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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OXT Gene

protein-coding GIFtS: 61
GCID: GC20P003047

oxytocin/neurophysin I prepropeptide

(Previous names: oxytocin, prepro- (neurophysin I), oxytocin, prepropeptide...)
(Previous symbol: OT)

Explore 97 diseases affiliated with
OXT via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Oxytocin/Neurophysin I Prepropeptide¹ ²		Oxytocin, Prepropeptide¹ ²
OT¹ ² ³		Neurophysin I²
OT-NPI¹ ² ³		Oxytocin-Neurophysin 1²
OXT-NPI¹ ²		Oxytocin-Neurophysin I, Preproprotein²
Oxytocin, Prepro- (Neurophysin I)¹ ²

External Ids:	HGNC: 8528¹	Entrez Gene: 5020²	Ensembl: ENSG00000101405⁷	OMIM: 167050⁵	UniProtKB: P01178³

Export aliases for OXT gene to outside databases

Previous GC identifers: GC20P003040 GC20P003000

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OXT:

There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which

is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together

with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the

neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while

it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during

parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal

behaviour, as well as in the regulation of water excretion and cardiovascular functions. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178

Function: Neurophysin 1 specifically binds oxytocin

Function: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland

Gene Wiki entry for OXT (Oxytocin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000020.10 NC_018931.1 NT_011387.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OXT gene promoter:
CREB GR deltaCREB GR-beta c-Myb POU3F2 (N-Oct-5b) GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: OXT promoter sequence

Search SABiosciences Chromatin IP Primers for OXT

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OXT

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13 Ensembl cytogenetic band: 20p13 HGNC cytogenetic band: 20p13

OXT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OXT gene location

GeneLoc information about chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P003047: view genomic region (about GC identifiers)

Start:	3,052,266 bp from pter	End:	3,053,163 bp from pter
Size:	898 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178 (See protein sequence)

Recommended Name: Oxytocin-neurophysin 1 precursor

Size: 125 amino acids; 12722 Da

Subcellular location: Secreted

Secondary accessions: Q3MIG0

Explore the universe of human proteins at neXtProt for OXT: NX_P01178

OXT Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000906.1

ENSEMBL proteins:

ENSP00000217386

Reactome Protein details: P01178
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
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	ProSpec Recombinant Protein for OXT
	Uscn Proteins for OXT

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	IEA	--
GO:0005737	cytoplasm	--	--
GO:0030141	secretory granule	IEA	--
GO:0043195	terminal bouton	IEA	--

OXT for ontologies About GeneDecksing

OXT Antibody Products:

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Assay Products for OXT:

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	GenScript Custom Assay Services for OXT
	Enzo Life Sciences assays for OXT
	Uscn ELISAs and CLIAs for OXT

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OXT for domains About GeneDecksing

2 InterPro domains/families:

IPR022423 Neurohypophysial_hormone_CS

IPR000981 Neurhyp_horm

Graphical View of Domain Structure for InterPro Entry P01178

ProtoNet protein and cluster: P01178

1 Blocks protein family: IPB000981 Neurohypophysial hormone

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178

Similarity: Belongs to the vasopressin/oxytocin family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178

Function: Neurophysin 1 specifically binds oxytocin

Function: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland

Genatlas biochemistry entry for OXT:

oxytocin,prepro- (neurophysin 1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OXT
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate OXT
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OXT (see all 7) OriGene shRNA RFP: OXT OriGene siRNA: OXT
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for OXT

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for OXT
		Search LifeMap BioReagents cell lines for OXT

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for OXT

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005184	neuropeptide hormone activity	--	--
GO:0005185	neurohypophyseal hormone activity	IEA	--
GO:0005515	protein binding	--	--
GO:0031855	oxytocin receptor binding	IEA	--

OXT for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for OXT: Oxt^tm1Wsy Oxt^tm1Zuk Oxt^tm3Ljm Oxt^tm1Ljm Oxt^tm2Ljm
     10 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Oxt):

behavior/neurological	cardiovascular system	digestive/alimentary	endocrine/exocrine gland	homeostasis/metabolism
integument	mortality/aging	nervous system	renal/urinary system	reproductive system

OXT for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Peptide ligand-binding receptors	0.61
	GPCR ligand binding	0.75

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Vasopressin-like receptors

Vasopressin-like receptors

1.00

Calcium Regulation in the Cardiac Cell

Myometrial Relaxation and Contraction Pathways

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for OXT

Myometrial Relaxation and Contraction Pathways

5/9 Reactome Pathways for OXT (see all 9)

	GPCR downstream signaling
	Peptide ligand-binding receptors
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	Vasopressin-like receptors

OXT for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for OXT

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/129 Interacting proteins for OXT (P01178^{1, 3} ENSP00000217386⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 129)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCK1	P16333¹^,³, ENSP00000288986⁴	EBI-1762651,EBI-389883 I2D: score=2 STRING: ENSP00000288986
TXNDC17	Q9BRA2³, ENSP00000250101⁴	I2D: score=2 STRING: ENSP00000250101
ESR2	Q92731³, ENSP00000343925⁴	I2D: score=1 STRING: ENSP00000343925
PREP	P48147³, ENSP00000358106⁴	I2D: score=1 STRING: ENSP00000358106
OXTR	P30559³, ENSP00000324270⁴	I2D: score=1 STRING: ENSP00000324270

