Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OXSR1 Gene

protein-coding   GIFtS: 61
GCID: GC03P038183

Oxidative Stress Responsive 1

(Previous name: oxidative-stress responsive 1)
(Previous symbol: OSR1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Oxidative Stress Responsive 11 2     EC 2.7.11.13 8
OSR11 2 3 5     Serine/Threonine-Protein Kinase OSR12
Oxidative-Stress Responsive 11 2     KIAA11013
Oxidative Stress-Responsive 1 Protein2 3     EC 2.7.118

External Ids:    HGNC: 85081   Entrez Gene: 99432   Ensembl: ENSG000001729397   OMIM: 6040465   UniProtKB: O957473   

Export aliases for OXSR1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OXSR1 Gene:
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases
in response to environmental stress, and may play a role in regulating the actin cytoskeleton. (provided by
RefSeq, Jul 2008)

GeneCards Summary for OXSR1 Gene: 
OXSR1 (oxidative stress responsive 1) is a protein-coding gene. Diseases associated with OXSR1 include pseudohypoaldosteronism, and hypertension. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is STRADB.

UniProtKB/Swiss-Prot: OXSR1_HUMAN, O95747
Function: Regulates downstream kinases in response to environmental stress. May also have a function in regulating
the actin cytoskeleton

Gene Wiki entry for OXSR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OXSR1 gene promoter:
         E2F-3a   E2F-4   E2F-5   SREBP-1c   E2F-2   E4BP4   SREBP-1b   E2F-1   E2F   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOXSR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OXSR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OXSR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.2   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p22.2

OXSR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OXSR1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P038183:  view genomic region     (about GC identifiers)

Start:
38,206,580 bp from pter      End:
38,296,979 bp from pter
Size:
90,400 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OXSR1_HUMAN, O95747 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase OSR1  
Size: 527 amino acids; 58022 Da
Cofactor: Magnesium
Subunit: Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and
SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the
cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAP97192.1; Type=Erroneous initiation; Sequence=BAA83053.2; Type=Frameshift;
Positions=63;
3 PDB 3D structures from and Proteopedia for OXSR1:
2V3S (3D)        2VWI (3D)        3DAK (3D)    
Secondary accessions: Q3LR53 Q7Z501 Q9UPQ1

Explore the universe of human proteins at neXtProt for OXSR1: NX_O95747

Explore proteomics data for OXSR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95747

  • 4/17 DME Specific Peptides for OXSR1 (O95747) (see all 17)
     RGYDFKA  KAGNILL  GITAIEL  SSALPWS 

    OXSR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OXSR1 Protein Expression
    REFSEQ proteins: NP_005100.1  
    ENSEMBL proteins: 
     ENSP00000415851   ENSP00000311713   ENSP00000398356  

    Human Recombinant Protein Products for OXSR1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for OXSR1
    OriGene Protein Over-expression Lysate for OXSR1
    OriGene MassSpec for OXSR1 
    OriGene Custom Protein Services for OXSR1
    GenScript Custom Purified and Recombinant Proteins Services for OXSR1
    Novus Biologicals OXSR1 Proteins
    Novus Biologicals OXSR1 Lysates
    Sino Biological Recombinant Protein for OXSR1
    Sino Biological Cell Lysate for OXSR1 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OXSR1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    OXSR1 for ontologies           About GeneDecksing



    OXSR1 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of OXSR1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for OXSR1  (OSR1)
    OriGene Antibodies for OXSR1
    OriGene Custom Antibody Services for OXSR1
    GenScript Custom Superior Antibodies Services for OXSR1
    Novus Biologicals OXSR1 Antibodies
    Abcam antibodies for OXSR1
    Cloud-Clone Corp. Antibodies for OXSR1 
    ThermoFisher Antibodies for OXSR1
    LSBio Antibodies in human, mouse, rat for OXSR1 

    Assay Products for OXSR1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OXSR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OXSR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OXSR1 
    Cloud-Clone Corp. CLIAs for OXSR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: oxidative-stress responsive 1 
    FRAY subfamily

    5 InterPro protein domains:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR024678 Kinase_OSR1/WNK_CCT

    Graphical View of Domain Structure for InterPro Entry O95747

    ProtoNet protein and cluster: O95747

    UniProtKB/Swiss-Prot: OXSR1_HUMAN, O95747
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    OXSR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OXSR1_HUMAN, O95747
    Function: Regulates downstream kinases in response to environmental stress. May also have a function in regulating
    the actin cytoskeleton
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: By autophosphorylation on threonine

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA14707132
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA14707132
    GO:0004713protein tyrosine kinase activity ----
    GO:0005515protein binding IPI17721439
         
