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Aliases for OVOS2 Gene

Aliases for OVOS2 Gene

  • Ovostatin 2 3

External Ids for OVOS2 Gene

Previous GeneCards Identifiers for OVOS2 Gene

  • GC12M031156
  • GC12M031157
  • GC12M031163
  • GC12M031265
  • GC12M031267

Summaries for OVOS2 Gene

GeneCards Summary for OVOS2 Gene

OVOS2 (Ovostatin 2) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is ENSG00000214776.

UniProtKB/Swiss-Prot for OVOS2 Gene

  • Is able to inhibit all four classes of proteinases by a unique trapping mechanism.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVOS2 Gene

Genomics for OVOS2 Gene

Regulatory Elements for OVOS2 Gene

Enhancers for OVOS2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G031228 0.7 ENCODE 0.7 +2.9 2917 1.4 TFAP4 NFIA TAF1 ZNF133 MAX ZNF48 RAD21 YY1 JUND HNF4G DDX11 OVOS2 LOC101060058
GH12G031234 0.7 ENCODE 0.7 -2.4 -2385 1.7 CTCF ZBTB21 FEZF1 RAD21 POLR2A ZNF366 SCRT2 ZSCAN29 ZBTB20 SCRT1 DDX11 FAM60A DDX11-AS1 OVOS2 ENSG00000270766
GH12G031205 1.2 Ensembl ENCODE dbSUPER 0.3 +26.6 26558 1.7 ZBTB11 TRIM22 ZNF140 ZNF426 ZNF394 RBBP5 ZNF781 ZNF518A RELA ZNF664 DDX11 BICD1 IPO8 LINC00941 OVOS2 LOC101060058
GH12G031238 0.7 ENCODE 0.4 -6.5 -6470 0.2 CTCF ZNF654 TRIM22 ZNF2 RAD21 RFX5 ZNF121 SMC3 ZNF143 KDM1A FAM60A DDX11 DDX11-AS1 OVOS2 ENSG00000270766
GH12G031200 0.9 dbSUPER 0.3 +31.1 31133 2.7 ELF3 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZSCAN9 RARA SLC30A9 CREM DDX11 OVOS2 LOC101060058
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OVOS2 on UCSC Golden Path with GeneCards custom track

Genomic Location for OVOS2 Gene

31,111,652 bp from pter
31,232,532 bp from pter
120,881 bases
Minus strand

Genomic View for OVOS2 Gene

Genes around OVOS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OVOS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OVOS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVOS2 Gene

Proteins for OVOS2 Gene

  • Protein details for OVOS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ovostatin homolog 2
    Protein Accession:

    Protein attributes for OVOS2 Gene

    1432 amino acids
    Molecular mass:
    161251 Da
    Quaternary structure:
    • Homotetramer.
    • Sequence=CAE51409.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OVOS2 Gene

Post-translational modifications for OVOS2 Gene

  • Glycosylation at isoforms=35, isoforms=59, isoforms=159, isoforms=375, and posLast=858858
  • Modification sites at PhosphoSitePlus

Other Protein References for OVOS2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OVOS2 Gene

Domains & Families for OVOS2 Gene

Suggested Antigen Peptide Sequences for OVOS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
genes like me logo Genes that share domains with OVOS2: view

No data available for Gene Families for OVOS2 Gene

Function for OVOS2 Gene

Molecular function for OVOS2 Gene

UniProtKB/Swiss-Prot Function:
Is able to inhibit all four classes of proteinases by a unique trapping mechanism.

Gene Ontology (GO) - Molecular Function for OVOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004867 serine-type endopeptidase inhibitor activity IEA --
genes like me logo Genes that share ontologies with OVOS2: view
genes like me logo Genes that share phenotypes with OVOS2: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OVOS2 Gene

Localization for OVOS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVOS2 Gene


Gene Ontology (GO) - Cellular Components for OVOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with OVOS2: view

No data available for Subcellular locations from COMPARTMENTS for OVOS2 Gene

Pathways & Interactions for OVOS2 Gene

SuperPathways for OVOS2 Gene

No Data Available

Interacting Proteins for OVOS2 Gene

Gene Ontology (GO) - Biological Process for OVOS2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010951 negative regulation of endopeptidase activity IEA --
genes like me logo Genes that share ontologies with OVOS2: view

No data available for Pathways by source and SIGNOR curated interactions for OVOS2 Gene

Drugs & Compounds for OVOS2 Gene

No Compound Related Data Available

Transcripts for OVOS2 Gene

Unigene Clusters for OVOS2 Gene

Ovostatin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OVOS2 Gene

No ASD Table

Relevant External Links for OVOS2 Gene

GeneLoc Exon Structure for

Expression for OVOS2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OVOS2 Gene

mRNA expression in normal human tissues for OVOS2 Gene

Protein differential expression in normal tissues from HIPED for OVOS2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OVOS2 Gene

Protein tissue co-expression partners for OVOS2 Gene

SOURCE GeneReport for Unigene cluster for OVOS2 Gene:

genes like me logo Genes that share expression patterns with OVOS2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OVOS2 Gene

Orthologs for OVOS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OVOS2 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC611455 34
  • 83.21 (n)
(Bos Taurus)
Mammalia OVOS2 34
  • 81.51 (n)
(Mus musculus)
Mammalia BC048546 34
  • 72.32 (n)
A2ml1 16
(Rattus norvegicus)
Mammalia RGD1565709 34
  • 71.63 (n)
(Gallus gallus)
Aves OVST 34
  • 55.39 (n)
Species where no ortholog for OVOS2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OVOS2 Gene

Gene Tree for OVOS2 (if available)
Gene Tree for OVOS2 (if available)

Paralogs for OVOS2 Gene

Paralogs for OVOS2 Gene

(10) SIMAP similar genes for OVOS2 Gene using alignment to 2 proteins: Pseudogenes for OVOS2 Gene

genes like me logo Genes that share paralogs with OVOS2: view

Variants for OVOS2 Gene

Sequence variations from dbSNP and Humsavar for OVOS2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000069237 -- 31,114,390(+) GCTAA(A/G)CTTAC downstream-variant-500B
rs1000090130 -- 31,114,030(+) TATCA(A/C)AACAT downstream-variant-500B
rs1000090755 -- 31,164,961(+) CAACC(G/T)GTACC intron-variant
rs1000122518 -- 31,177,073(+) AATTG(C/T)TAATA intron-variant
rs1000168646 -- 31,173,640(+) ATAAA(C/T)GAATG intron-variant

Relevant External Links for OVOS2 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OVOS2 Gene

Disorders for OVOS2 Gene

Relevant External Links for OVOS2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for OVOS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OVOS2 Gene

Publications for OVOS2 Gene

  1. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PMID: 20808825) Chen X. … Kong X. (PLoS ONE 2010) 3 46 64
  2. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente X.S. … Lopez-Otin C. (Genome Res. 2004) 3 4 64
  3. Expression analysis of ovostatin 2 reveals its involvement in proliferation, invasion and angiogenesis of cutaneous malignant melanoma. (PMID: 24112097) Huang Y.X. … Sun J.F. (J. Dermatol. 2013) 3 64
  4. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 4 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for OVOS2 Gene

Sources for OVOS2 Gene

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