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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OXSR1 Gene

protein-coding   GIFtS: 56
GCID: GC03P038183

oxidative-stress responsive 1


(Previous symbol: OSR1)
 Explore 3 diseases affiliated with
OXSR1 via our new
 Human Malady Compendium 
Biological research products
for OXSR1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Oxidative-Stress Responsive 11 2     EC 2.7.11.13 8
OSR11 2 3 5     Serine/Threonine-Protein Kinase OSR12
KIAA11011 3     EC 2.7.118
Oxidative Stress-Responsive 1 Protein2 3     

External Ids:    HGNC: 85081   Entrez Gene: 99432   Ensembl: ENSG000001729397   OMIM: 6040465   UniProtKB: O957473   

Export aliases for OXSR1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OXSR1:
The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in
response to environmental stress, and may play a role in regulating the actin cytoskeleton. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: OXSR1_HUMAN, O95747
Function: Regulates downstream kinases in response to environmental stress. May also have a function in regulating the
actin cytoskeleton

Gene Wiki entry for OXSR1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OXSR1 gene promoter:
         E2F-3a   E2F-4   E2F-5   SREBP-1c   E2F-2   E4BP4   SREBP-1b   E2F-1   E2F   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOXSR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OXSR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OXSR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.2   Ensembl cytogenetic band:  3p22.2   HGNC cytogenetic band: 3p22.2

OXSR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OXSR1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P038183:  view genomic region     (about GC identifiers)

Start:
38,206,580 bp from pter      End:
38,296,979 bp from pter
Size:
90,400 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OXSR1_HUMAN, O95747 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase OSR1  
Size: 527 amino acids; 58022 Da
Cofactor: Magnesium
Subunit: Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and
SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular
response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT
Subcellular location: Cytoplasm
Sequence caution: Sequence=AAP97192.1; Type=Erroneous initiation; Sequence=BAA83053.2; Type=Frameshift; Positions=63;
3 PDB 3D structures from and Proteopedia for OXSR1:
2V3S (3D)        2VWI (3D)        3DAK (3D)    
Secondary accessions: Q3LR53 Q7Z501 Q9UPQ1

Explore the universe of human proteins at neXtProt for OXSR1: NX_O95747

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95747

  • 4/17 DME Specific Peptides for OXSR1 (O95747) (see all 17)
     RGYDFKA  KAGNILL  GITAIEL  SSALPWS 

    OXSR1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005100.1  
    ENSEMBL proteins: 
     ENSP00000415851   ENSP00000311713   ENSP00000398356  

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    Uscn Proteins for OXSR1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--


    OXSR1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for OXSR1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    OXSR1 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR024678 Kinase_OSR1/WNK_CCT

    Graphical View of Domain Structure for InterPro Entry O95747

    ProtoNet protein and cluster: O95747

    UniProtKB/Swiss-Prot: OXSR1_HUMAN, O95747
    Similarity: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily
    Similarity: Contains 1 protein kinase domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: OXSR1_HUMAN, O95747
    Function: Regulates downstream kinases in response to environmental stress. May also have a function in regulating the
    actin cytoskeleton
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: By autophosphorylation on threonine

    Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

    miRNA
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    hsa-miR-199a-3p hsa-miR-200a hsa-miR-149 hsa-miR-298 hsa-miR-629 hsa-miR-3613-3p hsa-miR-3148 hsa-miR-92b
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000287magnesium ion binding IDA14707132
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity IDA14707132
    GO:0005515protein binding ----
    GO:0005524ATP binding IDA14707132


    OXSR1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for OXSR1:
     Increased colony dispersion (i 

    Animal Models:
         Mouse knock-out Oxsr1tm1.2Ssy for OXSR1
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Oxsr1):
     cardiovascular system  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     renal/urinary system 

    OXSR1 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytoskeletal Signaling
    Cytoskeletal Signaling1.00
    2Diuretics Pathway, Pharmacodynamics
    Diuretics Pathway, Pharmacodynamics1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for OXSR1
        Cytoskeletal Signaling