    OXSR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OXSR1:
     Increased colony dispersion (i 

         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Oxsr1):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     renal/urinary system 

    OXSR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Oxsr1tm1.2Ssy for OXSR1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for OXSR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OXSR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OXSR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OXSR1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OXSR1
    8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate OXSR1 (see all 91):
    hsa-miR-199a-3p hsa-miR-200a hsa-miR-149 hsa-miR-298 hsa-miR-629 hsa-miR-3613-3p hsa-miR-3148 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidOXSR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OXSR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OXSR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OXSR1
    Sirion Biotech Customized adenovirus for overexpression of OXSR1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for OXSR1 (see all 7)
    OriGene ORF clones in mouse, rat for OXSR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OXSR1 (NM_005109)
    Sino Biological Human cDNA Clone for OXSR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OXSR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXSR1
    Sirion Biotech Customized lentivirus for stable overexpression of OXSR1 
                         Customized lentivirus expression plasmids for stable overexpression of OXSR1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OXSR1
    Search LifeMap BioReagents cell lines for OXSR1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXSR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for OXSR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cytoskeletal Signaling
    Cytoskeletal Signaling
    2Diuretics Pathway, Pharmacodynamics
    Diuretics Pathway, Pharmacodynamics

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for OXSR1
        Cytoskeletal Signaling


    1 PharmGKB Pathway for OXSR1
        Diuretics Pathway, Pharmacodynamics


    OXSR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OXSR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/794 Interacting proteins for OXSR1 (O957472, 3 ENSP000003117134) via UniProtKB, MINT, STRING, and/or I2D (see all 794)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WNK4Q96J922, 3, ENSP000002469144MINT-5207699 MINT-5207631 MINT-5207540 MINT-5207597 MINT-5207682 MINT-5207580 MINT-5207648 MINT-5207716 MINT-5207665 MINT-5207614 MINT-5207558 I2D: score=1 STRING: ENSP00000246914
    PAK1Q131532, 3, ENSP000002785684MINT-7945693 I2D: score=2 STRING: ENSP00000278568
    UBA5Q9GZZ92, 3MINT-7947479 MINT-7945693 I2D: score=1 
    CAB39Q9Y3762, 3, ENSP000002584184MINT-8186566 MINT-8186657 MINT-8186672 I2D: score=1 STRING: ENSP00000258418
    SLC12A2P550112, 3, ENSP000002624614MINT-5207773 MINT-5207788 I2D: score=4 STRING: ENSP00000262461
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA14707132
    GO:0006979response to oxidative stress IEA--
    GO:0007243intracellular protein kinase cascade IDA14707132

    OXSR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OXSR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OXSR1

    4 HMDB Compounds for OXSR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    ChlorineCl2 (see all 13)16887-00-6--
    MagnesiumMagnesium (see all 2)7439-95-4--

    6 Novoseek inferred chemical compound relationships for OXSR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 74.1 9 16173916 (1), 16734747 (1), 16669787 (1), 17190791 (1) (see all 9)
    thiazide 67.5 1 18270262 (1)
    lysine 57.1 5 16832045 (1), 16669787 (1), 17223794 (1), 18277153 (1)
    chloride 45.3 3 16734747 (1), 16669787 (1)
    threonine 27.7 2 16173916 (1), 16734747 (1)
    serine 25.4 10 16263722 (2), 16083423 (1), 16734747 (1)

    Search CenterWatch for drugs/clinical trials and news about OXSR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OXSR1 gene: 
    NM_005109.2  

    Unigene Cluster for OXSR1:

    Oxidative-stress responsive 1
    Hs.475970  [show with all ESTs]
    Unigene Representative Sequence: NM_005109
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492714 ENST00000446845 ENST00000311806(uc003chy.3 uc010hhb.3)
    ENST00000426620(uc010hha.1) ENST00000483695 ENST00000467900
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OXSR1
    8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate OXSR1 (see all 91):
    hsa-miR-199a-3p hsa-miR-200a hsa-miR-149 hsa-miR-298 hsa-miR-629 hsa-miR-3613-3p hsa-miR-3148 hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmidOXSR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OXSR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OXSR1
    Clone
    Products:
         
    OriGene clones in human, mouse for OXSR1 (see all 7)
    OriGene ORF clones in mouse, rat for OXSR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OXSR1 (NM_005109)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OXSR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXSR1
    Sirion Biotech Customized lentivirus for stable overexpression of OXSR1 
                         Customized lentivirus expression plasmids for stable overexpression of OXSR1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for OXSR1
    OriGene qSTAR qPCR primer pairs in human, mouse for OXSR1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OXSR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OXSR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OXSR1

