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Aliases for OXSR1 Gene

Aliases for OXSR1 Gene

  • Oxidative Stress Responsive 1 2 3
  • OSR1 3 4 6
  • Oxidative Stress-Responsive 1 Protein 3 4
  • Oxidative-Stress Responsive 1 2 3
  • EC 2.7.11.1 4 63
  • Serine/Threonine-Protein Kinase OSR1 3
  • EC 2.7.11 63
  • KIAA1101 4

External Ids for OXSR1 Gene

Previous Symbols for OXSR1 Gene

  • OSR1

Summaries for OXSR1 Gene

Entrez Gene Summary for OXSR1 Gene

  • The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]

GeneCards Summary for OXSR1 Gene

OXSR1 (Oxidative Stress Responsive 1) is a Protein Coding gene. Among its related pathways are Cytoskeletal Signaling and Diuretics Pathway, Pharmacodynamics. GO annotations related to this gene include protein serine/threonine kinase activity and magnesium ion binding. An important paralog of this gene is STK39.

UniProtKB/Swiss-Prot for OXSR1 Gene

  • Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.

Gene Wiki entry for OXSR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXSR1 Gene

Genomics for OXSR1 Gene

Genomic Location for OXSR1 Gene

Start:
38,165,089 bp from pter
End:
38,255,488 bp from pter
Size:
90,400 bases
Orientation:
Plus strand

Genomic View for OXSR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OXSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXSR1 Gene

Regulatory Elements for OXSR1 Gene

Proteins for OXSR1 Gene

  • Protein details for OXSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95747-OXSR1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase OSR1
    Protein Accession:
    O95747
    Secondary Accessions:
    • Q3LR53
    • Q7Z501
    • Q9UPQ1

    Protein attributes for OXSR1 Gene

    Size:
    527 amino acids
    Molecular mass:
    58022 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds to and phosphorylates PAK1. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. Binds to and phosphorylates RELL1, RELL2 AND RELT.
    SequenceCaution:
    • Sequence=AAP97192.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA83053.2; Type=Frameshift; Positions=63; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for OXSR1 Gene

neXtProt entry for OXSR1 Gene

Proteomics data for OXSR1 Gene at MOPED

Post-translational modifications for OXSR1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys184

Other Protein References for OXSR1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for OXSR1 Gene

Gene Families for OXSR1 Gene

Suggested Antigen Peptide Sequences for OXSR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95747

UniProtKB/Swiss-Prot:

OXSR1_HUMAN
Domain:
  • Contains 1 protein kinase domain.:
    • O95747
Family:
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.:
    • O95747
genes like me logo Genes that share domains with OXSR1: view

Function for OXSR1 Gene

Molecular function for OXSR1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: By autophosphorylation on threonine.
UniProtKB/Swiss-Prot Function: Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton.

Enzyme Numbers (IUBMB) for OXSR1 Gene

Gene Ontology (GO) - Molecular Function for OXSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 14707132
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 14707132
GO:0004702 receptor signaling protein serine/threonine kinase activity IBA --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with OXSR1: view
genes like me logo Genes that share phenotypes with OXSR1: view

Animal Models for OXSR1 Gene

MGI Knock Outs for OXSR1:

miRNA for OXSR1 Gene

miRTarBase miRNAs that target OXSR1

No data available for Transcription Factor Targeting and HOMER Transcription for OXSR1 Gene

Localization for OXSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXSR1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OXSR1 Gene COMPARTMENTS Subcellular localization image for OXSR1 gene
Compartment Confidence
cytosol 3
mitochondrion 3
plasma membrane 3
nucleus 2
extracellular 1

Gene Ontology (GO) - Cellular Components for OXSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with OXSR1: view

Pathways for OXSR1 Gene

genes like me logo Genes that share pathways with OXSR1: view

Pathways by source for OXSR1 Gene

1 Cell Signaling Technology pathway for OXSR1 Gene
1 PharmGKB pathway for OXSR1 Gene

Gene Ontology (GO) - Biological Process for OXSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IDA 14707132
GO:0006979 response to oxidative stress IEA --
GO:0018107 peptidyl-threonine phosphorylation IDA 24393035
GO:0023014 signal transduction by protein phosphorylation IEA --
GO:0035556 intracellular signal transduction IDA 14707132
genes like me logo Genes that share ontologies with OXSR1: view

Compounds for OXSR1 Gene

(4) HMDB Compounds for OXSR1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Chlorine
  • Cl2
16887-00-6
Magnesium
  • Magnesium
7439-95-4

(6) Novoseek inferred chemical compound relationships for OXSR1 Gene

Compound -log(P) Hits PubMed IDs
proline 74.1 9
thiazide 67.5 1
lysine 57.1 4
chloride 45.3 2
threonine 27.7 2
genes like me logo Genes that share compounds with OXSR1: view

