Aliases for OXCT2 Gene
External Ids for OXCT2 Gene
Previous GeneCards Identifiers for OXCT2 Gene
The protein encoded by this gene catalyzes the transfer of a CoA group from succinate to acetoacetate and is an important enzyme in ketone body catabolism. The encoded protein localizes to the mitochondrion. This gene is intronless, and a pseudogene of this gene is located elsewhere on chromosome 1. [provided by RefSeq, Aug 2016]
GeneCards Summary for OXCT2 Gene
OXCT2 (3-Oxoacid CoA-Transferase 2) is a Protein Coding gene. Among its related pathways are Valine, leucine and isoleucine degradation and Butanoate metabolism. Gene Ontology (GO) annotations related to this gene include 3-oxoacid CoA-transferase activity and CoA-transferase activity. An important paralog of this gene is OXCT1.
UniProtKB/Swiss-Prot for OXCT2 Gene
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity).