Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OXSM Gene

Aliases for OXSM Gene

  • 3-Oxoacyl-ACP Synthase, Mitochondrial 2 3
  • Beta-Ketoacyl-ACP Synthase 3 4
  • Beta-Ketoacyl Synthase 2 3
  • EC 4 64
  • KS 3 6
  • 3-Oxoacyl-[Acyl-Carrier-Protein] Synthase, Mitochondrial 3
  • Acyl-Malonyl Acyl Carrier Protein-Condensing Enzyme 3
  • Type II Mitochondrial Beta-Ketoacyl Synthase 3
  • 3-Ketoacyl-Acyl Carrier Protein Synthase 3
  • 3-Oxoacyl-Acyl-Carrier-Protein Synthase 3
  • EC 2.3.1 64
  • FASN2D 3
  • KASI 3

External Ids for OXSM Gene

Summaries for OXSM Gene

Entrez Gene Summary for OXSM Gene

  • This gene encodes a beta-ketoacyl synthetase. The encoded enzyme is required for elongation of fatty acid chains in the mitochondria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

GeneCards Summary for OXSM Gene

OXSM (3-Oxoacyl-ACP Synthase, Mitochondrial) is a Protein Coding gene. Diseases associated with OXSM include phaeohyphomycosis. Among its related pathways are Metabolism and Fatty acid metabolism. GO annotations related to this gene include 3-oxoacyl-[acyl-carrier-protein] synthase activity. An important paralog of this gene is FASN.

UniProtKB/Swiss-Prot for OXSM Gene

  • May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXSM Gene

Genomics for OXSM Gene

Genomic Location for OXSM Gene

25,782,917 bp from pter
25,794,534 bp from pter
11,618 bases
Plus strand

Genomic View for OXSM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OXSM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXSM Gene

Regulatory Elements for OXSM Gene

Proteins for OXSM Gene

  • Protein details for OXSM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial
    Protein Accession:
    Secondary Accessions:

    Protein attributes for OXSM Gene

    459 amino acids
    Molecular mass:
    48843 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for OXSM Gene

    Alternative splice isoforms for OXSM Gene


neXtProt entry for OXSM Gene

Proteomics data for OXSM Gene at MOPED

Selected DME Specific Peptides for OXSM Gene

Post-translational modifications for OXSM Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OXSM Gene

Domains for OXSM Gene


  • Belongs to the beta-ketoacyl-ACP synthases family.:
    • Q9NWU1
genes like me logo Genes that share domains with OXSM: view

No data available for Gene Families for OXSM Gene

Function for OXSM Gene

Molecular function for OXSM Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=3.9 uM for C4-[acyl-carrier-protein] {ECO:0000269 PubMed:15668256}; KM=1.9 uM for C6-[acyl-carrier-protein] {ECO:0000269 PubMed:15668256}; KM=10.9 uM for C8-[acyl-carrier-protein] {ECO:0000269 PubMed:15668256}; KM=1.8 uM for C10-[acyl-carrier-protein] {ECO:0000269 PubMed:15668256}; KM=9.5 uM for C12-[acyl-carrier-protein] {ECO:0000269 PubMed:15668256}; KM=50.8 uM for C14-[acyl-carrier-protein] {ECO:0000269 PubMed:15668256}; Vmax=129 nmol/min/mg enzyme toward C4-[acyl-carrier-protein] {ECO:0000269 PubMed:15668256}; Vmax=241 nmol/min/mg enzyme toward C6-[acyl-carrier-protein] {ECO:0000269 PubMed:15668256}; Vmax=271 nmol/min/mg enzyme toward C8-[acyl-carrier-protein] {ECO:0000269 PubMed:15668256}; Vmax=364 nmol/min/mg enzyme toward C10-[acyl-carrier-protein] {ECO:0000269 PubMed:15668256}; Vmax=1045 nmol/min/mg enzyme toward C12-[acyl-carrier-protein] {ECO:0000269 PubMed:15668256}; Vmax=115 nmol/min/mg enzyme toward C14-[acyl-carrier-protein] {ECO:0000269 PubMed:15668256}; Note=The highest catalytic efficiency is observed for C10-[acyl- carrier-protein].;
UniProtKB/Swiss-Prot CatalyticActivity: Acyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein]
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by cerulenin.
UniProtKB/Swiss-Prot Function: May play a role in the biosynthesis of lipoic acid as well as longer chain fatty acids required for optimal mitochondrial function.

Enzyme Numbers (IUBMB) for OXSM Gene

Gene Ontology (GO) - Molecular Function for OXSM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity IDA 15668256
GO:0016740 transferase activity --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
genes like me logo Genes that share ontologies with OXSM: view

Phenotypes for OXSM Gene

GenomeRNAi human phenotypes for OXSM:
genes like me logo Genes that share phenotypes with OXSM: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OXSM Gene

Localization for OXSM Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXSM Gene


Subcellular locations from

Jensen Localization Image for OXSM Gene COMPARTMENTS Subcellular localization image for OXSM gene
Compartment Confidence
mitochondrion 5
cytosol 3
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for OXSM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IMP 15668256
genes like me logo Genes that share ontologies with OXSM: view

Pathways for OXSM Gene

genes like me logo Genes that share pathways with OXSM: view

Pathways by source for OXSM Gene

UniProtKB/Swiss-Prot Q9NWU1-OXSM_HUMAN

  • Pathway: Lipid metabolism; fatty acid biosynthesis

Gene Ontology (GO) - Biological Process for OXSM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006633 fatty acid biosynthetic process --
GO:0006637 acyl-CoA metabolic process IDA 15668256
GO:0008152 metabolic process --
GO:0051790 short-chain fatty acid biosynthetic process IDA 15668256
GO:0051792 medium-chain fatty acid biosynthetic process IDA 15668256
genes like me logo Genes that share ontologies with OXSM: view

