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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OXT Gene

protein-coding   GIFtS: 61
GCID: GC20P003047

Oxytocin/Neurophysin I Prepropeptide

(Previous names: oxytocin, prepro- (neurophysin I), oxytocin, prepropeptide)
(Previous symbol: OT)
Alzheimer's & Parkinson's Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Oxytocin/Neurophysin I Prepropeptide1 2     OT-NPI2 3
OT1 2 3     oxytocin1
Oxytocin, Prepro- (Neurophysin I)1 2     OXT-NPI2
Oxytocin, Prepropeptide1 2     Oxytocin-Neurophysin 12
Neurophysin I1 2     Oxytocin-Neurophysin I, Preproprotein2

External Ids:    HGNC: 85281   Entrez Gene: 50202   Ensembl: ENSG000001014057   OMIM: 1670505   UniProtKB: P011783   

Export aliases for OXT gene to outside databases

Previous GC identifers: GC20P003040 GC20P003000


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OXT Gene:
This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is
posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its
carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and
transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the
bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior
pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in
cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water
excretion and cardiovascular functions. (provided by RefSeq, Jun 2013)

GeneCards Summary for OXT Gene: 
OXT (oxytocin/neurophysin I prepropeptide) is a protein-coding gene. Diseases associated with OXT include erb's palsy, and epignathus, and among its related super-pathways are Signaling by GPCR and GPCR ligand binding. GO annotations related to this gene include neurohypophyseal hormone activity and oxytocin receptor binding. An important paralog of this gene is AVP.

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178
Function: Neurophysin 1 specifically binds oxytocin
Function: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland

Gene Wiki entry for OXT (Oxytocin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011387.8  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OXT gene promoter:
         CREB   GR   deltaCREB   GR-beta   c-Myb   POU3F2 (N-Oct-5b)   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOXT promoter sequence
   Search SABiosciences Chromatin IP Primers for OXT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OXT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

OXT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OXT gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P003047:  view genomic region     (about GC identifiers)

Start:
3,052,266 bp from pter      End:
3,053,163 bp from pter
Size:
898 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178 (See protein sequence)
Recommended Name: Oxytocin-neurophysin 1 precursor  
Size: 125 amino acids; 12722 Da
Subcellular location: Secreted
Secondary accessions: Q3MIG0

Explore the universe of human proteins at neXtProt for OXT: NX_P01178

Explore proteomics data for OXT at MOPED 

OXT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

OXT Protein Expression

REFSEQ proteins: NP_000906.1  
ENSEMBL proteins: 
 ENSP00000217386  
Reactome Protein details: P01178
Human Recombinant Protein Products for OXT: 
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Browse Sino Biological Cell Lysates 
ProSpec Recombinant Protein for OXT
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region TAS--
GO:0005615extracellular space IEA--
GO:0005737cytoplasm ----
GO:0030141secretory granule IEA--
GO:0043195terminal bouton IEA--

OXT for ontologies           About GeneDecksing



OXT Antibody Products: 
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ThermoFisher Antibody for OXT
LSBio Antibodies in human, mouse, rat for OXT 

Assay Products for OXT: 
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GenScript Custom Assay Services for OXT
Enzo Life Sciences assays for OXT
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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
ENDOLIG: Endogenous ligands

2 InterPro protein domains:
 IPR022423 Neurohypophysial_hormone_CS
 IPR000981 Neurhyp_horm

Graphical View of Domain Structure for InterPro Entry P01178

ProtoNet protein and cluster: P01178

1 Blocks protein domain: IPB000981 Neurohypophysial hormone

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178
Similarity: Belongs to the vasopressin/oxytocin family


OXT for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: NEU1_HUMAN, P01178
Function: Neurophysin 1 specifically binds oxytocin
Function: Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland

     Genatlas biochemistry entry for OXT:
oxytocin,prepro- (neurophysin 1)

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005185neurohypophyseal hormone activity IEA--
GO:0005515protein binding ----
GO:0031855oxytocin receptor binding IEA--
     
OXT for ontologies           About GeneDecksing


Phenotypes:
     10 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Oxt):
 behavior/neurological  cardiovascular system  digestive/alimentary  endocrine/exocrine gland  homeostasis/metabolism 
 integument  mortality/aging  nervous system  renal/urinary system  reproductive system 

OXT for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for OXT: Oxttm1Wsy Oxttm1Zuk Oxttm3Ljm Oxttm1Ljm Oxttm2Ljm

   inGenious Targeting Laboratory - Custom generated mouse model solutions for OXT 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OXT