    1 PharmGKB Pathway for OXSR1
        Diuretics Pathway, Pharmacodynamics


    OXSR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OXSR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/757 Interacting proteins for OXSR1 (O957472, 3 ENSP000003117134) via UniProtKB, MINT, STRING, and/or I2D (see all 757)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    WNK4Q96J922, 3, ENSP000002469144MINT-5207699 MINT-5207631 MINT-5207540 MINT-5207597 MINT-5207682 MINT-5207580 MINT-5207648 MINT-5207716 MINT-5207665 MINT-5207614 MINT-5207558 I2D: score=1 STRING: ENSP00000246914
    PAK1Q131532, 3, ENSP000002785684MINT-7945693 I2D: score=2 STRING: ENSP00000278568
    UBA5Q9GZZ92, 3MINT-7947479 MINT-7945693 I2D: score=1 
    CAB39Q9Y3762, 3, ENSP000002584184MINT-8186566 MINT-8186657 MINT-8186672 I2D: score=1 STRING: ENSP00000258418
    SLC12A2P550112, 3, ENSP000002624614MINT-5207773 MINT-5207788 I2D: score=4 STRING: ENSP00000262461
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA14707132
    GO:0006979response to oxidative stress IEA--
    GO:0007243intracellular protein kinase cascade IDA14707132


    OXSR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    OXSR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OXSR1

    4 HMDB Compounds for OXSR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    ChlorineCl2 (see all 13)16887-00-6--
    MagnesiumMagnesium (see all 2)7439-95-4--
    6 Novoseek chemical compound relationships for OXSR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    proline 74.1 9 16173916 (1), 16734747 (1), 16669787 (1), 17190791 (1) (see all 9)
    thiazide 67.5 1 18270262 (1)
    lysine 57.1 5 16832045 (1), 16669787 (1), 17223794 (1), 18277153 (1)
    chloride 45.3 3 16734747 (1), 16669787 (1)
    threonine 27.7 2 16173916 (1), 16734747 (1)
    serine 25.4 10 16263722 (2), 16083423 (1), 16734747 (1)

    Search CenterWatch for drugs/clinical trials and news about OXSR1 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OXSR1 gene: 
    NM_005109.2  

    Unigene Cluster for OXSR1:

    Oxidative-stress responsive 1
    Hs.475970  [show with all ESTs]
    Unigene Representative Sequence: NM_005109
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492714 ENST00000446845 ENST00000311806(uc003chy.3 uc010hhb.3)
    ENST00000426620(uc010hha.1) ENST00000483695 ENST00000467900

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    hsa-miR-199a-3p hsa-miR-200a hsa-miR-149 hsa-miR-298 hsa-miR-629 hsa-miR-3613-3p hsa-miR-3148 hsa-miR-92b
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    Additional cDNA sequence: 

    AB017642.1 AB029024.1 AF087893.1 AK309634.1 BC008726.2 EF491806.1 EF491821.1 

    7 DOTS entries:

    DT.452024  DT.120847852  DT.75191766  DT.95231885  DT.120847845  DT.75103557  DT.95284602 

    24/183 AceView cDNA sequences (see all 183):

    AB029024 AA237059 BM479021 AA988954 AA100484 AI290901 BM549200 BM997092 
    BE908377 CA423243 BQ717345 T35193 BM550870 BC008726 BM800036 BQ011845 
    AI628009 BE302407 AI088558 BF591899 AB017642 BQ223736 AW167178 Z43501 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OXSR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTCTTCAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See OXSR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OXSR1

    SOURCE GeneReport for Unigene cluster: Hs.475970

    UniProtKB/Swiss-Prot: OXSR1_HUMAN, O95747
    Tissue specificity: Ubiquitously expressed in all tissue examined

        SABiosciences Expression via Pathway-Focused PCR Array including OXSR1: 
              Oxidative Stress in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXSR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for OXSR1 gene from 8/30 species (see all 30)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves OXSR11 oxidative-stress responsive 1 81.4(n)
    87.86(a)
      420421  XM_418527.1  XP_418527.1 
    lizard
    (Anolis carolinensis)
    Reptilia OXSR16
    --
    88(a)
    1 ↔ 1
    6(787922-870533)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.123462 Xenopus laevis transcribed sequence with moderate similarity more 78.23(n)    CF288103.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc554942 similar to oxidative-stress responsive 1 76.12(n)   394150  BC044183.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta fray1 frayed 56.73(n)
    58.24(a)
      44233  NM_169823.1  NP_732352.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gck-31 Protein GCK-3 57.3(n)
    57.23(a)
      190400  NM_075116.3  NP_507517.2 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT1G237006
    AT4G144806
    (see all 7)
    protein kinase family protein
    (see all 7)
    30(a)
    27(a)
    (see all 7)
    many ↔ many
    many ↔ many
    (see all 7)
    1(8379454-8381965)
    4(8330081-8331544)
    rice
    (Oryza sativa)
    Liliopsida Os.186002 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 71.03(n)    AK065283.1 


