Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



OXGR1 Gene

protein-coding   GIFtS: 55
GCID: GC13M097637

Oxoglutarate (Alpha-Ketoglutarate) Receptor 1

(Previous name: G protein-coupled receptor 80)
(Previous symbols: GPR99, GPR80)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Oxoglutarate (Alpha-Ketoglutarate) Receptor 11 2     G-Protein Coupled Receptor 992 3
GPR801 2 3 5     P2Y Purinoceptor 152 3
GPR991 2 3     P2Y-Like GPCR2 3
G Protein-Coupled Receptor 801 2     P2Y-Like Nucleotide Receptor2 3
Alpha-Ketoglutarate Receptor 12 3     2-Oxoglutarate Receptor 12
P2RY152 3     G Protein-Coupled Receptor 992
P2Y152 3     Oxoglutarate Receptor 12
G-Protein Coupled Receptor 802 3     Seven Transmembrane Helix Receptor2

External Ids:    HGNC: 45311   Entrez Gene: 271992   Ensembl: ENSG000001656217   OMIM: 6069225   UniProtKB: Q96P683   

Export aliases for OXGR1 gene to outside databases

Previous GC identifers: GC13M096435 GC13M078234


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for OXGR1 Gene:
OXGR1 (oxoglutarate (alpha-ketoglutarate) receptor 1) is a protein-coding gene. Diseases associated with OXGR1 include hepatocellular carcinoma. GO annotations related to this gene include G-protein coupled receptor activity. An important paralog of this gene is P2RY4.

UniProtKB/Swiss-Prot: OXGR1_HUMAN, Q96P68
Function: Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By
similarity)

Gene Wiki entry for OXGR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000013.11  NT_009952.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OXGR1 gene promoter:
         C/EBPbeta   Pbx1a   AP-4   Cdc5   NF-AT   MEF-2A   aMEF-2   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOXGR1 promoter sequence
   Search Chromatin IP Primers for OXGR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OXGR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q32.1   Ensembl cytogenetic band:  13q32.1   HGNC cytogenetic band: 13q32.2

OXGR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OXGR1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M097637:  view genomic region     (about GC identifiers)

Start:
97,637,973 bp from pter      End:
97,646,984 bp from pter
Size:
9,012 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: OXGR1_HUMAN, Q96P68 (See protein sequence)
Recommended Name: 2-oxoglutarate receptor 1  
Size: 337 amino acids; 38251 Da
Caution: Was originally (Ref.5) thought to be a P2Y receptor
Secondary accessions: Q5T5A7 Q86TL1

Explore the universe of human proteins at neXtProt for OXGR1: NX_Q96P68

Explore proteomics data for OXGR1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn10, Asn23, Asn176, Asn179

  • See OXGR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_543008.3  
    ENSEMBL proteins: 
     ENSP00000298440   ENSP00000438800   ENSP00000445269   ENSP00000437356  
    Reactome Protein details: Q96P68

    OXGR1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for OXGR1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for OXGR1
    GenScript Custom Purified and Recombinant Proteins Services for OXGR1
    Novus Biologicals OXGR1 Protein
    Novus Biologicals OXGR1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OXGR1

    OXGR1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for OXGR1
    OriGene Custom Antibody Services for OXGR1
    Novus Biologicals OXGR1 Antibodies
    Abcam antibodies for OXGR1
    Cloud-Clone Corp. Antibodies for OXGR1
    ThermoFisher Antibodies for OXGR1
    LSBio Antibodies in human, mouse, rat for OXGR1

    OXGR1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OXGR1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OXGR1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OXGR1
    Cloud-Clone Corp. CLIAs for OXGR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    GPCRAO: GPCR / Class A : Orphans

    IUPHAR Guide to PHARMACOLOGY protein family classification: oxoglutarate receptor
    Oxoglutarate receptor

    2 InterPro protein domains:
     IPR017452 GPCR_Rhodpsn_7TM
     IPR000276 GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry Q96P68

