Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OXER1 Gene

Aliases for OXER1 Gene

  • Oxoeicosanoid (OXE) Receptor 1 2 3 5
  • 5-Oxo-ETE Acid G-Protein-Coupled Receptor 1 2 3
  • 5-Oxo-ETE G-Protein Coupled Receptor 3 4
  • G-Protein Coupled Receptor TG1019 3 4
  • G-Protein Coupled Receptor R527 3 4
  • G-Protein Coupled Receptor 170 3 4
  • GPR170 3 4
  • TG1019 3 4
  • GPCR 3

External Ids for OXER1 Gene

Previous GeneCards Identifiers for OXER1 Gene

  • GC02M042930
  • GC02M042901
  • GC02M042843
  • GC02M042989

Summaries for OXER1 Gene

GeneCards Summary for OXER1 Gene

OXER1 (Oxoeicosanoid (OXE) Receptor 1) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding. An important paralog of this gene is HCAR3.

UniProtKB/Swiss-Prot for OXER1 Gene

  • Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.

Tocris Summary for OXER1 Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They are important in inflammatory signaling pathways.

Gene Wiki entry for OXER1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXER1 Gene

Genomics for OXER1 Gene

Regulatory Elements for OXER1 Gene

Enhancers for OXER1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around OXER1 on UCSC Golden Path with GeneCards custom track

Promoters for OXER1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OXER1 on UCSC Golden Path with GeneCards custom track

Genomic Location for OXER1 Gene

Chromosome:
2
Start:
42,762,481 bp from pter
End:
42,764,261 bp from pter
Size:
1,781 bases
Orientation:
Minus strand

Genomic View for OXER1 Gene

Genes around OXER1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OXER1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OXER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXER1 Gene

Proteins for OXER1 Gene

  • Protein details for OXER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDS5-OXER1_HUMAN
    Recommended name:
    Oxoeicosanoid receptor 1
    Protein Accession:
    Q8TDS5
    Secondary Accessions:
    • Q86WP7
    • Q8NGW4

    Protein attributes for OXER1 Gene

    Size:
    423 amino acids
    Molecular mass:
    45811 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO17739.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05878.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OXER1 Gene

Proteomics data for OXER1 Gene at MOPED

Post-translational modifications for OXER1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OXER1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OXER1 Gene

Domains & Families for OXER1 Gene

Gene Families for OXER1 Gene

Protein Domains for OXER1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OXER1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDS5

UniProtKB/Swiss-Prot:

OXER1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OXER1: view

Function for OXER1 Gene

Molecular function for OXER1 Gene

UniProtKB/Swiss-Prot Function:
Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.

Gene Ontology (GO) - Molecular Function for OXER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050646 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding NAS 12065583
GO:0050648 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding NAS 12065583
genes like me logo Genes that share ontologies with OXER1: view
genes like me logo Genes that share phenotypes with OXER1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OXER1 Gene

Localization for OXER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXER1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OXER1 Gene COMPARTMENTS Subcellular localization image for OXER1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OXER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OXER1: view

Pathways & Interactions for OXER1 Gene

genes like me logo Genes that share pathways with OXER1: view

Interacting Proteins for OXER1 Gene

Gene Ontology (GO) - Biological Process for OXER1 Gene

None

No data available for SIGNOR curated interactions for OXER1 Gene

Drugs & Compounds for OXER1 Gene

(17) Drugs for OXER1 Gene - From: DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cinalukast Approved Pharma Potent, selective CysLT1 (LTD4) antagonist; orally active 0
arachidonic acid Experimental Nutra Activator 27
[<sup>3</sup>H]5-oxo-ETE Pharma Agonist 0
5-(6-chloro-2-hexyl-1H-indol-1-yl)-5-oxo-valeric acid Pharma Antagonist 0
5-oxo-12-HETE Pharma Antagonist 0

(8) Additional Compounds for OXER1 Gene - From: Tocris and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fpl 55712
40785-97-5
Leukotriene B4
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
  • (6z,8e,10e,14z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid
  • 5,12-DiHETE
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoate
  • 5,12-Dihydroxy-6,10-trans -8,14-cis -eicosatetraenoic acid
71160-24-2
LY 255283
117690-79-6
SR 2640 hydrochloride
146662-42-2

