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Aliases for OXR1 Gene

Aliases for OXR1 Gene

  • Oxidation Resistance 1 2 3
  • TBC/LysM-Associated Domain Containing 3 2 3
  • Putative Protein Product Of Nbla00307 3
  • Oxidation Resistance Protein 1 3
  • Nbla00307 3
  • TLDC3 3

External Ids for OXR1 Gene

Summaries for OXR1 Gene

GeneCards Summary for OXR1 Gene

OXR1 (Oxidation Resistance 1) is a Protein Coding gene. An important paralog of this gene is TLDC2.

UniProtKB/Swiss-Prot for OXR1 Gene

  • May be involved in protection from oxidative damage.

Gene Wiki entry for OXR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXR1 Gene

Genomics for OXR1 Gene

Genomic Location for OXR1 Gene

Start:
106,270,178 bp from pter
End:
106,752,694 bp from pter
Size:
482,517 bases
Orientation:
Plus strand

Genomic View for OXR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OXR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXR1 Gene

Regulatory Elements for OXR1 Gene

Proteins for OXR1 Gene

  • Protein details for OXR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N573-OXR1_HUMAN
    Recommended name:
    Oxidation resistance protein 1
    Protein Accession:
    Q8N573
    Secondary Accessions:
    • A6NK11
    • A8KA34
    • B3KXL1
    • B7Z402
    • B7Z8N5
    • D3HIS6
    • Q3LIB5
    • Q6ZVK9
    • Q8N8V0
    • Q9H266
    • Q9NWC7

    Protein attributes for OXR1 Gene

    Size:
    874 amino acids
    Molecular mass:
    97970 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG25715.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH32710.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAY26396.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA91456.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAF85588.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI46186.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for OXR1 Gene

neXtProt entry for OXR1 Gene

Proteomics data for OXR1 Gene at MOPED

Post-translational modifications for OXR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OXR1 Gene

Domains for OXR1 Gene

Protein Domains for OXR1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N573

UniProtKB/Swiss-Prot:

OXR1_HUMAN
Domain:
  • Contains 1 GRAM domain.:
    • Q8N573
  • Contains 1 TLD domain.:
    • Q8N573
Family:
  • Belongs to the OXR1 family.:
    • Q8N573
Similarity:
  • Contains 1 LysM repeat.:
    • Q8N573
genes like me logo Genes that share domains with OXR1: view

No data available for Gene Families for OXR1 Gene

Function for OXR1 Gene

Molecular function for OXR1 Gene

UniProtKB/Swiss-Prot Function: May be involved in protection from oxidative damage.
UniProtKB/Swiss-Prot Induction: By heat shock and oxidative stress.

Gene Ontology (GO) - Molecular Function for OXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with OXR1: view

Phenotypes for OXR1 Gene

genes like me logo Genes that share phenotypes with OXR1: view

miRNA for OXR1 Gene

miRTarBase miRNAs that target OXR1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for OXR1 Gene

Localization for OXR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXR1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OXR1 Gene COMPARTMENTS Subcellular localization image for OXR1 gene
Compartment Confidence
mitochondrion 5
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for OXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005730 nucleolus IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with OXR1: view

Pathways for OXR1 Gene

SuperPathways for OXR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress NAS 11114193
GO:0007628 adult walking behavior IEA --
GO:0043524 negative regulation of neuron apoptotic process IEA --
GO:0055114 oxidation-reduction process IEA --
GO:0071447 cellular response to hydroperoxide IEA --
genes like me logo Genes that share ontologies with OXR1: view

No data available for Pathways by source for OXR1 Gene

Transcripts for OXR1 Gene

Unigene Clusters for OXR1 Gene

Oxidation resistance 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OXR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - - -
SP2: - -
SP3:
SP4: - - - -
SP5: - - - -
SP6: -
SP7: - - - - - - - - - - - - -
SP8: -

Relevant External Links for OXR1 Gene

GeneLoc Exon Structure for
OXR1
ECgene alternative splicing isoforms for
OXR1

Expression for OXR1 Gene

mRNA expression in normal human tissues for OXR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OXR1 Gene

SOURCE GeneReport for Unigene cluster for OXR1 Gene Hs.127286

genes like me logo Genes that share expressions with OXR1: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OXR1 Gene

