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Aliases for OXCT2 Gene

Aliases for OXCT2 Gene

  • 3-Oxoacid CoA-Transferase 2 2 3 5
  • 3-Oxoacid CoA-Transferase 2A 3 4
  • EC 4 58
  • Succinyl-CoA:3-Ketoacid Coenzyme A Transferase 2, Mitochondrial 3
  • Testis-Specific Succinyl CoA:3-Oxoacid CoA-Transferase 3
  • Testis-Specific Succinyl-CoA:3-Oxoacid CoA-Transferase 4
  • EC 2.8.3 58
  • FKSG25 3
  • SCOT-T 4
  • SCOTT 3

External Ids for OXCT2 Gene

Previous GeneCards Identifiers for OXCT2 Gene

  • GC01P039898
  • GC01M039238
  • GC01M039698
  • GC01M039648
  • GC01M039904
  • GC01M040007
  • GC01M040235
  • GC01M038353

Summaries for OXCT2 Gene

Entrez Gene Summary for OXCT2 Gene

  • The protein encoded by this gene catalyzes the transfer of a CoA group from succinate to acetoacetate and is an important enzyme in ketone body catabolism. The encoded protein localizes to the mitochondrion. This gene is intronless, and a pseudogene of this gene is located elsewhere on chromosome 1. [provided by RefSeq, Aug 2016]

GeneCards Summary for OXCT2 Gene

OXCT2 (3-Oxoacid CoA-Transferase 2) is a Protein Coding gene. Among its related pathways are Butanoate metabolism and Valine, leucine and isoleucine degradation. GO annotations related to this gene include 3-oxoacid CoA-transferase activity and CoA-transferase activity. An important paralog of this gene is OXCT1.

UniProtKB/Swiss-Prot for OXCT2 Gene

  • Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).

Additional gene information for OXCT2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OXCT2 Gene

Genomics for OXCT2 Gene

Regulatory Elements for OXCT2 Gene

Enhancers for OXCT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H039788 1 ENCODE 16.9 -17.9 -17911 1.1 ATF1 SIN3A GLIS2 ELK1 SP3 NFYC REST ZNF623 ZNF592 SMARCA4 PPIE OXCT2 PPIEL EXO5 BMP8B RLF ENSG00000182109 LOC101929536 ENSG00000229213
GH01H039816 1.9 FANTOM5 Ensembl ENCODE dbSUPER 8.1 -45.9 -45922 2 HDGF PKNOX1 ATF1 ARID4B ZNF2 ZNF121 ZNF766 ZNF143 FOS ATF7 TRIT1 OXCT2 PPIE MACF1 TMCO2 RLF MFSD2A PABPC4 ENSG00000284678 GC01P039816
GH01H039573 1.3 ENCODE dbSUPER 10.4 +195.9 195935 4.1 HDGF PKNOX1 ARNT ARID4B SIN3A YY1 ZNF766 ZNF207 ZNF143 REST OXCT2P1 PABPC4 PPIE OXCT2 RRAGC GC01M039568 GC01M039569 SNORA55
GH01H039508 1.3 Ensembl ENCODE dbSUPER 9.6 +261.9 261902 1.5 HDGF PKNOX1 MAX ZIC2 POLR2A EGR1 ETV6 RUNX3 IKZF2 EGR2 OXCT2P1 OXCT2 GC01P039508 PIR36307
GH01H039738 1 ENCODE 11.8 +32.3 32336 1.8 ATF1 SIN3A ZNF2 YY1 ETS1 GLIS2 ELK1 ATF7 RUNX3 SP3 PPIE BMP8B OXCT2 TRIT1 ENSG00000202222 RNU7-121P PIR58872
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OXCT2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for OXCT2 Gene

Genomic Locations for OXCT2 Gene
1,826 bases
Minus strand

Genomic View for OXCT2 Gene

Genes around OXCT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OXCT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OXCT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OXCT2 Gene

Proteins for OXCT2 Gene

  • Protein details for OXCT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B2RBB4
    • Q5QPK4
    • Q8NHR1
    • Q9H1I4

    Protein attributes for OXCT2 Gene

    517 amino acids
    Molecular mass:
    56140 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for OXCT2 Gene

Selected DME Specific Peptides for OXCT2 Gene


Post-translational modifications for OXCT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OXCT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for OXCT2 Gene

Gene Families for OXCT2 Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for OXCT2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the 3-oxoacid CoA-transferase family.
  • Belongs to the 3-oxoacid CoA-transferase family.
genes like me logo Genes that share domains with OXCT2: view

Function for OXCT2 Gene

Molecular function for OXCT2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Succinyl-CoA + a 3-oxo acid = succinate + a 3-oxoacyl-CoA.
UniProtKB/Swiss-Prot Function:
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).

Enzyme Numbers (IUBMB) for OXCT2 Gene

Phenotypes From GWAS Catalog for OXCT2 Gene

Gene Ontology (GO) - Molecular Function for OXCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008260 3-oxoacid CoA-transferase activity TAS --
GO:0008410 CoA-transferase activity IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with OXCT2: view
genes like me logo Genes that share phenotypes with OXCT2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OXCT2 Gene

Localization for OXCT2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OXCT2 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OXCT2 gene
Compartment Confidence
mitochondrion 5

Gene Ontology (GO) - Cellular Components for OXCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 11756565
GO:0005759 mitochondrial matrix TAS --
GO:0031514 motile cilium IDA 11756565
genes like me logo Genes that share ontologies with OXCT2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for OXCT2 Gene

Pathways & Interactions for OXCT2 Gene

genes like me logo Genes that share pathways with OXCT2: view

UniProtKB/Swiss-Prot Q9BYC2-SCOT2_HUMAN

  • Pathway: Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.

