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Aliases for OXR1 Gene

Aliases for OXR1 Gene

  • Oxidation Resistance 1 2 3 5
  • TBC/LysM-Associated Domain Containing 3 2 3
  • Putative Protein Product Of Nbla00307 3
  • Nbla00307 3
  • TLDC3 3

External Ids for OXR1 Gene

Previous GeneCards Identifiers for OXR1 Gene

  • GC08P106704
  • GC08P107697
  • GC08P107299
  • GC08P107586
  • GC08P107626
  • GC08P107699
  • GC08P107282
  • GC08P102604

Summaries for OXR1 Gene

GeneCards Summary for OXR1 Gene

OXR1 (Oxidation Resistance 1) is a Protein Coding gene. Diseases associated with OXR1 include Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is NCOA7.

UniProtKB/Swiss-Prot for OXR1 Gene

  • May be involved in protection from oxidative damage.

Gene Wiki entry for OXR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXR1 Gene

Genomics for OXR1 Gene

Regulatory Elements for OXR1 Gene

Enhancers for OXR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OXR1 on UCSC Golden Path with GeneCards custom track

Promoters for OXR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OXR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OXR1 Gene

Chromosome:
8
Start:
106,270,178 bp from pter
End:
106,752,694 bp from pter
Size:
482,517 bases
Orientation:
Plus strand

Genomic View for OXR1 Gene

Genes around OXR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OXR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OXR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXR1 Gene

Proteins for OXR1 Gene

  • Protein details for OXR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N573-OXR1_HUMAN
    Recommended name:
    Oxidation resistance protein 1
    Protein Accession:
    Q8N573
    Secondary Accessions:
    • A6NK11
    • A8KA34
    • B3KXL1
    • B7Z402
    • B7Z8N5
    • D3HIS6
    • Q3LIB5
    • Q6ZVK9
    • Q8N8V0
    • Q9H266
    • Q9NWC7

    Protein attributes for OXR1 Gene

    Size:
    874 amino acids
    Molecular mass:
    97970 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG25715.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH32710.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAY26396.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA91456.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAF85588.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI46186.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for OXR1 Gene

neXtProt entry for OXR1 Gene

Proteomics data for OXR1 Gene at MOPED

Post-translational modifications for OXR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for OXR1

No data available for DME Specific Peptides for OXR1 Gene

Domains & Families for OXR1 Gene

Protein Domains for OXR1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N573

UniProtKB/Swiss-Prot:

OXR1_HUMAN :
  • Contains 1 GRAM domain.
  • Belongs to the OXR1 family.
Domain:
  • Contains 1 GRAM domain.
  • Contains 1 LysM domain.
  • Contains 1 TLD domain.
Family:
  • Belongs to the OXR1 family.
genes like me logo Genes that share domains with OXR1: view

No data available for Gene Families for OXR1 Gene

Function for OXR1 Gene

Molecular function for OXR1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in protection from oxidative damage.
UniProtKB/Swiss-Prot Induction:
By heat shock and oxidative stress.
genes like me logo Genes that share phenotypes with OXR1: view

Animal Models for OXR1 Gene

MGI Knock Outs for OXR1:
  • Oxr1 tm1a(EUCOMM)Wtsi

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OXR1 Gene

Localization for OXR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXR1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OXR1 Gene COMPARTMENTS Subcellular localization image for OXR1 gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for OXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with OXR1: view

Pathways & Interactions for OXR1 Gene

SuperPathways for OXR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress NAS 11114193
GO:0007628 adult walking behavior IEA --
GO:0043524 negative regulation of neuron apoptotic process IEA --
GO:0071447 cellular response to hydroperoxide IEA --
genes like me logo Genes that share ontologies with OXR1: view

No data available for Pathways by source and SIGNOR curated interactions for OXR1 Gene

Drugs & Compounds for OXR1 Gene

No Compound Related Data Available

Transcripts for OXR1 Gene

Unigene Clusters for OXR1 Gene

Oxidation resistance 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OXR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - - -
SP2: - -
SP3:
SP4: - - - -
SP5: - - - -
SP6: -
SP7: - - - - - - - - - - - - -
SP8: -

Relevant External Links for OXR1 Gene

GeneLoc Exon Structure for
OXR1
ECgene alternative splicing isoforms for
OXR1

Expression for OXR1 Gene

mRNA expression in normal human tissues for OXR1 Gene

Protein differential expression in normal tissues from HIPED for OXR1 Gene

This gene is overexpressed in Frontal cortex (19.6), Brain (16.4), and Heart (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OXR1 Gene



SOURCE GeneReport for Unigene cluster for OXR1 Gene Hs.127286

genes like me logo Genes that share expression patterns with OXR1: view

Protein tissue co-expression partners for OXR1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OXR1 Gene