    ProtoNet protein and cluster: Q96P68

    1 Blocks protein domain: IPB002286 P2 purinoceptor signature

    UniProtKB/Swiss-Prot: OXGR1_HUMAN, Q96P68
    Similarity: Belongs to the G-protein coupled receptor 1 family


    OXGR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OXGR1_HUMAN, Q96P68
    Function: Receptor for alpha-ketoglutarate. Seems to act exclusively through a G(q)-mediated pathway (By
    similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity IEA--
         
    OXGR1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Oxgr1):
     homeostasis/metabolism  immune system  renal/urinary system 

    OXGR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Oxgr1tm1(KOMP)Vlcg for OXGR1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OXGR1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OXGR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OXGR1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OXGR1

    miRNA
    Products:
        
    miRTarBase miRNAs that target OXGR1:
    hsa-mir-335-5p (MIRT018985)

    Block miRNA regulation of human, mouse, rat OXGR1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate OXGR1:
    hsa-miR-4311 hsa-miR-1323 hsa-miR-548o hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidOXGR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OXGR1
    Predesigned siRNA for gene silencing in human, mouse, rat OXGR1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OXGR1

    Clone
    Products:
         
    OriGene clones in human, mouse for OXGR1 (see all 7)
    OriGene ORF clones in mouse, rat for OXGR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OXGR1 (NM_080818)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OXGR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXGR1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OXGR1
    Browse ESI BIO Cell Lines and PureStem Progenitors for OXGR1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXGR1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    OXGR1_HUMAN, Q96P68: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    endoplasmic reticulum2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane TAS12098360

    OXGR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for OXGR1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    G alpha (i) signalling events0.44
    GPCR ligand binding0.71

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Reactome Pathways for OXGR1
        G alpha (i) signalling events
    Class A/1 (Rhodopsin-like receptors)



    OXGR1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including OXGR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for OXGR1

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007186G-protein coupled receptor signaling pathway TAS12098360

    OXGR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OXGR1

    1 HMDB Compound for OXGR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    2-Ketobutyric acid2-Ketobutanoate (see all 35)600-18-0--

    1 IUPHAR Ligand for OXGR1 (oxoglutarate receptor)    About this table
    LigandTypeActionAffinityPubmed IDs
    alpha-ketoglutaric acid
    AgonistFull agonist3.3 - 4.4923396314 15141213



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for OXGR1 gene: 
    NM_080818.3  

    Unigene Cluster for OXGR1:

    Oxoglutarate (alpha-ketoglutarate) receptor 1
    Hs.352218  [show with all ESTs]
    Unigene Representative Sequence: AK122639
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298440(uc001vmx.1 uc010afr.1) ENST00000543457 ENST00000541518
    ENST00000541038
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OXGR1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate OXGR1:
    hsa-miR-4311 hsa-miR-1323 hsa-miR-548o hsa-miR-551b*
    SwitchGear 3'UTR luciferase reporter plasmidOXGR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OXGR1
    Predesigned siRNA for gene silencing in human, mouse, rat OXGR1
    Clone
    Products:
         
    OriGene clones in human, mouse for OXGR1 (see all 7)
    OriGene ORF clones in mouse, rat for OXGR1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OXGR1 (NM_080818)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OXGR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXGR1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for OXGR1
    OriGene qSTAR qPCR primer pairs in human, mouse for OXGR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OXGR1
      QuantiTect SYBR Green Assays in human, mouse, rat OXGR1
      QuantiFast Probe-based Assays in human, mouse, rat OXGR1

    Additional mRNA sequence: 

    AF370886.1 AJ305372.1 AK122639.1 AK313684.1 BC103881.1 BC103882.1 BC103883.1 JQ308179.1 

    1 DOTS entry:

    DT.97800264 

    6 AceView cDNA sequences:

    BM723768 AK122639 NM_080818 AF370886 AJ305372 AW827323 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    OXGR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGGTACAGT
    OXGR1 Expression
    About this image

