Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



OVOL2 Gene

protein-coding   GIFtS: 48
GCID: GC20M017937

Ovo-Like Zinc Finger 2

(Previous names: zinc finger protein 339, ovo-like 2 (Drosophila))
(Previous symbol: ZNF339)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ovo-Like Zinc Finger 21 2     Ovo-Like 2 (Drosophila)1
Zinc Finger Protein 3391 2 3     EUROIMAGE5665892
ZNF3391 2 3     Ovo-Like 22
hOvo22 3     Transcription Factor Ovo-Like 22

External Ids:    HGNC: 158041   Entrez Gene: 584952   Ensembl: ENSG000001258507   UniProtKB: Q9BRP03   
ORGUL members:         

Export aliases for OVOL2 gene to outside databases

Previous GC identifer: GC20M017947


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for OVOL2 Gene:
OVOL2 (ovo-like zinc finger 2) is a protein-coding gene. Diseases associated with OVOL2 include corneal edema, and blindness. GO annotations related to this gene include sequence-specific DNA binding RNA polymerase II transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is OVOL3.

UniProtKB/Swiss-Prot: OVOL2_HUMAN, Q9BRP0
Function: DNA-binding protein that binds to the 5'-G[GCT]GGGGG-3' core sequence. Probably acts as a transcription
regulator (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000020.11  NT_011387.9  NC_018931.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the OVOL2 gene promoter:
         MAZR   SREBP-1c   MyoD   Nkx2-5   CUTL1   SREBP-1b   PPAR-gamma1   SREBP-1a   PPAR-gamma2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidOVOL2 promoter sequence
   Search Chromatin IP Primers for OVOL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OVOL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p11.23   Ensembl cytogenetic band:  20p11.23   HGNC cytogenetic band: 20p11.23

OVOL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OVOL2 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M017937:  view genomic region     (about GC identifiers)

Start:
17,937,623 bp from pter      End:
18,039,832 bp from pter
Size:
102,210 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: OVOL2_HUMAN, Q9BRP0 (See protein sequence)
Recommended Name: Transcription factor Ovo-like 2  
Size: 275 amino acids; 30438 Da
Secondary accessions: Q5T8B4 Q9BX22 Q9HA54 Q9Y4M0
Alternative splicing: 2 isoforms:  Q9BRP0-1   Q9BRP0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for OVOL2: NX_Q9BRP0

Explore proteomics data for OVOL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See OVOL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_067043.2  
    ENSEMBL proteins: 
     ENSP00000278780  

    OVOL2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for OVOL2
    OriGene Custom MassSpec
    OriGene Custom Protein Services for OVOL2
    GenScript Custom Purified and Recombinant Proteins Services for OVOL2
    Novus Biologicals OVOL2 Protein
    Novus Biologicals OVOL2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for OVOL2

    OVOL2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for OVOL2
    OriGene Custom Antibody Services for OVOL2
    Novus Biologicals OVOL2 Antibodies
    Abcam antibodies for OVOL2
    Cloud-Clone Corp. Antibodies for OVOL2
    ThermoFisher Antibodies for OVOL2
    LSBio Antibodies in human, mouse, rat for OVOL2

    OVOL2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for OVOL2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OVOL2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for OVOL2
    Cloud-Clone Corp. CLIAs for OVOL2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ZNF: Zinc fingers, C2H2-type

    4 InterPro protein domains:
     IPR015880 Znf_C2H2-like
     IPR027775 C2H2_Znf_fam
     IPR013087 Znf_C2H2/integrase_DNA-bd
     IPR007087 Znf_C2H2

    Graphical View of Domain Structure for InterPro Entry Q9BRP0

    ProtoNet protein and cluster: Q9BRP0

    UniProtKB/Swiss-Prot: OVOL2_HUMAN, Q9BRP0
    Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family
    Similarity: Contains 4 C2H2-type zinc fingers


    OVOL2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OVOL2_HUMAN, Q9BRP0
    Function: DNA-binding protein that binds to the 5'-G[GCT]GGGGG-3' core sequence. Probably acts as a transcription
    regulator (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000981sequence-specific DNA binding RNA polymerase II transcription factor activity IBA--
    GO:0003677DNA binding IEA--
    GO:0044212transcription regulatory region DNA binding IDA19700410
    GO:0046872metal ion binding IEA--
         
    OVOL2 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for OVOL2:
     Decreased Wnt reporter activit  Increased gamma-H2AX phosphory 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ovol2):
     cardiovascular system  cellular  craniofacial  digestive/alimentary  embryogenesis 
     growth/size/body  hearing/vestibular/ear  mortality/aging  muscle  nervous system 
     vision/eye 

    OVOL2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ovol2tm1Sito for OVOL2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OVOL2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OVOL2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for OVOL2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for OVOL2

