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Aliases for OVOS2 Gene

Aliases for OVOS2 Gene

  • Ovostatin 2 3

External Ids for OVOS2 Gene

Summaries for OVOS2 Gene

GeneCards Summary for OVOS2 Gene

OVOS2 (Ovostatin 2) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity.

UniProtKB/Swiss-Prot for OVOS2 Gene

  • Is able to inhibit all four classes of proteinases by a unique trapping mechanism.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVOS2 Gene

Genomics for OVOS2 Gene

Genomic Location for OVOS2 Gene

Start:
31,111,652 bp from pter
End:
31,206,154 bp from pter
Size:
94,503 bases
Orientation:
Minus strand

Genomic View for OVOS2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OVOS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVOS2 Gene

Regulatory Elements for OVOS2 Gene

Proteins for OVOS2 Gene

  • Protein details for OVOS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IE36-OVOS2_HUMAN
    Recommended name:
    Ovostatin homolog 2
    Protein Accession:
    Q6IE36
    Secondary Accessions:

    Protein attributes for OVOS2 Gene

    Size:
    1432 amino acids
    Molecular mass:
    161251 Da
    Quaternary structure:
    • Homotetramer.
    SequenceCaution:
    • Sequence=CAE51409.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OVOS2 Gene

Proteomics data for OVOS2 Gene at MOPED

Post-translational modifications for OVOS2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn35, Asn59, Asn159, Asn375, and Asn858

No data available for DME Specific Peptides for OVOS2 Gene

Domains for OVOS2 Gene

UniProtKB/Swiss-Prot:

OVOS2_HUMAN
Family:
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.:
    • Q6IE36
genes like me logo Genes that share domains with OVOS2: view

No data available for Gene Families for OVOS2 Gene

Function for OVOS2 Gene

Molecular function for OVOS2 Gene

UniProtKB/Swiss-Prot Function: Is able to inhibit all four classes of proteinases by a unique trapping mechanism.

Gene Ontology (GO) - Molecular Function for OVOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with OVOS2: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OVOS2 Gene

Localization for OVOS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVOS2 Gene

Secreted.

Gene Ontology (GO) - Cellular Components for OVOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with OVOS2: view

Pathways for OVOS2 Gene

SuperPathways for OVOS2 Gene

No Data Available

Interacting Proteins for OVOS2 Gene

Gene Ontology (GO) - Biological Process for OVOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with OVOS2: view

No data available for Pathways by source for OVOS2 Gene

Transcripts for OVOS2 Gene

Unigene Clusters for OVOS2 Gene

Ovostatin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OVOS2 Gene

No ASD Table

Relevant External Links for OVOS2 Gene

GeneLoc Exon Structure for
OVOS2

Expression for OVOS2 Gene

mRNA expression in normal human tissues for OVOS2 Gene

mRNA expression in normal human tissues for OVOS2 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for OVOS2 Gene

SOURCE GeneReport for Unigene cluster for OVOS2 Gene Hs.524331

genes like me logo Genes that share expressions with OVOS2: view

Orthologs for OVOS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OVOS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OVOS2 36
  • 81.51 (n)
  • 73.85 (a)
dog
(Canis familiaris)
Mammalia LOC611455 36
  • 83.21 (n)
  • 77.53 (a)
mouse
(Mus musculus)
Mammalia BC048546 36
  • 72.32 (n)
  • 64.11 (a)
rat
(Rattus norvegicus)
Mammalia RGD1565709 36
  • 71.63 (n)
  • 62.53 (a)
chicken
(Gallus gallus)
Aves OVST 36
  • 55.39 (n)
  • 44.39 (a)
Species with no ortholog for OVOS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OVOS2 Gene

ENSEMBL:
Gene Tree for OVOS2 (if available)
TreeFam:
Gene Tree for OVOS2 (if available)

Paralogs for OVOS2 Gene

Selected SIMAP similar genes for OVOS2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OVOS2: view

No data available for Paralogs for OVOS2 Gene

Variants for OVOS2 Gene

Sequence variations from dbSNP and Humsavar for OVOS2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs25559 -- 31,116,255(-) GTAAT(-/ATGAT)GAGTT intron-variant
rs255533 -- 31,119,870(-) CGATG(G/T)GGGTC intron-variant
rs255534 -- 31,119,818(-) GCCTC(G/T)CGGGG intron-variant
rs255535 -- 31,119,789(-) GATGG(G/T)GGTCC intron-variant
rs255536 -- 31,119,764(-) GGAAG(A/T)GGGGC intron-variant

Relevant External Links for OVOS2 Gene

HapMap Linkage Disequilibrium report
OVOS2
Human Gene Mutation Database (HGMD)
OVOS2

No data available for Structural Variations from Database of Genomic Variants (DGV) for OVOS2 Gene

Disorders for OVOS2 Gene

Relevant External Links for OVOS2

Genetic Association Database (GAD)
OVOS2
Human Genome Epidemiology (HuGE) Navigator
OVOS2
genes like me logo Genes that share disorders with OVOS2: view

No data available for UniProtKB/Swiss-Prot for OVOS2 Gene

Publications for OVOS2 Gene

  1. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente X.S. … Lopez-Otin C. (Genome Res. 2004) 3 4
  2. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PMID: 20808825) Chen X. … Kong X. (PLoS ONE 2010) 3 49
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OVOS2 Gene

Sources for OVOS2 Gene

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