Compounds for OXSM Gene

(9) HMDB Compounds for OXSM Gene

Compound Synonyms Cas Number PubMed IDs
(R)-3-Hydroxy-hexadecanoic acid
Not Available
3-Oxodecanoic acid
Not Available
3-Oxododecanoic acid
  • 3-Oxo-Dodecanoic acid
Not Available
3-Oxohexadecanoic acid
  • 3-Oxo-hexadecanoic acid
Not Available
3-Oxotetradecanoic acid
  • 3-Oxo-tetradecanoic acid
Not Available

(1) Novoseek inferred chemical compound relationships for OXSM Gene

Compound -log(P) Hits PubMed IDs
palmitate 56.7 2
genes like me logo Genes that share compounds with OXSM: view

Transcripts for OXSM Gene

Unigene Clusters for OXSM Gene

3-oxoacyl-ACP synthase, mitochondrial:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OXSM Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2: -

Relevant External Links for OXSM Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OXSM Gene

mRNA expression in normal human tissues for OXSM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OXSM Gene

SOURCE GeneReport for Unigene cluster for OXSM Gene Hs.55781

mRNA Expression by UniProt/SwissProt for OXSM Gene

Tissue specificity: Widely expressed. Higher expression in heart, skeletal muscle, liver and kidney which contain high levels of active mitochondria.
genes like me logo Genes that share expressions with OXSM: view

Orthologs for OXSM Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OXSM Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OXSM 36
  • 99.78 (n)
  • 99.56 (a)
  • 100 (a)
(Bos Taurus)
Mammalia OXSM 36
  • 80.46 (n)
  • 83.22 (a)
  • 82 (a)
(Canis familiaris)
Mammalia OXSM 36
  • 91.12 (n)
  • 92.14 (a)
  • 92 (a)
(Mus musculus)
Mammalia Oxsm 36
  • 83.55 (n)
  • 85.15 (a)
Oxsm 16
Oxsm 37
  • 85 (a)
(Monodelphis domestica)
Mammalia OXSM 37
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 7 (a)
(Rattus norvegicus)
Mammalia Oxsm 36
  • 83.96 (n)
  • 86.37 (a)
(Gallus gallus)
Aves OXSM 36
  • 73.16 (n)
  • 74.18 (a)
  • 73 (a)
(Anolis carolinensis)
Reptilia OXSM 37
  • 70 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12767 36
tropical clawed frog
(Silurana tropicalis)
Amphibia oxsm 36
  • 70.9 (n)
  • 72.34 (a)
(Danio rerio)
Actinopterygii LOC564649 36
  • 65.87 (n)
  • 70.81 (a)
  • 66 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002809 36
  • 54.03 (n)
  • 56.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12170 36
  • 55.58 (n)
  • 55.42 (a)
CG12170 37
  • 50 (a)
(Caenorhabditis elegans)
Secernentea F10G8.9 37
  • 41 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL072C 36
  • 48.18 (n)
  • 42.34 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CEM1 36
  • 50.08 (n)
  • 44.03 (a)
CEM1 37
  • 38 (a)
CEM1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C08239g 36
  • 47.26 (n)
  • 40.29 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT2G04540 36
  • 55.05 (n)
  • 52.98 (a)
(Zea mays)
Liliopsida Zm.7885 36
(Oryza sativa)
Liliopsida Os.37967 36
Os02g0196900 36
  • 60.14 (n)
  • 59.57 (a)
(Triticum aestivum)
Liliopsida Ta.1178 36
bread mold
(Neurospora crassa)
Ascomycetes NCU00056 36
  • 54.8 (n)
  • 52.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC887.13c 36
  • 55.02 (n)
  • 50.73 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.12046 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 59 (a)
Species with no ortholog for OXSM:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for OXSM Gene

Gene Tree for OXSM (if available)
Gene Tree for OXSM (if available)

Paralogs for OXSM Gene

Paralogs for OXSM Gene

genes like me logo Genes that share paralogs with OXSM: view

Variants for OXSM Gene

Sequence variations from dbSNP and Humsavar for OXSM Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs2035695 -- 25,792,911(+) gtaat(A/G)ggaaa intron-variant
rs2932014 -- 25,792,679(+) gtttc(A/G)cttta intron-variant
rs2968175 -- 25,793,169(-) CTCTA(C/T)TAAAA intron-variant
rs9831075 -- 25,794,532(+) AAATG(C/T)TATAT utr-variant-3-prime, nc-transcript-variant
rs9834955 -- 25,794,597(+) TTCTC(A/C)ACCTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OXSM Gene

Variant ID Type Subtype PubMed ID
nsv876633 CNV Gain 21882294
dgv71n17 CNV Loss 16327808

Relevant External Links for OXSM Gene

HapMap Linkage Disequilibrium report

Disorders for OXSM Gene

(1) MalaCards Diseases for OXSM Gene

Search for OXSM Gene in MalaCards »

(2) University of Copenhagen DISEASES for OXSM Gene

Relevant External Links for OXSM

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with OXSM: view

No data available for UniProtKB/Swiss-Prot for OXSM Gene

Publications for OXSM Gene

  1. Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain. (PMID: 15668256) Zhang L. … Smith S. (J. Biol. Chem. 2005) 3 4 23
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 49

Products for OXSM Gene

Sources for OXSM Gene

Back to Top