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat OVOL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OVOL2 (see all 18):
    hsa-miR-579 hsa-miR-30c hsa-miR-498 hsa-miR-3607-3p hsa-miR-767-5p hsa-miR-30d hsa-miR-1297 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidOVOL2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for OVOL2
    Predesigned siRNA for gene silencing in human, mouse, rat OVOL2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for OVOL2

    Clone
    Products:
         
    OriGene clones in human, mouse for OVOL2 (see all 5)
    OriGene ORF clones in mouse, rat for OVOL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OVOL2 (NM_021220)
    Sino Biological Human cDNA Clone for OVOL2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OVOL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OVOL2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for OVOL2
    Browse ESI BIO Cell Lines and PureStem Progenitors for OVOL2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OVOL2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    OVOL2_HUMAN, Q9BRP0: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IC19700410

    OVOL2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for OVOL2
    Interactions:

        Search GeneGlobe Interaction Network for OVOL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for OVOL2 (ENSP000002787804) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DHX9ENSP000003565204STRING: ENSP00000356520
    SNRPAENSP000002435634STRING: ENSP00000243563
    SNRPB2ENSP000002460714STRING: ENSP00000246071
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    JUPENSP000003111134STRING: ENSP00000311113
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis IEA--
    GO:0001755neural crest cell migration IEA--
    GO:0001842neural fold formation IEA--
    GO:0001947heart looping IEA--
    GO:0006357regulation of transcription from RNA polymerase II promoter IBA--

    OVOL2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for OVOL2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for OVOL2 gene: 
    NM_021220.2  

    Unigene Cluster for OVOL2:

    Ovo-like 2 (Drosophila)
    Hs.661013  [show with all ESTs]
    Unigene Representative Sequence: AK022284
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000486776 ENST00000278780(uc002wqi.1) ENST00000483661 ENST00000494030
    ENST00000462208
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat OVOL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate OVOL2 (see all 18):
    hsa-miR-579 hsa-miR-30c hsa-miR-498 hsa-miR-3607-3p hsa-miR-767-5p hsa-miR-30d hsa-miR-1297 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidOVOL2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for OVOL2
    Predesigned siRNA for gene silencing in human, mouse, rat OVOL2
    Clone
    Products:
         
    OriGene clones in human, mouse for OVOL2 (see all 5)
    OriGene ORF clones in mouse, rat for OVOL2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: OVOL2 (NM_021220)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for OVOL2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OVOL2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for OVOL2
    OriGene qSTAR qPCR primer pairs in human, mouse for OVOL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OVOL2
      QuantiTect SYBR Green Assays in human, mouse, rat OVOL2
      QuantiFast Probe-based Assays in human, mouse, rat OVOL2

    Additional mRNA sequence: AK022284.1 

    3 DOTS entries:

    DT.411255  DT.40115232  DT.99954540 

    Selected AceView cDNA sequences (see all 614):

    AI342525 NM_021220 AA922698 AI033642 AI192321 AA258179 F05788 BM742115 
    BM729163 CF134902 AW594587 AW517275 BU674231 AI149204 BX644167 CR601419 
    AI373642 N56795 CB054590 AA045820 CA416524 AI620931 AI281283 CA434837 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    OVOL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCCTGATGG
    OVOL2 Expression
    About this image

    OVOL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    OVOL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661013

    UniProtKB/Swiss-Prot: OVOL2_HUMAN, Q9BRP0
    Tissue specificity: Expressed in testis, ovary, heart and skeletal muscle

        Custom PCR Arrays for OVOL2
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for OVOL2
    OriGene qSTAR qPCR primer pairs in human, mouse for OVOL2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OVOL2
    QuantiTect SYBR Green Assays in human, mouse, rat OVOL2
    QuantiFast Probe-based Assays in human, mouse, rat OVOL2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OVOL2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for OVOL2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ovol21 , 5 ovo-like 2 (Drosophila)1, 5 85.04(n)1
    87.23(a)1
      2 (70.99 cM)5
    1075861  NM_026924.31  NP_081200.21 
     1443051755 
    chicken
    (Gallus gallus)
    Aves OVOL21 ovo-like 2 (Drosophila) 72.61(n)
    72.09(a)
      416720  XM_415018.4  XP_415018.3 
    lizard
    (Anolis carolinensis)
    Reptilia OVOL26
    ovo-like zinc finger 2
    65(a)
    1 ↔ 1
    4(74464495-74493903)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA981310.12   -- 78.65(n)    CA981310.1 
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-17e16.131 si:dkey-17e16.13 54.71(n)
    50.6(a)
      100534921  XM_003200839.2  XP_003200887.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ovo6
    ovo
    8(a)
    1 → many
    X(4942330-4964962)
    worm
    (Caenorhabditis elegans)
    Secernentea lin-486
    Protein LIN-48 (lin-48) mRNA, complete cds
    36(a)
    1 → many
    III(3745461-3747348) WBGene00003033


