OXNAD1 Gene
protein-coding GIFtS: 43
GCID: GC03P016282
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oxidoreductase NAD-binding domain containing 1
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Aliases
for OXNAD1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Oxidoreductase NAD-Binding Domain Containing 11 2 | | MGC157631 | | Oxidoreductase NAD-Binding Domain-Containing Protein 12 | | EC 1.-.-.-3 |
Export aliases for OXNAD1 gene to outside databases |
Summaries
for OXNAD1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for OXNAD1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_022517.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OXNAD1 gene promoter:
Pbx1a HTF E47 AREB6 CREB E2F E2F-1 deltaCREB FOXJ2 (long isoform) FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for OXNAD1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OXNAD1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p25-p24 Ensembl cytogenetic band: 3p25.1 HGNC cytogenetic band: 3p25-p24OXNAD1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P016282: view genomic region
(about GC identifiers)
Start:
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16,306,667 bp from pter |
End:
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16,378,822 bp from pter |
Size:
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72,156 bases |
Orientation:
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plus strand |
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Proteins
for OXNAD1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OXND1_HUMAN, Q96HP4 (See
protein sequence)Recommended Name: Oxidoreductase NAD-binding domain-containing protein 1 precursor Size: 312 amino acids; 34854 Da
Secondary accessions: Q2HYC7 Q59FA4Explore the universe of human proteins at neXtProt for OXNAD1: NX_Q96HP4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96HP4
OXNAD1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612390.1
ENSEMBL proteins: ENSP00000285083 ENSP00000398867 ENSP00000389872 ENSP00000397374 ENSP00000437967
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005739 | mitochondrion |
IEA | -- |
OXNAD1 for ontologies About GeneDecksing
OXNAD1 Antibody Products:
Assay Products for OXNAD1: |
Protein
Domains /
Families
for OXNAD1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OXNAD1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96HP4ProtoNet protein and cluster: Q96HP4 1 Blocks protein family: IPB001433 Oxidoreductase FAD/NAD(P)-binding
UniProtKB/Swiss-Prot: OXND1_HUMAN, Q96HP4Similarity: Contains 1 FAD-binding FR-type domain |
Function
for OXNAD1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Enzyme Number (IUBMB): EC 1.-.-.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OXNAD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OXNAD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: OXNAD1 (NM_138381) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OXNAD1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXNAD1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXNAD1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016491 | oxidoreductase activity |
IEA | -- |
OXNAD1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for OXNAD1:
Animal Models:
1 MGI phenotypic allele  for Oxnad1 (no phenotypes)
OXNAD1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for OXNAD1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OXNAD1
|
Drugs & Compounds
for OXNAD1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for OXNAD1
1 HMDB Compound for OXNAD1 About this table
| Compound | Synonyms |
CAS
# | PubMed Ids |
|---|
| FAD | 1H-Purin-6-amine flavin dinucleotide (see all 21) | 146-14-5 | -- |
Search CenterWatch for drugs/clinical trials and news about OXNAD1 / OXND1
|
Transcripts
for OXNAD1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for OXNAD1 gene: NM_138381.3 Unigene Cluster for OXNAD1: Oxidoreductase NAD-binding domain containing 1 Hs.655449 [show with all ESTs]Unigene Representative Sequence: NM_1383816 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000285083(uc010her.2 uc003caw.3 uc003cax.3) ENST00000442255
ENST00000435829 ENST00000486267 ENST00000452581 ENST00000544043(uc011awb.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OXNAD1 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OXNAD1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: OXNAD1 (NM_138381) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for OXNAD1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXNAD1 |
Additional cDNA sequence: AB209556.1 AK298829.1 AK307258.1 AL832787.1 BC007285.1 BC008322.1 BC018770.1 DQ364598.1 7 DOTS entries: DT.108593 DT.100812834 DT.100707404 DT.95373131 DT.91811449 DT.92044244 DT.120899654 24/83 AceView cDNA sequences (see all 83): BC007285 CR614426 AA558453 CR616590 BC018770 BU621257 BQ771797 BM818310 BE018369 BQ180851 CR610840 AL514296 BC008322 NM_138381 BU633011 AI364281 CR603194 BX097377 BX487275 BX343102 BE465433 BE891159 AI991563 BE301983
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for OXNAD1 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 |
|---|
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| SP1: | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for OXNAD1
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Expression
for OXNAD1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| OXNAD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACCCAAAGA
About this image
See OXNAD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OXNAD1
SOURCE GeneReport for Unigene cluster: Hs.655449
SABiosciences Custom PCR Arrays for OXNAD1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OXNAD1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat OXNAD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OXNAD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OXNAD1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXNAD1 |
Orthologs
for OXNAD1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for OXNAD1 gene from 5/17 species (see all 17) About this table
ENSEMBL Gene Tree for OXNAD1 (if available)
TreeFam Gene Tree for OXNAD1 (if available) |
Paralogs
for OXNAD1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for OXNAD1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for OXNAD1 (16306667 - 16378822 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OXNAD1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OXNAD1 |
|
Disorders
/ Diseases
for OXNAD1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 OXNAD1 for disorders About MalaCards
OXNAD1 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: OXNAD1 (1 document)
Export disorders for OXNAD1 gene to outside databases
|
Publications
for OXNAD1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for OXNAD1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OXNAD1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for OXNAD1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OXNAD1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OXNAD1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OXNAD1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for OXNAD1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for OXNAD1 gene:
Search GeneIP for patents involving OXNAD1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OXNAD1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for OXNAD1 | | OriGene shRNA RFP for OXNAD1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for OXNAD1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for OXNAD1 | | | OriGene Protein Over-expression Lysate for OXNAD1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for OXNAD1 | | OriGene 3'-UTR Clone for OXNAD1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for OXNAD1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for OXNAD1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for OXNAD1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for OXNAD1 | | OriGene Custom Protein Services for OXNAD1 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat OXNAD1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing OXNAD1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OXNAD1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat OXNAD1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat OXNAD1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat OXNAD1 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for OXNAD1 |
| |  |  |  |  | | | | |
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 | | | OXNAD1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXNAD1 |
|  |  |  | | | | Search ThermoFisher Antibodies for OXNAD1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXNAD1 |
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