About this table

Gene Ontology (GO): 5/49 biological process terms (GO ID links to tree view) (see all 49): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001975	response to amphetamine	IEA	--
GO:0002027	regulation of heart rate	IEA	--
GO:0002125	maternal aggressive behavior	IEA	--
GO:0006950	response to stress	--	--
GO:0007165	signal transduction	TAS	10218979

OXT for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

OXT for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Compounds for OXT available from Tocris Bioscience About this table

Compound	Action	CAS #
L-368,899 hydrochloride	Potent, non-peptide oxytocin receptor antagonist	[148927-60-0]
Capsazepine	Vanilloid receptor antagonist. Also activator of ENaCdelta	[138977-28-3]
L-371,257	Potent and selective oxytocin receptor antagonist	[162042-44-6]

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178

Pharmaceutical: Oxytocin is available under the names Pitocin (Parke-Davis) and Syntocinon (Sandoz). Used to

artificially speed or induce labor

1 HMDB Compound for OXT About this table

Compound	Synonyms	CAS #	PubMed Ids
Oxytocin	(Arg8)-Vasopressin (see all 22)	50-56-6	--

1 DrugBank Compound for OXT About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Oxytocin	Pitocin (see all 2)	50-56-6	target	binder	6687626 17016423 1486803

10/134 Novoseek chemical compound relationships for OXT gene (see all 134) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
misoprostol	92.1	677	15229013 (9), 12789117 (9), 17321529 (8), 16753768 (8) (see all 99)
atosiban	90.4	123	10191468 (5), 14592588 (4), 8952002 (3), 18683742 (3) (see all 59)
carbetocin	87.1	90	19616358 (7), 19229549 (7), 16769107 (6), 17636798 (6) (see all 26)
methylergometrine	83.9	54	19628206 (5), 17091409 (4), 16634548 (3), 2245955 (2) (see all 32)
deaminooxytocin	83.5	7	8875590 (2), 1472646 (2), 9083475 (2), 8589250 (1)
syntometrine	83.3	36	11802188 (5), 10796180 (4), 7774741 (4), 11905429 (3) (see all 18)
13,14-dihydro-15-ketoprostaglandin f2alpha	82.7	33	1475375 (2), 9437586 (2), 7616495 (2), 9640273 (2) (see all 25)
syntocinon	82.4	20	12757361 (2), 10668163 (1), 1626855 (1), 15512541 (1) (see all 18)
ergonovine	81	119	20124553 (7), 8306013 (5), 17578351 (4), 17701671 (4) (see all 48)
cervidil	80.8	9	9822496 (5), 9322631 (1), 14749647 (1)

Search CenterWatch for drugs/clinical trials and news about OXT / NEU1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OXT gene:

NM_000915.2

Unigene Cluster for OXT:

Oxytocin/neurophysin I prepropeptide

Hs.113216 [show with all ESTs]

Unigene Representative Sequence: NM_000915

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000217386(uc002wht.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OXT
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		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OXT (see all 7) OriGene shRNA RFP: OXT OriGene siRNA: OXT
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		GenScript: all cDNA clones in your preferred vector: OXT (NM_000915)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OXT

Additional cDNA sequence:

BC069144.1 BC101841.1 BC101843.1 M25650.1 M62611.1 X03173.1

1 DOTS entry:

DT.306364

7 AceView cDNA sequences:

X03173 M25650 NM_000915 AW270827 AW242780 BC069144 M62611

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OXT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCGGCCCCA

About this image

OXT expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Secondary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See OXT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OXT

SOURCE GeneReport for Unigene cluster: Hs.113216

SABiosciences Expression via Pathway-Focused PCR Array including OXT:

Osmotic Stress in human mouse rat

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In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for OXT

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for OXT gene from 2/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	OXT¹	oxytocin, prepro- (neurophysin I)	70.87(n) 68.91(a)		768516 XM_001231491.2 XP_001231492.2
zebrafish (Danio rerio)	Actinopterygii	itnp²	isotocin neurophysin	71.85(n)		352920 AY069956.1

ENSEMBL Gene Tree for OXT (if available)
TreeFam Gene Tree for OXT (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OXT gene

