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Aliases for OXGR1 Gene

Aliases for OXGR1 Gene

  • Oxoglutarate Receptor 1 2 3
  • Oxoglutarate (Alpha-Ketoglutarate) Receptor 1 2 3 5
  • Alpha-Ketoglutarate Receptor 1 2 3 4
  • G Protein-Coupled Receptor 80 2 3
  • G-Protein Coupled Receptor 80 3 4
  • G-Protein Coupled Receptor 99 3 4
  • P2Y-Like Nucleotide Receptor 3 4
  • P2Y Purinoceptor 15 3 4
  • P2Y-Like GPCR 3 4
  • P2RY15 3 4
  • GPR80 3 4
  • GPR99 3 4
  • P2Y15 3 4
  • Seven Transmembrane Helix Receptor 3
  • G Protein-Coupled Receptor 99 3
  • 2-Oxoglutarate Receptor 1 2
  • AKGR 3

External Ids for OXGR1 Gene

Previous HGNC Symbols for OXGR1 Gene

  • GPR99
  • GPR80

Previous GeneCards Identifiers for OXGR1 Gene

  • GC13M096435
  • GC13M097637
  • GC13M078234

Summaries for OXGR1 Gene

GeneCards Summary for OXGR1 Gene

OXGR1 (Oxoglutarate Receptor 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is P2RY2.

UniProtKB/Swiss-Prot for OXGR1 Gene

  • Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity).

Gene Wiki entry for OXGR1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXGR1 Gene

Genomics for OXGR1 Gene

Regulatory Elements for OXGR1 Gene

Enhancers for OXGR1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OXGR1 on UCSC Golden Path with GeneCards custom track

Promoters for OXGR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OXGR1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OXGR1 Gene

96,985,719 bp from pter
96,995,826 bp from pter
10,108 bases
Minus strand

Genomic View for OXGR1 Gene

Genes around OXGR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OXGR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OXGR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXGR1 Gene

Proteins for OXGR1 Gene

  • Protein details for OXGR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    2-oxoglutarate receptor 1
    Protein Accession:
    Secondary Accessions:
    • Q5T5A7
    • Q86TL1

    Protein attributes for OXGR1 Gene

    337 amino acids
    Molecular mass:
    38251 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OXGR1 Gene

Proteomics data for OXGR1 Gene at MOPED

Post-translational modifications for OXGR1 Gene

  • Glycosylation at Asn 10, Asn 23, Asn 176, and Asn 179
  • Modification sites at PhosphoSitePlus

Other Protein References for OXGR1 Gene

No data available for DME Specific Peptides for OXGR1 Gene

Domains & Families for OXGR1 Gene

Gene Families for OXGR1 Gene

Protein Domains for OXGR1 Gene

Suggested Antigen Peptide Sequences for OXGR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the G-protein coupled receptor 1 family.
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OXGR1: view

Function for OXGR1 Gene

Molecular function for OXGR1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By similarity).
genes like me logo Genes that share phenotypes with OXGR1: view

Animal Models for OXGR1 Gene

MGI Knock Outs for OXGR1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OXGR1 Gene

Localization for OXGR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXGR1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for OXGR1 Gene COMPARTMENTS Subcellular localization image for OXGR1 gene
Compartment Confidence
plasma membrane 5
endoplasmic reticulum 2

Gene Ontology (GO) - Cellular Components for OXGR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,TAS 12098360
genes like me logo Genes that share ontologies with OXGR1: view

Pathways & Interactions for OXGR1 Gene

genes like me logo Genes that share pathways with OXGR1: view

Interacting Proteins for OXGR1 Gene

Gene Ontology (GO) - Biological Process for OXGR1 Gene


No data available for SIGNOR curated interactions for OXGR1 Gene

Drugs & Compounds for OXGR1 Gene

(2) Drugs for OXGR1 Gene - From: DGIdb and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
2-Ketobutyric acid Experimental Pharma 0

(1) Additional Compounds for OXGR1 Gene - From: IUPHAR

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
alpha-ketoglutaric acid
Full agonist, Agonist
genes like me logo Genes that share compounds with OXGR1: view

Transcripts for OXGR1 Gene

mRNA/cDNA for OXGR1 Gene

(6) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OXGR1 Gene

Oxoglutarate (alpha-ketoglutarate) receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OXGR1 Gene

No ASD Table

Relevant External Links for OXGR1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OXGR1 Gene

mRNA expression in normal human tissues for OXGR1 Gene

mRNA differential expression in normal tissues according to GTEx for OXGR1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x4.5) and Skin - Not Sun Exposed (Suprapubic) (x4.4).

