Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OXR1 Gene

protein-coding   GIFtS: 51
GCID: GC08P107282

Oxidation Resistance 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Oxidation Resistance 11 2
TBC/LysM-Associated Domain Containing 31 2
TLDC32
Oxidation Resistance Protein 12
Putative Protein Product Of Nbla003072

External Ids:    HGNC: 158221   Entrez Gene: 550742   Ensembl: ENSG000001648307   OMIM: 6056095   UniProtKB: Q8N5733   

Export aliases for OXR1 gene to outside databases

Previous GC identifers: GC08P106704 GC08P107697 GC08P107299 GC08P107586 GC08P107626 GC08P107699 GC08P102604


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OXR1 Gene: 
OXR1 (oxidation resistance 1) is a protein-coding gene. Diseases associated with OXR1 include neuroblastoma, and breast cancer. GO annotations related to this gene include molecular_function. An important paralog of this gene is TLDC1.

UniProtKB/Swiss-Prot: OXR1_HUMAN, Q8N573
Function: May be involved in protection from oxidative damage

Gene Wiki entry for OXR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OXR1 gene promoter:
         TBP   HNF-4alpha2   RelA   AP-4   NF-kappaB   HNF-4alpha1   S8   Cart-1   NF-kappaB1   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOXR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for OXR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OXR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q23   Ensembl cytogenetic band:  8q23.1   HGNC cytogenetic band: 8q23

OXR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OXR1 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P107282:  view genomic region     (about GC identifiers)

Start:
107,282,406 bp from pter      End:
107,764,922 bp from pter
Size:
482,517 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OXR1_HUMAN, Q8N573 (See protein sequence)
Recommended Name: Oxidation resistance protein 1  
Size: 874 amino acids; 97970 Da
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAG25715.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAH32710.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAY26396.1;
Type=Erroneous gene model prediction; Sequence=BAA91456.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=BAF85588.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAI46186.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A6NK11 A8KA34 B3KXL1 B7Z402 B7Z8N5 D3HIS6 Q3LIB5 Q6ZVK9 Q8N8V0 Q9H266
Q9NWC7
Alternative splicing: 8 isoforms:  Q8N573-1   Q8N573-2   Q8N573-3   Q8N573-4   Q8N573-5   Q8N573-6   Q8N573-7   Q8N573-8   
(No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OXR1: NX_Q8N573

Explore proteomics data for OXR1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N573

  • OXR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OXR1 Protein Expression
    REFSEQ proteins (6 alternative transcripts): 
    NP_001185461.1  NP_001185462.1  NP_001185463.1  NP_001185464.1  NP_060472.2  NP_851999.2  

    ENSEMBL proteins: 
     ENSP00000431966   ENSP00000429205   ENSP00000429438   ENSP00000431014   ENSP00000387886  
     ENSP00000311026   ENSP00000414992   ENSP00000430701   ENSP00000408659   ENSP00000297447  
     ENSP00000435104   ENSP00000402918   ENSP00000405424   ENSP00000395032  

    Human Recombinant Protein Products for OXR1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for OXR1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for OXR1
    GenScript Custom Purified and Recombinant Proteins Services for OXR1
    Novus Biologicals OXR1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OXR1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005730nucleolus IEA--
    GO:0005739mitochondrion IEA--

    OXR1 for ontologies           About GeneDecksing



    OXR1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for OXR1
    GenScript Custom Superior Antibodies Services for OXR1
    Novus Biologicals OXR1 Antibodies
    Abcam antibodies for OXR1
    Cloud-Clone Corp. Antibodies for OXR1 
    ThermoFisher Antibodies for OXR1
    LSBio Antibodies in human, mouse, rat for OXR1 

    Assay Products for OXR1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OXR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OXR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OXR1 
    Cloud-Clone Corp. CLIAs for OXR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR018392 Peptidoglycan-bd_lysin
     IPR002482 Peptidoglycan-bd_Lysin_subgr
     IPR006571 TLDc
     IPR004182 GRAM

