Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OXT Gene

Aliases for OXT Gene

  • Oxytocin/Neurophysin I Prepropeptide 2 3 5
  • Oxytocin, Prepro- (Neurophysin I) 2 3
  • Oxytocin, Prepropeptide 2 3
  • Neurophysin I 2 3
  • OT-NPI 3 4
  • OT 3 4
  • Oxytocin-Neurophysin I, Preproprotein 3
  • Oxytocin-Neurophysin 1 3
  • Oxytocin 2
  • OXT-NPI 3

External Ids for OXT Gene

Previous HGNC Symbols for OXT Gene

  • OT

Previous GeneCards Identifiers for OXT Gene

  • GC20P003040
  • GC20P003000
  • GC20P003047

Summaries for OXT Gene

Entrez Gene Summary for OXT Gene

  • This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]

GeneCards Summary for OXT Gene

OXT (Oxytocin/Neurophysin I Prepropeptide) is a Protein Coding gene. Diseases associated with OXT include Endometritis and Persistent Genital Arousal Disorder. Among its related pathways are Signaling by GPCR and Myometrial Relaxation and Contraction Pathways. GO annotations related to this gene include neurohypophyseal hormone activity and oxytocin receptor binding. An important paralog of this gene is AVP.

UniProtKB/Swiss-Prot for OXT Gene

  • Neurophysin 1 specifically binds oxytocin.

  • Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.

Tocris Summary for OXT Gene

  • Oxytocin receptors (OT) are G-protein-coupled receptors that mediate parturition and lactation. They are closely related to vasopressin receptors. Oxytocin receptors are coupled to Gq/11 proteins and are localized to the myoepithelial cells of the mammary gland.

Gene Wiki entry for OXT Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXT Gene

Genomics for OXT Gene

Regulatory Elements for OXT Gene

Enhancers for OXT Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20F003113 0.2 Ensembl 13 +44.4 44430 0.6 ARID1B BHLHE40 EGR2 OXT FASTKD5 UBOX5 MRPS26 GNRH2 DDRGK1 ITPA UBOX5-AS1 GC20P003124
GH20F003106 0.7 Ensembl ENCODE 12.2 +38.2 38245 1.0 ELF3 MLX ARID4B DMAP1 THRB ZNF48 RARA CREM MIXL1 THAP11 LZTS3 MRPS26 GNRH2 OXT UBOX5 ITPA UBOX5-AS1 GC20P003124
GH20F003104 0.6 ENCODE 12.2 +36.2 36199 0.2 CTCF NR2F1 IKZF1 NR2F6 RAD21 HOMEZ LZTS3 MRPS26 GNRH2 OXT UBOX5-AS1 RN7SL555P
GH20F003161 0.2 ENCODE 5.5 +93.1 93114 1.1 TBP SAP130 ZNF121 POLR2A RFXANK PRDM10 ZNF652 THAP11 GATAD2A MAZ OXT UBOX5 PIR60125
GH20F003067 0.7 ENCODE 5.3 -1.0 -1042 0.2 GTF3C2 PAF1 KLF9 HNF4G MAX ELF1 ZBTB40 THAP11 ZNF343 VPS16 OXT GC20P003063
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OXT on UCSC Golden Path with GeneCards custom track

Genomic Location for OXT Gene

Chromosome:
20
Start:
3,068,871 bp from pter
End:
3,072,517 bp from pter
Size:
3,647 bases
Orientation:
Plus strand

Genomic View for OXT Gene

Genes around OXT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OXT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OXT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXT Gene

Proteins for OXT Gene

  • Protein details for OXT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01178-NEU1_HUMAN
    Recommended name:
    Oxytocin-neurophysin 1
    Protein Accession:
    P01178
    Secondary Accessions:
    • Q3MIG0

    Protein attributes for OXT Gene

    Size:
    125 amino acids
    Molecular mass:
    12722 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OXT Gene

Post-translational modifications for OXT Gene

No Post-translational modifications

Other Protein References for OXT Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OXT Gene

