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Aliases for OXCT2 Gene

Aliases for OXCT2 Gene

  • 3-Oxoacid CoA-Transferase 2 2 3 5
  • Testis-Specific Succinyl-CoA:3-Oxoacid CoA-Transferase 3 4
  • 3-Oxoacid CoA-Transferase 2A 3 4
  • EC 2.8.3.5 4 63
  • Succinyl-CoA:3-Ketoacid-Coenzyme A Transferase 2, Mitochondrial 3
  • Testis-Specific Succinyl CoA:3-Oxoacid CoA-Transferase 3
  • 3-Oxoacid-CoA Transferase 2A 3
  • 3-Oxoacid CoA Transferase 2 3
  • EC 2.8.3 63
  • FKSG25 3
  • SCOT-T 4
  • SCOTT 3

External Ids for OXCT2 Gene

Previous GeneCards Identifiers for OXCT2 Gene

  • GC01P039898
  • GC01M039238
  • GC01M039698
  • GC01M039648
  • GC01M039904
  • GC01M040007
  • GC01M040235
  • GC01M038353

Summaries for OXCT2 Gene

Entrez Gene Summary for OXCT2 Gene

  • OXCT2 is a testis-specific succinyl-CoA:3-oxoacid CoA transferase (EC 2.8.3.5), which catalyzes the reversible transfer of CoA from succinyl-CoA to acetoacetate in the first step of ketone body utilization. See also OXCT1 (MIM 601424).[supplied by OMIM, Mar 2008]

GeneCards Summary for OXCT2 Gene

OXCT2 (3-Oxoacid CoA-Transferase 2) is a Protein Coding gene. Among its related pathways are Valine, leucine and isoleucine degradation and Butanoate metabolism. GO annotations related to this gene include 3-oxoacid CoA-transferase activity and CoA-transferase activity. An important paralog of this gene is OXCT1.

UniProtKB/Swiss-Prot for OXCT2 Gene

  • Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXCT2 Gene

Genomics for OXCT2 Gene

Regulatory Elements for OXCT2 Gene

Promoters for OXCT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around OXCT2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OXCT2 Gene

Chromosome:
1
Start:
39,769,523 bp from pter
End:
39,771,348 bp from pter
Size:
1,826 bases
Orientation:
Minus strand

Genomic View for OXCT2 Gene

Genes around OXCT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OXCT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OXCT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXCT2 Gene

Proteins for OXCT2 Gene

  • Protein details for OXCT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYC2-SCOT2_HUMAN
    Recommended name:
    Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial
    Protein Accession:
    Q9BYC2
    Secondary Accessions:
    • B2RBB4
    • Q5QPK4
    • Q8NHR1
    • Q9H1I4

    Protein attributes for OXCT2 Gene

    Size:
    517 amino acids
    Molecular mass:
    56140 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for OXCT2 Gene

Proteomics data for OXCT2 Gene at MOPED

Post-translational modifications for OXCT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OXCT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for OXCT2 Gene

Suggested Antigen Peptide Sequences for OXCT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYC2

UniProtKB/Swiss-Prot:

SCOT2_HUMAN :
  • Belongs to the 3-oxoacid CoA-transferase family.
Family:
  • Belongs to the 3-oxoacid CoA-transferase family.
genes like me logo Genes that share domains with OXCT2: view

No data available for Gene Families for OXCT2 Gene

Function for OXCT2 Gene

Molecular function for OXCT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.
UniProtKB/Swiss-Prot Function:
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).

Enzyme Numbers (IUBMB) for OXCT2 Gene

genes like me logo Genes that share phenotypes with OXCT2: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OXCT2 Gene

Localization for OXCT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXCT2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OXCT2 Gene COMPARTMENTS Subcellular localization image for OXCT2 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for OXCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031514 motile cilium IDA 11756565
genes like me logo Genes that share ontologies with OXCT2: view

Pathways & Interactions for OXCT2 Gene

genes like me logo Genes that share pathways with OXCT2: view

UniProtKB/Swiss-Prot Q9BYC2-SCOT2_HUMAN

  • Pathway: Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.

