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OXR1 Gene

protein-coding   GIFtS: 52
GCID: GC08P107282

Oxidation Resistance 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Oxidation Resistance 11 2
TBC/LysM-Associated Domain Containing 31 2
TLDC32
Oxidation Resistance Protein 12
Putative Protein Product Of Nbla003072

External Ids:    HGNC: 158221   Entrez Gene: 550742   Ensembl: ENSG000001648307   OMIM: 6056095   UniProtKB: Q8N5733   

Export aliases for OXR1 gene to outside databases

Previous GC identifers: GC08P106704 GC08P107697 GC08P107299 GC08P107586 GC08P107626 GC08P107699 GC08P102604


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OXR1 Gene:
OXR1 (oxidation resistance 1) is a protein-coding gene. Diseases associated with OXR1 include neuroblastoma, and tonsillitis. An important paralog of this gene is TLDC1.

UniProtKB/Swiss-Prot: OXR1_HUMAN, Q8N573
Function: May be involved in protection from oxidative damage

Gene Wiki entry for OXR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000008.11  NT_008046.17  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OXR1 gene promoter:
         TBP   HNF-4alpha2   RelA   AP-4   NF-kappaB   HNF-4alpha1   S8   Cart-1   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOXR1 promoter sequence
   Search Chromatin IP Primers for OXR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OXR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23   Ensembl cytogenetic band:  8q23.1   HGNC cytogenetic band: 8q23

OXR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OXR1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P107282:  view genomic region     (about GC identifiers)

Start:
107,282,406 bp from pter      End:
107,764,922 bp from pter
Size:
482,517 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: OXR1_HUMAN, Q8N573 (See protein sequence)
Recommended Name: Oxidation resistance protein 1  
Size: 874 amino acids; 97970 Da
Sequence caution: Sequence=AAG25715.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH32710.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAY26396.1;
Type=Erroneous gene model prediction; Sequence=BAA91456.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=BAF85588.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAI46186.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NK11 A8KA34 B3KXL1 B7Z402 B7Z8N5 D3HIS6 Q3LIB5 Q6ZVK9 Q8N8V0 Q9H266
Q9NWC7
Alternative splicing: 8 isoforms:  Q8N573-1   Q8N573-2   Q8N573-3   Q8N573-4   Q8N573-5   Q8N573-6   Q8N573-7   Q8N573-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OXR1: NX_Q8N573

Explore proteomics data for OXR1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OXR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001185461.1  NP_001185462.1  NP_001185463.1  NP_001185464.1  NP_060472.2  NP_851999.2  

    ENSEMBL proteins: 
     ENSP00000431966   ENSP00000429205   ENSP00000429438   ENSP00000431014   ENSP00000387886  
     ENSP00000311026   ENSP00000414992   ENSP00000430701   ENSP00000408659   ENSP00000297447  
     ENSP00000435104   ENSP00000402918   ENSP00000405424   ENSP00000395032  

    OXR1 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for OXR1
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    Novus Biologicals OXR1 Lysate
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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for OXR1

    OXR1 Antibody Products:

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    OXR1 Assay Products:

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    Cloud-Clone Corp. CLIAs for OXR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR018392 LysM_dom
     IPR006571 TLDc

    Graphical View of Domain Structure for InterPro Entry Q8N573

    ProtoNet protein and cluster: Q8N573

    1 Blocks protein domain: IPB002482 Peptidoglycan-binding LysM

    UniProtKB/Swiss-Prot: OXR1_HUMAN, Q8N573
    Similarity: Belongs to the OXR1 family
    Similarity: Contains 1 GRAM domain
    Similarity: Contains 1 LysM repeat
    Similarity: Contains 1 TLD domain


    OXR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OXR1_HUMAN, Q8N573
    Function: May be involved in protection from oxidative damage
    Induction: By heat shock and oxidative stress

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0016491oxidoreductase activity IEA--
         
    OXR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OXR1:
     Cell cycle / mitosis defect 

         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Oxr1):
     behavior/neurological  growth/size/body  integument  mortality/aging 

    OXR1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OXR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OXR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OXR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OXR1

    miRNA
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    miRTarBase miRNAs that target OXR1:
    hsa-let-7b-5p (MIRT052140)

