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Aliases for OVOL1 Gene

Aliases for OVOL1 Gene

  • Ovo Like Transcriptional Repressor 1 2 3 5
  • Ovo-Like 1(Drosophila) 2 3
  • Ovo Like Zinc Finger 1 2 3
  • HOVO1 3 4
  • Putative Transcription Factor Ovo-Like 1 3
  • Ovo (Drosophila) Homolog-Like 1 2
  • Ovo Homolog-Like 1 3

External Ids for OVOL1 Gene

Previous GeneCards Identifiers for OVOL1 Gene

  • GC11P068095
  • GC11P067242
  • GC11P065804
  • GC11P065330
  • GC11P065329
  • GC11P065311
  • GC11P065555
  • GC11P061863

Summaries for OVOL1 Gene

Entrez Gene Summary for OVOL1 Gene

  • This gene encodes a putative zinc finger containing transcription factor that is highly similar to homologous protein in Drosophila and mouse. Based on known functions in these species, this protein is likely involved in hair formation and spermatogenesis in human as well. [provided by RefSeq, Aug 2011]

GeneCards Summary for OVOL1 Gene

OVOL1 (Ovo Like Transcriptional Repressor 1) is a Protein Coding gene. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is OVOL2.

UniProtKB/Swiss-Prot for OVOL1 Gene

  • Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).

Additional gene information for OVOL1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OVOL1 Gene

Genomics for OVOL1 Gene

Regulatory Elements for OVOL1 Gene

Enhancers for OVOL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H065791 1.4 Ensembl ENCODE dbSUPER 13 +5.6 5620 2.6 HDGF PKNOX1 SIN3A BMI1 BATF SCRT2 ZNF143 ATF7 RCOR1 ETV6 KRT8P26 EHBP1L1 OVOL1 EFEMP2 MRPL11 SIPA1 CTSW RNASEH2C OVOL1-AS1 PIR59464
GH11H065774 1.6 Ensembl ENCODE dbSUPER 8.9 -8.6 -8615 8.8 ARNT ARID4B SIN3A ZNF2 YY1 SLC30A9 CBX5 ZNF207 ZNF143 FOS RBM14 ENSG00000258297 LOC105369352 RBM4 SF1 SF3B2 ENSG00000254461 PCNX3 ZFPL1 RNASEH2C
GH11H065787 1.4 FANTOM5 ENCODE dbSUPER 9.7 +1.6 1611 4.4 GTF2F1 CTCF PKNOX1 FOXA2 SIN3A E2F1 CTBP1 GATA3 POLR2A ZNF26 CATSPER1 KRT8P26 MAP3K11 ZFPL1 ENSG00000258297 MEN1 SYVN1 LOC105369352 ENSG00000255038 RBM14
GH11H065819 1 ENCODE dbSUPER 11.9 +35.2 35207 5.4 ELF3 CTCF SAP130 MLX ZSCAN4 DMAP1 ZNF644 RARA YY1 NR2F6 CTSW MUS81 CFL1 OVOL1-AS1 OVOL1 AP5B1 ENSG00000255404 SART1 SNX32 EFEMP2
GH11H065811 0.8 Ensembl ENCODE 12.3 +25.2 25185 2 PKNOX1 ATF1 PRDM6 IKZF1 EBF1 CEBPG SNX32 CTSW MAP3K11 OVOL1-AS1 OVOL1 AP5B1 CFL1 PCNX3 CCDC85B FIBP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around OVOL1 on UCSC Golden Path with GeneCards custom track

Promoters for OVOL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040887 -122 201 SMARCE1 MAZ CTBP1 POLR2A TARDBP RCOR1 EZH2

Genomic Locations for OVOL1 Gene

Genomic Locations for OVOL1 Gene
chr11:65,787,022-65,797,219
(GRCh38/hg38)
Size:
10,198 bases
Orientation:
Plus strand
chr11:65,554,493-65,564,690
(GRCh37/hg19)

Genomic View for OVOL1 Gene

Genes around OVOL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
OVOL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for OVOL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OVOL1 Gene

Proteins for OVOL1 Gene

  • Protein details for OVOL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14753-OVOL1_HUMAN
    Recommended name:
    Putative transcription factor Ovo-like 1
    Protein Accession:
    O14753
    Secondary Accessions:
    • Q6PCB1

    Protein attributes for OVOL1 Gene

    Size:
    267 amino acids
    Molecular mass:
    30259 Da
    Quaternary structure:
    No Data Available

neXtProt entry for OVOL1 Gene

Post-translational modifications for OVOL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for OVOL1 Gene

No data available for DME Specific Peptides for OVOL1 Gene

Domains & Families for OVOL1 Gene

Gene Families for OVOL1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for OVOL1 Gene

Suggested Antigen Peptide Sequences for OVOL1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with OVOL1: view

No data available for UniProtKB/Swiss-Prot for OVOL1 Gene

Function for OVOL1 Gene

Molecular function for OVOL1 Gene

GENATLAS Biochemistry:
Drosophila OVO gene homolog,female germline-specific nuclear protein,expressed in placenta,fetal kidney,pancreas
UniProtKB/Swiss-Prot Function:
Putative transcription factor. Involved in hair formation and spermatogenesis. May function in the differentiation and/or maintenance of the urogenital system (By similarity).