Transcripts for OXSR1 Gene

Unigene Clusters for OXSR1 Gene

Oxidative-stress responsive 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OXSR1 Gene

No ASD Table

Relevant External Links for OXSR1 Gene

GeneLoc Exon Structure for
OXSR1
ECgene alternative splicing isoforms for
OXSR1

Expression for OXSR1 Gene

mRNA expression in normal human tissues for OXSR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OXSR1 Gene

SOURCE GeneReport for Unigene cluster for OXSR1 Gene Hs.475970

mRNA Expression by UniProt/SwissProt for OXSR1 Gene

O95747-OXSR1_HUMAN
Tissue specificity: Ubiquitously expressed in all tissue examined.
genes like me logo Genes that share expressions with OXSR1: view

No data available for mRNA differential expression in normal tissues for OXSR1 Gene

Orthologs for OXSR1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OXSR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OXSR1 35
  • 99.75 (n)
  • 99.62 (a)
OXSR1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OXSR1 35
  • 93.04 (n)
  • 97.15 (a)
OXSR1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OXSR1 35
  • 93.99 (n)
  • 97.15 (a)
OXSR1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oxsr1 35
  • 90.51 (n)
  • 95.83 (a)
Oxsr1 16
Oxsr1 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OXSR1 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OXSR1 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oxsr1 35
  • 90.58 (n)
  • 95.83 (a)
chicken
(Gallus gallus)
Aves OXSR1 35
  • 81.4 (n)
  • 87.86 (a)
OXSR1 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OXSR1 36
  • 88 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12346 35
tropical clawed frog
(Silurana tropicalis)
Amphibia stk39 35
  • 75.37 (n)
  • 87.24 (a)
Str.5309 35
zebrafish
(Danio rerio)
Actinopterygii oxsr1a 36
  • 82 (a)
OneToMany
oxsr1b 36
  • 82 (a)
OneToMany
zgc55494 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006715 35
  • 54.04 (n)
  • 58.52 (a)
fruit fly
(Drosophila melanogaster)
Insecta fray 35
  • 56.8 (n)
  • 57.84 (a)
fray 36
  • 53 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gck-3 35
  • 58.97 (n)
  • 59.04 (a)
gck-3 36
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CLA4 36
  • 13 (a)
ManyToMany
SKM1 36
  • 16 (a)
ManyToMany
rice
(Oryza sativa)
Liliopsida Os.18600 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5075 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9457 36
  • 61 (a)
OneToMany
Species with no ortholog for OXSR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OXSR1 Gene

ENSEMBL:
Gene Tree for OXSR1 (if available)
TreeFam:
Gene Tree for OXSR1 (if available)

Paralogs for OXSR1 Gene

Paralogs for OXSR1 Gene

genes like me logo Genes that share paralogs with OXSR1: view

Variants for OXSR1 Gene

Sequence variations from dbSNP and Humsavar for OXSR1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2011 -- 38,255,326(-) TCCTC(C/T)AGATT utr-variant-3-prime
rs128403 -- 38,235,011(+) tcaat(C/T)tatgt intron-variant
rs128404 -- 38,235,073(+) actta(C/G)gactg intron-variant
rs149586 -- 38,235,114(+) ctaaa(A/G)agtat intron-variant
rs149822 -- 38,233,043(+) tgaca(A/G)tctta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OXSR1 Gene

Variant ID Type Subtype PubMed ID
esv274896 CNV Loss 21479260
nsv3768 CNV Insertion 18451855

Relevant External Links for OXSR1 Gene

HapMap Linkage Disequilibrium report
OXSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXSR1 Gene

Disorders for OXSR1 Gene

Relevant External Links for OXSR1

Human Genome Epidemiology (HuGE) Navigator
OXSR1
genes like me logo Genes that share disorders with OXSR1: view

No data available for UniProtKB/Swiss-Prot for OXSR1 Gene

Publications for OXSR1 Gene

  1. Isolation and characterization of a novel serine threonine kinase gene on chromosome 3p22-21.3. (PMID: 10083736) Tamari M. … Nakamura Y. (J. Hum. Genet. 1999) 2 3 4
  2. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R. … Ohara O. (DNA Res. 1999) 3 4
  3. Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1. (PMID: 18270262) Richardson C. … Alessi D.R. (J. Cell. Sci. 2008) 3 23
  4. WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1. (PMID: 16263722) Moriguchi T. … Shibuya H. (J. Biol. Chem. 2005) 3 23
  5. Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1. (PMID: 16669787) Vitari A.C. … Alessi D.R. (Biochem. J. 2006) 3 23

Products for OXSR1 Gene

  • Addgene plasmids for OXSR1

Sources for OXSR1 Gene

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