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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OVOS2 Gene

protein-coding   GIFtS: 30
GCID: GC12M031267

Ovostatin 2


  Search for OVOS2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ovostatin 22
Ovostatin Homolog 22

External Ids:    Entrez Gene: 1442032   UniProtKB: Q6IE363   

Export aliases for OVOS2 gene to outside databases

Previous GC identifers: GC12M031156 GC12M031157 GC12M031163 GC12M031265


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OVOS2 Gene: 
OVOS2 is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is OVOS.

UniProtKB/Swiss-Prot: OVOS2_HUMAN, Q6IE36
Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NT_009714.17  NC_018923.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OVOS2 gene promoter:
         TBP   LHX3b/Lhx3b   Pbx1a   Brachyury   POU3F1   HNF-1A   CREB   HNF-1   LHX3a/Lhx3a   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for OVOS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OVOS2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p11.21   

OVOS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OVOS2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M031267:  view genomic region     (about GC identifiers)

Start:
31,267,684 bp from pter      End:
31,359,088 bp from pter
Size:
91,405 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OVOS2_HUMAN, Q6IE36 (See protein sequence)
Recommended Name: Ovostatin homolog 2 precursor  
Size: 1432 amino acids; 161251 Da
Subunit: Homotetramer (By similarity)
Subcellular location: Secreted (By similarity)
Sequence caution: Sequence=CAE51409.1; Type=Erroneous gene model prediction;

Explore the universe of human proteins at neXtProt for OVOS2: NX_Q6IE36

Explore proteomics data for OVOS2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6IE36

  • OVOS2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OVOS2 Protein Expression

    Human Recombinant Protein Products for OVOS2: 
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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IEA--

    OVOS2 for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/7 InterPro protein domains (see all 7):
     IPR001599 Macroglobln_a2
     IPR011626 A2M_comp
     IPR002890 A2M_N
     IPR011625 A2M_N_2
     IPR009048 A-macroglobulin_rcpt-bd

    Graphical View of Domain Structure for InterPro Entry Q6IE36

    ProtoNet protein and cluster: Q6IE36

    UniProtKB/Swiss-Prot: OVOS2_HUMAN, Q6IE36
    Similarity: Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family


    OVOS2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OVOS2_HUMAN, Q6IE36
    Function: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004867serine-type endopeptidase inhibitor activity IEA--
         
    OVOS2 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OVOS2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OVOS2

    Search CenterWatch for drugs/clinical trials and news about OVOS2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for OVOS2 gene (2 alternative transcripts): 
    NM_001080502.1  NM_173498.1  

    Unigene Cluster for OVOS2:

    Ovostatin 2
    Hs.524331  [show with all ESTs]
    Unigene Representative Sequence: CR749395
    miRNA
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    Additional mRNA sequence: 

    AL831947.1 BC029816.1 BC039117.1 BC046190.1 CR749395.1 

    14 DOTS entries:

    DT.100027310  DT.92468056  DT.101984145  DT.416416  DT.100027309  DT.40130872  DT.95114876  DT.92427039 
    DT.121149409  DT.121149415  DT.95191967  DT.121149408  DT.121149466  DT.97816159 

    24/63 AceView cDNA sequences (see all 63):

    AW768250 AI963894 BN000357 BC039117 AA665477 X85621 X85617 BU732570 
    BV204927 AA629594 CD677926 BF437976 AW090713 BF433019 BV204936 BX955676 
    T18947 AI004884 BU615950 BV199369 BC046190 AI914285 BV204929 BF059235 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OVOS2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACCATCTGA
    OVOS2 Expression
    About this image


    See OVOS2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OVOS2

    SOURCE GeneReport for Unigene cluster: Hs.524331
        SABiosciences Custom PCR Arrays for OVOS2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OVOS2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for OVOS2 gene from 2/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia BC0485461 cDNA sequence BC048546 70.61(n)
    62.25(a)
      232400  NM_001001179.3  NP_001001179.2 
    chicken
    (Gallus gallus)
    Aves LOC3961511 ovostatin 55.65(n)
    45.01(a)
      396151  NM_205226.1  NP_990557.1 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OVOS2 gene
    OVOS  
    10 SIMAP similar genes for OVOS2 using alignment to 2 protein entries:     OVOS2_HUMAN (see all proteins):
    DKFZp686C0338    OVOS1    A2M    PZP    A2ML1    C3
    C4A    C4B    C4B_2    CPAMD8

    OVOS2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2782 SNPs in OVOS2 are shown (see all 2782)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23028541,2
    F--31134538(+) CCTTTT/CACAAA 1 -- ds50011Minor allele frequency- C:0.07EA 742
    rs2021297521,2
    C--31134538(+) CCTTTC/TACAAA 1 -- ds50010--------
    rs25433141,2
    --31134753(+) TAGAAA/CAAATG 1 -- ds50010--------
    rs1498366041,2
    --31134814(+) TTTTAC/TGGAAC 1 -- ds50010--------
    rs25433151,2
    --31134872(+) AAAAAC/TATATG 1 -- ds50010--------
    rs1458463291,2
    --31134920(+) ATGAAA/GTACAC 1 -- ds50010--------
    rs1418634421,2
    C--31134986(+) TAGTTC/TTGTTT 1 -- ds50010--------
    rs1857318931,2
    C--31135038(+) CTCTAC/TGTAGC 2 I V mis10--------
    rs1909817611,2
    --31135043(+) TGTAGC/GTGTCT 2 T S mis10--------
    rs1140609441,2
    F--31135297(+) GAAGAG/TAAAAT 1 -- int11Minor allele frequency- T:0.02WA 118

    HapMap Linkage Disequilibrium report for OVOS2 (31267684 - 31359088 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OVOS2: --
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OVOS2 for disorders           About MalaCards

    OVOS2 for disorders           About GeneDecksing

    Genetic Association Database (GAD): OVOS2
    Human Genome Epidemiology (HuGE) Navigator: OVOS2 (1 document)

    Export disorders for OVOS2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OVOS2 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OVOS2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PubMed id 20808825)1, 4 Chen X....Kong X. (2010)
    2. A genomic analysis of rat proteases and protease inhibitors. (PubMed id 15060002)1, 2 Puente X.S. and Lopez-Otin C. (2004)
    3. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 144203 AceView: OVOS2 euGenes: HUgn144203

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OVOS2 gene:
    Search GeneIP for patents involving OVOS2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Browse Proteins at Cloud-Clone Corp.
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     Search LifeMap BioReagents cell lines for OVOS2
     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OVOS2
     Browse SwitchGear 3'UTR luciferase reporter plasmids for OVOS2
     Browse SwitchGear Promoter luciferase reporter plasmids for OVOS2
     Search ThermoFisher Antibodies for OVOS2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OVOS2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for OVOS2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OVOS2
    Customized:
     lentivirus for stable overexpression of OVOS2
     lentivirus expression plasmids for stable overexpression of OVOS2
     adenovirus for overexpression of OVOS2
     LSBio Antibodies in human, mouse, rat for OVOS2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
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     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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