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OVOS2 Gene

pseudogene   GIFtS: 34
GCID: GC12M031267

Ovostatin 2


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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ovostatin 22
Ovostatin Homolog 22

External Ids:    Entrez Gene: 1442032   Ensembl: ENSG000001773597   UniProtKB: Q6IE363   

Export aliases for OVOS2 gene to outside databases

Previous GC identifers: GC12M031156 GC12M031157 GC12M031163 GC12M031265


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for OVOS2 Gene:
OVOS2 is a pseudogene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot: OVOS2_HUMAN, Q6IE36
Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_009714.18  NT_187587.1  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OVOS2 gene promoter:
         TBP   LHX3b/Lhx3b   Pbx1a   Brachyury   POU3F1   HNF-1A   CREB   HNF-1   LHX3a/Lhx3a   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OVOS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.21   Ensembl cytogenetic band:  12p11.21   

OVOS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OVOS2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M031267:  view genomic region     (about GC identifiers)

Start:
31,264,586 bp from pter      End:
31,359,088 bp from pter
Size:
94,503 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OVOS2_HUMAN, Q6IE36 (See protein sequence)
Recommended Name: Ovostatin homolog 2 precursor  
Size: 1432 amino acids; 161251 Da
Subunit: Homotetramer (By similarity)
Sequence caution: Sequence=CAE51409.1; Type=Erroneous gene model prediction;

Explore the universe of human proteins at neXtProt for OVOS2: NX_Q6IE36

Explore proteomics data for OVOS2 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn35, Asn59, Asn159, Asn375, Asn858
  • Modification sites at PhosphoSitePlus

  • See OVOS2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR014756 Ig_E-set
     IPR001599 Macroglobln_a2
     IPR011626 A2M_comp
     IPR002890 A2M_N
     IPR011625 A2M_N_2

    Graphical View of Domain Structure for InterPro Entry Q6IE36

    ProtoNet protein and cluster: Q6IE36

    UniProtKB/Swiss-Prot: OVOS2_HUMAN, Q6IE36
    Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family


    Find genes that share domains with OVOS2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OVOS2_HUMAN, Q6IE36
    Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
         
    Find genes that share ontologies with OVOS2           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OVOS2_HUMAN, Q6IE36: Secreted (By similarity)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    Find genes that share ontologies with OVOS2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OVOS2
    Interactions:

        Search GeneGlobe Interaction Network for OVOS2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OVOS2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for OVOS2 gene (2 alternative transcripts): 
    NM_001080502.1  NM_173498.1  

    Unigene Cluster for OVOS2:

    Ovostatin 2
    Hs.524331  [show with all ESTs]
    Unigene Representative Sequence: CR749395
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000542490(uc001rjz.3) ENST00000542925 ENST00000398963(uc010sjy.1)
    ENST00000391394 ENST00000518559 ENST00000535072(uc001rjy.3)
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    Additional mRNA sequence: 

    AL831947.1 BC029816.1 BC039117.1 BC046190.1 CR749395.1 

    14 DOTS entries:

    DT.100027310  DT.92468056  DT.101984145  DT.416416  DT.100027309  DT.40130872  DT.95114876  DT.92427039 
    DT.121149409  DT.121149415  DT.95191967  DT.121149408  DT.121149466  DT.97816159 

    Selected AceView cDNA sequences (see all 63):

    X85621 X85617 AA665477 BU732570 BN000357 AW768250 AI963894 BC039117 
    BX955676 T18947 AI004884 BU615950 BV199369 BC046190 AI914285 BV204929 
    BF059235 BF448350 BF446506 AI814637 BM564308 BC029816 AI872967 BI828289 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    OVOS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCATCTGA
    OVOS2 Expression
    About this image

    OVOS2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OVOS2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.524331
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for OVOS2 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia BC0485461 cDNA sequence BC048546 72.32(n)
    64.11(a)
      232400  NM_001001179.3  NP_001001179.2 
    chicken
    (Gallus gallus)
    Aves OVST1 ovostatin 55.39(n)
    44.39(a)
      396151  NM_205226.1  NP_990557.1 


    ENSEMBL Gene Tree for OVOS2 (if available)
    TreeFam Gene Tree for OVOS2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for OVOS2 gene
    10 SIMAP similar genes for OVOS2 using alignment to 2 protein entries:     OVOS2_HUMAN (see all proteins):
    DKFZp686C0338    OVOS1    A2M    PZP    A2ML1    C3
    C4A    C4B    C4B_2    CPAMD8

    Find genes that share paralogs with OVOS2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for OVOS2 (see all 2782)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23028541,2
    F--31134538(+) CCTTTT/CACAAA 1 -- ds5001 trp31Minor allele frequency- C:0.07EA 742
    rs2021297521,2
    C--31134538(+) CCTTTC/TACAAA 1 -- ds50010--------
    rs25433141,2
    --31134753(+) TAGAAA/CAAATG 1 -- ds50010--------
    rs1498366041,2
    --31134814(+) TTTTAC/TGGAAC 1 -- ds50010--------
    rs25433151,2
    --31134872(+) AAAAAC/TATATG 1 -- ds50010--------
    rs1458463291,2
    --31134920(+) ATGAAA/GTACAC 1 -- ds50010--------
    rs1418634421,2
    C--31134986(+) TAGTTC/TTGTTT 1 -- ds50010--------
    rs1857318931,2
    C--31135038(+) CTCTAC/TGTAGC 2 I V mis10--------
    rs1909817611,2
    --31135043(+) TGTAGC/GTGTCT 2 T S mis10--------
    rs1140609441,2
    F--31135297(+) GAAGAG/TAAAAT 1 -- int11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for OVOS2 (31264586 - 31359088 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OVOS2: --
    Human Gene Mutation Database (HGMD): OVOS2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing OVOS2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with OVOS2           About GenesLikeMe

    Genetic Association Database (GAD): OVOS2
    Human Genome Epidemiology (HuGE) Navigator: OVOS2 (1 document)

    Export disorders for OVOS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for OVOS2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OVOS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PubMed id 20808825)1, 4 Chen X....Kong X. (PLoS ONE 2010)
    2. A genomic analysis of rat proteases and protease inhibitors. (PubMed id 15060002)1, 2 Puente X.S. and Lopez-Otin C. (Genome Res. 2004)
    3. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (Nature 2006)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 144203 AceView: OVOS2 Ensembl:ENSG00000177359 euGenes: HUgn144203

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for OVOS2 gene:
    Search GeneIP for patents involving OVOS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse ESI BIO Cell Lines and PureStem Progenitors for OVOS2
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for OVOS2
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     Search ThermoFisher Antibodies for OVOS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OVOS2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OVOS2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OVOS2
     LSBio Antibodies in human, mouse, rat for OVOS2
    Customized transgenic rodents for:
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     Browse compounds at ApexBio
     Search Addgene for plasmids for OVOS2
      Search eBioscience for proteins for OVOS2
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      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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