    Additional mRNA sequence: 

    AB017642.1 AB029024.1 AF087893.1 AK309634.1 BC008726.2 EF491806.1 EF491821.1 

    7 DOTS entries:

    DT.452024  DT.120847852  DT.75191766  DT.95231885  DT.120847845  DT.75103557  DT.95284602 

    24/183 AceView cDNA sequences (see all 183):

    BM550870 BM800036 BC008726 BE302407 AI628009 BQ011845 BE502111 AA297759 
    Z43501 BE891283 AA988954 AA100484 BM997092 AI290901 BM549200 CD672858 
    BU157630 BX102083 CA430242 NM_005109 AA099174 AI784235 CD521087 BE908377 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OXSR1 expression in normal human tissues (normalized intensities)      OXSR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCTTCAT
    OXSR1 Expression
    About this image


    OXSR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Tonsil (Hematopoietic System)    fully expand to see all 3 entries
             tonsil ; squamous epithelial cells   

    See OXSR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OXSR1

    SOURCE GeneReport for Unigene cluster: Hs.475970

    UniProtKB/Swiss-Prot: OXSR1_HUMAN, O95747
    Tissue specificity: Ubiquitously expressed in all tissue examined

        SABiosciences Expression via Pathway-Focused PCR Array including OXSR1: 
              Oxidative Stress in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for OXSR1
    OriGene qSTAR qPCR primer pairs in human, mouse for OXSR1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OXSR1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OXSR1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OXSR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXSR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OXSR1 gene from 10/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oxsr11 , 5 oxidative-stress responsive 11, 5 90.51(n)1
    95.83(a)1
      9 (71.33 cM)5
    1087371  NM_133985.21  NP_598746.21 
     1192384325 
    chicken
    (Gallus gallus)
    Aves OXSR11 oxidative-stress responsive 1 81.4(n)
    87.86(a)
      420421  XM_418527.1  XP_418527.1 
    lizard
    (Anolis carolinensis)
    Reptilia OXSR16
    Uncharacterized protein
    87(a)
    1 ↔ 1
    6(783388-871142)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.123462 Xenopus laevis transcribed sequence with moderate similarity more 78.23(n)    CF288103.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc554942 similar to oxidative-stress responsive 1 76.12(n)   394150  BC044183.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fray1 frayed 56.73(n)
    58.24(a)
      44233  NM_169823.1  NP_732352.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gck-31 Protein GCK-3 57.3(n)
    57.23(a)
      190400  NM_075116.3  NP_507517.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes SPS16
    Putative protein serine/threonine kinase expressed...
    29(a)
    1 → many
    IV(1485566-1487038)
    soybean
    (Glycine max)
    eudicotyledons BM527293.12   -- 72.98(n)    BM527293.1 
    rice
    (Oryza sativa)
    Liliopsida Os.186002 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.03(n)    AK065283.1 


    ENSEMBL Gene Tree for OXSR1 (if available)
    TreeFam Gene Tree for OXSR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OXSR1 gene
    STRADB2  STRADA2  STK392  
    18/35 SIMAP similar genes for OXSR1 using alignment to 4 protein entries:     OXSR1_HUMAN (see all proteins) (see all similar genes):
    STK39    PAK2    MAPK8    PAK1    STK11    MST4
    MAP4K5    STRADA    MYO3A    NEK6    MAP4K3    PAK4
    STK25    CAMK1    STK4    MARK4    NEK7    DKFZp564L2416

    OXSR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1654 SNPs in OXSR1 are shown (see all 1654)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0409694
    A metastatic melanoma sample4--see VAR_0409692 P S mis40--------
    rs1850527731,2
    --38205359(+) GTCTAC/TGTGCC 1 -- us2k10--------
    rs341773351,2
    C--38205521(+) AGGGGTTCA/-  
            
    TTAAC
    1 -- us2k15Minor allele frequency- -:0.00NS 190
    rs286319551,2
    C,F--38205733(+) TCACTG/ACAACC 1 -- us2k1 tfbs37Minor allele frequency- A:0.03NS WA 308
    rs1895194971,2
    --38206158(+) AACCCC/GCAAAT 1 -- us2k10--------
    rs357183801,2
    C,F--38206223(+) GACAAC/TCTCCC 1 -- us2k15Minor allele frequency- T:0.01NS 186
    rs350718121,2
    C,F--38206356(+) CCTTG-/AAAAAA 1 -- us2k15Minor allele frequency- A:0.02NS 186
    rs1870341671,2
    --38206453(+) TACCCC/GACCCA 1 -- us2k10--------
    rs351180991,2
    C,F--38206562(+) ACGAGC/GGCGGT 1 -- us2k16Minor allele frequency- G:0.02NS EA 280
    rs344666981,2
    C,F--38206702(+) AATGCG/CACGAC 1 -- us2k16Minor allele frequency- C:0.02NS NA 286