    Graphical View of Domain Structure for InterPro Entry Q8N573

    ProtoNet protein and cluster: Q8N573

    1 Blocks protein domain: IPB002482 Peptidoglycan-binding LysM

    UniProtKB/Swiss-Prot: OXR1_HUMAN, Q8N573
    Similarity: Belongs to the OXR1 family
    Similarity: Contains 1 GRAM domain
    Similarity: Contains 1 LysM repeat
    Similarity: Contains 1 TLD domain


    OXR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OXR1_HUMAN, Q8N573
    Function: May be involved in protection from oxidative damage
    Induction: By heat shock and oxidative stress

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    OXR1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for OXR1:
     Cell cycle / mitosis defect 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Oxr1):
     behavior/neurological  growth/size  mortality/aging 

    OXR1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for OXR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OXR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OXR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OXR1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OXR1
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate OXR1 (see all 47):
    hsa-miR-4291 hsa-miR-3685 hsa-miR-302d hsa-miR-520e hsa-miR-429 hsa-miR-106a hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidOXR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OXR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OXR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OXR1
    Sirion Biotech Customized adenovirus for overexpression of OXR1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for OXR1 (see all 28)
    OriGene ORF clones in mouse, rat for OXR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): OXR1 (NM_001198535)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OXR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXR1
    Sirion Biotech Customized lentivirus for stable overexpression of OXR1 
                         Customized lentivirus expression plasmids for stable overexpression of OXR1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OXR1
    Search LifeMap BioReagents cell lines for OXR1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OXR1

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006979response to oxidative stress NAS11114193
    GO:0016998cell wall macromolecule catabolic process IEA--

    OXR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OXR1

    Search CenterWatch for drugs/clinical trials and news about OXR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for OXR1 gene (6 alternative transcripts): 
    NM_001198532.1  NM_001198533.1  NM_001198534.1  NM_001198535.1  NM_018002.3  NM_181354.4  

    Unigene Clusters for OXR1:

    Oxidation resistance 1
    Hs.127286  [show with all ESTs], Hs.701892  [show with all ESTs]
    Unigene Representative Sequences: BC040619, NM_001198533
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000531443 ENST00000517566(uc011lht.2) ENST00000517686 ENST00000521963
    ENST00000497705(uc003ymg.1) ENST00000435082 ENST00000312046(uc003ymi.1 uc011lhu.2 uc010mcg.3 uc010mch.3)
    ENST00000438229 ENST00000517455 ENST00000519415 ENST00000449762(uc003ymk.3 uc003yml.3)
    ENST00000297447 ENST00000521592 ENST00000521864 ENST00000445937(uc022azp.1 uc003ymf.3)
    ENST00000442977 ENST00000452423
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat OXR1
    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate OXR1 (see all 47):
    hsa-miR-4291 hsa-miR-3685 hsa-miR-302d hsa-miR-520e hsa-miR-429 hsa-miR-106a hsa-miR-30d hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidOXR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for OXR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OXR1
    Clone
    Products:
         
    OriGene clones in human, mouse for OXR1 (see all 28)
    OriGene ORF clones in mouse, rat for OXR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): OXR1 (NM_001198535)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OXR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXR1
    Sirion Biotech Customized lentivirus for stable overexpression of OXR1 
                         Customized lentivirus expression plasmids for stable overexpression of OXR1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for OXR1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OXR1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OXR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OXR1

    Additional mRNA sequence: 

    AB075503.1 AF309387.1 AK000987.1 AK096148.1 AK123667.1 AK124441.1 AK292899.1 AK296561.1 
    AK302844.1 AK303695.1 AK316153.1 AL833193.1 BC019691.1 BC032710.2 BC035484.1 FN650108.1 
    FN650109.1 

    19 DOTS entries:

    DT.100690190  DT.320250  DT.92435977  DT.40301006  DT.97838217  DT.120639695  DT.320248  DT.40207952 
    DT.99961852  DT.92417874  DT.120639692  DT.307017  DT.92435985  DT.86841782  DT.100820436  DT.100842446 
    DT.120639722  DT.102827154  DT.120639682 