AVP²

1 SIMAP similar gene for OXT using alignment to 1 protein entry: NEU1_HUMAN:

AVP

OXT for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 20 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs6133010^1,2	C,F,A,H,	--	3050301(+)	`CCCTGA/GGCCAG`	1	--	us2k¹		14		NS EA NA WA	884
rs3761246^1,2	C,F,	--	3050335(+)	`GCTCTC/AGAGGA`	1	--	us2k¹		8		NS EA NA CSA	661
rs3761248^1,2	C,F,	--	3050393(+)	`GCAGGT/CGCTTT`	1	--	us2k¹		8		NS EA NA CSA	663
rs78737453^1,2	F,	--	3050429(+)	`TTTCCT/CTTCTT`	1	--	us2k¹		1		WA	118
rs141127137^1,2		--	3050459(+)	`ACCTCC/TCCCAC`	1	--	us2k¹		0	--	--	--	--
rs184877190^1,2		--	3050488(+)	`CTTTTA/CATTAT`	1	--	us2k¹		0	--	--	--	--
rs11481416^1,2	C,	--	3050529(+)	`AAAAA-/TAATTT`	1	--	us2k¹ trp³		0	--	--	--	--
rs2016899^1,2	C,A,	--	3050531(+)	`AAAAAT/ATTTTT`	1	--	us2k¹ trp³		2		WA NA	4
rs75055172^1,2	C	--	3050531(+)	`AAAAA-/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs6139002^1,2	A	--	3050537(+)	`TTTTTA/TTTTTT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for OXT (3052266 - 3053163 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OXT: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OXT

DNA2.0 Custom Variant and Variant Library Synthesis for OXT

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OXT for disorders           About GeneDecksing

OMIM gene information: 167050    OMIM disorders: --

20/97 diseases for OXT (see all 97):    About MalaCards

obsessive-compulsive disorder disseminated intravascular coagulation prader-willi syndrome fetal macrosomia

diabetes insipidus neurohypophyseal diabetes insipidus placenta accreta erb's palsy

dissecting aortic aneurysm patent ductus arteriosus social cognition asperger syndrome

pre-eclampsia gestational trophoblastic tumor postpartum depression anorexia nervosa

back pain morphine dependence anxiety disorder aortic aneurysm

4 diseases from the University of Copenhagen DISEASES database for OXT:

Autistic disorder Neurohypophyseal diabetes insipidus Borderline personality disorder Diabetes insipidus

10/92 Novoseek disease relationships for OXT gene (see all 92) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
postpartum hemorrhage	88.8	94	11802188 (4), 15103233 (4), 17578351 (4), 12179676 (4) (see all 60)
uterine atony	84.8	40	20238255 (3), 10076146 (3), 19733052 (2), 11530117 (2) (see all 26)
fetal distress	78	26	8233251 (3), 9141942 (1), 11730496 (1), 19034471 (1) (see all 23)
cephalopelvic disproportion	74.1	7	1445129 (1), 11080926 (1), 15770303 (1), 2145531 (1) (see all 7)
pregnancy prolonged	74	10	1892182 (2), 1398272 (2), 11928554 (1), 11883268 (1) (see all 8)
chorioamnionitis	72.6	38	1579312 (3), 9170488 (3), 10796160 (2), 10796161 (2) (see all 25)
labor prolonged	72.2	13	16949410 (2), 11883027 (1), 10368493 (1), 11120525 (1) (see all 12)
endometritis	63.5	11	8841214 (3), 9170488 (2), 19933542 (1), 17636608 (1) (see all 7)
isthmus uteri	61.6	3	16720280 (2)
fetal macrosomia	61	3	11958242 (1), 10190670 (1), 12596626 (1)

Human Genome Epidemiology (HuGE) Navigator: OXT (21 documents)

Export disorders for OXT gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OXT gene, integrated from 9 sources (see all 1927):
(articles sorted by number of sources associating them with OXT)

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The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization. (PubMed id 1486803)^{1, 7, 9} Rao V.V....Hansmann I. (1992)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{1, 2} Deloukas P....Rogers J. (2001)
Expression of the oxytocin and vasopressin genes in human and baboon gonadal tissues. (PubMed id 2249637)^{1, 2} Ivell R.... Khan-Dawood F. (1990)
The neurohypophyseal hormones vasopressin and oxytocin. Precursor structure, synthesis and regulation. (PubMed id 3768139)^{1, 2} Rehbein M....Richter D. (1986)
The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line. (PubMed id 2991279)^{1, 2} Sausville E.... Battey J. (1985)
Expression of the vasopressin and oxytocin genes in human hypothalami. (PubMed id 4065330)^{1, 2} Mohr E.... Richter D. (1985)
Identification of human neurophysins: complete amino acid sequences of MSEL- and VLDV-neurophysins. (PubMed id 6574452)^{1, 2} Chauvet M.-T.... Acher R. (1983)
A comparative study of mammalian neurophysin protein sequences. (PubMed id 7262323)^{1, 2} Schlesinger D.H. and Audhya T.K. (1981)
On the nature of oxytocin and vasopressin from human pituitary. (PubMed id 13591312)^{1, 2} Light A. and du Vigneaud V. (1958)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5020	HGNC: 8528	AceView: OXT	Ensembl:ENSG00000101405	euGenes: HUgn5020
ECgene: OXT	H-InvDB: OXT

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for OXT	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Oxytocin

Intellectual Property for OXT gene
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Patent Information for OXT gene:
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oxytocin/neurophysin I prepropeptide

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preterm delivery
LUNG TUMOR
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OXT Gene

oxytocin/neurophysin I prepropeptide

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