Gene Ontology (GO) - Biological Process for OXCT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
GO:0046952 ketone body catabolic process TAS --
genes like me logo Genes that share ontologies with OXCT2: view

No data available for SIGNOR curated interactions for OXCT2 Gene

Drugs & Compounds for OXCT2 Gene

(6) Drugs for OXCT2 Gene - From: DrugBank, ApexBio, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Succinic acid Approved Nutra Full agonist, Agonist, Target 0
Acetoacetic acid Experimental Pharma 0
Acetoacetyl-CoA Experimental Pharma 0
Succinyl-CoA Experimental Pharma 0
LB42708 Pharma Selective FTase inhibitor 0

(2) ApexBio Compounds for OXCT2 Gene

Compound Action Cas Number
LB42708 Selective FTase inhibitor 226929-39-1
Lonafarnib Ftase inhibitor,potent and selective 193275-84-2
genes like me logo Genes that share compounds with OXCT2: view

Drug Products

Transcripts for OXCT2 Gene

mRNA/cDNA for OXCT2 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(27) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OXCT2 Gene

3-oxoacid CoA transferase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for OXCT2 Gene

No ASD Table

Relevant External Links for OXCT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for OXCT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OXCT2 Gene

mRNA differential expression in normal tissues according to GTEx for OXCT2 Gene

This gene is overexpressed in Testis (x29.2).

Protein differential expression in normal tissues from HIPED for OXCT2 Gene

This gene is overexpressed in Brain (47.2) and Heart (21.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for OXCT2 Gene

Protein tissue co-expression partners for OXCT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of OXCT2 Gene:


SOURCE GeneReport for Unigene cluster for OXCT2 Gene:


mRNA Expression by UniProt/SwissProt for OXCT2 Gene:

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with OXCT2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OXCT2 Gene

Orthologs for OXCT2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OXCT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia OXCT2 33
  • 99.55 (n)
(Bos Taurus)
Mammalia LOC100297708 33
  • 81.88 (n)
(Rattus norvegicus)
Mammalia LOC100365119 33
  • 77.28 (n)
(Mus musculus)
Mammalia Oxct2a 34
  • 75 (a)
Oxct2b 34
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 62 (a)
-- 34
  • 42 (a)
(Canis familiaris)
Mammalia -- 34
  • 50 (a)
-- 34
  • 50 (a)
(Gallus gallus)
Aves OXCT1 34
  • 71 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 68 (a)
(Danio rerio)
Actinopterygii oxct1a 34
  • 67 (a)
oxct1b 34
  • 64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG1140 35 34
  • 59 (a)
(Caenorhabditis elegans)
Secernentea C05C10.3 35 34
  • 57 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1452 34
  • 61 (a)
Species where no ortholog for OXCT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for OXCT2 Gene

Gene Tree for OXCT2 (if available)
Gene Tree for OXCT2 (if available)

Paralogs for OXCT2 Gene

Paralogs for OXCT2 Gene

(3) SIMAP similar genes for OXCT2 Gene using alignment to 2 proteins: Pseudogenes for OXCT2 Gene

genes like me logo Genes that share paralogs with OXCT2: view

Variants for OXCT2 Gene

Sequence variations from dbSNP and Humsavar for OXCT2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1003550307 -- 39,771,469(+) TCCGT(C/G)TCCAG intron-variant, upstream-variant-2KB
rs1003820866 -- 39,772,666(+) CACAT(A/C)ATTCA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1004108609 -- 39,773,111(+) AAATG(C/T)TAATA intron-variant, nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs1005518194 -- 39,770,784(+) CGTGG(A/G)GGTGT intron-variant, reference, missense
rs1010964719 -- 39,772,118(+) TCAGT(C/G)AGACC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for OXCT2 Gene

Variant ID Type Subtype PubMed ID
nsv950654 CNV deletion 24416366
nsv945895 CNV duplication 23825009
nsv7177 OTHER inversion 18451855
nsv546063 CNV gain 21841781
nsv1116447 OTHER inversion 24896259
esv2758933 CNV loss 17122850
dgv15n27 CNV gain 19166990
dgv153n100 CNV gain 25217958
dgv152n100 CNV gain 25217958

Variation tolerance for OXCT2 Gene

Gene Damage Index Score: 1.51; 29.38% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OXCT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OXCT2 Gene

Disorders for OXCT2 Gene

Relevant External Links for OXCT2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OXCT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OXCT2 Gene

Publications for OXCT2 Gene

  1. Cloning and characterization of a human orthologue of testis-specific succinyl CoA: 3-oxo acid CoA transferase (Scot-t) cDNA. (PMID: 11756565) Tanaka H … Nishimune Y (Molecular human reproduction 2002) 2 3 4 22 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Characterization of long cDNA clones from human adult spleen. (PMID: 11214971) Hattori A … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 60

Products for OXCT2 Gene

Sources for OXCT2 Gene

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