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OXT 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OXT 

miRNA
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Inhib. RNA
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OriGene RNAi products in human, mouse, rat for OXT
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Gene Editing
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Clone
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OriGene clones in human, mouse for OXT (see all 6)
OriGene ORF clones in mouse, rat for OXT
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: OXT (NM_000915)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for OXT
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXT
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                     Customized lentivirus expression plasmids for stable overexpression of OXT 

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXT


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for OXT About                                                                                                See pathways by source

SuperPathContained pathways About
1Signaling by GPCR
Signaling by GPCR0.90
Signal Transduction0.55
GPCR downstream signaling0.90
2Class A/1 (Rhodopsin-like receptors)
Class A/1 (Rhodopsin-like receptors)0.71
Peptide ligand-binding receptors0.60
GPCR ligand binding0.71
3G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPK0.90
G alpha (q) signalling events0.90
4Calcium Regulation in the Cardiac Cell
Myometrial Relaxation and Contraction Pathways0.43
5Vasopressin-like receptors
Vasopressin-like receptors

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 BioSystems Pathway for OXT
    Myometrial Relaxation and Contraction Pathways

5/9        Reactome Pathways for OXT (see all 9)
    GPCR downstream signaling
Peptide ligand-binding receptors
Gastrin-CREB signalling pathway via PKC and MAPK
Signaling by GPCR
Vasopressin-like receptors



OXT for pathways           About GeneDecksing

Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OXT

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/129 Interacting proteins for OXT (P011781, 3 ENSP000002173864) via UniProtKB, MINT, STRING, and/or I2D (see all 129)
InteractantInteraction Details
GeneCardExternal ID(s)
NCK1P163331, 3, ENSP000002889864EBI-1762651,EBI-389883 I2D: score=2 STRING: ENSP00000288986
TXNDC17Q9BRA23, ENSP000002501014I2D: score=2 STRING: ENSP00000250101
ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
PREPP481473, ENSP000003581064I2D: score=1 STRING: ENSP00000358106
OXTRP305593, ENSP000003242704I2D: score=1 STRING: ENSP00000324270
About this table

Gene Ontology (GO): 5/48 biological process terms (GO ID links to tree view) (see all 48):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0001975response to amphetamine IEA--
GO:0002027regulation of heart rate IEA--
GO:0002125maternal aggressive behavior IEA--
GO:0006950response to stress ----
GO:0007165signal transduction TAS10218979

OXT for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

OXT for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Compounds for OXT available from Tocris Bioscience    About this table
CompoundAction CAS #
OxytocinInvolved in uterine contraction and lactation[50-56-6]
L-368,899 hydrochloride Potent, non-peptide oxytocin receptor antagonist [148927-60-0]
WAY 267464 dihydrochloridePotent non-peptide oxytocin receptor agonist[847375-16-0]
CarbetocinOxytocin analog[37025-55-1]
L-371,257 Potent and selective oxytocin receptor antagonist[162042-44-6]

UniProtKB/Swiss-Prot: NEU1_HUMAN, P01178
Pharmaceutical: Oxytocin is available under the names Pitocin (Parke-Davis) and Syntocinon (Sandoz). Used to
artificially speed or induce labor

1 HMDB Compound for OXT    About this table
CompoundSynonyms CAS #PubMed Ids
Oxytocin(Arg8)-Vasopressin (see all 22)50-56-6--

1 DrugBank Compound for OXT    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
OxytocinPitocin (see all 2)50-56-6targetbinder6687626 17016423 1486803

10/134 Novoseek inferred chemical compound relationships for OXT gene (see all 134)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
misoprostol 92.1 677 15229013 (9), 12789117 (9), 17321529 (8), 16753768 (8) (see all 99)
atosiban 90.4 123 10191468 (5), 14592588 (4), 8952002 (3), 18683742 (3) (see all 59)
carbetocin 87.1 90 19616358 (7), 19229549 (7), 16769107 (6), 17636798 (6) (see all 26)
methylergometrine 83.9 54 19628206 (5), 17091409 (4), 16634548 (3), 2245955 (2) (see all 32)
deaminooxytocin 83.5 7 8875590 (2), 1472646 (2), 9083475 (2), 8589250 (1)
syntometrine 83.3 36 11802188 (5), 10796180 (4), 7774741 (4), 11905429 (3) (see all 18)
13,14-dihydro-15-ketoprostaglandin f2alpha 82.7 33 1475375 (2), 9437586 (2), 7616495 (2), 9640273 (2) (see all 25)
syntocinon 82.4 20 12757361 (2), 10668163 (1), 1626855 (1), 15512541 (1) (see all 18)
ergonovine 81 119 20124553 (7), 8306013 (5), 17578351 (4), 17701671 (4) (see all 48)
cervidil 80.8 9 9822496 (5), 9322631 (1), 14749647 (1)

