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Aliases for OXER1 Gene

Aliases for OXER1 Gene

  • Oxoeicosanoid (OXE) Receptor 1 2 3
  • 5-Oxo-ETE Acid G-Protein-Coupled Receptor 1 2 3
  • 5-Oxo-ETE G-Protein Coupled Receptor 3 4
  • G-Protein Coupled Receptor TG1019 3 4
  • G-Protein Coupled Receptor R527 3 4
  • G-Protein Coupled Receptor 170 3 4
  • GPR170 3 4
  • TG1019 3 4
  • Oxoeicosanoid Receptor 1 3
  • GPCR 3

External Ids for OXER1 Gene

Previous GeneCards Identifiers for OXER1 Gene

  • GC02M042930
  • GC02M042901
  • GC02M042843
  • GC02M042989

Summaries for OXER1 Gene

GeneCards Summary for OXER1 Gene

OXER1 (Oxoeicosanoid (OXE) Receptor 1) is a Protein Coding gene. Diseases associated with OXER1 include diabetes insipidus, nephrogenic and retinitis pigmentosa. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include G-protein coupled receptor activity and 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding. An important paralog of this gene is HCAR3.

UniProtKB/Swiss-Prot for OXER1 Gene

  • Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.

Tocris Summary for OXER1 Gene

  • Leukotriene and related receptors are activated by the endogenous ligands leukotriene (LT) B4, LTC4, LTD4, LTE4 and 12-HETE. Leukotrienes are lipid mediators synthesized from arachidonic acid by lipoxygenase enzymes. They act on peroxisome-proliferating receptors (PPARs) as well as the G-protein-coupled leukotriene receptors, and are important in inflammatory signaling pathways. Leukotriene and related receptors are high affinity stereoselective receptors that have a wide biological distribution. The oxoeicosanoid receptor (OXE) is expressed in high concentrations on eosinophils, neutrophils and monocytes and is involved in chemotaxis and intracellular calcium mobilization.

Gene Wiki entry for OXER1 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXER1 Gene

Genomics for OXER1 Gene

Regulatory Elements for OXER1 Gene

Genomic Location for OXER1 Gene

Start:
42,762,481 bp from pter
End:
42,764,261 bp from pter
Size:
1,781 bases
Orientation:
Minus strand

Genomic View for OXER1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OXER1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXER1 Gene

Proteins for OXER1 Gene

  • Protein details for OXER1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TDS5-OXER1_HUMAN
    Recommended name:
    Oxoeicosanoid receptor 1
    Protein Accession:
    Q8TDS5
    Secondary Accessions:
    • Q86WP7
    • Q8NGW4

    Protein attributes for OXER1 Gene

    Size:
    423 amino acids
    Molecular mass:
    45811 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO17739.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC05878.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for OXER1 Gene

Proteomics data for OXER1 Gene at MOPED

Post-translational modifications for OXER1 Gene

  • Glycosylation at Asn44
  • Modification sites at PhosphoSitePlus

Other Protein References for OXER1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for OXER1 Gene

Domains for OXER1 Gene

Gene Families for OXER1 Gene

HGNC:
  • LTNR :GPCR / Class A : Leukotriene receptors
IUPHAR :

Protein Domains for OXER1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for OXER1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8TDS5

UniProtKB/Swiss-Prot:

OXER1_HUMAN :
  • Q8TDS5
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with OXER1: view

Function for OXER1 Gene

Molecular function for OXER1 Gene

UniProtKB/Swiss-Prot Function: Receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. Seems to be coupled to the G(i)/G(o), families of heteromeric G proteins.

Gene Ontology (GO) - Molecular Function for OXER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity NAS 12065583
GO:0050646 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding NAS 12065583
GO:0050647 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding NAS 12065583
GO:0050648 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding NAS 12065583
genes like me logo Genes that share ontologies with OXER1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OXER1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OXER1 Gene

Localization for OXER1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXER1 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OXER1 Gene COMPARTMENTS Subcellular localization image for OXER1 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for OXER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with OXER1: view

Pathways for OXER1 Gene

genes like me logo Genes that share pathways with OXER1: view

Interacting Proteins for OXER1 Gene

Gene Ontology (GO) - Biological Process for OXER1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway NAS 12065583
GO:0030817 regulation of cAMP biosynthetic process IDA 12065583
genes like me logo Genes that share ontologies with OXER1: view

Compounds for OXER1 Gene

(5) Tocris Compounds for OXER1 Gene

Compound Action Cas Number
17-ODYA LTB-omega-Hydroxylase inhibitor [34450-18-5]
Leukotriene B4 BLT1/BLT2 receptor agonist and potent chemotactic factor [71160-24-2]
LY 255283 Selective, competitive BLT2 receptor antagonist [117690-79-6]
MK 571 Potent CysLT1 (LTD4) inverse agonist. Also MRP inhibitor [115104-28-4]
SR 2640 hydrochloride Potent, selective LTD4 /LTE4 receptor antagonist [146662-42-2]

(1) HMDB Compounds for OXER1 Gene

Compound Synonyms Cas Number PubMed IDs
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1