Domains & Families for OXT Gene

Gene Families for OXT Gene

Protein Domains for OXT Gene

Suggested Antigen Peptide Sequences for OXT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01178

UniProtKB/Swiss-Prot:

NEU1_HUMAN :
  • Belongs to the vasopressin/oxytocin family.
Family:
  • Belongs to the vasopressin/oxytocin family.
genes like me logo Genes that share domains with OXT: view

Function for OXT Gene

Molecular function for OXT Gene

GENATLAS Biochemistry:
oxytocin,prepro- (neurophysin 1)
UniProtKB/Swiss-Prot Function:
Neurophysin 1 specifically binds oxytocin.
UniProtKB/Swiss-Prot Function:
Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland.

Gene Ontology (GO) - Molecular Function for OXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
GO:0005184 neuropeptide hormone activity IEA --
GO:0005185 neurohypophyseal hormone activity IEA --
GO:0031855 oxytocin receptor binding IEA --
genes like me logo Genes that share ontologies with OXT: view
genes like me logo Genes that share phenotypes with OXT: view

Animal Models for OXT Gene

MGI Knock Outs for OXT:

Animal Model Products

miRNA for OXT Gene

miRTarBase miRNAs that target OXT

Clone Products

  • Addgene plasmids for OXT

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OXT Gene

Localization for OXT Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXT Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OXT Gene COMPARTMENTS Subcellular localization image for OXT gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 3
cytoskeleton 2
endoplasmic reticulum 2
mitochondrion 2
plasma membrane 2
golgi apparatus 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for OXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA,TAS --
GO:0005615 extracellular space IEA --
GO:0005737 cytoplasm IEA --
GO:0030141 secretory granule IEA --
GO:0043195 terminal bouton IEA --
genes like me logo Genes that share ontologies with OXT: view

Pathways & Interactions for OXT Gene

genes like me logo Genes that share pathways with OXT: view

SIGNOR curated interactions for OXT Gene

Activates:

Gene Ontology (GO) - Biological Process for OXT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0002027 regulation of heart rate IEA --
GO:0002125 maternal aggressive behavior IEA --
GO:0007165 signal transduction TAS 10218979
GO:0007204 positive regulation of cytosolic calcium ion concentration IEA --
genes like me logo Genes that share ontologies with OXT: view

Drugs & Compounds for OXT Gene

(83) Drugs for OXT Gene - From: DrugBank, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Oxytocin Approved, Vet_approved Pharma Full agonist, Agonist, agonist, Target, binder Involved in uterine contraction and lactation 408
Carbetocin Approved Pharma Oxytocin analog 35
L-368,899 hydrochloride Pharma Potent, non-peptide oxytocin receptor antagonist 0
L-371,257 Pharma Antagonist Potent and selective oxytocin receptor antagonist 0
WAY 267464 dihydrochloride Pharma Potent non-peptide oxytocin receptor agonist 0

(55) Additional Compounds for OXT Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(5) Tocris Compounds for OXT Gene

Compound Action Cas Number
Carbetocin Oxytocin analog 37025-55-1
L-368,899 hydrochloride Potent, non-peptide oxytocin receptor antagonist 160312-62-9
L-371,257 Potent and selective oxytocin receptor antagonist 162042-44-6
Oxytocin Involved in uterine contraction and lactation 50-56-6
WAY 267464 dihydrochloride Potent non-peptide oxytocin receptor agonist 1432043-31-6
genes like me logo Genes that share compounds with OXT: view

Transcripts for OXT Gene

mRNA/cDNA for OXT Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OXT Gene

Oxytocin/neurophysin I prepropeptide:
Representative Sequences:

Clone Products

  • Addgene plasmids for OXT

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OXT Gene

No ASD Table

Relevant External Links for OXT Gene

GeneLoc Exon Structure for
OXT
ECgene alternative splicing isoforms for
OXT

Expression for OXT Gene

mRNA expression in normal human tissues for OXT Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OXT Gene

This gene is overexpressed in Brain - Hypothalamus (x51.9).