Search CenterWatch for drugs/clinical trials and news about OXT / NEU1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for OXT gene: 
NM_000915.3  

Unigene Cluster for OXT:

Oxytocin/neurophysin I prepropeptide
Hs.113216  [show with all ESTs]
Unigene Representative Sequence: NM_000915
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000217386(uc002wht.1)

miRNA
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Products:
     
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QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OXT
Clone
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                     Customized lentivirus expression plasmids for stable overexpression of OXT 
Primer
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SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OXT
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OXT
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OXT

Additional mRNA sequence: 

BC069144.1 BC101841.1 BC101843.1 M25650.1 M62611.1 X03173.1 

1 DOTS entry:

DT.306364 

7 AceView cDNA sequences:

NM_000915 M25650 AW270827 AW242780 BC069144 X03173 M62611 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OXT expression in normal human tissues (normalized intensities)      OXT embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCGGCCCCA
OXT Expression
About this image


OXT expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Brain (Nervous System)    fully expand to see all 9 entries
         Thalamus
         Olfactory Bulb   
 
 Ovary (Reproductive System)
         Secondary Oocyte Antral Follicle
 
 Gonad
         Secondary Oocyte Antral Follicle

 -- (Endocrine System)
         pituitary gland   

See OXT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OXT

SOURCE GeneReport for Unigene cluster: Hs.113216
    SABiosciences Expression via Pathway-Focused PCR Array including OXT: 
          Osmotic Stress in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for OXT
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OXT
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OXT
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXT

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for OXT gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Oxt1 , 5 oxytocin1, 5 86.93(n)1
87.2(a)1
  2 (63.24 cM)5
184291  NM_011025.31  NP_035155.11 
 1305761735 
chicken
(Gallus gallus)
Aves OXT1 oxytocin, prepro- (neurophysin I) 70.87(n)
68.91(a)
  768516  XM_001231491.2  XP_001231492.2 
zebrafish
(Danio rerio)
Actinopterygii itnp2 isotocin neurophysin 71.85(n)   352920  AY069956.1 


ENSEMBL Gene Tree for OXT (if available)
TreeFam Gene Tree for OXT (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for OXT gene
AVP2  
1 SIMAP similar gene for OXT using alignment to 1 protein entry:     NEU1_HUMAN:
AVP

OXT for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/87 SNPs in OXT are shown (see all 87)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs61330101,2
C,F,A,H--3050301(+) CCCTGA/GGCCAG 1 -- us2k114Minor allele frequency- N:0.02NS EA NA WA 884
rs37612461,2
C,F--3050335(+) GCTCTC/AGAGGA 1 -- us2k18Minor allele frequency- A:0.17NS EA NA CSA 661
rs37612481,2
C,F--3050393(+) GCAGGT/CGCTTT 1 -- us2k18Minor allele frequency- C:0.18NS EA NA CSA 663
rs787374531,2
F--3050429(+) TTTCCT/CTTCTT 1 -- us2k11Minor allele frequency- C:0.04WA 118
rs1411271371,2
--3050459(+) ACCTCC/TCCCAC 1 -- us2k10--------
rs1848771901,2
--3050488(+) CTTTTA/CATTAT 1 -- us2k10--------
rs114814161,2
C--3050529(+) AAAAA-/TAATTT 1 -- us2k1 trp30--------
rs20168991,2
C,A--3050531(+) AAAAAT/ATTTTT 1 -- us2k1 trp32Minor allele frequency- A:0.25WA NA 4
rs750551721,2
C--3050531(+) AAAAA-/TTTTTT 1 -- us2k10--------
rs61390021,2
A--3050537(+) TTTTTA/TTTTTT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for OXT (3052266 - 3053163 bp)

Structural Variations
     Database of Genomic Variants (DGV) 3 variations for OXT:    About this table     
Variant IDTypeSubtypePubMed ID
nsv833897CNV Loss17160897
nsv523746CNV Loss19592680
nsv912603CNV Gain21882294