SOURCE GeneReport for Unigene cluster for OXGR1 Gene Hs.352218

mRNA Expression by UniProt/SwissProt for OXGR1 Gene

Tissue specificity: Detected in kidney and, to a lower extend, in placenta. Not detected in brain tissues including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons.
genes like me logo Genes that share expression patterns with OXGR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for OXGR1 Gene

Orthologs for OXGR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OXGR1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia OXGR1 35
  • 84.08 (n)
  • 85.16 (a)
OXGR1 36
  • 85 (a)
(Canis familiaris)
Mammalia OXGR1 35
  • 88.43 (n)
  • 90.21 (a)
OXGR1 36
  • 82 (a)
(Mus musculus)
Mammalia Oxgr1 35
  • 82.79 (n)
  • 85.46 (a)
Oxgr1 16
Oxgr1 36
  • 85 (a)
(Pan troglodytes)
Mammalia OXGR1 35
  • 99.31 (n)
  • 99.7 (a)
OXGR1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Oxgr1 35
  • 82 (n)
  • 85.76 (a)
(Monodelphis domestica)
Mammalia OXGR1 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
(Gallus gallus)
Aves OXGR1 35
  • 65.08 (n)
  • 63.1 (a)
OXGR1 36
  • 62 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 52 (a)
-- 36
  • 50 (a)
(Danio rerio)
Actinopterygii oxgr1a.1 35
  • 54.63 (n)
  • 46.15 (a)
oxgr1a.1 36
  • 43 (a)
oxgr1a.2 36
  • 40 (a)
oxgr1a.3 36
  • 40 (a)
oxgr1b 36
  • 44 (a)
Species with no ortholog for OXGR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OXGR1 Gene

Gene Tree for OXGR1 (if available)
Gene Tree for OXGR1 (if available)

Paralogs for OXGR1 Gene

genes like me logo Genes that share paralogs with OXGR1: view

Variants for OXGR1 Gene

Sequence variations from dbSNP and Humsavar for OXGR1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1604445 -- 96,996,065(-) TCAGG(G/T)TTCCT upstream-variant-2KB
rs1501855 -- 96,992,948(-) AGCTT(C/G/T)GGAGC intron-variant
rs1553304 -- 96,990,028(-) agaga(C/T)gattt intron-variant
rs4771260 -- 96,997,446(+) TCCTA(A/G)CCATG upstream-variant-2KB
rs4771972 -- 96,992,657(+) TTGCC(C/T)ATTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OXGR1 Gene

Variant ID Type Subtype PubMed ID
nsv7246 OTHER Inversion 18451855
nsv832693 CNV Loss 17160897

Variation tolerance for OXGR1 Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.46% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OXGR1 Gene

Disorders for OXGR1 Gene

Relevant External Links for OXGR1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OXGR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OXGR1 Gene

Publications for OXGR1 Gene

  1. GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors. (PMID: 12098360) Wittenberger T. … Hampe W. (BMC Genomics 2002) 2 3 4 23 67
  2. Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma. (PMID: 19760608) Lu C.Y. … Chang Y.S. (Genes Chromosomes Cancer 2009) 3 23
  3. Citric acid cycle intermediates as ligands for orphan G-protein- coupled receptors. (PMID: 15141213) He W. … Ling L. (Nature 2004) 2 3
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  5. Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine. (PMID: 15001573) Inbe H. … Encinas J.A. (J. Biol. Chem. 2004) 3

Products for OXGR1 Gene

Sources for OXGR1 Gene