(5) Tocris Compounds for OXER1 Gene

Compound Action Cas Number
Cinalukast Potent, selective CysLT1 (LTD4) antagonist; orally active 128312-51-6
FPL 55712 Leukotriene receptor antagonist 40785-97-5
Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor 71160-24-2
LY 255283 Selective, competitive BLT2 receptor antagonist 117690-79-6
SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist 146662-42-2
genes like me logo Genes that share compounds with OXER1: view

Transcripts for OXER1 Gene

mRNA/cDNA for OXER1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OXER1 Gene

Oxoeicosanoid (OXE) receptor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OXER1 Gene

No ASD Table

Relevant External Links for OXER1 Gene

GeneLoc Exon Structure for
OXER1
ECgene alternative splicing isoforms for
OXER1

Expression for OXER1 Gene

mRNA expression in normal human tissues for OXER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OXER1 Gene

This gene is overexpressed in Whole Blood (x10.2) and Liver (x9.5).

Protein differential expression in normal tissues from HIPED for OXER1 Gene

This gene is overexpressed in Heart (58.2) and Rectum (10.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OXER1 Gene



SOURCE GeneReport for Unigene cluster for OXER1 Gene Hs.168439

mRNA Expression by UniProt/SwissProt for OXER1 Gene

Q8TDS5-OXER1_HUMAN
Tissue specificity: Expressed in various tissues except brain. Expression is more intense in liver, kidney, peripheral leukocyte, lung, and spleen than in other tissues. Highly expressed in eosinophils, neutrophils, and lung macrophages.
genes like me logo Genes that share expression patterns with OXER1: view

Protein tissue co-expression partners for OXER1 Gene

- Elite partner

Primer Products

Orthologs for OXER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OXER1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OXER1 35
  • 81.62 (n)
  • 74.78 (a)
OXER1 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OXER1 35
  • 82.4 (n)
  • 76.23 (a)
OXER1 36
  • 71 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia OXER1 35
  • 99.45 (n)
  • 99.53 (a)
OXER1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OXER1 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hcar1-3 36
  • 38 (a)
OneToMany
hcar1-4 36
  • 31 (a)
OneToMany
Species with no ortholog for OXER1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OXER1 Gene

ENSEMBL:
Gene Tree for OXER1 (if available)
TreeFam:
Gene Tree for OXER1 (if available)

Paralogs for OXER1 Gene

Paralogs for OXER1 Gene

(4) SIMAP similar genes for OXER1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OXER1: view

Variants for OXER1 Gene

Sequence variations from dbSNP and Humsavar for OXER1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_023940 -
VAR_049428 -

Structural Variations from Database of Genomic Variants (DGV) for OXER1 Gene

Variant ID Type Subtype PubMed ID
nsv817795 CNV Gain 17921354
nsv519877 CNV Loss 19592680
nsv457152 CNV Loss 19166990

Variation tolerance for OXER1 Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for OXER1 Gene

Disorders for OXER1 Gene

Relevant External Links for OXER1

Genetic Association Database (GAD)
OXER1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OXER1

No disorders were found for OXER1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OXER1 Gene

Publications for OXER1 Gene

  1. Identification of a novel human eicosanoid receptor coupled to G(i/o). (PMID: 12065583) Hosoi T. … Ohnuki T. (J. Biol. Chem. 2002) 2 3 4 23 67
  2. International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor. (PMID: 15001665) Brink C. … Yokomizo T. (Pharmacol. Rev. 2004) 2 3
  3. OxeR1 regulates angiotensin II and cAMP-stimulated steroid production in human H295R adrenocortical cells. (PMID: 25657046) Dattilo M. … Cornejo Maciel F. (Mol. Cell. Endocrinol. 2015) 3
  4. A biased non-GI+i OXE-R antagonist demonstrates that GI+i protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE. (PMID: 24733850) Konya V. … Heinemann A. (J. Immunol. 2014) 3
  5. OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells. (PMID: 23643940) Sarveswaran S. … Ghosh J. (Cancer Lett. 2013) 3

Products for OXER1 Gene

Sources for OXER1 Gene

Content