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Aliases for OXSR1 Gene

Aliases for OXSR1 Gene

  • Oxidative Stress Responsive 1 2 3
  • Oxidative Stress-Responsive 1 Protein 3 4
  • Oxidative-Stress Responsive 1 2 3
  • EC 2.7.11.1 4 63
  • OSR1 3 4
  • EC 2.7.11 63
  • KIAA1101 4

External Ids for OXSR1 Gene

Previous HGNC Symbols for OXSR1 Gene

  • OSR1

Summaries for OXSR1 Gene

Entrez Gene Summary for OXSR1 Gene

  • The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]

GeneCards Summary for OXSR1 Gene

OXSR1 (Oxidative Stress Responsive 1) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Diuretics Pathway, Pharmacodynamics. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is STK39.

UniProtKB/Swiss-Prot for OXSR1 Gene

  • Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.

Gene Wiki entry for OXSR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXSR1 Gene

Genomics for OXSR1 Gene

Regulatory Elements for OXSR1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OXSR1 Gene

Chromosome:
3
Start:
38,165,089 bp from pter
End:
38,255,488 bp from pter
Size:
90,400 bases
Orientation:
Plus strand

Genomic View for OXSR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OXSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXSR1 Gene

Proteins for OXSR1 Gene

  • Protein details for OXSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95747-OXSR1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase OSR1
    Protein Accession:
    O95747
    Secondary Accessions:
    • Q3LR53
    • Q7Z501
    • Q9UPQ1

    Protein attributes for OXSR1 Gene

    Size:
    527 amino acids
    Molecular mass:
    58022 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT.
    SequenceCaution:
    • Sequence=AAP97192.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA83053.2; Type=Frameshift; Positions=63; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OXSR1 Gene

neXtProt entry for OXSR1 Gene

Proteomics data for OXSR1 Gene at MOPED

Post-translational modifications for OXSR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OXSR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for OXSR1 (OSR1)

Domains & Families for OXSR1 Gene

Gene Families for OXSR1 Gene

Suggested Antigen Peptide Sequences for OXSR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95747

UniProtKB/Swiss-Prot:

OXSR1_HUMAN :
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.
genes like me logo Genes that share domains with OXSR1: view

Function for OXSR1 Gene

Molecular function for OXSR1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
By autophosphorylation on threonine.
UniProtKB/Swiss-Prot Function:
Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.

Enzyme Numbers (IUBMB) for OXSR1 Gene

Gene Ontology (GO) - Molecular Function for OXSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 14707132
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 14707132
GO:0004702 receptor signaling protein serine/threonine kinase activity --
GO:0005515 protein binding IPI 17721439
genes like me logo Genes that share ontologies with OXSR1: view
genes like me logo Genes that share phenotypes with OXSR1: view

Animal Models for OXSR1 Gene

MGI Knock Outs for OXSR1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OXSR1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for OXSR1 Gene

Localization for OXSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXSR1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OXSR1 Gene COMPARTMENTS Subcellular localization image for OXSR1 gene
Compartment Confidence
extracellular 5
cytosol 2

Gene Ontology (GO) - Cellular Components for OXSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with OXSR1: view

Pathways & Interactions for OXSR1 Gene

genes like me logo Genes that share pathways with OXSR1: view

Pathways by source for OXSR1 Gene

1 Cell Signaling Technology pathway for OXSR1 Gene
1 PharmGKB pathway for OXSR1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Oxidative Stress in human,mouse,rat

SIGNOR curated interactions for OXSR1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for OXSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 14707132
GO:0006979 response to oxidative stress IEA --
GO:0007346 regulation of mitotic cell cycle IBA --
GO:0018107 peptidyl-threonine phosphorylation IDA 24393035
GO:0023014 signal transduction by protein phosphorylation IBA --
genes like me logo Genes that share ontologies with OXSR1: view

Drugs & Compounds for OXSR1 Gene

(6) Drugs for OXSR1 Gene - From: HMDB and NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Magnesium Nutra 0
lysine Nutra 70
proline Nutra 20
serine Nutra 420

(4) Additional Compounds for OXSR1 Gene - From: HMDB and NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
Chloride ion
  • Bertholite
  • Chloor
  • Chlor
  • Chlore
  • Chloride
16887-00-6
chloride
thiazide
genes like me logo Genes that share compounds with OXSR1: view

Transcripts for OXSR1 Gene

Unigene Clusters for OXSR1 Gene

Oxidative-stress responsive 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OXSR1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OXSR1 Gene

