Free for academic non-profit institutions. Other users need a Commercial license

Aliases for OVOL2 Gene

Aliases for OVOL2 Gene

  • Ovo-Like Zinc Finger 2 2 3
  • Zinc Finger Protein 339 2 3 4
  • ZNF339 3 4
  • Transcription Factor Ovo-Like 2 3
  • Ovo-Like 2 (Drosophila) 2
  • EUROIMAGE566589 3
  • HOvo2 4

External Ids for OVOL2 Gene

Previous HGNC Symbols for OVOL2 Gene

  • ZNF339

Previous GeneCards Identifiers for OVOL2 Gene

  • GC20M017947
  • GC20M017937

Summaries for OVOL2 Gene

GeneCards Summary for OVOL2 Gene

OVOL2 (Ovo-Like Zinc Finger 2) is a Protein Coding gene. Diseases associated with OVOL2 include corneal edema. GO annotations related to this gene include transcription regulatory region DNA binding and sequence-specific DNA binding RNA polymerase II transcription factor activity. An important paralog of this gene is OVOL1.

UniProtKB/Swiss-Prot for OVOL2 Gene

  • Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVOL2 Gene

Genomics for OVOL2 Gene

Regulatory Elements for OVOL2 Gene

Genomic Location for OVOL2 Gene

Start:
17,956,979 bp from pter
End:
18,059,190 bp from pter
Size:
102,212 bases
Orientation:
Minus strand

Genomic View for OVOL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OVOL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVOL2 Gene

Proteins for OVOL2 Gene

  • Protein details for OVOL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRP0-OVOL2_HUMAN
    Recommended name:
    Transcription factor Ovo-like 2
    Protein Accession:
    Q9BRP0
    Secondary Accessions:
    • Q5T8B4
    • Q9BX22
    • Q9HA54
    • Q9Y4M0

    Protein attributes for OVOL2 Gene

    Size:
    275 amino acids
    Molecular mass:
    30438 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for OVOL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for OVOL2 Gene

Proteomics data for OVOL2 Gene at MOPED

Post-translational modifications for OVOL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OVOL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for OVOL2 Gene

Domains for OVOL2 Gene

Gene Families for OVOL2 Gene

HGNC:
  • ZNF :Zinc fingers, C2H2-type

Protein Domains for OVOL2 Gene

Suggested Antigen Peptide Sequences for OVOL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BRP0

UniProtKB/Swiss-Prot:

OVOL2_HUMAN :
  • Q9BRP0
Family:
  • Belongs to the krueppel C2H2-type zinc-finger protein family.
Similarity:
  • Contains 4 C2H2-type zinc fingers.
genes like me logo Genes that share domains with OVOL2: view

Function for OVOL2 Gene

Molecular function for OVOL2 Gene

UniProtKB/Swiss-Prot Function: Zinc-finger transcription repressor factor. Plays a critical role to maintain the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition mainly through the up-regulation of ZEB1 expression. Positively regulates neuronal differentiation (By similarity). Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1.

Gene Ontology (GO) - Molecular Function for OVOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity IBA --
GO:0003677 DNA binding IEA --
GO:0044212 transcription regulatory region DNA binding IDA 19700410
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OVOL2: view
genes like me logo Genes that share phenotypes with OVOL2: view

Animal Models for OVOL2 Gene

MGI Knock Outs for OVOL2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for OVOL2 Gene

Localization for OVOL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVOL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OVOL2 Gene COMPARTMENTS Subcellular localization image for OVOL2 gene
Compartment Confidence
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for OVOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with OVOL2: view

Pathways for OVOL2 Gene

SuperPathways for OVOL2 Gene

No Data Available

Interacting Proteins for OVOL2 Gene

Gene Ontology (GO) - Biological Process for OVOL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001755 neural crest cell migration IEA --
GO:0001842 neural fold formation IEA --
GO:0001947 heart looping IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with OVOL2: view

No data available for Pathways by source for OVOL2 Gene

Transcripts for OVOL2 Gene

Unigene Clusters for OVOL2 Gene

Ovo-like 2 (Drosophila):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OVOL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OVOL2 Gene

