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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

OVOL3 Gene

protein-coding   GIFtS: 28
GCID: GC19P036603

Ovo-Like 3 (Drosophila)

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ovo-Like 3 (Drosophila)1 2
OVO Homolog-Like 32
Putative Transcription Factor Ovo-Like Protein 32

External Ids:    HGNC: 141861   Entrez Gene: 7283612   Ensembl: ENSG000001052617   UniProtKB: O001103   

Export aliases for OVOL3 gene to outside databases

Previous GC identifers: GC19P037241 GC19P037050 GC19P041278 GC19U900376


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for OVOL3 Gene: 
OVOL3 (ovo-like 3 (Drosophila)) is a protein-coding gene. Diseases associated with OVOL3 include blindness. GO annotations related to this gene include zinc ion binding and nucleic acid binding. An important paralog of this gene is GFI1.

UniProtKB/Swiss-Prot: OVOL3_HUMAN, O00110
Function: May act as a transcription regulator (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for OVOL3
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat OVOL3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

OVOL3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OVOL3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P036603:  view genomic region     (about GC identifiers)

Start:
36,602,104 bp from pter      End:
36,604,613 bp from pter
Size:
2,510 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: OVOL3_HUMAN, O00110 (See protein sequence)
Recommended Name: Putative transcription factor ovo-like protein 3  
Size: 214 amino acids; 23826 Da
Subcellular location: Nucleus (Potential)
Caution: Could be the product of a pseudogene
Sequence caution: Sequence=AAB51180.1; Type=Erroneous gene model prediction;

Explore the universe of human proteins at neXtProt for OVOL3: NX_O00110

Explore proteomics data for OVOL3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00110

  • OVOL3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    OVOL3 Protein Expression
    REFSEQ proteins: NP_001257877.1  
    ENSEMBL proteins: 
     ENSP00000465620   ENSP00000464809   ENSP00000262637  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    OVOL3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry O00110

    ProtoNet protein and cluster: O00110

    UniProtKB/Swiss-Prot: OVOL3_HUMAN, O00110
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers


    OVOL3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OVOL3_HUMAN, O00110
    Function: May act as a transcription regulator (By similarity)

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0008270zinc ion binding ----
    GO:0046872metal ion binding IEA--
         
    OVOL3 for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OVOL3

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--

    OVOL3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about OVOL3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for OVOL3 gene: 
    NM_001270948.1  

    Unigene Cluster for OVOL3:

    Ovo-like 3 (Drosophila)
    Hs.143920  [show with all ESTs]
    Unigene Representative Sequence: NM_001270948
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585332 ENST00000586670 ENST00000262637
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    1 DOTS entry:

    DT.75107026 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    OVOL3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    OVOL3 Expression
    About this image


    See OVOL3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for OVOL3

    SOURCE GeneReport for Unigene cluster: Hs.143920
        SABiosciences Custom PCR Arrays for OVOL3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OVOL3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for OVOL3 gene from 4/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ovol35 OVO homolog-like 3 (Drosophila)   --   7 (17.34 cM) 30233439 
    zebrafish
    (Danio rerio)
    Actinopterygii OVOL36
    ovo-like 3 (Drosophila)
    41(a)
    1 ↔ 1
    10(48282-54537)
    fruit fly
    (Drosophila melanogaster)
    Insecta ovo6
    ovo
    6(a)
    1 → many
    X(4942330-4964962)
    worm
    (Caenorhabditis elegans)
    Secernentea lin-486
    Protein LIN-48
    26(a)
    1 → many
    III(3745461-3747348)


    ENSEMBL Gene Tree for OVOL3 (if available)
    TreeFam Gene Tree for OVOL3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for OVOL3 gene
    GFI12  OVOL22  GFI1B2  FEZF12  FEZF22  OVOL12  
    18/86 SIMAP similar genes for OVOL3 using alignment to 4 protein entries:     OVOL3_HUMAN (see all proteins) (see all similar genes):
    ZNF569    SALL2    ZNF341    ZNF783    OVOL2    OVOL1
    ZNF653    ZNF683    SALL3    ZNF285    ZNF285A    ZNF775
    SALL1    ZBTB47    ZNF55    HZF16    ZNF652    CTCFL

    OVOL3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/94 SNPs in OVOL3 are shown (see all 94)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1861578741,2
    --36600147(+) GCTTAC/TCCAGG 1 -- us2k10--------
    rs1906818771,2
    --36600191(+) GCCTGA/TTCGGG 1 -- us2k10--------
    rs1513165671,2
    --36600307(+) TTACGC/TGATCA 1 -- us2k10--------
    rs1166879621,2
    C,F--36600308(+) TACGCG/AATCAT 1 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1143738101,2
    C,F--36600356(+) AGTTGC/ACAGGC 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1827526021,2
    --36600361(+) CCAGGA/CGCAAT 1 -- us2k10--------
    rs1169901011,2
    F--36600362(+) CAGGCG/ACAATG 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs1124500901,2
    F--36600371(+) TGGCTC/TACGCC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1865008171,2
    --36600374(+) CTCACG/TCCTGT 1 -- us2k10--------
    rs1503899051,2
    --36600506(+) TGGTGC/TGCACC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for OVOL3 (36602104 - 36604613 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for OVOL3: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for OVOL3:    About MalaCards
    blindness    


    OVOL3 for disorders           About GeneDecksing


    Export disorders for OVOL3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for OVOL3 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with OVOL3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    2. Molecular phylogeny of OVOL genes illustrates a conser ved C2H2 zinc finger domain coupled by hypervariable unstructured regions. (PubMed id 22737237)1 Kumar A....Grapputo A. (2012)
    3. Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice. (PubMed id 12213202)1 Li B.... Dai X. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 728361 HGNC: 14186 Ensembl:ENSG00000105261 euGenes: HUgn728361 ECgene: OVOL3
    H-InvDB: OVOL3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for OVOL3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for OVOL3 gene:
    Search GeneIP for patents involving OVOL3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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     See all of Abcam's Antibodies, Kits and Proteins for OVOL3
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     Browse Proteins at Cloud-Clone Corp.
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     Search LifeMap BioReagents cell lines for OVOL3
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for OVOL3
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     Search ThermoFisher Antibodies for OVOL3
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat OVOL3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for OVOL3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for OVOL3
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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