No ASD Table

Relevant External Links for OXSR1 Gene

GeneLoc Exon Structure for
OXSR1
ECgene alternative splicing isoforms for
OXSR1

Expression for OXSR1 Gene

mRNA expression in normal human tissues for OXSR1 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for OXSR1 Gene



SOURCE GeneReport for Unigene cluster for OXSR1 Gene Hs.475970

mRNA Expression by UniProt/SwissProt for OXSR1 Gene

O95747-OXSR1_HUMAN
Tissue specificity: Ubiquitously expressed in all tissue examined.
genes like me logo Genes that share expression patterns with OXSR1: view

Protein tissue co-expression partners for OXSR1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein differential expression in normal tissues for OXSR1 Gene

Orthologs for OXSR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OXSR1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OXSR1 35
  • 93.04 (n)
  • 97.15 (a)
OXSR1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OXSR1 35
  • 93.99 (n)
  • 97.15 (a)
OXSR1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oxsr1 35
  • 90.51 (n)
  • 95.83 (a)
Oxsr1 16
Oxsr1 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OXSR1 35
  • 99.75 (n)
  • 99.62 (a)
OXSR1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oxsr1 35
  • 90.58 (n)
  • 95.83 (a)
oppossum
(Monodelphis domestica)
Mammalia OXSR1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OXSR1 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves OXSR1 35
  • 81.4 (n)
  • 87.86 (a)
OXSR1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OXSR1 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia stk39 35
  • 75.37 (n)
  • 87.24 (a)
Str.5309 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.12346 35
zebrafish
(Danio rerio)
Actinopterygii zgc55494 35
oxsr1a 36
  • 82 (a)
OneToMany
oxsr1b 36
  • 82 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006715 35
  • 54.04 (n)
  • 58.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta fray 35
  • 56.8 (n)
  • 57.84 (a)
fray 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gck-3 35
  • 58.97 (n)
  • 59.04 (a)
gck-3 36
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLA4 36
  • 13 (a)
ManyToMany
SKM1 36
  • 16 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.18600 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5075 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9457 36
  • 61 (a)
OneToMany
Species with no ortholog for OXSR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OXSR1 Gene

ENSEMBL:
Gene Tree for OXSR1 (if available)
TreeFam:
Gene Tree for OXSR1 (if available)

Paralogs for OXSR1 Gene

Paralogs for OXSR1 Gene

genes like me logo Genes that share paralogs with OXSR1: view

Variants for OXSR1 Gene

Sequence variations from dbSNP and Humsavar for OXSR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs128404 -- 38,235,073(+) actta(C/G)gactg intron-variant
rs149586 -- 38,235,114(+) ctaaa(A/G)agtat intron-variant
rs149822 -- 38,233,043(+) tgaca(A/G)tctta intron-variant
rs149823 -- 38,224,785(+) TACAG(A/G)AAATT intron-variant
rs149824 -- 38,223,985(+) TCTTT(A/T)AAttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OXSR1 Gene

Variant ID Type Subtype PubMed ID
esv274896 CNV Loss 21479260
nsv3768 CNV Insertion 18451855

Variation tolerance for OXSR1 Gene

Residual Variation Intolerance Score: 21.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.02; 84.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OXSR1 Gene

HapMap Linkage Disequilibrium report
OXSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXSR1 Gene

Disorders for OXSR1 Gene

Relevant External Links for OXSR1

Human Genome Epidemiology (HuGE) Navigator
OXSR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OXSR1
genes like me logo Genes that share disorders with OXSR1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OXSR1 Gene

Publications for OXSR1 Gene

  1. Molecular components of signal amplification in olfactory sensory cilia. (PMID: 20231443) Hengl T. … MAPhrlen F. (Proc. Natl. Acad. Sci. U.S.A. 2010) 23 67
  2. Characterization of the kinase activity of a WNK4 protein complex. (PMID: 19587141) Ahlstrom R. … Yu A.S. (Am. J. Physiol. Renal Physiol. 2009) 23 67
  3. SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells. (PMID: 18092945) Delpire E. … Gagnon K.B. (Biochem. J. 2008) 23 67
  4. Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. (PMID: 18270262) Richardson C. … Alessi D.R. (J. Cell. Sci. 2008) 23 67
  5. Cotransporters, WNKs and hypertension: an update. (PMID: 18277153) Flatman P.W. (Curr. Opin. Nephrol. Hypertens. 2008) 23 67

Products for OXSR1 Gene

Sources for OXSR1 Gene

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