(11) IUPHAR Ligand for OXER1 Gene

Ligand Type Action Affinity Pubmed IDs
5-oxo-ETE Agonist Full agonist 8.5
[3H]5-oxo-ETE Agonist Agonist 8.4
5-oxo-C20:3 Agonist Full agonist 8
5-oxo-ODE Agonist Full agonist 8
5-oxo-15-HETE Agonist Full agonist 7.7
5S-HPETE Agonist Full agonist 7
5-oxo-20-HETE Agonist Full agonist 6.5
5-(6-chloro-2-hexyl-1H-indol-1-yl)-5-oxo-valeric acid Antagonist Antagonist 6.4
5-oxo-12-HETE Antagonist Antagonist 6.3
Gue1654 Allosteric regulator Negative 6
5S-HETE Activator None

(9) Novoseek inferred chemical compound relationships for OXER1 Gene

Compound -log(P) Hits PubMed IDs
5-oxoete 79.1 3
arachidonic acid 28 2
bacteriorhodopsin 18.3 4
tyrosine 12.8 4
amine 1.52 2
genes like me logo Genes that share compounds with OXER1: view

Transcripts for OXER1 Gene

mRNA/cDNA for OXER1 Gene

(15) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OXER1 Gene

Oxoeicosanoid (OXE) receptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OXER1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OXER1 Gene

No ASD Table

Relevant External Links for OXER1 Gene

GeneLoc Exon Structure for
OXER1
ECgene alternative splicing isoforms for
OXER1

Expression for OXER1 Gene

mRNA expression in normal human tissues for OXER1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OXER1 Gene

This gene is overexpressed in Whole Blood (10.2) and Liver (9.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for OXER1 Gene

SOURCE GeneReport for Unigene cluster for OXER1 Gene Hs.168439

mRNA Expression by UniProt/SwissProt for OXER1 Gene

Q8TDS5-OXER1_HUMAN
Tissue specificity: Expressed in various tissues except brain. Expression is more intense in liver, kidney, peripheral leukocyte, lung, and spleen than in other tissues. Highly expressed in eosinophils, neutrophils, and lung macrophages.
genes like me logo Genes that share expressions with OXER1: view

In Situ Assay Products

Orthologs for OXER1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OXER1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OXER1 35
  • 99.45 (n)
  • 99.53 (a)
OXER1 36
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OXER1 35
  • 81.62 (n)
  • 74.78 (a)
OXER1 36
  • 64 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OXER1 35
  • 82.4 (n)
  • 76.23 (a)
OXER1 36
  • 71 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OXER1 36
  • 56 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii hcar1-3 36
  • 38 (a)
OneToMany
hcar1-4 36
  • 31 (a)
OneToMany
Species with no ortholog for OXER1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for OXER1 Gene

ENSEMBL:
Gene Tree for OXER1 (if available)
TreeFam:
Gene Tree for OXER1 (if available)

Paralogs for OXER1 Gene

Paralogs for OXER1 Gene

Selected SIMAP similar genes for OXER1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OXER1: view

Variants for OXER1 Gene

Sequence variations from dbSNP and Humsavar for OXER1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs893735 -- 42,764,883(+) ACTCC(C/T)TGCCC upstream-variant-2KB
rs965374 -- 42,766,026(+) GGAGG(G/T)TGAAG upstream-variant-2KB
rs1992286 -- 42,763,196(+) AGGGA(G/T)CGGCA reference, synonymous-codon
rs2278582 -- 42,762,304(+) ACCCA(A/G)GAAAG downstream-variant-500B
rs2278583 -- 42,762,452(+) ACTGA(C/T)AGTCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for OXER1 Gene

Variant ID Type Subtype PubMed ID
nsv817795 CNV Gain 17921354
nsv519877 CNV Loss 19592680
nsv457152 CNV Loss 19166990

Relevant External Links for OXER1 Gene

HapMap Linkage Disequilibrium report
OXER1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXER1 Gene

Disorders for OXER1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for OXER1 Gene including...

Search for OXER1 Gene in MalaCards »

(5) Novoseek inferred disease relationships for OXER1 Gene

Disease -log(P) Hits PubMed IDs
diabetes insipidus nephrogenic 35.1 1
retinitis pigmentosa 9.29 1
tumors 1.55 2
inflammation 0 1
cancer 0 1

Relevant External Links for OXER1

Genetic Association Database (GAD)
OXER1
genes like me logo Genes that share disorders with OXER1: view

No data available for UniProtKB/Swiss-Prot for OXER1 Gene

Publications for OXER1 Gene

  1. Identification of a novel human eicosanoid receptor coupled to G(i/o). (PMID: 12065583) Hosoi T. … Ohnuki T. (J. Biol. Chem. 2002) 2 3 4 23
  2. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4
  3. Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z- eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils. (PMID: 12606753) Jones C.E. … Finan P. (Mol. Pharmacol. 2003) 3 4
  4. International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor. (PMID: 15001665) Brink C. … Yokomizo T. (Pharmacol. Rev. 2004) 2 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for OXER1 Gene

Sources for OXER1 Gene

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