    ENSEMBL Gene Tree for OXSR1 (if available)
    TreeFam Gene Tree for OXSR1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OXSR1 gene
    STRADB2  STRADA2  STK392  
    18/36 SIMAP similar genes for OXSR1 using alignment to 4 protein entries:     OXSR1_HUMAN (see all proteins) (see all similar genes):
    STK39    PAK2    MAPK8    PAK1    STK11    MST4
    MAP4K5    STRADA    MYO3A    NEK6    MAP4K3    PAK4
    STK25    CAMK1    STK4    MARK4    NEK7    DKFZp564L2416

    OXSR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1377 NCBI SNPs in OXSR1 are shown (see all 1377    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1850527731,2
    --38205359(+) GTCTAC/TGTGCC 1 -- us2k10--------
    rs1434947331,2
    C,--38205521(+) AGGGG-/TTCA  
            
    TTAAC
    1 -- us2k10--------
    rs286319551,2
    C,F,--38205733(+) TCACTG/ACAACC 1 -- us2k1 tfbs37Minor allele frequency- A:0.03NS WA 308
    rs1895194971,2
    --38206158(+) AACCCC/GCAAAT 1 -- us2k10--------
    rs357183801,2
    C,F,--38206223(+) GACAAC/TCTCCC 1 -- us2k15Minor allele frequency- T:0.01NS 186
    rs350718121,2
    C,F,--38206356(+) CCTTG-/AAAAAA 1 -- us2k15Minor allele frequency- A:0.02NS 186
    rs1870341671,2
    --38206453(+) TACCCC/GACCCA 1 -- us2k10--------
    rs351180991,2
    C,--38206562(+) ACGAGC/GGCGGT 1 -- us2k16Minor allele frequency- G:0.02NS EA 280
    rs344666981,2
    C,F,--38206702(+) AATGCG/CACGAC 1 -- us2k16Minor allele frequency- C:0.02NS NA 286
    rs126304301,2
    C,H--38206853(+) TCTACC/TTAAGC 1 -- us2k14Minor allele frequency- T:0.00NS EA 412

    HapMap Linkage Disequilibrium report for OXSR1 (38206580 - 38296979 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for OXSR1: --

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OXSR1 for disorders           About GeneDecksing

    OMIM gene information: 604046    OMIM disorders: --

    3 diseases for OXSR1:    About MalaCards
    pseudohypoaldosteronism    hypertension    schizophrenia

    Human Genome Epidemiology (HuGE) Navigator: OXSR1 (1 document)

    Export disorders for OXSR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OXSR1 gene, integrated from 9 sources (see all 51):
    (articles sorted by number of sources associating them with OXSR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3. (PubMed id 10083736)1, 2, 3 Tamari M.... Nakamura Y. (1999)
    2. Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. (PubMed id 16389068)1, 2 Cusick J.K.... Shu H.-B. (2006)
    3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Characterization of OSR1, a member of the mammalian Ste20p/germinal center kinase subfamily. (PubMed id 14707132)1, 2 Chen W.... Cobb M.H. (2004)
    6. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10470851)1, 2 Kikuno R....Ohara O. (1999)
    7. Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. (PubMed id 16669787)1, 9 Vitari A.C....Alessi D.R. (2006)
    8. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. (PubMed id 16263722)1, 9 Moriguchi T....Shibuya H. (2005)
    9. WNK1 and OSR1 regulate the Na+, K+, 2Cl- cotransporter in HeLa cells. (PubMed id 16832045)1, 9 Anselmo A.N....Cobb M.H. (2006)
    10. Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. (PubMed id 18270262)1, 9 Richardson C....Alessi D.R. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9943 HGNC: 8508 AceView: OSR1 Ensembl:ENSG00000172939 euGenes: HUgn9943
    ECgene: OXSR1 H-InvDB: OXSR1

    (According to HUGE)
    About This Section
    HUGE: KIAA1101

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OXSR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for OXSR1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/oxsr1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OXSR1 gene:
    Search GeneIP for patents involving OXSR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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