Phenotypes From GWAS Catalog for OVOL1 Gene

Gene Ontology (GO) - Molecular Function for OVOL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with OVOL1: view
genes like me logo Genes that share phenotypes with OVOL1: view

Animal Models for OVOL1 Gene

MGI Knock Outs for OVOL1:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for OVOL1 Gene

Localization for OVOL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for OVOL1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for OVOL1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for OVOL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,IEA --
genes like me logo Genes that share ontologies with OVOL1: view

Pathways & Interactions for OVOL1 Gene

SuperPathways for OVOL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for OVOL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001822 kidney development IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with OVOL1: view

No data available for Pathways by source and SIGNOR curated interactions for OVOL1 Gene

Drugs & Compounds for OVOL1 Gene

No Compound Related Data Available

Transcripts for OVOL1 Gene

Unigene Clusters for OVOL1 Gene

Ovo-like 1(Drosophila):
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for OVOL1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b
SP1: - - - - -
SP2: - - - -
SP3: -
SP4:

Relevant External Links for OVOL1 Gene

GeneLoc Exon Structure for
OVOL1
ECgene alternative splicing isoforms for
OVOL1

Expression for OVOL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for OVOL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for OVOL1 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.8), Skin - Not Sun Exposed (Suprapubic) (x10.2), Skin - Sun Exposed (Lower leg) (x7.7), and Testis (x5.6).

NURSA nuclear receptor signaling pathways regulating expression of OVOL1 Gene:

OVOL1

SOURCE GeneReport for Unigene cluster for OVOL1 Gene:

Hs.134434

mRNA Expression by UniProt/SwissProt for OVOL1 Gene:

O14753-OVOL1_HUMAN
Tissue specificity: Expressed in fetal kidney, and also in adult pancreas and placenta. Not expressed in intestine, peripheral blood lymphocytes and ovary.

Evidence on tissue expression from TISSUES for OVOL1 Gene

  • Skin(2.3)
genes like me logo Genes that share expression patterns with OVOL1: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for OVOL1 Gene

Orthologs for OVOL1 Gene

This gene was present in the common ancestor of animals.

Orthologs for OVOL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OVOL1 33 34
  • 99.25 (n)
cow
(Bos Taurus)
Mammalia OVOL1 33 34
  • 91.51 (n)
mouse
(Mus musculus)
Mammalia Ovol1 33 16 34
  • 90.14 (n)
oppossum
(Monodelphis domestica)
Mammalia OVOL1 34
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OVOL1 33 34
  • 89.39 (n)
rat
(Rattus norvegicus)
Mammalia Ovol1 33
  • 89.39 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia OVOL1 34
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ovol1 33
  • 63.13 (n)
zebrafish
(Danio rerio)
Actinopterygii ovol1 33 34
  • 64.46 (n)
OVOL1 (2 of 2) 34
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ovo 35 34
  • 72 (a)
worm
(Caenorhabditis elegans)
Secernentea lin-48 34 35
  • 37 (a)
OneToMany
Species where no ortholog for OVOL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OVOL1 Gene

ENSEMBL:
Gene Tree for OVOL1 (if available)
TreeFam:
Gene Tree for OVOL1 (if available)

Paralogs for OVOL1 Gene

Paralogs for OVOL1 Gene

genes like me logo Genes that share paralogs with OVOL1: view

Variants for OVOL1 Gene

Sequence variations from dbSNP and Humsavar for OVOL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000481820 -- 65,793,117(+) GAAAA(A/T)TTTGC intron-variant
rs1000495589 -- 65,792,248(+) AGGCA(A/G)CCCAG intron-variant, upstream-variant-2KB
rs1000547189 -- 65,791,993(+) GGCAG(C/G)GTGGG intron-variant, upstream-variant-2KB
rs1000565625 -- 65,792,919(+) TCTCG(C/T)CGGCT intron-variant
rs1000762070 -- 65,796,733(+) GTGTA(A/T)AGAGG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for OVOL1 Gene

Variant ID Type Subtype PubMed ID
nsv1131027 CNV deletion 24896259
esv2759834 CNV gain 17122850

Variation tolerance for OVOL1 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for OVOL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
OVOL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OVOL1 Gene

Disorders for OVOL1 Gene

Relevant External Links for OVOL1

Genetic Association Database (GAD)
OVOL1
Human Genome Epidemiology (HuGE) Navigator
OVOL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
OVOL1

No disorders were found for OVOL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for OVOL1 Gene

Publications for OVOL1 Gene

  1. Characterization of a human homolog (OVOL1) of the Drosophila ovo gene, which maps to chromosome 11q13. (PMID: 9383297) Chidambaram A … Dean M (Mammalian genome : official journal of the International Mammalian Genome Society 1997) 2 3 4 60
  2. Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. (PMID: 22197932) Paternoster L … EArly Genetics & Lifecourse Epidemiology (EAGLE) Consortium (Nature genetics 2011) 3 45 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for OVOL1 Gene

Sources for OVOL1 Gene

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