    OXGR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OXGR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.352218

    UniProtKB/Swiss-Prot: OXGR1_HUMAN, Q96P68
    Tissue specificity: Detected in kidney and, to a lower extend, in placenta. Not detected in brain tissues
    including the frontal cortex, caudate putamen, thalamus, hypothalamus, hippocampus or pons

        Pathway & Disease-focused RT2 Profiler PCR Array including OXGR1: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for OXGR1
    OriGene qSTAR qPCR primer pairs in human, mouse for OXGR1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OXGR1
    QuantiTect SYBR Green Assays in human, mouse, rat OXGR1
    QuantiFast Probe-based Assays in human, mouse, rat OXGR1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXGR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for OXGR1 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Oxgr11 , 5 oxoglutarate (alpha-ketoglutarate) receptor 11, 5 82.79(n)1
    85.46(a)1
      14 (63.63 cM)5
    2392831  NM_001001490.31  NP_001001490.11 
     1200195855 
    chicken
    (Gallus gallus)
    Aves OXGR11 oxoglutarate (alpha-ketoglutarate) receptor 1 65.08(n)
    63.1(a)
      428023  XM_425594.2  XP_425594.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    Uncharacterized protein
    52(a)
    50(a)
    1 ↔ many
    1 ↔ many
    3(85844778-85846982)
    3(85870659-85873004)
    zebrafish
    (Danio rerio)
    Actinopterygii oxgr1a.11 oxoglutarate (alpha-ketoglutarate) receptor 1a, tandem more 54.63(n)
    46.15(a)
      678638  NM_001040383.1  NP_001035473.1 


    ENSEMBL Gene Tree for OXGR1 (if available)
    TreeFam Gene Tree for OXGR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for OXGR1 gene
    P2RY42  GPR172  P2RY12  P2RY62  GPR1742  LPAR62  LPAR52  CYSLTR12  
    GPR1832  LPAR42  CYSLTR22  P2RY22  SUCNR12  P2RY102  PTAFR2  
    Selected SIMAP similar genes for OXGR1 using alignment to 3 protein entries:     OXGR1_HUMAN (see all proteins) (see all similar genes):
    P2RY1    CYSLTR2    KPG_011    P2RY2    P2RY4    SUCNR1
    F2RL2    GPR17    LPAR4    CCR3    CXCR2    IL8RB
    LPAR6    CCR7    P2RY8    CCR9    CYSLTR1    CXCR4

    OXGR1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for OXGR1 (see all 255)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881568991,2
    --97638466(+) CTAAAC/TCCAGT 1 -- ut310--------
    rs1411107691,2
    --97638485(+) CTCAAA/GGTTAA 1 -- ut310--------
    rs173012221,2
    C,F,H--97638626(+) AGTGAA/GAAGAT 1 -- ut319Minor allele frequency- G:0.01NA NS 816
    rs1927380811,2
    --97638645(+) TCCTAA/TCTTGG 1 -- ut310--------
    rs1842855451,2
    --97638811(+) TCTTAC/TATCTC 1 -- ut310--------
    rs1174096291,2
    F--97638901(+) ACAGTA/GTTTAC 1 -- ut311Minor allele frequency- G:0.01NA 120
    rs1891862121,2
    C--97638958(+) GTAAAG/TTATCA 1 -- ut310--------
    rs1454527441,2
    C--97638962(+) AGTATC/TAGCAA 1 -- ut310--------
    rs1457930601,2
    C,F--97639000(+) ATATTT/ACAAGG 2 /* /C --2Minor allele frequency- A:0.00NA EU 5065
    rs95844561,2
    C,F,A,H--97639021(+) TAACTA/GATTTT 2 I syn118Minor allele frequency- G:0.07NS EA NA WA CSA EU 7557

    HapMap Linkage Disequilibrium report for OXGR1 (97637973 - 97646984 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for OXGR1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832693CNV Loss17160897
    nsv7246OTHER Inversion18451855

