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Aliases for OXNAD1 Gene

Aliases for OXNAD1 Gene

  • Oxidoreductase NAD Binding Domain Containing 1 2 3 5
  • Oxidoreductase NAD-Binding Domain Containing 1 2
  • EC 1.-.-.- 4

External Ids for OXNAD1 Gene

Previous GeneCards Identifiers for OXNAD1 Gene

  • GC03P016282

Summaries for OXNAD1 Gene

GeneCards Summary for OXNAD1 Gene

OXNAD1 (Oxidoreductase NAD Binding Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXNAD1 Gene

Genomics for OXNAD1 Gene

Regulatory Elements for OXNAD1 Gene

Enhancers for OXNAD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G016507 2 FANTOM5 Ensembl ENCODE dbSUPER 15.4 +247.4 247399 9.3 HDGF PKNOX1 FOXA2 ARNT WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YBX1 RFTN1 OXNAD1 DPH3 PLCL2 GC03M015947
GH03G016298 1.9 FANTOM5 Ensembl ENCODE dbSUPER 12.1 +37.0 37037 8.2 PKNOX1 CREB3L1 ARNT E2F7 YY1 TCF12 GATA2 FOS NCOA1 TBX21 DPH3 ENSG00000271964 OXNAD1 RFTN1 ANKRD28 PIR49727 THAP5P2
GH03G016057 2 FANTOM5 Ensembl ENCODE dbSUPER 10.6 -204.7 -204660 5.4 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 SLC30A9 ZNF143 FOS GALNT15 ENSG00000270409 OXNAD1 DPH3 COLQ ANKRD28 GC03P015879
GH03G016284 1.5 Ensembl ENCODE dbSUPER 11.4 +23.2 23188 7.2 HNRNPUL1 FOXA2 ATF1 MLX ARNT ZFP64 ARID4B DMAP1 YY1 SLC30A9 DPH3 ENSG00000271964 OXNAD1 RFTN1 THAP5P2 PIR49727
GH03G016100 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -162.7 -162672 4.7 PKNOX1 FOXA2 INSM2 KLF17 FEZF1 RAD21 RCOR1 FOS RELB CREM ENSG00000270409 GALNT15 DPH3 OXNAD1 GC03P015879
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OXNAD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OXNAD1 Gene

Chromosome:
3
Start:
16,265,160 bp from pter
End:
16,386,979 bp from pter
Size:
121,820 bases
Orientation:
Plus strand

Genomic View for OXNAD1 Gene

Genes around OXNAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OXNAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OXNAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXNAD1 Gene

Proteins for OXNAD1 Gene

  • Protein details for OXNAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HP4-OXND1_HUMAN
    Recommended name:
    Oxidoreductase NAD-binding domain-containing protein 1
    Protein Accession:
    Q96HP4
    Secondary Accessions:
    • Q2HYC7
    • Q59FA4

    Protein attributes for OXNAD1 Gene

    Size:
    312 amino acids
    Molecular mass:
    34854 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OXNAD1 Gene

Post-translational modifications for OXNAD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for OXNAD1 Gene

Domains & Families for OXNAD1 Gene

Suggested Antigen Peptide Sequences for OXNAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OXNAD1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for OXNAD1 Gene

Function for OXNAD1 Gene

Enzyme Numbers (IUBMB) for OXNAD1 Gene

Gene Ontology (GO) - Molecular Function for OXNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016491 oxidoreductase activity IBA,IEA --
genes like me logo Genes that share ontologies with OXNAD1: view

Phenotypes for OXNAD1 Gene

genes like me logo Genes that share phenotypes with OXNAD1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for OXNAD1

CRISPR Products

miRNA for OXNAD1 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for OXNAD1 Gene

Localization for OXNAD1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OXNAD1 gene
Compartment Confidence
mitochondrion 4
extracellular 2
plasma membrane 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for OXNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IBA --
genes like me logo Genes that share ontologies with OXNAD1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for OXNAD1 Gene

