Aliases for OXCT2 Gene
External Ids for OXCT2 Gene
Previous GeneCards Identifiers for OXCT2 Gene
OXCT2 is a testis-specific succinyl-CoA:3-oxoacid CoA transferase (EC 220.127.116.11), which catalyzes the reversible transfer of CoA from succinyl-CoA to acetoacetate in the first step of ketone body utilization. See also OXCT1 (MIM 601424).[supplied by OMIM, Mar 2008]
GeneCards Summary for OXCT2 Gene
OXCT2 (3-Oxoacid CoA-Transferase 2) is a Protein Coding gene. Among its related pathways are Valine, leucine and isoleucine degradation and Butanoate metabolism. GO annotations related to this gene include 3-oxoacid CoA-transferase activity and CoA-transferase activity. An important paralog of this gene is OXCT1.
UniProtKB/Swiss-Prot for OXCT2 Gene
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).