    Human Gene Mutation Database (HGMD): OXGR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OXGR1
    DNA2.0 Custom Variant and Variant Library Synthesis for OXGR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606922    OMIM disorders: --

    1 disease for OXGR1:    About MalaCards
    hepatocellular carcinoma


    OXGR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OXGR1
    Human Genome Epidemiology (HuGE) Navigator: OXGR1 (1 document)

    Export disorders for OXGR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for OXGR1 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with OXGR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GPR99, a new G protein-coupled receptor with homology to a new subgroup of nucleotide receptors. (PubMed id 12098360)1, 2, 3, 9 Wittenberger T.... Hampe W. (BMC Genomics 2002)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Citric acid cycle intermediates as ligands for orphan G-protein- coupled receptors. (PubMed id 15141213)1, 3 He W.... Ling L. (Nature 2004)
    4. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (Nature 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification of G protein-coupled receptor genes from the human genome sequence. (PubMed id 12044878)1, 2 Takeda S.... Mitaku S. (FEBS Lett. 2002)
    7. Discovery and mapping of ten novel G protein-coupled receptor genes. (PubMed id 11574155)1, 2 Lee D.K.... O'Dowd B.F. (Gene 2001)
    8. Aberrant DNA methylation profile and frequent methylation of KLK10 and OXGR1 genes in hepatocellular carcinoma. (PubMed id 19760608)1, 9 Lu C.Y....Chang Y.S. (amp 2009)
    9. Identification and characterization of a cell-surface receptor, P2Y15, for AMP and adenosine. (PubMed id 15001573)1 Inbe H....Encinas J.A. (J. Biol. Chem. 2004)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 27199 HGNC: 4531 AceView: OXGR1 Ensembl:ENSG00000165621 euGenes: HUgn27199
    ECgene: OXGR1 H-InvDB: OXGR1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for OXGR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for OXGR1 gene:
    Search GeneIP for patents involving OXGR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for OXGR1 (OXGR1/GPR80/P2Y15)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for OXGR1   OriGene RNAi products in human, mouse, rat for OXGR1  
     OriGene qPCR primer pairs and template standards for OXGR1   OriGene Protein Over-expression Lysate for OXGR1  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for OXGR1  
     OriGene qSTAR qPCR primer pairs in human, mouse for OXGR1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for OXGR1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OXGR1   OriGene Custom Protein Services for OXGR1  

     
     
     Block miRNA regulation of human, mouse, rat OXGR1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OXGR1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OXGR1 Predesigned siRNA for gene silencing in human, mouse, rat OXGR1
     QuantiFast Probe-based Assays in human, mouse, rat OXGR1 QuantiTect SYBR Green Assays in human, mouse, rat OXGR1
     PCR Arrays including human, mouse, rat OXGR1 Search Chromatin IP Primers for OXGR1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OXGR1  Search GeneGlobe Interaction Network for OXGR1
     Regulatory tfbs in OXGR1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for OXGR1 GenScript cDNA clones with any tag delivered in your preferred vector for OXGR1
     GenScript Custom Assay Services for OXGR1 GenScript Custom overexpressing Cell Line Services for OXGR1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for OXGR1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     OXGR1 antibodies
     OXGR1 proteins
     OXGR1 lysates
     Antibodies for OXGR1
     See all of Abcam's Antibodies, Kits and Proteins for OXGR1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for OXGR1
     Antibodies for OXGR1
     ELISAs for OXGR1
     CLIAs for OXGR1



     Browse ESI BIO Cell Lines and PureStem Progenitors for OXGR1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OXGR1
     SwitchGear 3'UTR luciferase reporter plasmids for OXGR1
     SwitchGear Promoter luciferase reporter plasmids for OXGR1
     ThermoFisher Antibodies for OXGR1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OXGR1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OXGR1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OXGR1
     LSBio Antibodies in human, mouse, rat for OXGR1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OXGR1 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4