Orthologs for OXR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OXR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OXR1 35
  • 99.35 (n)
  • 99.19 (a)
OXR1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OXR1 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OXR1 35
  • 91.73 (n)
  • 91.04 (a)
OXR1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oxr1 35
  • 84.49 (n)
  • 85.3 (a)
Oxr1 16
Oxr1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OXR1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OXR1 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oxr1 35
  • 84.31 (n)
  • 86.22 (a)
chicken
(Gallus gallus)
Aves OXR1 35
  • 74.84 (n)
  • 75.14 (a)
OXR1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OXR1 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16133 35
tropical clawed frog
(Silurana tropicalis)
Amphibia oxr1 35
  • 71.07 (n)
  • 71.89 (a)
Str.9341 35
zebrafish
(Danio rerio)
Actinopterygii OXR1 (3 of 3) 36
  • 79 (a)
OneToMany
oxr1a 35
  • 65.6 (n)
  • 67.49 (a)
oxr1a 36
  • 62 (a)
OneToMany
oxr1b 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F52E1.13b 37
  • 37 (a)
F52E1.13c 37
  • 37 (a)
F52E1.13a 37
  • 37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10480 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7690 36
  • 33 (a)
OneToOne
Species with no ortholog for OXR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OXR1 Gene

ENSEMBL:
Gene Tree for OXR1 (if available)
TreeFam:
Gene Tree for OXR1 (if available)

Paralogs for OXR1 Gene

Paralogs for OXR1 Gene

Pseudogenes.org Pseudogenes for OXR1 Gene

genes like me logo Genes that share paralogs with OXR1: view

Variants for OXR1 Gene

Sequence variations from dbSNP and Humsavar for OXR1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs702776 -- 106,667,716(+) TGATA(G/T)ATACT intron-variant
rs702777 -- 106,667,872(+) GATGG(A/G)TGGTT intron-variant
rs725906 -- 106,708,888(-) actgc(C/T)gcagg intron-variant
rs731156 -- 106,431,317(-) AACAA(C/T)AGTTT intron-variant
rs736260 -- 106,430,650(+) CTATC(A/G)TGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OXR1 Gene

Variant ID Type Subtype PubMed ID
esv29304 CNV Loss 19812545
esv259431 OTHER Complex 20981092
esv2659632 CNV Deletion 23128226
nsv824701 CNV Loss 20364138
esv2672249 CNV Deletion 23128226
esv2737399 CNV Deletion 23290073
esv2737400 CNV Deletion 23290073
nsv397388 CNV Loss 16902084
esv270833 CNV Insertion 20981092
esv2456389 CNV Insertion 19546169
esv269507 CNV Insertion 20981092
esv2678972 CNV Deletion 23128226
dgv467n21 CNV Loss 19592680
esv2602152 CNV Deletion 19546169
esv2421125 CNV Deletion 18987734
esv1172684 CNV Deletion 17803354
esv2737401 CNV Deletion 23290073
esv5529 CNV Loss 19470904
nsv396328 CNV Loss 16902084
esv2646049 CNV Deletion 19546169
esv25447 CNV Gain 19812545
esv2737402 CNV Deletion 23290073
esv2283630 CNV Deletion 18987734
esv2737403 CNV Deletion 23290073
nsv396739 CNV Loss 16902084
esv988911 CNV Deletion 20482838
nsv396629 CNV Loss 16902084
esv26205 CNV Gain 19812545
nsv831419 CNV Loss 17160897
esv33830 CNV Loss 17666407
nsv6342 CNV Loss 18451855
esv268710 CNV Insertion 20981092
esv2497761 CNV Deletion 19546169
esv2178363 CNV Deletion 18987734
esv2838 CNV Deletion 18987735
esv2737404 CNV Deletion 23290073
esv5816 CNV Loss 19470904
esv1610500 CNV Deletion 17803354
nsv397838 CNV Loss 16902084

Relevant External Links for OXR1 Gene

HapMap Linkage Disequilibrium report
OXR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXR1 Gene

Disorders for OXR1 Gene

Relevant External Links for OXR1

Genetic Association Database (GAD)
OXR1
Human Genome Epidemiology (HuGE) Navigator
OXR1
genes like me logo Genes that share disorders with OXR1: view

No data available for UniProtKB/Swiss-Prot for OXR1 Gene

Publications for OXR1 Gene

  1. Functional genomics reveals a family of eukaryotic oxidation protection genes. (PMID: 11114193) Volkert M.R. … Housman D.E. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  3. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PMID: 12880961) Ohira M. … Nakagawara A. (Cancer Lett. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Stress induction and mitochondrial localization of Oxr1 proteins in yeast and humans. (PMID: 15060142) Elliott N.A. … Volkert M.R. (Mol. Cell. Biol. 2004) 3 4

Products for OXR1 Gene

Sources for OXR1 Gene

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