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Aliases for OXCT2 Gene

Aliases for OXCT2 Gene

  • 3-Oxoacid CoA-Transferase 2 2 3 5
  • 3-Oxoacid CoA-Transferase 2A 3 4
  • EC 2.8.3.5 4 61
  • Succinyl-CoA:3-Ketoacid Coenzyme A Transferase 2, Mitochondrial 3
  • Testis-Specific Succinyl CoA:3-Oxoacid CoA-Transferase 3
  • Testis-Specific Succinyl-CoA:3-Oxoacid CoA-Transferase 4
  • EC 2.8.3 61
  • FKSG25 3
  • SCOT-T 4
  • SCOTT 3

External Ids for OXCT2 Gene

Previous GeneCards Identifiers for OXCT2 Gene

  • GC01P039898
  • GC01M039238
  • GC01M039698
  • GC01M039648
  • GC01M039904
  • GC01M040007
  • GC01M040235
  • GC01M038353

Summaries for OXCT2 Gene

Entrez Gene Summary for OXCT2 Gene

  • The protein encoded by this gene catalyzes the transfer of a CoA group from succinate to acetoacetate and is an important enzyme in ketone body catabolism. The encoded protein localizes to the mitochondrion. This gene is intronless, and a pseudogene of this gene is located elsewhere on chromosome 1. [provided by RefSeq, Aug 2016]

GeneCards Summary for OXCT2 Gene

OXCT2 (3-Oxoacid CoA-Transferase 2) is a Protein Coding gene. Among its related pathways are Butanoate metabolism and Valine, leucine and isoleucine degradation. GO annotations related to this gene include 3-oxoacid CoA-transferase activity and CoA-transferase activity. An important paralog of this gene is OXCT1.

UniProtKB/Swiss-Prot for OXCT2 Gene

  • Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXCT2 Gene

Genomics for OXCT2 Gene

Regulatory Elements for OXCT2 Gene

Enhancers for OXCT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F039788 0.2 ENCODE 16.9 -17.9 -17911 1.1 ATF1 CREB3L1 GLIS2 ELK1 SP3 NFYC REST ZNF623 SMARCA4 GLIS1 OXCT2 BMP8B PPIE LOC101929536 ENSG00000229213
GH01F039779 0.4 FANTOM5 15.2 -8.5 -8546 0.2 FOSL1 ZNF121 ZBTB48 ZBTB17 TMCO2 OXCT2 PPIE HEYL LOC105378666
GH01F039775 0.8 Ensembl 14.6 -4.8 -4844 1.2 PKNOX1 ARNT NFRKB BMI1 ZBTB40 POLR2A EED ETV6 FOS CREM PPIE OXCT2 OXCT2P1 BMP8B LOC105378666
GH01F039738 0.2 ENCODE 11.8 +32.3 32336 1.8 ATF1 SIN3A ZNF2 YY1 GLIS2 ELK1 SP3 YY2 ZHX2 ZNF518A PPIE BMP8B OXCT2 ENSG00000202222 TRIT1 PIR58872 RNU7-121P
GH01F039803 0.4 Ensembl 11.6 -32.7 -32653 0.4 OXCT2 MYCL TRIT1 ENSG00000202222 CAP1 LOC105378665 GC01P039799
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around OXCT2 on UCSC Golden Path with GeneCards custom track

Promoters for OXCT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001744007 48 201 SCRT2
ENSR00001744006 648 601 IKZF1

Genomic Location for OXCT2 Gene

Chromosome:
1
Start:
39,769,523 bp from pter
End:
39,771,348 bp from pter
Size:
1,826 bases
Orientation:
Minus strand

Genomic View for OXCT2 Gene

Genes around OXCT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OXCT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OXCT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXCT2 Gene

Proteins for OXCT2 Gene

  • Protein details for OXCT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYC2-SCOT2_HUMAN
    Recommended name:
    Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial
    Protein Accession:
    Q9BYC2
    Secondary Accessions:
    • B2RBB4
    • Q5QPK4
    • Q8NHR1
    • Q9H1I4

    Protein attributes for OXCT2 Gene

    Size:
    517 amino acids
    Molecular mass:
    56140 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for OXCT2 Gene

Post-translational modifications for OXCT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OXCT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for OXCT2 Gene

Suggested Antigen Peptide Sequences for OXCT2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BYC2

UniProtKB/Swiss-Prot:

SCOT2_HUMAN :
  • Belongs to the 3-oxoacid CoA-transferase family.
Family:
  • Belongs to the 3-oxoacid CoA-transferase family.
genes like me logo Genes that share domains with OXCT2: view

No data available for Gene Families for OXCT2 Gene

Function for OXCT2 Gene

Molecular function for OXCT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.
UniProtKB/Swiss-Prot Function:
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).

Enzyme Numbers (IUBMB) for OXCT2 Gene

Gene Ontology (GO) - Molecular Function for OXCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008260 3-oxoacid CoA-transferase activity IEA --
GO:0008410 CoA-transferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with OXCT2: view
genes like me logo Genes that share phenotypes with OXCT2: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OXCT2 Gene

Localization for OXCT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXCT2 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OXCT2 Gene COMPARTMENTS Subcellular localization image for OXCT2 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for OXCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 11756565
GO:0031514 motile cilium IDA 11756565
genes like me logo Genes that share ontologies with OXCT2: view

Pathways & Interactions for OXCT2 Gene

genes like me logo Genes that share pathways with OXCT2: view

UniProtKB/Swiss-Prot Q9BYC2-SCOT2_HUMAN

  • Pathway: Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.

