Aliases for OXER1 Gene
External Ids for OXER1 Gene
Previous GeneCards Identifiers for OXER1 Gene
GeneCards Summary for OXER1 Gene
OXER1 (Oxoeicosanoid (OXE) Receptor 1) is a Protein Coding gene. Diseases associated with OXER1 include diabetes insipidus, nephrogenic and retinitis pigmentosa. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding. An important paralog of this gene is HCAR3.
UniProtKB/Swiss-Prot for OXER1 Gene
Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.
Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They act on peroxisome-proliferating receptors (PPARs) as well as the G-protein-coupled leukotriene receptors, and are important in inflammatory signaling pathways. Leukotriene and related receptors are high affinity stereoselective receptors that have a wide biological distribution. The oxoeicosanoid receptor (OXE) is expressed in high concentrations on eosinophils, neutrophils and monocytes and is involved in chemotaxis and intracellular calcium mobilization.