    Block miRNA regulation of human, mouse, rat OXR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OXR1 (see all 47):
    hsa-miR-4291 hsa-miR-3685 hsa-miR-302d hsa-miR-520e hsa-miR-429 hsa-miR-106a hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidOXR1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for OXR1
    Predesigned siRNA for gene silencing in human, mouse, rat OXR1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for OXR1

    Clone
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    OriGene clones in human, mouse for OXR1 (see all 33)
    OriGene ORF clones in mouse, rat for OXR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): OXR1 (NM_001198535)
    Sino Biological Human cDNA Clone for OXR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OXR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXR1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for OXR1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OXR1_HUMAN, Q8N573: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    cytosol2
    nucleus2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005730nucleolus IEA--
    GO:0005739mitochondrion IEA--

    OXR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Arrays including OXR1: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for OXR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for OXR1 (ENSP000004029184) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KLHDC3ENSP000003139954STRING: ENSP00000313995
    ATP13A2ENSP000003272144STRING: ENSP00000327214
    ATP13A3ENSP000002560314STRING: ENSP00000256031
    ATP13A4ENSP000003391824STRING: ENSP00000339182
    ATP13A5ENSP000003419424STRING: ENSP00000341942
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979response to oxidative stress NAS11114193
    GO:0007628adult walking behavior IEA--
    GO:0016998cell wall macromolecule catabolic process IEA--
    GO:0043524negative regulation of neuron apoptotic process IEA--
    GO:0055114oxidation-reduction process ----

    OXR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OXR1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for OXR1 gene (6 alternative transcripts): 
    NM_001198532.1  NM_001198533.1  NM_001198534.1  NM_001198535.1  NM_018002.3  NM_181354.4  

    Unigene Cluster for OXR1:

    Oxidation resistance 1
    Hs.127286  [show with all ESTs]
    Unigene Representative Sequence: BC040619
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531443 ENST00000517566(uc011lht.2) ENST00000517686 ENST00000521963
    ENST00000497705(uc003ymg.1) ENST00000435082 ENST00000312046(uc003ymi.1 uc011lhu.2 uc010mcg.3 uc010mch.3)
    ENST00000438229 ENST00000517455 ENST00000519415 ENST00000449762(uc003ymk.3 uc003yml.3)
    ENST00000297447 ENST00000521592 ENST00000521864 ENST00000445937(uc022azp.1 uc003ymf.3)
    ENST00000442977 ENST00000452423
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OXR1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OXR1 (see all 47):
    hsa-miR-4291 hsa-miR-3685 hsa-miR-302d hsa-miR-520e hsa-miR-429 hsa-miR-106a hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidOXR1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for OXR1
    Predesigned siRNA for gene silencing in human, mouse, rat OXR1
    Clone
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    OriGene clones in human, mouse for OXR1 (see all 33)
    OriGene ORF clones in mouse, rat for OXR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): OXR1 (NM_001198535)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OXR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXR1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for OXR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OXR1
      QuantiTect SYBR Green Assays in human, mouse, rat OXR1
      QuantiFast Probe-based Assays in human, mouse, rat OXR1

    Additional mRNA sequence: BC040619.1 

    2 DOTS entries:

    DT.97838217  DT.307017 

    Selected AceView cDNA sequences (see all 224):

    H38420 BC019691 AU118139 AL043961 BG613295 CK430292 AK096148 CR596350 
    AI580515 NM_181354 CD299925 AA447499 CN478985 AU122718 BE350152 AA385498 
    BM693195 BC032710 BQ027293 BX103857 AK000987 BM023444 AA922747 AK123667 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for OXR1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                                                                                -                 -     -                                             
    SP2:                                                                                -                 -                                                   
    SP3:                                                                                                                                                      
    SP4:        -     -     -     -                                                                                                                           
    SP5:                                                                                -                 -     -     -                                       


    ECgene alternative splicing isoforms for OXR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OXR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACAGTGAC
    OXR1 Expression
    About this image