NURSA nuclear receptor signaling pathways regulating expression of OXT Gene:

OXT

SOURCE GeneReport for Unigene cluster for OXT Gene:

Hs.113216
genes like me logo Genes that share expression patterns with OXT: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for OXT Gene

Orthologs for OXT Gene

This gene was present in the common ancestor of chordates.

Orthologs for OXT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OXT 34 35
  • 98.67 (n)
dog
(Canis familiaris)
Mammalia OXT 34 35
  • 91.2 (n)
cow
(Bos Taurus)
Mammalia OXT 34 35
  • 89.6 (n)
rat
(Rattus norvegicus)
Mammalia Oxt 34
  • 87.2 (n)
mouse
(Mus musculus)
Mammalia Oxt 34 16 35
  • 86.93 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 74 (a)
ManyToMany
-- 35
  • 51 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 71 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 46 (a)
ManyToMany
chicken
(Gallus gallus)
Aves OXT 34
  • 71.34 (n)
MST 35
  • 66 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485685 34
  • 66.98 (n)
zebrafish
(Danio rerio)
Actinopterygii oxt 35
  • 44 (a)
OneToMany
itnp 34
Species where no ortholog for OXT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OXT Gene

ENSEMBL:
Gene Tree for OXT (if available)
TreeFam:
Gene Tree for OXT (if available)

Paralogs for OXT Gene

Paralogs for OXT Gene

(1) SIMAP similar genes for OXT Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OXT: view

Variants for OXT Gene

Sequence variations from dbSNP and Humsavar for OXT Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs111504347 -- 3,072,631(+) AAGAC(A/G)TGTCC downstream-variant-500B, upstream-variant-2KB
rs111869749 -- 3,071,940(+) GTCTC(A/G)GCCCC intron-variant
rs112595729 -- 3,071,903(+) CTTGA(A/C)CGCGG intron-variant
rs113571295 -- 3,071,748(+) AAGAG(A/G)GCCGC intron-variant, reference, synonymous-codon
rs114029030 -- 3,072,358(+) CTTCC(C/T)CCAGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OXT Gene

Variant ID Type Subtype PubMed ID
nsv523746 CNV loss 19592680
nsv585276 CNV gain 21841781
nsv833897 CNV loss 17160897

Variation tolerance for OXT Gene

Residual Variation Intolerance Score: 52.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OXT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OXT

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXT Gene

Disorders for OXT Gene

MalaCards: The human disease database

(48) MalaCards diseases for OXT Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
endometritis
persistent genital arousal disorder
  • persistent genital arousal
chorioamnionitis
epignathus
  • oropharyngeal teratoma
neonatal jaundice
  • neonatal hyperbilirubinemia
- elite association - COSMIC cancer census association via MalaCards
Search OXT in MalaCards View complete list of genes associated with diseases

Relevant External Links for OXT

Genetic Association Database (GAD)
OXT
Human Genome Epidemiology (HuGE) Navigator
OXT
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OXT
genes like me logo Genes that share disorders with OXT: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OXT Gene

Publications for OXT Gene

  1. Association study of 182 candidate genes in anorexia nervosa. (PMID: 20468064) Pinheiro A.P. … Woodside D.B. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010) 3 46 64
  2. Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PMID: 20602615) RuaA+o G. … Wu A.H. (Pharmacogenomics 2010) 3 46 64
  3. No association between oxytocin or prolactin gene variants and childhood-onset mood disorders. (PMID: 20547007) Strauss J.S. … Kennedy J.L. (Psychoneuroendocrinology 2010) 3 46 64
  4. Polymorphisms of candidate genes in Slovak autistic patients. (PMID: 20436377) Kelemenova S. … Ostatnikova D. (Psychiatr. Genet. 2010) 3 46 64
  5. Melatonin synergizes with oxytocin to enhance contractility of human myometrial smooth muscle cells. (PMID: 19001515) Sharkey J.T. … Olcese J. (J. Clin. Endocrinol. Metab. 2009) 3 22 64

Products for OXT Gene

Sources for OXT Gene

Content
Loading form....