Gene Ontology (GO) - Biological Process for OXCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0046952 ketone body catabolic process IEA --
genes like me logo Genes that share ontologies with OXCT2: view

No data available for SIGNOR curated interactions for OXCT2 Gene

Drugs & Compounds for OXCT2 Gene

(6) Drugs for OXCT2 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Full agonist, Agonist, Target 0
Acetoacetic acid Experimental Pharma 0
Acetoacetyl-CoA Experimental Pharma 0
Succinyl-CoA Experimental Pharma 0
LB42708 Pharma Selective FTase inhibitor, Selective farnesyltransferase (FTase) inhibitor 0

(2) ApexBio Compounds for OXCT2 Gene

Compound Action Cas Number
LB42708 Selective FTase inhibitor 226929-39-1
Lonafarnib Ftase inhibitor,potent and selective 193275-84-2
genes like me logo Genes that share compounds with OXCT2: view

Transcripts for OXCT2 Gene

mRNA/cDNA for OXCT2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OXCT2 Gene

3-oxoacid CoA transferase 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OXCT2 Gene

No ASD Table

Relevant External Links for OXCT2 Gene

GeneLoc Exon Structure for
OXCT2
ECgene alternative splicing isoforms for
OXCT2

Expression for OXCT2 Gene

mRNA expression in normal human tissues for OXCT2 Gene

mRNA differential expression in normal tissues according to GTEx for OXCT2 Gene

This gene is overexpressed in Testis (x29.2).

Protein differential expression in normal tissues from HIPED for OXCT2 Gene

This gene is overexpressed in Brain (47.2) and Heart (21.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OXCT2 Gene



Protein tissue co-expression partners for OXCT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OXCT2 Gene:

OXCT2

SOURCE GeneReport for Unigene cluster for OXCT2 Gene:

Hs.472491

mRNA Expression by UniProt/SwissProt for OXCT2 Gene:

Q9BYC2-SCOT2_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with OXCT2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for OXCT2 Gene

Orthologs for OXCT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OXCT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OXCT2 34
  • 99.55 (n)
cow
(Bos Taurus)
Mammalia LOC100297708 34
  • 81.88 (n)
rat
(Rattus norvegicus)
Mammalia LOC100365119 34
  • 77.28 (n)
mouse
(Mus musculus)
Mammalia Oxct2a 35
  • 75 (a)
OneToMany
Oxct2b 35
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 62 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 35
  • 50 (a)
OneToMany
-- 35
  • 50 (a)
OneToMany
chicken
(Gallus gallus)
Aves OXCT1 35
  • 71 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 68 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii oxct1a 35
  • 67 (a)
ManyToMany
oxct1b 35
  • 64 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG1140 36 35
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea C05C10.3 36 35
  • 57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1452 35
  • 61 (a)
OneToMany
Species where no ortholog for OXCT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for OXCT2 Gene

ENSEMBL:
Gene Tree for OXCT2 (if available)
TreeFam:
Gene Tree for OXCT2 (if available)

Paralogs for OXCT2 Gene

Paralogs for OXCT2 Gene

(3) SIMAP similar genes for OXCT2 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for OXCT2 Gene

genes like me logo Genes that share paralogs with OXCT2: view

Variants for OXCT2 Gene

Sequence variations from dbSNP and Humsavar for OXCT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1050917 -- 39,769,817(-) GAAAG(A/G)GCTGA intron-variant, reference, missense
rs1050918 -- 39,769,659(-) GGCGG(A/G)TGCCA intron-variant, utr-variant-3-prime
rs111331631 -- 39,770,407(+) AGGAT(A/C)GTTAA intron-variant, reference, synonymous-codon
rs111358708 -- 39,769,487(+) CCTGC(C/G)CCTTG intron-variant, downstream-variant-500B
rs112946539 -- 39,770,456(+) CGCGA(C/T)CTACA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for OXCT2 Gene

Variant ID Type Subtype PubMed ID
dgv152n100 CNV gain 25217958
dgv153n100 CNV gain 25217958
dgv15n27 CNV gain 19166990
esv2758933 CNV loss 17122850
nsv1116447 OTHER inversion 24896259
nsv546063 CNV gain 21841781
nsv7177 OTHER inversion 18451855
nsv945895 CNV duplication 23825009
nsv950654 CNV deletion 24416366

Variation tolerance for OXCT2 Gene

Gene Damage Index Score: 1.51; 29.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OXCT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OXCT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXCT2 Gene

Disorders for OXCT2 Gene

Relevant External Links for OXCT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OXCT2

No disorders were found for OXCT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OXCT2 Gene

Publications for OXCT2 Gene

  1. Cloning and characterization of a human orthologue of testis-specific succinyl CoA:3-oxo acid CoA transferase (Scot-t) cDNA. (PMID: 11756565) Tanaka H. … Nishimune Y. (Mol. Hum. Reprod. 2002) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A. … Ohara O. (DNA Res. 2000) 2 3 64
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for OXCT2 Gene

Sources for OXCT2 Gene

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