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 167050    OMIM disorders: --

20/95 diseases for OXT (see all 95):    About MalaCards
erb's palsy    epignathus    sexual disorder    endometritis
gestational trophoblastic tumor    fetal macrosomia    petrositis    serotonin syndrome
neurohypophyseal diabetes insipidus    postpartum depression    dissecting aortic aneurysm    placenta accreta
oligohydramnios    meconium aspiration syndrome    myoma    polyhydramnios
asperger syndrome    morphine dependence    chorioamnionitis    diabetes insipidus

4 diseases from the University of Copenhagen DISEASES database for OXT:
Autistic disorder     Neurohypophyseal diabetes insipidus     Borderline personality disorder     Diabetes insipidus

OXT for disorders           About GeneDecksing


Congresses - knowledge worth sharing:  
Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

10/92 Novoseek inferred disease relationships for OXT gene (see all 92)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
postpartum hemorrhage 88.8 94 11802188 (4), 15103233 (4), 17578351 (4), 12179676 (4) (see all 60)
uterine atony 84.8 40 20238255 (3), 10076146 (3), 19733052 (2), 11530117 (2) (see all 26)
fetal distress 78 26 8233251 (3), 9141942 (1), 11730496 (1), 19034471 (1) (see all 23)
cephalopelvic disproportion 74.1 7 1445129 (1), 11080926 (1), 15770303 (1), 2145531 (1) (see all 7)
pregnancy prolonged 74 10 1892182 (2), 1398272 (2), 11928554 (1), 11883268 (1) (see all 8)
chorioamnionitis 72.6 38 1579312 (3), 9170488 (3), 10796160 (2), 10796161 (2) (see all 25)
labor prolonged 72.2 13 16949410 (2), 11883027 (1), 10368493 (1), 11120525 (1) (see all 12)
endometritis 63.5 11 8841214 (3), 9170488 (2), 19933542 (1), 17636608 (1) (see all 7)
isthmus uteri 61.6 3 16720280 (2)
fetal macrosomia 61 3 11958242 (1), 10190670 (1), 12596626 (1)

Genetic Association Database (GAD): OXT
Human Genome Epidemiology (HuGE) Navigator: OXT (21 documents)

Export disorders for OXT gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for OXT gene, integrated from 9 sources (see all 1935):
(articles sorted by number of sources associating them with OXT)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Polymorphism in the oxytocin promoter region in patie nts with lactase non-persistence is not related to symptoms. (PubMed id 19943975)1, 4, 9 Truedsson M....Ohlsson B. (2009)
  2. The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization. (PubMed id 1486803)1, 7, 9 Rao V.V....Hansmann I. (1992)
  3. Physiogenomic analysis of statin-treated patients: do main-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol? (PubMed id 20602615)1, 4 RuaA+o G....Wu A.H. (2010)
  4. No association between oxytocin or prolactin gene var iants and childhood-onset mood disorders. (PubMed id 20547007)1, 4 Strauss J.S....Kennedy J.L. (2010)
  5. Polymorphisms of candidate genes in Slovak autistic p atients. (PubMed id 20436377)1, 4 Kelemenova S....Ostatnikova D. (2010)
  6. Association study of 182 candidate genes in anorexia nervosa. (PubMed id 20468064)1, 4 Pinheiro A.P....Woodside D.B. (2010)
  7. Mutation analysis of oxytocin gene in individuals wit h adult separation anxiety. (PubMed id 19473710)1, 4 Costa B....Cassano G.B. (2009)
  8. A common variant in DRD3 receptor is associated with autism spectrum disorder. (PubMed id 19058789)1, 4 de Krom M....van Ree J.M. (2009)
  9. Determination of genetic predisposition to patent ductus arteriosus in preterm infants. (PubMed id 19336370)1, 4 Dagle J.M....Murray J.C. (2009)
  10. Genetical genomic determinants of alcohol consumption in rats and humans. (PubMed id 19874574)1, 4 Tabakoff B....Hoffman P.L. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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Disorders
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 5020 HGNC: 8528 AceView: OXT Ensembl:ENSG00000101405 euGenes: HUgn5020
ECgene: OXT H-InvDB: OXT

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for OXT Pharmacogenomics, SNPs, Pathways
Wikipedia http://en.wikipedia.org/wiki/Oxytocin

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for OXT gene:
Search GeneIP for patents involving OXT

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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