    24/224 AceView cDNA sequences (see all 224):

    AU118139 AL043961 BG613295 CK430292 AK096148 CR596350 AI580515 NM_181354 
    CD299925 AA447499 CN478985 AU122718 BE350152 AA385498 BM729283 BM722366 
    BU507772 N95837 BM801692 CB162068 AA307512 AL548574 BM693195 BC032710 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for OXR1 (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
    SP1:                                                                                -                 -     -                                             
    SP2:                                                                                -                 -                                                   
    SP3:                                                                                                                                                      
    SP4:        -     -     -     -                                                                                                                           
    SP5:                                                                                -                 -     -     -                                       


    ECgene alternative splicing isoforms for OXR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OXR1 expression in normal human tissues (normalized intensities)      OXR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGACAGTGAC
    OXR1 Expression
    About this image


    OXR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/30 selected tissues (see all 30) fully expand
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             bronchus ; respiratory epithelial cells   
             trachea   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   

    See OXR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OXR1

    SOURCE GeneReport for Unigene clusters: Hs.127286 Hs.701892
        SABiosciences Expression via Pathway-Focused PCR Arrays including OXR1: 
              Oxidative Stress in human mouse rat
              Nitric Oxide Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for OXR1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OXR1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OXR1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OXR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for OXR1 gene from 8/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oxr11 , 5 oxidation resistance 11, 5 83.21(n)1
    83.86(a)1
      15 (16.06 cM)5
    1707191  NM_001130165.11  NP_001123637.11 
     414474825 
    chicken
    (Gallus gallus)
    Aves OXR11 oxidation resistance 1 74.07(n)
    74.39(a)
      420270  XM_418381.3  XP_418381.3 
    lizard
    (Anolis carolinensis)
    Reptilia OXR16
    oxidation resistance 1
    69(a)
    1 ↔ 1
    4(12016877-12288056)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.161332 Xenopus laevis transcribed sequence with moderate similarity more 82.07(n)    BJ620127.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wu:fb25h121 wu:fb25h12 64.9(n)
    67.07(a)
      571418  NM_001114444.1  NP_001107916.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mtd6
    mustard
    18(a)
    possible ortholog
    3R(1095838-1176165)
    worm
    (Caenorhabditis elegans)
    Secernentea F52E1.13c3   -- 37(a)
    (best of 3)
      V(8418775-8436903)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes OXR16
    Protein of unknown function required for normal le...
    24(a)
    1 → many
    XVI(175043-175864)


    ENSEMBL Gene Tree for OXR1 (if available)
    TreeFam Gene Tree for OXR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OXR1 gene
    TLDC12  NCOA72  TLDC22  
    8 SIMAP similar genes for OXR1 using alignment to 7 protein entries:     OXR1_HUMAN (see all proteins):
    TLDC2    C20orf118    NCOA7    TBC1D24    DKFZp451P0217    TLDC1
    DKFZp761B2210    Nbla00052

    OXR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for OXR1
    PGOHUM00000247110


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8740 SNPs in OXR1 are shown (see all 8740)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344255941,2
    C--102940010(+) GCTAA-/TTTTTT 3 -- int10--------
    rs713070801,2
    C--102979907(+) TCGCT-/ATGTTGG 3 -- int11Minor allele frequency- AT:0.00NA 2
    rs1152684861,2
    C,F--107280473(+) TTTTCA/TCCTTC 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1489815681,2
    --107280495(+) ATAGAA/TAGGAA 2 -- us2k10--------
    rs796722871,2
    --107280638(+) AAAGTA/GAAAGA 2 -- us2k11Minor allele frequency- G:0.01EA 120
    rs762051381,2
    C,F--107280645(+) AAGATC/AAAACC 2 -- us2k12Minor allele frequency- A:0.07CSA WA 120
    rs1897493081,2
    --107280698(+) CAAGTA/GGGGAT 2 -- us2k10--------
    rs1813329931,2
    --107280858(+) TCACAA/GAGTCT 2 -- us2k10--------
    rs1859599751,2
    --107280937(+) TTCTGA/GTAGAA 2 -- us2k10--------
    rs2022375401,2
    --107281345(+) TACCT-/CTTA  
            
