • 89.6 (n)
  • 88 (a)
OXT 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OXT 36
  • 91.2 (n)
  • 86.4 (a)
OXT 37
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oxt 36
  • 86.93 (n)
  • 87.2 (a)
Oxt 16
Oxt 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 48 (a)
ManyToMany
-- 37
  • 71 (a)
ManyToMany
-- 37
  • 46 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 74 (a)
ManyToMany
-- 37
  • 51 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Oxt 36
  • 87.2 (n)
  • 88 (a)
chicken
(Gallus gallus)
Aves MST 37
  • 66 (a)
OneToMany
OXT 36
  • 71.34 (n)
  • 68.22 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485685 36
  • 66.98 (n)
  • 69.16 (a)
zebrafish
(Danio rerio)
Actinopterygii itnp 36
oxt 37
  • 44 (a)
OneToMany
Species with no ortholog for OXT:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OXT Gene

ENSEMBL:
Gene Tree for OXT (if available)
TreeFam:
Gene Tree for OXT (if available)

Paralogs for OXT Gene

Paralogs for OXT Gene

Selected SIMAP similar genes for OXT Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OXT: view

Variants for OXT Gene

Structural Variations from Database of Genomic Variants (DGV) for OXT Gene

Variant ID Type Subtype PubMed ID
nsv912603 CNV Gain 21882294
nsv833897 CNV Loss 17160897
nsv523746 CNV Loss 19592680

Relevant External Links for OXT Gene

HapMap Linkage Disequilibrium report
OXT

No data available for Sequence variations from dbSNP and Humsavar for OXT Gene

Disorders for OXT Gene

(92) Novoseek inferred disease relationships for OXT Gene

Disease -log(P) Hits PubMed IDs
postpartum hemorrhage 88.8 84
uterine atony 84.8 33
fetal distress 78 25
cephalopelvic disproportion 74.1 7
pregnancy prolonged 74 10

Relevant External Links for OXT

Genetic Association Database (GAD)
OXT
Human Genome Epidemiology (HuGE) Navigator
OXT
genes like me logo Genes that share disorders with OXT: view

No data available for UniProtKB/Swiss-Prot for OXT Gene

Publications for OXT Gene

  1. The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization. (PMID: 1486803) Rao V.V. … Hansmann I. (Cytogenet. Cell Genet. 1992) 3 23 25
  2. Paracrine oxytocin and estradiol demonstrate a spatial increase in human intrauterine tissues with labor. (PMID: 12843193) Blanks A.M. … Thornton S. (J. Clin. Endocrinol. Metab. 2003) 3 23
  3. Effects of emotion on oxytocin, prolactin, and ACTH in women. (PMID: 12475731) Turner R.A. … Amico J.A. (Stress 2002) 3 23
  4. The effect of oxytocin on cell proliferation in the human prostate is modulated by gonadal steroids: implications for benign prostatic hyperplasia and carcinoma of the prostate. (PMID: 17492653) Whittington K. … Nicholson H. (Prostate 2007) 3 23
  5. Oxytocin synthesis and oxytocin receptor expression by cell lines of human small cell carcinoma of the lung stimulate tumor growth through autocrine/paracrine signaling. (PMID: 12183418) PAcqueux C. … Legros J.J. (Cancer Res. 2002) 3 23

Products for OXT Gene

  • Addgene plasmids for OXT

Sources for OXT Gene

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