Pathways & Interactions for OXNAD1 Gene

SuperPathways for OXNAD1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OXNAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0055114 oxidation-reduction process IEA --
genes like me logo Genes that share ontologies with OXNAD1: view

No data available for Pathways by source and SIGNOR curated interactions for OXNAD1 Gene

Drugs & Compounds for OXNAD1 Gene

(1) Drugs for OXNAD1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma 0
genes like me logo Genes that share compounds with OXNAD1: view

Transcripts for OXNAD1 Gene

Unigene Clusters for OXNAD1 Gene

Oxidoreductase NAD-binding domain containing 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OXNAD1 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10
SP1: - - -
SP2: - -
SP3:
SP4: -
SP5: -

Relevant External Links for OXNAD1 Gene

GeneLoc Exon Structure for
OXNAD1
ECgene alternative splicing isoforms for
OXNAD1

Expression for OXNAD1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OXNAD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for OXNAD1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (64.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for OXNAD1 Gene



NURSA nuclear receptor signaling pathways regulating expression of OXNAD1 Gene:

OXNAD1

SOURCE GeneReport for Unigene cluster for OXNAD1 Gene:

Hs.655449

Evidence on tissue expression from TISSUES for OXNAD1 Gene

  • Nervous system(4.3)
  • Eye(4)
genes like me logo Genes that share expression patterns with OXNAD1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for OXNAD1 Gene

Orthologs for OXNAD1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OXNAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OXNAD1 34 35
  • 99.47 (n)
dog
(Canis familiaris)
Mammalia OXNAD1 34 35
  • 90.49 (n)
mouse
(Mus musculus)
Mammalia Oxnad1 34 16 35
  • 84.31 (n)
rat
(Rattus norvegicus)
Mammalia Oxnad1 34
  • 83.17 (n)
cow
(Bos Taurus)
Mammalia OXNAD1 34 35
  • 82.74 (n)
oppossum
(Monodelphis domestica)
Mammalia OXNAD1 35
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OXNAD1 35
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves OXNAD1 34 35
  • 68.15 (n)
lizard
(Anolis carolinensis)
Reptilia OXNAD1 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia oxnad1 34
  • 64.13 (n)
Str.14109 34
African clawed frog
(Xenopus laevis)
Amphibia MGC68903 34
zebrafish
(Danio rerio)
Actinopterygii oxnad1 34 35
  • 60.72 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.129 35
  • 38 (a)
OneToOne
Species where no ortholog for OXNAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OXNAD1 Gene

ENSEMBL:
Gene Tree for OXNAD1 (if available)
TreeFam:
Gene Tree for OXNAD1 (if available)

Paralogs for OXNAD1 Gene

No data available for Paralogs for OXNAD1 Gene

Variants for OXNAD1 Gene

Sequence variations from dbSNP and Humsavar for OXNAD1 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000039465 -- 16,348,614(+) CTTCC(A/C/T)GAGGC intron-variant, utr-variant-3-prime
rs1000040207 -- 16,308,515(+) GATGA(A/T)CTGAT intron-variant
rs1000042990 -- 16,339,118(+) AGGAA(A/G)GGATT intron-variant, utr-variant-3-prime
rs1000053416 -- 16,307,466(+) AGGAC(A/G)GGAAA intron-variant
rs1000115835 -- 16,338,875(+) GTCTG(C/T)AGGAA intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OXNAD1 Gene

Variant ID Type Subtype PubMed ID
esv3595402 CNV loss 21293372

Variation tolerance for OXNAD1 Gene

Residual Variation Intolerance Score: 92.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.16; 96.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OXNAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OXNAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXNAD1 Gene

Disorders for OXNAD1 Gene

Relevant External Links for OXNAD1

Genetic Association Database (GAD)
OXNAD1
Human Genome Epidemiology (HuGE) Navigator
OXNAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OXNAD1

No disorders were found for OXNAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OXNAD1 Gene

Publications for OXNAD1 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for OXNAD1 Gene

Sources for OXNAD1 Gene

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