    CTTTA
    2 -- us2k10--------

    HapMap Linkage Disequilibrium report for OXR1 (107282406 - 107532406 bp, first 250kb of OXR1)

    Structural Variations
         Database of Genomic Variants (DGV) 10/39 variations for OXR1 (see all 39):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2737403CNV Deletion23290073
    esv1172684CNV Deletion17803354
    esv2737400CNV Deletion23290073
    esv2838CNV Deletion18987735
    esv2497761CNV Deletion19546169
    esv2646049CNV Deletion19546169
    esv2737401CNV Deletion23290073
    esv2602152CNV Deletion19546169
    esv2283630CNV Deletion18987734
    esv2737404CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing OXR1
    DNA2.0 Custom Variant and Variant Library Synthesis for OXR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605609    OMIM disorders: --

    2 diseases for OXR1:    About MalaCards
    neuroblastoma    breast cancer


    OXR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OXR1
    Human Genome Epidemiology (HuGE) Navigator: OXR1 (1 document)

    Export disorders for OXR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OXR1 gene, integrated from 9 sources (see all 24):
    (articles sorted by number of sources associating them with OXR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Functional genomics reveals a family of eukaryotic oxidation protection genes. (PubMed id 11114193)1, 2, 3 Volkert M.R.... Housman D.E. (2000)
    2. Structural/functional analysis of the human OXR1 protein: identification of exon 8 as the anti-oxidant encoding function. (PubMed id 22873401)1, 2 Murphy K.C. and Volkert M.R. (2012)
    3. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. Stress induction and mitochondrial localization of Oxr1 proteins in yeast and humans. (PubMed id 15060142)1, 2 Elliott N.A. and Volkert M.R. (2004)
    8. Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma. (PubMed id 12880961)1, 2 Ohira M.... Nakagawara A. (2003)
    9. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    10. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55074 HGNC: 15822 AceView: OXR1 Ensembl:ENSG00000164830 euGenes: HUgn55074
    ECgene: OXR1 H-InvDB: OXR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OXR1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/oxr1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OXR1 gene:
    Search GeneIP for patents involving OXR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for OXR1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for OXR1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for OXR1  
     OriGene qSTAR qPCR primer pairs in human, mouse for OXR1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for OXR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OXR1   OriGene Custom Protein Services for OXR1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OXR1
     QIAGEN SeqTarget long-range PCR primers for resequencing OXR1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OXR1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OXR1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OXR1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OXR1
     GenScript Custom Purified and Recombinant Proteins Services for OXR1 GenScript cDNA clones with any tag delivered in your preferred vector for OXR1
     GenScript Custom Assay Services for OXR1 GenScript Custom Superior Antibodies Services for OXR1
     GenScript Custom overexpressing Cell Line Services for OXR1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in OXR1 promoter
     Search Chromatin IP Primers for OXR1
     RT2 qPCR Primer Assay in human, mouse, rat OXR1
     Search GNC Networks for OXR1
     SABiosciences PCR Arrays including human, mouse, rat OXR1
     Search Tocris compounds for OXR1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     OXR1 antibodies
     OXR1 lysates
     Antibodies for OXR1
     See all of Abcam's Antibodies, Kits and Proteins for OXR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for OXR1
     Antibodies for OXR1
     ELISAs for OXR1
     CLIAs for OXR1
     Search LifeMap BioReagents cell lines for OXR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXR1
     SwitchGear 3'UTR luciferase reporter plasmids for OXR1
     SwitchGear Promoter luciferase reporter plasmids for OXR1
     ThermoFisher Antibodies for OXR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXR1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for OXR1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OXR1
    Customized:
     lentivirus for stable overexpression of OXR1
     lentivirus expression plasmids for stable overexpression of OXR1
     adenovirus for overexpression of OXR1
     LSBio Antibodies in human, mouse, rat for OXR1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OXR1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4