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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

OVOS2 Gene

protein-coding GIFtS: 29
GCID: GC12M031267

OVOS2

Search for OVOS2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ovostatin 2²
Ovostatin Homolog 2²

External Ids:	Entrez Gene: 144203²	UniProtKB: Q6IE36³

Export aliases for OVOS2 gene to outside databases

Previous GC identifers: GC12M031156 GC12M031157 GC12M031163 GC12M031265

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: OVOS2_HUMAN, Q6IE36

Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NT_009714.17 NC_018923.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OVOS2 gene promoter:
TBP LHX3b/Lhx3b Pbx1a Brachyury POU3F1 HNF-1A CREB HNF-1 LHX3a/Lhx3a RSRFC4
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OVOS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.21

OVOS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OVOS2 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M031267: view genomic region (about GC identifiers)

Start:	31,267,684 bp from pter	End:	31,359,088 bp from pter
Size:	91,405 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: OVOS2_HUMAN, Q6IE36 (See protein sequence)

Recommended Name: Ovostatin homolog 2 precursor

Size: 1432 amino acids; 161251 Da

Subunit: Homotetramer (By similarity)

Subcellular location: Secreted (By similarity)

Sequence caution: Sequence=CAE51409.1; Type=Erroneous gene model prediction;

Explore the universe of human proteins at neXtProt for OVOS2: NX_Q6IE36

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6IE36

OVOS2 Protein expression data from MOPED and PaxDb: About this image

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	IEA	--

OVOS2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OVOS2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR001599 Macroglobln_a2

IPR011626 A2M_comp

IPR002890 A2M_N

IPR011625 A2M_N_2

IPR009048 A-macroglobulin_rcpt-bd

Graphical View of Domain Structure for InterPro Entry Q6IE36

ProtoNet protein and cluster: Q6IE36

UniProtKB/Swiss-Prot: OVOS2_HUMAN, Q6IE36

Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: OVOS2_HUMAN, Q6IE36

Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism (By similarity)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004867	serine-type endopeptidase inhibitor activity	IEA	--

OVOS2 for ontologies About GeneDecksing

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OVOS2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for OVOS2 gene (2 alternative transcripts):

NM_001080502.1 NM_173498.1

Unigene Cluster for OVOS2:

Ovostatin 2

Hs.524331 [show with all ESTs]

Unigene Representative Sequence: CR749395

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Additional cDNA sequence:

AL831947.1 BC029816.1 BC039117.1 BC046190.1 CR749395.1

14 DOTS entries:

DT.100027310 DT.92468056 DT.101984145 DT.416416 DT.100027309 DT.40130872 DT.95114876 DT.92427039

DT.121149409 DT.121149415 DT.95191967 DT.121149408 DT.121149466 DT.97816159

24/63 AceView cDNA sequences (see all 63):

BU732570 AI963894 AW768250 BC039117 BN000357 X85621 X85617 AA665477

BM703967 BF437976 AA629594 BV204927 BV199370 T18947 AI004884 BF448350

BV204929 BV199369 BX955676 BU615950 BV204936 BF059235 BC046190 BF446506

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

OVOS2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACCATCTGA

About this image

OVOS2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Beating cell clusters (Spontaneous differen...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See OVOS2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for OVOS2

SOURCE GeneReport for Unigene cluster: Hs.524331

SABiosciences Custom PCR Arrays for OVOS2

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for OVOS2 gene from 1/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LOC396151¹	ovostatin	55.65(n) 45.01(a)		396151 NM_205226.1 NP_990557.1

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for OVOS2 gene

OVOS

9 SIMAP similar genes for OVOS2 using alignment to 2 protein entries: OVOS2_HUMAN (see all proteins):

DKFZp686C0338 OVOS1 A2M PZP A2ML1 C3

C4A C4B CPAMD8

OVOS2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs182991154^1,2	--	31266798(+)	`GCCTAC/GAGTTA`	1	--	ds500¹		0	--	--	--	--
rs151177113^1,2	--	31267023(+)	`AAACTA/TTGTAA`	1	--	ds500¹		0	--	--	--	--
rs141042321^1,2	--	31267049(+)	`ATAAAA/GTAATT`	1	--	ds500¹		0	--	--	--	--
rs2543314^1,2	--	31267443(+)	`TAGAAA/CAAATG`	1	--	ut3¹		0	--	--	--	--
rs149836604^1,2	--	31267504(+)	`TTTTAC/TGGAAC`	1	--	ut3¹		0	--	--	--	--
rs2543315^1,2	--	31267562(+)	`AAAAAC/TATATG`	1	--	ut3¹		0	--	--	--	--
rs145846329^1,2	--	31267610(+)	`ATGAAA/GTACAC`	1	--	ut3¹		0	--	--	--	--
rs141863442^1,2	--	31267676(+)	`TAGTTC/TTGTTT`	1	--	ut3¹		0	--	--	--	--
rs185731893^1,2	--	31267728(+)	`CTCTAC/TGTAGC`	2	I V	mis¹		0	--	--	--	--
rs190981761^1,2	--	31267733(+)	`TGTAGC/GTGTCT`	2	T S	mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for OVOS2 (31267684 - 31359088 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OVOS2: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OVOS2 for disorders About MalaCards

OVOS2 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: OVOS2 (1 document)

Export disorders for OVOS2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for OVOS2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with OVOS2)

Utopia: connect your pdf to the dynamic
world of online information

A genomic analysis of rat proteases and protease inhibitors. (PubMed id 15060002)^{1, 2} Puente X.S. and Lopez-Otin C. (2004)
Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PubMed id 20808825)¹ Chen X....Kong X. (2010)
The finished DNA sequence of human chromosome 12. (PubMed id 16541075)² Scherer S.E.... Gibbs R.A. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 144203

AceView: OVOS2

euGenes: HUgn144203

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for OVOS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for OVOS2 gene:
Search GeneIP for patents involving OVOS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section


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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes OVOS2 gene at Home site.

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OVOS2 Gene

OVOS2

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OVOS2 Gene

OVOS2

Aliasesfor OVOS2 gene

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Genome Databases showing OVOS2 gene

Other Databases showing OVOS2 gene

Specialized Databases showing OVOS2 gene

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Aliases
for OVOS2 gene

Summaries
for OVOS2 gene

Genomic Views
for OVOS2 gene

Proteins
for OVOS2 gene

Protein Domains /
Families
for OVOS2 gene

Function
for OVOS2 gene

Pathways & Interactions
for OVOS2 gene

Drugs & Compounds
for OVOS2 gene

Transcripts
for OVOS2 gene

Expression
for OVOS2 gene

Orthologs
for OVOS2 gene

Paralogs
for OVOS2 gene

Genomic Variants
for OVOS2 gene

Disorders / Diseases
for OVOS2 gene

Publications
for OVOS2 gene

Intellectual Property
for OVOS2 gene

Products
for OVOS2 gene