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Aliases for OXR1 Gene

Aliases for OXR1 Gene

  • Oxidation Resistance 1 2 3 5
  • TBC/LysM-Associated Domain Containing 3 2 3
  • Putative Protein Product Of Nbla00307 3
  • Oxidation Resistance Protein 1 3
  • Nbla00307 3
  • TLDC3 3

External Ids for OXR1 Gene

Previous GeneCards Identifiers for OXR1 Gene

  • GC08P106704
  • GC08P107697
  • GC08P107299
  • GC08P107586
  • GC08P107626
  • GC08P107699
  • GC08P107282
  • GC08P102604

Summaries for OXR1 Gene

GeneCards Summary for OXR1 Gene

OXR1 (Oxidation Resistance 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity. An important paralog of this gene is NCOA7.

UniProtKB/Swiss-Prot for OXR1 Gene

  • May be involved in protection from oxidative damage.

Gene Wiki entry for OXR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXR1 Gene

Genomics for OXR1 Gene

Regulatory Elements for OXR1 Gene

Enhancers for OXR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around OXR1 on UCSC Golden Path with GeneCards custom track

Promoters for OXR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OXR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OXR1 Gene

Chromosome:
8
Start:
106,270,178 bp from pter
End:
106,752,694 bp from pter
Size:
482,517 bases
Orientation:
Plus strand

Genomic View for OXR1 Gene

Genes around OXR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OXR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OXR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXR1 Gene

Proteins for OXR1 Gene

  • Protein details for OXR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N573-OXR1_HUMAN
    Recommended name:
    Oxidation resistance protein 1
    Protein Accession:
    Q8N573
    Secondary Accessions:
    • A6NK11
    • A8KA34
    • B3KXL1
    • B7Z402
    • B7Z8N5
    • D3HIS6
    • Q3LIB5
    • Q6ZVK9
    • Q8N8V0
    • Q9H266
    • Q9NWC7

    Protein attributes for OXR1 Gene

    Size:
    874 amino acids
    Molecular mass:
    97970 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG25715.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH32710.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAY26396.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA91456.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAF85588.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI46186.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for OXR1 Gene

neXtProt entry for OXR1 Gene

Post-translational modifications for OXR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OXR1 Gene

Domains & Families for OXR1 Gene

Protein Domains for OXR1 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8N573

UniProtKB/Swiss-Prot:

OXR1_HUMAN :
  • Contains 1 GRAM domain.
  • Belongs to the OXR1 family.
Domain:
  • Contains 1 GRAM domain.
  • Contains 1 LysM domain.
  • Contains 1 TLD domain.
Family:
  • Belongs to the OXR1 family.
genes like me logo Genes that share domains with OXR1: view

No data available for Gene Families for OXR1 Gene

Function for OXR1 Gene

Molecular function for OXR1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in protection from oxidative damage.
UniProtKB/Swiss-Prot Induction:
By heat shock and oxidative stress.

Gene Ontology (GO) - Molecular Function for OXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016491 oxidoreductase activity IEA --
genes like me logo Genes that share ontologies with OXR1: view
genes like me logo Genes that share phenotypes with OXR1: view

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OXR1 Gene

Localization for OXR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXR1 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OXR1 Gene COMPARTMENTS Subcellular localization image for OXR1 gene
Compartment Confidence
mitochondrion 4
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for OXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005730 nucleolus IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with OXR1: view

Pathways & Interactions for OXR1 Gene

SuperPathways for OXR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006979 response to oxidative stress NAS 11114193
GO:0007628 adult walking behavior IEA --
GO:0043524 negative regulation of neuron apoptotic process IEA --
GO:0055114 oxidation-reduction process IEA --
GO:0071447 cellular response to hydroperoxide IEA --
genes like me logo Genes that share ontologies with OXR1: view

No data available for Pathways by source and SIGNOR curated interactions for OXR1 Gene

Drugs & Compounds for OXR1 Gene

No Compound Related Data Available

Transcripts for OXR1 Gene

Unigene Clusters for OXR1 Gene

Oxidation resistance 1:
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OXR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b · 17c
SP1: - - -
SP2: - -
SP3:
SP4: - - - -
SP5: - - - -
SP6: -
SP7: - - - - - - - - - - - - -
SP8: -

Relevant External Links for OXR1 Gene

GeneLoc Exon Structure for
OXR1
ECgene alternative splicing isoforms for
OXR1

Expression for OXR1 Gene

mRNA expression in normal human tissues for OXR1 Gene

Protein differential expression in normal tissues from HIPED for OXR1 Gene

This gene is overexpressed in Frontal cortex (19.6), Brain (16.4), and Heart (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OXR1 Gene



Protein tissue co-expression partners for OXR1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of OXR1 Gene:

OXR1

SOURCE GeneReport for Unigene cluster for OXR1 Gene:

Hs.127286
genes like me logo Genes that share expression patterns with OXR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OXR1 Gene