    OXR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Pancreas (Endocrine System)
             Islets of Langerhans
    OXR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OXR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.127286
        Pathway & Disease-focused RT2 Profiler PCR Arrays including OXR1: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for OXR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OXR1
    QuantiTect SYBR Green Assays in human, mouse, rat OXR1
    QuantiFast Probe-based Assays in human, mouse, rat OXR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OXR1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oxr11 , 5 oxidation resistance 11, 5 84.49(n)1
    85.3(a)1
      15 (16.06 cM)5
    1707191  NM_001130166.11  NP_001123638.11 
     414474825 
    chicken
    (Gallus gallus)
    Aves OXR11 oxidation resistance 1 74.84(n)
    75.14(a)
      420270  XM_004939987.1  XP_004940044.1 
    lizard
    (Anolis carolinensis)
    Reptilia OXR16
    oxidation resistance 1
    70(a)
    1 ↔ 1
    4(12016877-12288056)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.161332 Xenopus laevis transcribed sequence with moderate similarity more 82.07(n)    BJ620127.1 
    zebrafish
    (Danio rerio)
    Actinopterygii oxr1a1 oxidation resistance 1a 65.6(n)
    67.49(a)
      571418  NM_001114444.1  NP_001107916.1 


    ENSEMBL Gene Tree for OXR1 (if available)
    TreeFam Gene Tree for OXR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OXR1 gene
    TLDC12  NCOA72  TLDC22  
    8 SIMAP similar genes for OXR1 using alignment to 7 protein entries:     OXR1_HUMAN (see all proteins):
    TLDC2    C20orf118    NCOA7    TBC1D24    DKFZp451P0217    TLDC1
    DKFZp761B2210    Nbla00052

    OXR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OXR1
    PGOHUM00000247110


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OXR1 (see all 8740)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344255941,2
    C--102940010(+) GCTAA-/TTTTTT 3 -- int10--------
    rs713070801,2
    C--102979907(+) TCGCT-/ATGTTGG 3 -- int11Minor allele frequency- AT:0.00NA 2
    rs1152684861,2
    C,F--107280473(+) TTTTCA/TCCTTC 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1489815681,2
    --107280495(+) ATAGAA/TAGGAA 2 -- us2k10--------
    rs796722871,2
    --107280638(+) AAAGTA/GAAAGA 2 -- us2k11Minor allele frequency- G:0.01EA 120
    rs762051381,2
    C,F--107280645(+) AAGATC/AAAACC 2 -- us2k12Minor allele frequency- A:0.07CSA WA 120
    rs1897493081,2
    --107280698(+) CAAGTA/GGGGAT 2 -- us2k10--------
    rs1813329931,2
    --107280858(+) TCACAA/GAGTCT 2 -- us2k10--------
    rs1859599751,2
    --107280937(+) TTCTGA/GTAGAA 2 -- us2k10--------
    rs2022375401,2
    --107281345(+) TACCT-/CTTA  
            
    CTTTA
    2 -- us2k10--------

    HapMap Linkage Disequilibrium report for OXR1 (107282406 - 107532406 bp, first 250kb of OXR1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for OXR1 (see all 39):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2737403CNV Deletion23290073
    esv1172684CNV Deletion17803354
    esv2737400CNV Deletion23290073
    esv2838CNV Deletion18987735
    esv2497761CNV Deletion19546169
    esv2646049CNV Deletion19546169
    esv2737401CNV Deletion23290073
    esv2602152CNV Deletion19546169
    esv2283630CNV Deletion18987734
    esv2737404CNV Deletion23290073

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605609    OMIM disorders: --

    7 diseases for OXR1:    
    About MalaCards
    neuroblastoma    tonsillitis    thyroiditis    breast cancer
    cerebritis    endotheliitis    prostatitis


    OXR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OXR1
    Human Genome Epidemiology (HuGE) Navigator: OXR1 (1 document)

    Export disorders for OXR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OXR1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with OXR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional genomics reveals a family of eukaryotic oxidation protection genes. (PubMed id 11114193)1, 2, 3 Volkert M.R.... Housman D.E. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    2. Structural/functional analysis of the human OXR1 protein: identification of exon 8 as the anti-oxidant encoding function. (PubMed id 22873401)1, 2 Murphy K.C. and Volkert M.R. (BMC Mol. Biol. 2012)
    3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Stress induction and mitochondrial localization of Oxr1 proteins in yeast and humans. (PubMed id 15060142)1, 2 Elliott N.A. and Volkert M.R. (Mol. Cell. Biol. 2004)
    8. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)1, 2 Ohira M.... Nakagawara A. (Cancer Lett. 2003)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    10. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55074 HGNC: 15822 AceView: OXR1 Ensembl:ENSG00000164830 euGenes: HUgn55074
    ECgene: OXR1 H-InvDB: OXR1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for OXR1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/oxr1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for OXR1 gene:
    Search GeneIP for patents involving OXR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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