No ASD Table

Relevant External Links for OVOL2 Gene

GeneLoc Exon Structure for
OVOL2
ECgene alternative splicing isoforms for
OVOL2

Expression for OVOL2 Gene

mRNA expression in normal human tissues for OVOL2 Gene

mRNA differential expression in normal tissues according to GTEx for OVOL2 Gene

This gene is overexpressed in Minor Salivary Gland (5.3), Skin - Sun Exposed (Lower leg) (4.4), and Stomach (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OVOL2 Gene

SOURCE GeneReport for Unigene cluster for OVOL2 Gene Hs.661013

mRNA Expression by UniProt/SwissProt for OVOL2 Gene

Q9BRP0-OVOL2_HUMAN
Tissue specificity: Expressed in testis, ovary, heart and skeletal muscle.
genes like me logo Genes that share expressions with OVOL2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for OVOL2 Gene

Orthologs for OVOL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for OVOL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OVOL2 35
  • 98.79 (n)
  • 98.91 (a)
OVOL2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OVOL2 35
  • 89.17 (n)
  • 89.78 (a)
OVOL2 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OVOL2 35
  • 90.35 (n)
  • 90.48 (a)
OVOL2 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ovol2 35
  • 85.04 (n)
  • 87.23 (a)
Ovol2 16
Ovol2 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OVOL2 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OVOL2 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ovol2 35
  • 85.48 (n)
  • 86.31 (a)
chicken
(Gallus gallus)
Aves OVOL2 35
  • 72.61 (n)
  • 72.09 (a)
OVOL2 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia OVOL2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ovol2 35
  • 66.05 (n)
  • 67.16 (a)
Str.4531 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-17e16.13 35
  • 54.71 (n)
  • 50.6 (a)
zgc:173486 36
  • 15 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta ovo 36
  • 8 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea lin-48 36
  • 36 (a)
OneToMany
Species with no ortholog for OVOL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OVOL2 Gene

ENSEMBL:
Gene Tree for OVOL2 (if available)
TreeFam:
Gene Tree for OVOL2 (if available)

Paralogs for OVOL2 Gene

Paralogs for OVOL2 Gene

Selected SIMAP similar genes for OVOL2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with OVOL2: view

Variants for OVOL2 Gene

Sequence variations from dbSNP and Humsavar for OVOL2 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs1976 -- 18,024,469(+) AACGG(C/T)AACTG utr-variant-3-prime
rs1122811 -- 18,044,710(-) CCTGG(A/G)CCTCT intron-variant
rs1122812 -- 18,044,568(-) TATCA(A/G)TGTTA intron-variant
rs1123497 -- 18,044,514(+) TCAGC(C/T)TCCTC intron-variant
rs1205252 -- 18,031,559(+) GTAAC(A/G)GAGCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OVOL2 Gene

Variant ID Type Subtype PubMed ID
nsv458944 CNV Gain 19166990
nsv470543 CNV Gain 18288195
nsv458945 CNV Loss 19166990
nsv833933 CNV Gain 17160897
esv2660105 CNV Deletion 23128226
nsv912809 CNV Gain 21882294

Relevant External Links for OVOL2 Gene

HapMap Linkage Disequilibrium report
OVOL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OVOL2 Gene

Disorders for OVOL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for OVOL2 Gene including...

Search for OVOL2 Gene in MalaCards »

(1) University of Copenhagen DISEASES for OVOL2 Gene

genes like me logo Genes that share disorders with OVOL2: view

No data available for UniProtKB/Swiss-Prot for OVOL2 Gene

Publications for OVOL2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Ovol2 suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing c-Myc and Notch1. (PMID: 19700410) Wells J. … Dai X. (J. Biol. Chem. 2009) 3 4
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 3 4
  5. Ovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice. (PMID: 12213202) Li B. … Dai X. (Genomics 2002) 3 4

Products for OVOL2 Gene

Sources for OVOL2 Gene

Back to Top

Content