    HapMap Linkage Disequilibrium report for OXSR1 (38206580 - 38296979 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OXSR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3768CNV Insertion18451855
    esv274896CNV Loss21479260

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing OXSR1
    DNA2.0 Custom Variant and Variant Library Synthesis for OXSR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604046    OMIM disorders: --

    3 diseases for OXSR1:    About MalaCards
    pseudohypoaldosteronism    hypertension    schizophrenia


    OXSR1 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: OXSR1 (1 document)

    Export disorders for OXSR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OXSR1 gene, integrated from 9 sources (see all 54):
    (articles sorted by number of sources associating them with OXSR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3. (PubMed id 10083736)1, 2, 3 Tamari M.... Nakamura Y. (1999)
    2. Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. (PubMed id 16389068)1, 2 Cusick J.K.... Shu H.-B. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. (PubMed id 14707132)1, 2 Chen W.... Cobb M.H. (2004)
    6. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    7. Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. (PubMed id 16669787)1, 9 Vitari A.C....Alessi D.R. (2006)
    8. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. (PubMed id 16263722)1, 9 Moriguchi T....Shibuya H. (2005)
    9. WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. (PubMed id 16832045)1, 9 Anselmo A.N....Cobb M.H. (2006)
    10. Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. (PubMed id 18270262)1, 9 Richardson C....Alessi D.R. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9943 HGNC: 8508 AceView: OSR1 Ensembl:ENSG00000172939 euGenes: HUgn9943
    ECgene: OXSR1 H-InvDB: OXSR1

    (According to HUGE)
    About This Section
    HUGE: KIAA1101

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OXSR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OXSR1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/oxsr1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OXSR1 gene:
    Search GeneIP for patents involving OXSR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of OXSR1
     Browse Kits and Assays available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for OXSR1   OriGene RNAi products in human, mouse, rat for OXSR1  
     OriGene qPCR primer pairs and template standards for OXSR1   OriGene Protein Over-expression Lysate for OXSR1  
     OriGene MassSpec something-or-other for OXSR1   OriGene clones in human, mouse for OXSR1  
     OriGene qSTAR qPCR primer pairs in human, mouse for OXSR1   OriGene Purified Protein for OXSR1  
     OriGene ORF clones in mouse, rat for OXSR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OXSR1   OriGene Custom Protein Services for OXSR1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OXSR1
     QIAGEN SeqTarget long-range PCR primers for resequencing OXSR1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OXSR1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OXSR1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OXSR1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OXSR1
     GenScript Custom Purified and Recombinant Proteins Services for OXSR1 GenScript cDNA clones with any tag delivered in your preferred vector for OXSR1
     GenScript Custom Assay Services for OXSR1 GenScript Custom Superior Antibodies Services for OXSR1
     GenScript Custom overexpressing Cell Line Services for OXSR1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Antibodies & Assays for OXSR1  (OSR1)

     Regulatory tfbs in OXSR1 promoter
     Search Chromatin IP Primers for OXSR1
     RT2 qPCR Primer Assay in human, mouse, rat OXSR1
     GNC Network for OXSR1
     SABiosciences PCR Arrays including human, mouse, rat OXSR1
     Search Tocris compounds for OXSR1
     Proteins and Antibodies for OXSR1
     Cell Lysates for OXSR1
     cDNA Clones for OXSR1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     OXSR1 antibodies
     OXSR1 proteins
     OXSR1 lysates
     Antibodies for OXSR1
     See all of Abcam's Antibodies, Kits and Proteins for OXSR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for OXSR1
     Antibodies for OXSR1
     ELISAs for OXSR1
     CLIAs for OXSR1
     Search LifeMap BioReagents cell lines for OXSR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXSR1
     SwitchGear 3'UTR luciferase reporter plasmids for OXSR1
     SwitchGear Promoter luciferase reporter plasmids for OXSR1
     ThermoFisher Antibodies for OXSR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXSR1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for OXSR1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OXSR1
    Customized:
     lentivirus for stable overexpression of OXSR1
     lentivirus expression plasmids for stable overexpression of OXSR1
     adenovirus for overexpression of OXSR1
     LSBio Antibodies in human, mouse, rat for OXSR1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OXSR1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4