    ENSEMBL Gene Tree for OVOL2 (if available)
    TreeFam Gene Tree for OVOL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for OVOL2 gene
    OVOL32  OVOL12  
    6 SIMAP similar genes for OVOL2 using alignment to 1 protein entry:     OVOL2_HUMAN:
    OVOL1    OVOL3    ZNF78L1    ZNF808    PLZF    ZNF702P

    OVOL2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for OVOL2 (see all 853)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1415117211,2
    C--17953450(+) CCCAT-/AAAAAA 1 -- ds50010--------
    rs738993251,2
    C--17953555(+) TGGCCG/TTTTGT 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs38383811,2
    C--17953616(-) gagat-/Tggggt 1 -- ds50010--------
    rs1919430961,2
    --17953641(+) AAATTA/GGCTGG 1 -- ds50010--------
    rs37902941,2
    C,F,H--17953864(-) GTTATT/CGAGGT 1 -- ds5001 ese37Minor allele frequency- C:0.06EA NS 2282
    rs61362631,2
    C--17953914(+) CTGTAA/GGTCAA 1 -- ds5001 ese30--------
    rs1838078801,2
    --17954020(+) CTTAAA/CCAGCA 1 -- ut310--------
    rs1891701641,2
    --17954097(+) CTTCCA/GTGTGT 1 -- ut310--------
    rs72663201,2
    C,F--17954116(+) TTGGGG/CGAAAA 1 -- ut31 ese3 trp31Minor allele frequency- C:0.50WA 2
    rs32156391,2
    C--17954118(+) GGGGGA/-AAAAA 1 -- ut31 trp31Minor allele frequency- -:0.00NA 2

    HapMap Linkage Disequilibrium report for OVOL2 (17937623 - 18039832 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for OVOL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2660105CNV Deletion23128226
    nsv458945CNV Loss19166990
    nsv912809CNV Gain21882294
    nsv833933CNV Gain17160897
    nsv470543CNV Gain18288195
    nsv458944CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing OVOL2
    DNA2.0 Custom Variant and Variant Library Synthesis for OVOL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    2 diseases for OVOL2:    
    About MalaCards
    corneal edema    blindness

    1 disease from the University of Copenhagen DISEASES database for OVOL2:
    Corneal edema

    OVOL2 for disorders           About GeneDecksing


    Export disorders for OVOL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for OVOL2 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with OVOL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice. (PubMed id 12213202)1, 2 Li B.... Dai X. (Genomics 2002)
    4. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)
    5. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    6. Molecular phylogeny of OVOL genes illustrates a conserved C2H2 zinc finger domain coupled by hypervariable unstructured regions. (PubMed id 22737237)1 Kumar A....Grapputo A. (PLoS ONE 2012)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1. (PubMed id 19700410)1 Wells J....Dai X. (J. Biol. Chem. 2009)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 58495 HGNC: 15804 AceView: SNX5andZNF339 Ensembl:ENSG00000125850 euGenes: HUgn58495
    ECgene: OVOL2 H-InvDB: OVOL2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for OVOL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for OVOL2 gene:
    Search GeneIP for patents involving OVOL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for OVOL2   OriGene RNAi products in human, mouse, rat for OVOL2  
     OriGene qPCR primer pairs and template standards for OVOL2   OriGene Protein Over-expression Lysate for OVOL2  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for OVOL2  
     OriGene qSTAR qPCR primer pairs in human, mouse for OVOL2   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for OVOL2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for OVOL2   OriGene Custom Protein Services for OVOL2  

     
     
     Block miRNA regulation of human, mouse, rat OVOL2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing OVOL2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat OVOL2 Predesigned siRNA for gene silencing in human, mouse, rat OVOL2
     QuantiFast Probe-based Assays in human, mouse, rat OVOL2 QuantiTect SYBR Green Assays in human, mouse, rat OVOL2
     Custom PCR Arrays for OVOL2 Search Chromatin IP Primers for OVOL2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat OVOL2  Search GeneGlobe Interaction Network for OVOL2
     Regulatory tfbs in OVOL2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for OVOL2 GenScript cDNA clones with any tag delivered in your preferred vector for OVOL2
     GenScript Custom Assay Services for OVOL2 GenScript Custom overexpressing Cell Line Services for OVOL2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for OVOL2
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for OVOL2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     OVOL2 antibodies
     OVOL2 proteins
     OVOL2 lysates
     Antibodies for OVOL2
     See all of Abcam's Antibodies, Kits and Proteins for OVOL2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for OVOL2
     Antibodies for OVOL2
     ELISAs for OVOL2
     CLIAs for OVOL2



     Browse ESI BIO Cell Lines and PureStem Progenitors for OVOL2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for OVOL2
     SwitchGear 3'UTR luciferase reporter plasmids for OVOL2
     SwitchGear Promoter luciferase reporter plasmids for OVOL2
     ThermoFisher Antibodies for OVOL2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat OVOL2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for OVOL2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for OVOL2
     LSBio Antibodies in human, mouse, rat for OVOL2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      OVOL2 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4