Interacting Proteins for OXCT2 Gene

Gene Ontology (GO) - Biological Process for OXCT2 Gene

None

No data available for SIGNOR curated interactions for OXCT2 Gene

Drugs & Compounds for OXCT2 Gene

(6) Drugs for OXCT2 Gene - From: HMDB, ApexBio, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Full agonist, Agonist, Target 0
Acetoacetic acid Experimental Pharma 0
Acetoacetyl-CoA Experimental Pharma 0
Succinyl-CoA Experimental Pharma 0
LB42708 Pharma Selective FTase inhibitor 0

(2) ApexBio Compounds for OXCT2 Gene

Compound Action Cas Number
LB42708 Selective FTase inhibitor 226929-39-1
Lonafarnib Ftase inhibitor,potent and selective 193275-84-2
genes like me logo Genes that share compounds with OXCT2: view

Transcripts for OXCT2 Gene

mRNA/cDNA for OXCT2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OXCT2 Gene

3-oxoacid CoA transferase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OXCT2 Gene

No ASD Table

Relevant External Links for OXCT2 Gene

GeneLoc Exon Structure for
OXCT2
ECgene alternative splicing isoforms for
OXCT2

Expression for OXCT2 Gene

mRNA expression in normal human tissues for OXCT2 Gene

mRNA differential expression in normal tissues according to GTEx for OXCT2 Gene

This gene is overexpressed in Testis (x29.2).

Protein differential expression in normal tissues from HIPED for OXCT2 Gene

This gene is overexpressed in Brain (47.2) and Heart (21.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OXCT2 Gene



SOURCE GeneReport for Unigene cluster for OXCT2 Gene Hs.472491

mRNA Expression by UniProt/SwissProt for OXCT2 Gene

Q9BYC2-SCOT2_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with OXCT2: view

Protein tissue co-expression partners for OXCT2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for OXCT2 Gene

Orthologs for OXCT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OXCT2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC100297708 35
  • 81.88 (n)
  • 80.19 (a)
chimpanzee
(Pan troglodytes)
Mammalia OXCT2 35
  • 99.55 (n)
  • 99.03 (a)
rat
(Rattus norvegicus)
Mammalia LOC100365119 35
  • 77.28 (n)
  • 74.37 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 50 (a)
OneToMany
-- 36
  • 50 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Oxct2a 36
  • 75 (a)
OneToMany
Oxct2b 36
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
-- 36
  • 42 (a)
OneToMany
chicken
(Gallus gallus)
Aves OXCT1 36
  • 71 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 68 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii oxct1a 36
  • 67 (a)
ManyToMany
oxct1b 36
  • 64 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1140 37
  • 59 (a)
CG1140 36
  • 56 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C05C10.3 37
  • 57 (a)
C05C10.3 36
  • 54 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1452 36
  • 61 (a)
OneToMany
Species with no ortholog for OXCT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for OXCT2 Gene

ENSEMBL:
Gene Tree for OXCT2 (if available)
TreeFam:
Gene Tree for OXCT2 (if available)

Paralogs for OXCT2 Gene

Paralogs for OXCT2 Gene

(3) SIMAP similar genes for OXCT2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OXCT2 Gene

genes like me logo Genes that share paralogs with OXCT2: view

Variants for OXCT2 Gene

Sequence variations from dbSNP and Humsavar for OXCT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_059134 -
VAR_059135 -

Structural Variations from Database of Genomic Variants (DGV) for OXCT2 Gene

Variant ID Type Subtype PubMed ID
nsv7177 OTHER Inversion 18451855
dgv15n27 CNV Gain 19166990
dgv215n71 CNV Loss 21882294
dgv49e1 CNV Complex 17122850

Variation tolerance for OXCT2 Gene

Gene Damage Index Score: 1.51; 29.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OXCT2 Gene

HapMap Linkage Disequilibrium report
OXCT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXCT2 Gene

Disorders for OXCT2 Gene

Relevant External Links for OXCT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OXCT2

No disorders were found for OXCT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OXCT2 Gene

Publications for OXCT2 Gene

  1. Cloning and characterization of a human orthologue of testis-specific succinyl CoA:3-oxo acid CoA transferase (Scot-t) cDNA. (PMID: 11756565) Tanaka H. … Nishimune Y. (Mol. Hum. Reprod. 2002) 2 3 4 23 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for OXCT2 Gene

Sources for OXCT2 Gene

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