Orthologs for OXR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OXR1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia OXR1 35
  • 91.73 (n)
  • 91.04 (a)
OXR1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oxr1 35
  • 84.49 (n)
  • 85.3 (a)
Oxr1 16
Oxr1 36
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OXR1 35
  • 99.35 (n)
  • 99.19 (a)
OXR1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oxr1 35
  • 84.31 (n)
  • 86.22 (a)
cow
(Bos Taurus)
Mammalia OXR1 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OXR1 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OXR1 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves OXR1 35
  • 74.84 (n)
  • 75.14 (a)
OXR1 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OXR1 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oxr1 35
  • 71.07 (n)
  • 71.89 (a)
Str.9341 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.16133 35
zebrafish
(Danio rerio)
Actinopterygii oxr1a 35
  • 65.6 (n)
  • 67.49 (a)
OXR1 (3 of 3) 36
  • 79 (a)
OneToMany
oxr1a 36
  • 62 (a)
OneToMany
oxr1b 36
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F52E1.13a 37
  • 37 (a)
F52E1.13b 37
  • 37 (a)
F52E1.13c 37
  • 37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10480 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7690 36
  • 33 (a)
OneToOne
Species with no ortholog for OXR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OXR1 Gene

ENSEMBL:
Gene Tree for OXR1 (if available)
TreeFam:
Gene Tree for OXR1 (if available)

Paralogs for OXR1 Gene

Paralogs for OXR1 Gene

Pseudogenes.org Pseudogenes for OXR1 Gene

genes like me logo Genes that share paralogs with OXR1: view

Variants for OXR1 Gene

Sequence variations from dbSNP and Humsavar for OXR1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs28921397 - 106,679,285(+) TATTG(A/G)GTATA reference, missense, utr-variant-5-prime
rs28921419 - 106,706,597(+) GCGAC(A/C)AGATA reference, missense
rs28921420 - 106,707,065(+) AACTA(A/G)ACAGC reference, missense
rs2022966 -- 106,438,142(-) CACAA(A/C)GAGAT intron-variant
rs2022967 -- 106,452,846(-) GCCTA(C/T)GTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OXR1 Gene

Variant ID Type Subtype PubMed ID
esv29304 CNV Loss 19812545
esv259431 OTHER Complex 20981092
esv2659632 CNV Deletion 23128226
nsv824701 CNV Loss 20364138
esv2672249 CNV Deletion 23128226
esv2737399 CNV Deletion 23290073
esv2737400 CNV Deletion 23290073
nsv397388 CNV Loss 16902084
esv270833 CNV Insertion 20981092
esv2456389 CNV Insertion 19546169
esv269507 CNV Insertion 20981092
esv2678972 CNV Deletion 23128226
dgv467n21 CNV Loss 19592680
esv2602152 CNV Deletion 19546169
esv2421125 CNV Deletion 18987734
esv1172684 CNV Deletion 17803354
esv2737401 CNV Deletion 23290073
esv5529 CNV Loss 19470904
nsv396328 CNV Loss 16902084
esv2646049 CNV Deletion 19546169
esv25447 CNV Gain 19812545
esv2737402 CNV Deletion 23290073
esv2283630 CNV Deletion 18987734
esv2737403 CNV Deletion 23290073
nsv396739 CNV Loss 16902084
esv988911 CNV Deletion 20482838
nsv396629 CNV Loss 16902084
esv26205 CNV Gain 19812545
nsv831419 CNV Loss 17160897
esv33830 CNV Loss 17666407
nsv6342 CNV Loss 18451855
esv268710 CNV Insertion 20981092
esv2497761 CNV Deletion 19546169
esv2178363 CNV Deletion 18987734
esv2838 CNV Deletion 18987735
esv2737404 CNV Deletion 23290073
esv5816 CNV Loss 19470904
esv1610500 CNV Deletion 17803354
nsv397838 CNV Loss 16902084

Variation tolerance for OXR1 Gene

Residual Variation Intolerance Score: 7.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.53% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OXR1 Gene

Disorders for OXR1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for OXR1 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards
Search OXR1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for OXR1

Genetic Association Database (GAD)
OXR1
Human Genome Epidemiology (HuGE) Navigator
OXR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OXR1
genes like me logo Genes that share disorders with OXR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for OXR1 Gene

Publications for OXR1 Gene

  1. Functional genomics reveals a family of eukaryotic oxidation protection genes. (PMID: 11114193) Volkert M.R. … Housman D.E. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 67
  2. Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations. (PMID: 25792726) Finelli M.J. … Davies K.E. (Hum. Mol. Genet. 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. Human OXR1 maintains mitochondrial DNA integrity and counteracts hydrogen peroxide-induced oxidative stress by regulating antioxidant pathways involving p21. (PMID: 25236744) Yang M. … rAYs M. (Free Radic. Biol. Med. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for OXR1 Gene

Sources for OXR1 Gene

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