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Aliases for OVOL3 Gene

Aliases for OVOL3 Gene

  • Ovo Like Zinc Finger 3 2 3 5
  • Putative Transcription Factor Ovo-Like Protein 3 3
  • Ovo-Like 3 (Drosophila) 2
  • OVO Homolog-Like 3 3
  • Ovo-Like 3 3
  • HOVO3 3

External Ids for OVOL3 Gene

Previous GeneCards Identifiers for OVOL3 Gene

  • GC19P037241
  • GC19P037050
  • GC19P041278
  • GC19U900376
  • GC19P036603
  • GC19P036111
  • GC19P036118

Summaries for OVOL3 Gene

GeneCards Summary for OVOL3 Gene

OVOL3 (Ovo Like Zinc Finger 3) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is OVOL2.

UniProtKB/Swiss-Prot for OVOL3 Gene

  • May act as a transcription regulator.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVOL3 Gene

Genomics for OVOL3 Gene

Regulatory Elements for OVOL3 Gene

Enhancers for OVOL3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G036041 1.1 Ensembl ENCODE 11.2 -66.9 -66932 1.8 ARID4B FEZF1 ZEB1 SCRT2 RCOR1 EGR2 ZNF362 SP5 CEBPB ZEB2 ZNF345 ZNF567 ZNF850 TBCB THAP8 WDR62 OVOL3 POLR2I ZNF829 TMEM147-AS1
GH19G036159 0.7 ENCODE dbSUPER 12.1 +52.0 52019 1.9 ZNF362 NFE2 CAPNS1 POLR2I TBCB OVOL3 SDHAF1 ZNF565 GC19P036360 GC19M038244
GH19G036157 0.4 FANTOM5 12.1 +48.8 48750 0.2 ZNF600 POLR2I TBCB OVOL3 SDHAF1 ZNF565 GC19P036360 GC19M038244
GH19G036028 0.4 FANTOM5 10.8 -80.3 -80303 0.2 ZNF624 THAP8 CTBP2P7 ZNF829 ZNF565 WDR62 SDHAF1 LRFN3 OVOL3 POLR2I TBCB
GH19G036110 0.7 ENCODE 0.7 +2.3 2262 1.0 BCOR ZNF263 ZMYM3 ZIC2 ZNF560 ZFP69B JUND GLIS2 POLR2A SMARCA4 WDR62 OVOL3 TBCB GC19P036325
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OVOL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for OVOL3 Gene

Chromosome:
19
Start:
36,108,829 bp from pter
End:
36,113,720 bp from pter
Size:
4,892 bases
Orientation:
Plus strand

Genomic View for OVOL3 Gene

Genes around OVOL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OVOL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OVOL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVOL3 Gene

Proteins for OVOL3 Gene

  • Protein details for OVOL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00110-OVOL3_HUMAN
    Recommended name:
    Putative transcription factor ovo-like protein 3
    Protein Accession:
    O00110

    Protein attributes for OVOL3 Gene

    Size:
    214 amino acids
    Molecular mass:
    23826 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB51180.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for OVOL3 Gene

Post-translational modifications for OVOL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OVOL3 Gene

No data available for DME Specific Peptides for OVOL3 Gene

Domains & Families for OVOL3 Gene

Protein Domains for OVOL3 Gene

Graphical View of Domain Structure for InterPro Entry

O00110

UniProtKB/Swiss-Prot:

OVOL3_HUMAN :
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
genes like me logo Genes that share domains with OVOL3: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for OVOL3 Gene

Function for OVOL3 Gene

Molecular function for OVOL3 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcription regulator.

Gene Ontology (GO) - Molecular Function for OVOL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003676 nucleic acid binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OVOL3: view

Phenotypes for OVOL3 Gene

GenomeRNAi human phenotypes for OVOL3:
genes like me logo Genes that share phenotypes with OVOL3: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for OVOL3 Gene

Localization for OVOL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVOL3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OVOL3 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for OVOL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with OVOL3: view

Pathways & Interactions for OVOL3 Gene

SuperPathways for OVOL3 Gene

No Data Available

Interacting Proteins for OVOL3 Gene

Gene Ontology (GO) - Biological Process for OVOL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with OVOL3: view

No data available for Pathways by source and SIGNOR curated interactions for OVOL3 Gene

Drugs & Compounds for OVOL3 Gene

No Compound Related Data Available

Transcripts for OVOL3 Gene

mRNA/cDNA for OVOL3 Gene

(5) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for OVOL3 Gene

Ovo-like 3 (Drosophila):
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for OVOL3 Gene

No ASD Table

Relevant External Links for OVOL3 Gene

GeneLoc Exon Structure for
OVOL3
ECgene alternative splicing isoforms for
OVOL3

Expression for OVOL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OVOL3 Gene

mRNA differential expression in normal tissues according to GTEx for OVOL3 Gene

This gene is overexpressed in Testis (x19.9).

NURSA nuclear receptor signaling pathways regulating expression of OVOL3 Gene:

OVOL3

SOURCE GeneReport for Unigene cluster for OVOL3 Gene:

Hs.143920
genes like me logo Genes that share expression patterns with OVOL3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for OVOL3 Gene

Orthologs for OVOL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for OVOL3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OVOL3 34 35
  • 99.84 (n)
cow
(Bos Taurus)
Mammalia OVOL3 34 35
  • 84.66 (n)
dog
(Canis familiaris)
Mammalia OVOL3 34 35
  • 84.19 (n)
mouse
(Mus musculus)
Mammalia Ovol3 34 16
  • 83.78 (n)
rat
(Rattus norvegicus)
Mammalia LOC100912425 34
  • 82.8 (n)
oppossum
(Monodelphis domestica)
Mammalia OVOL3 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101730693 34
  • 57.83 (n)
zebrafish
(Danio rerio)
Actinopterygii OVOL3 35
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ovo 35
  • 7 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-48 35
  • 27 (a)
OneToMany
Species where no ortholog for OVOL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OVOL3 Gene

ENSEMBL:
Gene Tree for OVOL3 (if available)
TreeFam:
Gene Tree for OVOL3 (if available)

Paralogs for OVOL3 Gene

Variants for OVOL3 Gene

Sequence variations from dbSNP and Humsavar for OVOL3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1001002920 -- 36,110,273(+) CAAGA(C/T)TAGCC intron-variant, upstream-variant-2KB
rs1001321717 -- 36,110,557(+) CTAGG(A/C/G)GCTAG intron-variant, upstream-variant-2KB
rs1001398030 -- 36,110,183(+) GACCC(C/G)CTTTG intron-variant, upstream-variant-2KB
rs1003249044 -- 36,112,913(+) GTGGC(A/G)AGGGC reference, missense
rs1003470 -- 36,111,827(+) gcaag(C/G)cactg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OVOL3 Gene

Variant ID Type Subtype PubMed ID
nsv833815 CNV loss 17160897

Variation tolerance for OVOL3 Gene

Gene Damage Index Score: 3.60; 56.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OVOL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OVOL3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OVOL3 Gene

Disorders for OVOL3 Gene

Relevant External Links for OVOL3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OVOL3

No disorders were found for OVOL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OVOL3 Gene

Publications for OVOL3 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 3 4 64
  2. Molecular phylogeny of OVOL genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions. (PMID: 22737237) Kumar A. … Grapputo A. (PLoS ONE 2012) 3 64
  3. Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice. (PMID: 12213202) Li B. … Dai X. (Genomics 2002) 3 64

Products for OVOL3 Gene

Sources for OVOL3 Gene

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