Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OVOS2 Gene

Aliases for OVOS2 Gene

  • Ovostatin 2 3

External Ids for OVOS2 Gene

Previous GeneCards Identifiers for OVOS2 Gene

  • GC12M031156
  • GC12M031157
  • GC12M031163
  • GC12M031265
  • GC12M031267

Summaries for OVOS2 Gene

GeneCards Summary for OVOS2 Gene

OVOS2 (Ovostatin 2) is a Protein Coding gene. GO annotations related to this gene include serine-type endopeptidase inhibitor activity. An important paralog of this gene is CD109.

UniProtKB/Swiss-Prot for OVOS2 Gene

  • Is able to inhibit all four classes of proteinases by a unique trapping mechanism.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVOS2 Gene

Genomics for OVOS2 Gene

Regulatory Elements for OVOS2 Gene

Genomic Location for OVOS2 Gene

Chromosome:
12
Start:
31,111,652 bp from pter
End:
31,232,532 bp from pter
Size:
120,881 bases
Orientation:
Minus strand

Genomic View for OVOS2 Gene

Genes around OVOS2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OVOS2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OVOS2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVOS2 Gene

Proteins for OVOS2 Gene

  • Protein details for OVOS2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6IE36-OVOS2_HUMAN
    Recommended name:
    Ovostatin homolog 2
    Protein Accession:
    Q6IE36

    Protein attributes for OVOS2 Gene

    Size:
    1432 amino acids
    Molecular mass:
    161251 Da
    Quaternary structure:
    • Homotetramer.
    SequenceCaution:
    • Sequence=CAE51409.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OVOS2 Gene

Proteomics data for OVOS2 Gene at MOPED

Post-translational modifications for OVOS2 Gene

  • Glycosylation at Asn 35, Asn 59, Asn 159, Asn 375, and Asn 858
  • Modification sites at PhosphoSitePlus

Other Protein References for OVOS2 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for OVOS2 Gene

Domains & Families for OVOS2 Gene

Suggested Antigen Peptide Sequences for OVOS2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6IE36

UniProtKB/Swiss-Prot:

OVOS2_HUMAN :
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
Family:
  • Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
genes like me logo Genes that share domains with OVOS2: view

No data available for Gene Families for OVOS2 Gene

Function for OVOS2 Gene

Molecular function for OVOS2 Gene

UniProtKB/Swiss-Prot Function:
Is able to inhibit all four classes of proteinases by a unique trapping mechanism.
genes like me logo Genes that share phenotypes with OVOS2: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OVOS2 Gene

Localization for OVOS2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVOS2 Gene

Secreted.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for OVOS2 Gene

Pathways & Interactions for OVOS2 Gene

SuperPathways for OVOS2 Gene

No Data Available

Interacting Proteins for OVOS2 Gene

Gene Ontology (GO) - Biological Process for OVOS2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for OVOS2 Gene

Drugs & Compounds for OVOS2 Gene

No Compound Related Data Available

Transcripts for OVOS2 Gene

Unigene Clusters for OVOS2 Gene

Ovostatin 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for OVOS2 Gene

No ASD Table

Relevant External Links for OVOS2 Gene

GeneLoc Exon Structure for
OVOS2

Expression for OVOS2 Gene

mRNA expression in normal human tissues for OVOS2 Gene

mRNA expression in normal human tissues for OVOS2 Gene

Protein differential expression in normal tissues from HIPED for OVOS2 Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for OVOS2 Gene



SOURCE GeneReport for Unigene cluster for OVOS2 Gene Hs.524331

genes like me logo Genes that share expression patterns with OVOS2: view

Protein tissue co-expression partners for OVOS2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for OVOS2 Gene

Orthologs for OVOS2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for OVOS2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia OVOS2 35
  • 81.51 (n)
  • 73.85 (a)
dog
(Canis familiaris)
Mammalia LOC611455 35
  • 83.21 (n)
  • 77.53 (a)
mouse
(Mus musculus)
Mammalia BC048546 35
  • 72.32 (n)
  • 64.11 (a)
BC048546 16
rat
(Rattus norvegicus)
Mammalia RGD1565709 35
  • 71.63 (n)
  • 62.53 (a)
chicken
(Gallus gallus)
Aves OVST 35
  • 55.39 (n)
  • 44.39 (a)
Species with no ortholog for OVOS2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for OVOS2 Gene

ENSEMBL:
Gene Tree for OVOS2 (if available)
TreeFam:
Gene Tree for OVOS2 (if available)

Paralogs for OVOS2 Gene

Paralogs for OVOS2 Gene

(10) SIMAP similar genes for OVOS2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with OVOS2: view

Variants for OVOS2 Gene

Sequence variations from dbSNP and Humsavar for OVOS2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs7971718 - 31,158,049(+) TGACC(A/G)TAACT nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs12309295 - 31,144,937(+) TTTCA(C/G)TAGAA nc-transcript-variant, reference, missense
rs11051266 - 31,136,021(+) CAACC(A/G)AAAAG nc-transcript-variant, reference, missense
rs17418189 - 31,116,381(-) GACTG(C/T)TTTTG nc-transcript-variant, reference, missense
rs25559 -- 31,116,255(-) GTAAT(-/AT/ATGAT)GAGTT intron-variant

Relevant External Links for OVOS2 Gene

HapMap Linkage Disequilibrium report
OVOS2
Human Gene Mutation Database (HGMD)
OVOS2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Variation tolerance for OVOS2 Gene

Disorders for OVOS2 Gene

Relevant External Links for OVOS2

Genetic Association Database (GAD)
OVOS2
Human Genome Epidemiology (HuGE) Navigator
OVOS2

No disorders were found for OVOS2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OVOS2 Gene

Publications for OVOS2 Gene

  1. Novel association strategy with copy number variation for identifying new risk Loci of human diseases. (PMID: 20808825) Chen X. … Kong X. (PLoS ONE 2010) 3 48 67
  2. Expression analysis of ovostatin 2 reveals its involvement in proliferation, invasion and angiogenesis of cutaneous malignant melanoma. (PMID: 24112097) Huang Y.X. … Sun J.F. (J. Dermatol. 2013) 3
  3. A genomic analysis of rat proteases and protease inhibitors. (PMID: 15060002) Puente X.S. … Lopez-Otin C. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for OVOS2 Gene

Sources for OVOS2 Gene

Back to Top

Content