Orthologs for OXR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OXR1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia OXR1 34
  • 91.73 (n)
  • 91.04 (a)
OXR1 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Oxr1 34
  • 84.49 (n)
  • 85.3 (a)
Oxr1 16
Oxr1 35
  • 83 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OXR1 34
  • 99.35 (n)
  • 99.19 (a)
OXR1 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Oxr1 34
  • 84.31 (n)
  • 86.22 (a)
cow
(Bos Taurus)
Mammalia OXR1 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OXR1 35
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OXR1 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves OXR1 34
  • 74.84 (n)
  • 75.14 (a)
OXR1 35
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OXR1 35
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oxr1 34
  • 71.07 (n)
  • 71.89 (a)
Str.9341 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.16133 34
zebrafish
(Danio rerio)
Actinopterygii oxr1a 34
  • 65.6 (n)
  • 67.49 (a)
OXR1 (3 of 3) 35
  • 79 (a)
OneToMany
oxr1a 35
  • 62 (a)
OneToMany
oxr1b 35
  • 61 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F52E1.13a 36
  • 37 (a)
F52E1.13b 36
  • 37 (a)
F52E1.13c 36
  • 37 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.10480 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7690 35
  • 33 (a)
OneToOne
Species where no ortholog for OXR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OXR1 Gene

ENSEMBL:
Gene Tree for OXR1 (if available)
TreeFam:
Gene Tree for OXR1 (if available)

Paralogs for OXR1 Gene

Paralogs for OXR1 Gene

Pseudogenes.org Pseudogenes for OXR1 Gene

genes like me logo Genes that share paralogs with OXR1: view

Variants for OXR1 Gene

Sequence variations from dbSNP and Humsavar for OXR1 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs28921397 - 106,679,285(+) TATTG(A/G)GTATA reference, missense, utr-variant-5-prime
rs28921419 - 106,706,597(+) GCGAC(A/C)AGATA reference, missense
rs28921420 - 106,707,065(+) AACTA(A/G)ACAGC reference, missense
rs965157 -- 106,482,674(+) TGATG(A/G)GCATC intron-variant
rs965158 -- 106,482,690(+) TCCAT(A/G)GACTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OXR1 Gene

Variant ID Type Subtype PubMed ID
dgv3874n106 CNV deletion 24896259
dgv3875n106 CNV deletion 24896259
dgv467n21 CNV loss 19592680
esv1172684 CNV deletion 17803354
esv1610500 CNV deletion 17803354
esv2178363 CNV deletion 18987734
esv2283630 CNV deletion 18987734
esv2421125 CNV deletion 18987734
esv2456389 CNV insertion 19546169
esv2497761 CNV deletion 19546169
esv25447 CNV gain 19812545
esv2602152 CNV deletion 19546169
esv26205 CNV gain 19812545
esv2646049 CNV deletion 19546169
esv2659632 CNV deletion 23128226
esv2672249 CNV deletion 23128226
esv2678972 CNV deletion 23128226
esv2737399 CNV deletion 23290073
esv2737400 CNV deletion 23290073
esv2737401 CNV deletion 23290073
esv2737402 CNV deletion 23290073
esv2737403 CNV deletion 23290073
esv2737404 CNV deletion 23290073
esv2838 CNV loss 18987735
esv29304 CNV loss 19812545
esv3302457 CNV tandem duplication 20981092
esv3304432 CNV mobile element insertion 20981092
esv3305229 CNV mobile element insertion 20981092
esv3306557 CNV mobile element insertion 20981092
esv3365556 CNV insertion 20981092
esv3370976 CNV insertion 20981092
esv3377584 CNV insertion 20981092
esv33830 CNV loss 17666407
esv3390747 CNV duplication 20981092
esv3421726 CNV insertion 20981092
esv3543969 CNV deletion 23714750
esv3543971 CNV deletion 23714750
esv3618305 CNV loss 21293372
esv3618306 CNV loss 21293372
esv3618309 CNV loss 21293372
esv3618312 CNV gain 21293372
esv3618314 CNV loss 21293372
esv3618317 CNV loss 21293372
esv5529 CNV loss 19470904
esv5816 CNV loss 19470904
esv988911 CNV deletion 20482838
nsv1032991 CNV gain 25217958
nsv1075161 CNV deletion 25765185
nsv1075162 CNV deletion 25765185
nsv1143371 CNV deletion 24896259
nsv1146099 CNV deletion 26484159
nsv396328 CNV deletion 16902084
nsv396629 CNV deletion 16902084
nsv396739 CNV deletion 16902084
nsv397388 CNV deletion 16902084
nsv397838 CNV deletion 16902084
nsv472028 CNV novel sequence insertion 20440878
nsv611844 CNV loss 21841781
nsv611845 CNV loss 21841781
nsv6342 CNV deletion 18451855
nsv824701 CNV loss 20364138
nsv831419 CNV loss 17160897
nsv956030 CNV deletion 24416366
nsv957686 CNV deletion 24416366
nsv971345 CNV duplication 23825009
nsv971692 CNV duplication 23825009
nsv981973 CNV duplication 23825009

Variation tolerance for OXR1 Gene

Residual Variation Intolerance Score: 7.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.26; 40.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OXR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OXR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXR1 Gene

Disorders for OXR1 Gene

Relevant External Links for OXR1

Genetic Association Database (GAD)
OXR1
Human Genome Epidemiology (HuGE) Navigator
OXR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OXR1

No disorders were found for OXR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OXR1 Gene

Publications for OXR1 Gene

  1. Functional genomics reveals a family of eukaryotic oxidation protection genes. (PMID: 11114193) Volkert M.R. … Housman D.E. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 65
  2. Structural/functional analysis of the human OXR1 protein: identification of exon 8 as the anti-oxidant encoding function. (PMID: 22873401) Murphy K.C. … Volkert M.R. (BMC Mol. Biol. 2012) 3 4 65
  3. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 65
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 65
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65

Products for OXR1 Gene

Sources for OXR1 Gene

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